                         SEQUENCE LISTING

<110>  ABBAS, ALEXANDER R.
       CLARK, HILARY
       DIEHL, LAURI
       LEES, CHARLES
       NOBLE, COLIN L.
       SATSANGI, JACK
 
<120>  GENE EXPRESSION MARKERS FOR CROHN'S DISEASE

<130>  GNE-0353 PCT (P4318R1)

<140>  61/227,049
<141>  2009-07-20

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  3459
<212>  DNA
<213>  Homo sapiens

<400>  1
ctcaatcagc tttatgcaga gaagaagctt actgagctca ctgctggtgc tggtgtaggc       60

aagtgctgct ttggcaatct gggctgacct ggcttgtctc ctcagaactc cttctccaac      120

cctggagcag gcttccatgc tgctgtgggc gtccttgctg gcctttgctc cagtctgtgg      180

acaatctgca gctgcacaca aacctgtgat ttccgtccat cctccatgga ccacattctt      240

caaaggagag agagtgactc tgacttgcaa tggatttcag ttctatgcaa cagagaaaac      300

aacatggtat catcggcact actggggaga aaagttgacc ctgaccccag gaaacaccct      360

cgaggttcgg gaatctggac tgtacagatg ccaggcccgg ggctccccac gaagtaaccc      420

tgtgcgcttg ctcttttctt cagactcctt aatcctgcag gcaccatatt ctgtgtttga      480

aggtgacaca ttggttctga gatgccacag aagaaggaaa gagaaattga ctgctgtgaa      540

atatacttgg aatggaaaca ttctttccat ttctaataaa agctgggatc ttcttatccc      600

acaagcaagt tcaaataaca atggcaatta tcgatgcatt ggatatggag atgagaatga      660

tgtatttaga tcaaatttca aaataattaa aattcaagaa ctatttccac atccagagct      720

gaaagctaca gactctcagc ctacagaggg gaattctgta aacctgagct gtgaaacaca      780

gcttcctcca gagcggtcag acaccccact tcacttcaac ttcttcagag atggcgaggt      840

catcctgtca gactggagca cgtacccgga actccagctc ccaaccgtct ggagagaaaa      900

ctcaggatcc tattggtgtg gtgctgaaac agtgaggggt aacatccaca agcacagtcc      960

ctcgctacag atccatgtgc agcggatccc tgtgtctggg gtgctcctgg agacccagcc     1020

ctcagggggc caggctgttg aaggggagat gctggtcctt gtctgctccg tggctgaagg     1080

cacaggggat accacattct cctggcaccg agaggacatg caggagagtc tggggaggaa     1140

aactcagcgt tccctgagag cagagctgga gctccctgcc atcagacaga gccatgcagg     1200

gggatactac tgtacagcag acaacagcta cggccctgtc cagagcatgg tgctgaatgt     1260

cactgtgaga gagaccccag gcaacagaga tggccttgtc gccgcgggag ccactggagg     1320

gctgctcagt gctcttctcc tggctgtggc cctgctgttt cactgctggc gtcggaggaa     1380

gtcaggagtt ggtttcttgg gagacgaaac caggctccct cccgctccag gcccaggaga     1440

gtcctcccat tccatctgcc ctgcccaggt ggagcttcag tcgttgtatg ttgatgtaca     1500

ccccaaaaag ggagatttgg tatactctga gatccagact actcagctgg gagaagaaga     1560

ggaagctaat acctccagga cacttctaga ggataaggat gtctcagttg tctactctga     1620

ggtaaagaca caacacccag ataactcagc tggaaagatc agctctaagg atgaagaaag     1680

ttaagagaat gaaaagttac gggaacgtcc tactcatgtg atttctccct tgtccaaagt     1740

cccaggccca gtgcagtcct tgcggcacct ggaatgatca actcattcca gctttctaat     1800

tcttctcatg catatgcatt cactcccagg aatactcatt cgtctactct gatgttggga     1860

tggaatggcc tctgaaagac ttcactaaaa tgaccaggat ccacagttaa gagaagaccc     1920

tgtagtattt gctgtgggcc tgacctaatg cattccctag ggtctgcttt agagaagggg     1980

gataaagaga gagaaggact gttatgaaaa acagaagcac aaattttggt gaattgggat     2040

ttgcagagat gaaaaagact gggtgacctg gatctctgct taatacatct acaaccattg     2100

tctcactgga gactcacttg catcagtttg tttaactgtg agtggctgca caggcactgt     2160

gcaaacaatg aaaagcccct tcacttctgc ctgcacagct tacactgtca ggattcagtt     2220

gcagattaaa gaacccatct ggaatggttt acagagagag gaatttaaaa gaggacatca     2280

gaagagctgg agatgcaagc tctaggctgc gcttccaaaa gcaaatgata attatgttaa     2340

tgtcattagt gacaaagatt tgcaacatta gagaaaagag acacaaatat aaaattaaaa     2400

acttaagtac caactctcca aaactaaatt tgaacttaaa atattagtat aaactcataa     2460

taaactctgc ctttaaaaaa agataaatat ttcctacgtc tgttcactga aataattacc     2520

aaccccttag caataagcac tccttgcaga gaggttttat tctctaaata ccattccctt     2580

ctcaaaggaa ataaggttgc ttttcttgta ggaactgtgt ctttgagtta ctaattagtt     2640

tatatgagaa taattcttgc aataaatgaa gaaggaataa aagaaatagg aagccacaaa     2700

tttgtatgga tatttcatga tacacctact ggttaaataa ttgacaaaaa ccagcagcca     2760

aatattagag gtctcctgat ggaagtgtac aataccacct acaaattatc catgccccaa     2820

gtgttaaaac tgaatccatt caagtctttc taactgaata cttgttttat agaaaatgca     2880

tggagaaaag gaatttgttt aaataacatt atgggattgc aaccagcaaa acataaactg     2940

agaaaaagtt ctatagggca aatcacctgg cttctataac aaataaatgg gaaaaaaatg     3000

aaataaaaag aagagaggga ggaagaaagg gagagagaag aaaagaaaaa tgaagaaaag     3060

taattagaat attttcaaca taaagaaaag acgaatattt aaggtgacag atatcccaac     3120

tacgctgatt tgatctttac aaattatatg agtgtatgaa tttgtcacat gtatcacccc     3180

caaaaaaaga gaaaaagaaa aatagaagac atataaatta aatgagacga gacatgtcga     3240

ccaaaaggaa tgtgtgggtc ttgtttggat cctgactcaa attaagaaaa aataaaacta     3300

cctacgaaat actaagaaaa atttgtatac taatattaag aaattgttgt gtgttttgga     3360

tataagtgat agtttattgt agtgatgttt ttataaaagc aaaaggatat tcactttcag     3420

cgcttatact gaagtattag attaaagctt attaacgta                            3459


<210>  2
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Trp Ala Ser Leu Leu Ala Phe Ala Pro Val Cys Gly Gln 
1               5                   10                  15      


Ser Ala Ala Ala His Lys Pro Val Ile Ser Val His Pro Pro Trp Thr 
            20                  25                  30          


Thr Phe Phe Lys Gly Glu Arg Val Thr Leu Thr Cys Asn Gly Phe Gln 
        35                  40                  45              


Phe Tyr Ala Thr Glu Lys Thr Thr Trp Tyr His Arg His Tyr Trp Gly 
    50                  55                  60                  


Glu Lys Leu Thr Leu Thr Pro Gly Asn Thr Leu Glu Val Arg Glu Ser 
65                  70                  75                  80  


Gly Leu Tyr Arg Cys Gln Ala Arg Gly Ser Pro Arg Ser Asn Pro Val 
                85                  90                  95      


Arg Leu Leu Phe Ser Ser Asp Ser Leu Ile Leu Gln Ala Pro Tyr Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Thr Leu Val Leu Arg Cys His Arg Arg Arg Lys 
        115                 120                 125             


Glu Lys Leu Thr Ala Val Lys Tyr Thr Trp Asn Gly Asn Ile Leu Ser 
    130                 135                 140                 


Ile Ser Asn Lys Ser Trp Asp Leu Leu Ile Pro Gln Ala Ser Ser Asn 
145                 150                 155                 160 


Asn Asn Gly Asn Tyr Arg Cys Ile Gly Tyr Gly Asp Glu Asn Asp Val 
                165                 170                 175     


Phe Arg Ser Asn Phe Lys Ile Ile Lys Ile Gln Glu Leu Phe Pro His 
            180                 185                 190         


Pro Glu Leu Lys Ala Thr Asp Ser Gln Pro Thr Glu Gly Asn Ser Val 
        195                 200                 205             


Asn Leu Ser Cys Glu Thr Gln Leu Pro Pro Glu Arg Ser Asp Thr Pro 
    210                 215                 220                 


Leu His Phe Asn Phe Phe Arg Asp Gly Glu Val Ile Leu Ser Asp Trp 
225                 230                 235                 240 


Ser Thr Tyr Pro Glu Leu Gln Leu Pro Thr Val Trp Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Tyr Trp Cys Gly Ala Glu Thr Val Arg Gly Asn Ile His Lys 
            260                 265                 270         


His Ser Pro Ser Leu Gln Ile His Val Gln Arg Ile Pro Val Ser Gly 
        275                 280                 285             


Val Leu Leu Glu Thr Gln Pro Ser Gly Gly Gln Ala Val Glu Gly Glu 
    290                 295                 300                 


Met Leu Val Leu Val Cys Ser Val Ala Glu Gly Thr Gly Asp Thr Thr 
305                 310                 315                 320 


Phe Ser Trp His Arg Glu Asp Met Gln Glu Ser Leu Gly Arg Lys Thr 
                325                 330                 335     


Gln Arg Ser Leu Arg Ala Glu Leu Glu Leu Pro Ala Ile Arg Gln Ser 
            340                 345                 350         


His Ala Gly Gly Tyr Tyr Cys Thr Ala Asp Asn Ser Tyr Gly Pro Val 
        355                 360                 365             


Gln Ser Met Val Leu Asn Val Thr Val Arg Glu Thr Pro Gly Asn Arg 
    370                 375                 380                 


Asp Gly Leu Val Ala Ala Gly Ala Thr Gly Gly Leu Leu Ser Ala Leu 
385                 390                 395                 400 


Leu Leu Ala Val Ala Leu Leu Phe His Cys Trp Arg Arg Arg Lys Ser 
                405                 410                 415     


Gly Val Gly Phe Leu Gly Asp Glu Thr Arg Leu Pro Pro Ala Pro Gly 
            420                 425                 430         


Pro Gly Glu Ser Ser His Ser Ile Cys Pro Ala Gln Val Glu Leu Gln 
        435                 440                 445             


Ser Leu Tyr Val Asp Val His Pro Lys Lys Gly Asp Leu Val Tyr Ser 
    450                 455                 460                 


Glu Ile Gln Thr Thr Gln Leu Gly Glu Glu Glu Glu Ala Asn Thr Ser 
465                 470                 475                 480 


Arg Thr Leu Leu Glu Asp Lys Asp Val Ser Val Val Tyr Ser Glu Val 
                485                 490                 495     


Lys Thr Gln His Pro Asp Asn Ser Ala Gly Lys Ile Ser Ser Lys Asp 
            500                 505                 510         


Glu Glu Ser 
        515 


<210>  3
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  3
ctggcatccc gagaagccag gaagcagtga gcccaggagt cctcggccag ccctgcctgc       60

ccaccaggag gatgaaggtc tccgtggctg ccctctcctg cctcatgctt gttactgccc      120

ttggatccca ggcccgggtc acaaaagatg cagagacaga gttcatgatg tcaaagcttc      180

cattggaaaa tccagtactt ctggacatgc tctggaggag aaagattggt cctcagatga      240

ccctttctca tgctgcagga ttccatgcta ctagtgctga ctgctgcatc tcctacaccc      300

cacgaagcat cccgtgttca ctcctggaga gttactttga aacgaacagc gagtgctcca      360

agccgggtgt catcttcctc accaagaagg ggcgacgttt ctgtgccaac cccagtgata      420

agcaagttca ggtttgcgtg agaatgctga agctggacac acggatcaag accaggaaga      480

attgaacttg tcaaggtgaa gggacacaag ttgccagcca ccaactttct tgcctcaact      540

accttcctga attatttttt aaagaagcat ttattcttgt gttctggatt tagagcaatt      600

catctaataa acagtttctc actttaaaaa aaaaaaaaaa a                          641


<210>  4
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  4
ctggcatccc gagaagccag gaagcagtga gcccaggagt cctcggccag ccctgcctgc       60

ccaccaggag gatgaaggtc tccgtggctg ccctctcctg cctcatgctt gttactgccc      120

ttggatccca ggcccgggtc acaaaagatg cagagacaga gttcatgatg tcaaagcttc      180

cattggaaaa tccagtactt ctggacagat tccatgctac tagtgctgac tgctgcatct      240

cctacacccc acgaagcatc ccgtgttcac tcctggagag ttactttgaa acgaacagcg      300

agtgctccaa gccgggtgtc atcttcctca ccaagaaggg gcgacgtttc tgtgccaacc      360

ccagtgataa gcaagttcag gtttgcgtga gaatgctgaa gctggacaca cggatcaaga      420

ccaggaagaa ttgaacttgt caaggtgaag ggacacaagt tgccagccac caactttctt      480

gcctcaacta ccttcctgaa ttatttttta aagaagcatt tattcttgtg ttctggattt      540

agagcaattc atctaataaa cagtttctca ctttaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaa                                                                    603


<210>  5
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Met Leu Trp 
        35                  40                  45              


Arg Arg Lys Ile Gly Pro Gln Met Thr Leu Ser His Ala Ala Gly Phe 
    50                  55                  60                  


His Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile 
65                  70                  75                  80  


Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser 
                85                  90                  95      


Lys Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala 
            100                 105                 110         


Asn Pro Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu 
        115                 120                 125             


Asp Thr Arg Ile Lys Thr Arg Lys Asn 
    130                 135         


<210>  6
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Arg Phe His 
        35                  40                  45              


Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile Pro 
    50                  55                  60                  


Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser Lys 
65                  70                  75                  80  


Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala Asn 
                85                  90                  95      


Pro Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu Asp 
            100                 105                 110         


Thr Arg Ile Lys Thr Arg Lys Asn 
        115                 120 


<210>  7
<211>  1219
<212>  DNA
<213>  Homo sapiens

<400>  7
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga       60

actctacctc cagacagaat gaagttcatc tcgacatctc tgcttctcat gctgctggtc      120

agcagcctct ctccagtcca aggtgttctg gaggtctatt acacaagctt gaggtgtaga      180

tgtgtccaag agagctcagt ctttatccct agacgcttca ttgatcgaat tcaaatcttg      240

ccccgtggga atggttgtcc aagaaaagaa atcatagtct ggaagaagaa caagtcaatt      300

gtgtgtgtgg accctcaagc tgaatggata caaagaatga tggaagtatt gagaaaaaga      360

agttcttcaa ctctaccagt tccagtgttt aagagaaaga ttccctgatg ctgatatttc      420

cactaagaac acctgcattc ttcccttatc cctgctctgg attttagttt tgtgcttagt      480

taaatctttt ccaggaaaaa gaacttcccc atacaaataa gcatgagact atgtaaaaat      540

aaccttgcag aagctgatgg ggcaaactca agcttcttca ctcacagcac cctatataca      600

cttggagttt gcattcttat tcatcaggga ggaaagtttc tttgaaaata gttattcagt      660

tataagtaat acaggattat tttgattata tacttgttgt ttaatgttta aaatttctta      720

gaaaacaatg gaatgagaat ttaagcctca aatttgaaca tgtggcttga attaagaaga      780

aaattatggc atatattaaa agcaggcttc tatgaaagac tcaaaaagct gcctgggagg      840

cagatggaac ttgagcctgt caagaggcaa aggaatccat gtagtagata tcctctgctt      900

aaaaactcac tacggaggag aattaagtcc tacttttaaa gaatttcttt ataaaattta      960

ctgtctaaga ttaatagcat tcgaagatcc ccagacttca tagaatactc agggaaagca     1020

tttaaagggt gatgtacaca tgtatccttt cacacatttg ccttgacaaa cttctttcac     1080

tcacatcttt ttcactgact ttttttgtgg ggggcggggc cggggggact ctggtatcta     1140

attctttaat gattcctata aatctaatga cattcaataa agttgagcaa acattttact     1200

taaaaaaaaa aaaaaaaaa                                                  1219


<210>  8
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  9
<211>  3354
<212>  DNA
<213>  Homo sapiens

<400>  9
actagcgagc gccctgcgta ggcaccggct cctgagcccg tgcttcgggt gagggggcgg       60

gtcttccggc cctctcgaaa atcatttccg gcatgagccg gaagaccgtc ccggatggcc      120

tcggggactg ccagtgtgtg gaggtgagct ccgggattgc cggcattccc gcttctgctg      180

gttgcttcat gctgcaggct gcggccgtca gccctcgctc gcattggtgg cgctgaggtg      240

ccggggcagc aagtgacatg tcgtcgggcc tccgcgccgc tgacttcccc cgctggaagc      300

gccacatctc ggagcaactg aggcgccggg accggctgca gagacaggcg ttcgaggaga      360

tcatcctgca gtataacaaa ttgctggaaa agtcagatct tcattcagtg ttggcccaga      420

aactacaggc tgaaaagcat gacgtaccaa acaggcacga gataagtccc ggacatgatg      480

gcacatggaa tgacaatcag ctacaagaaa tggcccaact gaggattaag caccaagagg      540

aactgactga attacacaag aaacgtgggg agttagctca actggtgatt gacctgaata      600

accaaatgca gcggaaggac agggagatgc agatgaatga agcaaaaatt gcagaatgtt      660

tgcagactat ctctgacctg gagacggagt gcctagacct gcgcactaag ctttgtgacc      720

ttgaaagagc caaccagacc ctgaaggatg aatatgatgc cctgcagatc acttttactg      780

ccttggaggg aaaactgagg aaaactacgg aagagaacca ggagctggtc accagatgga      840

tggctgagaa agcccaggaa gccaatcggc ttaatgcaga gaatgaaaaa gactccagga      900

ggcggcaagc ccggctgcag aaagagcttg cagaagcagc aaaggaacct ctaccagtcg      960

aacaggatga tgacattgag gtcattgtgg atgaaacttc tgatcacaca gaagagacct     1020

ctcctgtgcg agccatcagc agagcagcca cgagacgctc tgtctcttcc ttcccagtcc     1080

cccaggacaa tgtggatact catcctggtt ctggtaaaga agtgagggta ccagctactg     1140

ccttgtgtgt cttcgatgca catgatgggg aagtcaacgc tgtgcagttc agtccaggtt     1200

cccggttact ggccactgga ggcatggacc gcagggttaa gctttgggaa gtatttggag     1260

aaaaatgtga gttcaagggt tccctatctg gcagtaatgc aggaattaca agcattgaat     1320

ttgatagtgc tggatcttac ctcttagcag cttcaaatga ttttgcaagc cgaatctgga     1380

ctgtggatga ttatcgatta cggcacacac tcacgggaca cagtgggaaa gtgctgtctg     1440

ctaagttcct gctggacaat gcgcggattg tctcaggaag tcacgaccgg actctcaaac     1500

tctgggatct acgcagcaaa gtctgcataa agacagtgtt tgcaggatcc agttgcaatg     1560

atattgtctg cacagagcaa tgtgtaatga gtggacattt tgacaagaaa attcgtttct     1620

gggacattcg atcagagagc atagttcgag agatggagct gttgggaaag attactgccc     1680

tggacttaaa cccagaaagg actgagctcc tgagctgctc ccgtgatgac ttgctaaaag     1740

ttattgatct ccgaacaaat gctatcaagc agacattcag tgcacctggg ttcaagtgcg     1800

gctctgactg gaccagagtt gtcttcagcc ctgatggcag ttacgtggcg gcaggctctg     1860

ctgagggctc tctgtatatc tggagtgtgc tcacagggaa agtggaaaag gttctttcaa     1920

agcagcacag ctcatccatc aatgcggtgg cgtggtcgcc ctctggctcg cacgttgtca     1980

gtgtggacaa aggatgcaaa gctgtgctgt gggcacagta ctgacggggc tctcagggct     2040

gggaggaccc cagtgccctc ctcagaagaa gcacatgggc tcctgcagcc ctgtcctggc     2100

aggtgatgtg ctgggtatag catggacctc ccagagaagc tcaagctatg tggcactgta     2160

gctttgccgt gaatgggatt tctgaagatt tgactgaggt ctctcttggc ctggaagaat     2220

aacactgaaa aaacctgacg ctgcggtcac ttagcagagg ctcaggttct tgccttggga     2280

aacactacta gctctgacct tccatacctc acttggggga gcacagggcc ccgctgggcc     2340

tcctcaccaa cggcagtgcc aaaatcagcc cccacatcaa ggtggtgttc tctgtgcttt     2400

ctctcgtcct tccaaagtcg gttctggcct aacgcatgtc ccaacacctt gggttcattt     2460

gcccggtgaa ctcactttaa gcattggatt aacggaaact cccgaactac agacccctcc     2520

ctggtgggtt gcatgaatgt gtctcattac tgctgaaatg tcctcacatc tctttcactg     2580

ttcttcagag ctttctggct ctctttcccc cacaaaattc gacatattta aaaatctccg     2640

tgtggcttta aaaaatggtt ttttgttttt ttgttttttt gaggtgggag aggatgtgtg     2700

aaaatctttt ccagggaaat gggttcgctg cagaggtaag gatgtgttcc tgtatcgatc     2760

tgcagacacc cagaaggtgg gtgcacactg catgcttggg ggtgccaagg gattcgagac     2820

ctccaacata cttgtctgaa ggtggtgatt ctggccatgg cccctctgcc aagcctgtgt     2880

gcgatgccct tggtgcttta gtgcaagaag cctaggctca gaagcacagc agcgccatct     2940

ttccgtttca ggggttgtga tgaaggccaa ggaaaaacat ttatctttac tattttacct     3000

acgtataaag ttttagttca ttgggtgtgc gaaacaccct ttttatcact tttaaatttg     3060

cactttattt tttttcttcc atgcttgttc tctggacatt tggggatgtg agtgttagag     3120

ctggtgagag aggagtcagg tggccttccc accgatggtc ctggcctcca cctgccctct     3180

cttccctgcc tgatcaccgc tttccaattt gcccttcaga gaacttaagt caaggagagt     3240

tgaaattcac aggccagggc acatctttta tttatttcat tatgttggcc aacagaactt     3300

gattgtaaat aataataaag aaatctgtta tatacttttc aaactccaaa aaaa           3354


<210>  10
<211>  3411
<212>  DNA
<213>  Homo sapiens

<400>  10
actagcgagc gccctgcgta ggcaccggct cctgagcccg tgcttcgggt gagggggcgg       60

gtcttccggc cctctcgaaa atcatttccg gcatgagccg gaagaccgtc ccggatggcc      120

tcggggactg ccagtgtgtg gaggtgagct ccgggattgc cggcattccc gcttctgctg      180

gttgcttcat gctgcaggct gcggccgtca gccctcgctc gcattggtgg cgctgaggtg      240

ccggggcagc aagtgacatg tcgtcgggcc tccgcgccgc tgacttcccc cgctggaagc      300

gccacatctc ggagcaactg aggcgccggg accggctgca gagacaggcg ttcgaggaga      360

tcatcctgca gtataacaaa ttgctggaaa agtcagatct tcattcagtg ttggcccaga      420

aactacaggc tgaaaagcat gacgtaccaa acaggcacga gataagtccc ggacatgatg      480

gcacatggaa tgacaatcag ctacaagaaa tggcccaact gaggattaag caccaagagg      540

aactgactga attacacaag aaacgtgggg agttagctca actggtgatt gacctgaata      600

accaaatgca gcggaaggac agggagatgc agatgaatga agcaaaaatt gcagaatgtt      660

tgcagactat ctctgacctg gagacggagt gcctagacct gcgcactaag ctttgtgacc      720

ttgaaagagc caaccagacc ctgaaggatg aatatgatgc cctgcagatc acttttactg      780

ccttggaggg aaaactgagg aaaactacgg aagagaacca ggagctggtc accagatgga      840

tggctgagaa agcccaggaa gccaatcggc ttaatgcaga gaatgaaaaa gactccagga      900

ggcggcaagc ccggctgcag aaagagcttg cagaagcagc aaaggaacct ctaccagtcg      960

aacaggatga tgacattgag gtcattgtgg atgaaacttc tgatcacaca gaagagacct     1020

ctcctgtgcg agccatcagc agagcagcca ctaagcgact ctcgcagcct gctggaggcc     1080

ttctggattc tatcactaat atctttggga gacgctctgt ctcttccttc ccagtccccc     1140

aggacaatgt ggatactcat cctggttctg gtaaagaagt gagggtacca gctactgcct     1200

tgtgtgtctt cgatgcacat gatggggaag tcaacgctgt gcagttcagt ccaggttccc     1260

ggttactggc cactggaggc atggaccgca gggttaagct ttgggaagta tttggagaaa     1320

aatgtgagtt caagggttcc ctatctggca gtaatgcagg aattacaagc attgaatttg     1380

atagtgctgg atcttacctc ttagcagctt caaatgattt tgcaagccga atctggactg     1440

tggatgatta tcgattacgg cacacactca cgggacacag tgggaaagtg ctgtctgcta     1500

agttcctgct ggacaatgcg cggattgtct caggaagtca cgaccggact ctcaaactct     1560

gggatctacg cagcaaagtc tgcataaaga cagtgtttgc aggatccagt tgcaatgata     1620

ttgtctgcac agagcaatgt gtaatgagtg gacattttga caagaaaatt cgtttctggg     1680

acattcgatc agagagcata gttcgagaga tggagctgtt gggaaagatt actgccctgg     1740

acttaaaccc agaaaggact gagctcctga gctgctcccg tgatgacttg ctaaaagtta     1800

ttgatctccg aacaaatgct atcaagcaga cattcagtgc acctgggttc aagtgcggct     1860

ctgactggac cagagttgtc ttcagccctg atggcagtta cgtggcggca ggctctgctg     1920

agggctctct gtatatctgg agtgtgctca cagggaaagt ggaaaaggtt ctttcaaagc     1980

agcacagctc atccatcaat gcggtggcgt ggtcgccctc tggctcgcac gttgtcagtg     2040

tggacaaagg atgcaaagct gtgctgtggg cacagtactg acggggctct cagggctggg     2100

aggaccccag tgccctcctc agaagaagca catgggctcc tgcagccctg tcctggcagg     2160

tgatgtgctg ggtatagcat ggacctccca gagaagctca agctatgtgg cactgtagct     2220

ttgccgtgaa tgggatttct gaagatttga ctgaggtctc tcttggcctg gaagaataac     2280

actgaaaaaa cctgacgctg cggtcactta gcagaggctc aggttcttgc cttgggaaac     2340

actactagct ctgaccttcc atacctcact tgggggagca cagggccccg ctgggcctcc     2400

tcaccaacgg cagtgccaaa atcagccccc acatcaaggt ggtgttctct gtgctttctc     2460

tcgtccttcc aaagtcggtt ctggcctaac gcatgtccca acaccttggg ttcatttgcc     2520

cggtgaactc actttaagca ttggattaac ggaaactccc gaactacaga cccctccctg     2580

gtgggttgca tgaatgtgtc tcattactgc tgaaatgtcc tcacatctct ttcactgttc     2640

ttcagagctt tctggctctc tttcccccac aaaattcgac atatttaaaa atctccgtgt     2700

ggctttaaaa aatggttttt tgtttttttg tttttttgag gtgggagagg atgtgtgaaa     2760

atcttttcca gggaaatggg ttcgctgcag aggtaaggat gtgttcctgt atcgatctgc     2820

agacacccag aaggtgggtg cacactgcat gcttgggggt gccaagggat tcgagacctc     2880

caacatactt gtctgaaggt ggtgattctg gccatggccc ctctgccaag cctgtgtgcg     2940

atgcccttgg tgctttagtg caagaagcct aggctcagaa gcacagcagc gccatctttc     3000

cgtttcaggg gttgtgatga aggccaagga aaaacattta tctttactat tttacctacg     3060

tataaagttt tagttcattg ggtgtgcgaa acaccctttt tatcactttt aaatttgcac     3120

tttatttttt ttcttccatg cttgttctct ggacatttgg ggatgtgagt gttagagctg     3180

gtgagagagg agtcaggtgg ccttcccacc gatggtcctg gcctccacct gccctctctt     3240

ccctgcctga tcaccgcttt ccaatttgcc cttcagagaa cttaagtcaa ggagagttga     3300

aattcacagg ccagggcaca tcttttattt atttcattat gttggccaac agaacttgat     3360

tgtaaataat aataaagaaa tctgttatat acttttcaaa ctccaaaaaa a              3411


<210>  11
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Arg Arg Ser Val Ser Ser Phe 
            260                 265                 270         


Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu 
        275                 280                 285             


Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly 
    290                 295                 300                 


Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr 
305                 310                 315                 320 


Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys 
                325                 330                 335     


Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser 
            340                 345                 350         


Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        355                 360                 365             


Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    370                 375                 380                 


Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
385                 390                 395                 400 


Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                405                 410                 415     


Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            420                 425                 430         


Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        435                 440                 445             


Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    450                 455                 460                 


Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
465                 470                 475                 480 


Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                485                 490                 495     


Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            500                 505                 510         


Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        515                 520                 525             


Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    530                 535                 540                 


Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
545                 550                 555                 560 


Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                565                 570                 575     


Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            580                 585             


<210>  12
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                 265                 270         


Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                 280                 285             


Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                 295                 300                 


Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                 310                 315                 320 


His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                 330                 335     


Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                 345                 350         


Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                 360                 365             


Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                 375                 380                 


Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                 390                 395                 400 


Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                 410                 415     


Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                 425                 430         


Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala 
        435                 440                 445             


Gly Ser Ser Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser 
    450                 455                 460                 


Gly His Phe Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser 
465                 470                 475                 480 


Ile Val Arg Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu 
                485                 490                 495     


Asn Pro Glu Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu 
            500                 505                 510         


Lys Val Ile Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala 
        515                 520                 525             


Pro Gly Phe Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro 
    530                 535                 540                 


Asp Gly Ser Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile 
545                 550                 555                 560 


Trp Ser Val Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His 
                565                 570                 575     


Ser Ser Ser Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val 
            580                 585                 590         


Val Ser Val Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
        595                 600                 605         


<210>  13
<211>  1929
<212>  DNA
<213>  Homo sapiens

<400>  13
ctggggacgg gggccgagta gcgccttccc cgggccccgt gaaccggctg cgggtcgccc       60

ttggggggca gcggccgcag ccccccacct gggccctcgg tccgccctcc cggcgcgtcc      120

atgaactcag tgtcgccggc cgccgcgcag taccggagca gcagcccgga ggacgcgcgc      180

cgccggcccg aggcccgcag gccgcggggt cccagaggcc cagaccccaa cggcctgggg      240

ccttccggag ccagcggccc cgctcttggc tctcccgggg ctggcccgag tgagccggac      300

gaagtggaca agttcaaggc caagttcctg acagcctgga acaacgtcaa gtacggttgg      360

gtggttaaaa gccggaccag ctttagcaag atctccagca tccacctctg tggccgccgc      420

taccgtttcg agggcgaggg tgacatacag cgtttccagc gggactttgt gtcccgcctg      480

tggctcacat accgccggga cttcccgccc cttcctgggg gctgcctgac ctcggactgt      540

ggctgggggt gcatgttacg cagcggccag atgatgctgg cacagggcct tctgctgcat      600

ttcctgccca gagactggac atgggccgag ggcatgggcc tgggcccccc tgagctgtca      660

gggtcagcct ctcccagccg gtaccatggg cctgcccgct ggatgccccc acgctgggcc      720

cagggtgccc ctgagctgga gcaggaacgc cggcaccggc agattgtgtc ctggttcgcc      780

gaccaccccc gggccccctt tggcctacac cggctggtgg agcttgggca gagctcaggc      840

aagaaggcag gtgactggta tgggccatcg ctagtggcac acatcctcag gaaagccgtg      900

gagagctgct ccgacgtcac ccgcctggtg gtgtacgttt ctcaggactg cacagtgtac      960

aaggcggatg tggcacgcct ggtggccagg ccagacccca cagccgagtg gaagtctgtg     1020

gtcatcctgg tgcccgtgcg actgggtggc gagactctca accccgtgta tgtgccctgc     1080

gtgaaggaac tcctgcgttg cgagctgtgc ctgggcatca tgggtgggaa accgcgacac     1140

tcactgtact tcattggcta ccaagatgac ttcctgctgt acctggaccc tcactactgc     1200

cagcccactg tggatgtcag ccaggccgac ttccccctgg agtccttcca ctgcacctcg     1260

ccccgcaaga tggcctttgc caagatggac ccaagctgta ccgtgggctt ctatgctgga     1320

gacaggaagg agtttgagac actctgctca gagctgacca gggtcctcag ctcctcctca     1380

gccacagagc ggtaccccat gttcaccctg gccgagggcc atgctcagga ccacagcctg     1440

gacgacctct gctcccagct cgcccagccc acactccggc tccctcgcac agggcggctc     1500

ctcagggcca aacgccccag ctctgaggac tttgtgtttt tataaaggga ggggatgagg     1560

ggaaagatac aacactattt atttttttat ttatgtcatg tcgggtgtgg gatcttgagc     1620

tctggcagtg atgatggtac ttcctgttgt cagcccctca agcccagctg caaccagtct     1680

ggggccattc agccagggac agagcccaca gagcccatac acctgtctcc caccagcggg     1740

gccctcctgg cagggtaggg aaggaggacc ccgggcaccc ccctcagggc ctgactcacg     1800

tactgtagtt tgcactggac gcccgggccc tccctgtccc aaagccccct tgggggaact     1860

gtggctgctg ggggccaata aagctgtgta acttgaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaa                                                             1929


<210>  14
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Ser Val Ser Pro Ala Ala Ala Gln Tyr Arg Ser Ser Ser Pro 
1               5                   10                  15      


Glu Asp Ala Arg Arg Arg Pro Glu Ala Arg Arg Pro Arg Gly Pro Arg 
            20                  25                  30          


Gly Pro Asp Pro Asn Gly Leu Gly Pro Ser Gly Ala Ser Gly Pro Ala 
        35                  40                  45              


Leu Gly Ser Pro Gly Ala Gly Pro Ser Glu Pro Asp Glu Val Asp Lys 
    50                  55                  60                  


Phe Lys Ala Lys Phe Leu Thr Ala Trp Asn Asn Val Lys Tyr Gly Trp 
65                  70                  75                  80  


Val Val Lys Ser Arg Thr Ser Phe Ser Lys Ile Ser Ser Ile His Leu 
                85                  90                  95      


Cys Gly Arg Arg Tyr Arg Phe Glu Gly Glu Gly Asp Ile Gln Arg Phe 
            100                 105                 110         


Gln Arg Asp Phe Val Ser Arg Leu Trp Leu Thr Tyr Arg Arg Asp Phe 
        115                 120                 125             


Pro Pro Leu Pro Gly Gly Cys Leu Thr Ser Asp Cys Gly Trp Gly Cys 
    130                 135                 140                 


Met Leu Arg Ser Gly Gln Met Met Leu Ala Gln Gly Leu Leu Leu His 
145                 150                 155                 160 


Phe Leu Pro Arg Asp Trp Thr Trp Ala Glu Gly Met Gly Leu Gly Pro 
                165                 170                 175     


Pro Glu Leu Ser Gly Ser Ala Ser Pro Ser Arg Tyr His Gly Pro Ala 
            180                 185                 190         


Arg Trp Met Pro Pro Arg Trp Ala Gln Gly Ala Pro Glu Leu Glu Gln 
        195                 200                 205             


Glu Arg Arg His Arg Gln Ile Val Ser Trp Phe Ala Asp His Pro Arg 
    210                 215                 220                 


Ala Pro Phe Gly Leu His Arg Leu Val Glu Leu Gly Gln Ser Ser Gly 
225                 230                 235                 240 


Lys Lys Ala Gly Asp Trp Tyr Gly Pro Ser Leu Val Ala His Ile Leu 
                245                 250                 255     


Arg Lys Ala Val Glu Ser Cys Ser Asp Val Thr Arg Leu Val Val Tyr 
            260                 265                 270         


Val Ser Gln Asp Cys Thr Val Tyr Lys Ala Asp Val Ala Arg Leu Val 
        275                 280                 285             


Ala Arg Pro Asp Pro Thr Ala Glu Trp Lys Ser Val Val Ile Leu Val 
    290                 295                 300                 


Pro Val Arg Leu Gly Gly Glu Thr Leu Asn Pro Val Tyr Val Pro Cys 
305                 310                 315                 320 


Val Lys Glu Leu Leu Arg Cys Glu Leu Cys Leu Gly Ile Met Gly Gly 
                325                 330                 335     


Lys Pro Arg His Ser Leu Tyr Phe Ile Gly Tyr Gln Asp Asp Phe Leu 
            340                 345                 350         


Leu Tyr Leu Asp Pro His Tyr Cys Gln Pro Thr Val Asp Val Ser Gln 
        355                 360                 365             


Ala Asp Phe Pro Leu Glu Ser Phe His Cys Thr Ser Pro Arg Lys Met 
    370                 375                 380                 


Ala Phe Ala Lys Met Asp Pro Ser Cys Thr Val Gly Phe Tyr Ala Gly 
385                 390                 395                 400 


Asp Arg Lys Glu Phe Glu Thr Leu Cys Ser Glu Leu Thr Arg Val Leu 
                405                 410                 415     


Ser Ser Ser Ser Ala Thr Glu Arg Tyr Pro Met Phe Thr Leu Ala Glu 
            420                 425                 430         


Gly His Ala Gln Asp His Ser Leu Asp Asp Leu Cys Ser Gln Leu Ala 
        435                 440                 445             


Gln Pro Thr Leu Arg Leu Pro Arg Thr Gly Arg Leu Leu Arg Ala Lys 
    450                 455                 460                 


Arg Pro Ser Ser Glu Asp Phe Val Phe Leu 
465                 470                 


<210>  15
<211>  1372
<212>  DNA
<213>  Homo sapiens

<400>  15
cgggtgctga tgcgagtcgg tggcagcgag gacattttct gactccctgg cccctgacac       60

ggctgcactt tccatcccgt cgcggggccg gccgctactc cggccccagg atgcagaatg      120

tgattaatac tgtgaaggga aaggcactgg aagtggctga gtacctgacc ccggtcctca      180

aggaatcaaa gtttaaggaa acaggtgtaa ttaccccaga agagtttgtg gcagctggag      240

atcacctagt ccaccactgt ccaacatggc aatgggctac aggggaagaa ttgaaagtga      300

aggcatacct accaacaggc aaacaatttt tggtaaccaa aaatgtgccg tgctataagc      360

ggtgcaaaca gatggaatat tcagatgaat tggaagctat cattgaagaa gatgatggtg      420

atggcggatg ggtagataca tatcacaaca caggtattac aggaataacg gaagccgtta      480

aagagatcac actggaaaat aaggacaata taaggcttca agattgctca gcactatgtg      540

aagaggaaga agatgaagat gaaggagaag ctgcagatat ggaagaatat gaagagagtg      600

gattgttgga aacagatgag gctaccctag atacaaggaa aatagtagaa gcttgtaaag      660

ccaaaactga tgctggcggt gaagatgcta ttttgcaaac cagaacttat gacctttaca      720

tcacttatga taaatattac cagactccac gattatggtt gtttggctat gatgagcaac      780

ggcagccttt aacagttgag cacatgtatg aagacatcag tcaggatcat gtgaagaaaa      840

cagtgaccat tgaaaatcac cctcatctgc caccacctcc catgtgttca gttcacccat      900

gcaggcatgc tgaggtgatg aagaaaatca ttgagactgt tgcagaagga gggggagaac      960

ttggagttca tatgtatctt cttattttct tgaaatttgt acaagctgtc attccaacaa     1020

tagaatatga ctacacaaga cacttcacaa tgtaatgaag agagcataaa atctatccta     1080

attattggtt ctgattttta aagaattaac ccatagatgt gaccattgac catattcatc     1140

aatatataca gtttctctaa taagggactt atatgtttat gcattaaata aaaatatgtt     1200

ccactaccag ccttacttgt ttaataaaaa tcagtgcaaa gaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1372


<210>  16
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Asn Val Ile Asn Thr Val Lys Gly Lys Ala Leu Glu Val Ala 
1               5                   10                  15      


Glu Tyr Leu Thr Pro Val Leu Lys Glu Ser Lys Phe Lys Glu Thr Gly 
            20                  25                  30          


Val Ile Thr Pro Glu Glu Phe Val Ala Ala Gly Asp His Leu Val His 
        35                  40                  45              


His Cys Pro Thr Trp Gln Trp Ala Thr Gly Glu Glu Leu Lys Val Lys 
    50                  55                  60                  


Ala Tyr Leu Pro Thr Gly Lys Gln Phe Leu Val Thr Lys Asn Val Pro 
65                  70                  75                  80  


Cys Tyr Lys Arg Cys Lys Gln Met Glu Tyr Ser Asp Glu Leu Glu Ala 
                85                  90                  95      


Ile Ile Glu Glu Asp Asp Gly Asp Gly Gly Trp Val Asp Thr Tyr His 
            100                 105                 110         


Asn Thr Gly Ile Thr Gly Ile Thr Glu Ala Val Lys Glu Ile Thr Leu 
        115                 120                 125             


Glu Asn Lys Asp Asn Ile Arg Leu Gln Asp Cys Ser Ala Leu Cys Glu 
    130                 135                 140                 


Glu Glu Glu Asp Glu Asp Glu Gly Glu Ala Ala Asp Met Glu Glu Tyr 
145                 150                 155                 160 


Glu Glu Ser Gly Leu Leu Glu Thr Asp Glu Ala Thr Leu Asp Thr Arg 
                165                 170                 175     


Lys Ile Val Glu Ala Cys Lys Ala Lys Thr Asp Ala Gly Gly Glu Asp 
            180                 185                 190         


Ala Ile Leu Gln Thr Arg Thr Tyr Asp Leu Tyr Ile Thr Tyr Asp Lys 
        195                 200                 205             


Tyr Tyr Gln Thr Pro Arg Leu Trp Leu Phe Gly Tyr Asp Glu Gln Arg 
    210                 215                 220                 


Gln Pro Leu Thr Val Glu His Met Tyr Glu Asp Ile Ser Gln Asp His 
225                 230                 235                 240 


Val Lys Lys Thr Val Thr Ile Glu Asn His Pro His Leu Pro Pro Pro 
                245                 250                 255     


Pro Met Cys Ser Val His Pro Cys Arg His Ala Glu Val Met Lys Lys 
            260                 265                 270         


Ile Ile Glu Thr Val Ala Glu Gly Gly Gly Glu Leu Gly Val His Met 
        275                 280                 285             


Tyr Leu Leu Ile Phe Leu Lys Phe Val Gln Ala Val Ile Pro Thr Ile 
    290                 295                 300                 


Glu Tyr Asp Tyr Thr Arg His Phe Thr Met 
305                 310                 


<210>  17
<211>  2359
<212>  DNA
<213>  Homo sapiens

<400>  17
cgaccgagca cagacacgtt gcccaccgct cctctcccga ggtctgtagt cgcggagaaa       60

cacatgttgc gttactaacg ttcagaggtc tgcgacagct tcgatttgaa tgactagccg      120

ggaacaccaa gtttcactgt gtaattgcgt ccccctactc cggcgcctcc tttgcgacgc      180

tccctggaga aaagcacgcc cactgcacgc gctcagtcgc tacttccgct ctcgagtgtc      240

tccaagcaag atggcggagg agccgcagtc tgtgttgcag cttcctactt caattgctgc      300

tggaggggaa ggacttacgg atgtctcccc agaaacaacc accccggagc ccccgtcttc      360

cgctgcagtt tccccgggaa cagaggaacc tgctggcgac accaagaaaa aaattgacat      420

tttgctaaag gctgtgggag acactcctat tatgaaaaca aagaagtggg cagtagagcg      480

aacacgaacc atccaaggac tcattgactt catcaaaaag tttcttaaac ttgtggcctc      540

agaacagttg tttatttatg tgaatcagtc ctttgctcct tccccagacc aagaagttgg      600

aactctctat gagtgttttg gcagtgatgg taaactggtt ttacattact gcaagtctca      660

ggcgtgggga tgaaccacaa agaaaatcaa cttgctacta catgaaatgg attttcacgg      720

aagagacagc tctgaaaagt tttgatgctt gtggcaagag acttaacaga tgtgatctat      780

ttagtatgtg tctactctat gtttatgcat aagaaaacat ccatagcatg aatggactca      840

gaaaaatgtg atttgtatta atgcaccagt catcataaaa gatggtcatg atagtacacc      900

cattgctcct acttgttact attattgctg cagatctgcc tccaaggttg aaaaggagac      960

taagactgta taaacatctt cattgtcagt tctcaaaatg actgaaattg ttttcatggt     1020

aaaagttaat atactaaagg gttccttttt ttttaatgtt tacatttatc tctatgttta     1080

cctttttagt cacattgacc tgctggctga atacctcaaa tagtccagta gagggcagtc     1140

caccaggcag aaaaggttag gcgttttggt ttcacatctt tgctggggaa taatagggga     1200

aatggctgtt tttgctaatt tttagctaat atctagccag gagagcaagc acataggaca     1260

gactgaaaga ctgtaatttt acacaataca catggcttaa ttattttatt gggatacaga     1320

aaaatataaa ttctggacaa ataagtcata tacctgtttt cagtcctaac atttaaggat     1380

tcttgagtcc caatcacata actgtggtgt tactctgtca tttatatggt gtcaaaagca     1440

cttgatgagt aaacccagta gcatcttttt gagtgtttca taatgcattt tccaacttga     1500

aaacaataat tgaaaaatag ccttattgta tattttatgc catgactaaa agtgccattt     1560

ttactgatgc tattagactg ataatttctt gaagtgaaat ttaacctttt tttctcttta     1620

gtattatgtt tataatgcca tatttttaga aagcattcca gatcaggcat ggtggcttac     1680

acctgtaatc ccagcacttt ggaaggctga ggtgtgggga ttgcgtgaag ccacaagttt     1740

gagaccagcc tggttagcaa ggcaagatcc ccaactctac aaaaaaataa aaattaaaaa     1800

aaaattatta ggctgcagag gcaagaggat cccctgagcc cagaagttca agggtatagt     1860

gagtcgtgat tgtaccactg cattcctgct gagcaacaga gtgagacccc atctcaaaaa     1920

agaaaaaaaa aggcattcta gtaaatcgaa tgtaatgtga atggaatttc aaaacaggat     1980

ctaagatggt atgtagtaga attcaaagta atatcatttt aaagttaaat gagtatggaa     2040

aaggtctgtt ctctagtttt gtccagttca gtttactgaa ggaatatatt taattatatt     2100

catatattta acaaataaaa atatgttgaa ttttcgtatt gtttgccact gagggttcag     2160

atgatagacc tcaaaaaatc gaaaatactg gttgaaattt gtagcatcca tttagttatt     2220

ctttttgacc taaataactt aatagtttat taaatctaag gttagctaaa tatgtagcta     2280

accttatttg ttttctttcc taacaactct gaagaataca taggactttg cacttttttt     2340

tttttttttt ttttttaaa                                                  2359


<210>  18
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ser Arg Glu His Gln Val Ser Leu Cys Asn Cys Val Pro Leu 
1               5                   10                  15      


Leu Arg Arg Leu Leu Cys Asp Ala Pro Trp Arg Lys Ala Arg Pro Leu 
            20                  25                  30          


His Ala Leu Ser Arg Tyr Phe Arg Ser Arg Val Ser Pro Ser Lys Met 
        35                  40                  45              


Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Thr Ser Ile Ala Ala 
    50                  55                  60                  


Gly Gly Glu Gly Leu Thr Asp Val Ser Pro Glu Thr Thr Thr Pro Glu 
65                  70                  75                  80  


Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Thr Glu Glu Pro Ala Gly 
                85                  90                  95      


Asp Thr Lys Lys Lys Ile Asp Ile Leu Leu Lys Ala Val Gly Asp Thr 
            100                 105                 110         


Pro Ile Met Lys Thr Lys Lys Trp Ala Val Glu Arg Thr Arg Thr Ile 
        115                 120                 125             


Gln Gly Leu Ile Asp Phe Ile Lys Lys Phe Leu Lys Leu Val Ala Ser 
    130                 135                 140                 


Glu Gln Leu Phe Ile Tyr Val Asn Gln Ser Phe Ala Pro Ser Pro Asp 
145                 150                 155                 160 


Gln Glu Val Gly Thr Leu Tyr Glu Cys Phe Gly Ser Asp Gly Lys Leu 
                165                 170                 175     


Val Leu His Tyr Cys Lys Ser Gln Ala Trp Gly 
            180                 185         


<210>  19
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  19
tgggcgggag gaacgcgccg ctaggcggga gagcgcggcc atggcggggc cgggcgtccc       60

cggtgccccc gcagcgcgct ggaaacgcca catcgtgcgg cagctgcggc ttcgggaccg      120

tacgcaaaag gcgcttttcc tggagctggt gccggcctat aaccatctct tagagaaggc      180

tgagctgctg gacaagttct caaagaagct gcagccggag ccaaacagtg tcactcccac      240

cacccaccag ggcccctggg aggagtcaga gcttgactca gaccaagtcc catcactggt      300

cgcactgagg gtgaagtggc aggaggagga ggaggggctc cggctggtct gtggtgagat      360

ggcctaccag gtggtggaga agggcgcggc cctgggcacg ctggagtcgg agctgcagca      420

gaggcaaagc aggctggcag ccctggaggc ccgcgtggcg cagctgcgag aggcgcgggc      480

gcagcaggcc cagcaggtgg aggagtggcg ggcgcagaat gcggtgcagc gggcagccta      540

cgaggcgctg cgcgcgcacg tcgggctccg ggaggcggca ctgcgcaggc tccaggaaga      600

ggcgcgcgac ctgctggaga ggctcgtgca gcgcaaggcg cgcgccgcgg ccgagcgcaa      660

cctgcgcaac gagcgccggg agcgggccaa gcaggcgcgg gtgtcccagg agctgaagaa      720

ggctgccaag cggaccgtga gcatcagcga gggcccggac accctaggcg atgggatgag      780

ggagagaagg gagactctgg ctctggcccc tgagccagag cccctggaga aggaagcttg      840

tgagaagtgg aagaggccct tcaggtctgc ctcagccacc tccctgacgc tgtcccactg      900

tgtggatgtg gtgaaggggc ttctggattt taagaagagg agaggtcact caattggggg      960

agcccctgag cagcgatacc agatcatccc tgtgtgtgtg gctgcccgac ttcctacccg     1020

ggctcaggat gtgctggatg cccacctctc tgaggtcaat gctgttcgtt ttggccccaa     1080

cagcagcctc ctggccactg gaggggctga ccgcctgatc cacctctgga atgttgtggg     1140

aagtcgcctg gaggccaacc agaccctgga gggagctggt ggcagcatca ccagtgtgga     1200

ctttgacccc tcgggctacc aggttttagc agcaacttac aaccaggctg cccagctctg     1260

gaaggtgggg gaggcacagt ccaaggagac actgtctgga cacaaggata aggtgacagc     1320

tgccaaattc aagctaacga ggcaccaggc agtgactggg agccgcgacc ggacagtgaa     1380

ggagtgggac ctcggccgtg cctattgctc caggaccatc aatgtccttt cctactgtaa     1440

tgacgtggtg tgtggggacc atatcatcat tagtggccac aatgaccaga agatccggtt     1500

ctgggacagc agggggcccc actgcaccca ggtcatccct gtgcagggcc gggtcacctc     1560

cctgagcctc agccacgacc aactgcacct gctcagctgt tcccgagaca acacactcaa     1620

ggtcatcgac ctgcgtgtca gcaacatccg ccaggtgttc agggccgatg gcttcaagtg     1680

tggttctgac tggaccaaag ctgtgttcag cccggacaga agctatgcac tggcaggctc     1740

ctgtgatggg gccctttaca tctgggatgt ggacaccggg aaactggaga gcagactaca     1800

gggaccccat tgcgctgccg tcaacgccgt ggcctggtgc tactccggga gccacatggt     1860

gagcgtggac cagggcagga aggttgtgct ctggcagtag ggccacgacc tgcctgcctg     1920

ggctggagct cttgcccgaa gcctgaagct tccttcggcg ccatgcaggg gttggggttg     1980

ggactggagc tggccttggg atttaatggg gaagaaggcc tggcaggacc tggcctgttt     2040

gtttaaaaat gaagtatggg ttgggggatt acgctagttt ttctttgtat ttttatctct     2100

atctcctcac tttttctccc aaagtagaaa aaaatgatat ctgaaaaaaa aaaaaaaaaa     2160


<210>  20
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Gly Pro Gly Val Pro Gly Ala Pro Ala Ala Arg Trp Lys Arg 
1               5                   10                  15      


His Ile Val Arg Gln Leu Arg Leu Arg Asp Arg Thr Gln Lys Ala Leu 
            20                  25                  30          


Phe Leu Glu Leu Val Pro Ala Tyr Asn His Leu Leu Glu Lys Ala Glu 
        35                  40                  45              


Leu Leu Asp Lys Phe Ser Lys Lys Leu Gln Pro Glu Pro Asn Ser Val 
    50                  55                  60                  


Thr Pro Thr Thr His Gln Gly Pro Trp Glu Glu Ser Glu Leu Asp Ser 
65                  70                  75                  80  


Asp Gln Val Pro Ser Leu Val Ala Leu Arg Val Lys Trp Gln Glu Glu 
                85                  90                  95      


Glu Glu Gly Leu Arg Leu Val Cys Gly Glu Met Ala Tyr Gln Val Val 
            100                 105                 110         


Glu Lys Gly Ala Ala Leu Gly Thr Leu Glu Ser Glu Leu Gln Gln Arg 
        115                 120                 125             


Gln Ser Arg Leu Ala Ala Leu Glu Ala Arg Val Ala Gln Leu Arg Glu 
    130                 135                 140                 


Ala Arg Ala Gln Gln Ala Gln Gln Val Glu Glu Trp Arg Ala Gln Asn 
145                 150                 155                 160 


Ala Val Gln Arg Ala Ala Tyr Glu Ala Leu Arg Ala His Val Gly Leu 
                165                 170                 175     


Arg Glu Ala Ala Leu Arg Arg Leu Gln Glu Glu Ala Arg Asp Leu Leu 
            180                 185                 190         


Glu Arg Leu Val Gln Arg Lys Ala Arg Ala Ala Ala Glu Arg Asn Leu 
        195                 200                 205             


Arg Asn Glu Arg Arg Glu Arg Ala Lys Gln Ala Arg Val Ser Gln Glu 
    210                 215                 220                 


Leu Lys Lys Ala Ala Lys Arg Thr Val Ser Ile Ser Glu Gly Pro Asp 
225                 230                 235                 240 


Thr Leu Gly Asp Gly Met Arg Glu Arg Arg Glu Thr Leu Ala Leu Ala 
                245                 250                 255     


Pro Glu Pro Glu Pro Leu Glu Lys Glu Ala Cys Glu Lys Trp Lys Arg 
            260                 265                 270         


Pro Phe Arg Ser Ala Ser Ala Thr Ser Leu Thr Leu Ser His Cys Val 
        275                 280                 285             


Asp Val Val Lys Gly Leu Leu Asp Phe Lys Lys Arg Arg Gly His Ser 
    290                 295                 300                 


Ile Gly Gly Ala Pro Glu Gln Arg Tyr Gln Ile Ile Pro Val Cys Val 
305                 310                 315                 320 


Ala Ala Arg Leu Pro Thr Arg Ala Gln Asp Val Leu Asp Ala His Leu 
                325                 330                 335     


Ser Glu Val Asn Ala Val Arg Phe Gly Pro Asn Ser Ser Leu Leu Ala 
            340                 345                 350         


Thr Gly Gly Ala Asp Arg Leu Ile His Leu Trp Asn Val Val Gly Ser 
        355                 360                 365             


Arg Leu Glu Ala Asn Gln Thr Leu Glu Gly Ala Gly Gly Ser Ile Thr 
    370                 375                 380                 


Ser Val Asp Phe Asp Pro Ser Gly Tyr Gln Val Leu Ala Ala Thr Tyr 
385                 390                 395                 400 


Asn Gln Ala Ala Gln Leu Trp Lys Val Gly Glu Ala Gln Ser Lys Glu 
                405                 410                 415     


Thr Leu Ser Gly His Lys Asp Lys Val Thr Ala Ala Lys Phe Lys Leu 
            420                 425                 430         


Thr Arg His Gln Ala Val Thr Gly Ser Arg Asp Arg Thr Val Lys Glu 
        435                 440                 445             


Trp Asp Leu Gly Arg Ala Tyr Cys Ser Arg Thr Ile Asn Val Leu Ser 
    450                 455                 460                 


Tyr Cys Asn Asp Val Val Cys Gly Asp His Ile Ile Ile Ser Gly His 
465                 470                 475                 480 


Asn Asp Gln Lys Ile Arg Phe Trp Asp Ser Arg Gly Pro His Cys Thr 
                485                 490                 495     


Gln Val Ile Pro Val Gln Gly Arg Val Thr Ser Leu Ser Leu Ser His 
            500                 505                 510         


Asp Gln Leu His Leu Leu Ser Cys Ser Arg Asp Asn Thr Leu Lys Val 
        515                 520                 525             


Ile Asp Leu Arg Val Ser Asn Ile Arg Gln Val Phe Arg Ala Asp Gly 
    530                 535                 540                 


Phe Lys Cys Gly Ser Asp Trp Thr Lys Ala Val Phe Ser Pro Asp Arg 
545                 550                 555                 560 


Ser Tyr Ala Leu Ala Gly Ser Cys Asp Gly Ala Leu Tyr Ile Trp Asp 
                565                 570                 575     


Val Asp Thr Gly Lys Leu Glu Ser Arg Leu Gln Gly Pro His Cys Ala 
            580                 585                 590         


Ala Val Asn Ala Val Ala Trp Cys Tyr Ser Gly Ser His Met Val Ser 
        595                 600                 605             


Val Asp Gln Gly Arg Lys Val Val Leu Trp Gln 
    610                 615                 


<210>  21
<211>  2304
<212>  DNA
<213>  Homo sapiens

<400>  21
acgctgcgtg ccgctgctgg gttccgccac gcccgtcatg gcggcggccc cggccggctc       60

tggccccgcc cctcggtgac gcgtcgcgag tcacctgacc aggctgcggg ctgaggagat      120

acaagggaag tggctatcgc cagagtcgga ttcgccgccg cagcagccgc cgcccccggg      180

agccgccggg accctcgcgt cgtcgccgcc gccgccgccc agatccctgc accatgccgt      240

cggagaagac cttcaagcag cgccgcacct tcgaacaaag agtagaagat gtccgactta      300

ttcgagagca gcatccaacc aaaatcccgg tgataataga acgatacaag ggtgagaagc      360

agcttcctgt tctggataaa acaaagttcc ttgtacctga ccatgtcaac atgagtgagc      420

tcatcaagat aattagaagg cgcttacagc tcaatgctaa tcaggccttc ttcctgttgg      480

tgaacggaca cagcatggtc agcgtctcca caccaatctc agaggtgtat gagagtgaga      540

aagatgaaga tggattcctg tacatggtct atgcctccca ggagacgttc gggatgaaat      600

tgtcagtgta aaaccagaaa aaatgcagct cttctagaat tgtttaaacc cttaccaagg      660

aaaaaaaagg gatgttacca actgagatcg atcagttcat ccaatcacag atcatgaaac      720

agtagtgttc ccacctagga gtgttaggaa gttgtgtttg tgtttcaagc agaaaaactg      780

agctccaagt gagcacattc agctttggaa actatattat ttaatgtagg ctagcttgtt      840

ttcaaatttt aaaagtttaa aaataaaata ctttgcattc taagttgcca ataaaataga      900

ccttcaagtt attttaatgc tcttttctca ctaataggaa cttgtaattc cagcagtaat      960

ttaaaggctt tcagagagac cctgagtctt ctcttcaggt tcacagaacc cgccgccttt     1020

ttgggtagaa gttttctact cagctagaga gatctcccta agaggatctt taggcctgag     1080

ttgtgaagcg caacccccgc aaaacgcatt tgccatcaca gttggcacaa acgcagggta     1140

aacgggctgt gtgagaaaac ggccctgact gtaaactgct gaaggtccct gactcctaag     1200

agaaccacac ccaaagtcct cactcttgca ggggtagaca tttctggttt ggtttgttct     1260

ctagatagtt acacacataa agacaccact caaaaggaaa cttgaataat ttataatttt     1320

gatcgagttt cttaaaagac cctggagaaa gagtggcatt tcttctgttt caggttttgt     1380

ctgagttcaa actagtgcct gtgttgttac ggaaagcagc agtgtaccag tgtcactctg     1440

gagtacagcg ggagaaacac aaaatagtat aactgaaaac attaacattc agacacactc     1500

ccttctgcct tccggcttaa agctgtggat gatccacgtt tttgtttttt taatgttaaa     1560

tgtgtaactc agtattactg aaaaggtacc cacattttga atagtagtta tcactcttag     1620

gtcagacagc catcagaatt ctcccacacc aagtgcatgt cagttgtgga gaaaacatag     1680

caaaaagagc cgtacgctct ttacagatac taatgtcaag agttaaacct cctcaggttc     1740

aacctgtgat aaaagactag tgcttcccag tacttgcatg gggttcacta tttatagttt     1800

tcttgggagt atcacaggaa aatcacaatt acaccacttt agaccctatg tgtagcaggt     1860

cacaacttac ccttgtgtgt ttagatgtgt atgaaatacc tgtatacgtt agtgaaagct     1920

gtttactgta acggggaaaa ccagattctt tgcatctggg ccctctactg attgttaaag     1980

gagttcctgt cacctgctcc ccccaccccc gcatgcgtct gtccacttgg ctaactttta     2040

atatgtgtat ttttacatta tgtatattct taactggact gtctcgttta gactgtatac     2100

atcatatctg acattattgt aactaccgtg tgatcagtaa gattcctgta agaaatactg     2160

ctttttaaga aaaaaaataa catgctgagg ggtgacctat atcccatgtg agtggtcact     2220

ttatttatag gatctttaaa acatttttaa tgaactaagt tgaataaagg cacaattaaa     2280

aactgtcaaa aaaaaaaaaa aaaa                                            2304


<210>  22
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


