
                                SEQUENCE LISTING

<110> XCELLEREX, INC.
      LEE, Cynthia K.
      MONATH, Thomas P.
      GUERTIN, Patrick M.
      HAYMAN, Edward G.

<120> High Yield Yellow Fever Virus Strain
  with Increased Propagation in Cells
  

<130> 4098.3000 WO

<140> PCT/US2010/043010   
<141> 2010-07-23  

<150> US 61/230,483       
<151> 2009-07-31  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 6300
<212> DNA
<213> Coquillettidia fuscopennata

<400> 1
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggttcgtga ggaacccctt ttttgcagtg acggctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatagac ctgctgaggt 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ctaccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gtcgagttca ttgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa acagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttact ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttctt gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaata tgcactgaca aaatgttttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgtcaaa aggagccccc tgcaggattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg agaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgtggaacgc ctggccgtca tgggagacac 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtacttatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagcttgc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccatttttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaagtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa gttattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtagtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggcg tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccgcaa tgttcttttg 4020
tgccgtggtt atcatagggg tccttcacca gaatttcaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggact cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcgggagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccctccat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca tcgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccagttgatc gcggctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctgtccttga 5160
ttttcatcct ggagctggga agacaagacg tttcctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ctatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat tatggatgaa gcccattttt tggatccagc 5460
tagcatagcc gctagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgtatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cctacaagtg aaaataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300




<210> 2
<211> 6300
<212> DNA
<213> Coquillettidia fuscopennata

<400> 2
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac gaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggttcgtga ggaacccctt ttttgcagtg acggctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatagac ctgctgaggt 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ctaccgacat 1440
taagactctc aggtttgatg ccctgtcagg ctcccaggaa gtcgagttca ttgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa acagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttact ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttctt gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaata tgcactgaca aaatgttttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgtcaaa aggagccccc tgcaggattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg agaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgtggaacgc ctggccgtca tgggagacac 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtacttatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagcttgc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccatttttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaagtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa gttattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtagtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggcg tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccgcaa tgttcttttg 4020
tgccgtggtt atcatagggg tccttcacca gaatttcaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggact cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcgggagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccctccat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca tcgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccagttgatc gcggctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctgtccttga 5160
ttttcatcct ggagctggga agacaagacg tttcctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ctatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat tatggatgaa gcccattttt tggatccagc 5460
tagcatagcc gctagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgtatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cctacaagtg aaaataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300




<210> 3
<211> 3412
<212> PRT
<213> Coquillettidia fuscopennata

<400> 3
Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val
 1               5                  10                  15      
Arg Arg Gly Val Arg Ser Leu Ser Asn Lys Ile Lys Gln Lys Thr Lys
            20                  25                  30          
Gln Ile Gly Asn Arg Pro Gly Pro Ser Arg Gly Val Gln Gly Phe Ile
        35                  40                  45              
Phe Phe Phe Leu Phe Asn Ile Leu Thr Gly Lys Lys Ile Thr Ala His
    50                  55                  60                  
Leu Lys Arg Leu Trp Lys Met Leu Asp Pro Arg Gln Gly Leu Ala Val
65                  70                  75                  80  
Leu Arg Lys Val Lys Arg Val Val Ala Ser Leu Met Arg Gly Leu Ser
                85                  90                  95      
Ser Arg Lys Arg Arg Ser His Asp Val Leu Thr Val Gln Phe Leu Ile
            100                 105                 110         
Leu Gly Met Leu Leu Met Thr Gly Gly Val Thr Leu Val Arg Lys Asn
        115                 120                 125             
Arg Trp Leu Leu Leu Asn Val Thr Ser Glu Asp Leu Gly Lys Thr Phe
    130                 135                 140                 
Ser Val Gly Thr Gly Asn Cys Thr Thr Asn Ile Leu Glu Ala Lys Tyr
145                 150                 155                 160 
Trp Cys Pro Asp Ser Met Glu Tyr Asn Cys Pro Asn Leu Ser Pro Arg
                165                 170                 175     
Glu Glu Pro Asp Asp Ile Asp Cys Trp Cys Tyr Gly Val Glu Asn Val
            180                 185                 190         
Arg Val Ala Tyr Gly Lys Cys Asp Ser Ala Gly Arg Ser Arg Arg Ser
        195                 200                 205             
Arg Arg Ala Ile Asp Leu Pro Thr His Glu Asn His Gly Leu Lys Thr
    210                 215                 220                 
Arg Gln Glu Lys Trp Met Thr Gly Arg Met Gly Glu Arg Gln Leu Gln
225                 230                 235                 240 
Lys Ile Glu Arg Trp Phe Val Arg Asn Pro Phe Phe Ala Val Thr Ala
                245                 250                 255     
Leu Thr Ile Ala Tyr Leu Val Gly Ser Asn Met Thr Gln Arg Val Val
            260                 265                 270         
Ile Ala Leu Leu Val Leu Ala Val Gly Pro Ala Tyr Ser Ala His Cys
        275                 280                 285             
Ile Gly Ile Thr Asp Arg Asp Phe Ile Glu Gly Val His Gly Gly Thr
    290                 295                 300                 
Trp Val Ser Ala Thr Leu Glu Gln Asp Lys Cys Val Thr Val Met Ala
305                 310                 315                 320 
Pro Asp Lys Pro Ser Leu Asp Ile Ser Leu Glu Thr Val Ala Ile Asp
                325                 330                 335     
Arg Pro Ala Glu Val Arg Lys Val Cys Tyr Asn Ala Val Leu Thr His
            340                 345                 350         
Val Lys Ile Asn Asp Lys Cys Pro Ser Thr Gly Glu Ala His Leu Ala
        355                 360                 365             
Glu Glu Asn Glu Gly Asp Asn Ala Cys Lys Arg Thr Tyr Ser Asp Arg
    370                 375                 380                 
Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Val Ala
385                 390                 395                 400 
Cys Ala Lys Phe Thr Cys Ala Lys Ser Met Ser Leu Phe Glu Val Asp
                405                 410                 415     
Gln Thr Lys Ile Gln Tyr Val Ile Arg Ala Gln Leu His Val Gly Ala
            420                 425                 430         
Lys Gln Glu Asn Trp Thr Thr Asp Ile Lys Thr Leu Lys Phe Asp Ala
        435                 440                 445             
Leu Ser Gly Ser Gln Glu Val Glu Phe Ile Gly Tyr Gly Lys Ala Thr
    450                 455                 460                 
Leu Glu Cys Gln Val Gln Thr Ala Val Asp Phe Gly Asn Ser Tyr Ile
465                 470                 475                 480 
Ala Glu Met Glu Thr Glu Ser Trp Ile Val Asp Arg Gln Trp Ala Gln
                485                 490                 495     
Asp Leu Thr Leu Pro Trp Gln Ser Gly Ser Gly Gly Val Trp Arg Glu
            500                 505                 510         
Met His His Leu Val Glu Phe Glu Pro Pro His Ala Ala Thr Ile Arg
        515                 520                 525             
Val Leu Ala Leu Gly Asn Gln Glu Gly Ser Leu Lys Thr Ala Leu Thr
    530                 535                 540                 
Gly Ala Met Arg Val Thr Lys Asp Thr Asn Asp Asn Asn Leu Tyr Lys
545                 550                 555                 560 
Leu His Gly Gly His Val Ser Cys Arg Val Lys Leu Ser Ala Leu Thr
                565                 570                 575     
Leu Lys Gly Thr Ser Tyr Lys Ile Cys Thr Asp Lys Met Phe Phe Val
            580                 585                 590         
Lys Asn Pro Thr Asp Thr Gly His Gly Thr Val Val Met Gln Val Lys
        595                 600                 605             
Val Ser Lys Gly Ala Pro Cys Arg Ile Pro Val Ile Val Ala Asp Asp
    610                 615                 620                 
Leu Thr Ala Ala Ile Asn Lys Gly Ile Leu Val Thr Val Asn Pro Ile
625                 630                 635                 640 
Ala Ser Thr Asn Asp Asp Glu Val Leu Ile Glu Val Asn Pro Pro Phe
                645                 650                 655     
Gly Asp Ser Tyr Ile Ile Val Gly Arg Gly Asp Ser Arg Leu Thr Tyr
            660                 665                 670         
Gln Trp His Lys Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln Thr
        675                 680                 685             
Met Lys Gly Val Glu Arg Leu Ala Val Met Gly Asp Thr Ala Trp Asp
    690                 695                 700                 
Phe Ser Ser Ala Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile His
705                 710                 715                 720 
Thr Val Phe Gly Ser Ala Phe Gln Gly Leu Phe Gly Gly Leu Asn Trp
                725                 730                 735     
Ile Thr Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn
            740                 745                 750         
Thr Arg Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile
        755                 760                 765             
Met Met Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile
    770                 775                 780                 
Asn Phe Gly Lys Arg Glu Leu Lys Cys Gly Asp Gly Ile Phe Ile Phe
785                 790                 795                 800 
Arg Asp Ser Asp Asp Trp Leu Asn Lys Tyr Ser Tyr Tyr Pro Glu Asp
                805                 810                 815     
Pro Val Lys Leu Ala Ser Ile Val Lys Ala Ser Phe Glu Glu Gly Lys
            820                 825                 830         
Cys Gly Leu Asn Ser Val Asp Ser Leu Glu His Glu Met Trp Arg Ser
        835                 840                 845             
Arg Ala Asp Glu Ile Asn Ala Ile Phe Glu Glu Asn Glu Val Asp Ile
    850                 855                 860                 
Ser Val Val Val Gln Asp Pro Lys Asn Val Tyr Gln Arg Gly Thr His
865                 870                 875                 880 
Pro Phe Ser Arg Ile Arg Asp Gly Leu Gln Tyr Gly Trp Lys Thr Trp
                885                 890                 895     
Gly Lys Asn Leu Val Phe Ser Pro Gly Arg Lys Asn Gly Ser Phe Ile
            900                 905                 910         
Ile Asp Gly Lys Ser Arg Lys Glu Cys Pro Phe Ser Asn Arg Val Trp
        915                 920                 925             
Asn Ser Phe Gln Ile Glu Glu Phe Gly Thr Gly Val Phe Thr Thr Arg
    930                 935                 940                 
Val Tyr Met Asp Ala Val Phe Glu Tyr Thr Ile Asp Cys Asp Gly Ser
945                 950                 955                 960 
Ile Leu Gly Ala Ala Val Asn Gly Lys Lys Ser Ala His Gly Ser Pro
                965                 970                 975     
Thr Phe Trp Met Gly Ser His Glu Val Asn Gly Thr Trp Met Ile His
            980                 985                 990         
Thr Leu Glu Ala Leu Asp Tyr Lys Glu Cys Glu Trp Pro Leu Thr His
        995                 1000                1005            
Thr Ile Gly Thr Ser Val Glu Glu Ser Glu Met Phe Met Pro Arg Ser
    1010                1015                1020                
Ile Gly Gly Pro Val Ser Ser His Asn His Ile Pro Gly Tyr Lys Val
1025                1030                1035                1040
Gln Thr Asn Gly Pro Trp Met Gln Val Pro Leu Glu Val Lys Arg Glu
                1045                1050                1055    
Ala Cys Pro Gly Thr Ser Val Ile Ile Asp Gly Asn Cys Asp Gly Arg
            1060                1065                1070        
Gly Lys Ser Thr Arg Ser Thr Thr Asp Ser Gly Lys Val Ile Pro Glu
        1075                1080                1085            
Trp Cys Cys Arg Ser Cys Thr Met Pro Pro Val Ser Phe His Gly Ser
    1090                1095                1100                
Asp Gly Cys Trp Tyr Pro Met Glu Ile Arg Pro Arg Lys Thr His Glu
1105                1110                1115                1120
Ser His Leu Val Arg Ser Trp Val Thr Ala Gly Glu Ile His Ala Val
                1125                1130                1135    
Pro Phe Gly Leu Val Ser Met Met Ile Ala Met Glu Val Val Leu Arg
            1140                1145                1150        
Lys Arg Gln Gly Pro Lys Gln Met Leu Val Gly Gly Val Val Leu Leu
        1155                1160                1165            
Gly Ala Met Leu Val Gly Gln Val Thr Leu Leu Asp Leu Leu Lys Leu
    1170                1175                1180                
Thr Val Ala Val Gly Leu His Phe His Glu Met Asn Asn Gly Gly Asp
1185                1190                1195                1200
Ala Met Tyr Met Ala Leu Ile Ala Ala Phe Ser Ile Arg Pro Gly Leu
                1205                1210                1215    
Leu Ile Gly Phe Gly Leu Arg Thr Leu Trp Ser Pro Arg Glu Arg Leu
            1220                1225                1230        
Val Leu Thr Leu Gly Ala Ala Met Val Glu Ile Ala Leu Gly Gly Val
        1235                1240                1245            
Met Gly Gly Leu Trp Lys Tyr Leu Asn Ala Val Ser Leu Cys Ile Leu
    1250                1255                1260                
Thr Ile Asn Ala Val Ala Ser Arg Lys Ala Ser Asn Thr Ile Leu Pro
1265                1270                1275                1280
Leu Met Ala Leu Leu Thr Pro Val Thr Met Ala Glu Val Arg Leu Ala
                1285                1290                1295    
Ala Met Phe Phe Cys Ala Val Val Ile Ile Gly Val Leu His Gln Asn
            1300                1305                1310        
Phe Lys Asp Thr Ser Met Gln Lys Thr Ile Pro Leu Val Ala Leu Thr
        1315                1320                1325            
Leu Thr Ser Tyr Leu Gly Leu Thr Gln Pro Phe Leu Gly Leu Cys Ala
    1330                1335                1340                
Phe Leu Ala Thr Arg Ile Phe Gly Arg Arg Ser Ile Pro Val Asn Glu
1345                1350                1355                1360
Ala Leu Ala Ala Ala Gly Leu Val Gly Val Leu Ala Gly Leu Ala Phe
                1365                1370                1375    
Gln Glu Met Glu Asn Phe Leu Gly Pro Ile Ala Val Gly Gly Leu Leu
            1380                1385                1390        
Met Met Leu Val Ser Val Ala Gly Arg Val Asp Gly Leu Glu Leu Lys
        1395                1400                1405            
Lys Leu Gly Glu Val Ser Trp Glu Glu Glu Ala Glu Ile Ser Gly Ser
    1410                1415                1420                
Ser Ala Arg Tyr Asp Val Ala Leu Ser Glu Gln Gly Glu Phe Lys Leu
1425                1430                1435                1440
Leu Ser Glu Glu Lys Val Pro Trp Asp Gln Val Val Met Thr Ser Leu
                1445                1450                1455    
Ala Leu Val Gly Ala Ala Leu His Pro Phe Ala Leu Leu Leu Val Leu
            1460                1465                1470        
Ala Gly Trp Leu Phe His Val Arg Gly Ala Arg Arg Ser Gly Asp Val
        1475                1480                1485            
Leu Trp Asp Ile Pro Thr Pro Lys Ile Ile Glu Glu Cys Glu His Leu
    1490                1495                1500                
Glu Asp Gly Ile Tyr Gly Ile Phe Gln Ser Thr Phe Leu Gly Ala Ser
1505                1510                1515                1520
Gln Arg Gly Val Gly Val Ala Gln Gly Gly Val Phe His Thr Met Trp
                1525                1530                1535    
His Val Thr Arg Gly Ala Phe Leu Val Arg Asn Gly Lys Lys Leu Ile
            1540                1545                1550        
Pro Ser Trp Ala Ser Val Lys Glu Asp Leu Val Ala Tyr Gly Gly Ser
        1555                1560                1565            
Trp Lys Leu Glu Gly Arg Trp Asp Gly Glu Glu Glu Val Gln Leu Ile
    1570                1575                1580                
Ala Ala Val Pro Gly Lys Asn Val Val Asn Val Gln Thr Lys Pro Ser
1585                1590                1595                1600
Leu Phe Lys Val Arg Asn Gly Gly Glu Ile Gly Ala Val Ala Leu Asp
                1605                1610                1615    
Tyr Pro Ser Gly Thr Ser Gly Ser Pro Ile Val Asn Arg Asn Gly Glu
            1620                1625                1630        
Val Ile Gly Leu Tyr Gly Asn Gly Ile Leu Val Gly Asp Asn Ser Phe
        1635                1640                1645            
Val Ser Ala Ile Ser Gln Thr Glu Val Lys Glu Glu Gly Lys Glu Glu
    1650                1655                1660                
Leu Gln Glu Ile Pro Thr Met Leu Lys Lys Gly Met Thr Thr Val Leu
1665                1670                1675                1680
Asp Phe His Pro Gly Ala Gly Lys Thr Arg Arg Phe Leu Pro Gln Ile
                1685                1690                1695    
Leu Ala Glu Cys Ala Arg Arg Arg Leu Arg Thr Leu Val Leu Ala Pro
            1700                1705                1710        
Thr Arg Val Val Leu Ser Glu Met Lys Glu Ala Phe His Gly Leu Asp
        1715                1720                1725            
Val Lys Phe His Thr Gln Ala Phe Ser Ala His Gly Ser Gly Arg Glu
    1730                1735                1740                
Val Ile Asp Ala Met Cys His Ala Thr Leu Thr Tyr Arg Met Leu Glu
1745                1750                1755                1760
Pro Thr Arg Val Val Asn Trp Glu Val Ile Ile Met Asp Glu Ala His
                1765                1770                1775    
Phe Leu Asp Pro Ala Ser Ile Ala Ala Arg Gly Trp Ala Ala His Arg
            1780                1785                1790        
Ala Arg Ala Asn Glu Ser Ala Thr Ile Leu Met Thr Ala Thr Pro Pro
        1795                1800                1805            
Gly Thr Ser Asp Glu Phe Pro His Ser Asn Gly Glu Ile Glu Asp Val
    1810                1815                1820                
Gln Thr Asp Ile Pro Ser Glu Pro Trp Asn Thr Gly His Asp Trp Ile
1825                1830                1835                1840
Leu Ala Asp Lys Arg Pro Thr Ala Trp Phe Leu Pro Ser Ile Arg Ala
                1845                1850                1855    
Ala Asn Val Met Ala Ala Ser Leu Arg Lys Ala Gly Lys Ser Val Val
            1860                1865                1870        
Val Leu Asn Arg Lys Thr Phe Glu Arg Glu Tyr Pro Thr Ile Lys Gln
        1875                1880                1885            
Lys Lys Pro Asp Phe Ile Leu Ala Thr Asp Ile Ala Glu Met Gly Ala
    1890                1895                1900                
Asn Leu Cys Val Glu Arg Val Leu Asp Cys Arg Thr Ala Phe Lys Pro
1905                1910                1915                1920
Val Leu Val Asp Glu Gly Arg Lys Val Ala Ile Lys Gly Pro Leu Arg
                1925                1930                1935    
Ile Ser Ala Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn
            1940                1945                1950        
Pro Asn Arg Asp Gly Asp Ser Tyr Tyr Tyr Ser Glu Pro Thr Ser Glu
        1955                1960                1965            
Asn Asn Ala His His Val Cys Trp Leu Glu Ala Ser Met Leu Leu Asp
    1970                1975                1980                
Asn Met Glu Val Arg Gly Gly Met Val Ala Pro Leu Tyr Gly Val Glu
1985                1990                1995                2000
Gly Thr Lys Thr Pro Val Ser Pro Gly Glu Met Arg Leu Arg Asp Asp
                2005                2010                2015    
Gln Arg Lys Val Phe Arg Glu Leu Val Arg Asn Cys Asp Leu Pro Val
            2020                2025                2030        
Trp Leu Ser Trp Gln Val Ala Lys Ala Gly Leu Lys Thr Asn Asp Arg
        2035                2040                2045            
Lys Trp Cys Phe Glu Gly Pro Glu Glu His Glu Ile Leu Asn Asp Ser
    2050                2055                2060                
Gly Glu Thr Val Lys Cys Arg Ala Pro Gly Gly Ala Lys Lys Pro Leu
2065                2070                2075                2080
Arg Pro Arg Trp Cys Asp Glu Arg Val Ser Ser Asp Gln Ser Ala Leu
                2085                2090                2095    
Ser Glu Phe Ile Lys Phe Ala Glu Gly Arg Arg Gly Ala Ala Glu Val
            2100                2105                2110        
Leu Val Val Leu Ser Glu Leu Pro Asp Phe Leu Ala Lys Lys Gly Gly
        2115                2120                2125            
Glu Ala Met Asp Thr Ile Ser Val Phe Leu His Ser Glu Glu Gly Ser
    2130                2135                2140                
Arg Ala Tyr Arg Asn Ala Leu Ser Met Met Pro Glu Ala Met Thr Ile
2145                2150                2155                2160
Val Met Leu Phe Ile Leu Ala Gly Leu Leu Thr Ser Gly Met Val Ile
                2165                2170                2175    
Phe Phe Met Ser Pro Lys Gly Ile Ser Arg Met Ser Met Ala Met Gly
            2180                2185                2190        
Thr Met Ala Gly Cys Gly Tyr Leu Met Phe Leu Gly Gly Val Lys Pro
        2195                2200                2205            
Thr His Ile Ser Tyr Ile Met Leu Ile Phe Phe Val Leu Met Val Val
    2210                2215                2220                
Val Ile Pro Glu Pro Gly Gln Gln Arg Ser Ile Gln Asp Asn Gln Val
2225                2230                2235                2240
Ala Tyr Leu Ile Ile Gly Ile Leu Thr Leu Val Ser Ala Val Ala Ala
                2245                2250                2255    
Asn Glu Leu Gly Met Leu Glu Lys Thr Lys Glu Asp Leu Phe Gly Lys
            2260                2265                2270        
Lys Asn Leu Ile Pro Ser Ser Ala Ser Pro Trp Ser Trp Pro Asp Leu
        2275                2280                2285            
Asp Leu Lys Pro Gly Ala Ala Trp Thr Val Tyr Val Gly Ile Val Thr
    2290                2295                2300                
Met Leu Ser Pro Met Leu His His Trp Ile Lys Val Glu Tyr Gly Asn
2305                2310                2315                2320
Leu Ser Leu Ser Gly Ile Ala Gln Ser Ala Ser Val Leu Ser Phe Met
                2325                2330                2335    
Asp Lys Gly Ile Pro Phe Met Lys Met Asn Ile Ser Val Ile Met Leu
            2340                2345                2350        
Leu Val Ser Gly Trp Asn Ser Ile Thr Val Met Pro Leu Leu Cys Gly
        2355                2360                2365            
Ile Gly Cys Ala Met Leu His Trp Ser Leu Ile Leu Pro Gly Ile Lys
    2370                2375                2380                
Ala Gln Gln Ser Lys Leu Ala Gln Arg Arg Val Phe His Gly Val Ala
2385                2390                2395                2400
Lys Asn Pro Val Val Asp Gly Asn Pro Thr Val Asp Ile Glu Glu Ala
                2405                2410                2415    
Pro Glu Met Pro Ala Leu Tyr Glu Lys Lys Leu Ala Leu Tyr Leu Leu
            2420                2425                2430        
Leu Ala Leu Ser Leu Ala Ser Val Ala Met Cys Arg Thr Pro Phe Ser
        2435                2440                2445            
Leu Ala Glu Gly Ile Val Leu Ala Ser Ala Ala Leu Gly Pro Leu Ile
    2450                2455                2460                
Glu Gly Asn Thr Ser Leu Leu Trp Asn Gly Pro Met Ala Val Ser Met
2465                2470                2475                2480
Thr Gly Val Met Arg Gly Asn His Tyr Ala Phe Val Gly Val Met Tyr
                2485                2490                2495    
Asn Leu Trp Lys Met Lys Thr Gly Arg Arg Gly Ser Ala Asn Gly Lys
            2500                2505                2510        
Thr Leu Gly Glu Val Trp Lys Arg Glu Leu Asn Leu Leu Asp Lys Arg
        2515                2520                2525            
Gln Phe Glu Leu Tyr Lys Arg Thr Asp Ile Val Glu Val Asp Arg Asp
    2530                2535                2540                
Thr Ala Arg Arg His Leu Ala Glu Gly Lys Val Asp Thr Gly Val Ala
2545                2550                2555                2560
Val Ser Arg Gly Thr Ala Lys Leu Arg Trp Phe His Glu Arg Gly Tyr
                2565                2570                2575    
Val Lys Leu Glu Gly Arg Val Ile Asp Leu Gly Cys Gly Arg Gly Gly
            2580                2585                2590        
Trp Cys Tyr Tyr Ala Ala Ala Gln Lys Glu Val Ser Gly Val Lys Gly
        2595                2600                2605            
Phe Thr Leu Gly Arg Asp Gly His Glu Lys Pro Met Asn Val Gln Ser
    2610                2615                2620                
Leu Gly Trp Asn Ile Ile Thr Phe Lys Asp Lys Thr Asp Ile His Arg
2625                2630                2635                2640
Leu Glu Pro Val Lys Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser
                2645                2650                2655    
Ser Ser Ser Ser Val Thr Glu Gly Glu Arg Thr Val Arg Val Leu Asp
            2660                2665                2670        
Thr Val Glu Lys Trp Leu Ala Cys Gly Val Asp Asn Phe Cys Val Lys
        2675                2680                2685            
Val Leu Ala Pro Tyr Met Pro Asp Val Leu Glu Lys Leu Glu Leu Leu
    2690                2695                2700                
Gln Arg Arg Phe Gly Gly Thr Val Ile Arg Asn Pro Leu Ser Arg Asn
2705                2710                2715                2720
Ser Thr His Glu Met Tyr Tyr Val Ser Gly Ala Arg Ser Asn Val Thr
                2725                2730                2735    
Phe Thr Val Asn Gln Thr Ser Arg Leu Leu Met Arg Arg Met Arg Arg
            2740                2745                2750        
Pro Thr Gly Lys Val Thr Leu Glu Ala Asp Val Ile Leu Pro Ile Gly
        2755                2760                2765            
Thr Arg Ser Val Glu Thr Asp Lys Gly Pro Leu Asp Lys Glu Ala Ile
    2770                2775                2780                
Glu Glu Arg Val Glu Arg Ile Lys Ser Glu Tyr Met Thr Ser Trp Phe
2785                2790                2795                2800
Tyr Asp Asn Asp Asn Pro Tyr Arg Thr Trp His Tyr Cys Gly Ser Tyr
                2805                2810                2815    
Val Thr Lys Thr Ser Gly Ser Ala Ala Ser Met Val Asn Gly Val Ile
            2820                2825                2830        
Lys Ile Leu Thr Tyr Pro Trp Asp Arg Ile Glu Glu Val Thr Arg Met
        2835                2840                2845            
Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg Val Phe Lys Glu
    2850                2855                2860                
Lys Val Asp Thr Arg Ala Lys Asp Pro Pro Ala Gly Thr Arg Lys Ile
2865                2870                2875                2880
Met Lys Val Val Asn Arg Trp Leu Phe Arg His Leu Ala Arg Glu Lys
                2885                2890                2895    
Asn Pro Arg Leu Cys Thr Lys Glu Glu Phe Ile Ala Lys Val Arg Ser
            2900                2905                2910        
His Ala Ala Ile Gly Ala Tyr Leu Glu Glu Gln Glu Gln Trp Lys Thr
        2915                2920                2925            
Ala Asn Glu Ala Val Gln Asp Pro Lys Phe Trp Glu Leu Val Asp Glu
    2930                2935                2940                
Glu Arg Lys Leu His Gln Gln Gly Arg Cys Arg Thr Cys Val Tyr Asn
2945                2950                2955                2960
Met Met Gly Lys Arg Glu Lys Lys Leu Ser Glu Phe Gly Lys Ala Lys
                2965                2970                2975    
Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg Tyr Leu Glu
            2980                2985                2990        
Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp Ala Ser Arg Glu
        2995                3000                3005            
Asn Ser Gly Gly Gly Val Glu Gly Ile Gly Leu Gln Tyr Leu Gly Tyr
    3010                3015                3020                
Val Ile Arg Asp Leu Ala Ala Met Asp Gly Gly Gly Phe Tyr Ala Asp
3025                3030                3035                3040
Asp Thr Ala Gly Trp Asp Thr Arg Ile Thr Glu Ala Asp Leu Asp Asp
                3045                3050                3055    
Glu Gln Glu Ile Leu Asn Tyr Met Ser Pro His His Lys Lys Leu Ala
            3060                3065                3070        
Gln Ala Val Met Glu Met Thr Tyr Lys Asn Lys Val Val Lys Val Leu
        3075                3080                3085            
Arg Pro Ala Pro Gly Gly Lys Ala Tyr Met Asp Val Pro Ile Ser Arg
    3090                3095                3100                
Arg Asp Gln Arg Gly Ser Gly Gln Val Val Thr Tyr Ala Leu Asn Thr
3105                3110                3115                3120
Ile Thr Asn Leu Lys Val Gln Leu Ile Arg Met Ala Glu Ala Glu Met
                3125                3130                3135    
Val Ile His His Gln His Val Gln Asp Cys Asp Glu Ser Val Leu Thr
            3140                3145                3150        
Arg Leu Glu Ala Trp Leu Thr Glu His Gly Cys Asn Arg Leu Lys Arg
        3155                3160                3165            
Met Ala Val Ser Gly Asp Asp Cys Val Val Arg Pro Ile Asp Asp Arg
    3170                3175                3180                
Phe Gly Leu Ala Leu Ser His Leu Asn Ala Met Ser Lys Val Arg Lys
3185                3190                3195                3200
Asp Ile Ser Glu Trp Gln Pro Ser Lys Gly Trp Asn Asp Trp Glu Asn
                3205                3210                3215    
Val Pro Phe Cys Ser His His Phe His Glu Leu Gln Leu Lys Asp Gly
            3220                3225                3230        
Arg Arg Ile Val Val Pro Cys Arg Glu Gln Asp Glu Leu Ile Gly Arg
        3235                3240                3245            
Gly Arg Val Ser Pro Gly Asn Gly Trp Met Ile Lys Glu Thr Ala Cys
    3250                3255                3260                
Leu Ser Lys Ala Tyr Ala Asn Met Trp Ser Leu Met Tyr Phe His Lys
3265                3270                3275                3280
Arg Asp Met Arg Leu Leu Ser Leu Ala Val Ser Ser Ala Val Pro Thr
                3285                3290                3295    
Ser Trp Val Pro Gln Gly Arg Thr Thr Trp Ser Ile His Gly Lys Gly
            3300                3305                3310        
Glu Trp Met Thr Thr Glu Asp Met Leu Glu Val Trp Asn Arg Val Trp
        3315                3320                3325            
Ile Thr Asn Asn Pro His Met Gln Asp Lys Thr Met Val Lys Lys Trp
    3330                3335                3340                
Arg Asp Val Pro Tyr Leu Thr Lys Arg Gln Asp Lys Leu Cys Gly Ser
3345                3350                3355                3360
Leu Ile Gly Met Thr Asn Arg Ala Thr Trp Ala Ser His Ile His Leu
                3365                3370                3375    
Val Ile His Arg Ile Arg Thr Leu Ile Gly Gln Glu Lys Tyr Thr Asp
            3380                3385                3390        
Tyr Leu Thr Val Met Asp Arg Tyr Ser Val Asp Ala Asp Leu Gln Leu
        3395                3400                3405            
Gly Glu Leu Ile
    3410        


<210> 4
<211> 3412
<212> PRT
<213> Coquillettidia fuscopennata

<400> 4
Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val
 1               5                  10                  15      
Arg Arg Gly Val Arg Ser Leu Ser Asn Lys Ile Lys Gln Lys Thr Lys
            20                  25                  30          
Gln Ile Gly Asn Arg Pro Gly Pro Ser Arg Gly Val Gln Gly Phe Ile
        35                  40                  45              
Phe Phe Phe Leu Phe Asn Ile Leu Thr Gly Lys Lys Ile Thr Ala His
    50                  55                  60                  
Leu Lys Arg Leu Trp Lys Met Leu Asp Pro Arg Gln Gly Leu Ala Val
65                  70                  75                  80  
Leu Arg Lys Val Lys Arg Val Val Ala Ser Leu Met Arg Gly Leu Ser
                85                  90                  95      
Ser Arg Lys Arg Arg Ser His Asp Val Leu Thr Val Gln Phe Leu Ile
            100                 105                 110         
Leu Gly Met Leu Leu Met Thr Gly Gly Val Thr Leu Val Arg Lys Asn
        115                 120                 125             
Arg Trp Leu Leu Leu Asn Val Thr Ser Glu Asp Leu Gly Lys Thr Phe
    130                 135                 140                 
Ser Val Gly Thr Gly Asn Cys Thr Thr Asn Ile Leu Glu Ala Lys Tyr
145                 150                 155                 160 
Trp Cys Pro Asp Ser Met Glu Tyr Asn Cys Pro Asn Leu Ser Pro Arg
                165                 170                 175     
Glu Glu Pro Asp Asp Ile Asp Cys Trp Cys Tyr Gly Val Glu Asn Val
            180                 185                 190         
Arg Val Ala Tyr Gly Lys Cys Asp Ser Ala Gly Arg Ser Arg Arg Ser
        195                 200                 205             
Arg Arg Ala Ile Asp Leu Pro Thr His Glu Asn His Gly Leu Lys Thr
    210                 215                 220                 
Arg Gln Glu Lys Trp Met Thr Gly Arg Met Gly Glu Arg Gln Leu Gln
225                 230                 235                 240 
Lys Ile Glu Arg Trp Phe Val Arg Asn Pro Phe Phe Ala Val Thr Ala
                245                 250                 255     
Leu Thr Ile Ala Tyr Leu Val Gly Ser Asn Met Thr Gln Arg Val Val
            260                 265                 270         
Ile Ala Leu Leu Val Leu Ala Val Gly Pro Ala Tyr Ser Ala His Cys
        275                 280                 285             
Ile Gly Ile Thr Asp Arg Asp Phe Ile Glu Gly Val His Gly Gly Thr
    290                 295                 300                 
Trp Val Ser Ala Thr Leu Glu Gln Asp Lys Cys Val Thr Val Met Ala
305                 310                 315                 320 
Pro Asp Lys Pro Ser Leu Asp Ile Ser Leu Glu Thr Val Ala Ile Asp
                325                 330                 335     
Arg Pro Ala Glu Val Arg Lys Val Cys Tyr Asn Ala Val Leu Thr His
            340                 345                 350         
Val Lys Ile Asn Asp Lys Cys Pro Ser Thr Gly Glu Ala His Leu Ala
        355                 360                 365             
Glu Glu Asn Glu Gly Asp Asn Ala Cys Lys Arg Thr Tyr Ser Asp Arg
    370                 375                 380                 
Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Val Ala
385                 390                 395                 400 
Cys Ala Lys Phe Thr Cys Ala Lys Ser Met Ser Leu Phe Glu Val Asp
                405                 410                 415     
Gln Thr Lys Ile Gln Tyr Val Ile Arg Ala Gln Leu His Val Gly Ala
            420                 425                 430         
Lys Gln Glu Asn Trp Thr Thr Asp Ile Lys Thr Leu Arg Phe Asp Ala
        435                 440                 445             
Leu Ser Gly Ser Gln Glu Val Glu Phe Ile Gly Tyr Gly Lys Ala Thr
    450                 455                 460                 
Leu Glu Cys Gln Val Gln Thr Ala Val Asp Phe Gly Asn Ser Tyr Ile
465                 470                 475                 480 
Ala Glu Met Glu Thr Glu Ser Trp Ile Val Asp Arg Gln Trp Ala Gln
                485                 490                 495     
Asp Leu Thr Leu Pro Trp Gln Ser Gly Ser Gly Gly Val Trp Arg Glu
            500                 505                 510         
Met His His Leu Val Glu Phe Glu Pro Pro His Ala Ala Thr Ile Arg
        515                 520                 525             
Val Leu Ala Leu Gly Asn Gln Glu Gly Ser Leu Lys Thr Ala Leu Thr
    530                 535                 540                 
Gly Ala Met Arg Val Thr Lys Asp Thr Asn Asp Asn Asn Leu Tyr Lys
545                 550                 555                 560 
Leu His Gly Gly His Val Ser Cys Arg Val Lys Leu Ser Ala Leu Thr
                565                 570                 575     
Leu Lys Gly Thr Ser Tyr Lys Ile Cys Thr Asp Lys Met Phe Phe Val
            580                 585                 590         
Lys Asn Pro Thr Asp Thr Gly His Gly Thr Val Val Met Gln Val Lys
        595                 600                 605             
Val Ser Lys Gly Ala Pro Cys Arg Ile Pro Val Ile Val Ala Asp Asp
    610                 615                 620                 
Leu Thr Ala Ala Ile Asn Lys Gly Ile Leu Val Thr Val Asn Pro Ile
625                 630                 635                 640 
Ala Ser Thr Asn Asp Asp Glu Val Leu Ile Glu Val Asn Pro Pro Phe
                645                 650                 655     
Gly Asp Ser Tyr Ile Ile Val Gly Arg Gly Asp Ser Arg Leu Thr Tyr
            660                 665                 670         
Gln Trp His Lys Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln Thr
        675                 680                 685             
Met Lys Gly Val Glu Arg Leu Ala Val Met Gly Asp Thr Ala Trp Asp
    690                 695                 700                 
Phe Ser Ser Ala Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile His
705                 710                 715                 720 
Thr Val Phe Gly Ser Ala Phe Gln Gly Leu Phe Gly Gly Leu Asn Trp
                725                 730                 735     
Ile Thr Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn
            740                 745                 750         
Thr Arg Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile
        755                 760                 765             
Met Met Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile
    770                 775                 780                 
Asn Phe Gly Lys Arg Glu Leu Lys Cys Gly Asp Gly Ile Phe Ile Phe
785                 790                 795                 800 
Arg Asp Ser Asp Asp Trp Leu Asn Lys Tyr Ser Tyr Tyr Pro Glu Asp
                805                 810                 815     
Pro Val Lys Leu Ala Ser Ile Val Lys Ala Ser Phe Glu Glu Gly Lys
            820                 825                 830         
Cys Gly Leu Asn Ser Val Asp Ser Leu Glu His Glu Met Trp Arg Ser
        835                 840                 845             
Arg Ala Asp Glu Ile Asn Ala Ile Phe Glu Glu Asn Glu Val Asp Ile
    850                 855                 860                 
Ser Val Val Val Gln Asp Pro Lys Asn Val Tyr Gln Arg Gly Thr His
865                 870                 875                 880 
Pro Phe Ser Arg Ile Arg Asp Gly Leu Gln Tyr Gly Trp Lys Thr Trp
                885                 890                 895     
Gly Lys Asn Leu Val Phe Ser Pro Gly Arg Lys Asn Gly Ser Phe Ile
            900                 905                 910         
Ile Asp Gly Lys Ser Arg Lys Glu Cys Pro Phe Ser Asn Arg Val Trp
        915                 920                 925             
Asn Ser Phe Gln Ile Glu Glu Phe Gly Thr Gly Val Phe Thr Thr Arg
    930                 935                 940                 
Val Tyr Met Asp Ala Val Phe Glu Tyr Thr Ile Asp Cys Asp Gly Ser
945                 950                 955                 960 
Ile Leu Gly Ala Ala Val Asn Gly Lys Lys Ser Ala His Gly Ser Pro
                965                 970                 975     
Thr Phe Trp Met Gly Ser His Glu Val Asn Gly Thr Trp Met Ile His
            980                 985                 990         
Thr Leu Glu Ala Leu Asp Tyr Lys Glu Cys Glu Trp Pro Leu Thr His
        995                 1000                1005            
Thr Ile Gly Thr Ser Val Glu Glu Ser Glu Met Phe Met Pro Arg Ser
    1010                1015                1020                
Ile Gly Gly Pro Val Ser Ser His Asn His Ile Pro Gly Tyr Lys Val
1025                1030                1035                1040
Gln Thr Asn Gly Pro Trp Met Gln Val Pro Leu Glu Val Lys Arg Glu
                1045                1050                1055    
Ala Cys Pro Gly Thr Ser Val Ile Ile Asp Gly Asn Cys Asp Gly Arg
            1060                1065                1070        
Gly Lys Ser Thr Arg Ser Thr Thr Asp Ser Gly Lys Val Ile Pro Glu
        1075                1080                1085            
Trp Cys Cys Arg Ser Cys Thr Met Pro Pro Val Ser Phe His Gly Ser
    1090                1095                1100                
Asp Gly Cys Trp Tyr Pro Met Glu Ile Arg Pro Arg Lys Thr His Glu
1105                1110                1115                1120
Ser His Leu Val Arg Ser Trp Val Thr Ala Gly Glu Ile His Ala Val
                1125                1130                1135    
Pro Phe Gly Leu Val Ser Met Met Ile Ala Met Glu Val Val Leu Arg
            1140                1145                1150        
Lys Arg Gln Gly Pro Lys Gln Met Leu Val Gly Gly Val Val Leu Leu
        1155                1160                1165            
Gly Ala Met Leu Val Gly Gln Val Thr Leu Leu Asp Leu Leu Lys Leu
    1170                1175                1180                
Thr Val Ala Val Gly Leu His Phe His Glu Met Asn Asn Gly Gly Asp
1185                1190                1195                1200
Ala Met Tyr Met Ala Leu Ile Ala Ala Phe Ser Ile Arg Pro Gly Leu
                1205                1210                1215    
Leu Ile Gly Phe Gly Leu Arg Thr Leu Trp Ser Pro Arg Glu Arg Leu
            1220                1225                1230        
Val Leu Thr Leu Gly Ala Ala Met Val Glu Ile Ala Leu Gly Gly Val
        1235                1240                1245            
Met Gly Gly Leu Trp Lys Tyr Leu Asn Ala Val Ser Leu Cys Ile Leu
    1250                1255                1260                
Thr Ile Asn Ala Val Ala Ser Arg Lys Ala Ser Asn Thr Ile Leu Pro
1265                1270                1275                1280
Leu Met Ala Leu Leu Thr Pro Val Thr Met Ala Glu Val Arg Leu Ala
                1285                1290                1295    
Ala Met Phe Phe Cys Ala Val Val Ile Ile Gly Val Leu His Gln Asn
            1300                1305                1310        
Phe Lys Asp Thr Ser Met Gln Lys Thr Ile Pro Leu Val Ala Leu Thr
        1315                1320                1325            
Leu Thr Ser Tyr Leu Gly Leu Thr Gln Pro Phe Leu Gly Leu Cys Ala
    1330                1335                1340                
Phe Leu Ala Thr Arg Ile Phe Gly Arg Arg Ser Ile Pro Val Asn Glu
1345                1350                1355                1360
Ala Leu Ala Ala Ala Gly Leu Val Gly Val Leu Ala Gly Leu Ala Phe
                1365                1370                1375    
Gln Glu Met Glu Asn Phe Leu Gly Pro Ile Ala Val Gly Gly Leu Leu
            1380                1385                1390        
Met Met Leu Val Ser Val Ala Gly Arg Val Asp Gly Leu Glu Leu Lys
        1395                1400                1405            
Lys Leu Gly Glu Val Ser Trp Glu Glu Glu Ala Glu Ile Ser Gly Ser
    1410                1415                1420                
Ser Ala Arg Tyr Asp Val Ala Leu Ser Glu Gln Gly Glu Phe Lys Leu
1425                1430                1435                1440
Leu Ser Glu Glu Lys Val Pro Trp Asp Gln Val Val Met Thr Ser Leu
                1445                1450                1455    
Ala Leu Val Gly Ala Ala Leu His Pro Phe Ala Leu Leu Leu Val Leu
            1460                1465                1470        
Ala Gly Trp Leu Phe His Val Arg Gly Ala Arg Arg Ser Gly Asp Val
        1475                1480                1485            
Leu Trp Asp Ile Pro Thr Pro Lys Ile Ile Glu Glu Cys Glu His Leu
    1490                1495                1500                
Glu Asp Gly Ile Tyr Gly Ile Phe Gln Ser Thr Phe Leu Gly Ala Ser
1505                1510                1515                1520
Gln Arg Gly Val Gly Val Ala Gln Gly Gly Val Phe His Thr Met Trp
                1525                1530                1535    
His Val Thr Arg Gly Ala Phe Leu Val Arg Asn Gly Lys Lys Leu Ile
            1540                1545                1550        
Pro Ser Trp Ala Ser Val Lys Glu Asp Leu Val Ala Tyr Gly Gly Ser
        1555                1560                1565            
Trp Lys Leu Glu Gly Arg Trp Asp Gly Glu Glu Glu Val Gln Leu Ile
    1570                1575                1580                
Ala Ala Val Pro Gly Lys Asn Val Val Asn Val Gln Thr Lys Pro Ser
1585                1590                1595                1600
Leu Phe Lys Val Arg Asn Gly Gly Glu Ile Gly Ala Val Ala Leu Asp
                1605                1610                1615    
Tyr Pro Ser Gly Thr Ser Gly Ser Pro Ile Val Asn Arg Asn Gly Glu
            1620                1625                1630        
Val Ile Gly Leu Tyr Gly Asn Gly Ile Leu Val Gly Asp Asn Ser Phe
        1635                1640                1645            
Val Ser Ala Ile Ser Gln Thr Glu Val Lys Glu Glu Gly Lys Glu Glu
    1650                1655                1660                
Leu Gln Glu Ile Pro Thr Met Leu Lys Lys Gly Met Thr Thr Val Leu
1665                1670                1675                1680
Asp Phe His Pro Gly Ala Gly Lys Thr Arg Arg Phe Leu Pro Gln Ile
                1685                1690                1695    
Leu Ala Glu Cys Ala Arg Arg Arg Leu Arg Thr Leu Val Leu Ala Pro
            1700                1705                1710        
Thr Arg Val Val Leu Ser Glu Met Lys Glu Ala Phe His Gly Leu Asp
        1715                1720                1725            
Val Lys Phe His Thr Gln Ala Phe Ser Ala His Gly Ser Gly Arg Glu
    1730                1735                1740                
Val Ile Asp Ala Met Cys His Ala Thr Leu Thr Tyr Arg Met Leu Glu
1745                1750                1755                1760
Pro Thr Arg Val Val Asn Trp Glu Val Ile Ile Met Asp Glu Ala His
                1765                1770                1775    
Phe Leu Asp Pro Ala Ser Ile Ala Ala Arg Gly Trp Ala Ala His Arg
            1780                1785                1790        
Ala Arg Ala Asn Glu Ser Ala Thr Ile Leu Met Thr Ala Thr Pro Pro
        1795                1800                1805            
Gly Thr Ser Asp Glu Phe Pro His Ser Asn Gly Glu Ile Glu Asp Val
    1810                1815                1820                
Gln Thr Asp Ile Pro Ser Glu Pro Trp Asn Thr Gly His Asp Trp Ile
1825                1830                1835                1840
Leu Ala Asp Lys Arg Pro Thr Ala Trp Phe Leu Pro Ser Ile Arg Ala
                1845                1850                1855    
Ala Asn Val Met Ala Ala Ser Leu Arg Lys Ala Gly Lys Ser Val Val
            1860                1865                1870        
Val Leu Asn Arg Lys Thr Phe Glu Arg Glu Tyr Pro Thr Ile Lys Gln
        1875                1880                1885            
Lys Lys Pro Asp Phe Ile Leu Ala Thr Asp Ile Ala Glu Met Gly Ala
    1890                1895                1900                
Asn Leu Cys Val Glu Arg Val Leu Asp Cys Arg Thr Ala Phe Lys Pro
1905                1910                1915                1920
Val Leu Val Asp Glu Gly Arg Lys Val Ala Ile Lys Gly Pro Leu Arg
                1925                1930                1935    
Ile Ser Ala Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn
            1940                1945                1950        
Pro Asn Arg Asp Gly Asp Ser Tyr Tyr Tyr Ser Glu Pro Thr Ser Glu
        1955                1960                1965            
Asn Asn Ala His His Val Cys Trp Leu Glu Ala Ser Met Leu Leu Asp
    1970                1975                1980                
Asn Met Glu Val Arg Gly Gly Met Val Ala Pro Leu Tyr Gly Val Glu
1985                1990                1995                2000
Gly Thr Lys Thr Pro Val Ser Pro Gly Glu Met Arg Leu Arg Asp Asp
                2005                2010                2015    
Gln Arg Lys Val Phe Arg Glu Leu Val Arg Asn Cys Asp Leu Pro Val
            2020                2025                2030        
Trp Leu Ser Trp Gln Val Ala Lys Ala Gly Leu Lys Thr Asn Asp Arg
        2035                2040                2045            
Lys Trp Cys Phe Glu Gly Pro Glu Glu His Glu Ile Leu Asn Asp Ser
    2050                2055                2060                
Gly Glu Thr Val Lys Cys Arg Ala Pro Gly Gly Ala Lys Lys Pro Leu
2065                2070                2075                2080
Arg Pro Arg Trp Cys Asp Glu Arg Val Ser Ser Asp Gln Ser Ala Leu
                2085                2090                2095    
Ser Glu Phe Ile Lys Phe Ala Glu Gly Arg Arg Gly Ala Ala Glu Val
            2100                2105                2110        
Leu Val Val Leu Ser Glu Leu Pro Asp Phe Leu Ala Lys Lys Gly Gly
        2115                2120                2125            
Glu Ala Met Asp Thr Ile Ser Val Phe Leu His Ser Glu Glu Gly Ser
    2130                2135                2140                
Arg Ala Tyr Arg Asn Ala Leu Ser Met Met Pro Glu Ala Met Thr Ile
2145                2150                2155                2160
Val Met Leu Phe Ile Leu Ala Gly Leu Leu Thr Ser Gly Met Val Ile
                2165                2170                2175    
Phe Phe Met Ser Pro Lys Gly Ile Ser Arg Met Ser Met Ala Met Gly
            2180                2185                2190        
Thr Met Ala Gly Cys Gly Tyr Leu Met Phe Leu Gly Gly Val Lys Pro
        2195                2200                2205            
Thr His Ile Ser Tyr Ile Met Leu Ile Phe Phe Val Leu Met Val Val
    2210                2215                2220                
Val Ile Pro Glu Pro Gly Gln Gln Arg Ser Ile Gln Asp Asn Gln Val
2225                2230                2235                2240
Ala Tyr Leu Ile Ile Gly Ile Leu Thr Leu Val Ser Ala Val Ala Ala
                2245                2250                2255    
Asn Glu Leu Gly Met Leu Glu Lys Thr Lys Glu Asp Leu Phe Gly Lys
            2260                2265                2270        
Lys Asn Leu Ile Pro Ser Ser Ala Ser Pro Trp Ser Trp Pro Asp Leu
        2275                2280                2285            
Asp Leu Lys Pro Gly Ala Ala Trp Thr Val Tyr Val Gly Ile Val Thr
    2290                2295                2300                
Met Leu Ser Pro Met Leu His His Trp Ile Lys Val Glu Tyr Gly Asn
2305                2310                2315                2320
Leu Ser Leu Ser Gly Ile Ala Gln Ser Ala Ser Val Leu Ser Phe Met
                2325                2330                2335    
Asp Lys Gly Ile Pro Phe Met Lys Met Asn Ile Ser Val Ile Met Leu
            2340                2345                2350        
Leu Val Ser Gly Trp Asn Ser Ile Thr Val Met Pro Leu Leu Cys Gly
        2355                2360                2365            
Ile Gly Cys Ala Met Leu His Trp Ser Leu Ile Leu Pro Gly Ile Lys
    2370                2375                2380                
Ala Gln Gln Ser Lys Leu Ala Gln Arg Arg Val Phe His Gly Val Ala
2385                2390                2395                2400
Lys Asn Pro Val Val Asp Gly Asn Pro Thr Val Asp Ile Glu Glu Ala
                2405                2410                2415    
Pro Glu Met Pro Ala Leu Tyr Glu Lys Lys Leu Ala Leu Tyr Leu Leu
            2420                2425                2430        
Leu Ala Leu Ser Leu Ala Ser Val Ala Met Cys Arg Thr Pro Phe Ser
        2435                2440                2445            
Leu Ala Glu Gly Ile Val Leu Ala Ser Ala Ala Leu Gly Pro Leu Ile
    2450                2455                2460                
Glu Gly Asn Thr Ser Leu Leu Trp Asn Gly Pro Met Ala Val Ser Met
2465                2470                2475                2480
Thr Gly Val Met Arg Gly Asn His Tyr Ala Phe Val Gly Val Met Tyr
                2485                2490                2495    
Asn Leu Trp Lys Met Lys Thr Gly Arg Arg Gly Ser Ala Asn Gly Lys
            2500                2505                2510        
Thr Leu Gly Glu Val Trp Lys Arg Glu Leu Asn Leu Leu Asp Lys Arg
        2515                2520                2525            
Gln Phe Glu Leu Tyr Lys Arg Thr Asp Ile Val Glu Val Asp Arg Asp
    2530                2535                2540                
Thr Ala Arg Arg His Leu Ala Glu Gly Lys Val Asp Thr Gly Val Ala
2545                2550                2555                2560
Val Ser Arg Gly Thr Ala Lys Leu Arg Trp Phe His Glu Arg Gly Tyr
                2565                2570                2575    
Val Lys Leu Glu Gly Arg Val Ile Asp Leu Gly Cys Gly Arg Gly Gly
            2580                2585                2590        
Trp Cys Tyr Tyr Ala Ala Ala Gln Lys Glu Val Ser Gly Val Lys Gly
        2595                2600                2605            
Phe Thr Leu Gly Arg Asp Gly His Glu Lys Pro Met Asn Val Gln Ser
    2610                2615                2620                
Leu Gly Trp Asn Ile Ile Thr Phe Lys Asp Lys Thr Asp Ile His Arg
2625                2630                2635                2640
Leu Glu Pro Val Lys Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser
                2645                2650                2655    
Ser Ser Ser Ser Val Thr Glu Gly Glu Arg Thr Val Arg Val Leu Asp
            2660                2665                2670        
Thr Val Glu Lys Trp Leu Ala Cys Gly Val Asp Asn Phe Cys Val Lys
        2675                2680                2685            
Val Leu Ala Pro Tyr Met Pro Asp Val Leu Glu Lys Leu Glu Leu Leu
    2690                2695                2700                
Gln Arg Arg Phe Gly Gly Thr Val Ile Arg Asn Pro Leu Ser Arg Asn
2705                2710                2715                2720
Ser Thr His Glu Met Tyr Tyr Val Ser Gly Ala Arg Ser Asn Val Thr
                2725                2730                2735    
Phe Thr Val Asn Gln Thr Ser Arg Leu Leu Met Arg Arg Met Arg Arg
            2740                2745                2750        
Pro Thr Gly Lys Val Thr Leu Glu Ala Asp Val Ile Leu Pro Ile Gly
        2755                2760                2765            
Thr Arg Ser Val Glu Thr Asp Lys Gly Pro Leu Asp Lys Glu Ala Ile
    2770                2775                2780                
Glu Glu Arg Val Glu Arg Ile Lys Ser Glu Tyr Met Thr Ser Trp Phe
2785                2790                2795                2800
Tyr Asp Asn Asp Asn Pro Tyr Arg Thr Trp His Tyr Cys Gly Ser Tyr
                2805                2810                2815    
Val Thr Lys Thr Ser Gly Ser Ala Ala Ser Met Val Asn Gly Val Ile
            2820                2825                2830        
Lys Ile Leu Thr Tyr Pro Trp Asp Arg Ile Glu Glu Val Thr Arg Met
        2835                2840                2845            
Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg Val Phe Lys Glu
    2850                2855                2860                
Lys Val Asp Thr Arg Ala Lys Asp Pro Pro Ala Gly Thr Arg Lys Ile
2865                2870                2875                2880
Met Lys Val Val Asn Arg Trp Leu Phe Arg His Leu Ala Arg Glu Lys
                2885                2890                2895    
Asn Pro Arg Leu Cys Thr Lys Glu Glu Phe Ile Ala Lys Val Arg Ser
            2900                2905                2910        
His Ala Ala Ile Gly Ala Tyr Leu Glu Glu Gln Glu Gln Trp Lys Thr
        2915                2920                2925            
Ala Asn Glu Ala Val Gln Asp Pro Lys Phe Trp Glu Leu Val Asp Glu
    2930                2935                2940                
Glu Arg Lys Leu His Gln Gln Gly Arg Cys Arg Thr Cys Val Tyr Asn
2945                2950                2955                2960
Met Met Gly Lys Arg Glu Lys Lys Leu Ser Glu Phe Gly Lys Ala Lys
                2965                2970                2975    
Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg Tyr Leu Glu
            2980                2985                2990        
Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp Ala Ser Arg Glu
        2995                3000                3005            
Asn Ser Gly Gly Gly Val Glu Gly Ile Gly Leu Gln Tyr Leu Gly Tyr
    3010                3015                3020                
Val Ile Arg Asp Leu Ala Ala Met Asp Gly Gly Gly Phe Tyr Ala Asp
3025                3030                3035                3040
Asp Thr Ala Gly Trp Asp Thr Arg Ile Thr Glu Ala Asp Leu Asp Asp
                3045                3050                3055    
Glu Gln Glu Ile Leu Asn Tyr Met Ser Pro His His Lys Lys Leu Ala
            3060                3065                3070        
Gln Ala Val Met Glu Met Thr Tyr Lys Asn Lys Val Val Lys Val Leu
        3075                3080                3085            
Arg Pro Ala Pro Gly Gly Lys Ala Tyr Met Asp Val Pro Ile Ser Arg
    3090                3095                3100                
Arg Asp Gln Arg Gly Ser Gly Gln Val Val Thr Tyr Ala Leu Asn Thr
3105                3110                3115                3120
Ile Thr Asn Leu Lys Val Gln Leu Ile Arg Met Ala Glu Ala Glu Met
                3125                3130                3135    
Val Ile His His Gln His Val Gln Asp Cys Asp Glu Ser Val Leu Thr
            3140                3145                3150        
Arg Leu Glu Ala Trp Leu Thr Glu His Gly Cys Asn Arg Leu Lys Arg
        3155                3160                3165            
Met Ala Val Ser Gly Asp Asp Cys Val Val Arg Pro Ile Asp Asp Arg
    3170                3175                3180                
Phe Gly Leu Ala Leu Ser His Leu Asn Ala Met Ser Lys Val Arg Lys
3185                3190                3195                3200
Asp Ile Ser Glu Trp Gln Pro Ser Lys Gly Trp Asn Asp Trp Glu Asn
                3205                3210                3215    
Val Pro Phe Cys Ser His His Phe His Glu Leu Gln Leu Lys Asp Gly
            3220                3225                3230        
Arg Arg Ile Val Val Pro Cys Arg Glu Gln Asp Glu Leu Ile Gly Arg
        3235                3240                3245            
Gly Arg Val Ser Pro Gly Asn Gly Trp Met Ile Lys Glu Thr Ala Cys
    3250                3255                3260                
Leu Ser Lys Ala Tyr Ala Asn Met Trp Ser Leu Met Tyr Phe His Lys
3265                3270                3275                3280
Arg Asp Met Arg Leu Leu Ser Leu Ala Val Ser Ser Ala Val Pro Thr
                3285                3290                3295    
Ser Trp Val Pro Gln Gly Arg Thr Thr Trp Ser Ile His Gly Lys Gly
            3300                3305                3310        
Glu Trp Met Thr Thr Glu Asp Met Leu Glu Val Trp Asn Arg Val Trp
        3315                3320                3325            
Ile Thr Asn Asn Pro His Met Gln Asp Lys Thr Met Val Lys Lys Trp
    3330                3335                3340                
Arg Asp Val Pro Tyr Leu Thr Lys Arg Gln Asp Lys Leu Cys Gly Ser
3345                3350                3355                3360
Leu Ile Gly Met Thr Asn Arg Ala Thr Trp Ala Ser His Ile His Leu
                3365                3370                3375    
Val Ile His Arg Ile Arg Thr Leu Ile Gly Gln Glu Lys Tyr Thr Asp
            3380                3385                3390        
Tyr Leu Thr Val Met Asp Arg Tyr Ser Val Asp Ala Asp Leu Gln Leu
        3395                3400                3405            
Gly Glu Leu Ile
    3410        


<210> 5
<211> 684
<212> PRT
<213> Coquillettidia fuscopennata

<400> 5
Ile Leu Gly Met Leu Leu Met Thr Gly Gly Val Thr Leu Val Arg Lys
 1               5                  10                  15      
Asn Arg Trp Leu Leu Leu Asn Val Thr Ser Glu Asp Leu Gly Lys Thr
            20                  25                  30          
Phe Ser Val Gly Thr Gly Asn Cys Thr Thr Asn Ile Leu Glu Ala Lys
        35                  40                  45              
Tyr Trp Cys Pro Asp Ser Met Glu Tyr Asn Cys Pro Asn Leu Ser Pro
    50                  55                  60                  
Arg Glu Glu Pro Asp Asp Ile Asp Cys Trp Cys Tyr Gly Val Glu Asn
65                  70                  75                  80  
Val Arg Val Ala Tyr Gly Lys Cys Asp Ser Ala Gly Arg Ser Arg Arg
                85                  90                  95      
Ser Arg Arg Ala Ile Asp Leu Pro Thr His Glu Asn His Gly Leu Lys
            100                 105                 110         
Thr Arg Gln Glu Lys Trp Met Thr Gly Arg Met Gly Glu Arg Gln Leu
        115                 120                 125             
Gln Lys Ile Glu Arg Trp Phe Val Arg Asn Pro Phe Phe Ala Val Thr
    130                 135                 140                 
Ala Leu Thr Ile Ala Tyr Leu Val Gly Ser Asn Met Thr Gln Arg Val
145                 150                 155                 160 
Val Ile Ala Leu Leu Val Leu Ala Val Gly Pro Ala Tyr Ser Ala His
                165                 170                 175     
Cys Ile Gly Ile Thr Asp Arg Asp Phe Ile Glu Gly Val His Gly Gly
            180                 185                 190         
Thr Trp Val Ser Ala Thr Leu Glu Gln Asp Lys Cys Val Thr Val Met
        195                 200                 205             
Ala Pro Asp Lys Pro Ser Leu Asp Ile Ser Leu Glu Thr Val Ala Ile
    210                 215                 220                 
Asp Arg Pro Ala Glu Val Arg Lys Val Cys Tyr Asn Ala Val Leu Thr
225                 230                 235                 240 
His Val Lys Ile Asn Asp Lys Cys Pro Ser Thr Gly Glu Ala His Leu
                245                 250                 255     
Ala Glu Glu Asn Glu Gly Asp Asn Ala Cys Lys Arg Thr Tyr Ser Asp
            260                 265                 270         
Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Val
        275                 280                 285             
Ala Cys Ala Lys Phe Thr Cys Ala Lys Ser Met Ser Leu Phe Glu Val
    290                 295                 300                 
Asp Gln Thr Lys Ile Gln Tyr Val Ile Arg Ala Gln Leu His Val Gly
305                 310                 315                 320 
Ala Lys Gln Glu Asn Trp Thr Thr Asp Ile Lys Thr Leu Lys Phe Asp
                325                 330                 335     
Ala Leu Ser Gly Ser Gln Glu Val Glu Phe Ile Gly Tyr Gly Lys Ala
            340                 345                 350         
Thr Leu Glu Cys Gln Val Gln Thr Ala Val Asp Phe Gly Asn Ser Tyr
        355                 360                 365             
Ile Ala Glu Met Glu Thr Glu Ser Trp Ile Val Asp Arg Gln Trp Ala
    370                 375                 380                 
Gln Asp Leu Thr Leu Pro Trp Gln Ser Gly Ser Gly Gly Val Trp Arg
385                 390                 395                 400 
Glu Met His His Leu Val Glu Phe Glu Pro Pro His Ala Ala Thr Ile
                405                 410                 415     
Arg Val Leu Ala Leu Gly Asn Gln Glu Gly Ser Leu Lys Thr Ala Leu
            420                 425                 430         
Thr Gly Ala Met Arg Val Thr Lys Asp Thr Asn Asp Asn Asn Leu Tyr
        435                 440                 445             
Lys Leu His Gly Gly His Val Ser Cys Arg Val Lys Leu Ser Ala Leu
    450                 455                 460                 
Thr Leu Lys Gly Thr Ser Tyr Lys Ile Cys Thr Asp Lys Met Phe Phe
465                 470                 475                 480 
Val Lys Asn Pro Thr Asp Thr Gly His Gly Thr Val Val Met Gln Val
                485                 490                 495     
Lys Val Ser Lys Gly Ala Pro Cys Arg Ile Pro Val Ile Val Ala Asp
            500                 505                 510         
Asp Leu Thr Ala Ala Ile Asn Lys Gly Ile Leu Val Thr Val Asn Pro
        515                 520                 525             
Ile Ala Ser Thr Asn Asp Asp Glu Val Leu Ile Glu Val Asn Pro Pro
    530                 535                 540                 
Phe Gly Asp Ser Tyr Ile Ile Val Gly Arg Gly Asp Ser Arg Leu Thr
545                 550                 555                 560 
Tyr Gln Trp His Lys Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln
                565                 570                 575     
Thr Met Lys Gly Val Glu Arg Leu Ala Val Met Gly Asp Thr Ala Trp
            580                 585                 590         
Asp Phe Ser Ser Ala Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile
        595                 600                 605             
His Thr Val Phe Gly Ser Ala Phe Gln Gly Leu Phe Gly Gly Leu Asn
    610                 615                 620                 
Trp Ile Thr Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile
625                 630                 635                 640 
Asn Thr Arg Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val
                645                 650                 655     
Ile Met Met Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala
            660                 665                 670         
Ile Asn Phe Gly Lys Arg Glu Leu Lys Cys Gly Asp
        675                 680                 


<210> 6
<211> 678
<212> PRT
<213> Coquillettidia fuscopennata

<400> 6
Gly Met Leu Leu Met Thr Gly Gly Val Thr Leu Val Arg Lys Asn Arg
 1               5                  10                  15      
Trp Leu Leu Leu Asn Val Thr Ser Glu Asp Leu Gly Lys Thr Phe Ser
            20                  25                  30          
Val Gly Thr Gly Asn Cys Thr Thr Asn Ile Leu Glu Ala Lys Tyr Trp
        35                  40                  45              
Cys Pro Asp Ser Met Glu Tyr Asn Cys Pro Asn Leu Ser Pro Arg Glu
    50                  55                  60                  
Glu Pro Asp Asp Ile Asp Cys Trp Cys Tyr Gly Val Glu Asn Val Arg
65                  70                  75                  80  
Val Ala Tyr Gly Lys Cys Asp Ser Ala Gly Arg Ser Arg Arg Ser Arg
                85                  90                  95      
Arg Ala Ile Asp Leu Pro Thr His Glu Asn His Gly Leu Lys Thr Arg
            100                 105                 110         
Gln Glu Lys Trp Met Thr Gly Arg Met Gly Glu Arg Gln Leu Gln Lys
        115                 120                 125             
Ile Glu Arg Trp Phe Val Arg Asn Pro Phe Phe Ala Val Thr Ala Leu
    130                 135                 140                 
Thr Ile Ala Tyr Leu Val Gly Ser Asn Met Thr Gln Arg Val Val Ile
145                 150                 155                 160 
Ala Leu Leu Val Leu Ala Val Gly Pro Ala Tyr Ser Ala His Cys Ile
                165                 170                 175     
Gly Ile Thr Asp Arg Asp Phe Ile Glu Gly Val His Gly Gly Thr Trp
            180                 185                 190         
Val Ser Ala Thr Leu Glu Gln Asp Lys Cys Val Thr Val Met Ala Pro
        195                 200                 205             
Asp Lys Pro Ser Leu Asp Ile Ser Leu Glu Thr Val Ala Ile Asp Arg
    210                 215                 220                 
Pro Ala Glu Val Arg Lys Val Cys Tyr Asn Ala Val Leu Thr His Val
225                 230                 235                 240 
Lys Ile Asn Asp Lys Cys Pro Ser Thr Gly Glu Ala His Leu Ala Glu
                245                 250                 255     
Glu Asn Glu Gly Asp Asn Ala Cys Lys Arg Thr Tyr Ser Asp Arg Gly
            260                 265                 270         
Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Val Ala Cys
        275                 280                 285             
Ala Lys Phe Thr Cys Ala Lys Ser Met Ser Leu Phe Glu Val Asp Gln
    290                 295                 300                 
Thr Lys Ile Gln Tyr Val Ile Arg Ala Gln Leu His Val Gly Ala Lys
305                 310                 315                 320 
Gln Glu Asn Trp Thr Thr Asp Ile Lys Thr Leu Arg Phe Asp Ala Leu
                325                 330                 335     
Ser Gly Ser Gln Glu Val Glu Phe Ile Gly Tyr Gly Lys Ala Thr Leu
            340                 345                 350         
Glu Cys Gln Val Gln Thr Ala Val Asp Phe Gly Asn Ser Tyr Ile Ala
        355                 360                 365             
Glu Met Glu Thr Glu Ser Trp Ile Val Asp Arg Gln Trp Ala Gln Asp
    370                 375                 380                 
Leu Thr Leu Pro Trp Gln Ser Gly Ser Gly Gly Val Trp Arg Glu Met
385                 390                 395                 400 
His His Leu Val Glu Phe Glu Pro Pro His Ala Ala Thr Ile Arg Val
                405                 410                 415     
Leu Ala Leu Gly Asn Gln Glu Gly Ser Leu Lys Thr Ala Leu Thr Gly
            420                 425                 430         
Ala Met Arg Val Thr Lys Asp Thr Asn Asp Asn Asn Leu Tyr Lys Leu
        435                 440                 445             
His Gly Gly His Val Ser Cys Arg Val Lys Leu Ser Ala Leu Thr Leu
    450                 455                 460                 
Lys Gly Thr Ser Tyr Lys Ile Cys Thr Asp Lys Met Phe Phe Val Lys
465                 470                 475                 480 
Asn Pro Thr Asp Thr Gly His Gly Thr Val Val Met Gln Val Lys Val
                485                 490                 495     
Ser Lys Gly Ala Pro Cys Arg Ile Pro Val Ile Val Ala Asp Asp Leu
            500                 505                 510         
Thr Ala Ala Ile Asn Lys Gly Ile Leu Val Thr Val Asn Pro Ile Ala
        515                 520                 525             
Ser Thr Asn Asp Asp Glu Val Leu Ile Glu Val Asn Pro Pro Phe Gly
    530                 535                 540                 
Asp Ser Tyr Ile Ile Val Gly Arg Gly Asp Ser Arg Leu Thr Tyr Gln
545                 550                 555                 560 
Trp His Lys Glu Gly Ser Ser Ile Gly Lys Leu Phe Thr Gln Thr Met
                565                 570                 575     
Lys Gly Val Glu Arg Leu Ala Val Met Gly Asp Thr Ala Trp Asp Phe
            580                 585                 590         
Ser Ser Ala Gly Gly Phe Phe Thr Ser Val Gly Lys Gly Ile His Thr
        595                 600                 605             
Val Phe Gly Ser Ala Phe Gln Gly Leu Phe Gly Gly Leu Asn Trp Ile
    610                 615                 620                 
Thr Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr
625                 630                 635                 640 
Arg Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met
                645                 650                 655     
Met Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn
            660                 665                 670         
Phe Gly Lys Arg Glu Leu
        675             

