                         SEQUENCE LISTING

<110>  ENZON PHARMACEUTICALS, INC.
       SAPRA, Puja
 
<120>  METHODS OF TREATING HER2 POSITIVE CANCER WITH HER2 RECEPTOR 
       ANTAGONIST IN COMBINATION WITH MULTI-ARM POLYMERIC CONJUGATES OF 
       7-ETHYL-10-HYDROXYCAMPTOTHECIN

<130>  213.1337-PCT

<140>  To be assigned
<141>  2010-07-21

<150>  61/227,599
<151>  2009-07-22

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4473
<212>  DNA
<213>  Human


<220>
<221>  CDS
<222>  (175)..(3942)

<400>  1
aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca       60

cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc      120

gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag cacc atg        177
                                                            Met           
                                                            1             

gag ctg gcg gcc ttg tgc cgc tgg ggg ctc ctc ctc gcc ctc ttg ccc        225
Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu Pro           
            5                   10                  15                    

ccc gga gcc gcg agc acc caa gtg tgc acc ggc aca gac atg aag ctg        273
Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu           
        20                  25                  30                        

cgg ctc cct gcc agt ccc gag acc cac ctg gac atg ctc cgc cac ctc        321
Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His Leu           
    35                  40                  45                            

tac cag ggc tgc cag gtg gtg cag gga aac ctg gaa ctc acc tac ctg        369
Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu           
50                  55                  60                  65            

ccc acc aat gcc agc ctg tcc ttc ctg cag gat atc cag gag gtg cag        417
Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln           
                70                  75                  80                

ggc tac gtg ctc atc gct cac aac caa gtg agg cag gtc cca ctg cag        465
Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln           
            85                  90                  95                    

agg ctg cgg att gtg cga ggc acc cag ctc ttt gag gac aac tat gcc        513
Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala           
        100                 105                 110                       

ctg gcc gtg cta gac aat gga gac ccg ctg aac aat acc acc cct gtc        561
Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val           
    115                 120                 125                           

aca ggg gcc tcc cca gga ggc ctg cgg gag ctg cag ctt cga agc ctc        609
Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu           
130                 135                 140                 145           

aca gag atc ttg aaa gga ggg gtc ttg atc cag cgg aac ccc cag ctc        657
Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu           
                150                 155                 160               

tgc tac cag gac acg att ttg tgg aag gac atc ttc cac aag aac aac        705
Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn           
            165                 170                 175                   

cag ctg gct ctc aca ctg ata gac acc aac cgc tct cgg gcc tgc cac        753
Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His           
        180                 185                 190                       

ccc tgt tct ccg atg tgt aag ggc tcc cgc tgc tgg gga gag agt tct        801
Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser           
    195                 200                 205                           

gag gat tgt cag agc ctg acg cgc act gtc tgt gcc ggt ggc tgt gcc        849
Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala           
210                 215                 220                 225           

cgc tgc aag ggg cca ctg ccc act gac tgc tgc cat gag cag tgt gct        897
Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala           
                230                 235                 240               

gcc ggc tgc acg ggc ccc aag cac tct gac tgc ctg gcc tgc ctc cac        945
Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His           
            245                 250                 255                   

ttc aac cac agt ggc atc tgt gag ctg cac tgc cca gcc ctg gtc acc        993
Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr           
        260                 265                 270                       

tac aac aca gac acg ttt gag tcc atg ccc aat ccc gag ggc cgg tat       1041
Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr           
    275                 280                 285                           

aca ttc ggc gcc agc tgt gtg act gcc tgt ccc tac aac tac ctt tct       1089
Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser           
290                 295                 300                 305           

acg gac gtg gga tcc tgc acc ctc gtc tgc ccc ctg cac aac caa gag       1137
Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu           
                310                 315                 320               

gtg aca gca gag gat gga aca cag cgg tgt gag aag tgc agc aag ccc       1185
Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro           
            325                 330                 335                   

tgt gcc cga gtg tgc tat ggt ctg ggc atg gag cac ttg cga gag gtg       1233
Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val           
        340                 345                 350                       

agg gca gtt acc agt gcc aat atc cag gag ttt gct ggc tgc aag aag       1281
Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys           
    355                 360                 365                           

atc ttt ggg agc ctg gca ttt ctg ccg gag agc ttt gat ggg gac cca       1329
Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro           
370                 375                 380                 385           

gcc tcc aac act gcc ccg ctc cag cca gag cag ctc caa gtg ttt gag       1377
Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu           
                390                 395                 400               

act ctg gaa gag atc aca ggt tac cta tac atc tca gca tgg ccg gac       1425
Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp           
            405                 410                 415                   

agc ctg cct gac ctc agc gtc ttc cag aac ctg caa gta atc cgg gga       1473
Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly           
        420                 425                 430                       

cga att ctg cac aat ggc gcc tac tcg ctg acc ctg caa ggg ctg ggc       1521
Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly           
    435                 440                 445                           

atc agc tgg ctg ggg ctg cgc tca ctg agg gaa ctg ggc agt gga ctg       1569
Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu           
450                 455                 460                 465           

gcc ctc atc cac cat aac acc cac ctc tgc ttc gtg cac acg gtg ccc       1617
Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val Pro           
                470                 475                 480               

tgg gac cag ctc ttt cgg aac ccg cac caa gct ctg ctc cac act gcc       1665
Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala           
            485                 490                 495                   

aac cgg cca gag gac gag tgt gtg ggc gag ggc ctg gcc tgc cac cag       1713
Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln           
        500                 505                 510                       

ctg tgc gcc cga ggg cac tgc tgg ggt cca ggg ccc acc cag tgt gtc       1761
Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val           
    515                 520                 525                           

aac tgc agc cag ttc ctt cgg ggc cag gag tgc gtg gag gaa tgc cga       1809
Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg           
530                 535                 540                 545           

gta ctg cag ggg ctc ccc agg gag tat gtg aat gcc agg cac tgt ttg       1857
Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu           
                550                 555                 560               

ccg tgc cac cct gag tgt cag ccc cag aat ggc tca gtg acc tgt ttt       1905
Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe           
            565                 570                 575                   

gga ccg gag gct gac cag tgt gtg gcc tgt gcc cac tat aag gac cct       1953
Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro           
        580                 585                 590                       

ccc ttc tgc gtg gcc cgc tgc ccc agc ggt gtg aaa cct gac ctc tcc       2001
Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser           
    595                 600                 605                           

tac atg ccc atc tgg aag ttt cca gat gag gag ggc gca tgc cag cct       2049
Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro           
610                 615                 620                 625           

tgc ccc atc aac tgc acc cac tcc tgt gtg gac ctg gat gac aag ggc       2097
Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly           
                630                 635                 640               

tgc ccc gcc gag cag aga gcc agc cct ctg acg tcc atc atc tct gcg       2145
Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala           
            645                 650                 655                   

gtg gtt ggc att ctg ctg gtc gtg gtc ttg ggg gtg gtc ttt ggg atc       2193
Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile           
        660                 665                 670                       

ctc atc aag cga cgg cag cag aag atc cgg aag tac acg atg cgg aga       2241
Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg           
    675                 680                 685                           

ctg ctg cag gaa acg gag ctg gtg gag ccg ctg aca cct agc gga gcg       2289
Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala           
690                 695                 700                 705           

atg ccc aac cag gcg cag atg cgg atc ctg aaa gag acg gag ctg agg       2337
Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg           
                710                 715                 720               

aag gtg aag gtg ctt gga tct ggc gct ttt ggc aca gtc tac aag ggc       2385
Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly           
            725                 730                 735                   

atc tgg atc cct gat ggg gag aat gtg aaa att cca gtg gcc atc aaa       2433
Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys           
        740                 745                 750                       

gtg ttg agg gaa aac aca tcc ccc aaa gcc aac aaa gaa atc tta gac       2481
Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp           
    755                 760                 765                           

gaa gca tac gtg atg gct ggt gtg ggc tcc cca tat gtc tcc cgc ctt       2529
Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu           
770                 775                 780                 785           

ctg ggc atc tgc ctg aca tcc acg gtg cag ctg gtg aca cag ctt atg       2577
Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met           
                790                 795                 800               

ccc tat ggc tgc ctc tta gac cat gtc cgg gaa aac cgc gga cgc ctg       2625
Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu           
            805                 810                 815                   

ggc tcc cag gac ctg ctg aac tgg tgt atg cag att gcc aag ggg atg       2673
Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met           
        820                 825                 830                       

agc tac ctg gag gat gtg cgg ctc gta cac agg gac ttg gcc gct cgg       2721
Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg           
    835                 840                 845                           

aac gtg ctg gtc aag agt ccc aac cat gtc aaa att aca gac ttc ggg       2769
Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly           
850                 855                 860                 865           

ctg gct cgg ctg ctg gac att gac gag aca gag tac cat gca gat ggg       2817
Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly           
                870                 875                 880               

ggc aag gtg ccc atc aag tgg atg gcg ctg gag tcc att ctc cgc cgg       2865
Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg           
            885                 890                 895                   

cgg ttc acc cac cag agt gat gtg tgg agt tat ggt gtg act gtg tgg       2913
Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp           
        900                 905                 910                       

gag ctg atg act ttt ggg gcc aaa cct tac gat ggg atc cca gcc cgg       2961
Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg           
    915                 920                 925                           

gag atc cct gac ctg ctg gaa aag ggg gag cgg ctg ccc cag ccc ccc       3009
Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro           
930                 935                 940                 945           

atc tgc acc att gat gtc tac atg atc atg gtc aaa tgt tgg atg att       3057
Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile           
                950                 955                 960               

gac tct gaa tgt cgg cca aga ttc cgg gag ttg gtg tct gaa ttc tcc       3105
Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser           
            965                 970                 975                   

cgc atg gcc agg gac ccc cag cgc ttt gtg gtc atc cag aat gag gac       3153
Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp           
        980                 985                 990                       

ttg ggc cca gcc agt ccc ttg  gac agc acc ttc tac  cgc tca ctg ctg     3201
Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu Leu         
    995                 1000                 1005                         

gag  gac gat gac atg ggg  gac ctg gtg gat gct  gag gag tat ctg        3246
Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr Leu            
1010                 1015                 1020                            

gta  ccc cag cag ggc ttc  ttc tgt cca gac cct  gcc ccg ggc gct        3291
Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly Ala            
1025                 1030                 1035                            

ggg  ggc atg gtc cac cac  agg cac cgc agc tca  tct acc agg agt        3336
Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg Ser            
1040                 1045                 1050                            

ggc  ggt ggg gac ctg aca  cta ggg ctg gag ccc  tct gaa gag gag        3381
Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu Glu            
1055                 1060                 1065                            

gcc  ccc agg tct cca ctg  gca ccc tcc gaa ggg  gct ggc tcc gat        3426
Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser Asp            
1070                 1075                 1080                            

gta  ttt gat ggt gac ctg  gga atg ggg gca gcc  aag ggg ctg caa        3471
Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu Gln            
1085                 1090                 1095                            

agc  ctc ccc aca cat gac  ccc agc cct cta cag  cgg tac agt gag        3516
Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser Glu            
1100                 1105                 1110                            

gac  ccc aca gta ccc ctg  ccc tct gag act gat  ggc tac gtt gcc        3561
Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val Ala            
1115                 1120                 1125                            

ccc  ctg acc tgc agc ccc  cag cct gaa tat gtg  aac cag cca gat        3606
Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro Asp            
1130                 1135                 1140                            

gtt  cgg ccc cag ccc cct  tcg ccc cga gag ggc  cct ctg cct gct        3651
Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro Ala            
1145                 1150                 1155                            

gcc  cga cct gct ggt gcc  act ctg gaa agg ccc  aag act ctc tcc        3696
Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu Ser            
1160                 1165                 1170                            

cca  ggg aag aat ggg gtc  gtc aaa gac gtt ttt  gcc ttt ggg ggt        3741
Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly Gly            
1175                 1180                 1185                            

gcc  gtg gag aac ccc gag  tac ttg aca ccc cag  gga gga gct gcc        3786
Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala Ala            
1190                 1195                 1200                            

cct  cag ccc cac cct cct  cct gcc ttc agc cca  gcc ttc gac aac        3831
Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp Asn            
1205                 1210                 1215                            

ctc  tat tac tgg gac cag  gac cca cca gag cgg  ggg gct cca ccc        3876
Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro Pro            
1220                 1225                 1230                            

agc  acc ttc aaa ggg aca  cct acg gca gag aac  cca gag tac ctg        3921
Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr Leu            
1235                 1240                 1245                            

ggt  ctg gac gtg cca gtg  tga accagaaggc caagtccgca gaagccctga        3972
Gly  Leu Asp Val Pro Val                                                  
1250                 1255                                                 

tgtgtcctca gggagcaggg aaggcctgac ttctgctggc atcaagaggt gggagggccc     4032

tccgaccact tccaggggaa cctgccatgc caggaacctg tcctaaggaa ccttccttcc     4092

tgcttgagtt cccagatggc tggaaggggt ccagcctcgt tggaagagga acagcactgg     4152

ggagtctttg tggattctga ggccctgccc aatgagactc tagggtccag tggatgccac     4212

agcccagctt ggccctttcc ttccagatcc tgggtactga aagccttagg gaagctggcc     4272

tgagagggga agcggcccta agggagtgtc taagaacaaa agcgacccat tcagagactg     4332

tccctgaaac ctagtactgc cccccatgag gaaggaacag caatggtgtc agtatccagg     4392

ctttgtacag agtgcttttc tgtttagttt ttactttttt tgttttgttt ttttaaagat     4452

gaaataaaga cccaggggga g                                               4473


<210>  2
<211>  1255
<212>  PRT
<213>  Human

<400>  2

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


