                         SEQUENCE LISTING

<110>  UNIVERSITE HENRI POINCARE NANCY 1
       UNIVERSITY OF WARWICK
	 INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
       Aigle, Bertrand
       Challis, Greg L.
       Laureti, Luisa
       Song, Lijiang
       Pierre, Leblond
 
<120>  STAMBOMYCIN AND DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS 
       DRUGS

<130>  WOB 09 AX NAN AMBO

<150>  EP 09290587.6
<151>  2009-07-24

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  958
<212>  PRT
<213>  Streptomyces ambofaciens

<400>  1

Met Leu Val His Arg Asp Glu Gln Leu Ala His Leu Arg Trp Ala Phe 
1               5                   10                  15      


His Ala Cys Glu Lys His Gly His Gly Gln Val Ala Leu Val Thr Gly 
            20                  25                  30          


Ala Val Gly Ser Gly Lys Thr Gln Val Leu Glu Thr Phe Gly Glu Trp 
        35                  40                  45              


Ala Ala Thr Ala Gly Gly Gln Val Leu Ser Ala Ala Gly Ser Arg Ala 
    50                  55                  60                  


Glu Gln Gly Leu His Phe Gly Val Leu Gly Gln Leu Leu His Ser Ala 
65                  70                  75                  80  


Arg Leu Lys Pro Glu Gly Ile Arg Glu Val Glu Glu Leu Ile Arg Glu 
                85                  90                  95      


Val Ala Leu Ala Val Pro Thr Ala Glu Ala Arg Ser Gly Ala Ala Pro 
            100                 105                 110         


Glu Thr Leu Ala Glu Ala Leu Thr Ala Asp Gly Leu Trp Ala Pro Leu 
        115                 120                 125             


Leu Arg Thr Ala Phe Asp Thr Phe Leu Thr Leu Ala Gly Arg Gly Pro 
    130                 135                 140                 


Leu Val Leu Ala Val Asp Asp Leu Gln His Thr Asp Ala Ala Ser Leu 
145                 150                 155                 160 


His Cys Leu Leu Tyr Val Thr Arg Arg Leu Arg Asn Ala Arg Ile Met 
                165                 170                 175     


Val Leu Leu Ser Glu Ala Thr Thr Leu Arg Pro Ala His Pro Leu Phe 
            180                 185                 190         


His Ala Glu Leu Arg Ser Leu Pro Arg Phe Thr Arg Val Thr Leu Pro 
        195                 200                 205             


Leu Leu Thr Ala Asp Ser Val Ser Arg Leu Leu Gly Glu Glu Ala Gly 
    210                 215                 220                 


Thr Pro Asp Val Arg Gly Asp Gly Ala Gly Ala Pro Asp Val Arg Glu 
225                 230                 235                 240 


Glu Ala Gly Arg Ile Leu Arg Val Thr Gly Gly Asn Pro Leu Leu Ser 
                245                 250                 255     


Gln Ala Leu Val Asp Glu Arg Ala His Arg Gly Thr Asp Ser Ala Pro 
            260                 265                 270         


Asp Thr Gly Ala Arg Ala Gly Asp Thr Phe Glu Arg Ala Val Leu Asp 
        275                 280                 285             


Cys Leu Tyr Arg His Glu Pro Gly Val Arg Leu Val Ala Gln Ala Leu 
    290                 295                 300                 


Ala Ala Leu Asp Arg Pro Ala Ser Pro Glu Leu Leu Gly Gln Leu Leu 
305                 310                 315                 320 


Asp Val Leu Pro Asp Ser Thr Val Pro Ala Val Arg Val Leu Glu Gly 
                325                 330                 335     


Ala Gly Leu Val His Ala Gly Arg Leu Arg His Pro Arg Ile Val Leu 
            340                 345                 350         


Ala Val Arg Ser Asp Met Pro Ala Glu Glu Arg Arg Arg Leu His Gln 
        355                 360                 365             


Arg Ala Ala Glu Val Leu His Glu Asn Gly Ala Glu Ala Ser Val Val 
    370                 375                 380                 


Ala Glu His Leu Val Ala Ser Ala Trp Thr Asp Gly Ala Trp Val Val 
385                 390                 395                 400 


Pro Val Leu Arg Asp Ala Ala Ala His Ala Leu Ser Thr Gly Arg Pro 
                405                 410                 415     


Asp His Ala Ala Ala Cys Leu Arg Leu Gly Gly Arg Ala Glu Thr Asp 
            420                 425                 430         


Lys Asp Arg Arg Asn Ser Leu Met Ala Met Leu Ile Thr Ala Arg Trp 
        435                 440                 445             


Gln Val Asn Pro Leu Ala Val Thr Gly Gln Val Ser Gln Leu Val Glu 
    450                 455                 460                 


Ala Ala Arg Ala Asp Glu Ser Ser Pro Ser Thr Ala Val Ser Ala Val 
465                 470                 475                 480 


Pro Tyr Leu Leu Trp Gln Gly Arg Ala Glu Glu Ala Ala Glu Ala Ile 
                485                 490                 495     


Ser Gly Cys Gly Ala Gly Asp His Gly Pro Ala Ser Asn Glu Leu Arg 
            500                 505                 510         


Leu Thr Arg Leu Leu Ile Ala Leu Ser His Pro Asp Tyr Leu Gly Thr 
        515                 520                 525             


Val Arg Glu Asp Pro Ser Ser Trp Thr Arg Ala Ala Thr Ala Pro Asp 
    530                 535                 540                 


Ser Ala Ser Pro Leu Leu Gln Ala Val Ser Val Leu Gly Asn Ala Leu 
545                 550                 555                 560 


Met Pro Thr Gly Gly Val Asp Thr Val Ala Ala Ala Glu Gln Leu Leu 
                565                 570                 575     


Glu Arg His His Thr Asp Ser Gly Ser Leu Gly Leu Leu Thr Ala Pro 
            580                 585                 590         


Leu Leu Ala Leu Leu Cys Ala Gly Pro Ala Asp Arg Val Ala Val Trp 
        595                 600                 605             


Gly Glu Arg Leu Leu Ala Arg Gln Gly Val Gln His Thr Pro Ala Trp 
    610                 615                 620                 


Arg Gly Val Ile Arg Ala Ile His Ala Glu Ala Thr Leu Arg Leu Gly 
625                 630                 635                 640 


Asp Met Asp Ala Ala Glu Arg Gly Ala Arg Leu Ala Leu Glu Asp Leu 
                645                 650                 655     


Pro Ala Pro Ala Trp Gly Val Ala Val Gly Gly Pro Leu Gly Thr Leu 
            660                 665                 670         


Ile Thr Cys Thr Thr Glu Ser Gly Arg Leu Phe Glu Ala Glu Arg Trp 
        675                 680                 685             


Leu Ser Gln Pro Val Pro Ala Gly Val Phe Arg Thr Pro Val Gly Ala 
    690                 695                 700                 


His Tyr Leu Ile Ala Arg Gly Arg His His Leu Ala Met Gly Gln His 
705                 710                 715                 720 


Gln Ala Ala Ala Ala Asp Leu His Arg Ser Gly Glu Leu Val Arg Ser 
                725                 730                 735     


Trp Gly Ile Asp Val Ala Gly Leu Val Pro Trp Arg Leu Glu Leu Ala 
            740                 745                 750         


Arg Val Gln Leu Ser Leu Gly His Arg Thr His Ala Ala Gln Leu Leu 
        755                 760                 765             


Gln Glu Gln Leu Gln Val Ser Arg Gly Leu Asp Asp Arg Thr Arg Gly 
    770                 775                 780                 


Arg Ala Leu Arg Leu Leu Ala Ser Thr Ala Thr Pro Val Leu Arg Arg 
785                 790                 795                 800 


Lys Leu Leu Ser Lys Ala Val Thr Val Leu Gln Ala Cys Ser Asp Gln 
                805                 810                 815     


Gln Glu Leu Ala Arg Ala Leu Ser Asp Thr Ser Gln Thr Leu Pro Gln 
            820                 825                 830         


Thr Gly Asp Ala Pro Arg Ala Arg Leu Phe Val Arg Arg Ala Gly Arg 
        835                 840                 845             


Leu Ala Gln Ala Ser Gly Arg Ala Pro Ala Leu Pro Gln Gln Val Gln 
    850                 855                 860                 


Arg Arg Ser Ala Pro Ser Asp Ala Ala Pro Thr Gly Gly Ser Ser Ser 
865                 870                 875                 880 


Asp Ala Ser Ser Asp Gly Phe Glu Ser Arg Asp Gln Asp Gly Leu Leu 
                885                 890                 895     


Ser Glu Ala Glu Arg Arg Val Ala Val Leu Ala Ala Arg Gly Arg Thr 
            900                 905                 910         


Asn Arg Gln Ile Ser Asn Glu Leu Tyr Ile Thr Val Ser Thr Val Glu 
        915                 920                 925             


Gln His Leu Thr Arg Val Tyr Arg Lys Leu Asp Val Lys Ser Arg Thr 
    930                 935                 940                 


Asp Leu Pro Asn Arg Leu Met Ala Leu Ala Glu Pro Met Ala 
945                 950                 955             


<210>  2
<211>  2877
<212>  DNA
<213>  Streptomyces ambofaciens

<400>  2
atgctggtcc atcgagacga acaactggcc catctacgct gggcgttcca cgcctgtgag       60

aagcacggac acggacaggt ggcgctggtc accggcgctg tgggcagcgg taagacccag      120

gtgctggaga ccttcgggga gtgggctgcc accgccggtg ggcaggtgct gagcgccgcc      180

gggtcacgcg ccgagcaggg actccatttc ggagtgctcg ggcaactcct gcacagcgcg      240

cggctcaaac cggaggggat ccgggaggtc gaggagctga tacgcgaggt cgcgctggcg      300

gtgcccacgg cggaggcccg aagcggcgcg gcgcccgaga ccttagccga ggccctgaca      360

gcggacgggc tctgggcgcc actgctgcgg accgccttcg acacgttcct gaccctggcc      420

ggccgagggc ctctggtgct ggcggtcgac gacctccagc acacggacgc cgcctcactg      480

cactgtctgc tctacgtcac ccgaagactc agaaacgcac gcatcatggt gctgctctcg      540

gaggcgacga cgctgcgtcc ggcgcatccg ctcttccacg cggagctgcg cagcctgcct      600

cgcttcaccc gggtcaccct gccgctcctc accgccgact ccgtctcccg gctgctcggc      660

gaggaggccg ggacacccga cgtacgcggc gacggggccg gggcaccgga cgtacgcgag      720

gaggccgggc ggatcctgag ggtgaccggc ggcaatccgc tgctgtccca ggcgctggtc      780

gacgaacggg cccaccgcgg gacggacagc gcccccgata ccggagcgag ggccggcgac      840

accttcgaga gggccgtgct cgactgcctc tatcgccacg agccgggcgt tcgcctggtg      900

gcccaggcgc tcgccgcgct ggaccgcccg gcctcaccgg agctgctcgg tcaactgctc      960

gacgtgctgc ccgactccac cgtgcccgcc gtccgcgtcc tcgagggcgc ggggctcgtc     1020

cacgcgggcc ggctgcgcca tccacggatc gtgctcgcgg tgcgttccga catgccggcc     1080

gaggaacggc ggcggctgca ccagcgggcg gccgaggtgt tgcacgagaa cggtgcggaa     1140

gcgagcgtgg tcgccgagca tctggtggcc tcggcgtgga cggacggtgc ctgggtggtg     1200

cccgtcctcc gggacgccgc ggcgcacgcg ctgtccaccg gccgccccga ccacgccgcc     1260

gcgtgtctgc gcctgggcgg tcgagccgag accgacaagg accggcgcaa ctctctgatg     1320

gcgatgctga tcaccgcccg gtggcaggtg aatccgctgg ccgtgaccgg tcaggtgagt     1380

cagttggtgg aggcggcgcg ggccgacgag tcgtcccctt ccacggccgt gtccgcggtg     1440

ccgtacctgt tgtggcaggg acgggcggag gaggcggccg aggcgatcag cggttgtggt     1500

gcgggcgacc acggccccgc gtcgaacgag ctgcggctga cccgcctgct gatcgcgctg     1560

tcccatccgg actacctggg gacggtacgg gaggacccga gctcctggac gcgggcggcg     1620

acggcaccgg actccgccag tccgctgctg caggccgtgt cggtgctcgg caacgcgctg     1680

atgccgaccg gcggggtgga caccgtggcc gccgcggagc agctgctgga gcggcatcat     1740

acggacagtg gctccctggg tctgttgacc gcccccctcc tggcgttgct ctgtgccggc     1800

cccgccgacc gggtcgcggt ctggggcgaa cggctgctgg cacgacaggg tgtccagcac     1860

acaccggcct ggcggggtgt catacgggcg atccacgcgg aagcgacgct gcggctggga     1920

gacatggacg cggcggagcg gggcgcgcgg ttggcgctgg aggatctgcc cgcgcctgcg     1980

tggggcgtgg ccgtcggtgg tcccctgggc accctgatca cctgcacgac cgagagtggc     2040

cggctgttcg aggccgaacg ctggctgtcg cagccggtac cggccggcgt cttccgcact     2100

ccggtgggcg cccactatct gatcgcccgg ggccggcacc atctggccat gggacagcac     2160

caggcggccg cggccgatct gcaccgcagc ggtgagttgg tccgttcctg gggcatcgac     2220

gtggccggac tggttccgtg gcgcctggag ctggcccggg tacagctcag cctcggccac     2280

agaacgcacg ccgcgcaact gctgcaggag cagctgcagg tgtcccgcgg gctggacgac     2340

cgtactcgcg ggcgggcgct gcggctgctg gcttccacgg ccacgccggt tctgcggcgc     2400

aagctgctgt ccaaggcggt gaccgtgttg caggcatgca gtgaccagca ggagctggcc     2460

cgggccctgt ccgacacgag tcagacgctc ccacagaccg gtgacgcccc acgggcccgg     2520

ctgttcgtac gtcgcgccgg ccggctggca caggcctcgg gccgggctcc agcgctgccg     2580

cagcaggtgc agcgacggtc cgcgcccagc gacgcggcgc cgacgggggg ttcctcctcg     2640

gatgcgtctt cggacggctt cgagtcccgg gatcaggacg gtctgctgag cgaggccgag     2700

cgaagggtcg cggtactggc ggcacggggg cgtaccaacc ggcagatctc caacgagctc     2760

tacatcacgg tgagtacggt ggagcagcac ctcacccggg tgtaccggaa gctggacgtc     2820

aagagccgca cggacctgcc gaaccggctc atggcccttg ccgagccgat ggcctag        2877


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  3
aggtctagag tcagccgagg aaac                                              24


<210>  4
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  4
catatgacga acgtgtcacg cgcgc                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  5
catatgctgg tccatcgaga cgaac                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  6
tctagactct gctctctcca aggct                                             25


<210>  7
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  7
cgcggcatgc tcttcct                                                      17


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  8
aggtggcgta cgtggagaac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  9
gtcgccggat caccgaggaa                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  10
aggtcgcgga acgccttgtc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  11
tgcctgcggt gctccaccaa                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  12
cgtcgtcttc tcctccatcg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  13
accgcgccgg aggtgagaca                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  14
gctgctcgcc tgcgtggaca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  15
ggaacagctc gccgtactcc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  16
ccgaactcgt cggcgtatgg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  17
ctggagacct tcggggagtg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotides derived from S. ambofaciens DNA

<400>  18
tgcccgagca ctccgaaatg                                                   20


