                               SEQUENCE LISTING	

<110> N.V. ORGANON
      MEDAREX, INC.
 
<120> FULLY HUMAN ANTIBODIES TO BTLA

<130> JB20097017

<140>
<141>

<150> 61/257,612
<151> 2009-11-03

<150> 61/230,332
<151> 2009-07-31

<160> 67    

<170> PatentIn version 3.5

<210> 1
<211> 870
<212> DNA
<213> Homo sapiens

<400> 1
atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt cttcttaatc       60

ccatatctgg acatctggaa catccatggg aaagaatcat gtgatgtaca gctttatata      120

aagagacaat ctgaacactc catcttagca ggagatccct ttgaactaga atgccctgtg      180

aaatactgtg ctaacaggcc tcatgtgact tggtgcaagc tcaatggaac aacatgtgta      240

aaacttgaag atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta      300

cattttgaac caatgcttcc taatgacaat gggtcatacc gctgttctgc aaattttcag      360

tctaatctca ttgaaagcca ctcaacaact ctttatgtga cagatgtaaa aggtgcctca      420

gaacgaccct ccaaggacga agtggcaagc agaccctggc tcctgtatag tttacttcct      480

ttggggggat tgcctctact catcactacc tggttctgcc tgttctgctg cctgagaagg      540

caccaaggaa agcaaaatga actctctgac acagcaggaa gggaaattaa tctggttgat      600

gctcacctta agagcgagca aacagaagca agcaccaggc aaaattccca agtactgcta      660

tcagaagctg gaatttatga taatgaccct gacctttgtt tcaggatgca ggaagggtct      720

gaagtttgtt ctaatccatg cctggaagaa aacaaaccag gcattgttta tgcttccctg      780

aaccattctg tcattggact gaactcaaga ctggcaagaa atgtaaaaga agcaccaaca      840

gaatatgcat ccatatgtgt gaggagttaa                                       870


<210> 2
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Met Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Gly Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Val Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Trp Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Ala Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Cys Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Leu Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210> 3
<211> 921
<212> DNA
<213> Mus musculus

<400> 3
atgaagacag tgcctgccat gcttgggact cctcggttat ttagggaatt cttcatcctc       60

catctgggcc tctggagcat cctttgtgag aaagctacta agaggaatga tgaagagtgt      120

gaagtgcaac ttaatattaa gaggaattcc aaacactctg cctggacagg agagttattt      180

aaaattgaat gtcctgtgaa atactgtgtt catagaccta atgtgacttg gtgtaagcac      240

aatggaacaa tctgggtacc ccttgaagtt ggtcctcagc tatacactag ttgggaagaa      300

aatcgatcag ttccggtttt tgttctccat tttaaaccaa tacatctcag tgataacggg      360

tcgtatagct gttctacaaa cttcaattct caagttatta atagccattc agtaaccatc      420

catgtgagag aaaggactca aaactcttca gaacacccac taataacagt atctgacatc      480

ccagatgcca ccaatgcctc aggaccatcc accatggaag agaggccagg caggacttgg      540

ctgctttaca ccttgcttcc tttgggggca ttgcttctgc tccttgcctg tgtctgcctg      600

ctctgctttc tgaaaaggat ccaagggaaa gaaaagaagc cttctgactt ggcaggaagg      660

gacactaacc tggttgatat tccagccagt tccaggacaa atcaccaagc actgccatca      720

ggaactggaa tttatgataa tgatccctgg tctagcatgc aggatgaatc tgaattgaca      780

attagcttgc aatcagagag aaacaaccag ggcattgttt atgcttcttt gaaccattgt      840

gttattggaa ggaatccaag acaggaaaac aacatgcagg aggcacccac agaatatgca      900

tccatttgtg tgagaagtta a                                                921


<210> 4
<211> 306
<212> PRT
<213> Mus musculus

<400> 4
Met Lys Thr Val Pro Ala Met Leu Gly Thr Pro Arg Leu Phe Arg Glu 
1               5                   10                  15      


Phe Phe Ile Leu His Leu Gly Leu Trp Ser Ile Leu Cys Glu Lys Ala 
            20                  25                  30          


Thr Lys Arg Asn Asp Glu Glu Cys Glu Val Gln Leu Asn Ile Lys Arg 
        35                  40                  45              


Asn Ser Lys His Ser Ala Trp Thr Gly Glu Leu Phe Lys Ile Glu Cys 
    50                  55                  60                  


Pro Val Lys Tyr Cys Val His Arg Pro Asn Val Thr Trp Cys Lys His 
65                  70                  75                  80  


Asn Gly Thr Ile Trp Val Pro Leu Glu Val Gly Pro Gln Leu Tyr Thr 
                85                  90                  95      


Ser Trp Glu Glu Asn Arg Ser Val Pro Val Phe Val Leu His Phe Lys 
            100                 105                 110         


Pro Ile His Leu Ser Asp Asn Gly Ser Tyr Ser Cys Ser Thr Asn Phe 
        115                 120                 125             


Asn Ser Gln Val Ile Asn Ser His Ser Val Thr Ile His Val Arg Glu 
    130                 135                 140                 


Arg Thr Gln Asn Ser Ser Glu His Pro Leu Ile Thr Val Ser Asp Ile 
145                 150                 155                 160 


Pro Asp Ala Thr Asn Ala Ser Gly Pro Ser Thr Met Glu Glu Arg Pro 
                165                 170                 175     


Gly Arg Thr Trp Leu Leu Tyr Thr Leu Leu Pro Leu Gly Ala Leu Leu 
            180                 185                 190         


Leu Leu Leu Ala Cys Val Cys Leu Leu Cys Phe Leu Lys Arg Ile Gln 
        195                 200                 205             


Gly Lys Glu Lys Lys Pro Ser Asp Leu Ala Gly Arg Asp Thr Asn Leu 
    210                 215                 220                 


Val Asp Ile Pro Ala Ser Ser Arg Thr Asn His Gln Ala Leu Pro Ser 
225                 230                 235                 240 


Gly Thr Gly Ile Tyr Asp Asn Asp Pro Trp Ser Ser Met Gln Asp Glu 
                245                 250                 255     


Ser Glu Leu Thr Ile Ser Leu Gln Ser Glu Arg Asn Asn Gln Gly Ile 
            260                 265                 270         


Val Tyr Ala Ser Leu Asn His Cys Val Ile Gly Arg Asn Pro Arg Gln 
        275                 280                 285             


Glu Asn Asn Met Gln Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
    290                 295                 300                 


Arg Ser 
305     


<210> 5
<211> 5
<212> PRT
<213> Homo sapiens

<400> 5
Ser Tyr Asp Met His 
1               5   


<210> 6
<211> 16
<212> PRT
<213> Homo sapiens

<400> 6
Val Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys Gly 
1               5                   10                  15      


<210> 7
<211> 13
<212> PRT
<213> Homo sapiens

<400> 7
Glu Gly Met Ala Ala His Asn Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210> 8
<211> 420
<212> DNA
<213> Homo sapiens

<400> 8
atggagttgg ggctgagctg ggttttcctt gttgctatat tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtacagccgg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac catcagtagt tacgacatgc actgggtccg ccaagcaaca      180

ggaaaaggtc tggagtgggt ctcagttatt ggtcctgctg gtgacacata ctatccaggc      240

tccgtgaagg gccgattcac catctccaga gaaaatgcca agaactcctt gtatcttcaa      300

atgaacagcc tgagagccgg ggacacggct gtgtattact gtgcaagaga ggggatggct      360

gcccacaact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      420


<210> 9
<211> 140
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile 
        35                  40                  45              


Ser Ser Tyr Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Val Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Pro Gly 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Met Ala Ala His Asn Tyr Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140 


<210> 10
<211> 363
<212> DNA
<213> Homo sapiens

<400> 10
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccatcagt agttacgaca tgcactgggt ccgccaagca      120

acaggaaaag gtctggagtg ggtctcagtt attggtcctg ctggtgacac atactatcca      180

ggctccgtga agggccgatt caccatctcc agagaaaatg ccaagaactc cttgtatctt      240

caaatgaaca gcctgagagc cggggacacg gctgtgtatt actgtgcaag agaggggatg      300

gctgcccaca actactacgg tatggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 11
<211> 121
<212> PRT
<213> Homo sapiens

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Met Ala Ala His Asn Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 12
<211> 11
<212> PRT
<213> Homo sapiens

<400> 12
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 13
<211> 7
<212> PRT
<213> Homo sapiens

<400> 13
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 14
<211> 10
<212> PRT
<213> Homo sapiens

<400> 14
Gln Gln Arg Ser Asn Trp Pro Pro Ile Thr 
1               5                   10  


<210> 15
<211> 384
<212> DNA
<213> Homo sapiens

<400> 15
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      180

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      300

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcccccgat caccttcggc      360

caagggacac gactggagat taaa                                             384


<210> 16
<211> 128
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
        115                 120                 125             


<210> 17
<211> 324
<212> DNA
<213> Homo sapiens

<400> 17
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcccccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 18
<211> 108
<212> PRT
<213> Homo sapiens

<400> 18
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 19
<211> 5
<212> PRT
<213> Homo sapiens

<400> 19
His Tyr Tyr Trp Ser 
1               5   


<210> 20
<211> 16
<212> PRT
<213> Homo sapiens

<400> 20
Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 21
<211> 11
<212> PRT
<213> Homo sapiens

<400> 21
Glu Trp Pro Tyr Tyr Tyr Tyr Glu Met Asp Val 
1               5                   10      


<210> 22
<211> 414
<212> DNA
<213> Homo sapiens

<400> 22
atgaaacatc tgtggttctt ccttctcctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct atccctcacc      120

tgcactgtcc atggtggctc catcaatcat tactactgga gctggatccg gcagccccca      180

gggaagggac tggaatggat tggatatatc tattacagtg ggagcaccaa gtacaatccc      240

tccctcaaga gtcgcgtcag catatcagta gacacgtcca agaaccagtt ctccctgaag      300

ctgacctctg tgaccgctgc ggacacggcc gtgtattatt gtgcgagaga gtggccctac      360

tattactacg aaatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca            414


<210> 23
<211> 138
<212> PRT
<213> Homo sapiens

<400> 23
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val His Gly Gly Ser Ile 
        35                  40                  45              


Asn His Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Trp Pro Tyr Tyr Tyr Tyr Glu Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135             


<210> 24
<211> 357
<212> DNA
<213> Homo sapiens

<400> 24
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctatccctc       60

acctgcactg tccatggtgg ctccatcaat cattactact ggagctggat ccggcagccc      120

ccagggaagg gactggaatg gattggatat atctattaca gtgggagcac caagtacaat      180

ccctccctca agagtcgcgt cagcatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgacct ctgtgaccgc tgcggacacg gccgtgtatt attgtgcgag agagtggccc      300

tactattact acgaaatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210> 25
<211> 119
<212> PRT
<213> Homo sapiens

<400> 25
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val His Gly Gly Ser Ile Asn His Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Trp Pro Tyr Tyr Tyr Tyr Glu Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 26
<211> 12
<212> PRT
<213> Homo sapiens

<400> 26
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 27
<211> 7
<212> PRT
<213> Homo sapiens

<400> 27
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 28
<211> 9
<212> PRT
<213> Homo sapiens

<400> 28
Gln Gln Tyr Gly Ser Ser Phe Arg Thr 
1               5                   


<210> 29
<211> 384
<212> DNA
<213> Homo sapiens

<400> 29
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gttcatttcg gacgttcggc      360

caagggacca aggtggaaat caaa                                             384


<210> 30
<211> 128
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Phe Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210> 31
<211> 324
<212> DNA
<213> Homo sapiens

<400> 31
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gttcatttcg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 32
<211> 108
<212> PRT
<213> Homo sapiens

<400> 32
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 33
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 33
gcctgagttc cacgacaccg tc                                                22


<210> 34
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 34
gcaggcacac aacagaggca gttccagatt tc                                     32


<210> 35
<211> 289
<212> PRT
<213> Homo sapiens

<400> 35
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Leu Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210> 36
<211> 870
<212> DNA
<213> Homo sapiens

<400> 36
atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt cttcttaatc       60

ccatatctgg acatctggaa catccatggg aaagaatcat gtgatgtaca gctttatata      120

aagagacaat ctgaacactc catcttagca ggagatccct ttgaactaga atgccctgtg      180

aaatactgtg ctaacaggcc tcatgtgact tggtgcaagc tcaatggaac aacatgtgta      240

aaacttgaag atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta      300

cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc aaattttcag      360

tctaatctca ttgaaagcca ctcaacaact ctttatgtga cagatgtaaa aagtgcctca      420

gaacgaccct ccaaggacga aatggcaagc agaccctggc tcctgtatag tttacttcct      480

ttggggggat tgcctctact catcactacc tgtttctgcc tgttctgctg cctgagaagg      540

caccaaggaa agcaaaatga actctctgac acagcaggaa gggaaattaa cctggttgat      600

gctcacctta agagtgagca aacagaagca agcaccaggc aaaattccca agtactgcta      660

tcagaaactg gaatttatga taatgaccct gacctttgtt tcaggatgca ggaagggtct      720

gaagtttatt ctaatccatg cctggaagaa aacaaaccag gcattgttta tgcttccctg      780

aaccattctg tcattggact gaactcaaga ctggcaagaa atgtaaaaga agcaccaaca      840

gaatatgcat ccatatgtgt gaggagttaa                                       870


<210> 37
<211> 289
<212> PRT
<213> Homo sapiens

<400> 37
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Lys" or "Leu" or "Ala" or "Phe"

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<400> 38
Ser Tyr Asp Met His 
1               5   


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Lys" or "Leu" or "Ala" or "Phe"

<220>
<221> misc_feature
<222> (3)..(3)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Gln" or "Ala"

<220>
<221> misc_feature
<222> (7)..(7)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="Lys" or "Leu" or "Ala" or "Phe"

<220>
<221> misc_feature
<222> (11)..(11)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<400> 39
Glu Gly Met Ala Ala His Asn Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (4)..(4)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<400> 40
Asp Ala Ser Gln Arg Ala Thr 
1               5           


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (5)..(5)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<400> 41
Gln Gln Arg Ser Gln Trp Pro Pro Ile Thr 
1               5                   10  


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="Gln" or "Ala"

<220>
<221> misc_feature
<222> (11)..(11)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (12)..(12)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<400> 42
Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="Lys" or "Leu" or "Ala" or "Phe"

<220>
<221> misc_feature
<222> (9)..(9)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotations for said position"

<400> 43
Glu Trp Pro Tyr Tyr Tyr Tyr Glu Met Asp Val 
1               5                   10      


<210> 44
<211> 441
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 44
atggacatac tttgttccac gctcctgcta ctgactgtcc cgtcctgggt cttatcccag       60

gtcaccttga gggagtctgg tcctgcgctg gtgaaaccca cacagaccct cacactgacc      120

tgcaccttct ctgggttctc actcagcact agtggaatgg gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca gtcattgatt gggatggtac taaagactac      240

agcacatctc tgaagaccag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggatccgt      360

attaatgtgg ttcggggagt tattatcaac tactatggta tggacgtctg gggccaaggg      420

accacggtca ccgtctcctc a                                                441


<210> 45
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Asp Ile Leu Cys Ser Thr Leu Leu Leu Leu Thr Val Pro Ser Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys 
            20                  25                  30          


Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Asp Trp Asp Gly Thr Lys Asp Tyr 
65                  70                  75                  80  


Ser Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Arg Ile Asn Val Val Arg Gly Val Ile 
        115                 120                 125             


Ile Asn Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser 
145         


<210> 46
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 46
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta ggtcacccgc gtacactttt      360

ggccagggga ccaagctgga gatcaaa                                          387


<210> 47
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Arg Ser Pro Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys 
    


<210> 48
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 48
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      180

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      300

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccattcac tttcggccct      360

gggaccaaag tggatatcaa a                                                381


<210> 49
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125         


<210> 50
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat gatgcatcca acagggccac tggcatccca      240

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctagag      300

cctgaagatt ttgcagttta ttactgtcag cagcgtagca actggccatt cactttcggc      360

cctgggacca aagtggatat caaa                                             384


<210> 51
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Asn Trp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125             


<210> 52
<211> 432
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
atggagtttg tgctgagctg ggttttcctt gttgctatat taaaaggtgt ccagtgtgag       60

gttcagctgg tgcagtctgg gggaggcttg gtacatcctg gggggtccct gagactctcc      120

tgtgcaggct ctggattcac cttcagtagc tatgctatgc actgggttcg ccaggctcca      180

ggaaaaggtc tggagtgggt ttcagttatt ggtactggtg ttgccacata ctatgcagac      240

tccgtgaagg gccgattcac catctccaga gacaatgcca agaactcctt gtttcttcat      300

atgaacagcc tgagagccga ggacatggct gtgtattact gtgcaagagg cttttactat      360

ggttcgggga ctaattatta caaccgcggt atggacgtct ggggccaagg gaccacggtc      420

accgtctcct ca                                                          432


<210> 53
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Glu Phe Val Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Val Ile Gly Thr Gly Val Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Phe Leu His Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Phe Tyr Tyr Gly Ser Gly Thr Asn Tyr Tyr Asn 
        115                 120                 125             


Arg Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


<210> 54
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgta cacttttggc      360

caggggacca agctggagat caaa                                             384


<210> 55
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210> 56
<211> 441
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
atggacatac tttgttccac gctcctgcta ctgactgtcc cgtcctgggt cttatcccag       60

gtcaccttga gggagtctgg tcctgcgctg gtgaaaccca cacagaccct cacactgacc      120

tgcaccttct ctggggtctc actcagcact agtggaatgt gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca gtcattgatt gggatgatga taaatactac      240

aacacatctc tgaagaccag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggctacgt      360

attactgtgg ttcggggagt tattataacc tactacggtc tggacgtctg gggccaaggg      420

accacggtca ccgtctcctc a                                                441


<210> 57
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Asp Ile Leu Cys Ser Thr Leu Leu Leu Leu Thr Val Pro Ser Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys 
            20                  25                  30          


Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Asp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Leu Arg Ile Thr Val Val Arg Gly Val Ile 
        115                 120                 125             


Ile Thr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser 
145         


<210> 58
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta ggtcactcac tttcggccct      360

gggaccaaag tggatatcaa a                                                381


<210> 59
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Arg Ser Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125         


<210> 60
<211> 432
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 60
atggagtttg tgctgagctg ggttttcctt gttgctatat taaaaggtgt ccagtgtgag       60

gttcagctgg tgcagtctgg gggaggcttg gtacatcctg gggggtccct gagactctcc      120

tgtgcaggct ctggattcac cttcagtagc tatgctatgc actgggttcg ccaggctcca      180

ggaaaaggtc tggagtgggt atcagttatt ggtcctggtg gtggcacata ctatgcagac      240

tccgtgaagg gccgattcac catctccaga gacaatgcca agaactcctt gtatcttcaa      300

atgaacagcc tgagagccga ggacatggct gtgtatttct gtgcaagagg ctattactat      360

ggttcgggga atttttttaa gaattacggt atggacgtct ggggccaagg gaccacggtc      420

accgtctcct ca                                                          432


<210> 61
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Met Glu Phe Val Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Val Ile Gly Pro Gly Gly Gly Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Gly Tyr Tyr Tyr Gly Ser Gly Asn Phe Phe Lys Asn 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


<210> 62
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 62
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gccgggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcaccgta cacttttggc      360

caggggacca agctgcagat caaa                                             384


<210> 63
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Gly Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Lys 
        115                 120                 125             


<210> 64
<211> 438
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 64
atggagtttg ggctgaactg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgaagcgt ctggattcac cttcaataac tatgacatga actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggaatgatg gaagtaataa atactttgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agaggttttt      360

actatggttc ggggaattat tataacctac tacggtatgg acgtctgggg ccaagggacc      420

acggtcaccg tctcctca                                                    438


<210> 65
<211> 146
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Met Glu Phe Gly Leu Asn Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Asn Tyr Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Phe Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Phe Thr Met Val Arg Gly Ile Ile Ile 
        115                 120                 125             


Thr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210> 66
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 66
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtt tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta ggtcaatcat caccttcggc      360

caagggacac gactggagat taaa                                             384


<210> 67
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Phe Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Arg Ser Ile Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
        115                 120                 125             


