                         SEQUENCE LISTING

<110>  Galapagos NV
       Fischer, David Frederik
       de Pril, Remko
       van Steenhoven, Desire Marie Petronella Catharina
       Janssen, Richard Antonius Jozef
       Kwak, Seung
       Howland, David S.
       Signer, Ethan
 
<120>  MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE 
       SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

<130>  GAL-P1079

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  4021
<212>  DNA
<213>  Homo Sapiens

<400>  1
tgtctggagc ttttctttcc tttattatta actaaagagc attctctacc attgcccagc       60

tgaaagcacc tagctcatag attctctgtg gggagagtga ataaagaatg ggggattgag      120

gcacagagtg ttaaaatagt gagacacagg attctaactg gcagactggc actttatctc      180

aattcttaac tgctgtgttg cctctcactt taaagacatc cacattccac cctgggcctt      240

gcccgtctgg tgagcccaat ctctgctggt cagtcacgca gttgaggtca gggaaggagt      300

aactcaagat gattttgatg ttgcagtttt aaatttcact ttgacttgag ctgggaaatc      360

ctttggccta ttataccatg gatgctaaaa atggttctaa ctgaaaaccc aaaccaagaa      420

atagcaacaa gtctagaatt cttactacta caaaactcac ctggatccct aagggcacag      480

caaagaatga gctattacgg cagcagctat catattatca atgcggacgc aaaataccca      540

ggctacccgc cagagcacat tatagctgag aagagaagag caagaagacg attacttcac      600

aaagatggca gctgtaatgt ctacttcaag cacatttttg gagaatgggg aagctatgtg      660

gttgacatct tcaccactct tgtggacacc aagtggcgcc atatgtttgt gatattttct      720

ttatcttata ttctctcgtg gttgatattt ggctctgtct tttggctcat agcctttcat      780

catggcgatc tattaaatga tccagacatc acaccttgtg ttgacaacgt ccattctttc      840

acaggggcct ttttgttctc cctagagacc caaaccacca taggatatgg ttatcgctgt      900

gttactgaag aatgttctgt ggccgtgctc atggtgatcc tccagtccat cttaagttgc      960

atcataaata cctttatcat tggagctgcc ttggccaaaa tggcaactgc tcgaaagaga     1020

gcccaaacca ttcgtttcag ctactttgca cttataggta tgagagatgg gaagctttgc     1080

ctcatgtggc gcattggtga ttttcggcca aaccacgtgg tagaaggaac agttagagcc     1140

caacttctcc gctatacaga agacagtgaa gggaggatga cgatggcatt taaagacctc     1200

aaattagtca acgaccaaat catcctggtc accccggtaa ctattgtcca tgaaattgac     1260

catgagagcc ctctgtatgc ccttgaccgc aaagcagtag ccaaagataa ctttgagatt     1320

ttggtgacat ttatctatac tggtgattcc actggaacat ctcaccaatc tagaagctcc     1380

tatgttcccc gagaaattct ctggggccat aggtttaatg atgtcttgga agttaagagg     1440

aagtattaca aagtgaactg cttacagttt gaaggaagtg tggaagtata tgcccccttt     1500

tgcagtgcca agcaattgga ctggaaagac cagcagctcc acatagaaaa agcaccacca     1560

gttcgagaat cctgcacgtc ggacaccaag gcgagacgaa ggtcatttag tgcagttgcc     1620

attgtcagca gctgtgaaaa ccctgaggag accaccactt ccgccacaca tgaatatagg     1680

gaaacacctt atcagaaagc tctcctgact ttaaacagaa tctctgtaga atcccaaatg     1740

tagtcctaaa ttgcaattat gagggctacc actgaatcat tttatctttc agccaatcaa     1800

gtcgttgtaa acgtggcttt tttgaaagtg ttatggctat gttttatgat gatgctgggt     1860

aagtagagta agttaaactt ggtaaaagat aatctaaaaa ttccatagtt ctcagttatt     1920

aaaatttttc ttgttcgcca attttgtatt aagaatgcta ttaagcctaa ttgattaaaa     1980

tttatctttt ttattatctt acatgcttgt atcttcagtt ggaggtgtag tattcaaaaa     2040

cggggaatga aggcaggaag gaggctggaa taaataaaaa taaaaataga caagtaagac     2100

agcataaata atacattttt aaacatgtca acattgataa tacaatgaag atttaccata     2160

aaaagtatca tatctaacca agatatgcaa aagatgcatt cagtaagctg taacgttgag     2220

aaatgtaact gtgaaatcag ctcaccagtt caagtcacta ggtttgccac ttggaccgtc     2280

ttggtttcag cgagcatagc gagtggctgt aagaaattgt ccatgccacc aattccactg     2340

ctacttgccc aggtagtgat cagtgagagt tagaagcaat tttttctcta accgatgagg     2400

cagaagaaaa gttaacagta tttaaagcag catttctctc ttaacgttcc tgggagactc     2460

caacaaatgg agaccagaaa caaggcaacc acgaccttgc taggttctct gaggagggga     2520

ctttctatgt tcacgtccca ccttcttcga ggacatgacc aagggacagg atcatacaga     2580

tgaggtgagg ggatggttag cagcgataaa cattctcaga cccttggaga gaaaccgttg     2640

ctagcttgct ggtcccgaaa gattgcaact ttggctgcta cagaaaggat agaacctttt     2700

tggggggagg gtggggaggg agatatttat ttgtgcccag aagcagttat gtatgcttct     2760

tgtcttggtt actgtacaag atacaaatga ctcgagttgt ggattgcaag aaactctttt     2820

attaaacttg gaacaaccat ttaaatgaag gattttgtga gatagaattc aattaaagcg     2880

atttgaatgc acagtaagtg gataatctga gtacaatgaa atttcttaag ttttagaaca     2940

tgagataaag ttgtatactc tactttcatg ttaaaatgtt aatcatgatt actttaagcc     3000

cacatccact gagtaaagag tcactttaaa ctttataaat caaagagata ttaggaacat     3060

tcagaattat ttgtgttttg tttttgtttt acattgttgc tgcactggca ataagtatgt     3120

ggcactgttt ttatttgttt atgttattta aatacacacc cagacacaca cacacacagt     3180

ttttgctttt tctggaaaat ctttctttct cttctctctc catgaaaatt aaaacacaca     3240

agtgaatgaa gtaattacat agtccaagat tagaaataca agtaaaatat ataggtatag     3300

gtagatagag tgcctttctg tttcttttct tttctttttt ctttttttgt tcttccttcc     3360

tttcttccct cctccccctc atccttccct ttctccttct tttccctttt tttttttttt     3420

ttgacctggg agtaataaag ttacttttta aatgcacgta tgcaatcttt tattcctctt     3480

gttttatgga taagagattt gttcaggtca aaagttgcaa aactgttctg aagcttaata     3540

ttagagaccc aagtaagatt gtttttagtc ttgcttgagg aatgcacact ccatttaaaa     3600

aattgtgcgc tctgtagatt tggattttac agcagcaatt acttggctaa attagagtac     3660

tgcaatcttg taagtagaaa acagccacca tgacaataaa caaaaacact taaaaatatt     3720

tttagcttgt tttacctaca tctagtttca tttcatcttg ctttgctttg ttgactctgc     3780

taccgctgat gtttgccttg tcaatatcag aataggggca tcagtgtccc gtgaaataca     3840

ttttgttgtg ctatgagcct ctgtaatcaa atgcttgtac tcagaagaga gtgtaaaatc     3900

agcatttcta tgtaacatat atctctaatt atctgtgtaa ttttataaca tactttgaca     3960

accccagtga gttacttaat aataaagatc ttaaaataat gcaaaaaaaa aaaaaaaaaa     4020

a                                                                     4021


<210>  2
<211>  3926
<212>  DNA
<213>  Homo Sapiens

<400>  2
tgtctggagc ttttctttcc tttattatta actaaagagc attctctacc attgcccagc       60

tgaaagcacc tagctcatag attctctgtg gggagagtga ataaagaatg ggggattgag      120

gcacagagtg ttaaaatagt gagacacagg attctaactg gcagactggc actttatctc      180

aattcttaac tgctgtgttg cctctcactt taaaggagta actcaagatg attttgatgt      240

tgcagtttta aatttcactt tgacttgagc tgggaaatcc tttggcctat tataccatgg      300

atgctaaaaa tggttctaac tgaaaaccca aaccaagaaa tagcaacaag tctagaattc      360

ttactactac aaaactcacc tggatcccta agggcacagc aaagaatgag ctattacggc      420

agcagctatc atattatcaa tgcggacgca aaatacccag gctacccgcc agagcacatt      480

atagctgaga agagaagagc aagaagacga ttacttcaca aagatggcag ctgtaatgtc      540

tacttcaagc acatttttgg agaatgggga agctatgtgg ttgacatctt caccactctt      600

gtggacacca agtggcgcca tatgtttgtg atattttctt tatcttatat tctctcgtgg      660

ttgatatttg gctctgtctt ttggctcata gcctttcatc atggcgatct attaaatgat      720

ccagacatca caccttgtgt tgacaacgtc cattctttca caggggcctt tttgttctcc      780

ctagagaccc aaaccaccat aggatatggt tatcgctgtg ttactgaaga atgttctgtg      840

gccgtgctca tggtgatcct ccagtccatc ttaagttgca tcataaatac ctttatcatt      900

ggagctgcct tggccaaaat ggcaactgct cgaaagagag cccaaaccat tcgtttcagc      960

tactttgcac ttataggtat gagagatggg aagctttgcc tcatgtggcg cattggtgat     1020

tttcggccaa accacgtggt agaaggaaca gttagagccc aacttctccg ctatacagaa     1080

gacagtgaag ggaggatgac gatggcattt aaagacctca aattagtcaa cgaccaaatc     1140

atcctggtca ccccggtaac tattgtccat gaaattgacc atgagagccc tctgtatgcc     1200

cttgaccgca aagcagtagc caaagataac tttgagattt tggtgacatt tatctatact     1260

ggtgattcca ctggaacatc tcaccaatct agaagctcct atgttccccg agaaattctc     1320

tggggccata ggtttaatga tgtcttggaa gttaagagga agtattacaa agtgaactgc     1380

ttacagtttg aaggaagtgt ggaagtatat gccccctttt gcagtgccaa gcaattggac     1440

tggaaagacc agcagctcca catagaaaaa gcaccaccag ttcgagaatc ctgcacgtcg     1500

gacaccaagg cgagacgaag gtcatttagt gcagttgcca ttgtcagcag ctgtgaaaac     1560

cctgaggaga ccaccacttc cgccacacat gaatataggg aaacacctta tcagaaagct     1620

ctcctgactt taaacagaat ctctgtagaa tcccaaatgt agtcctaaat tgcaattatg     1680

agggctacca ctgaatcatt ttatctttca gccaatcaag tcgttgtaaa cgtggctttt     1740

ttgaaagtgt tatggctatg ttttatgatg atgctgggta agtagagtaa gttaaacttg     1800

gtaaaagata atctaaaaat tccatagttc tcagttatta aaatttttct tgttcgccaa     1860

ttttgtatta agaatgctat taagcctaat tgattaaaat ttatcttttt tattatctta     1920

catgcttgta tcttcagttg gaggtgtagt attcaaaaac ggggaatgaa ggcaggaagg     1980

aggctggaat aaataaaaat aaaaatagac aagtaagaca gcataaataa tacattttta     2040

aacatgtcaa cattgataat acaatgaaga tttaccataa aaagtatcat atctaaccaa     2100

gatatgcaaa agatgcattc agtaagctgt aacgttgaga aatgtaactg tgaaatcagc     2160

tcaccagttc aagtcactag gtttgccact tggaccgtct tggtttcagc gagcatagcg     2220

agtggctgta agaaattgtc catgccacca attccactgc tacttgccca ggtagtgatc     2280

agtgagagtt agaagcaatt ttttctctaa ccgatgaggc agaagaaaag ttaacagtat     2340

ttaaagcagc atttctctct taacgttcct gggagactcc aacaaatgga gaccagaaac     2400

aaggcaacca cgaccttgct aggttctctg aggaggggac tttctatgtt cacgtcccac     2460

cttcttcgag gacatgacca agggacagga tcatacagat gaggtgaggg gatggttagc     2520

agcgataaac attctcagac ccttggagag aaaccgttgc tagcttgctg gtcccgaaag     2580

attgcaactt tggctgctac agaaaggata gaaccttttt ggggggaggg tggggaggga     2640

gatatttatt tgtgcccaga agcagttatg tatgcttctt gtcttggtta ctgtacaaga     2700

tacaaatgac tcgagttgtg gattgcaaga aactctttta ttaaacttgg aacaaccatt     2760

taaatgaagg attttgtgag atagaattca attaaagcga tttgaatgca cagtaagtgg     2820

ataatctgag tacaatgaaa tttcttaagt tttagaacat gagataaagt tgtatactct     2880

actttcatgt taaaatgtta atcatgatta ctttaagccc acatccactg agtaaagagt     2940

cactttaaac tttataaatc aaagagatat taggaacatt cagaattatt tgtgttttgt     3000

ttttgtttta cattgttgct gcactggcaa taagtatgtg gcactgtttt tatttgttta     3060

tgttatttaa atacacaccc agacacacac acacacagtt tttgcttttt ctggaaaatc     3120

tttctttctc ttctctctcc atgaaaatta aaacacacaa gtgaatgaag taattacata     3180

gtccaagatt agaaatacaa gtaaaatata taggtatagg tagatagagt gcctttctgt     3240

ttcttttctt ttcttttttc tttttttgtt cttccttcct ttcttccctc ctccccctca     3300

tccttccctt tctccttctt ttcccttttt tttttttttt tgacctggga gtaataaagt     3360

tactttttaa atgcacgtat gcaatctttt attcctcttg ttttatggat aagagatttg     3420

ttcaggtcaa aagttgcaaa actgttctga agcttaatat tagagaccca agtaagattg     3480

tttttagtct tgcttgagga atgcacactc catttaaaaa attgtgcgct ctgtagattt     3540

ggattttaca gcagcaatta cttggctaaa ttagagtact gcaatcttgt aagtagaaaa     3600

cagccaccat gacaataaac aaaaacactt aaaaatattt ttagcttgtt ttacctacat     3660

ctagtttcat ttcatcttgc tttgctttgt tgactctgct accgctgatg tttgccttgt     3720

caatatcaga ataggggcat cagtgtcccg tgaaatacat tttgttgtgc tatgagcctc     3780

tgtaatcaaa tgcttgtact cagaagagag tgtaaaatca gcatttctat gtaacatata     3840

tctctaatta tctgtgtaat tttataacat actttgacaa ccccagtgag ttacttaata     3900

ataaagatct taaaataatg caaaaa                                          3926


<210>  3
<211>  4025
<212>  DNA
<213>  Homo Sapiens

<400>  3
gagaactcag tggcctttgt ctgtggtgaa tgtatccgga aaggcaaaga agagagagat       60

tctcctgtgg ggtttctcat ctccatggcg gtaggtgctg acagcttcag aagggtacta      120

acagggccaa gagaaaaggg ccctgagatg ctcagctacg gtgctcttac aagatgaaaa      180

ggacatgggg ttcagatctg cacttcatca tctttcacta agacatccac attccaccct      240

gggccttgcc cgtctggtga gcccaatctc tgctggtcag tcacgcagtt gaggtcaggg      300

aaggagtaac tcaagatgat tttgatgttg cagttttaaa tttcactttg acttgagctg      360

ggaaatcctt tggcctatta taccatggat gctaaaaatg gttctaactg aaaacccaaa      420

ccaagaaata gcaacaagtc tagaattctt actactacaa aactcacctg gatccctaag      480

ggcacagcaa agaatgagct attacggcag cagctatcat attatcaatg cggacgcaaa      540

atacccaggc tacccgccag agcacattat agctgagaag agaagagcaa gaagacgatt      600

acttcacaaa gatggcagct gtaatgtcta cttcaagcac atttttggag aatggggaag      660

ctatgtggtt gacatcttca ccactcttgt ggacaccaag tggcgccata tgtttgtgat      720

attttcttta tcttatattc tctcgtggtt gatatttggc tctgtctttt ggctcatagc      780

ctttcatcat ggcgatctat taaatgatcc agacatcaca ccttgtgttg acaacgtcca      840

ttctttcaca ggggcctttt tgttctccct agagacccaa accaccatag gatatggtta      900

tcgctgtgtt actgaagaat gttctgtggc cgtgctcatg gtgatcctcc agtccatctt      960

aagttgcatc ataaatacct ttatcattgg agctgccttg gccaaaatgg caactgctcg     1020

aaagagagcc caaaccattc gtttcagcta ctttgcactt ataggtatga gagatgggaa     1080

gctttgcctc atgtggcgca ttggtgattt tcggccaaac cacgtggtag aaggaacagt     1140

tagagcccaa cttctccgct atacagaaga cagtgaaggg aggatgacga tggcatttaa     1200

agacctcaaa ttagtcaacg accaaatcat cctggtcacc ccggtaacta ttgtccatga     1260

aattgaccat gagagccctc tgtatgccct tgaccgcaaa gcagtagcca aagataactt     1320

tgagattttg gtgacattta tctatactgg tgattccact ggaacatctc accaatctag     1380

aagctcctat gttccccgag aaattctctg gggccatagg tttaatgatg tcttggaagt     1440

taagaggaag tattacaaag tgaactgctt acagtttgaa ggaagtgtgg aagtatatgc     1500

ccccttttgc agtgccaagc aattggactg gaaagaccag cagctccaca tagaaaaagc     1560

accaccagtt cgagaatcct gcacgtcgga caccaaggcg agacgaaggt catttagtgc     1620

agttgccatt gtcagcagct gtgaaaaccc tgaggagacc accacttccg ccacacatga     1680

atatagggaa acaccttatc agaaagctct cctgacttta aacagaatct ctgtagaatc     1740

ccaaatgtag tcctaaattg caattatgag ggctaccact gaatcatttt atctttcagc     1800

caatcaagtc gttgtaaacg tggctttttt gaaagtgtta tggctatgtt ttatgatgat     1860

gctgggtaag tagagtaagt taaacttggt aaaagataat ctaaaaattc catagttctc     1920

agttattaaa atttttcttg ttcgccaatt ttgtattaag aatgctatta agcctaattg     1980

attaaaattt atctttttta ttatcttaca tgcttgtatc ttcagttgga ggtgtagtat     2040

tcaaaaacgg ggaatgaagg caggaaggag gctggaataa ataaaaataa aaatagacaa     2100

gtaagacagc ataaataata catttttaaa catgtcaaca ttgataatac aatgaagatt     2160

taccataaaa agtatcatat ctaaccaaga tatgcaaaag atgcattcag taagctgtaa     2220

cgttgagaaa tgtaactgtg aaatcagctc accagttcaa gtcactaggt ttgccacttg     2280

gaccgtcttg gtttcagcga gcatagcgag tggctgtaag aaattgtcca tgccaccaat     2340

tccactgcta cttgcccagg tagtgatcag tgagagttag aagcaatttt ttctctaacc     2400

gatgaggcag aagaaaagtt aacagtattt aaagcagcat ttctctctta acgttcctgg     2460

gagactccaa caaatggaga ccagaaacaa ggcaaccacg accttgctag gttctctgag     2520

gaggggactt tctatgttca cgtcccacct tcttcgagga catgaccaag ggacaggatc     2580

atacagatga ggtgagggga tggttagcag cgataaacat tctcagaccc ttggagagaa     2640

accgttgcta gcttgctggt cccgaaagat tgcaactttg gctgctacag aaaggataga     2700

acctttttgg ggggagggtg gggagggaga tatttatttg tgcccagaag cagttatgta     2760

tgcttcttgt cttggttact gtacaagata caaatgactc gagttgtgga ttgcaagaaa     2820

ctcttttatt aaacttggaa caaccattta aatgaaggat tttgtgagat agaattcaat     2880

taaagcgatt tgaatgcaca gtaagtggat aatctgagta caatgaaatt tcttaagttt     2940

tagaacatga gataaagttg tatactctac tttcatgtta aaatgttaat catgattact     3000

ttaagcccac atccactgag taaagagtca ctttaaactt tataaatcaa agagatatta     3060

ggaacattca gaattatttg tgttttgttt ttgttttaca ttgttgctgc actggcaata     3120

agtatgtggc actgttttta tttgtttatg ttatttaaat acacacccag acacacacac     3180

acacagtttt tgctttttct ggaaaatctt tctttctctt ctctctccat gaaaattaaa     3240

acacacaagt gaatgaagta attacatagt ccaagattag aaatacaagt aaaatatata     3300

ggtataggta gatagagtgc ctttctgttt cttttctttt cttttttctt tttttgttct     3360

tccttccttt cttccctcct ccccctcatc cttccctttc tccttctttt cccttttttt     3420

tttttttttg acctgggagt aataaagtta ctttttaaat gcacgtatgc aatcttttat     3480

tcctcttgtt ttatggataa gagatttgtt caggtcaaaa gttgcaaaac tgttctgaag     3540

cttaatatta gagacccaag taagattgtt tttagtcttg cttgaggaat gcacactcca     3600

tttaaaaaat tgtgcgctct gtagatttgg attttacagc agcaattact tggctaaatt     3660

agagtactgc aatcttgtaa gtagaaaaca gccaccatga caataaacaa aaacacttaa     3720

aaatattttt agcttgtttt acctacatct agtttcattt catcttgctt tgctttgttg     3780

actctgctac cgctgatgtt tgccttgtca atatcagaat aggggcatca gtgtcccgtg     3840

aaatacattt tgttgtgcta tgagcctctg taatcaaatg cttgtactca gaagagagtg     3900

taaaatcagc atttctatgt aacatatatc tctaattatc tgtgtaattt tataacatac     3960

tttgacaacc ccagtgagtt acttaataat aaagatctta aaataatgca aaaaaaaaaa     4020

aaaaa                                                                 4025


<210>  4
<211>  4504
<212>  DNA
<213>  Homo Sapiens

<400>  4
ggggcggggc ggcgcggcgc ggagccgagc aggacggccg ccatcttgcg cgcagctgga       60

gtcggtgcct gaggttgcag ccgagagtgt gcgccagccc gcggcccagc cgaagctctt      120

tcccgccgcc tctccgcgcc tcgcccaggt tcagctccgc ctgaccctcc gcttggcacg      180

gtcccctgac cctcagtccg gcctggtccg gccttccagc cgccccgggg acgatgaacg      240

gaggataaat ggtgcccaag gcagacagcg gcgccttcct gctgctcttc ctgctcgtgc      300

tcactgtcac cgagccgctg cggccagagc tgcggtgcaa ccctgggcag tttgcgtgtc      360

gcagcggcac catccagtgc atccccctcc cctggcagtg tgacggctgg gcgacttgcg      420

aggatgagag cgacgaagcc aactgtccag aagtgaccgg ggaggtgcgt cctcatcatg      480

ggaaggaggc tgtggatccg cggcaggggc gggccagagg aggcgaccct tcgcacttcc      540

acgcggtgaa cgtggcgcag cccgttcgct tcagcagttt cctagggaag tgcccgacag      600

ggtggcacca ctacgaaggc acggccagct gctaccgggt ctacctgagc ggggagaact      660

actgggatgc cgcgcagacc tgccagcgcc tgaatggctc tctcgccacc ttctccactg      720

accaggagct gcgctttgtc ctggcccagg aatgggacca gcccgagcgg agctttggtt      780

ggaaggacca gcgcaagttg tgggttggct atcagtatgt tatcactggc cggaaccgct      840

ccttggaagg tcgctgggag gtggcattca aaggctcttc agaggtgttc ctgcccccag      900

accccatctt tgcctcggcc atgtctgaga acgacaacgt gttctgtgcc cagcttcagt      960

gcttccattt ccccaccctg cggcaccacg acctccacag ctggcacgcc gagagctgct     1020

acgagaagtc ttcatttctg tgtaaaagaa gtcaaacatg tgttgacatc aaggacaacg     1080

tggtggatga agggttctac ttcaccccta agggggacga cccatgcctg agctgcacct     1140

gccatggagg ggagcctgag atgtgtgtgg ctgctctctg tgagaggccc cagggctgcc     1200

aacagtaccg caaggacccc aaagagtgct gcaagttcat gtgtctggac ccagatggca     1260

acagtctgtt tgactccatg gccagcggga tgcgcctggt cgtcagctgc atctcctcct     1320

tcctcatcct gtcactgctg ctcttcatgg tccaccggct gcgccagcgg cgccgggagc     1380

gcatcgagtc cctgattgga gcaaacttgc accacttcaa cctcggccgc aggatccctg     1440

gctttgatta cggcccagac gggtttggca cgggcctcac gccgctgcat ctttctgacg     1500

acggagaggg tgggactttc catttccacg accctccacc tccctacacg gcatacaagt     1560

acccggacat cggccagccc gacgaccctc cgccgcccta cgaggcctcc atccacccgg     1620

acagtgtgtt ctatgaccct gcagacgatg atgcttttga gcctgtggag gtcagcctgc     1680

cagcccctgg ggatggtggg agtgaaggtg cattactccg gcgcctggag cagcctctgc     1740

ccactgcggg ggcctctctg gcagacctgg aagactctgc cgacagcagc agcgccctgc     1800

tcgtgccccc tgaccctgcc cagagcggga gcaccccagc tgcagaggca ctgccagggg     1860

gtggccgcca cagccgcagc tccctcaata ctgtggtgta gacggcctgg cctgtacccc     1920

aacggtctgg gagcacctgt ctgttgtaga aaacaccggt ccctggggag acttgaaagg     1980

cccctgtccc agcctggacg ccacgcactg ccgcacgtca ctggcgggct cgcgtgtgta     2040

catagagacc acagcccgcc ttctgccaaa agaagtgatg gcctgcaccg agcttccttg     2100

agggcttcag aaacatgcat agctttggat cactgtcttc tcctttataa atggcagaag     2160

agtgacaaaa ttcattcaga ccgcacatgt tagaggcagg gaatgaagaa ggtactgtgg     2220

gccatggcca cacctgatgc gtttttggtg ggcttacttg gtgcagtgtg ctgtccagag     2280

agacctgctg acccagtctg ggacaggcac agtgggagct gccacagtgc cccttgctgg     2340

ccgccctcag gagggggcct ctggaccgtc agtgtggcgt aggcagtggg tctgcttcag     2400

ggaggcagcc tcttgacttt gtcacaacgg ttgcactgaa gatggccccc acaagcccag     2460

ttgtgaatat caaggtgacc ctgcccctgg ctgggagctc ccctggggct ctggaacctg     2520

aagccctgag aaggagagct tggaaggagg ttgagctctt cactgtgtct ttccatctgg     2580

gctctgcagc ccagctctgt ggcaggaggc ctgaccccac cccatcagtc cctctcccag     2640

cattgctgtg catggctccc tcaggaagaa gctctggagt ggggccgagg ccccagatgc     2700

tctgctgggg tctggggact gagctgcctc ctgtctctcc actctggagc cctgggctct     2760

tgcctcctgt tgaattgccc ctgggcctgc ccccggcccc atttgtgcca taaagggttg     2820

cttcattgca ggaggggtgg ctgaaaccac catcctgggc tgcatctatc tccttaaagt     2880

ccactcctta catcaccgcc actactgcag ctcagtgccc agcggccgca tgcacacctc     2940

ccggcccctc ctcagcagcg caggggctgg gggcccttcc tggcaccctt ttgcctgacg     3000

gaccctgttg cctgctcctg ggcagtggtt ttgttgcctg acacagggcc tttaacattt     3060

ctgaggtttg gagattaagc gggttctgtg cgatttttag cacatccata tcttttctac     3120

gttgaatgtc tggatctttc ctttgtatgt ttgtgtctct gtgtgtgtat gtggccaagc     3180

gtctgcaggt gagggtggca catggaactt cacgggtcac tgggggccca ctcttccagg     3240

gtcatcgatg catcctgggc tgtgctgagg cagtgctgtc tcgctcagtc tttccagacc     3300

agcggggcag cacctgggag gcctgtctga agcatgcagt tctgtggtgc tgctcgggga     3360

tggactccat gcacagtcca cttcttgaca cattctcaca ctgtggctgg agacccattt     3420

tttccatccc atgtggaatg agaatcttga gttgcccaca gacagacttg acctttgtgc     3480

cagaactgtc cagagctgtg agttttgtta ctgaattgcc tgtccctgag cttggcctgc     3540

tggagcatga tgctggaggc tgtgtgcggg caggcttgtg ctccccttgg agaagggctg     3600

ctacttaaca aggaagtcct ggccacagga gtcccctact ggctgcagag gacgaagcag     3660

gaagcatgcc gtggatccca catgcactgg ggcagggcag ccaggttcca gagcagcagg     3720

catgtgcatt atgggtgcca ggtggccagt gagggcccga ggaccacgca gcagagtccc     3780

ccacgggcct gagcctgaga gctcagagga ttcctgccag gcctcagaac tgtgtgtgcg     3840

ggacagggtg gctggcacga gatgtgtggg actgggacgc ttcctttggg gaccagagga     3900

acattagggg ccggtcagac acgtaggggg cagtgaggaa acggggtaaa gtggaccatg     3960

caggctgcag agggtgggcc ttgggctggc cggggttgct gggtggcccc ttccccatgg     4020

gcctccacaa gcactcaggc cactggcacg ttgggccagg cagaaggtcc acatggcagg     4080

gctgcctgga acaccgctgc cactgtggct ccaggaggcc cttgggagca tgaggagagc     4140

tggactcgct catctgttct tgcaccacca tccagaatgc cccctttgca aggcctgctg     4200

cagtccccag tctgaccagc aagtcccggg gtcacccttg ctgaaccttg tgctccaggg     4260

gtcctcctcc tctaggacca gcttgccacg gtttctcaga gcccaggtgc cctctgacct     4320

gccatgcgga ggtgggattt gatactgtac attgtcttga tgcctgtttt tttatgtttt     4380

cattaagggt ttttagtttt tggttgggtt gacactaact tttcttaaga tgctgtgaga     4440

atcatttcat ccaaatgcca aataaacttg tgttccggaa gaggaaaaaa aaaaaaaaaa     4500

aaaa                                                                  4504


<210>  5
<211>  3778
<212>  DNA
<213>  Homo Sapiens

<400>  5
agcagcgggg gcggccccgg gactgagccg gcatccctga gcctggctcc cctccctgcg       60

accgccgtca cctccttctc cttccttttc cctccgccct ccgtgccctg aggaaaggcg      120

cgctcctccc cttcccctgg ggcgctccgc cggggcctcc tcccgggcct ccgttcccgc      180

cgcggccccg gttccggcgg gggcagcctc cgggttcggg gctccttctc ctggggacgc      240

tggggcttag cttgctccgc gcagaggcgg ccgccctccc ccaaagaaaa aactggctgc      300

ttctaagtgc gaagccggct gggcgggctg gtgccagaaa gggtgtgtct tcactgccct      360

aagatggcct ttaaggttgg acgtgataag tatgagcctg cagctgtttc agaacaaggt      420

gataaaaagg gcaaaaaggg caaaaaagac agggacatgg atgaactgaa gaaagaagtt      480

tctatggatg atcataaact tagccttgat gaacttcatc gtaaatatgg aacagacttg      540

agccggggat taacatctgc tcgtgcagct gagatcctgg cgcgagatgg tcccaacgcc      600

ctcactcccc ctcccactac tcctgaatgg atcaagtttt gtcggcagct ctttgggggg      660

ttctcaatgt tactgtggat tggagcgatt ctttgtttct tggcttatag catccaagct      720

gctacagaag aggaacctca aaacgataat ctgtacctgg gtgtggtgct atcagccgtt      780

gtaatcataa ctggttgctt ctcctactat caagaagcta aaagttcaaa gatcatggaa      840

tccttcaaaa acatggtccc tcagcaagcc cttgtgattc gaaatggtga gaaaatgagc      900

ataaatgcgg aggaagttgt ggttggggat ctggtggaag taaaaggagg agaccgaatt      960

cctgctgacc tcagaatcat atctgcaaat ggctgcaagg tggataactc ctcgctcact     1020

ggtgaatcag aaccccagac taggtctcca gatttcacaa atgaaaaccc cctggagacg     1080

aggaacattg ccttcttttc aaccaattgt gttgaaggca ccgcacgtgg tattgttgtc     1140

tacactgggg atcgcactgt gatgggaaga attgccacac ttgcttctgg gctggaagga     1200

ggccagaccc ccattgctgc agaaattgaa cattttatcc acatcatcac gggtgtggct     1260

gtgttcctgg gtgtgtcttt cttcatcctt tctctcatcc ttgagtacac ctggcttgag     1320

gctgtcatct tcctcatcgg tatcatcgta gccaatgtgc cggaaggttt gctggccact     1380

gtcacggtct gtctgacact tactgccaaa cgcatggcaa ggaaaaactg cttagtgaag     1440

aacttagaag ctgtggagac cttggggtcc acgtccacca tctgctctga taaaactgga     1500

actctgactc agaaccggat gacagtggcc cacatgtggt ttgacaatca aatccatgaa     1560

gctgatacga cagagaatca gagtggtgtc tcttttgaca agacttcagc tacctggctt     1620

gctctgtcca gaattgcagg tctttgtaac agggcagtgt ttcaggctaa ccaggaaaac     1680

ctacctattc ttaagcgggc agttgcagga gatgcctctg agtcagcact cttaaagtgc     1740

atagagctgt gctgtggttc cgtgaaggag atgagagaaa gatacgccaa aatcgtcgag     1800

atacccttca actccaccaa caagtaccag ttgtctattc ataagaaccc caacacatcg     1860

gagccccaac acctgttggt gatgaagggc gccccagaaa ggatcctaga ccgttgcagc     1920

tctatcctcc tccacggcaa ggagcagccc ctggatgagg agctgaaaga cgcctttcag     1980

aacgcctatt tggagctggg gggcctcgga gaacgagtcc taggtttctg ccacctcttt     2040

ctgccagatg aacagtttcc tgaagggttc cagtttgaca ctgacgatgt gaatttccct     2100

atcgataatc tgtgctttgt tgggctcatc tccatgattg accctccacg ggcggccgtt     2160

cctgatgccg tgggcaaatg tcgaagtgct ggaattaagg tcatcatggt cacaggagac     2220

catccaatca cagctaaagc tattgccaaa ggtgtgggca tcatctcaga aggcaatgag     2280

accgtggaag acattgctgc ccgcctcaac atcccagtca gccaggtgaa ccccagggat     2340

gccaaggcct gcgtagtaca cggcagtgat ctaaaggaca tgacctccga gcagctggat     2400

gacattttga agtaccacac tgagatagtg tttgccagga cctcccctca gcagaagctc     2460

atcattgtgg aaggctgcca aagacagggt gctatcgtgg ctgtgactgg tgacggtgtg     2520

aatgactctc cagctttgaa gaaagcagac attggggttg ctatggggat tgctggctca     2580

gatgtgtcca agcaagctgc tgacatgatt cttctggatg acaactttgc ctcaattgtg     2640

actggagtag aggaaggtcg tctgatcttt gataacttga agaaatccat tgcttatacc     2700

ttaaccagta acattcccga gatcaccccg ttcctgatat ttattattgc aaacattcca     2760

ctaccactgg ggactgtcac catcctctgc attgacttgg gcactgacat ggttcctgcc     2820

atctccctgg cttatgagca ggctgagagt gacatcatga agagacagcc cagaaatccc     2880

aaaacagaca aacttgtgaa tgagcggctg atcagcatgg cctatgggca gattggaatg     2940

atccaggccc tgggaggctt ctttacttac tttgtgattc tggctgagaa cggcttcctc     3000

ccaattcacc tgttgggcct ccgagtggac tgggatgacc gctggatcaa cgatgtggaa     3060

gacagctacg ggcagcagtg gacctatgag cagaggaaaa tcgtggagtt cacctgccac     3120

acagccttct tcgtcagtat cgtggtggtg cagtgggccg acttggtcat ctgtaagacc     3180

aggaggaatt cggtcttcca gcaggggatg aagaacaaga tcttgatatt tggcctcttt     3240

gaagagacag ccctggctgc tttcctttcc tactgccctg gaatgggtgt tgctcttagg     3300

atgtatcccc tcaaacctac ctggtggttc tgtgccttcc cctactctct tctcatcttc     3360

gtatatgacg aagtcagaaa actcatcatc aggcgacgcc ctggcggctg ggtggagaag     3420

gaaacctact attagccccc cgtcctgcac gccgtggagc atcaggccac acactctgca     3480

tccgacaccc accccctctt tgtgtacttc agtcttggag tttggaactc taccctggta     3540

ggaaagcacc gcagcatgtg gggaagcaag acgtcctgga atgaagcatg tagctctatg     3600

gggggagggg ggagggctgc ctgaaaacca tccatctgtg gaaatgacag cggggaaggt     3660

ttttatgtgc ctttttgttt ttgtaaaaaa ggaacacccg gaaagactga aagaatacat     3720

tttatatctg gatttttaca aataaagatg gctattataa tggaaaaaaa aaaaaaaa       3778


<210>  6
<211>  3778
<212>  DNA
<213>  Homo Sapiens

<400>  6
agcagcgggg gcggccccgg gactgagccg gcatccctga gcctggctcc cctccctgcg       60

accgccgtca cctccttctc cttccttttc cctccgccct ccgtgccctg aggaaaggcg      120

cgctcctccc cttcccctgg ggcgctccgc cggggcctcc tcccgggcct ccgttcccgc      180

cgcggccccg gttccggcgg gggcagcctc cgggttcggg gctccttctc ctggggacgc      240

tggggcttag cttgctccgc gcagaggcgg ccgccctccc ccaaagaaaa aactggctgc      300

ttctaagtgc gaagccggct gggcgggctg gtgccagaaa gggtgtgtct tcactgccct      360

aagatggcct ttaaggttgg acgtgataag tatgagcctg cagctgtttc agaacaaggt      420

gataaaaagg gcaaaaaggg caaaaaagac agggacatgg atgaactgaa gaaagaagtt      480

tctatggatg atcataaact tagccttgat gaacttcatc gtaaatatgg aacagacttg      540

agccggggat taacatctgc tcgtgcagct gagatcctgg cgcgagatgg tcccaacgcc      600

ctcactcccc ctcccactac tcctgaatgg atcaagtttt gtcggcagct ctttgggggg      660

ttctcaatgt tactgtggat tggagcgatt ctttgtttct tggcttatag catccaagct      720

gctacagaag aggaacctca aaacgataat ctgtacctgg gtgtggtgct atcagccgtt      780

gtaatcataa ctggttgctt ctcctactat caagaagcta aaagttcaaa gatcatggaa      840

tccttcaaaa acatggtccc tcagcaagcc cttgtgattc gaaatggtga gaaaatgagc      900

ataaatgcgg aggaagttgt ggttggggat ctggtggaag taaaaggagg agaccgaatt      960

cctgctgacc tcagaatcat atctgcaaat ggctgcaagg tggataactc ctcgctcact     1020

ggtgaatcag aaccccagac taggtctcca gatttcacaa atgaaaaccc cctggagacg     1080

aggaacattg ccttcttttc aaccaattgt gttgaaggca ccgcacgtgg tattgttgtc     1140

tacactgggg atcgcactgt gatgggaaga attgccacac ttgcttctgg gctggaagga     1200

ggccagaccc ccattgctgc agaaattgaa cattttatcc acatcatcac gggtgtggct     1260

gtgttcctgg gtgtgtcttt cttcatcctt tctctcatcc ttgagtacac ctggcttgag     1320

gctgtcatct tcctcatcgg tatcatcgta gccaatgtgc cggaaggttt gctggccact     1380

gtcacggtct gtctgacact tactgccaaa cgcatggcaa ggaaaaactg cttagtgaag     1440

aacttagaag ctgtggagac cttggggtcc acgtccacca tctgctctga taaaactgga     1500

actctgactc agaaccggat gacagtggcc cacatgtggt ttgacaatca aatccatgaa     1560

gctgatacga cagagaatca gagtggtgtc tcttttgaca agacttcagc tacctggctt     1620

gctctgtcca gaattgcagg tctttgtaac agggcagtgt ttcaggctaa ccaggaaaac     1680

ctacctattc ttaagcgggc agttgcagga gatgcctctg agtcagcact cttaaagtgc     1740

atagagctgt gctgtggttc cgtgaaggag atgagagaaa gatacgccaa aatcgtcgag     1800

atacccttca actccaccaa caagtaccag ttgtctattc ataagaaccc caacacatcg     1860

gagccccaac acctgttggt gatgaagggc gccccagaaa ggatcctaga ccgttgcagc     1920

tctatcctcc tccacggcaa ggagcagccc ctggatgagg agctgaaaga cgcctttcag     1980

aacgcctatt tggagctggg gggcctcgga gaacgagtcc taggtttctg ccacctcttt     2040

ctgccagatg aacagtttcc tgaagggttc cagtttgaca ctgacgatgt gaatttccct     2100

atcgataatc tgtgctttgt tgggctcatc tccatgattg accctccacg ggcggccgtt     2160

cctgatgccg tgggcaaatg tcgaagtgct ggaattaagg tcatcatggt cacaggagac     2220

catccaatca cagctaaagc tattgccaaa ggtgtgggca tcatctcaga aggcaatgag     2280

accgtggaag acattgctgc ccgcctcaac atcccagtca gccaggtgaa ccccagggat     2340

gccaaggcct gcgtagtaca cggcagtgat ctaaaggaca tgacctccga gcagctggat     2400

gacattttga agtaccacac tgagatagtg tttgccagga cctcccctca gcagaagctc     2460

atcattgtgg aaggctgcca aagacagggt gctatcgtgg ctgtgactgg tgacggtgtg     2520

aatgactctc cagctttgaa gaaagcagac attggggttg ctatggggat tgctggctca     2580

gatgtgtcca agcaagctgc tgacatgatt cttctggatg acaactttgc ctcaattgtg     2640

actggagtag aggaaggtcg tctgatcttt gataacttga agaaatccat tgcttatacc     2700

ttaaccagta acattcccga gatcaccccg ttcctgatat ttattattgc aaacattcca     2760

ctaccactgg ggactgtcac catcctctgc attgacttgg gcactgacat ggttcctgcc     2820

atctccctgg cttatgagca ggctgagagt gacatcatga agagacagcc cagaaatccc     2880

aaaacagaca aacttgtgaa tgagcggctg atcagcatgg cctatgggca gattggaatg     2940

atccaggccc tgggaggctt ctttacttac tttgtgattc tggctgagaa cggcttcctc     3000

ccaattcacc tgttgggcct ccgagtggac tgggatgacc gctggatcaa cgatgtggaa     3060

gacagctacg ggcagcagtg gacctatgag cagaggaaaa tcgtggagtt cacctgccac     3120

acagccttct tcgtcagtat cgtggtggtg cagtgggccg acttggtcat ctgtaagacc     3180

aggaggaatt cggtcttcca gcaggggatg aagaacaaga tcttgatatt tggcctcttt     3240

gaagagacag ccctggctgc tttcctttcc tactgccctg gaatgggtgt tgctcttagg     3300

atgtatcccc tcaaacctac ctggtggttc tgtgccttcc cctactctct tctcatcttc     3360

gtatatgacg aagtcagaaa actcatcatc aggcgacgcc ctggcggctg ggtggagaag     3420

gaaacctact attagccccc cgtcctgcac gccgtggagc atcaggccac acactctgca     3480

tccgacaccc accccctctt tgtgtacttc agtcttggag tttggaactc taccctggta     3540

ggaaagcacc gcagcatgtg gggaagcaag acgtcctgga atgaagcatg tagctctatg     3600

gggggagggg ggagggctgc ctgaaaacca tccatctgtg gaaatgacag cggggaaggt     3660

ttttatgtgc ctttttgttt ttgtaaaaaa ggaacacccg gaaagactga aagaatacat     3720

tttatatctg gatttttaca aataaagatg gctattataa tggaaaaaaa aaaaaaaa       3778


<210>  7
<211>  3754
<212>  DNA
<213>  Homo Sapiens

<400>  7
gacgtttcgc ggcgtgggcg gggccagcac gcaggttgca tattttagga agtgaggagg       60

aggcgcgggc tggagctgcg gcggggtctg gggcgcagag cagcggcggg aggaggcgga      120

cacgtggcaa cagcggtagc agcccgggcg gcggcagcaa cagcggcggc ggcatcggcc      180

cgagccgccg gccgccctcc caccctcccg ccccgcggca gccctagctc cctccacttg      240

gctcccctgg tcccgctcgc tcggccggga gctgctctgt gcttttctct ctgattctcc      300

agcgacagga cccggcgccg ggcactgagc accgccacca tggggaaggg ggttggacgt      360

gataagtatg agcctgcagc tgtttcagaa caaggtgata aaaagggcaa aaagggcaaa      420

aaagacaggg acatggatga actgaagaaa gaagtttcta tggatgatca taaacttagc      480

cttgatgaac ttcatcgtaa atatggaaca gacttgagcc ggggattaac atctgctcgt      540

gcagctgaga tcctggcgcg agatggtccc aacgccctca ctccccctcc cactactcct      600

gaatggatca agttttgtcg gcagctcttt ggggggttct caatgttact gtggattgga      660

gcgattcttt gtttcttggc ttatagcatc caagctgcta cagaagagga acctcaaaac      720

gataatctgt acctgggtgt ggtgctatca gccgttgtaa tcataactgg ttgcttctcc      780

tactatcaag aagctaaaag ttcaaagatc atggaatcct tcaaaaacat ggtccctcag      840

caagcccttg tgattcgaaa tggtgagaaa atgagcataa atgcggagga agttgtggtt      900

ggggatctgg tggaagtaaa aggaggagac cgaattcctg ctgacctcag aatcatatct      960

gcaaatggct gcaaggtgga taactcctcg ctcactggtg aatcagaacc ccagactagg     1020

tctccagatt tcacaaatga aaaccccctg gagacgagga acattgcctt cttttcaacc     1080

aattgtgttg aaggcaccgc acgtggtatt gttgtctaca ctggggatcg cactgtgatg     1140

ggaagaattg ccacacttgc ttctgggctg gaaggaggcc agacccccat tgctgcagaa     1200

attgaacatt ttatccacat catcacgggt gtggctgtgt tcctgggtgt gtctttcttc     1260

atcctttctc tcatccttga gtacacctgg cttgaggctg tcatcttcct catcggtatc     1320

atcgtagcca atgtgccgga aggtttgctg gccactgtca cggtctgtct gacacttact     1380

gccaaacgca tggcaaggaa aaactgctta gtgaagaact tagaagctgt ggagaccttg     1440

gggtccacgt ccaccatctg ctctgataaa actggaactc tgactcagaa ccggatgaca     1500

gtggcccaca tgtggtttga caatcaaatc catgaagctg atacgacaga gaatcagagt     1560

ggtgtctctt ttgacaagac ttcagctacc tggcttgctc tgtccagaat tgcaggtctt     1620

tgtaacaggg cagtgtttca ggctaaccag gaaaacctac ctattcttaa gcgggcagtt     1680

gcaggagatg cctctgagtc agcactctta aagtgcatag agctgtgctg tggttccgtg     1740

aaggagatga gagaaagata cgccaaaatc gtcgagatac ccttcaactc caccaacaag     1800

taccagttgt ctattcataa gaaccccaac acatcggagc cccaacacct gttggtgatg     1860

aagggcgccc cagaaaggat cctagaccgt tgcagctcta tcctcctcca cggcaaggag     1920

cagcccctgg atgaggagct gaaagacgcc tttcagaacg cctatttgga gctggggggc     1980

ctcggagaac gagtcctagg tttctgccac ctctttctgc cagatgaaca gtttcctgaa     2040

gggttccagt ttgacactga cgatgtgaat ttccctatcg ataatctgtg ctttgttggg     2100

ctcatctcca tgattgaccc tccacgggcg gccgttcctg atgccgtggg caaatgtcga     2160

agtgctggaa ttaaggtcat catggtcaca ggagaccatc caatcacagc taaagctatt     2220

gccaaaggtg tgggcatcat ctcagaaggc aatgagaccg tggaagacat tgctgcccgc     2280

ctcaacatcc cagtcagcca ggtgaacccc agggatgcca aggcctgcgt agtacacggc     2340

agtgatctaa aggacatgac ctccgagcag ctggatgaca ttttgaagta ccacactgag     2400

atagtgtttg ccaggacctc ccctcagcag aagctcatca ttgtggaagg ctgccaaaga     2460

cagggtgcta tcgtggctgt gactggtgac ggtgtgaatg actctccagc tttgaagaaa     2520

gcagacattg gggttgctat ggggattgct ggctcagatg tgtccaagca agctgctgac     2580

atgattcttc tggatgacaa ctttgcctca attgtgactg gagtagagga aggtcgtctg     2640

atctttgata acttgaagaa atccattgct tataccttaa ccagtaacat tcccgagatc     2700

accccgttcc tgatatttat tattgcaaac attccactac cactggggac tgtcaccatc     2760

ctctgcattg acttgggcac tgacatggtt cctgccatct ccctggctta tgagcaggct     2820

gagagtgaca tcatgaagag acagcccaga aatcccaaaa cagacaaact tgtgaatgag     2880

cggctgatca gcatggccta tgggcagatt ggaatgatcc aggccctggg aggcttcttt     2940

acttactttg tgattctggc tgagaacggc ttcctcccaa ttcacctgtt gggcctccga     3000

gtggactggg atgaccgctg gatcaacgat gtggaagaca gctacgggca gcagtggacc     3060

tatgagcaga ggaaaatcgt ggagttcacc tgccacacag ccttcttcgt cagtatcgtg     3120

gtggtgcagt gggccgactt ggtcatctgt aagaccagga ggaattcggt cttccagcag     3180

gggatgaaga acaagatctt gatatttggc ctctttgaag agacagccct ggctgctttc     3240

ctttcctact gccctggaat gggtgttgct cttaggatgt atcccctcaa acctacctgg     3300

tggttctgtg ccttccccta ctctcttctc atcttcgtat atgacgaagt cagaaaactc     3360

atcatcaggc gacgccctgg cggctgggtg gagaaggaaa cctactatta gccccccgtc     3420

ctgcacgccg tggagcatca ggccacacac tctgcatccg acacccaccc cctctttgtg     3480

tacttcagtc ttggagtttg gaactctacc ctggtaggaa agcaccgcag catgtgggga     3540

agcaagacgt cctggaatga agcatgtagc tctatggggg gaggggggag ggctgcctga     3600

aaaccatcca tctgtggaaa tgacagcggg gaaggttttt atgtgccttt ttgtttttgt     3660

aaaaaaggaa cacccggaaa gactgaaaga atacatttta tatctggatt tttacaaata     3720

aagatggcta ttataatgga aaaaaaaaaa aaaa                                 3754


<210>  8
<211>  2588
<212>  DNA
<213>  Homo Sapiens

<400>  8
gagctcgggc ggccggagct ggtcgctgcg cgcgccgggg ggagggccgg ggctgcgaga       60

gaggaagctc tttcgcggcg ctacggcgtt ggcaccagtc tctagaaaag aagtcagctc      120

tggttcggag aagcagcggc tggcgtgggc catccgggga atgggcgccc tcgtgaccta      180

gtgttgcggg gcaaaaaggg tcttgccggc ctcgctcgtg caggggcgta tctgggcgcc      240

tgagcgcggc gtgggagcct tgggagccgc cgcagcaggg ggcacacccg gaaccggcct      300

gagcgcccgg gaccatgaac ggggaggcca tctgcagcgc cctgcccacc attccctacc      360

acaaactcgc cgacctgcgc tacctgagcc gcggcgcctc tggcactgtg tcgtccgccc      420

gccacgcaga ctggcgcgtc caggtggccg tgaagcacct gcacatccac actccgctgc      480

tcgacagtga aagaaaggat gtcttaagag aagctgaaat tttacacaaa gctagattta      540

gttacattct tccaattttg ggaatttgca atgagcctga atttttggga atagttactg      600

aatacatgcc aaatggatca ttaaatgaac tcctacatag gaaaactgaa tatcctgatg      660

ttgcttggcc attgagattt cgcatcctgc atgaaattgc ccttggtgta aattacctgc      720

acaatatgac tcctccttta cttcatcatg acttgaagac tcagaatatc ttattggaca      780

atgaatttca tgttaagatt gcagattttg gtttatcaaa gtggcgcatg atgtccctct      840

cacagtcacg aagtagcaaa tctgcaccag aaggagggac aattatctat atgccacctg      900

aaaactatga acctggacaa aaatcaaggg ccagtatcaa gcacgatata tatagctatg      960

cagttatcac atgggaagtg ttatccagaa aacagccttt tgaagatgtc accaatcctt     1020

tgcagataat gtatagtgtg tcacaaggac atcgacctgt tattaatgaa gaaagtttgc     1080

catatgatat acctcaccga gcacgtatga tctctctaat agaaagtgga tgggcacaaa     1140

atccagatga aagaccatct ttcttaaaat gtttaataga acttgaacca gttttgagaa     1200

catttgaaga gataactttt cttgaagctg ttattcagct aaagaaaaca aagttacaga     1260

gtgtttcaag tgccattcac ctatgtgaca agaagaaaat ggaattatct ctgaacatac     1320

ctgtaaatca tggtccacaa gaggaatcat gtggatcctc tcagctccat gaaaatagtg     1380

gttctcctga aacttcaagg tccctgccag ctcctcaaga caatgatttt ttatctagaa     1440

aagctcaaga ctgttatttt atgaagctgc atcactgtcc tggaaatcac agttgggata     1500

gcaccatttc tggatctcaa agggctgcat tctgtgatca caagaccact ccatgctctt     1560

cagcaataat aaatccactc tcaactgcag gaaactcaga acgtctgcag cctggtatag     1620

cccagcagtg gatccagagc aaaagggaag acattgtgaa ccaaatgaca gaagcctgcc     1680

ttaaccagtc gctagatgcc cttctgtcca gggacttgat catgaaagag gactatgaac     1740

ttgttagtac caagcctaca aggacctcaa aagtcagaca attactagac actactgaca     1800

tccaaggaga agaatttgcc aaagttatag tacaaaaatt gaaagataac aaacaaatgg     1860

gtcttcagcc ttacccggaa atacttgtgg tttctagatc accatcttta aatttacttc     1920

aaaataaaag catgtaagtg actgtttttc aagaagaaat gtgtttcata aaaggatatt     1980

tatatctctg ttgctttgac tttttttata taaaatccgt gagtattaaa gctttattga     2040

aggttctttg ggtaaatatt agtctccctc catgacactg cagtattttt tttaattaat     2100

acaagtaaaa agtttgaatt ttgctacata gttcaatttt tatgtctctt ttgttaacag     2160

aaaccacttt taaaggatag taattattct tgtttataac agtgccttaa ggtatgatgt     2220

atttctgatg gaagccattt tcacattcat gttcttcatg gattatttgt tacttgtcta     2280

agatgcaatt tgattttatg aagtatatac cctttaccca ccagagacag tacagaatcc     2340

ctgccctaaa atcccaggct taattgccct acaaagggtt attaatttaa aactccatta     2400

ttaggattac attttaaagt tttatttatg aattcccttt aaaaatgata tttcaaaggt     2460

aaaacaatac aatataaaga aaaaaataaa tatattaata ccggcttcct gtccccattt     2520

ttaacctcag ccttccctac tgtcaccaac aaccaagcta aataaagtca acagcctgat     2580

gtgtaaaa                                                              2588


<210>  9
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  10
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  11
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  12
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  12

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Phe Leu 
            100                 105                 110         


Gly Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  13
<211>  1023
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  14
<211>  992
<212>  PRT
<213>  Homo Sapiens

<400>  14

Met Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser 
1               5                   10                  15      


Leu Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu 
            20                  25                  30          


Thr Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala 
        35                  40                  45              


Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln 
    50                  55                  60                  


Leu Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys 
65                  70                  75                  80  


Phe Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn 
                85                  90                  95      


Asp Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr 
            100                 105                 110         


Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu 
        115                 120                 125             


Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly 
    130                 135                 140                 


Glu Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val 
145                 150                 155                 160 


Glu Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser 
                165                 170                 175     


Ala Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu 
            180                 185                 190         


Pro Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr 
        195                 200                 205             


Arg Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg 
    210                 215                 220                 


Gly Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala 
225                 230                 235                 240 


Thr Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu 
                245                 250                 255     


Ile Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly 
            260                 265                 270         


Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu 
        275                 280                 285             


Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly 
    290                 295                 300                 


Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met 
305                 310                 315                 320 


Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu 
                325                 330                 335     


Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln 
            340                 345                 350         


Asn Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu 
        355                 360                 365             


Ala Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser 
    370                 375                 380                 


Ala Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala 
385                 390                 395                 400 


Val Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val 
                405                 410                 415     


Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys 
            420                 425                 430         


Cys Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu 
        435                 440                 445             


Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn 
    450                 455                 460                 


Pro Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro 
465                 470                 475                 480 


Glu Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu 
                485                 490                 495     


Gln Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu 
            500                 505                 510         


Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe 
        515                 520                 525             


Leu Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp 
    530                 535                 540                 


Val Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met 
545                 550                 555                 560 


Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg 
                565                 570                 575     


Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr 
            580                 585                 590         


Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu 
        595                 600                 605             


Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val 
    610                 615                 620                 


Asn Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys 
625                 630                 635                 640 


Asp Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu 
                645                 650                 655     


Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu 
            660                 665                 670         


Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val 
        675                 680                 685             


Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly 
    690                 695                 700                 


Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu 
705                 710                 715                 720 


Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu 
                725                 730                 735     


Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn 
            740                 745                 750         


Ile Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro 
        755                 760                 765             


Leu Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp 
    770                 775                 780                 


Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile 
785                 790                 795                 800 


Met Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu 
                805                 810                 815     


Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu 
            820                 825                 830         


Gly Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu 
        835                 840                 845             


Pro Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile 
    850                 855                 860                 


Asn Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg 
865                 870                 875                 880 


Lys Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val 
                885                 890                 895     


Val Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser 
            900                 905                 910         


Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe 
        915                 920                 925             


Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly 
    930                 935                 940                 


Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala 
945                 950                 955                 960 


Phe Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu 
                965                 970                 975     


Ile Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
            980                 985                 990         


<210>  15
<211>  1023
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  16
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Asn Gly Glu Ala Ile Cys Ser Ala Leu Pro Thr Ile Pro Tyr His 
1               5                   10                  15      


Lys Leu Ala Asp Leu Arg Tyr Leu Ser Arg Gly Ala Ser Gly Thr Val 
            20                  25                  30          


Ser Ser Ala Arg His Ala Asp Trp Arg Val Gln Val Ala Val Lys His 
        35                  40                  45              


Leu His Ile His Thr Pro Leu Leu Asp Ser Glu Arg Lys Asp Val Leu 
    50                  55                  60                  


Arg Glu Ala Glu Ile Leu His Lys Ala Arg Phe Ser Tyr Ile Leu Pro 
65                  70                  75                  80  


Ile Leu Gly Ile Cys Asn Glu Pro Glu Phe Leu Gly Ile Val Thr Glu 
                85                  90                  95      


Tyr Met Pro Asn Gly Ser Leu Asn Glu Leu Leu His Arg Lys Thr Glu 
            100                 105                 110         


Tyr Pro Asp Val Ala Trp Pro Leu Arg Phe Arg Ile Leu His Glu Ile 
        115                 120                 125             


Ala Leu Gly Val Asn Tyr Leu His Asn Met Thr Pro Pro Leu Leu His 
    130                 135                 140                 


His Asp Leu Lys Thr Gln Asn Ile Leu Leu Asp Asn Glu Phe His Val 
145                 150                 155                 160 


Lys Ile Ala Asp Phe Gly Leu Ser Lys Trp Arg Met Met Ser Leu Ser 
                165                 170                 175     


Gln Ser Arg Ser Ser Lys Ser Ala Pro Glu Gly Gly Thr Ile Ile Tyr 
            180                 185                 190         


Met Pro Pro Glu Asn Tyr Glu Pro Gly Gln Lys Ser Arg Ala Ser Ile 
        195                 200                 205             


Lys His Asp Ile Tyr Ser Tyr Ala Val Ile Thr Trp Glu Val Leu Ser 
    210                 215                 220                 


Arg Lys Gln Pro Phe Glu Asp Val Thr Asn Pro Leu Gln Ile Met Tyr 
225                 230                 235                 240 


Ser Val Ser Gln Gly His Arg Pro Val Ile Asn Glu Glu Ser Leu Pro 
                245                 250                 255     


Tyr Asp Ile Pro His Arg Ala Arg Met Ile Ser Leu Ile Glu Ser Gly 
            260                 265                 270         


Trp Ala Gln Asn Pro Asp Glu Arg Pro Ser Phe Leu Lys Cys Leu Ile 
        275                 280                 285             


Glu Leu Glu Pro Val Leu Arg Thr Phe Glu Glu Ile Thr Phe Leu Glu 
    290                 295                 300                 


Ala Val Ile Gln Leu Lys Lys Thr Lys Leu Gln Ser Val Ser Ser Ala 
305                 310                 315                 320 


Ile His Leu Cys Asp Lys Lys Lys Met Glu Leu Ser Leu Asn Ile Pro 
                325                 330                 335     


Val Asn His Gly Pro Gln Glu Glu Ser Cys Gly Ser Ser Gln Leu His 
            340                 345                 350         


Glu Asn Ser Gly Ser Pro Glu Thr Ser Arg Ser Leu Pro Ala Pro Gln 
        355                 360                 365             


Asp Asn Asp Phe Leu Ser Arg Lys Ala Gln Asp Cys Tyr Phe Met Lys 
    370                 375                 380                 


Leu His His Cys Pro Gly Asn His Ser Trp Asp Ser Thr Ile Ser Gly 
385                 390                 395                 400 


Ser Gln Arg Ala Ala Phe Cys Asp His Lys Thr Thr Pro Cys Ser Ser 
                405                 410                 415     


Ala Ile Ile Asn Pro Leu Ser Thr Ala Gly Asn Ser Glu Arg Leu Gln 
            420                 425                 430         


Pro Gly Ile Ala Gln Gln Trp Ile Gln Ser Lys Arg Glu Asp Ile Val 
        435                 440                 445             


Asn Gln Met Thr Glu Ala Cys Leu Asn Gln Ser Leu Asp Ala Leu Leu 
    450                 455                 460                 


Ser Arg Asp Leu Ile Met Lys Glu Asp Tyr Glu Leu Val Ser Thr Lys 
465                 470                 475                 480 


Pro Thr Arg Thr Ser Lys Val Arg Gln Leu Leu Asp Thr Thr Asp Ile 
                485                 490                 495     


Gln Gly Glu Glu Phe Ala Lys Val Ile Val Gln Lys Leu Lys Asp Asn 
            500                 505                 510         


Lys Gln Met Gly Leu Gln Pro Tyr Pro Glu Ile Leu Val Val Ser Arg 
        515                 520                 525             


Ser Pro Ser Leu Asn Leu Leu Gln Asn Lys Ser Met 
    530                 535                 540 


<210>  17
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  17
accttatcag aaagctctc                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  18
tggctcatag cctttcatc                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  19
tctccgctat acagaagac                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  20
tatctatact ggtgattcc                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  21
ccataggttt aatgatgtc                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  22
tagtgcagtt gccattgtc                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  23
cttgcaccac ttcaacctc                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  24
tggcaacagt ctgtttgac                                                    19


<210>  25
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  25
agcaaacttg caccacttc                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  26
ctacacggca tacaagtac                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  27
tgagagcgac gaagccaac                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  28
cgtggaagac attgctgcc                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  29
gactaggtct ccagatttc                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  30
acgtggtatt gttgtctac                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  31
ggcagtgttt caggctaac                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  32
caggagacca tccaatcac                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  33
tcaagggcca gtatcaagc                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  34
gaattatctc tgaacatac                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  35
caaagctaga tttagttac                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  36
tcacatggga agtgttatc                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Homo Sapiens

<400>  37
gatgtcacca atcctttgc                                                    19


<210>  38
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  38
guuugcuaua ac                                                           12


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  39
ccgtttacgt ggagactcgc c                                                 21


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  40
cccccacctt atatatattc tttcc                                             25


