                         SEQUENCE LISTING

<110>  The Salk Institute for Biological Studies
       Noel, Joseph P.
       Dellas, Nikki M.
 
<120>  METHODS AND COMPOSITION FOR ISOPRENOID DIPHOSPHATE SYNTHESIS

<130>  027731-002110PC

<150>  US 61/226,582
<151>  2009-07-17

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  260
<212>  PRT
<213>  Methanocaldococcus jannaschii

<400>  1

Met Leu Thr Ile Leu Lys Leu Gly Gly Ser Ile Leu Ser Asp Lys Asn 
1               5                   10                  15      


Val Pro Tyr Ser Ile Lys Trp Asp Asn Leu Glu Arg Ile Ala Met Glu 
            20                  25                  30          


Ile Lys Asn Ala Leu Asp Tyr Tyr Lys Asn Gln Asn Lys Glu Ile Lys 
        35                  40                  45              


Leu Ile Leu Val His Gly Gly Gly Ala Phe Gly His Pro Val Ala Lys 
    50                  55                  60                  


Lys Tyr Leu Lys Ile Glu Asp Gly Lys Lys Ile Phe Ile Asn Met Glu 
65                  70                  75                  80  


Lys Gly Phe Trp Glu Ile Gln Arg Ala Met Arg Arg Phe Asn Asn Ile 
                85                  90                  95      


Ile Ile Asp Thr Leu Gln Ser Tyr Asp Ile Pro Ala Val Ser Ile Gln 
            100                 105                 110         


Pro Ser Ser Phe Val Val Phe Gly Asp Lys Leu Ile Phe Asp Thr Ser 
        115                 120                 125             


Ala Ile Lys Glu Met Leu Lys Arg Asn Leu Val Pro Val Ile His Gly 
    130                 135                 140                 


Asp Ile Val Ile Asp Asp Lys Asn Gly Tyr Arg Ile Ile Ser Gly Asp 
145                 150                 155                 160 


Asp Ile Val Pro Tyr Leu Ala Asn Glu Leu Lys Ala Asp Leu Ile Leu 
                165                 170                 175     


Tyr Ala Thr Asp Val Asp Gly Val Leu Ile Asp Asn Lys Pro Ile Lys 
            180                 185                 190         


Arg Ile Asp Lys Asn Asn Ile Tyr Lys Ile Leu Asn Tyr Leu Ser Gly 
        195                 200                 205             


Ser Asn Ser Ile Asp Val Thr Gly Gly Met Lys Tyr Lys Ile Glu Met 
    210                 215                 220                 


Ile Arg Lys Asn Lys Cys Arg Gly Phe Val Phe Asn Gly Asn Lys Ala 
225                 230                 235                 240 


Asn Asn Ile Tyr Lys Ala Leu Leu Gly Glu Val Glu Gly Thr Glu Ile 
                245                 250                 255     


Asp Phe Ser Glu 
            260 


<210>  2
<211>  266
<212>  PRT
<213>  Streptomyces wedmorensis

<400>  2

Met Thr Pro Asp Phe Leu Ala Ile Lys Val Gly Gly Ser Leu Phe Ser 
1               5                   10                  15      


Arg Lys Asp Glu Pro Gly Ser Leu Asp Asp Asp Ala Val Thr Arg Phe 
            20                  25                  30          


Ala Arg Asn Phe Ala Arg Leu Ala Glu Thr Tyr Arg Gly Arg Met Val 
        35                  40                  45              


Leu Ile Ser Gly Gly Gly Ala Phe Gly His Gly Ala Ile Arg Asp His 
    50                  55                  60                  


Asp Ser Thr His Ala Phe Ser Leu Ala Gly Leu Thr Glu Ala Thr Phe 
65                  70                  75                  80  


Glu Val Lys Lys Arg Trp Ala Glu Lys Leu Arg Gly Ile Gly Val Asp 
                85                  90                  95      


Ala Phe Pro Leu Gln Leu Ala Ala Met Cys Thr Leu Arg Asn Gly Ile 
            100                 105                 110         


Pro Gln Leu Arg Ser Glu Val Leu Arg Asp Val Leu Asp His Gly Ala 
        115                 120                 125             


Leu Pro Val Leu Ala Gly Asp Ala Leu Phe Asp Glu His Gly Lys Leu 
    130                 135                 140                 


Trp Ala Phe Ser Ser Asp Arg Val Pro Glu Val Leu Leu Pro Met Val 
145                 150                 155                 160 


Glu Gly Arg Leu Arg Val Val Thr Leu Thr Asp Val Asp Gly Ile Val 
                165                 170                 175     


Thr Asp Gly Ala Gly Gly Asp Thr Ile Leu Pro Glu Val Asp Ala Arg 
            180                 185                 190         


Ser Pro Glu Gln Ala Tyr Ala Ala Leu Trp Gly Ser Ser Glu Trp Asp 
        195                 200                 205             


Ala Thr Gly Ala Met His Thr Lys Leu Asp Ala Leu Val Thr Cys Ala 
    210                 215                 220                 


Arg Arg Gly Ala Glu Cys Phe Ile Met Arg Gly Asp Pro Gly Ser Asp 
225                 230                 235                 240 


Leu Glu Phe Leu Thr Ala Pro Phe Ser Ser Trp Pro Ala His Val Arg 
                245                 250                 255     


Ser Thr Arg Ile Thr Thr Thr Ala Ser Ala 
            260                 265     


<210>  3
<211>  248
<212>  PRT
<213>  Chlamydophila pneumoniae

<400>  3

Met Ala Lys Gln Thr Arg Arg Val Leu Phe Lys Ile Ser Gly Glu Ala 
1               5                   10                  15      


Leu Ser Lys Asp Ser Ser Asn Arg Ile Asp Glu Met Arg Leu Ser Arg 
            20                  25                  30          


Leu Val Ser Glu Leu Arg Ala Val Arg Asn Asn Asp Ile Glu Ile Ala 
        35                  40                  45              


Leu Val Ile Gly Gly Gly Asn Ile Leu Arg Gly Leu Ala Glu Gln Lys 
    50                  55                  60                  


Glu Leu Gln Ile Asn Arg Val Ser Ala Asp Gln Met Gly Met Leu Ala 
65                  70                  75                  80  


Thr Leu Ile Asn Gly Met Ala Val Ala Asp Ala Leu Lys Ala Glu Asp 
                85                  90                  95      


Ile Pro Cys Leu Leu Thr Ser Thr Leu Ser Cys Pro Gln Leu Ala Asp 
            100                 105                 110         


Leu Tyr Thr Pro Gln Lys Ser Ile Glu Ala Leu Asp Gln Gly Lys Ile 
        115                 120                 125             


Leu Ile Cys Thr Thr Gly Ala Gly Ser Pro Tyr Leu Thr Thr Asp Thr 
    130                 135                 140                 


Gly Ala Ala Leu Arg Ala Cys Glu Leu Asn Val Asp Val Leu Ile Lys 
145                 150                 155                 160 


Ala Thr Met His Val Asp Gly Val Tyr Asp Lys Asp Pro Arg Leu Phe 
                165                 170                 175     


Pro Asp Ala Val Lys Tyr Asp Phe Val Ser Tyr Lys Asp Phe Leu Ser 
            180                 185                 190         


Asn Gln Leu Gly Val Met Asp Ala Ser Ala Ile Ser Leu Cys Met Asp 
        195                 200                 205             


Ser His Ile Pro Ile Arg Val Phe Ser Phe Leu Gln His Ser Leu Glu 
    210                 215                 220                 


Lys Ala Leu Phe Asp Pro Thr Ile Gly Thr Leu Val Ser Glu Asp Val 
225                 230                 235                 240 


Asn His Val Cys Ser Pro Arg His 
                245             


<210>  4
<211>  241
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ala Thr Asn Ala Lys Pro Val Tyr Lys Arg Ile Leu Leu Lys Leu 
1               5                   10                  15      


Ser Gly Glu Ala Leu Gln Gly Thr Glu Gly Phe Gly Ile Asp Ala Ser 
            20                  25                  30          


Ile Leu Asp Arg Met Ala Gln Glu Ile Lys Glu Leu Val Glu Leu Gly 
        35                  40                  45              


Ile Gln Val Gly Val Val Ile Gly Gly Gly Asn Leu Phe Arg Gly Ala 
    50                  55                  60                  


Gly Leu Ala Lys Ala Gly Met Asn Arg Val Val Gly Asp His Met Gly 
65                  70                  75                  80  


Met Leu Ala Thr Val Met Asn Gly Leu Ala Met Arg Asp Ala Leu His 
                85                  90                  95      


Arg Ala Tyr Val Asn Ala Arg Leu Met Ser Ala Ile Pro Leu Asn Gly 
            100                 105                 110         


Val Cys Asp Ser Tyr Ser Trp Ala Glu Ala Ile Ser Leu Leu Arg Asn 
        115                 120                 125             


Asn Arg Val Val Ile Leu Ser Ala Gly Thr Gly Asn Pro Phe Phe Thr 
    130                 135                 140                 


Thr Asp Ser Ala Ala Cys Leu Arg Gly Ile Glu Ile Glu Ala Asp Val 
145                 150                 155                 160 


Val Leu Lys Ala Thr Lys Val Asp Gly Val Phe Thr Ala Asp Pro Ala 
                165                 170                 175     


Lys Asp Pro Thr Ala Thr Met Tyr Glu Gln Leu Thr Tyr Ser Glu Val 
            180                 185                 190         


Leu Glu Lys Glu Leu Lys Val Met Asp Leu Ala Ala Phe Thr Leu Ala 
        195                 200                 205             


Arg Asp His Lys Leu Pro Ile Arg Val Phe Asn Met Asn Lys Pro Gly 
    210                 215                 220                 


Ala Leu Arg Arg Val Val Met Gly Glu Lys Glu Gly Thr Leu Ile Thr 
225                 230                 235                 240 


Glu 
    


<210>  5
<211>  242
<212>  PRT
<213>  Rickettsia prowazekii

<400>  5

Met Ala Ser Asp Ile Asn Ala Leu Lys Tyr Lys Lys Val Leu Leu Lys 
1               5                   10                  15      


Val Ser Gly Glu Ala Leu Met Gly Asn Lys Gln Phe Gly His Glu Tyr 
            20                  25                  30          


Glu Val Ile Lys Lys Ile Ala Glu Asp Ile Lys Glu Val Ile Asp Leu 
        35                  40                  45              


Gly Leu Glu Val Ala Ile Val Val Gly Gly Gly Asn Ile Tyr Arg Gly 
    50                  55                  60                  


Ile Asn Ala Ala Leu Val Gly Met Asp Arg Ala Ser Ala Asp Tyr Ile 
65                  70                  75                  80  


Gly Met Leu Ala Thr Val Met Asn Ala Leu Thr Leu Gln Asn Val Met 
                85                  90                  95      


Glu Ser Leu Gly Ile Tyr Thr Arg Val Leu Ser Ala Ile Pro Met Met 
            100                 105                 110         


Ser Val Cys Glu Pro Tyr Ile Arg Arg Lys Ala Lys Arg His Met Glu 
        115                 120                 125             


Lys Lys Arg Val Val Ile Phe Ala Gly Gly Thr Gly Asn Pro Phe Cys 
    130                 135                 140                 


Thr Thr Asp Ser Ala Ala Val Leu Arg Ala Ile Glu Met Asn Cys Asp 
145                 150                 155                 160 


Ile Leu Leu Lys Ala Thr Gln Val Asp Gly Val Tyr Asp Ser Asp Pro 
                165                 170                 175     


Lys Lys Asn Pro Asn Ala Lys Lys Tyr Phe Thr Ile Ser Tyr Lys Asp 
            180                 185                 190         


Val Ile Asn Asn His Leu Gln Val Met Asp Thr Ala Ala Ile Ala Val 
        195                 200                 205             


Ala Arg Glu Asn Lys Leu Pro Ile Arg Val Phe Ser Ile Lys Glu His 
    210                 215                 220                 


Gly Asn Phe Ala Arg Val Ile Gln Asp Lys Gly Gln Tyr Thr Thr Ile 
225                 230                 235                 240 


Gly Glu 
        


<210>  6
<211>  240
<212>  PRT
<213>  Aquifex aeolicus

<400>  6

Met Glu Glu Lys Pro Lys Tyr Lys Arg Ile Leu Leu Lys Leu Ser Gly 
1               5                   10                  15      


Glu Ala Phe Ala Gly Glu Gln Gly Tyr Gly Ile Asp Pro Ala Phe Leu 
            20                  25                  30          


Glu Tyr Ile Ser His Glu Ile Lys Asn Val Tyr Asp Leu Gly Val Gln 
        35                  40                  45              


Val Ala Ile Val Ile Gly Gly Gly Asn Ile Phe Arg Gly Phe Gln Gly 
    50                  55                  60                  


Lys Glu Ile Gly Val Asp Arg Ala Thr Ala Asp Tyr Met Gly Met Leu 
65                  70                  75                  80  


Ala Thr Val Ile Asn Ala Leu Ala Leu Gln Ser Ala Leu Glu Asn His 
                85                  90                  95      


Val Asn Ile Pro Thr Arg Val Leu Ser Ala Ile Glu Met Arg Gln Val 
            100                 105                 110         


Ala Glu Pro Tyr Ile Arg Arg Arg Ala Ile Arg His Leu Glu Lys Gly 
        115                 120                 125             


Arg Ile Val Ile Phe Ala Gly Gly Thr Gly Asn Pro Phe Phe Ser Thr 
    130                 135                 140                 


Asp Thr Ala Ala Ala Leu Arg Ala Ala Glu Ile Gly Ala Glu Val Leu 
145                 150                 155                 160 


Ile Lys Ala Thr Lys Val Gly Gly Ile Tyr Asp Lys Asp Pro Glu Lys 
                165                 170                 175     


Tyr Pro Asp Ala Val Leu Ile Lys Glu Ile Ser Tyr Leu Glu Val Ile 
            180                 185                 190         


Asn Met Gly Leu Lys Val Met Asp His Thr Ala Leu Thr Leu Cys Lys 
        195                 200                 205             


Glu Asn Glu Ile Pro Ile Ile Val Leu Asn Val Lys Glu Lys Gly Asn 
    210                 215                 220                 


Leu Arg Arg Ala Val Leu Gly Glu Glu Val Gly Ser Val Val Arg Gly 
225                 230                 235                 240 


<210>  7
<211>  260
<212>  PRT
<213>  Unknown

<220>
<223>  Synechocystis species

<400>  7

Met Gly Gly Ile Leu Arg Leu Thr Leu Ile Pro Cys Leu Tyr Ile Asn 
1               5                   10                  15      


Gly Asp Gly Gly Met Ser Tyr Gln Arg Val Leu Leu Lys Leu Ser Gly 
            20                  25                  30          


Glu Ala Leu Met Gly Asp Leu Gly Tyr Gly Ile Asp Pro Ala Val Val 
        35                  40                  45              


Gly Thr Ile Ala Gln Glu Ile Lys Asp Val Leu Gln Ala Gly Val Gln 
    50                  55                  60                  


Leu Ala Ile Val Val Gly Gly Gly Asn Ile Phe Arg Gly Val Lys Ala 
65                  70                  75                  80  


Ser Ala Ala Gly Met Asp Arg Ala Thr Ala Asp Tyr Ile Gly Met Ile 
                85                  90                  95      


Ala Thr Val Met Asn Ala Met Thr Leu Gln Asp Ala Leu Glu Gln Met 
            100                 105                 110         


Asp Ile Pro Thr Arg Val Leu Thr Ala Ile Ala Met Gln Glu Val Ala 
        115                 120                 125             


Glu Pro Tyr Ile Arg Arg Arg Ala Ile Arg His Leu Glu Lys Gly Arg 
    130                 135                 140                 


Val Val Ile Phe Gly Ala Gly Ser Gly Asn Pro Phe Phe Thr Thr Asp 
145                 150                 155                 160 


Thr Thr Ala Ala Leu Arg Ala Ala Glu Ile Asp Ala Glu Val Val Phe 
                165                 170                 175     


Lys Ala Thr Lys Val Asp Gly Val Tyr Asp Ser Asp Pro Lys Thr Asn 
            180                 185                 190         


Pro Asn Ala Arg Arg Phe Thr Thr Leu Thr Tyr Ser His Val Leu Ala 
        195                 200                 205             


Glu Asp Leu Lys Val Met Asp Ser Thr Ala Ile Ala Leu Cys Lys Asp 
    210                 215                 220                 


Asn Asn Ile Pro Ile Met Ile Phe Asp Leu Gly Val Pro Gly Asn Ile 
225                 230                 235                 240 


Val Arg Ala Ile Lys Gly Glu Ala Val Gly Thr Leu Val Gly Glu Asn 
                245                 250                 255     


Cys Glu Val Ser 
            260 


<210>  8
<211>  256
<212>  PRT
<213>  Methanococcus maripaludis

<400>  8

Met Phe Ala Ile Leu Lys Leu Gly Gly Ser Ile Leu Cys Asp Lys Asn 
1               5                   10                  15      


Val Pro Tyr Ser Ile Asn Trp Glu Asn Leu Glu Asn Ile Ala Ile Glu 
            20                  25                  30          


Ile Lys Glu Ala Ile Glu Tyr Tyr Ser Ser Lys Asn Glu Asp Phe Lys 
        35                  40                  45              


Leu Ile Ile Val His Gly Gly Gly Ser Phe Gly His Pro Val Ala Lys 
    50                  55                  60                  


Lys Tyr Leu Lys Asn Glu Lys Phe Glu Asp Met Gly Lys Gly Tyr Trp 
65                  70                  75                  80  


Glu Ile Gln Lys Ala Met Arg Lys Phe Asn Asn Ile Val Ile Glu Glu 
                85                  90                  95      


Leu Gln Asn Phe Glu Pro Ala Val Ser Ile Gln Ala Ser Ser Phe Ile 
            100                 105                 110         


Thr Phe Asn His Lys Ser Asn Leu His Phe Asp Thr Asn Ala Ile Glu 
        115                 120                 125             


Lys Met Leu Asp Lys Gly Leu Ile Pro Val Ile His Gly Asp Ile Val 
    130                 135                 140                 


Ile Asp Glu Lys Thr Asp Asn Phe Lys Ile Phe Ser Gly Asp His Ala 
145                 150                 155                 160 


Leu Pro Phe Leu Ser Lys Lys Leu Asn Pro Asp Leu Ser Leu His Ala 
                165                 170                 175     


Ser Asp Val Asp Gly Val Trp Asp Ser Glu Phe Lys Ile Ile Glu Asn 
            180                 185                 190         


Ile Asn Ser Lys Asn Ile Glu Asp Val Leu Lys Ser Leu Lys Pro Ser 
        195                 200                 205             


Asn Lys Glu Asp Val Thr Gly Gly Met His Leu Lys Val Met Glu Cys 
    210                 215                 220                 


Tyr Asn Leu Gly Ile Glu Thr Ile Ile Phe Asn Gly Asn Lys Lys Arg 
225                 230                 235                 240 


Asn Ile Tyr Asn Ala Leu Leu Lys Asn Val Lys Gly Thr Leu Ile Asn 
                245                 250                 255     


<210>  9
<211>  281
<212>  PRT
<213>  Trichoplax adhaearens

<400>  9

Met Ala Leu Glu Asn Arg His Val Asp Cys Ile Ile Lys Leu Gly Gly 
1               5                   10                  15      


Ser Ala Ile Thr Ser Lys Gln His Leu Glu Lys Ala Asn Thr Gln Ala 
            20                  25                  30          


Ile Asn Ile Ala Ala Ser His Val His Glu Met Thr Arg Lys Cys Val 
        35                  40                  45              


Ile Val His Gly Ala Gly Ser Phe Gly His Phe His Ala Lys Lys Tyr 
    50                  55                  60                  


Asn Ile Ala Thr Gly Phe Asn Asp Thr Asp Phe Glu Gln Gln Arg Ile 
65                  70                  75                  80  


Gly Phe Ser Gln Thr Arg Leu Ser Val Thr Lys Leu Asn His Ile Ile 
                85                  90                  95      


Val Gln Ala Leu Ile Glu Lys Asp Val Pro Ala Val Ser Ile Ser Pro 
            100                 105                 110         


Cys Gly Leu Trp Lys Thr Thr Asp Arg Ser Val Thr Ser Thr Phe Leu 
        115                 120                 125             


Gln Pro Ile Asn Asp Leu Leu Arg Ala Gly Phe Val Pro Val Val His 
    130                 135                 140                 


Gly Asp Ala Val Ile Asp Thr Ser Leu Gly Cys Thr Ile Leu Ser Gly 
145                 150                 155                 160 


Asp Thr Ile Ile Gln Ile Leu Ala Glu Asn Leu Cys Pro Lys Arg Ile 
                165                 170                 175     


Ile Phe Ile Thr Asp Thr Asn Gly Ile Tyr Asp Arg Pro Pro His Asn 
            180                 185                 190         


Asp Asp Ala Lys Leu Leu Arg Tyr Ile Ser Val Thr Lys Asp Gly Lys 
        195                 200                 205             


Val Thr Asn Glu Ile Glu Thr Ser Gln Leu Glu His Asp Val Thr Gly 
    210                 215                 220                 


Gly Val Gln Thr Lys Ile Ala Ser Ala Ala His Ile Val Ser Lys Cys 
225                 230                 235                 240 


Asn Ile Pro Val His Val Val Lys Leu Gly Ser Ala Ala Ala Trp Lys 
                245                 250                 255     


Leu Leu Asp Lys Gly Glu Leu Glu Glu Ser Asp Ile Ala Thr Thr Ile 
            260                 265                 270         


Thr Leu Gln Glu Ser Glu Tyr Pro Lys 
        275                 280     


<210>  10
<211>  332
<212>  PRT
<213>  Arabidopsis thaliana

<400>  10

Met Glu Leu Asn Ile Ser Glu Ser Arg Ser Arg Ser Ile Arg Cys Ile 
1               5                   10                  15      


Val Lys Leu Gly Gly Ala Ala Ile Thr Cys Lys Asn Glu Leu Glu Lys 
            20                  25                  30          


Ile His Asp Glu Asn Leu Glu Val Val Ala Cys Gln Leu Arg Gln Ala 
        35                  40                  45              


Met Leu Glu Gly Ser Ala Pro Ser Lys Val Ile Gly Met Asp Trp Ser 
    50                  55                  60                  


Lys Arg Pro Gly Ser Ser Glu Ile Ser Cys Asp Val Asp Asp Ile Gly 
65                  70                  75                  80  


Asp Gln Lys Ser Ser Glu Phe Ser Lys Phe Val Val Val His Gly Ala 
                85                  90                  95      


Gly Ser Phe Gly His Phe Gln Ala Ser Arg Ser Gly Val His Lys Gly 
            100                 105                 110         


Gly Leu Glu Lys Pro Ile Val Lys Ala Gly Phe Val Ala Thr Arg Ile 
        115                 120                 125             


Ser Val Thr Asn Leu Asn Leu Glu Ile Val Arg Ala Leu Ala Arg Glu 
    130                 135                 140                 


Gly Ile Pro Thr Ile Gly Met Ser Pro Phe Ser Cys Gly Trp Ser Thr 
145                 150                 155                 160 


Ser Lys Arg Asp Val Ala Ser Ala Asp Leu Ala Thr Val Ala Lys Thr 
                165                 170                 175     


Ile Asp Ser Gly Phe Val Pro Val Leu His Gly Asp Ala Val Leu Asp 
            180                 185                 190         


Asn Ile Leu Gly Cys Thr Ile Leu Ser Gly Asp Val Ile Ile Arg His 
        195                 200                 205             


Leu Ala Asp His Leu Lys Pro Glu Tyr Val Val Phe Leu Thr Asp Val 
    210                 215                 220                 


Leu Gly Val Tyr Asp Arg Pro Pro Ser Pro Ser Glu Pro Asp Ala Val 
225                 230                 235                 240 


Leu Leu Lys Glu Ile Ala Val Gly Glu Asp Gly Ser Trp Lys Val Val 
                245                 250                 255     


Asn Pro Leu Leu Glu His Thr Asp Lys Lys Val Asp Tyr Ser Val Ala 
            260                 265                 270         


Ala His Asp Thr Thr Gly Gly Met Glu Thr Lys Ile Ser Glu Ala Ala 
        275                 280                 285             


Met Ile Ala Lys Leu Gly Val Asp Val Tyr Ile Val Lys Ala Ala Thr 
    290                 295                 300                 


Thr His Ser Gln Arg Ala Leu Asn Gly Asp Leu Arg Asp Ser Val Pro 
305                 310                 315                 320 


Glu Asp Trp Leu Gly Thr Ile Ile Arg Phe Ser Lys 
                325                 330         


<210>  11
<211>  297
<212>  PRT
<213>  Branchiostoma floridae

<400>  11

Met Val His Lys Cys Cys Leu Cys Gln Cys Thr Asp Val Leu Ser Gly 
1               5                   10                  15      


Leu Glu Cys Ile Val Lys Leu Gly Gly Ser Ala Val Thr Asp Lys Ser 
            20                  25                  30          


Thr Leu Glu Thr Pro Arg Leu Asp Ala Ile Arg Ala Ala Ala Asp Ile 
        35                  40                  45              


Ile Ser Gln Val Arg Gly Arg Cys Ile Val Val His Gly Ala Gly Ser 
    50                  55                  60                  


Phe Gly His Phe Gln Ala Arg Glu His Gly Val Val Trp Gly Tyr Arg 
65                  70                  75                  80  


Asp Lys Glu Thr Asp Thr Glu Val Gln Thr Val Lys Leu Gly Phe Cys 
                85                  90                  95      


Arg Thr Arg Gln Ser Val Thr Lys Leu Leu His Ile Ile Thr Glu Glu 
            100                 105                 110         


Phe Val Arg Leu Gly Ile Pro Ala Val Gly Val Ser Pro Leu Ser Ser 
        115                 120                 125             


Trp Val Thr Asp Asp Ala Ser Val Val Lys Ala Asp Thr Asp Asn Ile 
    130                 135                 140                 


Arg Asp Met Leu Leu Glu Gly Phe Leu Pro Val Met His Gly Asp Ala 
145                 150                 155                 160 


Val Leu Asp Arg Lys Arg Gly Cys Thr Ile Leu Ser Gly Asp Thr Ile 
                165                 170                 175     


Ile Lys His Leu Cys Ser Val Phe Arg Pro Pro Arg Val Val Phe Leu 
            180                 185                 190         


Thr Asp Val Pro Gly Ile Tyr Asp Arg Pro Pro Glu Gln Pro Gly Ala 
        195                 200                 205             


Gln Leu Ile Pro Glu Ile Gln Val Asp Arg Asp Arg Lys Leu His Val 
    210                 215                 220                 


Ser Ile Ala Thr Ser Ser Gln Ala His Asp Val Thr Gly Gly Ile Ala 
225                 230                 235                 240 


Leu Lys Leu Lys Ser Ala Ile Asp Ile Val Thr Glu Ser Asn Gly His 
                245                 250                 255     


Thr Cys Val Met Val Cys Gly Ile Gln Ser Gln Ala Ala Val Arg Ala 
            260                 265                 270         


Cys Val Glu Gly Gln Leu Pro Gln Gly Thr Gly Thr Ile Val Gln Asn 
        275                 280                 285             


Ile Ser Lys His Pro Asp Glu Val Thr 
    290                 295         


<210>  12
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for forward primer for IPK of M. jannaschii

<400>  12
cccatggcgg atccatgcta accatattaa aattaggagg                           40


<210>  13
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for reverse primer for IPK of M. jannaschii

<400>  13
tggtggtgct cgagttattc tgaaaaatca atttctgttc                           40


<210>  14
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for forward primer for IPK of M. maripaludis

<400>  14
gagggcggat caaaattcta acgtttgtaa ggtacccttg gt                        42


<210>  15
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for reverse primer for IPK of M. maripaludis

<400>  15
gtggtgctcg agttaattta ttaatgttcc ttttacattt tt                        42


<210>  16
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for forward primer for IPK of M. jannaschii H60A

<400>  16
cgtccatgga ggaggagctt ttggtgctcc agtagctaaa                           40


<210>  17
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for reverse primer for IPK of M. jannaschii H60A

<400>  17
tttagctact ggagcaccaa aagctcctcc tccatggacg                           40


<210>  18
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for forward primer for IPK of M. jannaschii H60N

<400>  18
atggaggagg agcttttggt aatccagtag ctaaaaaata c                         41


<210>  19
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for reverse primer for IPK of M. jannaschii H60N

<400>  19
gtatttttta gctactggat taccaaaagc tcctcctcca t                         41


<210>  20
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA for forward primer for IPK of M. jannaschii H60Q

<400>  20
catggaggag gagcttttgg tcagccagta gctaaa                               36


<210>  21
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic DNA for reverse primer for IPK of M. jannaschii H60Q

<400>  21

Thr Thr Thr Ala Gly Cys Thr Ala Cys Thr Gly Gly Cys Thr Gly Ala 
1               5                   10                  15      


Cys Cys Ala Ala Ala Ala Gly Cys Thr Cys Cys Thr Cys Cys Thr Cys 
            20                  25                  30          


Cys Ala Thr Gly 
        35      


<210>  22
<211>  258
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Met Asn Pro Leu Ile Ile Lys Leu Gly Gly Val Leu Leu Asp Ser 
1               5                   10                  15      


Glu Glu Ala Leu Glu Arg Leu Phe Ser Ala Leu Val Asn Tyr Arg Glu 
            20                  25                  30          


Ser His Gln Arg Pro Leu Val Ile Val His Gly Gly Gly Cys Val Val 
        35                  40                  45              


Asp Glu Leu Met Lys Gly Leu Asn Leu Pro Val Lys Lys Lys Asn Gly 
    50                  55                  60                  


Leu Arg Val Thr Pro Ala Asp Gln Ile Asp Ile Ile Thr Gly Ala Leu 
65                  70                  75                  80  


Ala Gly Thr Ala Asn Lys Thr Leu Leu Ala Trp Ala Lys Lys His Gln 
                85                  90                  95      


Ile Ala Ala Val Gly Leu Phe Leu Gly Asp Gly Asp Ser Val Lys Val 
            100                 105                 110         


Thr Gln Leu Asp Glu Glu Leu Gly His Val Gly Leu Ala Gln Pro Gly 
        115                 120                 125             


Ser Pro Lys Leu Ile Asn Ser Leu Leu Glu Asn Gly Tyr Leu Pro Val 
    130                 135                 140                 


Val Ser Ser Ile Gly Val Thr Asp Glu Gly Gln Leu Met Asn Val Asn 
145                 150                 155                 160 


Ala Asp Gln Ala Ala Thr Ala Leu Ala Ala Thr Leu Gly Ala Asp Leu 
                165                 170                 175     


Ile Leu Leu Ser Asp Val Ser Gly Ile Leu Asp Gly Lys Gly Gln Arg 
            180                 185                 190         


Ile Ala Glu Met Thr Ala Ala Lys Ala Glu Gln Leu Ile Glu Gln Gly 
        195                 200                 205             


Ile Ile Thr Asp Gly Met Ile Val Lys Val Asn Ala Ala Leu Asp Ala 
    210                 215                 220                 


Ala Arg Thr Leu Gly Arg Pro Val Asp Ile Ala Ser Trp Arg His Ala 
225                 230                 235                 240 


Glu Gln Leu Pro Ala Leu Phe Asn Gly Met Pro Met Gly Thr Arg Ile 
                245                 250                 255     


Leu Ala 
        


