
                                SEQUENCE LISTING

<110> Glaxo Group Limited
      Caroline J DIMECH
      Adriaan Allart STOOP
      Rudolf Maria DE WILDT
      Steve HOLMES

<120> LIGANDS THAT BIND TGF-BETA RECEPTOR RII
  

<130> DB63509 WO

<150> 61/229334           
<151> 2009-07-29  

<160> 123

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-33
      

<400> 1
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ala Pro Ser Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys His Arg Thr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 2
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-251
      

<400> 2
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Lys Ile Thr Gln Lys Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Ala Thr His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 3
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262
      

<400> 3
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Asn Tyr
            20                  25                  30          
Glu Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Ala Glu Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 4
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271
      

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gln Ile Pro Gly His Lys Trp Thr Ala Asn Ser Arg Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 5
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-348
      

<400> 5
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Asp Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Arg Ile Ser His Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg Ser Trp Asp Gly Val His Ala Gln Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 6
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-435
      

<400> 6
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Asp
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Pro Gln Gly Gln His Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys His Asn Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 7
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-436
      

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Lys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Trp Pro Asn Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp His Met Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 8
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437
      

<400> 8
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 9
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-438
      

<400> 9
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gln Gly
            20                  25                  30          
Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Arg Ile Gly Met Asp Gly Asp Lys Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Pro Ser Ser Thr Ser Pro Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 10
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439
      

<400> 10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu
            20                  25                  30          
Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 11
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-440
      

<400> 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Asp
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Pro Gln Gly Gln His Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Leu Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 12
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-6
      

<400> 12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Asn Tyr
            20                  25                  30          
Glu Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Ala Glu Gly Thr Arg Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp
            100                 105                 110         
His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 13
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-10
      

<400> 13
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Asn Tyr
            20                  25                  30          
Glu Met Ala Trp Ala Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Ser Ala Asp Gly Thr Arg Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp
            100                 105                 110         
Tyr Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 14
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-3
      

<400> 14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Glu Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gln Ile Pro Gly His Met Trp Thr Ala Asn Pro Arg Ser Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 


<210> 15
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-7
      

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gln Ile Pro Gly Arg Lys Trp Thr Ala Asn Ser Arg Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 16
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-12
      

<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Glu Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Leu Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gln Ile Pro Gly His Met Trp Thr Ala Asn Pro Arg Ser Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 


<210> 17
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-13
      

<400> 17
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gln Ile Pro Gly Arg Lys Trp Thr Ala Asn Ser Arg Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 18
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-4
      

<400> 18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 19
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-6
      

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 20
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-8
      

<400> 20
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 21
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-9
      

<400> 21
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Tyr Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 22
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-6
      

<400> 22
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu
            20                  25                  30          
Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 23
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-8
      

<400> 23
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu
            20                  25                  30          
Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asn Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 24
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-33
      

<400> 24
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg cagtatcgga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgcgcctt ctggtgataa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatcgg 300
acttcgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 25
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-251
      

<400> 25
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg gattatgata tgtggtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaaag attacgcaga agggtgattt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatgct 300
actcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 26
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-262
      

<400> 26
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttttt aattatgaga tggcgtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattg attagtgctg agggtacgag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc aaaacggcgg 300
gatgctagta tgggtcatac tactcggcgg tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gc                                                     372

<210> 27
<211> 373
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-271
      

<400> 27
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg gagtatagga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgagccga ttggtaatcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacagatt 300
ccggggcata agtggactgc taattcgcgg tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gcg                                                    373

<210> 28
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-348
      

<400> 28
gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gattatgata tggcgtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt atttctcata gtggttattc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgttcg 300
tgggatgggg ttcatgcgca gtttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc                                                               363

<210> 29
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-435
      

<400> 29
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
acctgtgcag cctccggatt cacctttacg gatgatagga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attgatcctc agggtcagca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacataat 300
tcgagttttg actactgggg tcagggaacc ctggtcaccg tctcgagcg             349

<210> 30
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-436
      

<400> 30
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gattataaga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt atttggccta atggtggttt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcat 300
atgggttttg actactgggg tcagggaacc ctggtcaccg tctcgagcg             349

<210> 31
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-437
      

<400> 31
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gattatcgta tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgattctc agggtcatac gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatggg 300
ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagcg             349

<210> 32
<211> 358
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-438
      

<400> 32
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg cagggggata tgtggtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcacgt attggtatgg atggtgataa gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcct 300
tcgagtacta gtccgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagcg   358

<210> 33
<211> 367
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-439
      

<400> 33
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg acggagcaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgattcgc ctggtgggag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacggcat 300
gcggctgggg tttcgggtac ttattttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagcg                                                           367

<210> 34
<211> 349
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-440
      

<400> 34
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg gatgatagga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attgatcctc agggtcagca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300
cttagttttg actactgggg tcagggaacc ctggtcaccg tctcgagcg             349

<210> 35
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-262-6
      

<400> 35
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttttt aattatgaga tggcgtgggc ccgccaggct 120
ccagggaagg gcctagagtg ggtctcattg attagtgctg agggtacgag gacatactac 180
gcaaactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc aaaacggcgg 300
gatgctagta tgggtcatac tactcggcgg tttgaccact ggggtcaggg aaccctggtc 360
accgtctcga gc                                                     372

<210> 36
<211> 371
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-262-10
      

<400> 36
gaggtgcagc tgttggagtc tgggggaggc ttagtacagc ccggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttttt aattatgaga tggcgtgggc ccgccgggct 120
ccagggaagg gtctagagtg ggtctcattg attagtgctg atggtacgag gacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa ccgctgtatc 240
tgcaaatgaa cagcctgcgt gccgaggaca ccgcggtata ttactgtgca aaacggcggg 300
atgctagtat gggtcatact actcggcggt ttgactactc gggtcaggga accctggtca 360
ccgtctcgag c                                                      371

<210> 37
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-271-3
      

<400> 37
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcacag cctccggatt cacctttacg gagtatagga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattg attgagccga ttggtaatcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgctgaggat accgcggtat attactgtgc gaaacagatt 300
ccggggcata tgtggactgc taatccgcgg tctgactact ggggtcaggg aacccaggtc 360
accgtctcga gc                                                     372

<210> 38
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-271-7
      

<400> 38
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg gagtatagga tgtggtgggt ccgccaggct 120
ccggggaagg gtctcgagtg ggtctcagcg attgagccga ttggtaatcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacagatt 300
ccggggcgta agtggactgc taattcgcgg tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gc                                                     372

<210> 39
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-271-12
      

<400> 39
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcacag cctccggatt cacctttacg gagtatagga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattg attgagccga ttggtaatcg tacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgctgaggat accgcggtat attactgtgc gaaacagatt 300
ccggggcata tgtggactgc taatccgcgg tctgactact ggggtcaggg aacccaggtc 360
accgtctcga gc                                                     372

<210> 40
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-271-13
      

<400> 40
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg gagtatagga tgtggtgggt ccgccaggct 120
ccggggaagg gtctcgagtg ggtctcagcg attgagccga ttggtaatcg tacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacagatt 300
ccggggcgta agtggactgc taattcgcgg tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gc                                                     372

<210> 41
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-437-4
      

<400> 41
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccatttct gattatcgta tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgattctc agggtcatac gacatactac 180
gcagactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatggg 300
ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 42
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-437-6
      

<400> 42
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcaa cctccggatt caccttttct gattatcgta tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgattctc agggtcatac gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg cgccgaggat accgcggtat attactgtgc gaaatatggg 300
ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 43
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-437-8
      

<400> 43
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccatttct gattatcgta tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgattctc agggtcatac gacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatggg 300
ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 44
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-437-9
      

<400> 44
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcaa cctccggatt caccttttct gattatcgta tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgattctc agggtcatac gacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg cgccgaggat accgcggtat attactgtgc gaaatatggg 300
ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc              348

<210> 45
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-439-6
      

<400> 45
gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg acggagcaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacga attgattcac ctggtgggag gacatactac 180
gcagactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacggcat 300
gcggctgggg tttcgggtac ttattttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc                                                            366

<210> 46
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> DOM23h-439-8
      

<400> 46
gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg acggagcaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacga attgattcac ctggtgggag gacatactac 180
gcaaactccg tgaggggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacggcat 300
gcggctgggg tttcgggtac ttattttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc                                                            366

<210> 47
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 47
Thr Thr Gly Cys Ala Gly Gly Cys Gly Thr Gly Gly Cys Ala Ala Cys
 1               5                  10                  15      
Ala Gly Cys Gly
            20  


<210> 48
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 48
Cys Ala Cys Gly Ala Cys Gly Thr Thr Gly Thr Ala Ala Ala Ala Cys
 1               5                  10                  15      
Gly Ala Cys Gly Gly Cys Cys
            20              


<210> 49
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 49
Ala Gly Cys Gly Gly Ala Thr Ala Ala Cys Ala Ala Thr Thr Thr Cys
 1               5                  10                  15      
Ala Cys Ala Cys Ala Gly Gly Ala
            20                  


<210> 50
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 50
Cys Gly Cys Cys Ala Gly Gly Gly Thr Thr Thr Thr Cys Cys Cys Ala
 1               5                  10                  15      
Gly Thr Cys Ala Cys Gly Ala Cys
            20                  


<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 51
Thr Thr Gly Cys Ala Gly Gly Cys Gly Thr Gly Gly Cys Ala Ala Cys
 1               5                  10                  15      
Ala Gly Cys Gly
            20  


<210> 52
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 52
Cys Ala Cys Gly Ala Cys Gly Thr Thr Gly Thr Ala Ala Ala Ala Cys
 1               5                  10                  15      
Gly Ala Cys Gly Gly Cys Cys
            20              


<210> 53
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 53
Gly Ala Ala Cys Cys Gly Gly Cys Cys Cys Cys Thr Cys Ala Cys Gly
 1               5                  10                  15      
Gly Ala Gly Thr Thr Thr Gly Cys Gly Thr Ala Gly Thr Ala
            20                  25                  30  


<210> 54
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> primer

<400> 54
Thr Ala Cys Thr Ala Cys Gly Cys Ala Ala Ala Cys Thr Cys Cys Gly
 1               5                  10                  15      
Thr Gly Ala Gly Gly Gly Gly Cys Cys Gly Gly Thr Thr Cys
            20                  25                  30  


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-33 CDR1
      

<400> 55
Gln Tyr Arg Met Trp
 1               5  


<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-33 CDR2
      

<400> 56
Ala Ile Ala Pro Ser Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-33 CDR3
      

<400> 57
His Arg Thr Ser Phe Asp Tyr
 1               5          


<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-251 CDR1
      

<400> 58
Asp Tyr Asp Met Trp
 1               5  


<210> 59
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-251 CDR2
      

<400> 59
Lys Ile Thr Gln Lys Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-251 CDR3
      

<400> 60
Asp Ala Thr His Phe Asp Tyr
 1               5          


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262 CDR1
      

<400> 61
Asn Tyr Glu Met Ala
 1               5  


<210> 62
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262 CDR2
      

<400> 62
Leu Ile Ser Ala Glu Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262 CDR3
      

<400> 63
Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp Tyr
 1               5                  10                  15  


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271 CDR1
      

<400> 64
Glu Tyr Arg Met Trp
 1               5  


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271 CDR2
      

<400> 65
Ser Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271 CDR3
      

<400> 66
Gln Ile Pro Gly His Lys Trp Thr Ala Asn Ser Arg Phe Asp Tyr
 1               5                  10                  15  


<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-348 CDR1
      

<400> 67
Asp Tyr Asp Met Ala
 1               5  


<210> 68
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-348 CDR2
      

<400> 68
Arg Ile Ser His Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-348 CDR3
      

<400> 69
Arg Ser Trp Asp Gly Val His Ala Gln Phe Asp Tyr Trp
 1               5                  10              


<210> 70
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-435 CDR1
      

<400> 70
Asp Asp Arg Met Trp
 1               5  


<210> 71
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-435 CDR2
      

<400> 71
Ala Ile Asp Pro Gln Gly Gln His Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-435 CDR3
      

<400> 72
His Asn Ser Ser Phe Asp Tyr Trp
 1               5              


<210> 73
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-436 CDR1
      
      

<400> 73
Asp Tyr Lys Met Gly
 1               5  


<210> 74
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-436 CDR2
      
      

<400> 74
Ser Ile Trp Pro Asn Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 75
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-436 CDR3
      
      
      

<400> 75
Asp His Met Gly Phe Asp Tyr Trp
 1               5              


<210> 76
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437 CDR1
      
      

<400> 76
Asp Tyr Arg Met Trp
 1               5  


<210> 77
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437 CDR2
      
      

<400> 77
Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 78
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437 CDR3
      

<400> 78
Tyr Gly Gly Tyr Phe Asp Tyr Trp
 1               5              


<210> 79
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-438 CDR1
      

<400> 79
Gln Gly Asp Met Trp
 1               5  


<210> 80
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-438 CDR2
      

<400> 80
Arg Ile Gly Met Asp Gly Asp Lys Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-438 CDR3
      

<400> 81
Gly Pro Ser Ser Thr Ser Pro Phe Asp Tyr
 1               5                  10  


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439 CDR1
      

<400> 82
Thr Glu Gln Met Trp
 1               5  


<210> 83
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439 CDR2
      

<400> 83
Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 84
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439 CDR3
      

<400> 84
Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr
 1               5                  10              


<210> 85
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-440 CDR1
      

<400> 85
Asp Asp Arg Met Trp
 1               5  


<210> 86
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-440 CDR2
      
      

<400> 86
Ala Ile Asp Pro Gln Gly Gln His Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-440 CDR3
      
      

<400> 87
Glu Leu Leu Ser Phe Asp Tyr Trp
 1               5              


<210> 88
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-6 CDR1
      

<400> 88
Asn Tyr Glu Met Ala Trp
 1               5      


<210> 89
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-6 CDR2
      

<400> 89
Leu Ile Ser Ala Glu Gly Thr Arg Thr Tyr Tyr Ala Asn Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 90
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-6 CDR3
      

<400> 90
Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp His
 1               5                  10                  15  


<210> 91
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-10 CDR1
      

<400> 91
Phe Asn Tyr Glu Met Ala
 1               5      


<210> 92
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-10 CDR2
      

<400> 92
Leu Ile Ser Ala Asp Gly Thr Arg Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 93
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-262-10 CDR3
      

<400> 93
Arg Arg Asp Ala Ser Met Gly His Thr Thr Arg Arg Phe Asp Tyr
 1               5                  10                  15  


<210> 94
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-3 CDR1
      

<400> 94
Glu Tyr Arg Met Trp
 1               5  


<210> 95
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-3 CDR2
      

<400> 95
Leu Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 96
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-3 CDR3
      

<400> 96
Gln Ile Pro Gly His Met Trp Thr Ala Asn Pro Arg Ser Asp Tyr
 1               5                  10                  15  


<210> 97
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-7 CDR1
      

<400> 97
Glu Tyr Arg Met Trp
 1               5  


<210> 98
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-7 CDR2
      

<400> 98
Ala Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 99
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-7 CDR3
      

<400> 99
Gln Ile Pro Gly Arg Lys Trp Thr Ala Asn Ser Arg Phe Asp Tyr
 1               5                  10                  15  


<210> 100
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-12 CDR1
      

<400> 100
Glu Tyr Arg Met Trp
 1               5  


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-12 CDR2
      

<400> 101
Leu Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 102
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-12 CDR3
      

<400> 102
Gln Ile Pro Gly His Met Trp Thr Ala Asn Pro Arg Ser Asp Tyr
 1               5                  10                  15  


<210> 103
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-13 CDR1
      

<400> 103
Glu Tyr Arg Met Trp
 1               5  


<210> 104
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-13 CDR2
      

<400> 104
Ala Ile Glu Pro Ile Gly Asn Arg Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 105
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-271-13 CDR3
      

<400> 105
Gln Ile Pro Gly Arg Lys Trp Thr Ala Asn Ser Arg Phe Asp Tyr
 1               5                  10                  15  


<210> 106
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-4 CDR1
      

<400> 106
Asp Tyr Arg Met Trp
 1               5  


<210> 107
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-4 CDR2
      

<400> 107
Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 108
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-4 CDR3
      

<400> 108
Tyr Gly Gly Tyr Phe Asp Tyr
 1               5          


<210> 109
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-6 CDR1
      

<400> 109
Asp Tyr Arg Met Trp
 1               5  


<210> 110
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-6 CDR2
      

<400> 110
Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 111
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-6 CDR3
      

<400> 111
Tyr Gly Gly Tyr Phe Asp Tyr
 1               5          


<210> 112
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-8 CDR1
      

<400> 112
Asp Tyr Arg Met Trp
 1               5  


<210> 113
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-8 CDR2
      

<400> 113
Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 114
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-8 CDR3
      

<400> 114
Tyr Gly Gly Tyr Phe Asp Tyr
 1               5          


<210> 115
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-9 CDR1
      

<400> 115
Ser Asp Tyr Arg Met
 1               5  


<210> 116
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-9 CDR2
      

<400> 116
Ala Ile Asp Ser Gln Gly His Thr Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 117
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-437-9 CDR3
      

<400> 117
Tyr Gly Gly Tyr Phe Asp Tyr
 1               5          


<210> 118
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-6 CDR1
      

<400> 118
Thr Glu Gln Met Trp
 1               5  


<210> 119
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-6 CDR2
      

<400> 119
Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 120
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-6 CDR3
      

<400> 120
Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr
 1               5                  10              


<210> 121
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-8 CDR1
      

<400> 121
Thr Glu Gln Met Trp
 1               5  


<210> 122
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-8 CDR2
      

<400> 122
Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asn Ser Val Arg
 1               5                  10                  15      
Gly
    


<210> 123
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> DOM23h-439-8 CDR3
      

<400> 123
Arg His Ala Ala Gly Val Ser Gly Thr Tyr Phe Asp Tyr
 1               5                  10              

