                         SEQUENCE LISTING

<110>  Universidad de Salamanca
 
<120>  METHOD FOR THE DETECTION OF RENAL DAMAGE

<130>  PCT1367.34

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  2
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  3
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Phe Ile Ala Ala Leu Gly Leu Leu Met Ala Gly Ile Cys Pro 
1               5                   10                  15      


Ala Val Leu Cys Asp Gly Thr Leu Gly Arg Asp Thr Leu Ser His Glu 
            20                  25                  30          


Asp His Gly Lys Gly Arg Gln Leu His Ser Leu Thr Leu Ala Ser Ser 
        35                  40                  45              


Asn Thr Asp Phe Ala Leu Ser Leu Tyr Lys Lys Leu Ala Leu Arg Asn 
    50                  55                  60                  


Pro Asp Lys Asn Val Val Phe Ser Pro Leu Ser Ile Ser Ala Ala Leu 
65                  70                  75                  80  


Thr Ile Leu Ser Leu Gly Ala Lys Asp Ser Thr Met Glu Glu Ile Leu 
                85                  90                  95      


Glu Gly Leu Lys Phe Asn Leu Thr Glu Ile Thr Glu Glu Glu Ile His 
            100                 105                 110         


Gln Gly Phe Gly His Leu Leu Gln Arg Leu Ser Gln Pro Glu Asp Gln 
        115                 120                 125             


Val Glu Ile Asn Thr Gly Ser Ala Leu Phe Ile Asp Lys Glu Gln Pro 
    130                 135                 140                 


Ile Leu Ser Glu Phe Gln Glu Lys Thr Arg Ala Leu Tyr Gln Ala Glu 
145                 150                 155                 160 


Ala Phe Val Ala Asp Phe Lys Gln Pro Asn Glu Ala Lys Lys Leu Ile 
                165                 170                 175     


Asn Asp Tyr Val Ser Asn Gln Thr Gln Gly Lys Ile Ala Glu Leu Phe 
            180                 185                 190         


Ser Asp Leu Glu Glu Arg Thr Ser Met Val Leu Val Asn Tyr Leu Leu 
        195                 200                 205             


Phe Lys Gly Lys Trp Lys Ala Pro Phe Asn Pro Asn Asp Thr Ile Glu 
    210                 215                 220                 


Ser Glu Phe Tyr Leu Asp Glu Lys Arg Ser Val Lys Val Pro Met Met 
225                 230                 235                 240 


Lys Ile Lys Glu Val Thr Thr Pro Tyr Val Arg Asp Glu Glu Leu Ser 
                245                 250                 255     


Cys Ser Val Leu Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala Leu Phe 
            260                 265                 270         


Ile Leu Pro Asp Gln Gly Lys Met Gln Gln Val Glu Ser Ser Leu Gln 
        275                 280                 285             


Pro Glu Thr Leu Lys Lys Trp Lys Asp Ser Leu Ile Pro Arg Ile Ile 
    290                 295                 300                 


Asn Asp Leu Arg Met Pro Lys Phe Ser Ile Ser Thr Asp Tyr Ser Leu 
305                 310                 315                 320 


Lys Glu Val Leu Pro Glu Leu Gly Ile Lys Lys Val Phe Ser Gln Gln 
                325                 330                 335     


Ala Asp Leu Ser Arg Ile Thr Gly Thr Lys Asp Leu Tyr Val Ser Gln 
            340                 345                 350         


Val Val His Lys Ala Val Leu Asp Val Asp Glu Thr Gly Thr Glu Ala 
        355                 360                 365             


Thr Ala Ala Thr Gly Val Ala Thr Val Ile Arg Arg Gln Pro Arg Thr 
    370                 375                 380                 


Leu Asn Phe Asn Arg Pro Phe Met Val Val Ile Thr Asp Met Asp Ser 
385                 390                 395                 400 


Gln Ser Ile Leu Phe Val Ala Lys Ile Thr Asn Pro Lys 
                405                 410             


<210>  4
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln 
1               5                   10                  15      


Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr 
            20                  25                  30          


Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met 
        35                  40                  45              


Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys 
    50                  55                  60                  


Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala 
65                  70                  75                  80  


Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val 
                85                  90                  95      


Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys 
            100                 105                 110         


Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val 
        115                 120                 125             


Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr 
    130                 135                 140                 


His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro 
145                 150                 155                 160 


Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser 
                165                 170                 175     


Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Ser 
            180                 185                 190         


Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr 
        195                 200                 205             


Val Ala Ser Ala Asp Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp 
    210                 215                 220                 


Val Leu Gln Asn Tyr Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr 
225                 230                 235                 240 


Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala 
                245                 250                 255     


Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr 
            260                 265                 270         


Leu Thr Phe Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile 
        275                 280                 285             


Glu Ile Ile Ser Gly Ala Ala Ala Leu Asp 
    290                 295             


<210>  5
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  6
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly 
1               5                   10                  15      


Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr 
            20                  25                  30          


Ile Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser 
        35                  40                  45              


Gly Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu 
    50                  55                  60                  


Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr 
65                  70                  75                  80  


Val Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr 
                85                  90                  95      


Lys Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val 
            100                 105                 110         


Ala Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile 
        115                 120                 125             


Gln Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135         


<210>  7
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe 
1               5                   10                  15      


Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly 
            20                  25                  30          


Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly 
        35                  40                  45              


Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr 
    50                  55                  60                  


Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His 
65                  70                  75                  80  


Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe 
                85                  90                  95      


Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln 
            100                 105                 110         


Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu 
        115                 120                 125             


Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val 
    130                 135                 140                 


Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln 
145                 150                 155                 160 


Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly 
                165                 170                 175     


Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser 
            180                 185                 190         


Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser 
        195                 200                 205             


Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn 
    210                 215                 220                 


Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn 
225                 230                 235                 240 


Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu 
                245                 250                 255     


Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser 
            260                 265                 270         


Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu 
        275                 280                 285             


Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu 
    290                 295                 300                 


Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser 
305                 310                 315                 320 


Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu 
                325                 330                 335     


Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile 
            340                 345                 350         


Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr 
        355                 360                 365             


Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe 
    370                 375                 380                 


Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser 
385                 390                 395                 400 


Val Pro Ala Leu Pro Ser Asp Ser 
                405             


<210>  8
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly Val 
1               5                   10                  15      


Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu 
            20                  25                  30          


Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu Pro 
        35                  40                  45              


Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys 
    50                  55                  60                  


Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe 
65                  70                  75                  80  


Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn 
                85                  90                  95      


Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu 
            100                 105                 110         


Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu 
        115                 120                 125             


Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile 
    130                 135                 140                 


Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp 
145                 150                 155                 160 


Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp 
                165                 170                 175     


Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val 
            180                 185                 190         


Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys 
        195                 200                 205             


Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val 
    210                 215                 220                 


Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn 
225                 230                 235                 240 


Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu 
                245                 250                 255     


Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser 
            260                 265                 270         


His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val 
        275                 280                 285             


Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu 
    290                 295                 300                 


Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly 
305                 310                 315                 320 


Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys 
                325                 330                 335     


<210>  9
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  10
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Met Thr Asp Leu Leu Asn Ala Glu Asp Ile Lys Lys Ala Val 
1               5                   10                  15      


Gly Ala Phe Ser Ala Thr Asp Ser Phe Asp His Lys Lys Phe Phe Gln 
            20                  25                  30          


Met Val Gly Leu Lys Lys Lys Ser Ala Asp Asp Val Lys Lys Val Phe 
        35                  40                  45              


His Met Leu Asp Lys Asp Lys Ser Gly Phe Ile Glu Glu Asp Glu Leu 
    50                  55                  60                  


Gly Phe Ile Leu Lys Gly Phe Ser Pro Asp Ala Arg Asp Leu Ser Ala 
65                  70                  75                  80  


Lys Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp Gly Asp Gly 
                85                  90                  95      


Lys Ile Gly Val Asp Glu Phe Ser Thr Leu Val Ala Glu Ser 
            100                 105                 110 


<210>  11
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Asp Gly Met Tyr Gln Arg Phe Leu Arg Gln His Val His Pro Glu 
1               5                   10                  15      


Glu Thr Gly Gly Ser Asp Arg Tyr Cys Asp Leu Met Met Gln Arg Arg 
            20                  25                  30          


Lys Met Thr Leu Tyr His Cys Lys Arg Phe Asn Thr Phe Ile His Glu 
        35                  40                  45              


Asp Ile Trp Asn Ile Arg Ser Ile Cys Ser Thr Thr Asn Ile Gln Cys 
    50                  55                  60                  


Lys Asn Gly Lys Met Asn Cys His Glu Gly Val Val Lys Val Thr Asp 
65                  70                  75                  80  


Cys Arg Asp Thr Gly Ser Ser Arg Ala Pro Asn Cys Arg Tyr Arg Ala 
                85                  90                  95      


Ile Ala Ser Thr Arg Arg Val Val Ile Ala Cys Glu Gly Asn Pro Gln 
            100                 105                 110         


Val Pro Val His Phe Asp Gly 
        115                 


<210>  12
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Phe Ile Ala Ala Leu Gly Leu Leu Met Ala Gly Ile Cys Pro 
1               5                   10                  15      


Ala Val Leu Cys Asp Gly Thr Leu Gly Arg Asp Thr Leu Ser His Glu 
            20                  25                  30          


Asp His Gly Lys Gly Arg Gln Leu His Ser Leu Thr Leu Ala Ser Ser 
        35                  40                  45              


Asn Thr Asp Phe Ala Leu Ser Leu Tyr Lys Lys Leu Ala Leu Arg Asn 
    50                  55                  60                  


Pro Asp Lys Asn Val Val Phe Ser Pro Leu Ser Ile Ser Ala Ala Leu 
65                  70                  75                  80  


Thr Ile Leu Ser Leu Gly Ala Lys Asp Ser Thr Met Glu Glu Ile Leu 
                85                  90                  95      


Glu Gly Leu Lys Phe Asn Leu Thr Glu Ile Thr Glu Glu Glu Ile His 
            100                 105                 110         


Gln Gly Phe Gly His Leu Leu Gln Arg Leu Ser Gln Pro Glu Asp Gln 
        115                 120                 125             


Val Glu Ile Asn Thr Gly Ser Ala Leu Phe Ile Asp Lys Glu Gln Pro 
    130                 135                 140                 


Ile Leu Ser Glu Phe Gln Glu Lys Thr Arg Ala Leu Tyr Gln Ala Glu 
145                 150                 155                 160 


Ala Phe Val Ala Asp Phe Lys Gln Pro Asn Glu Ala Lys Lys Leu Ile 
                165                 170                 175     


Asn Asp Tyr Val Ser Asn Gln Thr Gln Gly Lys Ile Ala Glu Leu Phe 
            180                 185                 190         


Ser Asp Leu Glu Glu Arg Thr Ser Met Val Leu Val Asn Tyr Leu Leu 
        195                 200                 205             


Phe Lys Gly Lys Trp Lys Ala Pro Phe Asn Pro Asn Asp Thr Ile Glu 
    210                 215                 220                 


Ser Glu Phe Tyr Leu Asp Glu Lys Arg Ser Val Lys Val Pro Met Met 
225                 230                 235                 240 


Lys Ile Lys Glu Val Thr Thr Pro Tyr Val Arg Asp Glu Glu Leu Ser 
                245                 250                 255     


Cys Ser Val Leu Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala Leu Phe 
            260                 265                 270         


Ile Leu Pro Asp Gln Gly Lys Met Gln Gln Val Glu Ser Ser Leu Gln 
        275                 280                 285             


Pro Glu Thr Leu Lys Lys Trp Lys Asp Ser Leu Ile Pro Arg Ile Ile 
    290                 295                 300                 


Asn Asp Leu Arg Met Pro Lys Phe Ser Ile Ser Thr Asp Tyr Ser Leu 
305                 310                 315                 320 


Lys Glu Val Leu Pro Glu Leu Gly Ile Lys Lys Val Phe Ser Gln Gln 
                325                 330                 335     


Ala Asp Leu Ser Arg Ile Thr Gly Thr Lys Asp Leu Tyr Val Ser Gln 
            340                 345                 350         


Val Val His Lys Ala Val Leu Asp Val Asp Glu Thr Gly Thr Glu Ala 
        355                 360                 365             


Thr Ala Ala Thr Gly Val Ala Thr Val Ile Arg Arg Gln Pro Arg Thr 
    370                 375                 380                 


Leu Asn Phe Asn Arg Pro Phe Met Val Val Ile Thr Asp Met Asp Ser 
385                 390                 395                 400 


Gln Ser Ile Leu Phe Val Ala Lys Ile Thr Asn Pro Lys 
                405                 410             


<210>  13
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Leu Pro Val Gln Val Phe Asn Leu Gln Gly Ala Val Glu Pro 
1               5                   10                  15      


Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp 
            20                  25                  30          


Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala 
        35                  40                  45              


Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala 
    50                  55                  60                  


Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser 
65                  70                  75                  80  


Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg 
                85                  90                  95      


Lys Leu Ser Glu Ala Thr Arg Ser Ser Leu Arg Glu Leu Gln Asn Ala 
            100                 105                 110         


Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr 
        115                 120                 125             


Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys 
    130                 135                 140                 


Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser 
145                 150                 155                 160 


Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly 
                165                 170                 175     


Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys 
            180                 185                 190         


Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val 
        195                 200                 205             


Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys 
    210                 215                 220                 


Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser 
225                 230                 235                 240 


Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala 
                245                 250                 255     


Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu 
            260                 265                 270         


Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn 
        275                 280                 285             


Val Ala Ile Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln 
    290                 295                 300                 


Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu 
305                 310                 315                 320 


Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser 
                325                 330                 335     


Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu 
            340                 345                 350         


Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln 
        355                 360                 365             


Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala 
    370                 375                 380                 


Asp Met His Arg Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu 
385                 390                 395                 400 


Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg 
                405                 410                 415     


Val Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg 
            420                 425                 430         


Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg 
        435                 440                 445             


Arg Ala Lys Ala Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile 
    450                 455                 460                 


His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro 
465                 470                 475                 480 


Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met 
                485                 490     


<210>  14
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Asn Thr Ala Met Lys Lys Lys Val Leu Leu Met Gly Lys Ser 
1               5                   10                  15      


Gly Ser Gly Lys Thr Ser Met Arg Ser Ile Ile Phe Ala Asn Tyr Ile 
            20                  25                  30          


Ala Arg Asp Thr Arg Arg Leu Gly Ala Thr Ile Asp Val Glu His Ser 
        35                  40                  45              


His Val Arg Phe Leu Gly Asn Leu Val Leu Asn Leu Trp Asp Cys Gly 
    50                  55                  60                  


Gly Gln Asp Thr Phe Met Glu Asn Tyr Phe Thr Ser Gln Arg Asp Asn 
65                  70                  75                  80  


Ile Phe Arg Asn Val Glu Val Leu Ile Tyr Val Phe Asp Val Glu Ser 
                85                  90                  95      


Arg Glu Leu Glu Lys Asp Met His Tyr Tyr Gln Ser Cys Leu Glu Ala 
            100                 105                 110         


Ile Leu Gln Asn Ser Pro Asp Ala Lys Ile Phe Cys Leu Val His Lys 
        115                 120                 125             


Met Asp Leu Val Gln Glu Asp Gln Arg Asp Leu Ile Phe Lys Glu Arg 
    130                 135                 140                 


Glu Glu Asp Leu Arg Arg Leu Ser Arg Pro Leu Glu Cys Ala Cys Phe 
145                 150                 155                 160 


Arg Thr Ser Ile Trp Asp Glu Thr Leu Tyr Lys Ala Trp Ser Ser Ile 
                165                 170                 175     


Val Tyr Gln Leu Ile Pro Asn Val Gln Gln Leu Glu Met Asn Leu Arg 
            180                 185                 190         


Asn Phe Ala Gln Ile Ile Glu Ala Asp Glu Val Leu Leu Phe Glu Arg 
        195                 200                 205             


Ala Thr Phe Leu Val Ile Ser His Tyr Gln Cys Lys Glu Gln Arg Asp 
    210                 215                 220                 


Val His Arg Phe Glu Lys Ile Ser Asn Ile Ile Lys Gln Phe Lys Leu 
225                 230                 235                 240 


Ser Cys Ser Lys Leu Ala Ala Ser Phe Gln Ser Met Glu Val Arg Asn 
                245                 250                 255     


Ser Asn Phe Ala Ala Phe Ile Asp Ile Phe Thr Ser Asn Thr Tyr Val 
            260                 265                 270         


Met Val Val Met Ser Asp Pro Ser Ile Pro Ser Ala Ala Thr Leu Ile 
        275                 280                 285             


Asn Ile Arg Asn Ala Arg Lys His Phe Glu Lys Leu Glu Arg Val Asp 
    290                 295                 300                 


Gly Pro Lys His Ser Leu Leu Met Arg 
305                 310             


<210>  15
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  15
ttgtttgatg cagaactggc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  16
agacgtaggg caacttcact                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  17
caaggctact tcaagtctgg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  18
gctaccctct tcagacacat                                                   20


<210>  19
<211>  19
<212>  DNA
<213>  Rattus norvegicus

<400>  19
gtggtcatga gcccttcca                                                    19


<210>  20
<211>  23
<212>  DNA
<213>  Rattus norvegicus

<400>  20
aactccctca agattgtcag caa                                               23


