                         SEQUENCE LISTING

<110>  Constellation Pharmaceuticals
       Trojer, Patrick
       Lan, Fei
 
<120>  Agents for Stimulating Activity of Methyl Modifying Enzymes and 
       Methods of Use Thereof

<130>  2009052-0010

<140>  PCT/US2010/042527
<141>  2010-07-20

<150>  61/227,031
<151>  2009-07-20

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr 
            20                  25                  30          


Gly Glu Ser Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Ala Ala Leu 
        35                  40                  45              


Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu 
    50                  55                  60  


<210>  2
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys 
1               5                   10                  15      


Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys Pro 
            20                  25                  30          


Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly 
        35                  40                  45              


Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val 
    50                  55                  60  


<210>  3
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu Lys 
1               5                   10                  15      


Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys Arg 
            20                  25                  30          


Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val Ala 
        35                  40                  45              


Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala 
    50                  55                  60  


<210>  4
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu Lys 
1               5                   10                  15      


Thr Pro Val Lys Lys Lys Ala Arg Lys Ala Ala Gly Gly Ala Lys Arg 
            20                  25                  30          


Lys Thr Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val Ala 
        35                  40                  45              


Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala 
    50                  55                  60  


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  DIMETHYLATION

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  BIOTINYLATION

<400>  5

Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys Arg Lys Ala 
1               5                   10                  15      


Ser Gly 
        


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Ala Arg Thr Lys 
1               


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Ala Arg Thr Lys Gln 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Ala Arg Thr Lys Gln Thr 
1               5       


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Ala Arg Thr Lys Gln Thr Ala 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Ala Arg Thr Lys Gln Thr Ala Arg 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Ala Arg Thr Lys Gln Thr Ala Arg Lys 
1               5                   


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Arg Thr Lys Gln 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Arg Thr Lys Gln Thr 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Thr Lys Gln Thr 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Lys Gln Thr Ala 
1               


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  TRIMETHYLATION

<400>  16

Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr 
1               5                   10                  15      


Gly Gly Val Lys Lys Pro 
            20          


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  TRIMETHYLATION

<400>  17

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  TRIMETHYLATION

<400>  18

Leu Gly Lys Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg Asp Asn 
1               5                   10                  15      


Ile Gln Gly Ile Thr 
            20      


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  DIMETHYLATION

<400>  19

Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys Arg Lys Ala 
1               5                   10                  15      


Ser Gly 
        


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  TRIMETHYLATION

<400>  20

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  TRIMETHYLATiON

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  TRIMETHYLATiON

<400>  21

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  22
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  TRIMETHYLATION

<400>  22

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  TRIMETHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  TRIMETHYLATION

<400>  23

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  24
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  DIMETHYLATION

<400>  24

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  TRIMETHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  DIMETHYLATION

<400>  25

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  TRIMETHYLATION

<400>  26

Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr 
1               5                   10                  15      


Gly Gly Val Lys Lys Pro 
            20          


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  TRIMETHYLATION

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  BIOTINYLATION

<400>  27

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Arg Lys Gln Leu Ala 
            20      


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  TRIMETHYLATION

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  BIOTINYLATION

<400>  28

Leu Gly Lys Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg Asp Asn 
1               5                   10                  15      


Ile Gln Gly Ile Thr 
            20      


