                              Sequence Listing

<110> GENENTECH, INC.
      FERRARA, Napoleone
      KOWANETZ, Marcin Leszek

<120> INHIBITION OF TUMOR METASTASIS

<130> P4348R1 WO

<141> 2010-07-30

<150> US 61/230,571
<151> 2009-07-31

<150> US 61/350,558
<151> 2010-06-02

<160> 19

<210> 1
<211> 427
<212> DNA
<213> Homo sapiens

<400> 1
 tgagggcgcc atgaggagcc tgtgctgcgc cccactcctg ctcctcttgc 50

 tgctgccgcc gctgctgctc acgccccgcg ctggggacgc cgccgtgatc 100

 accggggctt gtgacaagga ctcccaatgt ggtggaggca tgtgctgtgc 150

 tgtcagtatc tgggtcaaga gcataaggat ttgcacacct atgggcaaac 200

 tgggagacag ctgccatcca ctgactcgta aaaacaattt tggaaatgga 250

 aggcaggaaa gaagaaagag gaagagaagc aaaaggaaaa aggaggttcc 300

 attttttggg cggaggatgc atcacacttg cccatgtctg ccaggcttgg 350

 cctgtttacg gacttcattt aaccgattta tttgtttagc ccaaaagtaa 400

 tcgctctgga gtagaaacca  aatgtga 427

<210> 2
<211> 129
<212> PRT
<213> Homo sapiens

<400> 2
 Met Arg Ser Leu Cys Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu
   1               5                  10                  15

 Pro Pro Leu Leu Leu Thr Pro Arg Ala Gly Asp Ala Ala Val Ile
                  20                  25                  30

 Thr Gly Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys
                  35                  40                  45

 Cys Ala Val Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro
                  50                  55                  60

 Met Gly Lys Leu Gly Asp Ser Cys His Pro Leu Thr Arg Lys Asn
                  65                  70                  75

 Asn Phe Gly Asn Gly Arg Gln Glu Arg Arg Lys Arg Lys Arg Ser
                  80                  85                  90

 Lys Arg Lys Lys Glu Val Pro Phe Phe Gly Arg Arg Met His His
                  95                 100                 105

 Thr Cys Pro Cys Leu Pro Gly Leu Ala Cys Leu Arg Thr Ser Phe
                 110                 115                 120

 Asn Arg Phe Ile Cys Leu Ala Gln Lys
                 125                

<210> 3
<211> 363
<212> DNA
<213> Homo sapiens

<400> 3
 gagggcgcca tgaggagcct gtgctgcgcc ccactcctgc tcctcttgct 50

 gctgccgccg ctgctgctca cgccccgcgc tggggacgcc gccgtgatca 100

 ccggggcttg tgacaaggac tcccaatgtg gtggaggcat gtgctgtgct 150

 gtcagtatct gggtcaagag cataaggatt tgcacaccta tgggcaaact 200

 gggagacagc tgccatccac tgactcgtaa agttccattt tttgggcgga 250

 ggatgcatca cacttgccca tgtctgccag gcttggcctg tttacggact 300

 tcatttaacc gatttatttg tttagcccaa aagtaatcgc tctggagtag 350

 aaaccaaatg  tga 363

<210> 4
<211> 108
<212> PRT
<213> Homo sapiens

<400> 4
 Met Arg Ser Leu Cys Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu
   1               5                  10                  15

 Pro Pro Leu Leu Leu Thr Pro Arg Ala Gly Asp Ala Ala Val Ile
                  20                  25                  30

 Thr Gly Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys
                  35                  40                  45

 Cys Ala Val Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro
                  50                  55                  60

 Met Gly Lys Leu Gly Asp Ser Cys His Pro Leu Thr Arg Lys Val
                  65                  70                  75

 Pro Phe Phe Gly Arg Arg Met His His Thr Cys Pro Cys Leu Pro
                  80                  85                  90

 Gly Leu Ala Cys Leu Arg Thr Ser Phe Asn Arg Phe Ile Cys Leu
                  95                 100                 105

 Ala Gln Lys
            

<210> 5
<211> 1338
<212> DNA
<213> Mouse

<400> 5
 cggacgcgtg ggcgtcccct aaccgccacc gcgtccccgg gacgccatgg 50

 gggacccgcg ctgtgccccg ctactgctac ttctgctgct accgctgctg 100

 ttcacaccgc ccgccgggga tgccgcggtc atcaccgggg cttgcgacaa 150

 ggactctcag tgcggaggag gcatgtgctg tgctgtcagt atctgggtta 200

 agagcataag gatctgcaca cctatgggcc aagtgggcga cagctgccac 250

 cccctgactc ggaaagttcc attttggggg cggaggatgc accacacctg 300

 cccctgcctg ccaggcttgg cgtgtttaag gacttctttc aaccggttta 350

 tttgcttggc ccggaaatga tcactctgaa gtaggaactt gaaatgcgac 400

 cctccgctgc acaatgtccg tcgagtctca cttgtaattg tggcaaacaa 450

 agaatactcc agaaagaaat gttctccccc ttccttgact ttccaagtaa 500

 cgtttctatc tttgattttt gaagtggctt tttttttttt ttttttttcc 550

 tttccttgaa ggaaagtttt gatttttgga gagatttata gaggactttc 600

 tgacatggct tctcatttcc ctgtttatgt tttgccttga catttttgaa 650

 tgccaataac aactgttttc acaaatagga gaataagagg gaacaatctg 700

 ttgcagaaac ttccttttgc cctttgcccc actcgccccg ccccgccccg 750

 ccccgccctg cccatgcgca gacagacaca cccttactct tcaaagactc 800

 tgatgatcct caccttactg tagcattgtg ggtttctaca cttccccgcc 850

 ttgctggtgg acccactgag gaggctcaga gagctagcac tgtacaggtt 900

 tgaaccagat cccccaagca gctcatttgg ggcagacgtt gggagcgctc 950

 caggaacttt cctgcaccca tctggcccac tggctttcag ttctgctgtt 1000

 taactggtgg gaggacaaaa ttaacgggac cctgaaggaa cctggcccgt 1050

 ttatctagat ttgtttaagt aaaagacatt ttctccttgt tgtggaatat 1100

 tacatgtctt tttctttttt atctgaagct tttttttttt ttctttaagt 1150

 cttcttgttg gagacatttt aaagaacgcc actcgaggaa gcattgattt 1200

 tcatytggca tgacaggagt catcatttta aaaaatcggt gttaagttat 1250

 aatttaaact ttatttgtaa cccaaaggty taatgtaaat ggatttcctg 1300

 atatcctgcc atttgtactg gtatcaatat  ttytatgt 1338

<210> 6
<211> 107
<212> PRT
<213> Mouse

<400> 6
 Met Gly Asp Pro Arg Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu
   1               5                  10                  15

 Pro Leu Leu Phe Thr Pro Pro Ala Gly Asp Ala Ala Val Ile Thr
                  20                  25                  30

 Gly Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys
                  35                  40                  45

 Ala Val Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met
                  50                  55                  60

 Gly Gln Val Gly Asp Ser Cys His Pro Leu Thr Arg Lys Val Pro
                  65                  70                  75

 Phe Trp Gly Arg Arg Met His His Thr Cys Pro Cys Leu Pro Gly
                  80                  85                  90

 Leu Ala Cys Leu Arg Thr Ser Phe Asn Arg Phe Ile Cys Leu Ala
                  95                 100                 105

 Arg Lys
        

<210> 7
<211> 624
<212> DNA
<213> Homo sapiens

<400> 7
 atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct 50

 gctgctgtgg cacagtgcac tctggacagt gcaggaagcc acccccctgg 100

 gccctgccag ctccctgccc cagagcttcc tgctcaagtg cttagagcaa 150

 gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctggtgag 200

 tgagtgtgcc acctacaagc tgtgccaccc cgaggagctg gtgctgctcg 250

 gacactctct gggcatcccc tgggctcccc tgagcagctg ccccagccag 300

 gccctgcagc tggcaggctg cttgagccaa ctccatagcg gccttttcct 350

 ctaccagggg ctcctgcagg ccctggaagg gatctccccc gagttgggtc 400

 ccaccttgga cacactgcag ctggacgtcg ccgactttgc caccaccatc 450

 tggcagcaga tggaagaact gggaatggcc cctgccctgc agcccaccca 500

 gggtgccatg ccggccttcg cctctgcttt ccagcgccgg gcaggagggg 550

 tcctggttgc ctcccatctg cagagcttcc tggaggtgtc gtaccgcgtt 600

 ctacgccacc ttgcccagcc  ctga 624

<210> 8
<211> 207
<212> PRT
<213> Homo sapiens

<400> 8
 Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu
   1               5                  10                  15

 Gln Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala
                  20                  25                  30

 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu
                  35                  40                  45

 Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala
                  50                  55                  60

 Leu Gln Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys
                  65                  70                  75

 His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro
                  80                  85                  90

 Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala
                  95                 100                 105

 Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly
                 110                 115                 120

 Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr
                 125                 130                 135

 Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile
                 140                 145                 150

 Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro
                 155                 160                 165

 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
                 170                 175                 180

 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu
                 185                 190                 195

 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
                 200                 205        

<210> 9
<211> 603
<212> DNA
<213> Homo sapiens

<400> 9
 atgtctcctg agcccgctct gtccccagcc ctgcagctgc tgctgtggca 50

 cagtgcactc tggacagtgc aggaagccac ccccctgggc cctgccagct 100

 ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 150

 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct 200

 gtgccacccc gaggagctgg tgctgctcgg acactctctg ggcatcccct 250

 gggctcccct gagcagctgc cccagccagg ccctgcagct ggcaggctgc 300

 ttgagccaac tccatagcgg ccttttcctc taccaggggc tcctgcaggc 350

 cctggaaggg atctcccccg agttgggtcc caccttggac acactgcagc 400

 tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 450

 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc 500

 ctctgctttc cagcgccggg caggaggggt cctggttgcc tcccatctgc 550

 agagcttcct ggaggtgtcg taccgcgttc tacgccacct tgcccagccc 600

 tga 603

<210> 10
<211> 200
<212> PRT
<213> Homo sapiens

<400> 10
 Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu
   1               5                  10                  15

 Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly
                  20                  25                  30

 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
                  35                  40                  45

 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys
                  50                  55                  60

 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu
                  65                  70                  75

 Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys
                  80                  85                  90

 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His
                  95                 100                 105

 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly
                 110                 115                 120

 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp
                 125                 130                 135

 Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu
                 140                 145                 150

 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala
                 155                 160                 165

 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala
                 170                 175                 180

 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg
                 185                 190                 195

 His Leu Ala Gln Pro
                 200

<210> 11
<211> 615
<212> DNA
<213> Homo sapiens

<400> 11
 atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct 50

 gctgctgtgg cacagtgcac tctggacagt gcaggaagcc acccccctgg 100

 gccctgccag ctccctgccc cagagcttcc tgctcaagtg cttagagcaa 150

 gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc 200

 cacctacaag ctgtgccacc ccgaggagct ggtgctgctc ggacactctc 250

 tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag 300

 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg 350

 gctcctgcag gccctggaag ggatctcccc cgagttgggt cccaccttgg 400

 acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 450

 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat 500

 gccggccttc gcctctgctt tccagcgccg ggcaggaggg gtcctggttg 550

 cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 600

 cttgcccagc  cctga 615

<210> 12
<211> 204
<212> PRT
<213> Homo sapiens

<400> 12
 Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu
   1               5                  10                  15

 Gln Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala
                  20                  25                  30

 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu
                  35                  40                  45

 Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala
                  50                  55                  60

 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu
                  65                  70                  75

 Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro
                  80                  85                  90

 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu
                  95                 100                 105

 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln
                 110                 115                 120

 Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr
                 125                 130                 135

 Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln
                 140                 145                 150

 Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly
                 155                 160                 165

 Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly
                 170                 175                 180

 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr
                 185                 190                 195

 Arg Val Leu Arg His Leu Ala Gln Pro
                 200                

<210> 13
<211> 516
<212> DNA
<213> Homo sapiens

<400> 13
 atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct 50

 gctgctgtgg cacagtgcac tctggacagt gcaggaagcc acccccctgg 100

 gccctgccag ctccctgccc cagagcttcc tgctcaagtg cttagagcaa 150

 gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctggtgag 200

 tgaggcaggc tgcttgagcc aactccatag cggccttttc ctctaccagg 250

 ggctcctgca ggccctggaa gggatctccc ccgagttggg tcccaccttg 300

 gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca 350

 gatggaagaa ctgggaatgg cccctgccct gcagcccacc cagggtgcca 400

 tgccggcctt cgcctctgct ttccagcgcc gggcaggagg ggtcctggtt 450

 gcctcccatc tgcagagctt cctggaggtg tcgtaccgcg ttctacgcca 500

 ccttgcccag  ccctga 516

<210> 14
<211> 171
<212> PRT
<213> Homo sapiens

<400> 14
 Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu
   1               5                  10                  15

 Gln Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala
                  20                  25                  30

 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu
                  35                  40                  45

 Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala
                  50                  55                  60

 Leu Gln Glu Lys Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu
                  65                  70                  75

 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu
                  80                  85                  90

 Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu
                  95                 100                 105

 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu
                 110                 115                 120

 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro
                 125                 130                 135

 Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val
                 140                 145                 150

 Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu
                 155                 160                 165

 Arg His Leu Ala Gln Pro
                 170    

<210> 15
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 15
 ccgcaaggaa  tcggtcaat 19

<210> 16
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 16
 gatcagcaat cgcgcatatg 20

<210> 17
<211> 17
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 17
 cactacatgg  cgtgatt 17

<210> 18
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 18
 Gly Ser Gly Ser Gly Ser
                   5    

<210> 19
<211> 4
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 19
 Gly Gly Gly Ser
                

