                         SEQUENCE LISTING

<110>  ZIRUS, INC
       Vanderbilt University
       Hodge, Thomas
       Rubin, Donald
       McDonald, Natalie
       Murray, James
 
<120>  MAMMALIAN GENES INVOLVED IN INFECTION

<130>  01123.0026P1

<150>  US 61/270,930
<151>  2009-07-15

<160>  2607  

<170>  PatentIn version 3.5

<210>  1
<211>  4937
<212>  DNA
<213>  Homo sapiens

<400>  1
ctccgcactg ctcactcccg cgcagtgagg ttggcacagc caccgctctg tggctcgctt       60

ggttccctta gtcccgagcg ctcgcccact gcagattcct ttcccgtgca gacatggcct      120

ctggcaccac caccaccgcc gtgaagattg gaataattgg tggaacaggc ctggatgatc      180

cagaaatttt agaaggaaga actgaaaaat atgtggatac tccatttggc aagccatctg      240

atgccttaat tttggggaag ataaaaaatg ttgattgcgt cctccttgca aggcatggaa      300

ggcagcacac catcatgcct tcaaaggtca actaccaggc gaacatctgg gctttgaagg      360

aagagggctg tacacatgtc atagtgacca cagcttgtgg ctccttgagg gaggagattc      420

agcccggcga tattgtcatt attgatcagt tcattgacag gaccactatg agacctcagt      480

ccttctatga tggaagtcat tcttgtgcca gaggagtgtg ccatattcca atggctgagc      540

cgttttgccc caaaacgaga gaggttctta tagagactgc taagaagcta ggactccggt      600

gccactcaaa ggggacaatg gtcacaatcg agggacctcg ttttagctcc cgggcagaaa      660

gcttcatgtt ccgcacctgg ggggcggatg ttatcaacat gaccacagtt ccagaggtgg      720

ttcttgctaa ggaggctgga atttgttacg caagtatcgc catggcgaca gattatgact      780

gctggaagga gcacgaggaa gcagtttcgg tggaccgggt cttaaagacc ctgaaagaaa      840

acgctaataa agccaaaagc ttactgctca ctaccatacc tcagataggg tccacagaat      900

ggtcagaaac cctccataac ctgaagaata tggcccagtt ttctgtttta ttaccaagac      960

attaaagtag catggctgcc caggagaaaa gaagacattc taattccagt cattttggga     1020

attcctgctt aacttgaaaa aaatatggga aagacatgca gctttcatgc ccttgcctat     1080

caaagagtat gttgtaagaa agacaagaca ttgtgtgtat tagagactcc tgaatgattt     1140

agacaacttc aaaatacaga agaaaagcaa atgactagta aacatgtggg aaaaaatatt     1200

acattttaag ggggaaaaaa aaacccacca ttctcttctc cccctattaa atttgcaaca     1260

ataaagggtg gagggtaatc tctactttcc tatactgcca aagaatgtga ggaagaaatg     1320

ggactctttg gttatttatt gatgcgactg taaattggta cagtatttct ggagggcaat     1380

ttggtaaaat gcatcaaaag acttaaaaat acggacgtac tttgtgctgg gaactctaca     1440

tctagcaatt tctctttaaa accatatcag agatgcatac aaagaattat atataaagaa     1500

gggtgtttaa taatgatagt tataataata aataattgaa acaatctgaa tcccttgcaa     1560

ttggaggtaa attatgtctt agttataatt agattgtgaa tcagccaact gaaaatcctt     1620

tttgcatatt tcaatgtcct aaaaagacac ggttgctcta tatatgaagt gaaaaaagga     1680

tatggtagca ttttatagta ctagttttgc tttaaaatgc tatgtaaata tacaaaaaaa     1740

ctagaaagaa atatatataa ccttgttatt gtatttgggg gagggatact gggataattt     1800

ttattttctt tgaatctttc tgtgtcttca catttttcta cagtgaattt aatcaaatag     1860

taaagttgtt gtaaaaataa aagtggattt agaaagatcc agttcttgaa aacactgttt     1920

ctggtaatga agcagaattt aagttggtaa tattaaggtg aatgtcattt aagggagtta     1980

catctttatt ctgctaaaga agaggatcat tgatttctgt acagtcagaa cagtacttgg     2040

gtttgcaaca gctttctgag aaaagctagg tgtttaatag tttaactgaa agtttaacta     2100

tttaaaagac taaatgcaca ttttatggta tctgatattt taaaaagtaa tgtttgattc     2160

tcctttttat gagttaaatt attttatacg agttggtaat ttttgctttt taataaagtg     2220

gaagcttgct tttttaactc tttttttatt gttattttat agaaatgctt tttgttggcc     2280

gggcacagtt gctcatccat gtaatcccag cactgtggga ggccgagacg ggtggatcac     2340

aaggtcagga gatcgagacc atcctggcta atgcgttgaa actccgtctc tactaaaaat     2400

acaaaaaatt agctgggcgt ggtggtgggc acctgtagtc ccagctactc aggaggctga     2460

ggcaggagaa tggtgtgaac ctgggaggtg gagcttgcag tgagcagagc ttgcagtgag     2520

acgagcttgt gccactgcac tccagcctgg gcaacagagt aagactcagt ctcaaaaaaa     2580

aaaaaaagag tgaaatgctt tttgtttgct tcagtttttt atcatgggga gatctttttc     2640

ctcagaattg ttttcttttc actgtaggct attacaggat acttcaggat caagatacag     2700

aaccttttat ttaaagagtt tgtaaagtca atgtgtttgt ttgtgtctct gagattgact     2760

tcaagataat aagctgctaa ttgtaaacaa aacagttacc ctccagtatt aatatgactc     2820

attagtgtga gccatttggg tcaagtatga ttatgaccct tggacttcct gatgtagtat     2880

taaatttcaa ctctggttat ccattagcaa tctgtagaga acttaatgaa cctgaaccca     2940

ggcttctcta gctctggtaa cgtgtgattg ttttcactac aatatgatac atagatggta     3000

ccttactttt cctcattctt aataggtgtc taagaatgtc agggcaaaag tatgggcatt     3060

tttcttgcta tgttcagaaa gtacagttct ctccaacttg cagaggtact tttcttgatt     3120

aaatagcctt ctctagcaac atcattttca gactaactaa atgaatgcag tatactcttt     3180

tctttgttct caatcattca ctccttatgc aaagccaata taattttcct cataccttat     3240

gcttgaggat attgttgaag aacacttcct ggaacacttc tcacttgtga tgctgtacta     3300

attttttttt tttaatttaa gctagtatac taagtgaaca ccatggtcag ttgtgagcat     3360

tttggtttcc gcaaaggatg gatggtgagc atcatgggaa agctgtagtt tagtgactta     3420

gcccttagtg attaatagat ttgcatgtac atagaagtct ttgttggcct tataatctgc     3480

tgttatattt ggcatggatt ttcatggttt tgagaatgac atcctggccc tgtggtcccc     3540

gagggtcatg gtccttgtga cctggcccct gttcactgcc cccttcgcta gcacgagttg     3600

ctgtgcaggg ctggaggtag ctaccatggc ttgtttcaag gaaggaaact ctggtacggt     3660

ggcaccctca ggagtggagg acagtgaact tccttgaaga gggagtgact aaggtgacct     3720

ccaacctgcc ctgagccagc tgccctgcag gtgccacgtg agcctgctct ggcatccaca     3780

ggatgctcct ggagcctctt ctctggctgc tacctcaggg catggttgtg gccccaccaa     3840

cacctatttt ccaaataatt attcattctt gtgacagtgg cctgaacatg tttttaattt     3900

tctcaacaag catttagcca gcacttatcc agtgaaacaa tttgataagg tttcaaggag     3960

tatctgatgg gttaggaagt cacgaaatga ggagttcttg ccacatttgc agagtccctc     4020

cttgataagg tttggcggtg tccccaccca aatctcatgt tgaattgtag ttcccataat     4080

ccccacatgt tgtgggaggg acccagtggg aggtaattaa atcatggggg tggttacccc     4140

cacactgctg ttctcatgat actgagttct cacaagtcct gtttgtttta taaggggctt     4200

ttcccccttt tgctcaacac ttcttcctgc catcatgtga agaaggacgt gtttgtttcc     4260

ccttctgcca cgattgtaag tttcctgagg ccttcccagc tatgtggaac tgtgagttaa     4320

ttaaacctct ttcctttata aattacccag tcatgggcag tcctttacag cagcatgaga     4380

atggactaat acactcctca aatgttttga agattgttgc accttggaac taccagtgtg     4440

cacacaatct ggctcaatgt atatattggc ccagcaaggc aaagaactga agttccagga     4500

tggaagaacc tgtgttctcc tcataatagt atagaataat tcaagatagg caagaaggac     4560

agcagtaaat gaagaccatg gaagaaaaga aggaatgcca aagatcgagg aaatctacca     4620

agactagtag ggtagtccag aagaagctgt ttcagggcct gttgccagct atgcctttga     4680

gaacctcggg atcccaaaga atgaggggaa tttcttcaga aagacaatct cggcatgcat     4740

tatttctttg ttttgaagat tcactcatgt tgcatgcatc tgtagcttgt gcctttttta     4800

ttgcctagta gtattctgtc atatgcctat cttacaattt gattatctat tcacctgttg     4860

atgaatgttt gaattttttc catttgagga attttatgaa taaagctgct ataagcatga     4920

aaaaaaaaaa aaaaaaa                                                    4937


<210>  2
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Gly Thr Thr Thr Thr Ala Val Lys Ile Gly Ile Ile Gly 
1               5                   10                  15      


Gly Thr Gly Leu Asp Asp Pro Glu Ile Leu Glu Gly Arg Thr Glu Lys 
            20                  25                  30          


Tyr Val Asp Thr Pro Phe Gly Lys Pro Ser Asp Ala Leu Ile Leu Gly 
        35                  40                  45              


Lys Ile Lys Asn Val Asp Cys Val Leu Leu Ala Arg His Gly Arg Gln 
    50                  55                  60                  


His Thr Ile Met Pro Ser Lys Val Asn Tyr Gln Ala Asn Ile Trp Ala 
65                  70                  75                  80  


Leu Lys Glu Glu Gly Cys Thr His Val Ile Val Thr Thr Ala Cys Gly 
                85                  90                  95      


Ser Leu Arg Glu Glu Ile Gln Pro Gly Asp Ile Val Ile Ile Asp Gln 
            100                 105                 110         


Phe Ile Asp Arg Thr Thr Met Arg Pro Gln Ser Phe Tyr Asp Gly Ser 
        115                 120                 125             


His Ser Cys Ala Arg Gly Val Cys His Ile Pro Met Ala Glu Pro Phe 
    130                 135                 140                 


Cys Pro Lys Thr Arg Glu Val Leu Ile Glu Thr Ala Lys Lys Leu Gly 
145                 150                 155                 160 


Leu Arg Cys His Ser Lys Gly Thr Met Val Thr Ile Glu Gly Pro Arg 
                165                 170                 175     


Phe Ser Ser Arg Ala Glu Ser Phe Met Phe Arg Thr Trp Gly Ala Asp 
            180                 185                 190         


Val Ile Asn Met Thr Thr Val Pro Glu Val Val Leu Ala Lys Glu Ala 
        195                 200                 205             


Gly Ile Cys Tyr Ala Ser Ile Ala Met Ala Thr Asp Tyr Asp Cys Trp 
    210                 215                 220                 


Lys Glu His Glu Glu Ala Val Ser Val Asp Arg Val Leu Lys Thr Leu 
225                 230                 235                 240 


Lys Glu Asn Ala Asn Lys Ala Lys Ser Leu Leu Leu Thr Thr Ile Pro 
                245                 250                 255     


Gln Ile Gly Ser Thr Glu Trp Ser Glu Thr Leu His Asn Leu Lys Asn 
            260                 265                 270         


Met Ala Gln Phe Ser Val Leu Leu Pro Arg His 
        275                 280             


<210>  3
<211>  6247
<212>  DNA
<213>  Homo sapiens

<400>  3
agtggctggg gagtcccgtc gacgctctgt tccgagagcg tgccccggac cgccagctca       60

gaacaggggc agccgtgtag ccgaacggaa gctgggagca gccgggactg gtggcccgcg      120

cccgagctcc gcaggcggga agcaccctgg atttaggaag tcccgggagc agcgcggcgg      180

cacctccctc acccaagggg ccgcggcgac ggtcacgggg cgcggcgcca ccgtgagcga      240

cccaggccag gattctaaat agacggccca ggctcctcct ccgcccgggc cgcctcacct      300

gcgggcattg ccgcgccgcc tccgccggtg tagacggcac ctgcgccgcc ttgctcgcgg      360

gtctccgccc ctcgcccacc ctcactgcgc caggcccagg cagctcacct gtactggcgc      420

gggctgcgga agcctgcgtg agccgaggcg ttgaggcgcg gcgcccacgc cactgtcccg      480

agaggacgca ggtggagcgg gcgcggcttc gcggaacccg gcgccggccg ccgcagtggt      540

cccagcctac accgggttcc ggggacccgg ccgccagtgc ccggggagta gccgccgccg      600

tcggctgggc accatgaaca gcagcagcgc caacatcacc tacgccagtc gcaagcggcg      660

gaagccggtg cagaaaacag taaagccaat cccagctgaa ggaatcaagt caaatccttc      720

caagcggcat agagaccgac ttaatacaga gttggaccgt ttggctagcc tgctgccttt      780

cccacaagat gttattaata agttggacaa actttcagtt cttaggctca gcgtcagtta      840

cctgagagcc aagagcttct ttgatgttgc attaaaatcc tcccctactg aaagaaacgg      900

aggccaggat aactgtagag cagcaaattt cagagaaggc ctgaacttac aagaaggaga      960

attcttatta caggctctga atggctttgt attagttgtc actacagatg ctttggtctt     1020

ttatgcttct tctactatac aagattatct agggtttcag cagtctgatg tcatacatca     1080

gagtgtatat gaacttatcc ataccgaaga ccgagctgaa tttcagcgtc agctacactg     1140

ggcattaaat ccttctcagt gtacagagtc tggacaagga attgaagaag ccactggtct     1200

cccccagaca gtagtctgtt ataacccaga ccagattcct ccagaaaact ctcctttaat     1260

ggagaggtgc ttcatatgtc gtctaaggtg tctgctggat aattcatctg gttttctggc     1320

aatgaatttc caagggaagt taaagtatct tcatggacag aaaaagaaag ggaaagatgg     1380

atcaatactt ccacctcagt tggctttgtt tgcgatagct actccacttc agccaccatc     1440

catacttgaa atccggacca aaaattttat ctttagaacc aaacacaaac tagacttcac     1500

acctattggt tgtgatgcca aaggaagaat tgttttagga tatactgaag cagagctgtg     1560

cacgagaggc tcaggttatc agtttattca tgcagctgat atgctttatt gtgccgagtc     1620

ccatatccga atgattaaga ctggagaaag tggcatgata gttttccggc ttcttacaaa     1680

aaacaaccga tggacttggg tccagtctaa tgcacgcctg ctttataaaa atggaagacc     1740

agattatatc attgtaactc agagaccact aacagatgag gaaggaacag agcatttacg     1800

aaaacgaaat acgaagttgc cttttatgtt taccactgga gaagctgtgt tgtatgaggc     1860

aaccaaccct tttcctgcca taatggatcc cttaccacta aggactaaaa atggcactag     1920

tggaaaagac tctgctacca catccactct aagcaaggac tctctcaatc ctagttccct     1980

cctggctgcc atgatgcaac aagatgagtc tatttatctc tatcctgctt caagtacttc     2040

aagtactgca ccttttgaaa acaacttttt caacgaatct atgaatgaat gcagaaattg     2100

gcaagataat actgcaccga tgggaaatga tactatcctg aaacatgagc aaattgacca     2160

gcctcaggat gtgaactcat ttgctggagg tcacccaggg ctctttcaag atagtaaaaa     2220

cagtgacttg tacagcataa tgaaaaacct aggcattgat tttgaagaca tcagacacat     2280

gcagaatgaa aaatttttca gaaatgattt ttctggtgag gttgacttca gagacattga     2340

cttaacggat gaaatcctga cgtatgtcca agattcttta agtaagtctc ccttcatacc     2400

ttcagattat caacagcaac agtccttggc tctgaactca agctgtatgg tacaggaaca     2460

cctacatcta gaacagcaac agcaacatca ccaaaagcaa gtagtagtgg agccacagca     2520

acagctgtgt cagaagatga agcacatgca agttaatggc atgtttgaaa attggaactc     2580

taaccaattc gtgcctttca attgtccaca gcaagaccca caacaatata atgtctttac     2640

agacttacat gggatcagtc aagagttccc ctacaaatct gaaatggatt ctatgcctta     2700

tacacagaac tttatttcct gtaatcagcc tgtattacca caacattcca aatgtacaga     2760

gctggactac cctatgggga gttttgaacc atccccatac cccactactt ctagtttaga     2820

agattttgtc acttgtttac aacttcctga aaaccaaaag catggattaa atccacagtc     2880

agccataata actcctcaga catgttatgc tggggccgtg tcgatgtatc agtgccagcc     2940

agaacctcag cacacccacg tgggtcagat gcagtacaat ccagtactgc caggccaaca     3000

ggcattttta aacaagtttc agaatggagt tttaaatgaa acatatccag ctgaattaaa     3060

taacataaat aacactcaga ctaccacaca tcttcagcca cttcatcatc cgtcagaagc     3120

cagacctttt cctgatttga catccagtgg attcctgtaa ttccaagccc aattttgacc     3180

ctggtttttg gattaaatta gtttgtgaag gattatggaa aaataaaact gtcactgttg     3240

gacgtcagca agttcacatg gaggcattga tgcatgctat tcacaattat tccaaaccaa     3300

attttaattt ttgcttttag aaaagggagt ttaaaaatgg tatcaaaatt acatatacta     3360

cagtcaagat agaaagggtg ctgccacgga gtggtgaggt accgtctaca tttcacatta     3420

ttctgggcac cacaaaatat acaaaacttt atcagggaaa ctaagattct tttaaattag     3480

aaaatattct ctatttgaat tatttctgtc acagtaaaaa taaaatactt tgagttttga     3540

gctactggat tcttattagt tccccaaata caaagttaga gaactaaact agtttttcct     3600

atcatgttaa cctctgcttt tatctcagat gttaaaataa atggtttggt gctttttata     3660

aaaagataat ctcagtgctt tcctccttca ctgtttcatc taagtgcctc acattttttt     3720

ctacctataa cactctagga tgtatatttt atataaagta ttctttttct tttttaaatt     3780

aatatctttc tgcacacaaa tattatttgt gtttcctaaa tccaaccatt ttcattaatt     3840

caggcatatt ttaactccac tgcttaccta ctttcttcag gtaaagggca aataatgatc     3900

gaaaaaataa ttatttatta cataatttag ttgtttctag actataaatg ttgctatgtg     3960

ccttatgttg aaaaaattta aaagtaaaat gtctttccaa attatttctt aattattata     4020

aaaatattaa gacaatagca cttaaattcc tcaacagtgt tttcagaaga aataaatata     4080

ccactcttta cctttattga tatctccatg atgatagttg aatgttgcaa tgtgaaaaat     4140

ctgctgttaa ctgcaacctt gtttattaaa ttgcaagaag ctttatttct agctttttaa     4200

ttaagcaaag cacccatttc aatgtgtata aattgtcttt aaaaactgtt ttagacctat     4260

aatccttgat aatatattgt gttgacttta taaatttcgc ttcttagaac agtggaaact     4320

atgtgttttt ctcatatttg aggagtgtta agattgcaga tagcaaggtt tggtgcaaag     4380

tattgtaatg agtgaattga atggtgcatt gtatagatat aatgaacaaa attatttgta     4440

agatatttgc agtttttcat tttaaaaagt ccatacctta tatatgcact taatttgttg     4500

gggctttaca tactttatca atgtgtcttt ctaagaaatc aagtaatgaa tccaactgct     4560

taaagttggt attaataaaa agacaaccac atagttcgtt taccttcaaa ctttaggttt     4620

ttttaatgat atactgatct tcattaccaa taggcaaatt aatcacccta ccaactttac     4680

tgtcctaaca tggtttaaaa gaaaaaatga caccatcttt tattcttttt tttttttttt     4740

tttgagagag agtcttactc tgccgcccaa actggagtgc agtggcacaa tcttggctca     4800

ctgcaacctc tacctcctgg gttcaagtga ttctcttgcc tcagcctccc gagttgctgg     4860

gattacaggc atgtgccacc atgcccagct aatttttgta tttttagtag aaacgggttt     4920

caccatgttg gccagactgg tctcaaactc ctgacctcag gtgagcctcc caccttggcc     4980

tcccaaagtg ctgggattac aggcgtgagc cactgcattc agctcttctt ttctttagat     5040

atgagagctg aagagcttag acacattttg catgtattat ttgaaaatct gatggaatcc     5100

caaactgaga tgtattaaaa tacaattttt ggccgggtgc agtggctcac gcctgtaatc     5160

ccagcacttg gggagggcga ggagggtgga tcacgaggtc aagagatgga gaccatcctg     5220

accaacatgg tgaaaccctg tctctactaa aaatacagaa attagctggg catggtggcg     5280

tgagcctgta gtcctagcta ctcaggaggc tgaggcagga gaatagcctg aacctgggaa     5340

tcggaggttg cagagccaag atcgccccac tgcactccag cctggcaata gaccgagact     5400

ccgtctccaa aaaaaaaaaa aatacaattt ttatttcttt tacttttttt agtaagttaa     5460

tgtatataaa aatggcttcg gacaaaatat ctctgagttc tgtgtatttt cagtcaaaac     5520

tttaaacctg tagaatcaat ttaagtgttg gaaaaaattt gtctgaaaca tttcataatt     5580

tgtttccagc atgaggtatc taaggattta gaccagaggt ctagattaat actctatttt     5640

tacatttaaa ccttttatta taagtcttac ataaaccatt tttgttactc tcttccacat     5700

gttactggat aaattgttta gtggaaaata ggctttttaa tcatgaatat gatgacaatc     5760

agttatacag ttataaaatt aaaagtttga aaagcaatat tgtatatttt tatctatata     5820

aaataactaa aatgtatcta agaataataa aatcacgtta aaccaaatac acgtttgtct     5880

gtattgttaa gtgccaaaca aaggatactt agtgcactgc tacattgtgg gatttatttc     5940

tagatgatgt gcacatctaa ggatatggat gtgtctaatt tagtcttttc ctgtaccagg     6000

tttttcttac aatacctgaa gacttaccag tattctagtg tattatgaag ctttcaacat     6060

tactatgcac aaactagtgt ttttcgatgt tactaaattt taggtaaatg ctttcatggc     6120

ttttttcttc aaaatgttac tgcttacata tatcatgcat agatttttgc ttaaagtatg     6180

atttataata tcctcattat caaagttgta tacaataata tataataaaa taacaaatat     6240

gaataat                                                               6247


<210>  4
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg 
    370                 375                 380                 


Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys 
            420                 425                 430         


Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu 
        835                 840                 845             


<210>  5
<211>  3962
<212>  DNA
<213>  Homo sapiens

<400>  5
agtcttccag cagggttctg aaagcagcct gctcccatcg cgcccctcgg atgtggacac       60

ccagggtggg ctgcagaccg cggccgggcc gcactctctg ggggcgaggg ccaggtcagg      120

tggctgcact gtcgcccagc agcgagtaaa gactcgaaac tgagggagcc agagccctag      180

tcactctgct ggtcgagggt cggaaccgct gggggaaaga ggaaatgtgg acgaaggcag      240

cccttcctgg agacagcttg gaagagaggg atgaagatgc aaaaagcaaa acccaaccta      300

tcaagtgcca cctccccggt gacaggcccc cagccttgct ctgcgctttc gctgaatgaa      360

ctcctgagca cgtttttccc gttgcctagg aagggttggg ccgcaggttt cgccagtgct      420

cgacaaccca cctggagata gcgggtcggg gagggagctg cgaggggggc ggactcctgt      480

tgctcagtct tcagaccgca gcacagcatc atctgcaccg ggacccggga atggggggac      540

acttggagac tgagagagag gaggctcgag gaatgaacct tggtctgttc taagccacaa      600

cccctgtctc aggtcgtttg gcttcctttc cttctctttg tatttgaatt taaaaacatt      660

cctgaatctc aagtgctttt gcttgaagta ggggggagga ggagaaaaga atagaagcaa      720

gccaggcttc ctaagcgagc tctgaaagga gaaatccatt cactgcaaac ctcgttcccc      780

atttctgaaa acggatagac tgatatcgta aactaaaggt catgagggtt tttccccccg      840

gtttggggga tttgttctgt taaaaggaat tttaaagcac cacttgagaa aataattttg      900

cctcagtttc cctaaactat ctttaaaatg ggttgccata attacaggtc ttcttttctc      960

tcacctctat aagccaccgt tttcaggtca tctgaagtca agatttccag ccttttgaat     1020

ggactgatgt gttctaagcc cgaagatcca gtagaatact tggaaagttg tttacaaaaa     1080

gtaaaggaac tgggtggctg tgacaaggtg aaatgggata catttgtaag ccaggaaaag     1140

aagaccttac ctccactaaa tggaggacag tcacggagat cctttctaag aaatgtaatg     1200

cctgaaaact caaactttcc atatcggcgg tatgaccggc tccctccaat ccatcaattc     1260

tccatagaaa gtgacacgga tctctctgag actgcagagt tgattgagga gtatgaggtt     1320

tttgatccta ccagacctcg accaaaaatc attcttgtta taggtggtcc aggaagtgga     1380

aagggtactc agagtttgaa aattgcagaa cgatatggat tccaatacat ttctgtggga     1440

gaattattaa gaaagaagat ccacagtacc agcagcaata ggaaatggag tcttattgcc     1500

aagataatta caactggaga attggcccca caggaaacaa caattacaga gataaaacaa     1560

aaattgatgc aaatacctga tgaagagggc attgttattg atggatttcc aagagatgtt     1620

gcccaggctc tatcttttga ggaccaaatc tgtacccccg atttggtggt attcctggct     1680

tgtgctaatc agagactcaa agaaagatta ctgaagcgtg cagaacagca gggccgacca     1740

gacgacaatg taaaagctac ccaaaggaga ctaatgaact tcaagcagaa tgctgctcca     1800

ttggttaaat acttccagga aaaggggctc atcatgacat ttgatgccga ccgcgatgag     1860

gatgaggtgt tctatgacat cagcatggca gttgacaaca agttatttcc aaacaaagag     1920

gctgcagcag gttcaagtga ccttgatcct tcgatgatat tggacactgg agagatcatt     1980

gatacaggat ctgattatga agatcagggt gatgaccagt taaatgtatt tggagaggac     2040

actatgggag gtttcatgga agatttgaga aagtgtaaaa ttattttcat aattggtggt     2100

cctggctctg gcaaaggcac acagtgtgaa aagctggtgg aaaaatatgg atttacacat     2160

ctctcaactg gcgagctcct gcgtgaggaa ctggcatcag aatctgaaag aagcaaattg     2220

atcagagaca ttatggaacg tggagacctg gtgccctcag gcatcgtttt ggagctcctg     2280

aaggaggcca tggtggccag cctcggggac accaggggct tcctgattga cggctatcct     2340

cgggaggtga agcaagggga agagttcgga cgcaggattg gagacccaca gttggtgatc     2400

tgtatggact gctcggcaga caccatgacc aaccgccttc tccaaaggag ccggagcagc     2460

ctgcctgtgg acgacaccac caagaccatc gccaagcgcc tagaagccta ctaccgagcg     2520

tccatccccg tgatcgccta ctacgagaca aaaacacagc tacacaagat aaatgcagag     2580

ggaacaccag aggacgtttt tcttcaactc tgcacagcta ttgactctat tttctgaagg     2640

caaaaatgca tgtttgttag aatggaaaca gaaaaacatt aaaaagttca ttccttaaca     2700

caatgtttca agttaaacct tttgtgtcac cgcccccacc aaccaccacc tcctaaatcc     2760

tgacagcact gtttgcttcc cagctagacc tgtgtgagag gtgtctggaa atcatgcatg     2820

gtgtatttgg gactatatca acctattctc cacacttcag acaactgtct gcactcacgg     2880

cacacacact ttgtatcatg caggccacac tcagagctag tcagtacatg aacagtggtg     2940

cggtgccagt ctgtgtccgt tgtgatcaca ggccttgcta gaccctgatc atctggttct     3000

cctctcatta agcatcccta acccccagtc acaccttcct cttacatact gttccccaat     3060

ggaggcccct ggcatagggg acagccctgg gcatcttcct ttggtgtctg gctgttttgt     3120

caactctcat ccactggtgg ctcagagcca taaggtgggt tgattacaca atgccttgta     3180

catgatatag aggcatcaag caagtaaaat ttgacagaaa ttttaaaata tgaagatgta     3240

tagctttccc aagatgatgg taaaacccag gttagtcatc agtaaccttc tctattatta     3300

ttatttttta gaaacttgga atactgtcgt catggctaag agaacaaatc tgataaattg     3360

tgtaacctag tctcttctct acatggtgat gcatttcagc aattataaat taatataaat     3420

gaccaaaagt aacttaaaag catgagatat ttgctatttc attcattggg cacatatcaa     3480

attataattt tgattttaaa tggtcaccca tgtatttatt tgttgccaag caagtaaaaa     3540

aataccctaa caaacctgat gtgggtggga ggggcatgtc agtaagtggt gtgttcaatg     3600

tgtttgtttc atatgggccc tttccaggag tttgcaaacc ttgtcatacc catatgcaaa     3660

actgtgtttc cttgcattaa accagtgaag tttgggttct cttttgtgct atcaatcagt     3720

tgtaaaatca gagctgctta tatattctac tggaataact gcatcttcca ctcagtcact     3780

acaaaaaagc atagtttcag tttgcatgaa tttttttttt tttcttcaat ggctgtgcag     3840

ataaggatcc atttctggga tagaattgta ttttttaagt catttttttt tcttgaaatg     3900

gatatgtaca aataaaataa atggaagaca ggataaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aa                                                                    3962


<210>  6
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Ser Lys Pro Glu Asp Pro Val Glu Tyr Leu Glu Ser Cys Leu 
1               5                   10                  15      


Gln Lys Val Lys Glu Leu Gly Gly Cys Asp Lys Val Lys Trp Asp Thr 
            20                  25                  30          


Phe Val Ser Gln Glu Lys Lys Thr Leu Pro Pro Leu Asn Gly Gly Gln 
        35                  40                  45              


Ser Arg Arg Ser Phe Leu Arg Asn Val Met Pro Glu Asn Ser Asn Phe 
    50                  55                  60                  


Pro Tyr Arg Arg Tyr Asp Arg Leu Pro Pro Ile His Gln Phe Ser Ile 
65                  70                  75                  80  


Glu Ser Asp Thr Asp Leu Ser Glu Thr Ala Glu Leu Ile Glu Glu Tyr 
                85                  90                  95      


Glu Val Phe Asp Pro Thr Arg Pro Arg Pro Lys Ile Ile Leu Val Ile 
            100                 105                 110         


Gly Gly Pro Gly Ser Gly Lys Gly Thr Gln Ser Leu Lys Ile Ala Glu 
        115                 120                 125             


Arg Tyr Gly Phe Gln Tyr Ile Ser Val Gly Glu Leu Leu Arg Lys Lys 
    130                 135                 140                 


Ile His Ser Thr Ser Ser Asn Arg Lys Trp Ser Leu Ile Ala Lys Ile 
145                 150                 155                 160 


Ile Thr Thr Gly Glu Leu Ala Pro Gln Glu Thr Thr Ile Thr Glu Ile 
                165                 170                 175     


Lys Gln Lys Leu Met Gln Ile Pro Asp Glu Glu Gly Ile Val Ile Asp 
            180                 185                 190         


Gly Phe Pro Arg Asp Val Ala Gln Ala Leu Ser Phe Glu Asp Gln Ile 
        195                 200                 205             


Cys Thr Pro Asp Leu Val Val Phe Leu Ala Cys Ala Asn Gln Arg Leu 
    210                 215                 220                 


Lys Glu Arg Leu Leu Lys Arg Ala Glu Gln Gln Gly Arg Pro Asp Asp 
225                 230                 235                 240 


Asn Val Lys Ala Thr Gln Arg Arg Leu Met Asn Phe Lys Gln Asn Ala 
                245                 250                 255     


Ala Pro Leu Val Lys Tyr Phe Gln Glu Lys Gly Leu Ile Met Thr Phe 
            260                 265                 270         


Asp Ala Asp Arg Asp Glu Asp Glu Val Phe Tyr Asp Ile Ser Met Ala 
        275                 280                 285             


Val Asp Asn Lys Leu Phe Pro Asn Lys Glu Ala Ala Ala Gly Ser Ser 
    290                 295                 300                 


Asp Leu Asp Pro Ser Met Ile Leu Asp Thr Gly Glu Ile Ile Asp Thr 
305                 310                 315                 320 


Gly Ser Asp Tyr Glu Asp Gln Gly Asp Asp Gln Leu Asn Val Phe Gly 
                325                 330                 335     


Glu Asp Thr Met Gly Gly Phe Met Glu Asp Leu Arg Lys Cys Lys Ile 
            340                 345                 350         


Ile Phe Ile Ile Gly Gly Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu 
        355                 360                 365             


Lys Leu Val Glu Lys Tyr Gly Phe Thr His Leu Ser Thr Gly Glu Leu 
    370                 375                 380                 


Leu Arg Glu Glu Leu Ala Ser Glu Ser Glu Arg Ser Lys Leu Ile Arg 
385                 390                 395                 400 


Asp Ile Met Glu Arg Gly Asp Leu Val Pro Ser Gly Ile Val Leu Glu 
                405                 410                 415     


Leu Leu Lys Glu Ala Met Val Ala Ser Leu Gly Asp Thr Arg Gly Phe 
            420                 425                 430         


Leu Ile Asp Gly Tyr Pro Arg Glu Val Lys Gln Gly Glu Glu Phe Gly 
        435                 440                 445             


Arg Arg Ile Gly Asp Pro Gln Leu Val Ile Cys Met Asp Cys Ser Ala 
    450                 455                 460                 


Asp Thr Met Thr Asn Arg Leu Leu Gln Arg Ser Arg Ser Ser Leu Pro 
465                 470                 475                 480 


Val Asp Asp Thr Thr Lys Thr Ile Ala Lys Arg Leu Glu Ala Tyr Tyr 
                485                 490                 495     


Arg Ala Ser Ile Pro Val Ile Ala Tyr Tyr Glu Thr Lys Thr Gln Leu 
            500                 505                 510         


His Lys Ile Asn Ala Glu Gly Thr Pro Glu Asp Val Phe Leu Gln Leu 
        515                 520                 525             


Cys Thr Ala Ile Asp Ser Ile Phe 
    530                 535     


<210>  7
<211>  3257
<212>  DNA
<213>  Homo sapiens

<400>  7
cagctgctcg gcgcctgcag ctccggctcg ggggctggaa ccgaagcggg ggcggcggga       60

gcgcggagac cacagccccc ggggagaggc ggagggggtc cctggcctgg gcggagaggc      120

tgagctgagt gcgcgtgaga aagagggctg caccgctgct cggcgcggac tctgccagcc      180

ccagcttcag ccccggctca ggtcgccgca gcccgggagc ctccccgctt gcgccccaag      240

gcacgcgcgg cacagccatg aacaccaacg atgccaagga gtatctggcc cggagggaaa      300

tccctcagct ttttgagagc cttttgaatg gactgatgtg ttctaagccc gaagatccag      360

tagaatactt ggaaagttgt ttacaaaaag taaaggaact gggtggctgt gacaaggtga      420

aatgggatac atttgtaagc caggaaaaga agaccttacc tccactaaat ggaggacagt      480

cacggagatc ctttctaaga aatgtaatgc ctgaaaactc aaactttcca tatcggcggt      540

atgaccggct ccctccaatc catcaattct ccatagaaag tgacacggat ctctctgaga      600

ctgcagagtt gattgaggag tatgaggttt ttgatcctac cagacctcga ccaaaaatca      660

ttcttgttat aggtggtcca ggaagtggaa agggtactca gagtttgaaa attgcagaac      720

gatatggatt ccaatacatt tctgtgggag aattattaag aaagaagatc cacagtacca      780

gcagcaatag gaaatggagt cttattgcca agataattac aactggagaa ttggccccac      840

aggaaacaac aattacagag ataaaacaaa aattgatgca aatacctgat gaagagggca      900

ttgttattga tggatttcca agagatgttg cccaggctct atcttttgag gaccaaatct      960

gtacccccga tttggtggta ttcctggctt gtgctaatca gagactcaaa gaaagattac     1020

tgaagcgtgc agaacagcag ggccgaccag acgacaatgt aaaagctacc caaaggagac     1080

taatgaactt caagcagaat gctgctccat tggttaaata cttccaggaa aaggggctca     1140

tcatgacatt tgatgccgac cgcgatgagg atgaggtgtt ctatgacatc agcatggcag     1200

ttgacaacaa gttatttcca aacaaagagg ctgcagcagg ttcaagtgac cttgatcctt     1260

cgatgatatt ggacactgga gagatcattg atacaggatc tgattatgaa gatcagggtg     1320

atgaccagtt aaatgtattt ggagaggaca ctatgggagg tttcatggaa gatttgagaa     1380

agtgtaaaat tattttcata attggtggtc ctggctctgg caaaggcaca cagtgtgaaa     1440

agctggtgga aaaatatgga tttacacatc tctcaactgg cgagctcctg cgtgaggaac     1500

tggcatcaga atctgaaaga agcaaattga tcagagacat tatggaacgt ggagacctgg     1560

tgccctcagg catcgttttg gagctcctga aggaggccat ggtggccagc ctcggggaca     1620

ccaggggctt cctgattgac ggctatcctc gggaggtgaa gcaaggggaa gagttcggac     1680

gcaggattgg agacccacag ttggtgatct gtatggactg ctcggcagac accatgacca     1740

accgccttct ccaaaggagc cggagcagcc tgcctgtgga cgacaccacc aagaccatcg     1800

ccaagcgcct agaagcctac taccgagcgt ccatccccgt gatcgcctac tacgagacaa     1860

aaacacagct acacaagata aatgcagagg gaacaccaga ggacgttttt cttcaactct     1920

gcacagctat tgactctatt ttctgaaggc aaaaatgcat gtttgttaga atggaaacag     1980

aaaaacatta aaaagttcat tccttaacac aatgtttcaa gttaaacctt ttgtgtcacc     2040

gcccccacca accaccacct cctaaatcct gacagcactg tttgcttccc agctagacct     2100

gtgtgagagg tgtctggaaa tcatgcatgg tgtatttggg actatatcaa cctattctcc     2160

acacttcaga caactgtctg cactcacggc acacacactt tgtatcatgc aggccacact     2220

cagagctagt cagtacatga acagtggtgc ggtgccagtc tgtgtccgtt gtgatcacag     2280

gccttgctag accctgatca tctggttctc ctctcattaa gcatccctaa cccccagtca     2340

caccttcctc ttacatactg ttccccaatg gaggcccctg gcatagggga cagccctggg     2400

catcttcctt tggtgtctgg ctgttttgtc aactctcatc cactggtggc tcagagccat     2460

aaggtgggtt gattacacaa tgccttgtac atgatataga ggcatcaagc aagtaaaatt     2520

tgacagaaat tttaaaatat gaagatgtat agctttccca agatgatggt aaaacccagg     2580

ttagtcatca gtaaccttct ctattattat tattttttag aaacttggaa tactgtcgtc     2640

atggctaaga gaacaaatct gataaattgt gtaacctagt ctcttctcta catggtgatg     2700

catttcagca attataaatt aatataaatg accaaaagta acttaaaagc atgagatatt     2760

tgctatttca ttcattgggc acatatcaaa ttataatttt gattttaaat ggtcacccat     2820

gtatttattt gttgccaagc aagtaaaaaa ataccctaac aaacctgatg tgggtgggag     2880

gggcatgtca gtaagtggtg tgttcaatgt gtttgtttca tatgggccct ttccaggagt     2940

ttgcaaacct tgtcataccc atatgcaaaa ctgtgtttcc ttgcattaaa ccagtgaagt     3000

ttgggttctc ttttgtgcta tcaatcagtt gtaaaatcag agctgcttat atattctact     3060

ggaataactg catcttccac tcagtcacta caaaaaagca tagtttcagt ttgcatgaat     3120

tttttttttt ttcttcaatg gctgtgcaga taaggatcca tttctgggat agaattgtat     3180

tttttaagtc attttttttt cttgaaatgg atatgtacaa ataaaataaa tggaagacag     3240

gataaaaaaa aaaaaaa                                                    3257


<210>  8
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asn Thr Asn Asp Ala Lys Glu Tyr Leu Ala Arg Arg Glu Ile Pro 
1               5                   10                  15      


Gln Leu Phe Glu Ser Leu Leu Asn Gly Leu Met Cys Ser Lys Pro Glu 
            20                  25                  30          


Asp Pro Val Glu Tyr Leu Glu Ser Cys Leu Gln Lys Val Lys Glu Leu 
        35                  40                  45              


Gly Gly Cys Asp Lys Val Lys Trp Asp Thr Phe Val Ser Gln Glu Lys 
    50                  55                  60                  


Lys Thr Leu Pro Pro Leu Asn Gly Gly Gln Ser Arg Arg Ser Phe Leu 
65                  70                  75                  80  


Arg Asn Val Met Pro Glu Asn Ser Asn Phe Pro Tyr Arg Arg Tyr Asp 
                85                  90                  95      


Arg Leu Pro Pro Ile His Gln Phe Ser Ile Glu Ser Asp Thr Asp Leu 
            100                 105                 110         


Ser Glu Thr Ala Glu Leu Ile Glu Glu Tyr Glu Val Phe Asp Pro Thr 
        115                 120                 125             


Arg Pro Arg Pro Lys Ile Ile Leu Val Ile Gly Gly Pro Gly Ser Gly 
    130                 135                 140                 


Lys Gly Thr Gln Ser Leu Lys Ile Ala Glu Arg Tyr Gly Phe Gln Tyr 
145                 150                 155                 160 


Ile Ser Val Gly Glu Leu Leu Arg Lys Lys Ile His Ser Thr Ser Ser 
                165                 170                 175     


Asn Arg Lys Trp Ser Leu Ile Ala Lys Ile Ile Thr Thr Gly Glu Leu 
            180                 185                 190         


Ala Pro Gln Glu Thr Thr Ile Thr Glu Ile Lys Gln Lys Leu Met Gln 
        195                 200                 205             


Ile Pro Asp Glu Glu Gly Ile Val Ile Asp Gly Phe Pro Arg Asp Val 
    210                 215                 220                 


Ala Gln Ala Leu Ser Phe Glu Asp Gln Ile Cys Thr Pro Asp Leu Val 
225                 230                 235                 240 


Val Phe Leu Ala Cys Ala Asn Gln Arg Leu Lys Glu Arg Leu Leu Lys 
                245                 250                 255     


Arg Ala Glu Gln Gln Gly Arg Pro Asp Asp Asn Val Lys Ala Thr Gln 
            260                 265                 270         


Arg Arg Leu Met Asn Phe Lys Gln Asn Ala Ala Pro Leu Val Lys Tyr 
        275                 280                 285             


Phe Gln Glu Lys Gly Leu Ile Met Thr Phe Asp Ala Asp Arg Asp Glu 
    290                 295                 300                 


Asp Glu Val Phe Tyr Asp Ile Ser Met Ala Val Asp Asn Lys Leu Phe 
305                 310                 315                 320 


Pro Asn Lys Glu Ala Ala Ala Gly Ser Ser Asp Leu Asp Pro Ser Met 
                325                 330                 335     


Ile Leu Asp Thr Gly Glu Ile Ile Asp Thr Gly Ser Asp Tyr Glu Asp 
            340                 345                 350         


Gln Gly Asp Asp Gln Leu Asn Val Phe Gly Glu Asp Thr Met Gly Gly 
        355                 360                 365             


Phe Met Glu Asp Leu Arg Lys Cys Lys Ile Ile Phe Ile Ile Gly Gly 
    370                 375                 380                 


Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Leu Val Glu Lys Tyr 
385                 390                 395                 400 


Gly Phe Thr His Leu Ser Thr Gly Glu Leu Leu Arg Glu Glu Leu Ala 
                405                 410                 415     


Ser Glu Ser Glu Arg Ser Lys Leu Ile Arg Asp Ile Met Glu Arg Gly 
            420                 425                 430         


Asp Leu Val Pro Ser Gly Ile Val Leu Glu Leu Leu Lys Glu Ala Met 
        435                 440                 445             


Val Ala Ser Leu Gly Asp Thr Arg Gly Phe Leu Ile Asp Gly Tyr Pro 
    450                 455                 460                 


Arg Glu Val Lys Gln Gly Glu Glu Phe Gly Arg Arg Ile Gly Asp Pro 
465                 470                 475                 480 


Gln Leu Val Ile Cys Met Asp Cys Ser Ala Asp Thr Met Thr Asn Arg 
                485                 490                 495     


Leu Leu Gln Arg Ser Arg Ser Ser Leu Pro Val Asp Asp Thr Thr Lys 
            500                 505                 510         


Thr Ile Ala Lys Arg Leu Glu Ala Tyr Tyr Arg Ala Ser Ile Pro Val 
        515                 520                 525             


Ile Ala Tyr Tyr Glu Thr Lys Thr Gln Leu His Lys Ile Asn Ala Glu 
    530                 535                 540                 


Gly Thr Pro Glu Asp Val Phe Leu Gln Leu Cys Thr Ala Ile Asp Ser 
545                 550                 555                 560 


Ile Phe 
        


<210>  9
<211>  4984
<212>  DNA
<213>  Homo sapiens

<400>  9
ggttatttgt ggttcgcttt gatcccgagg gggaacctga aactctcaca ttcctggcat       60

agcagccgcc tccggcgcgg gccgaccctg gggctgcgcg ctggggcgcg aacagccaga      120

gcgtcggcgc cacggccgag aacacatctt cgccgccgag ctgagctggg ccgagccgga      180

ggttgtggtg tctgactgcg ctgggcaccc tcgggccgca gcggtgctct ggggccaggt      240

gccaccggcc attgtccagg cagctgtgtg caagccaaag aagcatgagg acactggaag      300

actcctcggg gacagtcctg caccgcctca tccaggagca gctgcgctac ggcaacctga      360

ctgagacgcg cacgctgcta gccatccagc agcaggccct gaggggtggg gctggaactg      420

ggggtacagg gagcccccag gcctccctgg agatcctggc cccagaggac agtcaggtgc      480

tgcagcaggc caccaggcag gagccccagg gccaggagca ccagggcggt gagaaccacc      540

tggcagagaa caccctctac cggctatgcc cacagcccag caagggagag gagctgccca      600

cctatgagga ggccaaagcc cactcgcagt actatgcggc ccagcaggca gggacccggc      660

cacatgcggg ggaccgagat ccccgtgggg ccccgggagg cagtcggagg caggacgagg      720

ccctgcggga gctgaggcat gggcacgtgc gctcgttgag tgaacggctc cttcagttgt      780

ccctggagag gaacggcgcc cgggccccca gccacatgag ctcctcccac agcttcccac      840

agctggcccg caaccagcag ggccccccac tgaggggccc ccctgctgag ggcccagagt      900

cccgaggacc cccacctcag taccctcatg ttgtactagc tcatgagacc accactgctg      960

tcactgaccc acggtaccgt gcccgcggca gcccgcactt ccagcatgct gaagtcagga     1020

tcctgcaggc ccaggtgcct cctgtgttcc tccaacagca gcagcagtac cagtacctgc     1080

agcaatctca ggagcacccc cctcccccac atccagctgc tctcggccat ggccccctga     1140

gctccctcag tccacctgct gtggaggggc cagtgagtgc ccaggcctcc tcagccacct     1200

cgggcagtgc ccacctggcc cagatggagg ccgtgctgag ggagaatgcc aggctgcaga     1260

gagacaatga gcggctgcag agggagctgg agagctctgc ggagaaggct ggccgcattg     1320

agaagctgga aagcgaaatc cagcggctct ctgaggccca tgagagcctg accagagcct     1380

cctccaagcg tgaggccctg gagaagacca tgcggaacaa gatggacagt gaaatgagga     1440

ggctgcaaga cttcaaccgg gatcttagag agagattgga atctgcaaat cgccgcctgg     1500

caagcaagac acaggaggcc caggccggca gtcaggacat ggtggccaag ctgcttgctc     1560

agagctacga acagcagcag gagcaagaga agctggagcg agagatggca ctgctgcgcg     1620

gcgccatcga ggaccagcgg cggcgtgccg agctgctgga gcaggctctg ggcaatgcgc     1680

agggccgggc agctcgagcc gaagaggagc tgcgcaagaa gcaggcctat gtggagaaag     1740

tggagcggct gcagcaggcg ctcgggcagc tgcaggcagc ctgtgagaag cgggagcagc     1800

tggagctgcg tctgcggact cgcctggagc aggaactcaa ggccctgcgt gcacagcaga     1860

gacaggcagg tgccccaggt ggtagcagtg gcagtggtgg gtctccagag ctcagcgccc     1920

tgcgactgtc agaacaactg cgagagaagg aggagcagat cctggcgctg gaggccgaca     1980

tgaccaagtg ggagcagaag tatttggagg aacgtgccat gaggcagttt gccatggatg     2040

cggctgccac ggctgctgct cagcgtgaca ccactctcat ccgacattcc ccccagccct     2100

cacccagcag cagcttcaat gagggtctgc tcactggtgg ccacaggcat caggagatgg     2160

aaagcaggtt aaaggtgctc catgcccaga tcctggagaa ggatgcagtg atcaaggtcc     2220

ttcagcagcg ctccaggaga gaccctggca aggccatcca gggctccctg cggcctgcca     2280

agtcggtgcc atctgttttc gcggctgcgg cagcaggaac ccagggctgg caagggctct     2340

cttctagtga gcgacaaaca gcagacgccc ctgctcggct gactacagca gacagagcac     2400

ccacagagga gccagtggtc acagctcccc ctgctgccca tgccaaacac gggagcagag     2460

atgggagcac ccagactgag ggccccccag acagcacctc cacctgcctg ccaccggagc     2520

ctgacagcct tctggggtgc agcagtagcc agagagcagc ctctctggac tctgtagcta     2580

catccagagt ccaggacttg tcagacatgg tggagatact gatctgaagg aggtggtgct     2640

tcaggactct gagccattct ctcccctcct ctgccctgtg ccactctcag ccatttcagc     2700

agccccgtca accgctgctc cgtccctttc cccagccaga cactcattcc cattgaccat     2760

ctggtcccag gagctcagga ggaggacccc aggggagagg agagctgtga gagcaccggc     2820

acccccagaa gactctgctt cttagcccac attcctccgg gccttatgga gaatgaggat     2880

tcagccttga cttcttgccc aaggcctgct actggggtag caactgacag ctcagaaagg     2940

agctgagctc cctctgccct gccagttgtc agtcaggcag ggagggagtg gctgtgttgg     3000

tttggggaac taatttccac ggacggctgc ccgtggacac caggtggact ggttcactaa     3060

tcaagtcagc catattgttc tctggctaag tttggttcca gccaacgtca tctgctcttc     3120

agttcctcac tgccttcttg ggatactaag acttgaattt tttggggact attaagggtg     3180

ttagtcttgg agaagacaca gcctcacctt ctcacttgct gtgggtgagg ggccatttaa     3240

gtggactggg agacagtgcg cagtttgtat ataattccct ttcttgtgga acagaagact     3300

gaggcctgca ggttccgatg tgtctccatg ggctgtgctc ccctcttcct actgtcagtt     3360

tctgaaactt ctgactggcc tcccagttat gcctcctcct caagttcctg gcccgtggat     3420

gttaaagctg ctcgattccc aggatctcgg ctgccttttc ctctatcttg agccctataa     3480

atgcccacgg gacccccacc accagcctct tgaagtggct ccacagctcc tgtccctgga     3540

acatcctgtc agtttggtca taaaccctga gccagatgaa atgagccacc gtgaacagac     3600

atctgccatg cccccaggtg ggcttcggtg gccctacccg gtaccagttc tttctgagaa     3660

actggagatg tcttgttagc ataagtgtct tcattcccac ctggagggtt tgggagagga     3720

gcaaagcagt tgaaaactag ttaatgagct acaagagtca aatagtcctc tgaatggagc     3780

ccccatcaca aaacagtgcc caggaggctg gctcctcaag ctacccatgc ccagcgccct     3840

aaagcagcac cagatgcttt ggaattgggg tgaaacaccc acatggcagc ctgctagcag     3900

cagtgacttt gacttctggt cttaaagagt ccctcacttc agccccagga gctattggtg     3960

ggttttagca gttttgtctt taccgttttt agttctcctt gattctttgt tttcttcctt     4020

tatcgttttt aggtttggta tgtgttgttt tatttccatg gttcctcaag tttccttttt     4080

aaacatttgc atttgctgga caattgcaat tttttttaaa aaattcccct acccctgttt     4140

aaagctgaaa aatacatttg gttcatgtgc attgtttaca aagcaaaaag aaaaaagagg     4200

aaaaaaaggc aaaaaatatt gtgaaagaaa aaaaacaact taatatattt tggattaata     4260

tttggtattt cttttaaagt attttttgtg ctgtgaacat tttctgccaa agaccatgat     4320

gtgtgtctgt atgtttaagt tatcgtaaat atttaaaatg taaacatggc tgttttgtta     4380

tgccaccctg taccaggatt gctgccgcat tccactgggt ataacagtat tttaattaaa     4440

aaaaaataat taaaagtgat gtctttgcac aggtgagact ttgcactgag ggaagggaaa     4500

gggtgaggat tttggggggc cacccaagtc atagtccaat ctcttcaagg acccaagata     4560

gaatttagga attttgtgaa gctgcattaa ggatagagtt ggaatgagga tgtggctggc     4620

atttttcccc tttcatagat aacatttctt gaaggctggg aggggaagga gggcctggca     4680

gatggcagcc tcccgaggta gggctgtgtt ctaatcagct ttgttcggcc acacgctgtg     4740

gttatccaca gtgggagtgg gtgtccaaag atggctttat ccttccccca ctccttttcc     4800

cactcccacc tagcacataa agttttgtcc gaaaccatcc agaaggccag gcaccatgca     4860

gaggacattc aagaatgtgc atgttcttag ccaccgcctc cctcctttgc tgtgacatca     4920

ccactctttc ctgatgctca ggaaagcata ttgctccaat tcaaaattaa agaaagccat     4980

tctc                                                                  4984


<210>  10
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Thr Leu Glu Asp Ser Ser Gly Thr Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Thr Glu Thr Arg Thr Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Thr Gly Gly Thr 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Thr Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Thr Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Thr Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Thr Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg His Gly His Val Arg Ser Leu Ser Glu 
145                 150                 155                 160 


Arg Leu Leu Gln Leu Ser Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser 
                165                 170                 175     


His Met Ser Ser Ser His Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln 
            180                 185                 190         


Gly Pro Pro Leu Arg Gly Pro Pro Ala Glu Gly Pro Glu Ser Arg Gly 
        195                 200                 205             


Pro Pro Pro Gln Tyr Pro His Val Val Leu Ala His Glu Thr Thr Thr 
    210                 215                 220                 


Ala Val Thr Asp Pro Arg Tyr Arg Ala Arg Gly Ser Pro His Phe Gln 
225                 230                 235                 240 


His Ala Glu Val Arg Ile Leu Gln Ala Gln Val Pro Pro Val Phe Leu 
                245                 250                 255     


Gln Gln Gln Gln Gln Tyr Gln Tyr Leu Gln Gln Ser Gln Glu His Pro 
            260                 265                 270         


Pro Pro Pro His Pro Ala Ala Leu Gly His Gly Pro Leu Ser Ser Leu 
        275                 280                 285             


Ser Pro Pro Ala Val Glu Gly Pro Val Ser Ala Gln Ala Ser Ser Ala 
    290                 295                 300                 


Thr Ser Gly Ser Ala His Leu Ala Gln Met Glu Ala Val Leu Arg Glu 
305                 310                 315                 320 


Asn Ala Arg Leu Gln Arg Asp Asn Glu Arg Leu Gln Arg Glu Leu Glu 
                325                 330                 335     


Ser Ser Ala Glu Lys Ala Gly Arg Ile Glu Lys Leu Glu Ser Glu Ile 
            340                 345                 350         


Gln Arg Leu Ser Glu Ala His Glu Ser Leu Thr Arg Ala Ser Ser Lys 
        355                 360                 365             


Arg Glu Ala Leu Glu Lys Thr Met Arg Asn Lys Met Asp Ser Glu Met 
    370                 375                 380                 


Arg Arg Leu Gln Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Ser 
385                 390                 395                 400 


Ala Asn Arg Arg Leu Ala Ser Lys Thr Gln Glu Ala Gln Ala Gly Ser 
                405                 410                 415     


Gln Asp Met Val Ala Lys Leu Leu Ala Gln Ser Tyr Glu Gln Gln Gln 
            420                 425                 430         


Glu Gln Glu Lys Leu Glu Arg Glu Met Ala Leu Leu Arg Gly Ala Ile 
        435                 440                 445             


Glu Asp Gln Arg Arg Arg Ala Glu Leu Leu Glu Gln Ala Leu Gly Asn 
    450                 455                 460                 


Ala Gln Gly Arg Ala Ala Arg Ala Glu Glu Glu Leu Arg Lys Lys Gln 
465                 470                 475                 480 


Ala Tyr Val Glu Lys Val Glu Arg Leu Gln Gln Ala Leu Gly Gln Leu 
                485                 490                 495     


Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu Leu Arg Leu Arg Thr 
            500                 505                 510         


Arg Leu Glu Gln Glu Leu Lys Ala Leu Arg Ala Gln Gln Arg Gln Ala 
        515                 520                 525             


Gly Ala Pro Gly Gly Ser Ser Gly Ser Gly Gly Ser Pro Glu Leu Ser 
    530                 535                 540                 


Ala Leu Arg Leu Ser Glu Gln Leu Arg Glu Lys Glu Glu Gln Ile Leu 
545                 550                 555                 560 


Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu Glu Glu 
                565                 570                 575     


Arg Ala Met Arg Gln Phe Ala Met Asp Ala Ala Ala Thr Ala Ala Ala 
            580                 585                 590         


Gln Arg Asp Thr Thr Leu Ile Arg His Ser Pro Gln Pro Ser Pro Ser 
        595                 600                 605             


Ser Ser Phe Asn Glu Gly Leu Leu Thr Gly Gly His Arg His Gln Glu 
    610                 615                 620                 


Met Glu Ser Arg Leu Lys Val Leu His Ala Gln Ile Leu Glu Lys Asp 
625                 630                 635                 640 


Ala Val Ile Lys Val Leu Gln Gln Arg Ser Arg Arg Asp Pro Gly Lys 
                645                 650                 655     


Ala Ile Gln Gly Ser Leu Arg Pro Ala Lys Ser Val Pro Ser Val Phe 
            660                 665                 670         


Ala Ala Ala Ala Ala Gly Thr Gln Gly Trp Gln Gly Leu Ser Ser Ser 
        675                 680                 685             


Glu Arg Gln Thr Ala Asp Ala Pro Ala Arg Leu Thr Thr Ala Asp Arg 
    690                 695                 700                 


Ala Pro Thr Glu Glu Pro Val Val Thr Ala Pro Pro Ala Ala His Ala 
705                 710                 715                 720 


Lys His Gly Ser Arg Asp Gly Ser Thr Gln Thr Glu Gly Pro Pro Asp 
                725                 730                 735     


Ser Thr Ser Thr Cys Leu Pro Pro Glu Pro Asp Ser Leu Leu Gly Cys 
            740                 745                 750         


Ser Ser Ser Gln Arg Ala Ala Ser Leu Asp Ser Val Ala Thr Ser Arg 
        755                 760                 765             


Val Gln Asp Leu Ser Asp Met Val Glu Ile Leu Ile 
    770                 775                 780 


<210>  11
<211>  2567
<212>  DNA
<213>  Homo sapiens

<400>  11
caatgacagg cggcaggcgg tgaccgccgc agggcctgcg gagaccgtcc gcctggctcg       60

cccgagctcg cccgctgtcc gccagcccgc gggagggagg agagaagcga agcgtttccg      120

cggttggcta ctcagtgtct tggtctcaag ttgcctcatt gcggctggcg ttcccaatac      180

agacgcatcg tttctttttt aatactccct aagaaaggga ataaccttca agctggcggg      240

agcaatggtt cacataaaga aaggcgagct gacccaggag gagaaggagc tactggaagt      300

catcgggaaa ggtactgtcc aagaagctgg aacattatta tccagcaaga atgttcgtgt      360

caactgtttg gacgagaatg gaatgactcc tctaatgcat gcagcatata aaggaaaact      420

cgatatgtgc aaattactac tgcgacatgg agccgatgta aattgtcatc agcatgaaca      480

tggatacaca gccctcatgt ttgctgcact ttctggtaat aaagacatca catgggtaat      540

gttagaagct ggtgctgaga cagatgttgt caactctgtg ggaagaacag cagctcagat      600

ggcagccttt gtgggtcaac atgattgtgt gaccataatc aacaatttct ttcctcgaga      660

gagactggat tattacacta agccccaggg actggataaa gagccaaaac tgcccccaaa      720

gttggcaggc ccgctgcaca aaattatcac cacaacgaat cttcatcctg tcaagatcgt      780

gatgcttgta aatgagaatc ctctgctgac agaagaagca gccctgaata aatgctacag      840

agtgatggat ttgatttgtg agaaatgtat gaagcaaaga gacatgaatg aagtattggc      900

tatgaagatg cattacataa gctgtatctt tcagaaatgc attaacttct taaaagatgg      960

agagaataaa ctggacacct tgatcaaaag cttgttaaaa ggccgagctt ctgatggctt     1020

tccagtgtat caagaaaaga tcattagaga aagtatcaga aaatttcctt actgtgaagc     1080

tacactcctc cagcagctgg ttcgaagcat tgctcctgtt gaaattggtt ctgatcccac     1140

tgcattctcc gtccttaccc aagccatcac tggccaggtg ggttttgtgg atgtggaatt     1200

ttgcactacc tgtggagaaa agggagcaag taaaagatgt tcagtttgca aaatggtaat     1260

atattgtgat caaacctgcc agaaaacaca ctggtttact cataagaaaa tctgtaagaa     1320

tctgaaggac atttacgaaa agcaacagtt ggaggctgcc aaagaaaaga gacaagagga     1380

aaaccacggc aaacttgatg tcaattctaa ctgtgttaat gaagagcaac cagaggctga     1440

agtaggtatc tctcaaaagg attccaatcc tgaagattcc ggggaaggaa agaaagaatc     1500

tcttgaaagc gaagctgagt tggaaggctt acaggatgct cctgcagggc cacaggtgtc     1560

tgaggagtaa aagccagagc aagtgccagt gtggatgatc ctcaccctgc aagaagctgg     1620

aaaactccta ggaatgcatt gtcctcacct tgttatacct gcgtggcacc atggcaggat     1680

tccacatttc atagaataca ggttttcaag caaacccctg ttgaccatgc cctaatttcc     1740

tattgatttc tgttctataa ttgaatggat attcctatgg aaaatttttt gtttcaaaat     1800

acaggaaaaa cattcctatt acctttctga ggctggcttt ccagcaattg tttcaaagga     1860

aaatagatcc ccttaaagaa aaaatacagg ctttagggaa caaagggaca agcagaacag     1920

gtgtggaaga gagattttca ggaagggaaa aatttatagc tacagagggt agttagaaaa     1980

atcataactt atatgtgaat aaaatacata taagcagcat ttacggtagt ggcattctac     2040

ttattaagat gcaatgaaat gaagaaaggc tttatgttca aggacctttg ccatagttca     2100

gctaattgta gttttatata gaaatgatcc tgaacactct gaacttgacg tagtcctgcg     2160

gtgatattct atctgcagta tttgtacctc cagaatggca gatccctcag caggaacaaa     2220

ggcatattga cggttctctc agcgtatgca ttaaaaaagg tacttcctga aacttttgat     2280

tcaataatga ctaaacatac tatgtacaca attactgtaa ggctaattca cgtgccatac     2340

tccacctgaa agcctgagtt atcttgctat aagcttttca tggagcactt cctttccaga     2400

aactgatttg taactcattt agagaatgtc ctggcgtcgg tttttagcat atgtggtatt     2460

taaacagagc tagaatgtga tgtctgaaga taatgctgca tttctgggtt tcttgtgtgg     2520

attttaaaat aaattgtgcc tacaaatata aacaaaaaaa aaaaaaa                   2567


<210>  12
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val His Ile Lys Lys Gly Glu Leu Thr Gln Glu Glu Lys Glu Leu 
1               5                   10                  15      


Leu Glu Val Ile Gly Lys Gly Thr Val Gln Glu Ala Gly Thr Leu Leu 
            20                  25                  30          


Ser Ser Lys Asn Val Arg Val Asn Cys Leu Asp Glu Asn Gly Met Thr 
        35                  40                  45              


Pro Leu Met His Ala Ala Tyr Lys Gly Lys Leu Asp Met Cys Lys Leu 
    50                  55                  60                  


Leu Leu Arg His Gly Ala Asp Val Asn Cys His Gln His Glu His Gly 
65                  70                  75                  80  


Tyr Thr Ala Leu Met Phe Ala Ala Leu Ser Gly Asn Lys Asp Ile Thr 
                85                  90                  95      


Trp Val Met Leu Glu Ala Gly Ala Glu Thr Asp Val Val Asn Ser Val 
            100                 105                 110         


Gly Arg Thr Ala Ala Gln Met Ala Ala Phe Val Gly Gln His Asp Cys 
        115                 120                 125             


Val Thr Ile Ile Asn Asn Phe Phe Pro Arg Glu Arg Leu Asp Tyr Tyr 
    130                 135                 140                 


Thr Lys Pro Gln Gly Leu Asp Lys Glu Pro Lys Leu Pro Pro Lys Leu 
145                 150                 155                 160 


Ala Gly Pro Leu His Lys Ile Ile Thr Thr Thr Asn Leu His Pro Val 
                165                 170                 175     


Lys Ile Val Met Leu Val Asn Glu Asn Pro Leu Leu Thr Glu Glu Ala 
            180                 185                 190         


Ala Leu Asn Lys Cys Tyr Arg Val Met Asp Leu Ile Cys Glu Lys Cys 
        195                 200                 205             


Met Lys Gln Arg Asp Met Asn Glu Val Leu Ala Met Lys Met His Tyr 
    210                 215                 220                 


Ile Ser Cys Ile Phe Gln Lys Cys Ile Asn Phe Leu Lys Asp Gly Glu 
225                 230                 235                 240 


Asn Lys Leu Asp Thr Leu Ile Lys Ser Leu Leu Lys Gly Arg Ala Ser 
                245                 250                 255     


Asp Gly Phe Pro Val Tyr Gln Glu Lys Ile Ile Arg Glu Ser Ile Arg 
            260                 265                 270         


Lys Phe Pro Tyr Cys Glu Ala Thr Leu Leu Gln Gln Leu Val Arg Ser 
        275                 280                 285             


Ile Ala Pro Val Glu Ile Gly Ser Asp Pro Thr Ala Phe Ser Val Leu 
    290                 295                 300                 


Thr Gln Ala Ile Thr Gly Gln Val Gly Phe Val Asp Val Glu Phe Cys 
305                 310                 315                 320 


Thr Thr Cys Gly Glu Lys Gly Ala Ser Lys Arg Cys Ser Val Cys Lys 
                325                 330                 335     


Met Val Ile Tyr Cys Asp Gln Thr Cys Gln Lys Thr His Trp Phe Thr 
            340                 345                 350         


His Lys Lys Ile Cys Lys Asn Leu Lys Asp Ile Tyr Glu Lys Gln Gln 
        355                 360                 365             


Leu Glu Ala Ala Lys Glu Lys Arg Gln Glu Glu Asn His Gly Lys Leu 
    370                 375                 380                 


Asp Val Asn Ser Asn Cys Val Asn Glu Glu Gln Pro Glu Ala Glu Val 
385                 390                 395                 400 


Gly Ile Ser Gln Lys Asp Ser Asn Pro Glu Asp Ser Gly Glu Gly Lys 
                405                 410                 415     


Lys Glu Ser Leu Glu Ser Glu Ala Glu Leu Glu Gly Leu Gln Asp Ala 
            420                 425                 430         


Pro Ala Gly Pro Gln Val Ser Glu Glu 
        435                 440     


<210>  13
<211>  2158
<212>  DNA
<213>  Homo sapiens

<400>  13
gccccaggtg cgcttcccct agagagggat tttccggtct cgtgggcaga ggaacaacca       60

ggaacttggg ctcagtctcc accccacagt ggggcggatc cgtcccggat aagacccgct      120

gtctggccct gagtagggtg tgacctccgc agccgcagag gaggagcgca gcccggcctc      180

gaagaacttc tgcttgggtg gctgaactct gatcttgacc tagagtcatg gccatggcaa      240

ccaaaggagg tactgtcaaa gctgcttcag gattcaatgc catggaagat gcccagaccc      300

tgaggaaggc catgaaaggg ctcggcaccg atgaagacgc cattattagc gtccttgcct      360

accgcaacac cgcccagcgc caggagatca ggacagccta caagagcacc atcggcaggg      420

acttgataga cgacctgaag tcagaactga gtggcaactt cgagcaggtg attgtgggga      480

tgatgacgcc cacggtgctg tatgacgtgc aagagctgcg aagggccatg aagggagccg      540

gcactgatga gggctgccta attgagatcc tggcctcccg gacccctgag gagatccggc      600

gcataagcca aacctaccag cagcaatatg gacggagcct tgaagatgac attcgctctg      660

acacatcgtt catgttccag cgagtgctgg tgtctctgtc agctggtggg agggatgaag      720

gaaattatct ggacgatgct ctcgtgagac aggatgccca ggacctgtat gaggctggag      780

agaagaaatg ggggacagat gaggtgaaat ttctaactgt tctctgttcc cggaaccgaa      840

atcacctgtt gcatgtgttt gatgaataca aaaggatatc acagaaggat attgaacaga      900

gtattaaatc tgaaacatct ggtagctttg aagatgctct gctggctata gtaaagtgca      960

tgaggaacaa atctgcatat tttgctgaaa agctctataa atcgatgaag ggcttgggca     1020

ccgatgataa caccctcatc agagtgatgg tttctcgagc agaaattgac atgttggata     1080

tccgggcaca cttcaagaga ctctatggaa agtctctgta ctcgttcatc aagggtgaca     1140

catctggaga ctacaggaaa gtactgcttg ttctctgtgg aggagatgat taaaataaaa     1200

atcccagaag gacaggagga ttctcaacac tttgaatttt tttaacttca tttttctaca     1260

ctgctattat cattatctca gaatgcttat ttccaattaa aacgcctaca gctgcctcct     1320

agaatataga ctgtctgtat tattattcac ctataattag tcattatgat gctttaaagc     1380

tgtacttgca tttcaaagct tataagatat aaatggagat tttaaagtag aaataaatat     1440

gtattccatg tttttaaaag attactttct actttgtgtt tcacagacat tgaatatatt     1500

aaattattcc atattttctt ttcagtgaaa aattttttaa atggaagact gttctaaaat     1560

cacttttttc cctaatccaa tttttagagt ggctagtagt ttcttcattt gaaattgtaa     1620

gcatccggtc agtaagaatg cccatccagt tttctatatt tcatagtcaa agccttgaaa     1680

gcatctacaa atctcttttt ttaggttttg tccatagcat cagttgatcc ttactaagtt     1740

tttcatggga gacttccttc atcacatctt atgttgaaat cactttctgt agtcaaagta     1800

taccaaaacc aatttatctg aactaaattc taaagtatgg ttatacaaac catatacatc     1860

tggttaccaa acataaatgc tgaacattcc atattattat agttaatgtc ttaatccagc     1920

ttgcaagtga atggaaaaaa aaataagctt caaactaggt attctgggaa tgatgtaatg     1980

ctctgaattt agtatgatat aaagaaaact tttttgtgct aaaaatactt tttaaaatca     2040

attttgttga ttgtagtaat ttctatttgc actgtgcctt tcaactccag aaacattctg     2100

aagatgtact tggatttaat taaaaagttc actttgtaag aaaaaaaaaa aaaaaaaa       2158


<210>  14
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp 
    


<210>  15
<211>  2135
<212>  DNA
<213>  Homo sapiens

<400>  15
aaagccgacc gagacggagc cgctgtcaac tctccaactc agctcagctg atcggttgcc       60

gccgccgccg ccgccagatt ctggaggcga agaacgcaaa gctgagaaca tggacgttaa      120

tatcgcccca ctccgcgcct gggacgattt cttcccgggt tccgatcgct ttgcccggcc      180

ggacttcagg gacatttcca aatggaacaa ccgcgtagtg agcaacctgc tctattacca      240

gaccaactac ctggtggtgg ctgccatgat gatttccatt gtggggtttc tgagtccctt      300

caacatgatc ctgggaggaa tcgtggtggt gctggtgttc acagggtttg tgtgggcagc      360

ccacaataaa gacgtccttc gccggatgaa gaagcgctac cccacgacgt tcgttatggt      420

ggtcatgttg gcgagctatt tccttatctc catgtttgga ggagtcatgg tctttgtgtt      480

tggcattact tttcctttgc tgttgatgtt tatccatgca tcgttgagac ttcggaacct      540

caagaacaaa ctggagaata aaatggaagg aataggtttg aagaggacac cgatgggcat      600

tgtcctggat gccctagaac agcaggaaga aggcatcaac agactcactg actatatcag      660

caaagtgaag gaataaacat aacttacctg agctagggtt gcagcagaaa ttgagttgca      720

gcttgccctt gtccagacct atgttctgct tgcgtttttg aaacaggagg tgcacgtacc      780

acccaattat ctatggcagc atgcatgtat aggccgaact attatcagct ctgatgtttc      840

agagagaaga cctcagaaac cgaaagaaaa ccaccaccct cctattgtgt ctgaagtttc      900

acgtgtgttt atgaaatcta atgggaaatg gatcacacga tttctttaag ggaattaaaa      960

aaaataaaag aattacggct tttacagcaa caatacgatt atcttatagg aaaaaaaaaa     1020

tcattgtaaa gtatcaagac aatacgagta aatgaaaagg ctgttaaagt agatgacatc     1080

atgtgttagc ctgttcctaa tcccctagaa ttgtaatgtg tgggatataa attagttttt     1140

attattctct taaaaatcaa agatgatctc tatcactttg ccacctgttt gatgtgcagt     1200

ggaaactggt taagccagtt gttcatactt cctttacaaa tataaagata gctgtttagg     1260

atattttgtt acatttttgt aaatttttga aatgctagta atgtgttttc accagcaagt     1320

atttgttgca aacttaatgt cattttcctt aagatggtta cagctatgta acctgtatta     1380

ttctggacgg acttattaaa atacaaacag acaaaaaata aaacaaaact tgagttctat     1440

ttaccttgca cattttttgt tgttacagtg aaaaaaatgg tccaagaaaa tgtttgccat     1500

ttttgcattg tttcgttttt aactggaaca tttagaaaga aggaaatgaa tgtgcatttt     1560

attaattcct taggggcaca aggaggacaa taatagctga tcttttgaaa tttgaaaaac     1620

gtctttagat gaccaagcaa aaagacttta aaaaatggta atgaaaatgg aatgcagcta     1680

ctgcagctaa taaaaaattt tagatagcaa ttgttacaac catatgcctt tatagctaga     1740

cattagaatt atgatagcat gagtttatac attctattat ttttcctccc tttctcatgt     1800

ttttataaat aggtaataaa aaatgttttg cctgccaatt gaatgatttc gtagctgaag     1860

tagaaacatt taggtttctg tagcattaaa ttgtgaagac aactggagtg gtacttactg     1920

aagaaactct ctgtatgtcc tagaataaga agcaatgatg tgctgcttct gatttttctt     1980

gcattttaaa ttctcagcca acctacagcc atgatcttta gcacagtgat atcaccatga     2040

cttcacagac atggtctaga atctgtaccc ttacccacat atgaagaata aaattgatta     2100

aaggtttttt tggtgagact ttatttaaaa aaaaa                                2135


<210>  16
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Thr 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210>  17
<211>  2071
<212>  DNA
<213>  Homo sapiens

<400>  17
aagggtcaca ggtcacgggg cggggccgag gcggaagcgc ccgcagcccg gtaccggctc       60

ctcctgggct ccctctagcg ccttcccccc ggcccgactc cgctggtcag cgccaagtga      120

cttacgcccc cgaccctgag cccggaccgc taggcgagga ggatcagatc tccgctcgag      180

aatctgaagg tgccctggtc ctggaggagt tccgtcccag cccgcggtct cccggtactg      240

tcgggccccg gccctctgga gcttcaggag gcggccgtca gggtcgggga gtatttgggt      300

ccggggtctc agggaagggc ggcgcctggg tctgcggtat cggaaagagc ctgctggagc      360

caagtagccc tccctctctt gggacagacc cctcggtccc atgtccatgg gggcaccgcg      420

gtccctcctc ctggccctgg ctgctggcct ggccgttgcc cgtccgccca acatcgtgct      480

gatctttgcc gacgacctcg gctatgggga cctgggctgc tatgggcacc ccagctctac      540

cactcccaac ctggaccagc tggcggcggg agggctgcgg ttcacagact tctacgtgcc      600

tgtgtctctg tgcacaccct ctagggccgc cctcctgacc ggccggctcc cggttcggat      660

gggcatgtac cctggcgtcc tggtgcccag ctcccggggg ggcctgcccc tggaggaggt      720

gaccgtggcc gaagtcctgg ctgcccgagg ctacctcaca ggaatggccg gcaagtggca      780

ccttggggtg gggcctgagg gggccttcct gcccccccat cagggcttcc atcgatttct      840

aggcatcccg tactcccacg accagggccc ctgccagaac ctgacctgct tcccgccggc      900

cactccttgc gacggtggct gtgaccaggg cctggtcccc atcccactgt tggccaacct      960

gtccgtggag gcgcagcccc cctggctgcc cggactagag gcccgctaca tggctttcgc     1020

ccatgacctc atggccgacg cccagcgcca ggatcgcccc ttcttcctgt actatgcctc     1080

tcaccacacc cactaccctc agttcagtgg gcagagcttt gcagagcgtt caggccgcgg     1140

gccatttggg gactccctga tggagctgga tgcagctgtg gggaccctga tgacagccat     1200

aggggacctg gggctgcttg aagagacgct ggtcatcttc actgcagaca atggacctga     1260

gaccatgcgt atgtcccgag gcggctgctc cggtctcttg cggtgtggaa agggaacgac     1320

ctacgagggc ggtgtccgag agcctgcctt ggccttctgg ccaggtcata tcgctcccgg     1380

cgtgacccac gagctggcca gctccctgga cctgctgcct accctggcag ccctggctgg     1440

ggccccactg cccaatgtca ccttggatgg ctttgacctc agccccctgc tgctgggcac     1500

aggcaagagc cctcggcagt ctctcttctt ctacccgtcc tacccagacg aggtccgtgg     1560

ggtttttgct gtgcggactg gaaagtacaa ggctcacttc ttcacccagg gctctgccca     1620

cagtgatacc actgcagacc ctgcctgcca cgcctccagc tctctgactg ctcatgagcc     1680

cccgctgctc tatgacctgt ccaaggaccc tggtgagaac tacaacctgc tggggggtgt     1740

ggccggggcc accccagagg tgctgcaagc cctgaaacag cttcagctgc tcaaggccca     1800

gttagacgca gctgtgacct tcggccccag ccaggtggcc cggggcgagg accccgccct     1860

gcagatctgc tgtcatcctg gctgcacccc ccgcccagct tgctgccatt gcccagatcc     1920

ccatgcctga gggcccctcg gctggcctgg gcatgtgatg gctcctcact gggagcctgt     1980

gggggaggct caggtgtctg gagggggttt gtgcctgata acgtaataac accagtggag     2040

acttgcagat gtgaaaaaaa aaaaaaaaaa a                                    2071


<210>  18
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  19
<211>  1966
<212>  DNA
<213>  Homo sapiens

<400>  19
aagggtcaca ggtcacgggg cggggccgag gcggaagcgc ccgcagcccg gtaccggctc       60

ctcctgggct ccctctagcg ccttcccccc ggcccgactc cgctggtcag cgccaagtga      120

cttacgcccc cgaccctgag cccggaccgc taggcgagga ggatcagatc tccgctcgag      180

aatctgaagg tgccctggtc ctggaggagt tccgtcccag cccgcggtct cccggtactg      240

tcgggccccg gccctctgga gcttcaggag gcggccgtca ggacccctcg gtcccatgtc      300

catgggggca ccgcggtccc tcctcctggc cctggctgct ggcctggccg ttgcccgtcc      360

gcccaacatc gtgctgatct ttgccgacga cctcggctat ggggacctgg gctgctatgg      420

gcaccccagc tctaccactc ccaacctgga ccagctggcg gcgggagggc tgcggttcac      480

agacttctac gtgcctgtgt ctctgtgcac accctctagg gccgccctcc tgaccggccg      540

gctcccggtt cggatgggca tgtaccctgg cgtcctggtg cccagctccc gggggggcct      600

gcccctggag gaggtgaccg tggccgaagt cctggctgcc cgaggctacc tcacaggaat      660

ggccggcaag tggcaccttg gggtggggcc tgagggggcc ttcctgcccc cccatcaggg      720

cttccatcga tttctaggca tcccgtactc ccacgaccag ggcccctgcc agaacctgac      780

ctgcttcccg ccggccactc cttgcgacgg tggctgtgac cagggcctgg tccccatccc      840

actgttggcc aacctgtccg tggaggcgca gcccccctgg ctgcccggac tagaggcccg      900

ctacatggct ttcgcccatg acctcatggc cgacgcccag cgccaggatc gccccttctt      960

cctgtactat gcctctcacc acacccacta ccctcagttc agtgggcaga gctttgcaga     1020

gcgttcaggc cgcgggccat ttggggactc cctgatggag ctggatgcag ctgtggggac     1080

cctgatgaca gccatagggg acctggggct gcttgaagag acgctggtca tcttcactgc     1140

agacaatgga cctgagacca tgcgtatgtc ccgaggcggc tgctccggtc tcttgcggtg     1200

tggaaaggga acgacctacg agggcggtgt ccgagagcct gccttggcct tctggccagg     1260

tcatatcgct cccggcgtga cccacgagct ggccagctcc ctggacctgc tgcctaccct     1320

ggcagccctg gctggggccc cactgcccaa tgtcaccttg gatggctttg acctcagccc     1380

cctgctgctg ggcacaggca agagccctcg gcagtctctc ttcttctacc cgtcctaccc     1440

agacgaggtc cgtggggttt ttgctgtgcg gactggaaag tacaaggctc acttcttcac     1500

ccagggctct gcccacagtg ataccactgc agaccctgcc tgccacgcct ccagctctct     1560

gactgctcat gagcccccgc tgctctatga cctgtccaag gaccctggtg agaactacaa     1620

cctgctgggg ggtgtggccg gggccacccc agaggtgctg caagccctga aacagcttca     1680

gctgctcaag gcccagttag acgcagctgt gaccttcggc cccagccagg tggcccgggg     1740

cgaggacccc gccctgcaga tctgctgtca tcctggctgc accccccgcc cagcttgctg     1800

ccattgccca gatccccatg cctgagggcc cctcggctgg cctgggcatg tgatggctcc     1860

tcactgggag cctgtggggg aggctcaggt gtctggaggg ggtttgtgcc tgataacgta     1920

ataacaccag tggagacttg cagatgtgaa aaaaaaaaaa aaaaaa                    1966


<210>  20
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  21
<211>  1918
<212>  DNA
<213>  Homo sapiens

<400>  21
aagggtcaca ggtcacgggg cggggccgag gcggaagcgc ccgcagcccg gtaccggctc       60

ctcctgggct ccctctagcg ccttcccccc ggcccgactc cgctggtcag cgccaagtga      120

cttacgcccc cgaccctgag cccggaccgc taggcgagga ggatcagatc tccgctcgag      180

aatctgaagg tgccctggtc ctggaggagt tccgtcccag cccgcggtct cccgacccct      240

cggtcccatg tccatggggg caccgcggtc cctcctcctg gccctggctg ctggcctggc      300

cgttgcccgt ccgcccaaca tcgtgctgat ctttgccgac gacctcggct atggggacct      360

gggctgctat gggcacccca gctctaccac tcccaacctg gaccagctgg cggcgggagg      420

gctgcggttc acagacttct acgtgcctgt gtctctgtgc acaccctcta gggccgccct      480

cctgaccggc cggctcccgg ttcggatggg catgtaccct ggcgtcctgg tgcccagctc      540

ccgggggggc ctgcccctgg aggaggtgac cgtggccgaa gtcctggctg cccgaggcta      600

cctcacagga atggccggca agtggcacct tggggtgggg cctgaggggg ccttcctgcc      660

cccccatcag ggcttccatc gatttctagg catcccgtac tcccacgacc agggcccctg      720

ccagaacctg acctgcttcc cgccggccac tccttgcgac ggtggctgtg accagggcct      780

ggtccccatc ccactgttgg ccaacctgtc cgtggaggcg cagcccccct ggctgcccgg      840

actagaggcc cgctacatgg ctttcgccca tgacctcatg gccgacgccc agcgccagga      900

tcgccccttc ttcctgtact atgcctctca ccacacccac taccctcagt tcagtgggca      960

gagctttgca gagcgttcag gccgcgggcc atttggggac tccctgatgg agctggatgc     1020

agctgtgggg accctgatga cagccatagg ggacctgggg ctgcttgaag agacgctggt     1080

catcttcact gcagacaatg gacctgagac catgcgtatg tcccgaggcg gctgctccgg     1140

tctcttgcgg tgtggaaagg gaacgaccta cgagggcggt gtccgagagc ctgccttggc     1200

cttctggcca ggtcatatcg ctcccggcgt gacccacgag ctggccagct ccctggacct     1260

gctgcctacc ctggcagccc tggctggggc cccactgccc aatgtcacct tggatggctt     1320

tgacctcagc cccctgctgc tgggcacagg caagagccct cggcagtctc tcttcttcta     1380

cccgtcctac ccagacgagg tccgtggggt ttttgctgtg cggactggaa agtacaaggc     1440

tcacttcttc acccagggct ctgcccacag tgataccact gcagaccctg cctgccacgc     1500

ctccagctct ctgactgctc atgagccccc gctgctctat gacctgtcca aggaccctgg     1560

tgagaactac aacctgctgg ggggtgtggc cggggccacc ccagaggtgc tgcaagccct     1620

gaaacagctt cagctgctca aggcccagtt agacgcagct gtgaccttcg gccccagcca     1680

ggtggcccgg ggcgaggacc ccgccctgca gatctgctgt catcctggct gcaccccccg     1740

cccagcttgc tgccattgcc cagatcccca tgcctgaggg cccctcggct ggcctgggca     1800

tgtgatggct cctcactggg agcctgtggg ggaggctcag gtgtctggag ggggtttgtg     1860

cctgataacg taataacacc agtggagact tgcagatgtg aaaaaaaaaa aaaaaaaa       1918


<210>  22
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  23
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  23
aagggtcaca ggtcacgggg cggggccgag gcggaagcgc ccgcagcccg gtaccggctc       60

ctcctgggct ccctctagcg ccttcccccc ggcccgactc cgctggtcag cgccaagtga      120

cttacgcccc cgaccctgag cccggaccgc taggcgagga ggatcagatc tccgctcgag      180

aatctgaaga cccctcggtc ccatgtccat gggggcaccg cggtccctcc tcctggccct      240

ggctgctggc ctggccgttg cccgtccgcc caacatcgtg ctgatctttg ccgacgacct      300

cggctatggg gacctgggct gctatgggca ccccagctct accactccca acctggacca      360

gctggcggcg ggagggctgc ggttcacaga cttctacgtg cctgtgtctc tgtgcacacc      420

ctctagggcc gccctcctga ccggccggct cccggttcgg atgggcatgt accctggcgt      480

cctggtgccc agctcccggg ggggcctgcc cctggaggag gtgaccgtgg ccgaagtcct      540

ggctgcccga ggctacctca caggaatggc cggcaagtgg caccttgggg tggggcctga      600

gggggccttc ctgccccccc atcagggctt ccatcgattt ctaggcatcc cgtactccca      660

cgaccagggc ccctgccaga acctgacctg cttcccgccg gccactcctt gcgacggtgg      720

ctgtgaccag ggcctggtcc ccatcccact gttggccaac ctgtccgtgg aggcgcagcc      780

cccctggctg cccggactag aggcccgcta catggctttc gcccatgacc tcatggccga      840

cgcccagcgc caggatcgcc ccttcttcct gtactatgcc tctcaccaca cccactaccc      900

tcagttcagt gggcagagct ttgcagagcg ttcaggccgc gggccatttg gggactccct      960

gatggagctg gatgcagctg tggggaccct gatgacagcc ataggggacc tggggctgct     1020

tgaagagacg ctggtcatct tcactgcaga caatggacct gagaccatgc gtatgtcccg     1080

aggcggctgc tccggtctct tgcggtgtgg aaagggaacg acctacgagg gcggtgtccg     1140

agagcctgcc ttggccttct ggccaggtca tatcgctccc ggcgtgaccc acgagctggc     1200

cagctccctg gacctgctgc ctaccctggc agccctggct ggggccccac tgcccaatgt     1260

caccttggat ggctttgacc tcagccccct gctgctgggc acaggcaaga gccctcggca     1320

gtctctcttc ttctacccgt cctacccaga cgaggtccgt ggggtttttg ctgtgcggac     1380

tggaaagtac aaggctcact tcttcaccca gggctctgcc cacagtgata ccactgcaga     1440

ccctgcctgc cacgcctcca gctctctgac tgctcatgag cccccgctgc tctatgacct     1500

gtccaaggac cctggtgaga actacaacct gctggggggt gtggccgggg ccaccccaga     1560

ggtgctgcaa gccctgaaac agcttcagct gctcaaggcc cagttagacg cagctgtgac     1620

cttcggcccc agccaggtgg cccggggcga ggaccccgcc ctgcagatct gctgtcatcc     1680

tggctgcacc ccccgcccag cttgctgcca ttgcccagat ccccatgcct gagggcccct     1740

cggctggcct gggcatgtga tggctcctca ctgggagcct gtgggggagg ctcaggtgtc     1800

tggagggggt ttgtgcctga taacgtaata acaccagtgg agacttgcag atgtgaaaaa     1860

aaaaaaaaaa aaa                                                        1873


<210>  24
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  25
<211>  1681
<212>  DNA
<213>  Homo sapiens

<400>  25
aagggtcaca ggtcacgggg cggggccgag gcggaagcgc ccgcagcccg gtaccggctc       60

ctcctgggct ccctctagcg ccttcccccc ggcccgactc cgctggtcag cgccaagtga      120

cttacgcccc cgaccctgag cccggaccgc taggcgagga ggatcagatc tccgctcgag      180

aatctgaagg tgccctggtc ctggaggagt tccgtcccag cccgcggtct cccgggccgc      240

cctcctgacc ggccggctcc cggttcggat gggcatgtac cctggcgtcc tggtgcccag      300

ctcccggggg ggcctgcccc tggaggaggt gaccgtggcc gaagtcctgg ctgcccgagg      360

ctacctcaca ggaatggccg gcaagtggca ccttggggtg gggcctgagg gggccttcct      420

gcccccccat cagggcttcc atcgatttct aggcatcccg tactcccacg accagggccc      480

ctgccagaac ctgacctgct tcccgccggc cactccttgc gacggtggct gtgaccaggg      540

cctggtcccc atcccactgt tggccaacct gtccgtggag gcgcagcccc cctggctgcc      600

cggactagag gcccgctaca tggctttcgc ccatgacctc atggccgacg cccagcgcca      660

ggatcgcccc ttcttcctgt actatgcctc tcaccacacc cactaccctc agttcagtgg      720

gcagagcttt gcagagcgtt caggccgcgg gccatttggg gactccctga tggagctgga      780

tgcagctgtg gggaccctga tgacagccat aggggacctg gggctgcttg aagagacgct      840

ggtcatcttc actgcagaca atggacctga gaccatgcgt atgtcccgag gcggctgctc      900

cggtctcttg cggtgtggaa agggaacgac ctacgagggc ggtgtccgag agcctgcctt      960

ggccttctgg ccaggtcata tcgctcccgg cgtgacccac gagctggcca gctccctgga     1020

cctgctgcct accctggcag ccctggctgg ggccccactg cccaatgtca ccttggatgg     1080

ctttgacctc agccccctgc tgctgggcac aggcaagagc cctcggcagt ctctcttctt     1140

ctacccgtcc tacccagacg aggtccgtgg ggtttttgct gtgcggactg gaaagtacaa     1200

ggctcacttc ttcacccagg gctctgccca cagtgatacc actgcagacc ctgcctgcca     1260

cgcctccagc tctctgactg ctcatgagcc cccgctgctc tatgacctgt ccaaggaccc     1320

tggtgagaac tacaacctgc tggggggtgt ggccggggcc accccagagg tgctgcaagc     1380

cctgaaacag cttcagctgc tcaaggccca gttagacgca gctgtgacct tcggccccag     1440

ccaggtggcc cggggcgagg accccgccct gcagatctgc tgtcatcctg gctgcacccc     1500

ccgcccagct tgctgccatt gcccagatcc ccatgcctga gggcccctcg gctggcctgg     1560

gcatgtgatg gctcctcact gggagcctgt gggggaggct caggtgtctg gagggggttt     1620

gtgcctgata acgtaataac accagtggag acttgcagat gtgaaaaaaa aaaaaaaaaa     1680

a                                                                     1681


<210>  26
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser Arg Gly Gly Leu 
1               5                   10                  15      


Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala Ala Arg Gly Tyr 
            20                  25                  30          


Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val Gly Pro Glu Gly 
        35                  40                  45              


Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe Leu Gly Ile Pro 
    50                  55                  60                  


Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr Cys Phe Pro Pro 
65                  70                  75                  80  


Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu Val Pro Ile Pro 
                85                  90                  95      


Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro Trp Leu Pro Gly 
            100                 105                 110         


Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu Met Ala Asp Ala 
        115                 120                 125             


Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala Ser His His Thr 
    130                 135                 140                 


His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu Arg Ser Gly Arg 
145                 150                 155                 160 


Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala Ala Val Gly Thr 
                165                 170                 175     


Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu Glu Thr Leu Val 
            180                 185                 190         


Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg Met Ser Arg Gly 
        195                 200                 205             


Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr Thr Tyr Glu Gly 
    210                 215                 220                 


Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly His Ile Ala Pro 
225                 230                 235                 240 


Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu Leu Pro Thr Leu 
                245                 250                 255     


Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr Leu Asp Gly Phe 
            260                 265                 270         


Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser Pro Arg Gln Ser 
        275                 280                 285             


Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg Gly Val Phe Ala 
    290                 295                 300                 


Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr Gln Gly Ser Ala 
305                 310                 315                 320 


His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala Ser Ser Ser Leu 
                325                 330                 335     


Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser Lys Asp Pro Gly 
            340                 345                 350         


Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala Thr Pro Glu Val 
        355                 360                 365             


Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala Gln Leu Asp Ala 
    370                 375                 380                 


Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly Glu Asp Pro Ala 
385                 390                 395                 400 


Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg Pro Ala Cys Cys 
                405                 410                 415     


His Cys Pro Asp Pro His Ala 
            420             


<210>  27
<211>  5873
<212>  DNA
<213>  Homo sapiens

<400>  27
gaaaaatgct tcctgtttct ttaaaggcgc tcgcggctcg ggcggcccgg gctggggagg       60

cggtggcggc gggagctgcc tcctctccgg gcggcggcgc tgactgatct cgcgaactgg      120

gcttctgtgt aaactgaggc taaacaaaca cagatggagc gcagcgggcg ttctccagaa      180

atgctggcaa ggaggcagcg acttcagatg acactctgag cgctccggga acggacagcc      240

cggcggcttc ccgaagccgg cggcgcagct gcccggggcg agggggagaa agggagagag      300

ggagggggag ggcgggcgaa gcgggagagc cagagactcc tcggcgctga gcgcggcggc      360

ggcccgggca gccccacgcc cctgcctcgc gcgccgcccg cgccatgaag cacatcccgg      420

tcctcgagga cgggccgtgg aagaccgtgt gcgtgaagga gctgaacggc cttaagaagc      480

tcaagcggaa aggcaaggag ccggcgcggc gcgcgaacgg ctataaaact ttccgactgg      540

acttggaagc gcccgagccc cgcgccgtag ccaccaacgg gctgcgggac aggacccatc      600

ggctgcagcc ggtcccggta ccggtgccgg tgccagtccc agtggcgccg gccgttcccc      660

caagaggggg cacggacaca gccggggagc gcgggggctc tcgggcgccc gaggtctccg      720

acgcgcggaa acgctgcttc gccctaggcg cagtggggcc aggactcccc acgccgccgc      780

cgccgccgcc tcctgcgccc cagagccagg cacctggggg cccagaggca cagcctttcc      840

gggagccggg tctgcgtcct cgcatcttgc tgtgcgcacc gcccgcgcgc cccgcgccgt      900

cagcaccccc agcaccgcca gcgcccccgg agtccactgt gcgccctgcg cccccgacgc      960

gccccgggga aagttcctac tcgtcaattt cacacgtaat ttacaataac caccaggatt     1020

cctccgcgtc gcctaggaaa cgaccgggcg aagcgactgc cgcctcctcc gagatcaaag     1080

ccctgcagca gacccggagg ctcctggcga acgccaggga gcggacgcgg gtgcacacca     1140

tcagcgcagc cttcgaggcg ctcaggaagc aggtgccgtg ctactcatat gggcagaagc     1200

tgtccaaact ggccatcctg aggatcgcct gtaactacat cctgtccctg gcgcggctgg     1260

ctgaccttga ctacagtgcc gaccacagca acctcagctt ctccgagtgt gtgcagcgct     1320

gcacccgcac cctgcaggcc gagggacgtg ccaagaagcg caaggagtga ctggctgcag     1380

gcaagaccaa ggccaccact gtgggccctc cttccagtca ggcctgagga caaggtgagc     1440

tcgctgagtc cagcctcgtg gtcttctcca agatgccgcc agatgcccag cctacagcct     1500

ctcagggtcg gatcggagca cgcctgcctc cctctcccct ccgccctcac ccagccaatc     1560

cgaggctgct tcgcactttg ccctctgcct ggtggggagg ggagagctca gcccccgact     1620

cactcagacc ccaaggccca ctgtccagct gcagaaattc gttgccaaag attggacaga     1680

gacaccgaag gaaatggggt ggtgaaaccc cacagcgaaa agccacaccg ttgctctgtg     1740

acttttgctc ctcctgttgc ctgagcccca tctcaagcca aagatgagtc agtggttctg     1800

ctaggaactc atggaatgga tgggcatttg atgacccctg ggggtcatct tggccctctg     1860

acctggtgct ctctctccac tgggccttgt gctggctgag tgcaagacaa gccttagggg     1920

ctgtgagagg gaggctgggg tgcctgggcg gggctgggag tgggacctga gatccctgcc     1980

cactctctcc ccttcattgg ctgcccaggc cactggcccc agttctcagt gtcccttggg     2040

tccaggctcc ttgggcccta agcatcacca gaagggagta agcagggaga gaagcaatat     2100

tactccctcc cctacaccag ggacttgccc cagggcagct acctatgggt ctttgcttcc     2160

ccagccagcc tctcctcact gtgacccacc cccatgggcc cccgtcccag gcagccagca     2220

ccatgggcag gccctgccat ggacagaaaa agagtttttc tcttgttcag cctgcacgtg     2280

gcctgaggaa ggagtagagg ctgggttggc tggagccgtc ctactgggca agatggcgcc     2340

ccacttggag ggcggtggtc tgttacaggg tgtgcagggg cagagaagga agggaccagg     2400

ggactgggcc agtatgtgga ggatggggcc tgcgtgttca aagccaaggc ccgccccttc     2460

cttgtgctca aatggccaaa gctgttcacg tctgtgctca accatctgct tcaaattgaa     2520

gtaaaagccc caaaatgtca agaaaatact tgtgttgagt ggactctgtg ggtgaccagg     2580

actttggccg gtcatcagct ggggagtgtg agggaggggg ttggtttcta cctacaggtt     2640

gagagccctt caggatcagg cgctgtccga gtgagagtgt gtgtgtctgt gtgtggaagg     2700

gggtggaggg cggttcccac agtagtctca gcctggacta gtgaccagga ggcctggtca     2760

ggaacacatg aggagccctc tctgtccgca ctgcactcaa tctgtaccat ggatttatga     2820

gataggggcc cctattatta accccgtttc acagatgggg taactgaggc ctcaagtaga     2880

cagggtcagt cggtgacaga gccagtcatc gaatcaggat gggctcactt caaatcctgt     2940

gctctcaaac cttttccagc cccatcacca gtcccagccc aaagtctctt gtgtggcctt     3000

gtcacattgc ttcacctcag cgggcctaag gtagggacaa taaaggccca ttgggactgg     3060

gggaaggggt gataagataa aaaataggag agcactgtca aggcagaagg gacagggctg     3120

gccaaggaaa gggggatagg aggggaccgg aggctgcagc catacaggac acagtttgtc     3180

ccttggtttc accagtgtca ctttctcgtc tctgctgctc agactcctgg gctgggctgg     3240

ggctggctgc agggagcccc ccttgcagta gcgtttctca ggctggccct ttaccaagga     3300

ccacagtgtc catgctgtct tggatcccta ggctggcaca gaaacagggg acccaggtgg     3360

ccctgagcac tcctcagagc aaaggtgctc tggaagcaga ctggacagag tgggcatgga     3420

atggggccag gagggtctgt taggaaggtt cagccaccct gtgaagctgg cacagataac     3480

agcactgctc tgttgtccct cggagcctct gagtaaccct gatggcactt cctaaggcag     3540

caggacatgt ggactgacca gcatcaaact gttgacatag aagaccattt ctattaccaa     3600

agggagtgta ccccattctg ctgccaaggg agcaaaccca tggccttacc acccagaaag     3660

agcccatcct ccacctccca tccccctcct gcatacatac ttcattacat gtttcccttt     3720

cattctgaag catcattgat gaccagctgc ctgtcagaca ctaagatagg cagtgggaat     3780

gaagagatgg atcttgtgtc atgcatggca tcacggagct ctgggttctg tacggagggt     3840

gggacagaca ggtagacaag caaataatta tgattatagc agatgactaa ggtgttgtcg     3900

ggagcttcag gaaaggaaga actaactctt ggggaggttc tcaggaagga tttccctgga     3960

aagtagccat gggacttgcg tcttaaatgg tgagtaaaag ctttctgagc aggggagtag     4020

gaaaagggct ttctatgcag aggagcactc agcgctggca ggaaattgga atcacccaag     4080

gagattatta aatattaaat attgatatga agtattgatg cccaatttca tctccagaaa     4140

ttctgatgta ttggtctagg gtgttgcctg gtcattggga tttttacaag ctcctcaagt     4200

gatcttaatg tgcaggcaag gttgaagccg ctggtctaag tggggtctgg tctacgataa     4260

gaaagtgact ttgagccatc gatttgggag acaggctctg ggtggatgtg tgtgtgtgca     4320

cacatatgta tgtatgtgga tgactaaaag tgcatgctct cctctccttt cccagcttcc     4380

tctccagcac agcaacttgt gttcgtatgc acacacatgc atactctctc tcatgggcac     4440

atgcataccc acacacacac tcgtgtacat ttccagaaaa tggaattaca tttcagatag     4500

attcagattc caacggcagt cttctaaaca cttttatgca agcagccatt caaggagacc     4560

ctcagcaaaa tataaatgac gaggagctgc cctcatgggg ccctgtgaaa gcactttgca     4620

gtccagcctt gggtttgtgg tcacagagtc acctgtggat gtttgtagca cactctcctt     4680

gtcttgtctg ctctgggtca ccaggcacag gccataaagg gatgaggggg ccctctccag     4740

ggacccgcaa gatcttcctg ggtatgtctg catgaagccc cacgtgtgca cacccatctt     4800

catgtgtgtg tgtgccagcc tcctgctctc tgcagaacaa aaccagaagg aatggctctg     4860

ggagttggag atctcagctc acaggccaag ctttgcaaga ctctccaaag actgcccaca     4920

gactgtgctg cttcctgggt ctggcctgag actatcccag aagagagggt taaattctgg     4980

aggtgaggtt ttgagcaagt gttcatcccc ccacactatg ctccttcctg tctccatggc     5040

cacatccttc aaggctctgt gctgttctct ttttttctgg atttctccac ctccaccaag     5100

ttcccctttc tcacagctag tggaggcatg agtaggcagg tcccaggggc tgggaactgg     5160

gtagcattgc catgtgcagg gactgtgttg ggagctgcag gtacagagct cctctgtgct     5220

caagagcttg ccggtgagcc tggacggagg cataggtgca gctaattagg ataagacagg     5280

ggccgcgctg tggtcagccg tgggaagccg gcgaggggac tggagttggg gctacacttg     5340

cctccctcct atgctgcttc ctgagccacg aagtggtcat tgccagcatc ccaggcaaca     5400

aacagcaaga ctcagacatc tccaaggaaa ccctttgagt ggatctgtac cgttgttctc     5460

gtcttgctct cttgctgccc tgccaccttc acagctgctt tctgtttcct ggttccagga     5520

agacagcggg gcacagggtc cctgctttgt gaggagcagc tggcttctcc ctttgccccc     5580

aggttttgcc ctcccacatg tctcccttct ggtgacccgg accccagaca aactatgcct     5640

gcctccctga agccaggcat cctgaggaac ttgatagaca aacaatgaca gtgttttcca     5700

gaactgtggg tacgtgtcta atctcagatg gtactatgaa ttcctggaga tcaaagtttg     5760

gatctaattc aacccctgat cctcgaaacg gctttcttgc aaagtgtata tattggtttc     5820

tttgctgaat gaatgaataa aacatggaaa atgtggtaat tcaaaaaaaa aaa            5873


<210>  28
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys His Ile Pro Val Leu Glu Asp Gly Pro Trp Lys Thr Val Cys 
1               5                   10                  15      


Val Lys Glu Leu Asn Gly Leu Lys Lys Leu Lys Arg Lys Gly Lys Glu 
            20                  25                  30          


Pro Ala Arg Arg Ala Asn Gly Tyr Lys Thr Phe Arg Leu Asp Leu Glu 
        35                  40                  45              


Ala Pro Glu Pro Arg Ala Val Ala Thr Asn Gly Leu Arg Asp Arg Thr 
    50                  55                  60                  


His Arg Leu Gln Pro Val Pro Val Pro Val Pro Val Pro Val Pro Val 
65                  70                  75                  80  


Ala Pro Ala Val Pro Pro Arg Gly Gly Thr Asp Thr Ala Gly Glu Arg 
                85                  90                  95      


Gly Gly Ser Arg Ala Pro Glu Val Ser Asp Ala Arg Lys Arg Cys Phe 
            100                 105                 110         


Ala Leu Gly Ala Val Gly Pro Gly Leu Pro Thr Pro Pro Pro Pro Pro 
        115                 120                 125             


Pro Pro Ala Pro Gln Ser Gln Ala Pro Gly Gly Pro Glu Ala Gln Pro 
    130                 135                 140                 


Phe Arg Glu Pro Gly Leu Arg Pro Arg Ile Leu Leu Cys Ala Pro Pro 
145                 150                 155                 160 


Ala Arg Pro Ala Pro Ser Ala Pro Pro Ala Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Ser Thr Val Arg Pro Ala Pro Pro Thr Arg Pro Gly Glu Ser Ser Tyr 
            180                 185                 190         


Ser Ser Ile Ser His Val Ile Tyr Asn Asn His Gln Asp Ser Ser Ala 
        195                 200                 205             


Ser Pro Arg Lys Arg Pro Gly Glu Ala Thr Ala Ala Ser Ser Glu Ile 
    210                 215                 220                 


Lys Ala Leu Gln Gln Thr Arg Arg Leu Leu Ala Asn Ala Arg Glu Arg 
225                 230                 235                 240 


Thr Arg Val His Thr Ile Ser Ala Ala Phe Glu Ala Leu Arg Lys Gln 
                245                 250                 255     


Val Pro Cys Tyr Ser Tyr Gly Gln Lys Leu Ser Lys Leu Ala Ile Leu 
            260                 265                 270         


Arg Ile Ala Cys Asn Tyr Ile Leu Ser Leu Ala Arg Leu Ala Asp Leu 
        275                 280                 285             


Asp Tyr Ser Ala Asp His Ser Asn Leu Ser Phe Ser Glu Cys Val Gln 
    290                 295                 300                 


Arg Cys Thr Arg Thr Leu Gln Ala Glu Gly Arg Ala Lys Lys Arg Lys 
305                 310                 315                 320 


Glu 
    


<210>  29
<211>  4567
<212>  DNA
<213>  Homo sapiens

<400>  29
gacagcctct gggtcctcgg tcggtacagt ctctgcacct cgcgccccag caggtaaact       60

aacattatgg atttttccaa gctacccaaa atactcgatg aagataaaga aagcacattt      120

ggttatgtgc atggggtctc aggacctgtg gttacagcct gtgacatggc gggtgcagcc      180

atgtatgagc tggtgagagt gggccacagc gaattggttg gagagattat tcgattggag      240

ggtgacatgg ctactattca ggtgtatgaa gaaacttctg gtgtgtctgt tggagatcct      300

gtacttcgca ctggtaaacc cctctctgta gagcttggtc ctggcattat gggagccatt      360

tttgatggta ttcaaagacc tttgtcggat atcagcagtc agacccaaag catctacatc      420

cccagaggag taaacgtgtc tgctcttagc agagatatca aatgggactt tacaccttgc      480

aaaaacctac gggttggtag tcatatcact ggcggagaca tttatggaat tgtcagtgag      540

aactcgctta tcaaacacaa aatcatgtta cccccacgaa acagaggaac tgtaacttac      600

attgctccac ctgggaatta tgatacctct gatgttgtct tggagcttga atttgaaggt      660

gtaaaggaga agttcaccat ggtgcaagta tggcctgtac gtcaagttcg acctgtcact      720

gagaagctgc cagccaatca tcctctgttg actggccaga gagtccttga tgcccttttt      780

ccgtgtgtcc agggaggaac tactgctatc cctggagcct ttggctgtgg aaagacagtg      840

atatcacagt ctctatccaa gtattctaac agtgatgtaa tcatctatgt aggatgtggt      900

gaaagaggaa atgagatgtc tgaagtcctc cgggacttcc cagagctcac aatggaggtt      960

gatggtaagg tagagtcaat tatgaagagg acagctttgg tagccaatac ctccaatatg     1020

cctgttgctg ctagagaagc ctctatttat actggaatca cactgtcaga gtacttccgt     1080

gacatgggct atcatgtcag tatgatggct gactctacct ctagatgggc tgaggccctt     1140

agagaaatct ctggtcgttt agctgaaatg cctgcagata gtggatatcc agcctatctt     1200

ggtgcccgtc tggcctcgtt ttatgaacga gcaggcaggg tgaaatgtct tggaaatcct     1260

gaaagagaag ggagtgtcag cattgtagga gcagtttctc cacctggtgg tgatttttct     1320

gatccagtta catctgccac tcttggtatc gttcaggtgt tctggggctt agataagaaa     1380

ctagctcaac gtaagcattt cccctctgtc aattggctca tcagctacag caagtatatg     1440

cgtgccttgg atgaatacta tgacaaacac ttcacagagt tcgttcctct gaggacgaaa     1500

gctaaggaaa ttctgcagga agaagaagac ctggcagaaa ttgtacagct tgtgggaaag     1560

gcttctttgg cagaaacaga taaaatcact ctggaggtag caaaacttat caaagatgat     1620

ttcctacaac aaaatggata tactccttat gacaggttct gcccattcta caagacagta     1680

gggatgctgt ccaacatgat tgcattttat gatatggctc gtagagctgt tgaaaccact     1740

gcccagagtg acaataaaat cacatggtcc attattcgtg agcacatggg agacatcctc     1800

tataaacttt cctccatgaa attcaaggat ccactgaaag atggtgaggc aaagatcaaa     1860

agcgactatg cacaacttct tgaagacatg cagaatgcat tccgtagcct tgaagattag     1920

aagccttgaa gattacaact gtgatttcct tttcctcagc aagctcctat gtgtatattt     1980

tcctgaattt ctcatctcaa accctttgct tctttattgt gcagctttga gactagtgcc     2040

tatgtgtgtt atttgtttcc ctgttttttt ggtaggtctt atataaaaca aacattcctt     2100

tgttctagtg ttgtgaaggg cctccctctt cctttatctg aagtggtgaa tatagtaaat     2160

atacattctg gttacactac tgtaaacttg tatgtagggt gatgaccctc tttgtcctag     2220

gtgtaccctt tcctcatctc tattaaattg taaacaggac tactgcatgt actctctttg     2280

cagtgaattt ggaatggaag gccaggtttc tataactttt gaacaggtac tttgtgaaat     2340

gactcaattt ctattgtggt aagctcattg gcagcttagc attttgcaaa ggaattgctt     2400

tgcaggaaat atttaatttt caaaaacata atgattaatg ttccaattat gcatcacttc     2460

ccccagtata aatcaggaat gtttgtgaga aaccattggg aactatactc tttttatttt     2520

tattttttat tttttttatt attttttttt tggggacgga gtgtccctct tgttgcccag     2580

gctggagtgc aatggcgtga tcttggctca ctgcagcctt cgcctcccgg gttcaagtga     2640

ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgctccacc atgcccagct     2700

aattttgtat ttttagtaga aacggggttt caccatattg gtcaggctgg tctcgaactc     2760

cagacctcag gtgatccgcc cacctcggcc tcccaaactg ctgggattac aggcgtgagc     2820

caccgcgcct ggccagggac tatactcttt ttaaaataga catttgtggg gctcacacaa     2880

tatatgaaat agtaccctct aaaaaagaga aaaaaaaaat caggcggtca aacttagagc     2940

aacattgtct tattaaagca tagtttattt cactagaaaa aatttaatat caaggactat     3000

tacatacttc attactagga agttcttttt aaaatgacac ttaaaacaat cactgaaaac     3060

ttgatccaca tcacaccctg tttattttcc ttaaacatct tggaagccta agcttctgag     3120

aatcatgtgg caagtgtgat gggcagtaaa ataccagaga agatgtttag tagcaattaa     3180

aggctgtttg cacctttaag gaccagctgg gctgtagtga ttcctggggc cagagtggca     3240

ttatgttttt acaaaataat gacatatgtc acatgtttgc atgtttgttt gcttgttgaa     3300

tttttgaaca gccagttgac caatcataga aagtattact ttctttcata tggtttttgg     3360

ttcactggct taagaggttt ctcagaatat ctatggccac agcagcatac cagtttccat     3420

cctaatagga atgaaattaa ttttgtatct actgataaca gaatctgggt cacatgaaaa     3480

aaaatcattt tatccgtctt ttaagtatat gtttaaaata ataatttatg tgtctgcata     3540

ttgcagaaca gctctgagag caacagtttc ccattaactc tttctgacca atagtgctgg     3600

caccgttgct tcctctttgg gaagaggaaa gggtgtgtga acatggctaa caatcttcaa     3660

atacccaaat tgtgatagca taaataaagt atttatttta tgcctcagta tattattatt     3720

taatttttta ggtaatgcct atctcttggt ctattaagga aagaagcaat cagtagagaa     3780

ttcaggatag ttttgtttaa attcttgcag attacatgtt tttacagtgg cctgctattg     3840

aggaaaggta ttcttctata caacttgttt taacctttga gaacattgac agaaattatg     3900

caatggtttg ttgagatacg gacttgatgg tgctgtttaa tcagtttgct tccaaagtgg     3960

cctactcaag aggccctaag actggtagaa attaaaagga tttcaaaaac tttctattcc     4020

tttcttaaac ctaccagcaa actaggattg tgatagcaat gaatggtatg atgaagaaag     4080

tttgaccaaa tttgtttttt tgttgttgtt gttgttttga atttgaaatc attcttattc     4140

cctttaagaa tgtttatgta tgagtgtgaa gatgctagcg aacctatgct cagatattca     4200

tcgtaagtct cccttcacct gttacagagt ttcagatcgg tcactgatag tatgtatttc     4260

tttagtaaga atgtgttaaa attacaatga tcttttaaaa agatgatgca gttctgtatt     4320

tattgtgctg tgtctggtcc taagtggagc caattaaaca agtttcatat gtatttttcc     4380

agtgttgaat ctcacacact gtactttgaa aatttccttc catcctgaat aacgaataga     4440

agaggccata tatattgcct ccttatcctt gagatttcac tacctttatg ttaaaagttg     4500

tgtataattg ttaaaatctg tgaaagaata aaaagtggat ttaaattaaa aaaaaaaaaa     4560

aaaaaaa                                                               4567


<210>  30
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Asp Phe Thr Pro Cys Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Thr Val 
                165                 170                 175     


Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Thr Ser Asp Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Thr Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn 
    210                 215                 220                 


His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys 
225                 230                 235                 240 


Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys 
                245                 250                 255     


Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile 
            260                 265                 270         


Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu 
        275                 280                 285             


Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Val Glu Ser 
    290                 295                 300                 


Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val 
305                 310                 315                 320 


Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr 
                325                 330                 335     


Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser 
            340                 345                 350         


Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met 
        355                 360                 365             


Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser 
    370                 375                 380                 


Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg 
385                 390                 395                 400 


Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp 
                405                 410                 415     


Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe 
            420                 425                 430         


Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val 
        435                 440                 445             


Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr 
    450                 455                 460                 


Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val 
                485                 490                 495     


Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala 
            500                 505                 510         


Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr 
        515                 520                 525             


Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met 
    530                 535                 540                 


Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln 
545                 550                 555                 560 


Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Asp 
                565                 570                 575     


Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp 
            580                 585                 590         


Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met 
        595                 600                 605             


Gln Asn Ala Phe Arg Ser Leu Glu Asp 
    610                 615         


<210>  31
<211>  2461
<212>  DNA
<213>  Homo sapiens

<400>  31
gcgcgcagtt tcccgcatgc tcagtagctg aggtagggat gccatccttc tcaaaagact       60

tattgacagt gccaaagctc ggtactggac acaacgaggg acctgggtct acgataacgc      120

gcttttgctc ctcctgaagt gtctttggtc caacgttgtt ccagagtgta ccatggcttc      180

cagtaacact gtgttgatgc ggttggtagc ctccgcatat tctattgctc aaaaggcagg      240

aatgatagtc agacgtgtta ttgctgaagg agacctgggt attgtggaga agacctgtgc      300

aacagacctg cagaccaaag ctgaccgatt ggcacagatg agcatatgtt cttcattggc      360

ccggaaattc cccaaactca caattatagg ggaagaggat ctgccttctg aggaagtgga      420

tcaagagctg attgaagaca gtcagtggga agaaatactg aagcaaccat gcccatcgca      480

gtacagtgct attaaagaag aagatctcgt ggtctgggtt gatcctctgg atggaaccaa      540

ggaatatacc gaaggtcttc ttgacaatgt aacagttctt attggaattg cttatgaagg      600

aaaagccata gcaggagtta ttaaccagcc atattacaac tatgaggcag gaccagatgc      660

tgtgttgggg aggacaatct ggggagtttt aggtttaggc gcctttgggt ttcagctgaa      720

agaagtccct gctgggaaac acattatcac aactactcga tcccatagca acaagttggt      780

tactgactgt gttgctgcta tgaaccccga tgctgtgctg cgagtaggag gagcaggaaa      840

taagattatt cagctgattg aaggcaaagc ctctgcttat gtatttgcaa gtcctggttg      900

taagaagtgg gatacttgtg ctccagaagt tattttacat gctgtgggag gcaagttaac      960

cgatatccat gggaatgttc ttcagtacca caaggatgtg aagcatatga actctgcagg     1020

agtcctggcc acactgagga attatgacta ctatgcaagc cgagttccag aatctattaa     1080

aaatgcactt gttccttaaa ggaaagtttc atttggccgg gcgcggtggc tcatgcctgt     1140

aatcccagca ctttgggagg ccgaggcagg tggatcactt gagctcagga gtttgagacc     1200

agcctgggca atatcgtgag accccatctc tacaaaaata caaattaact gggcatcctg     1260

tcatgcgcct gtcatcccag ctacttgaga ggctgaagca gaagaatctc ttgagcccgg     1320

aaggcagagg ttgcagtgag ctgagatcgt gccactgcac tccagcctga gtgacaggag     1380

ttaagccctg tctcagaaaa aaaaaaaaca aaaacccaaa aagtacttaa agtttcattt     1440

acttagctag gagaaagact tggttctcaa aataatacat tttaagatta attgggtaga     1500

attagagttc cacctttatt cattgttgag cagtgattta tatttagtta ttatatttag     1560

gaatagaaaa tagaattaaa taatttaact tgattaatca accagaccaa ttttgacgtc     1620

tggagaactt ataaactcaa tatgttatat ttgttttcct gtatttaggt ggagaaatga     1680

gaaaaagctt tagttccaat tgacagttca ggtcaatgtt caatgaacat tcctatcttc     1740

taaaccagat ttctcttttt ttttcctgag acggagtctc gctctgtagc ctaggctaga     1800

atgtagtggc gtgatctcgg ctcactgcaa gctccgcctc ccgggttcat gccattctcc     1860

tgcctcagcc tcccgagtag ctgggactgc aggcaccgcc accacgcctg gctaattttt     1920

tgtattttta gtagagaagg tgtttcaccg tgttagccag gatggtcttg atctcctgac     1980

atcgtgatct gtctgcctcg gactcccaaa gtgctgggat tacaggtgtg agccaccgca     2040

cctggcctaa accagatttc tttagggcac aattttttct ggaatctcac tcttgttttt     2100

cacagtaatt ttaaaaacgt ttctactcca attaagaata tatatgatgt tattatatat     2160

gcttatgaaa cagatttatg agaaaagttt tttttaaata aattatttaa tcctagctct     2220

ttgttattca ccagcttttt aaaaaagtgt ttgaaaatta tacattctcg actttgggga     2280

ttagtttatt cttgtggcat cattataagg cttaattgtg gaaagctaag tacttgcttc     2340

tattccttcc aatgagagat tataacataa actattaaaa ttattctgct aatataccta     2400

gatttttatt tttaggtctc tgtccattgc ttttaattaa aattatctgt tttcaaatca     2460

a                                                                     2461


<210>  32
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


Leu Leu Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys 
    130                 135                 140                 


Ala Ile Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly 
145                 150                 155                 160 


Pro Asp Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly 
                165                 170                 175     


Ala Phe Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile 
            180                 185                 190         


Thr Thr Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala 
        195                 200                 205             


Ala Met Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys 
    210                 215                 220                 


Ile Ile Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser 
225                 230                 235                 240 


Pro Gly Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His 
                245                 250                 255     


Ala Val Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr 
            260                 265                 270         


His Lys Asp Val Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu 
        275                 280                 285             


Arg Asn Tyr Asp Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn 
    290                 295                 300                 


Ala Leu Val Pro 
305             


<210>  33
<211>  2403
<212>  DNA
<213>  Homo sapiens

<400>  33
ctgactaacg tgggcggagc tctagctcgc gtatcctgag gaggcggggt tggcctaggc       60

gaagatccgg actctgggtg ttttgctacc gtgaccgttt agaacagaaa ctgttcatac      120

ttggtgcgct gtggactctt gtgataatta accaagagta gctctatttg tccaacctca      180

cacctaaaga agaaagaaaa tggcttgtgc tgagttttct tttcatgtac caagtcttga      240

agagcttgct ggagttatgc agaaggggtt aaaagataac tttgctgatg tccaggtctc      300

tgtagttgat tgccctgatt tgactaagga accctttacc tttcctgtaa aaggcatctg      360

tgggaaaact agaattgcag aagttggagg tgtgccttac ttattgcctc ttgtaaacca      420

aaaaaaagtt tatgatctga ataaaattgc aaaagaaatc aagctgcctg gagcctttat      480

tcttggagca ggagcaggtc catttcagac tctcgggttc aattctgagt ttatgccagt      540

tattcagaca gaaagtgaac acaagcctcc tgtaaatgga agttactttg cccatgtgaa      600

ccctgcagat ggagggtgcc tactggagaa atacagtgag aaatgtcatg attttcagtg      660

tgcattactg gctaatcttt ttgccagtga aggccaacct ggcaagcctg cagaattttc      720

ttcctgcccc ttgaactctg atgaagaagt gaataaatgg ttgcattttt atgaaatgaa      780

agctcctttg gtttgtctac cagtttttgt ctccagagac ccagggtttg atttgcgact      840

ggagcacact cattttttta gtcgtcatgg agaaggtgga cactaccatt atgacactac      900

tccagatata gtggaatatc ttggatactt cttacctgca gagtttctct atcgcattga      960

tcaaccaaaa gagacgcatt caattgggcg agattaaatc agctgatact tatttagaaa     1020

aagaaataat taaggttaat taattgattg acttattaat taatactgat ataaaaccaa     1080

tagaaatgat cccacaggcc aggcacaatg gctcatgcct ataatcccag cactttggga     1140

ggctgaggca ggaagcacac tggagcccag gagtttgaga ccagcttggg caacatagca     1200

agaccctgtc tattttttta aaaaagtaaa aaatagaaat tatctcacta cttaaatccc     1260

atttttttca cttcatatga aagaacatat tgatagtata ttctatatta tttcatagat     1320

ctgtctgaaa gagattggga acaaaaatat ctaattgaga tattctttaa ttttttacat     1380

agcagcttta ttttttttat tctgtagtat cagcgaaatc agtcatgttt ataccttgaa     1440

tataaatatc aggaatcatg caattatttc tactatgtat ttagtagtat cttatatttg     1500

tataacatta ttacattttg caaattagta tcacaactgc taagtagatg tttctgagta     1560

ttagaaaaat cagtgttatt acctgcagga tattaaaaaa catttgaaaa agagaaaaag     1620

aaaaatcagt gtttagaaat gttgatagtt attgaatctt tgaattgaat tttaaaaatc     1680

cattctagta atcagagtat acttttttta tagaacaagg tggcaggtgg ggagcccttt     1740

acccttctgg tgaagttaaa ccatagaagt ttacaatttg cctttcacaa acattagcag     1800

tccgggcatg gtggctgaag cctgtgatcc cagcatgttg ggaggccgag tgggaggatt     1860

gcctgagcct aggagtttaa accagcctgg gcaccatggt gagaccccat ctctattatt     1920

taaaatgttt cttaaataaa aaaaacacaa acattagcaa ctagttggct agccataatt     1980

cctcccttgt ttcgattgcc agttagaagc aatttttatt tcactggtta tttgcaagag     2040

aaggggtaaa aaaacagcat cagagtgcaa cactgaagtg agcttacttt aatttgtaag     2100

tgaagctgtt gctgaacgtg accactatcg ttgctgaaat ataaaattat actcactgat     2160

tgtaatggtt gaaattttcc tgaataatca ttagccaaag atcaactctc taatggtgct     2220

aatggcaatc tagctaatgt gcaaatttag gaagtcttca gtactaagta cataattttc     2280

aaataatatt ttttaattgt ctactttgga tgttagctat gtcttgtgag tataaattcc     2340

aattttaagc actattttga tgcaaaaaaa tgaataaaaa atttaattta aaaaaaaaaa     2400

aaa                                                                   2403


<210>  34
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Cys Ala Glu Phe Ser Phe His Val Pro Ser Leu Glu Glu Leu 
1               5                   10                  15      


Ala Gly Val Met Gln Lys Gly Leu Lys Asp Asn Phe Ala Asp Val Gln 
            20                  25                  30          


Val Ser Val Val Asp Cys Pro Asp Leu Thr Lys Glu Pro Phe Thr Phe 
        35                  40                  45              


Pro Val Lys Gly Ile Cys Gly Lys Thr Arg Ile Ala Glu Val Gly Gly 
    50                  55                  60                  


Val Pro Tyr Leu Leu Pro Leu Val Asn Gln Lys Lys Val Tyr Asp Leu 
65                  70                  75                  80  


Asn Lys Ile Ala Lys Glu Ile Lys Leu Pro Gly Ala Phe Ile Leu Gly 
                85                  90                  95      


Ala Gly Ala Gly Pro Phe Gln Thr Leu Gly Phe Asn Ser Glu Phe Met 
            100                 105                 110         


Pro Val Ile Gln Thr Glu Ser Glu His Lys Pro Pro Val Asn Gly Ser 
        115                 120                 125             


Tyr Phe Ala His Val Asn Pro Ala Asp Gly Gly Cys Leu Leu Glu Lys 
    130                 135                 140                 


Tyr Ser Glu Lys Cys His Asp Phe Gln Cys Ala Leu Leu Ala Asn Leu 
145                 150                 155                 160 


Phe Ala Ser Glu Gly Gln Pro Gly Lys Pro Ala Glu Phe Ser Ser Cys 
                165                 170                 175     


Pro Leu Asn Ser Asp Glu Glu Val Asn Lys Trp Leu His Phe Tyr Glu 
            180                 185                 190         


Met Lys Ala Pro Leu Val Cys Leu Pro Val Phe Val Ser Arg Asp Pro 
        195                 200                 205             


Gly Phe Asp Leu Arg Leu Glu His Thr His Phe Phe Ser Arg His Gly 
    210                 215                 220                 


Glu Gly Gly His Tyr His Tyr Asp Thr Thr Pro Asp Ile Val Glu Tyr 
225                 230                 235                 240 


Leu Gly Tyr Phe Leu Pro Ala Glu Phe Leu Tyr Arg Ile Asp Gln Pro 
                245                 250                 255     


Lys Glu Thr His Ser Ile Gly Arg Asp 
            260                 265 


<210>  35
<211>  1631
<212>  DNA
<213>  Homo sapiens

<400>  35
ggagacacag ggccgctcag aggccgccgc aatgctcccc tctttgcagg agtcgatgga       60

tggagatgaa aaggaactag agagcagcga agagggaggc tcagccgagg agcggagact      120

cgagccgccg tccagcagcc actactgtct ttacagctat cgcggaagca gattggcaca      180

gcaacgaggg gacagtgagg acggaagccc aagtggcaca aatgcagaaa ctccctctgg      240

tgatgatttc agcctctcct tggcagatac taatctacca tccgaagtgg agccagagct      300

gcgcagtttc attgctaagc gtctttcaag aggtgcagtc tttgaagggc tgggtaatgt      360

tgcatctgtg gagctaaaaa ttccaggtta ccgagttggt tgttattact gccttttcca      420

aaatgaaaaa ctgcttcctg aaacagtaac gatagactct gaacgtaacc cttcagaata      480

tgtggtctgt tttttaggag ggtctgaaaa aggacttgag cttttcaggc ttgaattgga      540

caagtacatt caagggctga aaaataacat gaattgtgag gcaaggggcc tggagagtca      600

cataaaatcc tatctgagca gctggtttga ggatgttgta tgcccaatcc aaagggttgt      660

tcttctcttt caggaaaagc ttacctttct gctacatgct gctttgagtt acactcctgt      720

tgaagttaaa gaatcagatg aaaaaacaaa gagagacatt aacaggtttc tgagtgtggc      780

cagtcttcaa ggacttattc atgaaggcac catgacttct ttgtgcatgg ccatgacaga      840

ggagcagcat aagtctgtgg tcatcgattg cagcagctcc cagcctcagt tctgcaatgc      900

aggaagtaac cggttttgtg aggattggat gcaagctttt ttaaatggtg ccaaaggagg      960

taaccctttt cttttccgac aagtactgga gaactttaaa ctaaaggcca tacaagacac     1020

aaacaatttg aagagattta tccgacaggc agaaatgaat cattatgctt tgtttaaatg     1080

ttacatgttc ctaaagaact gtggtagtgg agatatactt ttgaagattg ttaaagtgga     1140

acatgaagaa atgcctgaag ccaaaaatgt gatagctgtc cttgaagaat tcatgaaaga     1200

agctcttgac caaagttttt gatcatatgt tttgagataa ttgtatgatc aagttgtata     1260

tttaagtctt agtgtttgaa attgcagtta taattgttca taggattgct atttaagatg     1320

atttgaaact caatccagat tttctttttg tattttacca atttaactta aataaaaatc     1380

tgaagaacat cttcactgag tcctagatag ataatgtatg tgagagttgt gaaattttag     1440

tgtctcactg gccccataaa ttccacgctt caggaagttg ttgcttaaaa aatttcagag     1500

atgattttgt ttgtggcttt tctcaggaaa agcctgagtt tgctgcagta tttagcaact     1560

tttcttctca gaaaaaccat aatacttcct tttcagtgga ctgtagcttc ttaaaaaaaa     1620

aaaaaaaaaa a                                                          1631


<210>  36
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu 
1               5                   10                  15      


Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro 
            20                  25                  30          


Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu 
        35                  40                  45              


Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn 
    50                  55                  60                  


Ala Glu Thr Pro Ser Gly Asp Asp Phe Ser Leu Ser Leu Ala Asp Thr 
65                  70                  75                  80  


Asn Leu Pro Ser Glu Val Glu Pro Glu Leu Arg Ser Phe Ile Ala Lys 
                85                  90                  95      


Arg Leu Ser Arg Gly Ala Val Phe Glu Gly Leu Gly Asn Val Ala Ser 
            100                 105                 110         


Val Glu Leu Lys Ile Pro Gly Tyr Arg Val Gly Cys Tyr Tyr Cys Leu 
        115                 120                 125             


Phe Gln Asn Glu Lys Leu Leu Pro Glu Thr Val Thr Ile Asp Ser Glu 
    130                 135                 140                 


Arg Asn Pro Ser Glu Tyr Val Val Cys Phe Leu Gly Gly Ser Glu Lys 
145                 150                 155                 160 


Gly Leu Glu Leu Phe Arg Leu Glu Leu Asp Lys Tyr Ile Gln Gly Leu 
                165                 170                 175     


Lys Asn Asn Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys 
            180                 185                 190         


Ser Tyr Leu Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg 
        195                 200                 205             


Val Val Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala 
    210                 215                 220                 


Leu Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys 
225                 230                 235                 240 


Arg Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile 
                245                 250                 255     


His Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln 
            260                 265                 270         


His Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys 
        275                 280                 285             


Asn Ala Gly Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu 
    290                 295                 300                 


Asn Gly Ala Lys Gly Gly Asn Pro Phe Leu Phe Arg Gln Val Leu Glu 
305                 310                 315                 320 


Asn Phe Lys Leu Lys Ala Ile Gln Asp Thr Asn Asn Leu Lys Arg Phe 
                325                 330                 335     


Ile Arg Gln Ala Glu Met Asn His Tyr Ala Leu Phe Lys Cys Tyr Met 
            340                 345                 350         


Phe Leu Lys Asn Cys Gly Ser Gly Asp Ile Leu Leu Lys Ile Val Lys 
        355                 360                 365             


Val Glu His Glu Glu Met Pro Glu Ala Lys Asn Val Ile Ala Val Leu 
    370                 375                 380                 


Glu Glu Phe Met Lys Glu Ala Leu Asp Gln Ser Phe 
385                 390                 395     


<210>  37
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  37
gtcagctgcg tttccgcggt cgcgggtgag tgtgcccggg ctagcggcct gggttgggct       60

ttgtagctgc tccgcaggcc cagcccgggc cgcgctcgca gagtcctagg cggtgcgcgg      120

cctcctgcct cctccctcct cggcggtcgc ggcccgccgg cctccgcggt gcctgccttc      180

gctctcaggt tgaggagctc aagcttggga aaatggtgtg cattccttgt atcgtcattc      240

cagttctgct ctggatctac aaaaaattcc tggagccata tatataccct ctggtttccc      300

ccttcgttag tcgtatatgg cctaagaaag caatacaaga atccaatgat acaaacaaag      360

gcaaagtaaa ctttaagggt gcagacatga atggattacc aacaaaagga ccaacagaaa      420

tctgtgataa aaagaaagac taaagaaatt ttcctaaagg accccatcat ttaaaaaatg      480

gacctgataa tatgaagcat cttccttgta attgtctctg acctttttat ctgagaccgg      540

aattcaggat aggagtctag atatttacct gatactaatc aggaaatata tgatatccgt      600

atttaaaatg tagttagtta tatttaatga cctcattcct aagttccttt ttcgttaatg      660

tagctttcat ttctgttatt gctgtttgaa taatatgatt aaatagaagg tttgtgccag      720

tagacattat gttactaaat cagcacttta aaatctttgg ttctctaatt catatgaatt      780

tgctgtttgc tctaatttct ttgggctctt ctaatttgag tggagtacaa ttttgttgtg      840

aaacagtcca gtgaaactgt gcagggaaat gaaggtagaa ttttgggagg taataatgat      900

gtgaaacata aagatttaat aattactgtc caacacagtg gagcagcttg tccacaaata      960

tagtaattac tatttattgc tctaaggaag attaaaaaaa gatagggaaa agggggaaac     1020

ttctttgaaa aatgaaacat ctgttacatt aatgtctaat tataaaattt taatccttac     1080

tgcatttctt ctgttcctac aaatgtatta aacattcagt ttaactggaa aaaaaaaaaa     1140

aaa                                                                   1143


<210>  38
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Cys Ile Pro Cys Ile Val Ile Pro Val Leu Leu Trp Ile Tyr 
1               5                   10                  15      


Lys Lys Phe Leu Glu Pro Tyr Ile Tyr Pro Leu Val Ser Pro Phe Val 
            20                  25                  30          


Ser Arg Ile Trp Pro Lys Lys Ala Ile Gln Glu Ser Asn Asp Thr Asn 
        35                  40                  45              


Lys Gly Lys Val Asn Phe Lys Gly Ala Asp Met Asn Gly Leu Pro Thr 
    50                  55                  60                  


Lys Gly Pro Thr Glu Ile Cys Asp Lys Lys Lys Asp 
65                  70                  75      


<210>  39
<211>  5316
<212>  DNA
<213>  Homo sapiens

<400>  39
agtggcaggg tgggggccag gcagcacaga tgaagcattt acctatctag gtaagtcagg       60

aggagctcaa aaggagaaga aaacagtagg aggcagggga agcagcctct gtctccatct      120

ctgccctttg aaacaaaagg gtatttcttt tctctcttca gcccccaacc cagtggagag      180

tgatagcagc tacgacttcc tgtccactga agagaaggag tgtctgctct tcctggagga      240

gaccattggc tcactggaca cggaggctga cagcggactg tccactgacg agtctgagcc      300

agccacaact cccagaggtt tccgagcact gcccataacc caacccactc cccggggagg      360

tccagaggag accatcactc agcaaggacg aacgccaagg acagtaactg agtccagctc      420

atcccaccct cctgagcccc agggcctagg cctcaggtct ggctcctaca gcctccctag      480

gaatatccac attgccagaa gccagaactt caggaaaagc accacccagg ctagcagtca      540

caaccctgga gaaccgggga ggcttgcgcc agagcctgag aaagaacagg tcagccagag      600

cagccaaccc aggcaggcac ctgccagccc ccaggaggct gcccttgact tggacgtggt      660

gctcatccct ccgccagaag ctttccggga cacccagcca gagcagtgta gggaagccag      720

cctgcccgag gggccaggac agcagggcca cacaccccag ctccacacac catccagctc      780

ccaggaaaga gagcagactc cttcagaagc catgtcccaa aaagccaagg aaacagtctc      840

aaccaggtac acacaacccc agcctcctcc tgcagggttg cctcagaatg caagagctga      900

agatgctccc ctctcatcag gggaggaccc aaacagccga ctagctcccc tcacaacccc      960

taagccccgg aagctgccac ctaatattgt tctgaagagc agccgaagca gtttccacag     1020

tgacccccag cactggctgt cccgccacac tgaggctgcc cctggagatt ctggcctgat     1080

ctcctgttca ctgcaagagc agagaaaagc acgtaaagaa gctctagaga agctggggct     1140

accccaggat caagatgagc ctggactcca cttaagtaag cccaccagct ccatcagacc     1200

caaggagaca cgggcccagc atctgtcccc agctccaggt ctggctcagc ctgcagctcc     1260

agcccaggcc tcagcagcta ttcctgctgc tgggaaggct ctggctcaag ctccggctcc     1320

agctccaggt ccagctcagg gacctttgcc aatgaagtct ccagctccag gcaatgttgc     1380

agctagcaaa tctatgccaa tttctatccc taaggcccca agggcaaaca gtgccctgac     1440

tccaccgaag ccagagtcag ggctgactct ccaggagagc aacacccctg gcctgagaca     1500

gatgaacttc aagtccaaca ctctggagcg ctcaggcgtg ggactgagca gctacctttc     1560

aactgagaaa gatgccagcc ccaaaaccag cacttctctg ggaaagggct ccttcttgga     1620

caagatctcg cccagtgtct tacgtaattc tcggccccgc ccggcctccc tgggcacggg     1680

gaaagatttt gcaggtatcc aggtaggcaa gctggctgac ctggagcagg agcagagctc     1740

caagcgcctg tcctaccaag gacagagccg tgacaagctt cctcgccccc cctgtgtcag     1800

tgtcaagatc tccccaaagg gtgtccccaa tgaacacaga agggaggccc tgaagaagct     1860

gggactgttg aaggagtaga ctctgcgacc agtacagacc ctgtcctggc tgaacaagaa     1920

gagacacatg ctccacttgg gagcctttgc caccacgcaa ctcagggctc aagatgaatg     1980

ggagggagag atttgagtcc aagcatacat ttatattcag tgttgtgcca ttgagttccc     2040

atgtggatca ttctgaaggt gatctccaca agagggtgtg tgtgtgtgtg tttggtgtgt     2100

gtgtggaggg ggggccgctg gatacatcac tgaagctatt gatataacac aatgagtcac     2160

tgttcagaat tttgctcttg ttagatgttt tcttacattg ggtagagtcc agcctagtga     2220

gagctgagtg aaggggctgg ccatgcctga gacaaaaagt caaatgagac aatggacgtg     2280

tcaatgactt gaaaaaaagt cacatccagc aaatgcaggg tcacatgaaa tatgggcctc     2340

ctggaatccc tacagtggat ggagactggc tcataccttg ccagatccct ctctcagttc     2400

cagccttctg gacaaggcct gggctaagag gagctgattc gttatctctt cacccactgc     2460

cctctcagta tcaccagtcc caaagacagg atacgtccct gtaacccaat ctctcggttg     2520

attgatagca gaacagctct tgttggtctg agaaggcagg ataagtgacc acatatttat     2580

gccactacct ccaccaggga gagtccttct ccacaggctt gataaattca atcaccaact     2640

gtgctgtcgt ccctgactct gctactcccg ttcttcctgc tttcctgctc cgtatctcag     2700

tctgcactga ccccagggct gggctgacat caagatggga gcccagccca cgggctttat     2760

aaacacccaa gaaccgtttc agatcttctc tgtgctgatg caggtagttt taaatttttc     2820

tcagttccag tgatagaaaa cccacacaat acatcctctg ccagtcttaa tagaatatca     2880

gaggtaagag gggcctcaga gaagctctga cgcagtgctg ctggggaagg gaagtgacta     2940

accccgggtc agcctgccat ttagggaaag agctgaggtt cttacccttg ttgcatgctg     3000

ccacctctcc ttagccagtg ctcttgtaca tccacacagc accctaagga gccatagtca     3060

ccatcaaaga ctcaacccta aggcccttca agatctcaaa gtgccttctg aagcatcaga     3120

gattaaatat tgttcaaact aatagttatt gctgtggctt ttaattttat ctttggaaga     3180

tagctatatg gtaactcatc attaaccaga acacctctcc cctcaaattc cgtgaccaag     3240

ttgtgcagct tgagcaaatg ccgaaagagg gtattatggg tgggtggtgt gggcttgcaa     3300

atacaagctt ggaggtgaga catggccaga catgactcct gcttcccctt aggaagtaaa     3360

tcttacttat ggttgtgaac tgcttggagt ccaggatgcc cagatgtgag gggcagatga     3420

agggaatgtt gctggaaagg tgccttttaa ggctgctgag aatttctgga ctgtgtcctg     3480

atggacgcag caccatcaaa gcccagaatt tctgaaaacg gtgacaaggt taacataagg     3540

acaacaaata ctccaccctg tcatggtatg tgaggtgtgg gtgtggcggt ttctgtgtac     3600

gtttgctcat acacgcacat ccaaaagcct gtgcctcatt cctggccatg ggtgaggact     3660

tggtctgtca cggctgatga ggactcccac aaccggccaa gttatgtctt attatacacc     3720

cccagaaaga gagaaagctg ccttctggag gactgattcc acatgctata ttcagctgag     3780

ttgatttctg tgtctatttc aacccataac ctgaagaatg atcaccttat tccttattca     3840

ttaattttct tgattaatag ggaaacttgg gaatagctat aaagtaaaac ttgggtggaa     3900

cctggggccc tggcatcaca caagtgtgat taggatggtc aaggtcatca ggagtacagc     3960

ctattatatt cccacatcct gagaaaggtc atttctccca cacacgacaa agtcacagac     4020

atcctgcacc tgccactagg catcctcatc ctactgacat gcccatttct ccagttttct     4080

taatctgaga ctcccttccc ttgtttttta aagataccgt gcttctccac atcctcatcc     4140

ttcaaggagc atattttgct cttaggatgg tctttgggat tcaagaatag aataataaat     4200

ccaaacttgg tcattcccat tttgaagaga tgcaagaggg cccagtgagg acatccgcct     4260

ccctgaaagt ggtgctagac agagctgagg tcattgtatc tgtgtatcca cataggattt     4320

ctcttaattc agcttgaatt gatggggagg gaggtaagag tagggtcaga gttactcatc     4380

ccttttcaaa gaattgtggg tggaagtttg taaaggccat tcatttgatt ttcaaaatca     4440

aagcgacagc tctacttcca cttggcctta gatctctgct ataccctgcc atagccttga     4500

tgccactggg cacaagccac ctgccaaata caggagtggc ctctcccagc ctggcatgat     4560

aggggggtct gtgccctcag atgtgttgac agctgctctt ctgaattgcc acacctgtgc     4620

tacacttgga attctgtgct ctgactctgc agggtaggac cacgtgccat ctcacacaga     4680

ggtcaaccga tgagcccact cactcgtaca tgccttcttc cacagtggga agcatgatct     4740

ggcaggggcc gccctgtagg ctggggatgg gctgctgtgt gaatgttgac gttcgtttca     4800

tggagaaagg ggaggtgaaa gattgaagag caggttcctg tcaatgttct gagttcgagc     4860

tggaggtgta gattgaatag tctacatggt ctgtgagtgt gtgagatgaa cccttccatc     4920

ctttgacacc tggttgtatg tgtaggctaa gaaggaagga ccctcctgtc agtgtgcaaa     4980

gctgtaatct catggactag aggagagggg gccaagggga tggacaggag aagtcatgca     5040

gaatctaagc aggaatgcag atagaacaca tctaggctct tttccccagg agagtgatga     5100

tggagcatat agatctggct caaattcagc ctccatcact taccagtcag gaaccctggc     5160

gatatcactt taactttctg aacctcagag tcttcaccta taagacgggg aaaataatac     5220

caccctttca agattgttga gataaataag tgatataaaa catgtaaagc ttagttctgg     5280

ccacagtgta gctactcaat aaatgataat actacc                               5316


<210>  40
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Gln Lys Ala Lys Glu Thr Val Ser Thr Arg Tyr Thr Gln Pro 
1               5                   10                  15      


Gln Pro Pro Pro Ala Gly Leu Pro Gln Asn Ala Arg Ala Glu Asp Ala 
            20                  25                  30          


Pro Leu Ser Ser Gly Glu Asp Pro Asn Ser Arg Leu Ala Pro Leu Thr 
        35                  40                  45              


Thr Pro Lys Pro Arg Lys Leu Pro Pro Asn Ile Val Leu Lys Ser Ser 
    50                  55                  60                  


Arg Ser Ser Phe His Ser Asp Pro Gln His Trp Leu Ser Arg His Thr 
65                  70                  75                  80  


Glu Ala Ala Pro Gly Asp Ser Gly Leu Ile Ser Cys Ser Leu Gln Glu 
                85                  90                  95      


Gln Arg Lys Ala Arg Lys Glu Ala Leu Glu Lys Leu Gly Leu Pro Gln 
            100                 105                 110         


Asp Gln Asp Glu Pro Gly Leu His Leu Ser Lys Pro Thr Ser Ser Ile 
        115                 120                 125             


Arg Pro Lys Glu Thr Arg Ala Gln His Leu Ser Pro Ala Pro Gly Leu 
    130                 135                 140                 


Ala Gln Pro Ala Ala Pro Ala Gln Ala Ser Ala Ala Ile Pro Ala Ala 
145                 150                 155                 160 


Gly Lys Ala Leu Ala Gln Ala Pro Ala Pro Ala Pro Gly Pro Ala Gln 
                165                 170                 175     


Gly Pro Leu Pro Met Lys Ser Pro Ala Pro Gly Asn Val Ala Ala Ser 
            180                 185                 190         


Lys Ser Met Pro Ile Ser Ile Pro Lys Ala Pro Arg Ala Asn Ser Ala 
        195                 200                 205             


Leu Thr Pro Pro Lys Pro Glu Ser Gly Leu Thr Leu Gln Glu Ser Asn 
    210                 215                 220                 


Thr Pro Gly Leu Arg Gln Met Asn Phe Lys Ser Asn Thr Leu Glu Arg 
225                 230                 235                 240 


Ser Gly Val Gly Leu Ser Ser Tyr Leu Ser Thr Glu Lys Asp Ala Ser 
                245                 250                 255     


Pro Lys Thr Ser Thr Ser Leu Gly Lys Gly Ser Phe Leu Asp Lys Ile 
            260                 265                 270         


Ser Pro Ser Val Leu Arg Asn Ser Arg Pro Arg Pro Ala Ser Leu Gly 
        275                 280                 285             


Thr Gly Lys Asp Phe Ala Gly Ile Gln Val Gly Lys Leu Ala Asp Leu 
    290                 295                 300                 


Glu Gln Glu Gln Ser Ser Lys Arg Leu Ser Tyr Gln Gly Gln Ser Arg 
305                 310                 315                 320 


Asp Lys Leu Pro Arg Pro Pro Cys Val Ser Val Lys Ile Ser Pro Lys 
                325                 330                 335     


Gly Val Pro Asn Glu His Arg Arg Glu Ala Leu Lys Lys Leu Gly Leu 
            340                 345                 350         


Leu Lys Glu 
        355 


<210>  41
<211>  5502
<212>  DNA
<213>  Homo sapiens

<400>  41
agtggcaggg tgggggccag gcagcacaga tgaagcattt acctatctag gtaagtcagg       60

aggagctcaa aaggagaaga aaacagtagg aggcagggga agcagcctct gtctccatct      120

ctgccctttg aaacaaaagg gtatttcttt tctctcttca gcccccaacc cagtggaggc      180

ccggcttggg acattgttca cttcccctcg cttcccctct agaagccccc tttgccatcc      240

ctgcaccttg tttcgggtga tgcccgagag ggagctgtgg ccagcgggga ctggctcaga      300

acccgtgacc cgtgtcggca gctgtgacag catgatgagc agcacctcca cccgctctgg      360

atctagtgat agcagctacg acttcctgtc cactgaagag aaggagtgtc tgctcttcct      420

ggaggagacc attggctcac tggacacgga ggctgacagc ggactgtcca ctgacgagtc      480

tgagccagcc acaactccca gaggtttccg agcactgccc ataacccaac ccactccccg      540

gggaggtcca gaggagacca tcactcagca aggacgaacg ccaaggacag taactgagtc      600

cagctcatcc caccctcctg agccccaggg cctaggcctc aggtctggct cctacagcct      660

ccctaggaat atccacattg ccagaagcca gaacttcagg aaaagcacca cccaggctag      720

cagtcacaac cctggagaac cggggaggct tgcgccagag cctgagaaag aacaggtcag      780

ccagagcagc caacccaggc aggcacctgc cagcccccag gaggctgccc ttgacttgga      840

cgtggtgctc atccctccgc cagaagcttt ccgggacacc cagccagagc agtgtaggga      900

agccagcctg cccgaggggc caggacagca gggccacaca ccccagctcc acacaccatc      960

cagctcccag gaaagagagc agactccttc agaagccatg tcccaaaaag ccaaggaaac     1020

agtctcaacc aggtacacac aaccccagcc tcctcctgca gggttgcctc agaatgcaag     1080

agctgaagat gctcccctct catcagggga ggacccaaac agccgactag ctcccctcac     1140

aacccctaag ccccggaagc tgccacctaa tattgttctg aagagcagcc gaagcagttt     1200

ccacagtgac ccccagcact ggctgtcccg ccacactgag gctgcccctg gagattctgg     1260

cctgatctcc tgttcactgc aagagcagag aaaagcacgt aaagaagctc tagagaagct     1320

ggggctaccc caggatcaag atgagcctgg actccactta agtaagccca ccagctccat     1380

cagacccaag gagacacggg cccagcatct gtccccagct ccaggtctgg ctcagcctgc     1440

agctccagcc caggcctcag cagctattcc tgctgctggg aaggctctgg ctcaagctcc     1500

ggctccagct ccaggtccag ctcagggacc tttgccaatg aagtctccag ctccaggcaa     1560

tgttgcagct agcaaatcta tgccaatttc tatccctaag gccccaaggg caaacagtgc     1620

cctgactcca ccgaagccag agtcagggct gactctccag gagagcaaca cccctggcct     1680

gagacagatg aacttcaagt ccaacactct ggagcgctca ggcgtgggac tgagcagcta     1740

cctttcaact gagaaagatg ccagccccaa aaccagcact tctctgggaa agggctcctt     1800

cttggacaag atctcgccca gtgtcttacg taattctcgg ccccgcccgg cctccctggg     1860

cacggggaaa gattttgcag gtatccaggt aggcaagctg gctgacctgg agcaggagca     1920

gagctccaag cgcctgtcct accaaggaca gagccgtgac aagcttcctc gccccccctg     1980

tgtcagtgtc aagatctccc caaagggtgt ccccaatgaa cacagaaggg aggccctgaa     2040

gaagctggga ctgttgaagg agtagactct gcgaccagta cagaccctgt cctggctgaa     2100

caagaagaga cacatgctcc acttgggagc ctttgccacc acgcaactca gggctcaaga     2160

tgaatgggag ggagagattt gagtccaagc atacatttat attcagtgtt gtgccattga     2220

gttcccatgt ggatcattct gaaggtgatc tccacaagag ggtgtgtgtg tgtgtgtttg     2280

gtgtgtgtgt ggaggggggg ccgctggata catcactgaa gctattgata taacacaatg     2340

agtcactgtt cagaattttg ctcttgttag atgttttctt acattgggta gagtccagcc     2400

tagtgagagc tgagtgaagg ggctggccat gcctgagaca aaaagtcaaa tgagacaatg     2460

gacgtgtcaa tgacttgaaa aaaagtcaca tccagcaaat gcagggtcac atgaaatatg     2520

ggcctcctgg aatccctaca gtggatggag actggctcat accttgccag atccctctct     2580

cagttccagc cttctggaca aggcctgggc taagaggagc tgattcgtta tctcttcacc     2640

cactgccctc tcagtatcac cagtcccaaa gacaggatac gtccctgtaa cccaatctct     2700

cggttgattg atagcagaac agctcttgtt ggtctgagaa ggcaggataa gtgaccacat     2760

atttatgcca ctacctccac cagggagagt ccttctccac aggcttgata aattcaatca     2820

ccaactgtgc tgtcgtccct gactctgcta ctcccgttct tcctgctttc ctgctccgta     2880

tctcagtctg cactgacccc agggctgggc tgacatcaag atgggagccc agcccacggg     2940

ctttataaac acccaagaac cgtttcagat cttctctgtg ctgatgcagg tagttttaaa     3000

tttttctcag ttccagtgat agaaaaccca cacaatacat cctctgccag tcttaataga     3060

atatcagagg taagaggggc ctcagagaag ctctgacgca gtgctgctgg ggaagggaag     3120

tgactaaccc cgggtcagcc tgccatttag ggaaagagct gaggttctta cccttgttgc     3180

atgctgccac ctctccttag ccagtgctct tgtacatcca cacagcaccc taaggagcca     3240

tagtcaccat caaagactca accctaaggc ccttcaagat ctcaaagtgc cttctgaagc     3300

atcagagatt aaatattgtt caaactaata gttattgctg tggcttttaa ttttatcttt     3360

ggaagatagc tatatggtaa ctcatcatta accagaacac ctctcccctc aaattccgtg     3420

accaagttgt gcagcttgag caaatgccga aagagggtat tatgggtggg tggtgtgggc     3480

ttgcaaatac aagcttggag gtgagacatg gccagacatg actcctgctt ccccttagga     3540

agtaaatctt acttatggtt gtgaactgct tggagtccag gatgcccaga tgtgaggggc     3600

agatgaaggg aatgttgctg gaaaggtgcc ttttaaggct gctgagaatt tctggactgt     3660

gtcctgatgg acgcagcacc atcaaagccc agaatttctg aaaacggtga caaggttaac     3720

ataaggacaa caaatactcc accctgtcat ggtatgtgag gtgtgggtgt ggcggtttct     3780

gtgtacgttt gctcatacac gcacatccaa aagcctgtgc ctcattcctg gccatgggtg     3840

aggacttggt ctgtcacggc tgatgaggac tcccacaacc ggccaagtta tgtcttatta     3900

tacaccccca gaaagagaga aagctgcctt ctggaggact gattccacat gctatattca     3960

gctgagttga tttctgtgtc tatttcaacc cataacctga agaatgatca ccttattcct     4020

tattcattaa ttttcttgat taatagggaa acttgggaat agctataaag taaaacttgg     4080

gtggaacctg gggccctggc atcacacaag tgtgattagg atggtcaagg tcatcaggag     4140

tacagcctat tatattccca catcctgaga aaggtcattt ctcccacaca cgacaaagtc     4200

acagacatcc tgcacctgcc actaggcatc ctcatcctac tgacatgccc atttctccag     4260

ttttcttaat ctgagactcc cttcccttgt tttttaaaga taccgtgctt ctccacatcc     4320

tcatccttca aggagcatat tttgctctta ggatggtctt tgggattcaa gaatagaata     4380

ataaatccaa acttggtcat tcccattttg aagagatgca agagggccca gtgaggacat     4440

ccgcctccct gaaagtggtg ctagacagag ctgaggtcat tgtatctgtg tatccacata     4500

ggatttctct taattcagct tgaattgatg gggagggagg taagagtagg gtcagagtta     4560

ctcatccctt ttcaaagaat tgtgggtgga agtttgtaaa ggccattcat ttgattttca     4620

aaatcaaagc gacagctcta cttccacttg gccttagatc tctgctatac cctgccatag     4680

ccttgatgcc actgggcaca agccacctgc caaatacagg agtggcctct cccagcctgg     4740

catgataggg gggtctgtgc cctcagatgt gttgacagct gctcttctga attgccacac     4800

ctgtgctaca cttggaattc tgtgctctga ctctgcaggg taggaccacg tgccatctca     4860

cacagaggtc aaccgatgag cccactcact cgtacatgcc ttcttccaca gtgggaagca     4920

tgatctggca ggggccgccc tgtaggctgg ggatgggctg ctgtgtgaat gttgacgttc     4980

gtttcatgga gaaaggggag gtgaaagatt gaagagcagg ttcctgtcaa tgttctgagt     5040

tcgagctgga ggtgtagatt gaatagtcta catggtctgt gagtgtgtga gatgaaccct     5100

tccatccttt gacacctggt tgtatgtgta ggctaagaag gaaggaccct cctgtcagtg     5160

tgcaaagctg taatctcatg gactagagga gagggggcca aggggatgga caggagaagt     5220

catgcagaat ctaagcagga atgcagatag aacacatcta ggctcttttc cccaggagag     5280

tgatgatgga gcatatagat ctggctcaaa ttcagcctcc atcacttacc agtcaggaac     5340

cctggcgata tcactttaac tttctgaacc tcagagtctt cacctataag acggggaaaa     5400

taataccacc ctttcaagat tgttgagata aataagtgat ataaaacatg taaagcttag     5460

ttctggccac agtgtagcta ctcaataaat gataatacta cc                        5502


<210>  42
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Glu Arg Glu Leu Trp Pro Ala Gly Thr Gly Ser Glu Pro Val 
1               5                   10                  15      


Thr Arg Val Gly Ser Cys Asp Ser Met Met Ser Ser Thr Ser Thr Arg 
            20                  25                  30          


Ser Gly Ser Ser Asp Ser Ser Tyr Asp Phe Leu Ser Thr Glu Glu Lys 
        35                  40                  45              


Glu Cys Leu Leu Phe Leu Glu Glu Thr Ile Gly Ser Leu Asp Thr Glu 
    50                  55                  60                  


Ala Asp Ser Gly Leu Ser Thr Asp Glu Ser Glu Pro Ala Thr Thr Pro 
65                  70                  75                  80  


Arg Gly Phe Arg Ala Leu Pro Ile Thr Gln Pro Thr Pro Arg Gly Gly 
                85                  90                  95      


Pro Glu Glu Thr Ile Thr Gln Gln Gly Arg Thr Pro Arg Thr Val Thr 
            100                 105                 110         


Glu Ser Ser Ser Ser His Pro Pro Glu Pro Gln Gly Leu Gly Leu Arg 
        115                 120                 125             


Ser Gly Ser Tyr Ser Leu Pro Arg Asn Ile His Ile Ala Arg Ser Gln 
    130                 135                 140                 


Asn Phe Arg Lys Ser Thr Thr Gln Ala Ser Ser His Asn Pro Gly Glu 
145                 150                 155                 160 


Pro Gly Arg Leu Ala Pro Glu Pro Glu Lys Glu Gln Val Ser Gln Ser 
                165                 170                 175     


Ser Gln Pro Arg Gln Ala Pro Ala Ser Pro Gln Glu Ala Ala Leu Asp 
            180                 185                 190         


Leu Asp Val Val Leu Ile Pro Pro Pro Glu Ala Phe Arg Asp Thr Gln 
        195                 200                 205             


Pro Glu Gln Cys Arg Glu Ala Ser Leu Pro Glu Gly Pro Gly Gln Gln 
    210                 215                 220                 


Gly His Thr Pro Gln Leu His Thr Pro Ser Ser Ser Gln Glu Arg Glu 
225                 230                 235                 240 


Gln Thr Pro Ser Glu Ala Met Ser Gln Lys Ala Lys Glu Thr Val Ser 
                245                 250                 255     


Thr Arg Tyr Thr Gln Pro Gln Pro Pro Pro Ala Gly Leu Pro Gln Asn 
            260                 265                 270         


Ala Arg Ala Glu Asp Ala Pro Leu Ser Ser Gly Glu Asp Pro Asn Ser 
        275                 280                 285             


Arg Leu Ala Pro Leu Thr Thr Pro Lys Pro Arg Lys Leu Pro Pro Asn 
    290                 295                 300                 


Ile Val Leu Lys Ser Ser Arg Ser Ser Phe His Ser Asp Pro Gln His 
305                 310                 315                 320 


Trp Leu Ser Arg His Thr Glu Ala Ala Pro Gly Asp Ser Gly Leu Ile 
                325                 330                 335     


Ser Cys Ser Leu Gln Glu Gln Arg Lys Ala Arg Lys Glu Ala Leu Glu 
            340                 345                 350         


Lys Leu Gly Leu Pro Gln Asp Gln Asp Glu Pro Gly Leu His Leu Ser 
        355                 360                 365             


Lys Pro Thr Ser Ser Ile Arg Pro Lys Glu Thr Arg Ala Gln His Leu 
    370                 375                 380                 


Ser Pro Ala Pro Gly Leu Ala Gln Pro Ala Ala Pro Ala Gln Ala Ser 
385                 390                 395                 400 


Ala Ala Ile Pro Ala Ala Gly Lys Ala Leu Ala Gln Ala Pro Ala Pro 
                405                 410                 415     


Ala Pro Gly Pro Ala Gln Gly Pro Leu Pro Met Lys Ser Pro Ala Pro 
            420                 425                 430         


Gly Asn Val Ala Ala Ser Lys Ser Met Pro Ile Ser Ile Pro Lys Ala 
        435                 440                 445             


Pro Arg Ala Asn Ser Ala Leu Thr Pro Pro Lys Pro Glu Ser Gly Leu 
    450                 455                 460                 


Thr Leu Gln Glu Ser Asn Thr Pro Gly Leu Arg Gln Met Asn Phe Lys 
465                 470                 475                 480 


Ser Asn Thr Leu Glu Arg Ser Gly Val Gly Leu Ser Ser Tyr Leu Ser 
                485                 490                 495     


Thr Glu Lys Asp Ala Ser Pro Lys Thr Ser Thr Ser Leu Gly Lys Gly 
            500                 505                 510         


Ser Phe Leu Asp Lys Ile Ser Pro Ser Val Leu Arg Asn Ser Arg Pro 
        515                 520                 525             


Arg Pro Ala Ser Leu Gly Thr Gly Lys Asp Phe Ala Gly Ile Gln Val 
    530                 535                 540                 


Gly Lys Leu Ala Asp Leu Glu Gln Glu Gln Ser Ser Lys Arg Leu Ser 
545                 550                 555                 560 


Tyr Gln Gly Gln Ser Arg Asp Lys Leu Pro Arg Pro Pro Cys Val Ser 
                565                 570                 575     


Val Lys Ile Ser Pro Lys Gly Val Pro Asn Glu His Arg Arg Glu Ala 
            580                 585                 590         


Leu Lys Lys Leu Gly Leu Leu Lys Glu 
        595                 600     


<210>  43
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  43
gttcctgaga gcacaagcac ccccaaatgt gaagtgcact cggacacaca cacacacaca       60

cacgcacgca cacacaagca ctcatgttct aaagagagag gtctgagtcc gaagttgctg      120

ctgctgggag cttgagctga gatggactgg tcttcatggg cgcccaaggc gctgggtgca      180

gctttccccg agacccccag atggaaagga gggaaggagg aaccccacac actcgccttt      240

tgcgagaaga tcggcgcgca ccccagagtg ccccaagcct ttggaatctg cctgctgagc      300

ggagcgcgcg agcgtggtgg acaggtcccg aacttggcca gcgggctttc ttggcaactt      360

gctttgcgca gttctccatg gaaccctgga cccactgtgc tcccggcgcc ttgccttttt      420

ttttcttttt ctttctctca ctgtctcttt ttaaatttat gaactcgaaa tgaagcggaa      480

agcagatatg cgcgtcagca tactttggcg ggatgctggc ccaccactag tattctctgg      540

tgctcgttgt gctttgggag atcttctatg caacatggaa accatgaatt gtaccacaga      600

gggagatctt ctgtcccact aggaaactgc gaattgtacc acagagggag atcttctatg      660

caacatggag accatgaatg gtacacacag agagagatct tctatccaca tggacaccat      720

gaattgtacc acagaggcag atgttctatc caacatggaa accatgaact gtacacacag      780

agggggatat tccatccaac ataggaacca tgaactgtac acacagaggg agatcttcta      840

tccaacatgg agaccatgaa ttttaccaca aaggaagatg ttctatccaa aatggaaacc      900

atgagttgta tgcctagagg gagatcttct atccaatatg taagccacga gttggacaca      960

cagagagaga tattttatcc aacttggaaa ccatgaattg tacacacaga gagatcttct     1020

atccaacacg gaaacaacga gttataccca cagggggaga tcttctatcc aattcaggtg     1080

ttccttatgt gatagcatac tctgcatcta caactagcta aag                       1123


<210>  44
<211>  1832
<212>  DNA
<213>  Homo sapiens

<400>  44
gttcctgaga gcacaagcac ccccaaatgt gaagtgcact cggacacaca cacacacaca       60

cacgcacgca cacacaagca ctcatgttct aaagagagag gtctgagtcc gaagttgctg      120

ctgctgggag cttgagctga gatggactgg tcttcatggg cgcccaaggc gctgggtgca      180

gctttccccg agacccccag atggaaagga gggaaggagg aaccccacac actcgccttt      240

tgcgagaaga tcggcgcgca ccccagagtg ccccaagcct ttggaatctg cctgctgagc      300

ggagcgcgcg agcgtggtgg acaggtcccg aacttggcca gcgggctttc ttggcaactt      360

gctttgcgca gttctccatg gaaccctgga cccactgtgc tcccggcgcc ttgccttttt      420

ttttcttttt ctttctctca ctgtctcttt ttaaatttat gaactcgaaa tgaagcggaa      480

agcagatatg cgcgtcagca tactttggcg gaccttttaa aaatggaact gtcggctgcg      540

gctggaaggc gcaggcaggc gccctggaga gaattcacag ggaggcacag gacagaacgc      600

tcccaggaac gaggaagcac ccccagaaag gagcgctcta tgggctccag gcagccgagg      660

aaacgcgaac gtgagccccg tgactgcact cccacgtgca ccaacgctgc cagtgtgagc      720

agaagcggag cccgcagagc gccaggctgc gccgggagat gcatcacgat gaaaaactgc      780

gccagagcat ggcgggaact ttccgagagg gcgtgttgtt tccaggcggt tccaccttct      840

aatatgaaac agtcttggtt gattttcctt gatactactt tatgctcggc ctggttgttg      900

gcaagtagct gcccgcgtct gtacgcgccc ttgattagtt tccactgcat gtgttttaac      960

acagtcctcc tttttccacg tttatttggg ccaaccctgt ctgcaaagat ccagtttaat     1020

acagatttga gtctacgtgc tatagcctgg aaatgtacta aagacactac aacatattgc     1080

tgaaagaata gaatctttat tctgaatgca aagcggacac ctagtaaaaa attctggaat     1140

aataaaacaa gcaaggctta tgtgctcagt tttggggacg ctccaattta aaggcttagt     1200

cattgtcacg gtgtaaggtt tacccattgc ccccatcaca cagatgtggg attgttgaga     1260

gctgagtgtc ctatgacctc ttctgctgcc caagaacttg gggtgggtgg taactggaga     1320

aatcaaagtg atcagctgca aagaacgctt ccattgctgg agcttggttg tgcgggattc     1380

tccacggagg tcttaaggca gagacaaaaa caaggacttt gggaggctcc tgtgagcagc     1440

caaaagggtt tagagtcagg cagcctcagg ttacaaatcc agtcctgcag gctaggagtt     1500

gtgtaagctt aaaaaagtga ctgcacttcc aggaacatca tttccctacc tgctcctcct     1560

tctgacgggt tttctgagga caatggaatc cacactctgt gtcgaacact tttctaatta     1620

gcgatgtgca gacactgttt attttacagg aataaaaatg ccagaagaac ccaagtcata     1680

ttcatttaaa gcagggtgac aagtacacca aaatctgaaa aatcatcact aaagaactta     1740

tccatgtaac caaaaaccat tgaaataaaa gtaaactatg gaaacaaaat ttaaaagtaa     1800

taaaatttaa aagtccaaaa aaaaaaaaaa aa                                   1832


<210>  45
<211>  2498
<212>  DNA
<213>  Homo sapiens

<400>  45
tttttttttt tttttttttt ggaaagcaag gatcacactt ccccctccct gttccttaat       60

cccttttcta aaaagggggg aaaatccgga tggattttag ggattggtct ggtgtcagct      120

gtgttttatt gcacacctaa atcctgatta taggcttttc atttctccgc aaagccttta      180

ttttggcagt taagccaaat gtgttttcca gaaagttagt tattttctcc tctttctttc      240

ctttctttcc tccctttttc ccgtctgacc ccaaacgtta ttgtccaaac atgactggac      300

agcagctttt gtttcttgac cctgtaatat gacagtctgc taatattgac agaaggtgca      360

gtttttgggt tatagtcgtg attttcgcta atcaatcata ttagcaggaa aaaaaatgac      420

ttgtttctgt tgtacttgag tcttaagaaa aagtgcccat agtttagtga caatttccaa      480

aggctttagt accacctgta tttcaaaatg ggggacccaa actcccggaa gaaacaagct      540

ctgaacagac tacgtgctca gcttagaaag aaaaaagaat ctctagctga ccagtttgac      600

ttcaagatgt atattgcctt tgtattcaag gagaagaaga aaaagtcagc actttttgaa      660

gtgtctgagg ttataccagt catgacaaat aattatgaag aaaatatcct gaaaggtgtg      720

cgagattcca gctattcctt ggaaagttcc ctagagcttt tacagaagga tgtggtacag      780

ctccatgctc ctcgatatca gtctatgaga agggatgtaa ttggctgtac tcaggagatg      840

gatttcattc tttggcctcg gaatgatatt gaaaaaatcg tctgtctcct gttttctagg      900

tggaaagaat ctgatgagcc ttttaggcct gttcaggcca aatttgagtt tcatcatggt      960

gactatgaaa aacagtttct gcatgtactg agccgcaagg acaagactgg aatcgttgtc     1020

aacaatccta accagtcagt gtttctcttc attgacagac agcacttgca gactccaaaa     1080

aacaaagcta caatcttcaa gttatgcagc atctgcctct acctgccaca ggaacagctc     1140

acccactggg cagttggcac catagaggat cacctccgtc cttatatgcc agagtagagt     1200

actgaccagc aaaatggaga agatcagaga atgcagcagc agtttttttt cttgttttct     1260

taccacttta ttctttcaga gtttaaagaa aatggactca tgcacagaac actatgcatt     1320

ttgaaacttg ttcatcctgg atttttttaa atcattttta tctcagaact taaacaaaaa     1380

ttagatgtcg tgcacggact gtgtgaaaga agatgctttg catatttgct gcactgcatc     1440

agtatcttac taaaaatgtg aaatgaaagg actattgtac actgaaatgc ttaaatgtat     1500

ctgaaagcac aaggtgatac tcatttttat ggtcttccca tttgtgctgg tttttgcctc     1560

tttgacatct gtcatcagta tttagagggt gagaagtgaa tgtaacaggt ataaataaca     1620

tttttaaaaa caataacttt gctataatca cagttgttcc agagcactgt cagatacatt     1680

ctaatgacca gaactggttt aaaaaaagaa aatacaacca tgggaaagaa atcttaaatg     1740

aaaaacgcat ctcattgtag gcatttttgc ctcatatttt actgggccat gtttgtttcc     1800

tggtactcat gtattttttt tttccagatc tctttcccca agttgctatt gtaagagtat     1860

tctgctgcgt gtggatgcag ttatacacat taaagcagat ctggagtctg aagtagctat     1920

aaagcagcta taaaacagaa atacatgcat agctgcagaa accatgatag gtagaggact     1980

tttcttttgg ttttgttttg ttttgttttg ttttgttttt ggttttacag agaagagatt     2040

tttattacaa agaaaaaaat tccagtgaat tgtgcagaaa tgctggtttt tacaccatcc     2100

taaagaaaaa ctttacaagg gtgttttgga gtagaaaaaa ggttataaag ttggaatctt     2160

aaattgtaaa attaaccatt gagtgtcaaa gttctaaaag cagaactcat tttgtgcaat     2220

gaacataagg aaagactact gtataggttt tttttttttt ctccttttaa atgaagaaaa     2280

gctttgctta agggttgcat acttttattg gagtaaatct gaatgatcct actcctttgg     2340

agtaaaacta gtgcttacca gtttccaatt gtatttagct tctggttgga atttgaaaaa     2400

aaaagaaaaa aagaaaaaga aaacctaaat aaaataggtg aaagttccct gactattcag     2460

gtgaatacac aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2498


<210>  46
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Asp Pro Asn Ser Arg Lys Lys Gln Ala Leu Asn Arg Leu Arg 
1               5                   10                  15      


Ala Gln Leu Arg Lys Lys Lys Glu Ser Leu Ala Asp Gln Phe Asp Phe 
            20                  25                  30          


Lys Met Tyr Ile Ala Phe Val Phe Lys Glu Lys Lys Lys Lys Ser Ala 
        35                  40                  45              


Leu Phe Glu Val Ser Glu Val Ile Pro Val Met Thr Asn Asn Tyr Glu 
    50                  55                  60                  


Glu Asn Ile Leu Lys Gly Val Arg Asp Ser Ser Tyr Ser Leu Glu Ser 
65                  70                  75                  80  


Ser Leu Glu Leu Leu Gln Lys Asp Val Val Gln Leu His Ala Pro Arg 
                85                  90                  95      


Tyr Gln Ser Met Arg Arg Asp Val Ile Gly Cys Thr Gln Glu Met Asp 
            100                 105                 110         


Phe Ile Leu Trp Pro Arg Asn Asp Ile Glu Lys Ile Val Cys Leu Leu 
        115                 120                 125             


Phe Ser Arg Trp Lys Glu Ser Asp Glu Pro Phe Arg Pro Val Gln Ala 
    130                 135                 140                 


Lys Phe Glu Phe His His Gly Asp Tyr Glu Lys Gln Phe Leu His Val 
145                 150                 155                 160 


Leu Ser Arg Lys Asp Lys Thr Gly Ile Val Val Asn Asn Pro Asn Gln 
                165                 170                 175     


Ser Val Phe Leu Phe Ile Asp Arg Gln His Leu Gln Thr Pro Lys Asn 
            180                 185                 190         


Lys Ala Thr Ile Phe Lys Leu Cys Ser Ile Cys Leu Tyr Leu Pro Gln 
        195                 200                 205             


Glu Gln Leu Thr His Trp Ala Val Gly Thr Ile Glu Asp His Leu Arg 
    210                 215                 220                 


Pro Tyr Met Pro Glu 
225                 


<210>  47
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  47
acccgcaggt ggcgccccac gtccgtgttt gcgccctcag ccgagctcca ggcgcagctg       60

ggaaacccag cgcgtctccc cgggtccttt gagcgagcgc ggacaccgca atttaataaa      120

taagcgcaag cgccagccgc tccaccagtc cgaggtccag aggagcagac acacagaccc      180

gggccggagg cccctcttct agccctgcgg gaaccggaca gttccccaac tgggactctg      240

gaaccacagc tcctaaatca tcaaattctc aagctttttt tttccctctc ttcgtcccag      300

ccatcccagt cttcttcttc tttttttttt ttttaactta ttgttttttt cgctcctgtc      360

attatgaaag tggtcacgcc attcaatatt aagacttgga gggaattggg gaaagaaaag      420

aaagaatcta aaagaagaga agcgaccggt gcttttaagg gtgtctaatt ttcaaaagag      480

acgtctggga gtattttgct ctgggcgttt ggagcaactt cgcggacagc ggagctcgcc      540

cagcatggat gttccaggtt cacaggcgcc tttcttctga gaacgaccct ggccttgaac      600

gtcagagccg gggacgaagg cccccggagg ctgctgcgag ctccgcgcgt tccttcgcgc      660

ccttccgcgc cgctcgcgcc ggcgccggcc tccacccccg cgcgccgcct cccaccagtc      720

ccgatgcagg cgcccggccg ggggccactc gggctgcggc tgatgatgcc cgggcgccgg      780

ggggcgctgc gcgagccggg cggctgcgga tcctgcctgg gggtggcgct ggccctgctg      840

ttgctgctac tgcccgcctg ctgccccgtg cgggcgcaga acgacacgga gcccatcgtg      900

ctggagggca agtgcctggt ggtgtgcgac tccagcccgt cggcggacgg cgccgtcacc      960

tcctccctag gcatctccgt gcgctccggc agcgccaagg tggccttctc cgccacgcgg     1020

agcaccaacc acgagccgtc cgagatgagc aaccgcacca tgaccatcta tttcgaccag     1080

gtattagtaa atattggcaa ccactttgat cttgcttcca gtatatttgt agcaccgaga     1140

aaagggattt atagcttcag cttccacgtg gtcaaagtgt ataacagaca aaccatccag     1200

gtcagtttaa tgcagaatgg ctacccagtg atctcggcct ttgcaggaga ccaggatgtc     1260

accagagaag ctgctagcaa tggcgtgctg ctgctcatgg aaagggaaga caaagtgcat     1320

ctcaaacttg agagaggcaa cctcatgggg ggctggaaat actccacatt ctcgggcttc     1380

ttggtgtttc ctctataaac acagagcccc ctagatggtg ggggaatggc aaactggacc     1440

caggactccg ccctttaaaa caccctgaac ttactggaat tggacacctt gtttccaacc     1500

tccgtcagac tgttgcagta gaagaatgat ttcctttgaa acctccagta cttttgtttt     1560

tgttttttgg aatactgaca attcctcggg aacctggcct ctaattagtt ttagatgaca     1620

aggtcttaag gagaaatgaa attatcgatt tgagcaattt gtacctgtga ttgtaaagtc     1680

aatatcggat tttattgttg ggaccatgga cctcttttgt ttgtatgttg tattgtcgtc     1740

ccaacggaag gagagctcct gactccagga tgggctgcag gttgcagtca gggcttgaag     1800

taggagccca gcaaagaacc acctgctgga cagtccttga catgtgttct gtgtgtgtct     1860

gtatagcctt aagaaaaaga atggcttcac tttcattctg tattcttccc cccaccatgt     1920

ggctgggagg acttgggagg gggatgggga cattgggaac ctgtcaagaa gtgctttatc     1980

cagagaagca aattttgcac gattggactg caatttttgt tttgtattgt ttgtgttttt     2040

tcttgaaaag ctttactttt ctttccacac tcagctctcc ctcctcaacc ccacttttat     2100

ttttcttgct ggggttgagg agagaaaata tagaattcct ggataagacc aaacaaaaca     2160

aaacattaaa atacctgtat gttttgtttt agacgagacc aaactaaaca aaaagtatct     2220

gtttatcaaa gtaaaagtaa cacaatggac aattctgctt attctctcaa agagattcta     2280

agatgcacct ttagaactat taatagcaac ctgcattttt ttttaattta tacttcagaa     2340

tcctttaaga acctggtgtt cctgagtggt cctgaatcat ataagttggt aatggaagct     2400

gtaatgacca agtcccctaa acatactatg tctttgccac gtgtgctgtg acttctctgt     2460

gggtgattta atttatttgg atccacctct gagtgagcgc acagtgatca ggtgcttcaa     2520

agccaacaga ccagctcctc ttcctccgga tcctcttttg atctgcccag gaaagggatg     2580

cattgacact ctcctgcatg cacctggcga gaagccacct gaaagtcact gtggttaaag     2640

atattggtgg aggtacccca ggagcactgt tacaaatcct tcttgttttg gcatctcgta     2700

caacattatt aagacacagc tgagagttga tgggtgtgta atgcatatgc caaggaaatg     2760

tcactaatcc caaagcaatc aaaaaggaga cctcaaacca gatgttaatt tgttctttgt     2820

gtaacaatgt aaccaaaata ttgatgataa aagtcataat ttaagattca gaataaatgg     2880

gtttgatgtc tggcaaaaaa aaaaaaaaaa                                      2910


<210>  48
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gln Ala Pro Gly Arg Gly Pro Leu Gly Leu Arg Leu Met Met Pro 
1               5                   10                  15      


Gly Arg Arg Gly Ala Leu Arg Glu Pro Gly Gly Cys Gly Ser Cys Leu 
            20                  25                  30          


Gly Val Ala Leu Ala Leu Leu Leu Leu Leu Leu Pro Ala Cys Cys Pro 
        35                  40                  45              


Val Arg Ala Gln Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys 
    50                  55                  60                  


Leu Val Val Cys Asp Ser Ser Pro Ser Ala Asp Gly Ala Val Thr Ser 
65                  70                  75                  80  


Ser Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe Ser 
                85                  90                  95      


Ala Thr Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg Thr 
            100                 105                 110         


Met Thr Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn His Phe 
        115                 120                 125             


Asp Leu Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser 
    130                 135                 140                 


Phe Ser Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val 
145                 150                 155                 160 


Ser Leu Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp 
                165                 170                 175     


Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met 
            180                 185                 190         


Glu Arg Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met 
        195                 200                 205             


Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
    210                 215                 220                 


<210>  49
<211>  2997
<212>  DNA
<213>  Homo sapiens

<400>  49
cctggccagc gctgctggcg ggcgttaggc ggccaccatg ctgccactgg gctcagagcc       60

cgccctgaat gagctgctgc ttcgcaagga ggaggagtgg agggcgctgc aggcacaccg      120

cacccagctg caggaggcgg ctctgcagga cacacggagc cagctggagg aggcgcaggg      180

gaaactgcgg tgcctgcagg aggactttgt ctacaacctt caggtgctgg aggagcggga      240

cctcgagctg gagcgctatg acgccgcctt cgcccaggcc agggagtggg aagaggccag      300

gcgggcagag gtgagcgagc tcaagataga ggcagctaag ctgaggcagg cgctagccag      360

agaggccagg aaggtggagg agctgcagca gcagcagcag ctggcattcc aggagcatcg      420

cctggagctg gagcgcgtcc acagtgacaa gaatggtgag attgaccacc accgggaaca      480

gtatgaaaat ctaaaatgga cactggagag aaaacttgag gagctcgacg gtgagcttgc      540

tctgcagaga caggaactgc tgctggagtt tgaatcgaaa atgcggaaga gggagcacga      600

attccgtctg caggctgaca acatgagcaa cacagccttg tcccgggagc ttaaggttaa      660

actactgcac aaagagctgg aggctctgaa ggaagccggg gcaaaggctg cagagagtct      720

gcagagggca gaggccacca acgccgagct ggagaggaag ctccagagcc gagccgggga      780

gctccaggac ctggaggcca tgagccgcgc ccgggtaaag gatttagagg ataaacttca      840

ctctgtgcag ctaaccagga agaaggaaga ggaaacattt aagaggaagc atgaggagct      900

cgaccgtctg gccagggaga aggatgcagt gctggtggcg gtgaagggag cccacgtgga      960

gcagctgcag gagctgcaga ccagggttct ggagctgcag gcccactgcg agaccctcga     1020

ggcgcagctc cgcagggcag agtggagaca ggctgacacc gccaaggaga aggacgctgc     1080

cattgaccaa cttcgtgaag atgcatcaac tgtaaaatct gcctgggatg ctcaaattgc     1140

tcaactatct aaggagatgg tctccagaga ccttcagatt cagacgctgc aggaagaaga     1200

ggtgaagctc aaggcacagg tggcccgatc ccagcaggac attgaaaggt acaagcaaca     1260

gctgtccctg gcagtggaaa gggagcggag cctggagcgt gatcaggtgc agctgggcct     1320

ggactggcag cgccgctgtg atgacattga aagggaccag atccaaaagt cagaggccct     1380

gattcagggt ctgagcatgg caaaaagtca ggttgctgcc aagctgcagg agacagagca     1440

ggcgctacag gagcaggagg tggtgctgaa ggccgtgacc ctggaacgag accaggccgt     1500

gcaggccctg aggatgcatg ggctccccag accaggggca cagatgcttc tcaggcagca     1560

tgaagaagaa ataagtaaag actttccatc cagtgagatc cagcggctcc gagagcagaa     1620

cacgagcttg cgaaacgcga ttgcccagat gaggaaagaa atggaggctc taagccatca     1680

gattcctcct cccatccaga cagcggcaga gagcacagat gcaaaccagc ctgacccaga     1740

ggctggggga gatgccgcca ctcctgatta tgttctggcc cttgaagcag aaatacgaac     1800

tctaaagcat aagtttaaaa ctctggaaaa gcatctagaa gatgtgttgg atcctttaaa     1860

gatgtcctca cctcatgctg agtctcagcc cagcgtccgc acctcgacag agacgactgg     1920

agggtctgcc caagctggtc aagccggagg gtctgtccaa gctggtcaag caggaggatc     1980

tgtccaagct ggcccagtat cctctggact ggcactcagg aagctcgggg acagagtgca     2040

gctcctaaac ctgctggtga cacgactcag acagaaggtg ctgcgggaac ccctggagcc     2100

ggccgctctc cagcgtgagc ttccccgtga ggtggaccag gtacacctgg aggttttgga     2160

gctgcggaag caggtggctg agctggggaa gcatctcagg atagcccagc acgggggagc     2220

ggagccttca ggcaggaagc agcccccagc ctcggacgcc gtggcccttg ggagagagga     2280

cgccaagagt gccgaggatg aggctccttc cagacacttg ggaaagcacc agccccgctc     2340

agcacaggtg ggcagcagac ttgacgccct gcaaggcccg aagacacaac acagcatcca     2400

cacggtgacc tgtaaatcac ctcggcagaa agaagacagg tccccaaagc caccccaggc     2460

tccccagcac cctgaggagc atggtcgcca atcccacagc tcctcctcct ttgccagtgg     2520

caccctccag gacatgtgga ggttgctaga cctgggatcc agcccttctg gtgtcacctc     2580

ccagggtgac tcaactccag agctcccagc tcctccagca gccgacagga ggcccgtcaa     2640

gatgcaggca ggcattgcca ccccagggat gaagacagca gcccaggcaa aggccaagac     2700

cacaggagcc tcccggtctc atcctgcaaa agctaaaggc tgccagaggc cccccaagat     2760

ccgtaactac aacattatgg actgacttcc tccccccacc ccgccccact aaggggtgct     2820

cggggcctcc gcatggtgcc tgtgctttca cctacgtgtt gtgggggggt gtgggcacag     2880

cgtgcagggt ggaggcaggg agctgcaggg caggctccca aatgctgctg aggcgaccct     2940

gctgactgaa ggcctccctg agcacagggc ccattaaaac caggttcctc cctgggg        2997


<210>  50
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Leu Pro Leu Gly Ser Glu Pro Ala Leu Asn Glu Leu Leu Leu Arg 
1               5                   10                  15      


Lys Glu Glu Glu Trp Arg Ala Leu Gln Ala His Arg Thr Gln Leu Gln 
            20                  25                  30          


Glu Ala Ala Leu Gln Asp Thr Arg Ser Gln Leu Glu Glu Ala Gln Gly 
        35                  40                  45              


Lys Leu Arg Cys Leu Gln Glu Asp Phe Val Tyr Asn Leu Gln Val Leu 
    50                  55                  60                  


Glu Glu Arg Asp Leu Glu Leu Glu Arg Tyr Asp Ala Ala Phe Ala Gln 
65                  70                  75                  80  


Ala Arg Glu Trp Glu Glu Ala Arg Arg Ala Glu Val Ser Glu Leu Lys 
                85                  90                  95      


Ile Glu Ala Ala Lys Leu Arg Gln Ala Leu Ala Arg Glu Ala Arg Lys 
            100                 105                 110         


Val Glu Glu Leu Gln Gln Gln Gln Gln Leu Ala Phe Gln Glu His Arg 
        115                 120                 125             


Leu Glu Leu Glu Arg Val His Ser Asp Lys Asn Gly Glu Ile Asp His 
    130                 135                 140                 


His Arg Glu Gln Tyr Glu Asn Leu Lys Trp Thr Leu Glu Arg Lys Leu 
145                 150                 155                 160 


Glu Glu Leu Asp Gly Glu Leu Ala Leu Gln Arg Gln Glu Leu Leu Leu 
                165                 170                 175     


Glu Phe Glu Ser Lys Met Arg Lys Arg Glu His Glu Phe Arg Leu Gln 
            180                 185                 190         


Ala Asp Asn Met Ser Asn Thr Ala Leu Ser Arg Glu Leu Lys Val Lys 
        195                 200                 205             


Leu Leu His Lys Glu Leu Glu Ala Leu Lys Glu Ala Gly Ala Lys Ala 
    210                 215                 220                 


Ala Glu Ser Leu Gln Arg Ala Glu Ala Thr Asn Ala Glu Leu Glu Arg 
225                 230                 235                 240 


Lys Leu Gln Ser Arg Ala Gly Glu Leu Gln Asp Leu Glu Ala Met Ser 
                245                 250                 255     


Arg Ala Arg Val Lys Asp Leu Glu Asp Lys Leu His Ser Val Gln Leu 
            260                 265                 270         


Thr Arg Lys Lys Glu Glu Glu Thr Phe Lys Arg Lys His Glu Glu Leu 
        275                 280                 285             


Asp Arg Leu Ala Arg Glu Lys Asp Ala Val Leu Val Ala Val Lys Gly 
    290                 295                 300                 


Ala His Val Glu Gln Leu Gln Glu Leu Gln Thr Arg Val Leu Glu Leu 
305                 310                 315                 320 


Gln Ala His Cys Glu Thr Leu Glu Ala Gln Leu Arg Arg Ala Glu Trp 
                325                 330                 335     


Arg Gln Ala Asp Thr Ala Lys Glu Lys Asp Ala Ala Ile Asp Gln Leu 
            340                 345                 350         


Arg Glu Asp Ala Ser Thr Val Lys Ser Ala Trp Asp Ala Gln Ile Ala 
        355                 360                 365             


Gln Leu Ser Lys Glu Met Val Ser Arg Asp Leu Gln Ile Gln Thr Leu 
    370                 375                 380                 


Gln Glu Glu Glu Val Lys Leu Lys Ala Gln Val Ala Arg Ser Gln Gln 
385                 390                 395                 400 


Asp Ile Glu Arg Tyr Lys Gln Gln Leu Ser Leu Ala Val Glu Arg Glu 
                405                 410                 415     


Arg Ser Leu Glu Arg Asp Gln Val Gln Leu Gly Leu Asp Trp Gln Arg 
            420                 425                 430         


Arg Cys Asp Asp Ile Glu Arg Asp Gln Ile Gln Lys Ser Glu Ala Leu 
        435                 440                 445             


Ile Gln Gly Leu Ser Met Ala Lys Ser Gln Val Ala Ala Lys Leu Gln 
    450                 455                 460                 


Glu Thr Glu Gln Ala Leu Gln Glu Gln Glu Val Val Leu Lys Ala Val 
465                 470                 475                 480 


Thr Leu Glu Arg Asp Gln Ala Val Gln Ala Leu Arg Met His Gly Leu 
                485                 490                 495     


Pro Arg Pro Gly Ala Gln Met Leu Leu Arg Gln His Glu Glu Glu Ile 
            500                 505                 510         


Ser Lys Asp Phe Pro Ser Ser Glu Ile Gln Arg Leu Arg Glu Gln Asn 
        515                 520                 525             


Thr Ser Leu Arg Asn Ala Ile Ala Gln Met Arg Lys Glu Met Glu Ala 
    530                 535                 540                 


Leu Ser His Gln Ile Pro Pro Pro Ile Gln Thr Ala Ala Glu Ser Thr 
545                 550                 555                 560 


Asp Ala Asn Gln Pro Asp Pro Glu Ala Gly Gly Asp Ala Ala Thr Pro 
                565                 570                 575     


Asp Tyr Val Leu Ala Leu Glu Ala Glu Ile Arg Thr Leu Lys His Lys 
            580                 585                 590         


Phe Lys Thr Leu Glu Lys His Leu Glu Asp Val Leu Asp Pro Leu Lys 
        595                 600                 605             


Met Ser Ser Pro His Ala Glu Ser Gln Pro Ser Val Arg Thr Ser Thr 
    610                 615                 620                 


Glu Thr Thr Gly Gly Ser Ala Gln Ala Gly Gln Ala Gly Gly Ser Val 
625                 630                 635                 640 


Gln Ala Gly Gln Ala Gly Gly Ser Val Gln Ala Gly Pro Val Ser Ser 
                645                 650                 655     


Gly Leu Ala Leu Arg Lys Leu Gly Asp Arg Val Gln Leu Leu Asn Leu 
            660                 665                 670         


Leu Val Thr Arg Leu Arg Gln Lys Val Leu Arg Glu Pro Leu Glu Pro 
        675                 680                 685             


Ala Ala Leu Gln Arg Glu Leu Pro Arg Glu Val Asp Gln Val His Leu 
    690                 695                 700                 


Glu Val Leu Glu Leu Arg Lys Gln Val Ala Glu Leu Gly Lys His Leu 
705                 710                 715                 720 


Arg Ile Ala Gln His Gly Gly Ala Glu Pro Ser Gly Arg Lys Gln Pro 
                725                 730                 735     


Pro Ala Ser Asp Ala Val Ala Leu Gly Arg Glu Asp Ala Lys Ser Ala 
            740                 745                 750         


Glu Asp Glu Ala Pro Ser Arg His Leu Gly Lys His Gln Pro Arg Ser 
        755                 760                 765             


Ala Gln Val Gly Ser Arg Leu Asp Ala Leu Gln Gly Pro Lys Thr Gln 
    770                 775                 780                 


His Ser Ile His Thr Val Thr Cys Lys Ser Pro Arg Gln Lys Glu Asp 
785                 790                 795                 800 


Arg Ser Pro Lys Pro Pro Gln Ala Pro Gln His Pro Glu Glu His Gly 
                805                 810                 815     


Arg Gln Ser His Ser Ser Ser Ser Phe Ala Ser Gly Thr Leu Gln Asp 
            820                 825                 830         


Met Trp Arg Leu Leu Asp Leu Gly Ser Ser Pro Ser Gly Val Thr Ser 
        835                 840                 845             


Gln Gly Asp Ser Thr Pro Glu Leu Pro Ala Pro Pro Ala Ala Asp Arg 
    850                 855                 860                 


Arg Pro Val Lys Met Gln Ala Gly Ile Ala Thr Pro Gly Met Lys Thr 
865                 870                 875                 880 


Ala Ala Gln Ala Lys Ala Lys Thr Thr Gly Ala Ser Arg Ser His Pro 
                885                 890                 895     


Ala Lys Ala Lys Gly Cys Gln Arg Pro Pro Lys Ile Arg Asn Tyr Asn 
            900                 905                 910         


Ile Met Asp 
        915 


<210>  51
<211>  3075
<212>  DNA
<213>  Homo sapiens

<400>  51
agatgcatga agattcagct gtgaagatac tataaaaagg gaagagaagg accgagacag       60

aagcaacaac ggaactgtca gtgcggagta gggctaaact cagttccatt gttaagcaag      120

gaaaaacaaa caatacattg aatttgacaa cccactgaag ttgcagataa tgaggactta      180

ccattatata ccattattca tctggaccta tatgttccat acagttgaca ccatcctatt      240

acaagaaaaa cctaacagtt atttatcaag caaaaagata gcgggtctga caaaagatga      300

cggtaaaatg ctacgtcgca ccaagcgtgg ctggatgtgg aatcagttct tcttattgga      360

agagtacaca ggtactgaca cacaatatgt aggcaagctt cacactgacc aagataaagg      420

agatggaaat ttaaaataca tactaacagg agatggggct ggcagtctat ttgttataga      480

tgaaaataca ggagacattc atgctgcaaa gaaactagac agagaagaaa aatctctgta      540

cattcttcgt gccaaggcta tagacagaaa aactgggcgg caggtggaac cggaatcgga      600

atttatcatt aaaatacatg atatcaatga caatgagcca aaatttacaa aagacttata      660

cactgccagt gttcctgaaa tgtctggagt cggtacatct gttatacaag taactgcaac      720

agatgcagat gacgccaact atggaaatag tgccaaagtg gtctatagca tattgcaagg      780

acagccatat ttttcagtgg acccagaatc aggcataata aaaactgcat taccagacat      840

gagcagagaa aatagagagc agtaccaggt tgttatacag gccaaagaca tgggtggcca      900

gatgggaggc ctttctggaa ccaccacagt gaacatcacg ctgacagatg tcaacaacaa      960

ccctcctcga tttccccaga gtacgtatca atttaattct cctgagtctg tacctcttgg     1020

aactcatctt ggaaggataa aagccaatga ccctgacgtg ggggaaaatg cagaaatgga     1080

gtatagcatt gctgaaggag atggtgcaga catgttcgat gtcatcactg acaaggatac     1140

acaggaaggg attataactg tcaaacagaa tttagatttt gaaaatcaaa tgctctatac     1200

tttaagagtg gatgcaagta acactcaccc tgatccacga ttcttacacc tgggaccttt     1260

caaagataca gctgtggtca aaatatctgt ggaagatata gatgagcctc ctgtgttcac     1320

taaagtctct tacttgatag aagtagatga agatgtaaag gagggcagta tcattggaca     1380

ggttacagca tacgatccag atgccaggaa caatttaata aagtactctg ttgatcggca     1440

tactgatatg gaccgtattt ttggtattca ctcagaaaat ggttctattt tcactttgaa     1500

agcccttgac cgggaatcat ctccttggca taacatcact gttacagcca cagaaataaa     1560

taacccaaaa caaagtagcc acatccctgt cttcatcaga attctagata taaatgacca     1620

tgctccggaa tttgccatgt attatgaaac atttgtttgt gaaaatgcaa aacctgggca     1680

gttgattcag actgtcagtg tcatggataa ggatgaccct ccccgaggtc acaaattctt     1740

ttttgaacca gtgccagaat ttactctcaa tccgaatttc accattgtag ataataaaga     1800

taatacagca ggaatcatga ctcggaaaga tggctacagt cgcaacaaaa tgagcaccta     1860

cttattgccg attttaatct ttgacaacga ttatccaatt caaagcagca ctggtacact     1920

cactatccgt gtgtgtgcct gcgataatca aggaaacatg caatcctgca ccgcagaagc     1980

cctgatcctt tcagccggcc tgagcacggg agctctcgtt gcgattctac tctgtgtcct     2040

catactgctt attttagtcg tgttgtttgc tgcattgaag aggcaaagaa aaaaggaacc     2100

tctgataatt tcaaaagacg atgtccggga caacattgtg acctacaacg atgaaggcgg     2160

cggggaagaa gatacccaag cttttgacat tggcacatta aggaatccag aggcaagaga     2220

agacagtaaa cttagacggg atgtaatgcc tgaaactatt tttcagataa ggaggactgt     2280

gcctctgtgg gaaaatattg atgtacaaga ttttatccat cgaagattaa aagaaaacga     2340

cgcagaccca agtgcacctc catatgattc gctggcaacg tatgcctatg aagggaatga     2400

ttccatagca gattcgctca gttctttgga atctctcaca gctgattgta accaagatta     2460

tgattacctc agtgactggg ggcctcgttt caaaaaactt gccgatatgt atgggggtga     2520

tgatagtgac cgagactaag aggattgttt gacttaatca atattagtgg aagtactgtc     2580

tatgttatta gattgagtgg cctgcattct cttcctggga ggaaatcttt caaaaattga     2640

agttacaaac aatacgtaga tgttgtcaag tagggatttg cttaatcagt aagtctttgt     2700

gaatgaatac gaatgataca gatttttaaa aaagtaataa ccagttcacc ctctttgcct     2760

aacaatctcg gaaggaaaat atatcacatc aataatcaat aaaaataagt aaaaggcttt     2820

ttgtgccttt tcttaggtat aataatttat aaatgttttc ttaactgact ttcagtcacc     2880

tttacaatta aactaaatat tgtgcaaccg ctttgtaaat taatatgaag aagatatatc     2940

cctaatgaaa taggaatgac tattactgcc atatttattt agttgaagaa tgtctttgtg     3000

ttaattcatt catattttta taaatgtata tttatatttt tgtattttta tgaaataaac     3060

tagtatttat aaaac                                                      3075


<210>  52
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Arg Thr Tyr His Tyr Ile Pro Leu Phe Ile Trp Thr Tyr Met Phe 
1               5                   10                  15      


His Thr Val Asp Thr Ile Leu Leu Gln Glu Lys Pro Asn Ser Tyr Leu 
            20                  25                  30          


Ser Ser Lys Lys Ile Ala Gly Leu Thr Lys Asp Asp Gly Lys Met Leu 
        35                  40                  45              


Arg Arg Thr Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Thr Asp Thr Gln Tyr Val Gly Lys Leu His Thr Asp 
65                  70                  75                  80  


Gln Asp Lys Gly Asp Gly Asn Leu Lys Tyr Ile Leu Thr Gly Asp Gly 
                85                  90                  95      


Ala Gly Ser Leu Phe Val Ile Asp Glu Asn Thr Gly Asp Ile His Ala 
            100                 105                 110         


Ala Lys Lys Leu Asp Arg Glu Glu Lys Ser Leu Tyr Ile Leu Arg Ala 
        115                 120                 125             


Lys Ala Ile Asp Arg Lys Thr Gly Arg Gln Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Lys Phe Thr 
145                 150                 155                 160 


Lys Asp Leu Tyr Thr Ala Ser Val Pro Glu Met Ser Gly Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Thr Asp Ala Asp Asp Ala Asn Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Glu Ser Gly Ile Ile Lys Thr Ala Leu Pro Asp Met 
    210                 215                 220                 


Ser Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asn Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Asn Ser Pro Glu Ser Val Pro Leu Gly Thr His Leu Gly 
        275                 280                 285             


Arg Ile Lys Ala Asn Asp Pro Asp Val Gly Glu Asn Ala Glu Met Glu 
    290                 295                 300                 


Tyr Ser Ile Ala Glu Gly Asp Gly Ala Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Gln Asn Leu Asp 
                325                 330                 335     


Phe Glu Asn Gln Met Leu Tyr Thr Leu Arg Val Asp Ala Ser Asn Thr 
            340                 345                 350         


His Pro Asp Pro Arg Phe Leu His Leu Gly Pro Phe Lys Asp Thr Ala 
        355                 360                 365             


Val Val Lys Ile Ser Val Glu Asp Ile Asp Glu Pro Pro Val Phe Thr 
    370                 375                 380                 


Lys Val Ser Tyr Leu Ile Glu Val Asp Glu Asp Val Lys Glu Gly Ser 
385                 390                 395                 400 


Ile Ile Gly Gln Val Thr Ala Tyr Asp Pro Asp Ala Arg Asn Asn Leu 
                405                 410                 415     


Ile Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Gly 
            420                 425                 430         


Ile His Ser Glu Asn Gly Ser Ile Phe Thr Leu Lys Ala Leu Asp Arg 
        435                 440                 445             


Glu Ser Ser Pro Trp His Asn Ile Thr Val Thr Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser His Ile Pro Val Phe Ile Arg Ile Leu Asp 
465                 470                 475                 480 


Ile Asn Asp His Ala Pro Glu Phe Ala Met Tyr Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Asn Ala Lys Pro Gly Gln Leu Ile Gln Thr Val Ser Val Met 
            500                 505                 510         


Asp Lys Asp Asp Pro Pro Arg Gly His Lys Phe Phe Phe Glu Pro Val 
        515                 520                 525             


Pro Glu Phe Thr Leu Asn Pro Asn Phe Thr Ile Val Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Met Thr Arg Lys Asp Gly Tyr Ser Arg Asn Lys 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Ile Leu Ile Phe Asp Asn Asp Tyr Pro 
                565                 570                 575     


Ile Gln Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp 
            580                 585                 590         


Asn Gln Gly Asn Met Gln Ser Cys Thr Ala Glu Ala Leu Ile Leu Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ile Leu Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Asp Asp Val Arg Asp Asn Ile 
                645                 650                 655     


Val Thr Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Arg Glu Asp Ser Lys Leu 
        675                 680                 685             


Arg Arg Asp Val Met Pro Glu Thr Ile Phe Gln Ile Arg Arg Thr Val 
    690                 695                 700                 


Pro Leu Trp Glu Asn Ile Asp Val Gln Asp Phe Ile His Arg Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Ala Asp Pro Ser Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Asn Asp Ser Ile Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Leu Thr Ala Asp Cys Asn Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Asp 
    770                 775                 780                 


Asp Ser Asp Arg Asp 
785                 


<210>  53
<211>  5097
<212>  DNA
<213>  Homo sapiens

<400>  53
tcgcggtaac agcctccgtg gcctccggag gaccatgtca ttagactttg gcagtgtggc       60

actaccagtg caaaatgaag atgaagagta tgacgaagag gactatgaaa gagagaaaga      120

gttgcagcag ttactcacag accttcccca tgacatgctg gatgacgacc tctcctctcc      180

agagctccag tattcggact gcagcgagga tggcacagac ggacaaccac atcatcctga      240

gcaattggag atgagctgga atgagcaaat gctgcccaaa tctcaaagtg taaatggcta      300

taatgaaatt cagagtttat atgctggaga aaaatgtggt aatgtctggg aagaaaatag      360

aagtaaaact gaagaccgac atcctgtgta ccatcctgaa gaaggtggag atgaaggtgg      420

aagtggttat agtcctccaa gtaaatgtga acagactgat ttatatcacc ttcctgaaaa      480

ctttaggcca tataccaatg gtcagaagca ggaatttaat aaccaagcaa ccaatgtaat      540

taaattttca gatcctcaat ggaaccattt tcagggtccc agttgtcaag gtttggaacc      600

gtataataaa gtgacatata aaccttatca gtcttctgcc cagaataatg gctcaccagc      660

ccaggagata acaggaagtg acacattcga aggcctgcaa caacaatttt taggagctaa      720

tgagaactct gcagaaaata tgcagattat tcaacttcag gttcttaaca aagcaaaaga      780

gagacaactg gagaacttaa ttgaaaagtt aaatgaaagt gaacgtcaaa ttcgatatct      840

gaatcaccag cttgtaataa taaaagatga aaaggatggt ttgactctca gccttcgaga      900

atcacagaaa ctctttcaga atggaaaaga aagagagata cagcttgaag ctcaaataaa      960

agcactggag actcagatac aagcattaaa agtcaatgaa gaacagatga tcaagaagtc     1020

cagaacaact gaaatggctc tggaaagctt gaagcagcag ctggtggacc ttcatcattc     1080

tgaatcactt caacgagcta gagaacagca tgagagcatt gttatgggcc tcacaaagaa     1140

gtacgaagag caagtattgt ccttacaaaa gaatttggat gccacagtca ccgcacttaa     1200

agaacaggaa gacatttgct ctcgtctgaa agatcacgtg aaacaactgg aaaggaatca     1260

agaagcaatc aagttagaaa agactgagat cattaataag ttgacaagaa gtctagagga     1320

gagtcaaaag cagtgtgccc acttgttgca gtccgggtca gtacaagagg tggctcagct     1380

acagttccag ctgcagcaag cacagaaggc acatgctatg agtgcaaaca tgaacaaggc     1440

tttgcaagaa gaattaacag aactaaaaga tgaaatttct ctctatgaat ctgctgcaaa     1500

actaggaata catccaagtg actcagaagg agaattaaat atagaactca ctgaatcgta     1560

tgtggatttg ggtattaaaa aggtcaactg gaaaaaatcc aaagttacca gcattgtaca     1620

agaagaagac ccaaatgaag agctttcaaa agatgagttc attctgaagt taaaggcaga     1680

agtacagcgt ttgctgggta gcaactcaat gaagcgtcat ctggtgtctc agttacaaaa     1740

tgacctcaaa gactgtcata agaaaattga agatctccac caagtgaaga aggatgaaaa     1800

aagcattgag gttgagacta aaacagatac ctcagaaaaa ccaaagaatc aattatggcc     1860

tgagtcttct acttctgatg ttgtcagaga tgatattctg ctgcttaaaa atgaaattca     1920

agttttacaa caacaaaatc aggaacttaa agaaactgaa ggaaaactga gaaatacaaa     1980

tcaagactta tgtaatcaaa tgagacaaat ggtacaagat tttgaccatg acaaacaaga     2040

agctgtggat aggtgtgaaa ggacttatca gcagcaccat gaagccatga aaactcaaat     2100

acgtgaaagc ctattagcaa agcatgcttt ggagaagcag cagctctttg aggcttatga     2160

gagaactcat ttgcaactga ggtctgagtt ggataagttg aataaggagg tgactgctgt     2220

gcaggaatgt tacctagaag tgtgcagaga gaaggataat ctagaattga ctctcaggaa     2280

gaccactgaa aaggagcaac agactcagga gaagatcaaa gaaaaactca ttcaacagct     2340

tgaaaaggag tggcagtcta agctggatca aactataaag gcaatgaaaa agaagacctt     2400

agattgtggc agccaaactg accaagtaac caccagtgat gttatttcca agaaagagat     2460

ggcaattatg atagaagagc agaagtgcac aatccagcaa aacttagaac aagagaagga     2520

catagccatc aagggggcta tgaagaaact cgaaattgaa ttggaactca aacattgtga     2580

aaatattacc aaacaggtag aaatagctgt gcaaaatgct catcagcgat ggctgggaga     2640

actaccagag ctggcagagt atcaagcact tgtgaaggca gaacagaaaa agtgggaaga     2700

acagcatgag gtctctgtga acaaaaggat atcatttgct gtttctgaag ctaaagagaa     2760

atggaagagt gagcttgaaa atatgaggaa aaatatactt cctggaaagg aattggaaga     2820

gaagattcat tctcttcaga aggaacttga gttaaagaac gaagaagtcc ctgtggtcat     2880

cagggctgag ttagctaagg ctcggagtga atggaacaaa gaaaagcaag aagaaatcca     2940

cagaatccaa gaacaaaatg agcaagatta ccggcaattt ttagatgatc accgaaataa     3000

aattaatgag gtgcttgcgg cagctaaaga agactttatg aaacaaaaaa ctgaactact     3060

tcttcagaag gagacagaat tacaaacttg tctagaccag agtcgtagag aatggactat     3120

gcaggaagcc aagcggatcc aactggaaat ctatcagtat gaggaagaca tcctgactgt     3180

acttggggtt cttttaagtg atacccaaaa ggagcacatc agtgattctg aggacaagca     3240

gcttttggaa atcatgtcga cttgttcttc aaaatggatg tctgtgcaat attttgaaaa     3300

actaaagggc tgcatacaga aagcatttca agatacactt cctctgcttg tagaaaacgc     3360

tgacccagaa tggaaaaaga gaaatatggc cgagctctct aaggattctg ccagccaggg     3420

cactggccaa ggagaccctg gacctgctgc tggacaccat gctcagccct tggccttaca     3480

agcaacagaa gcagaagctg aagagaataa taaagttgtt gaagaattaa tagaagaaaa     3540

caacgacatg aagaataaat tggaagaatt gcaaacactt tgtaaaacac caccaaggtc     3600

attgtcagca ggggccattg aaaatgcttg cctgccatgc agtgggggag ccttggaaga     3660

acttcgtggg cagtacatta aagctgtaaa aaaaattaaa tgtgacatgc ttcgttatat     3720

tcaggagagt aaggaacgag ctgcagaaat ggtaaaagca gaggtactgc gagaacgtca     3780

agaaaccgcc cgaaagatgc gcaaatatta tttgatttgc ctccaacaga ttttgcagga     3840

tgatggaaaa gaaggggctg agaaaaagat tatgaatgct gctagcaaac ttgctacaat     3900

ggcaaaatta ctggaaacac ctatttctag taagtcccaa agcaaaacta cacagtcagc     3960

actgccccta acttcagaga tgctgattgc agttaaaaaa tcaaaaagaa atgatgtgaa     4020

tcagaaaata ccatgttgta ttgaaagcaa atcaaatagt gtaaacacca tcaccagaac     4080

tctgtgcgaa caagctccca agaggagggc agcttgtaac ttacaaaggc tgttagagaa     4140

ctcagagcat cagagcataa agcatgtggg atccaaagag acacatttgg aattccagtt     4200

tggggatggt agttgcaagc acctaaacag tttgccaagg aatgtttctc ctgagtttgt     4260

tccttgtgaa ggtgaaggag gctttggttt gcacaagaag aaagacctac tcagtgataa     4320

tggttctgaa tcacttccgc attcagctgc ataccccttt cttggaacct taggaaataa     4380

accctcacct agatgtaccc ctggtccttc tgaatcagga tgcatgcata taacctttcg     4440

cgattctaat gaaagacttg gtttaaaagt atataaatgc aatccactaa tggaaagtga     4500

aaatgctgca tctgagaaaa gtcaaggttt ggatgttcag gaacctccag taaaagatgg     4560

aggggacctt agtgactgct tgggctggcc ttccagcagt gcaaccttat cctttgacag     4620

tcgtgaagca tcatttgtac atggtaggcc acaaggaact ttggaaatac caagtgaatc     4680

tgttaaatcc aaacagtttt caccatccgg ttatctttca gatacagagg aaagtaatat     4740

gatttgtcaa acaatgaaat gtcagcgtta tcaaactcca tacctgtcag aagaaaccac     4800

gtatttggag ccaggaaaga tcagtgtgaa ttgtggacac ccatctcgtc ataaggctga     4860

tagattaaag tcagatttca aaaaactgag cagtacatta ccatcttcag tgtgtcagca     4920

gccttcaaga aaattaattg ttccgctatc tagccaacaa gatagtggct ttgatagccc     4980

atttgttaat ctagactaat tatggtacag tatttaagaa gaatcattaa tatattaaca     5040

aaaatggaag ggaagacctc atactgaaaa aaattgtgag ccctgcctct tttgaga        5097


<210>  54
<211>  1654
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Leu Asp Phe Gly Ser Val Ala Leu Pro Val Gln Asn Glu Asp 
1               5                   10                  15      


Glu Glu Tyr Asp Glu Glu Asp Tyr Glu Arg Glu Lys Glu Leu Gln Gln 
            20                  25                  30          


Leu Leu Thr Asp Leu Pro His Asp Met Leu Asp Asp Asp Leu Ser Ser 
        35                  40                  45              


Pro Glu Leu Gln Tyr Ser Asp Cys Ser Glu Asp Gly Thr Asp Gly Gln 
    50                  55                  60                  


Pro His His Pro Glu Gln Leu Glu Met Ser Trp Asn Glu Gln Met Leu 
65                  70                  75                  80  


Pro Lys Ser Gln Ser Val Asn Gly Tyr Asn Glu Ile Gln Ser Leu Tyr 
                85                  90                  95      


Ala Gly Glu Lys Cys Gly Asn Val Trp Glu Glu Asn Arg Ser Lys Thr 
            100                 105                 110         


Glu Asp Arg His Pro Val Tyr His Pro Glu Glu Gly Gly Asp Glu Gly 
        115                 120                 125             


Gly Ser Gly Tyr Ser Pro Pro Ser Lys Cys Glu Gln Thr Asp Leu Tyr 
    130                 135                 140                 


His Leu Pro Glu Asn Phe Arg Pro Tyr Thr Asn Gly Gln Lys Gln Glu 
145                 150                 155                 160 


Phe Asn Asn Gln Ala Thr Asn Val Ile Lys Phe Ser Asp Pro Gln Trp 
                165                 170                 175     


Asn His Phe Gln Gly Pro Ser Cys Gln Gly Leu Glu Pro Tyr Asn Lys 
            180                 185                 190         


Val Thr Tyr Lys Pro Tyr Gln Ser Ser Ala Gln Asn Asn Gly Ser Pro 
        195                 200                 205             


Ala Gln Glu Ile Thr Gly Ser Asp Thr Phe Glu Gly Leu Gln Gln Gln 
    210                 215                 220                 


Phe Leu Gly Ala Asn Glu Asn Ser Ala Glu Asn Met Gln Ile Ile Gln 
225                 230                 235                 240 


Leu Gln Val Leu Asn Lys Ala Lys Glu Arg Gln Leu Glu Asn Leu Ile 
                245                 250                 255     


Glu Lys Leu Asn Glu Ser Glu Arg Gln Ile Arg Tyr Leu Asn His Gln 
            260                 265                 270         


Leu Val Ile Ile Lys Asp Glu Lys Asp Gly Leu Thr Leu Ser Leu Arg 
        275                 280                 285             


Glu Ser Gln Lys Leu Phe Gln Asn Gly Lys Glu Arg Glu Ile Gln Leu 
    290                 295                 300                 


Glu Ala Gln Ile Lys Ala Leu Glu Thr Gln Ile Gln Ala Leu Lys Val 
305                 310                 315                 320 


Asn Glu Glu Gln Met Ile Lys Lys Ser Arg Thr Thr Glu Met Ala Leu 
                325                 330                 335     


Glu Ser Leu Lys Gln Gln Leu Val Asp Leu His His Ser Glu Ser Leu 
            340                 345                 350         


Gln Arg Ala Arg Glu Gln His Glu Ser Ile Val Met Gly Leu Thr Lys 
        355                 360                 365             


Lys Tyr Glu Glu Gln Val Leu Ser Leu Gln Lys Asn Leu Asp Ala Thr 
    370                 375                 380                 


Val Thr Ala Leu Lys Glu Gln Glu Asp Ile Cys Ser Arg Leu Lys Asp 
385                 390                 395                 400 


His Val Lys Gln Leu Glu Arg Asn Gln Glu Ala Ile Lys Leu Glu Lys 
                405                 410                 415     


Thr Glu Ile Ile Asn Lys Leu Thr Arg Ser Leu Glu Glu Ser Gln Lys 
            420                 425                 430         


Gln Cys Ala His Leu Leu Gln Ser Gly Ser Val Gln Glu Val Ala Gln 
        435                 440                 445             


Leu Gln Phe Gln Leu Gln Gln Ala Gln Lys Ala His Ala Met Ser Ala 
    450                 455                 460                 


Asn Met Asn Lys Ala Leu Gln Glu Glu Leu Thr Glu Leu Lys Asp Glu 
465                 470                 475                 480 


Ile Ser Leu Tyr Glu Ser Ala Ala Lys Leu Gly Ile His Pro Ser Asp 
                485                 490                 495     


Ser Glu Gly Glu Leu Asn Ile Glu Leu Thr Glu Ser Tyr Val Asp Leu 
            500                 505                 510         


Gly Ile Lys Lys Val Asn Trp Lys Lys Ser Lys Val Thr Ser Ile Val 
        515                 520                 525             


Gln Glu Glu Asp Pro Asn Glu Glu Leu Ser Lys Asp Glu Phe Ile Leu 
    530                 535                 540                 


Lys Leu Lys Ala Glu Val Gln Arg Leu Leu Gly Ser Asn Ser Met Lys 
545                 550                 555                 560 


Arg His Leu Val Ser Gln Leu Gln Asn Asp Leu Lys Asp Cys His Lys 
                565                 570                 575     


Lys Ile Glu Asp Leu His Gln Val Lys Lys Asp Glu Lys Ser Ile Glu 
            580                 585                 590         


Val Glu Thr Lys Thr Asp Thr Ser Glu Lys Pro Lys Asn Gln Leu Trp 
        595                 600                 605             


Pro Glu Ser Ser Thr Ser Asp Val Val Arg Asp Asp Ile Leu Leu Leu 
    610                 615                 620                 


Lys Asn Glu Ile Gln Val Leu Gln Gln Gln Asn Gln Glu Leu Lys Glu 
625                 630                 635                 640 


Thr Glu Gly Lys Leu Arg Asn Thr Asn Gln Asp Leu Cys Asn Gln Met 
                645                 650                 655     


Arg Gln Met Val Gln Asp Phe Asp His Asp Lys Gln Glu Ala Val Asp 
            660                 665                 670         


Arg Cys Glu Arg Thr Tyr Gln Gln His His Glu Ala Met Lys Thr Gln 
        675                 680                 685             


Ile Arg Glu Ser Leu Leu Ala Lys His Ala Leu Glu Lys Gln Gln Leu 
    690                 695                 700                 


Phe Glu Ala Tyr Glu Arg Thr His Leu Gln Leu Arg Ser Glu Leu Asp 
705                 710                 715                 720 


Lys Leu Asn Lys Glu Val Thr Ala Val Gln Glu Cys Tyr Leu Glu Val 
                725                 730                 735     


Cys Arg Glu Lys Asp Asn Leu Glu Leu Thr Leu Arg Lys Thr Thr Glu 
            740                 745                 750         


Lys Glu Gln Gln Thr Gln Glu Lys Ile Lys Glu Lys Leu Ile Gln Gln 
        755                 760                 765             


Leu Glu Lys Glu Trp Gln Ser Lys Leu Asp Gln Thr Ile Lys Ala Met 
    770                 775                 780                 


Lys Lys Lys Thr Leu Asp Cys Gly Ser Gln Thr Asp Gln Val Thr Thr 
785                 790                 795                 800 


Ser Asp Val Ile Ser Lys Lys Glu Met Ala Ile Met Ile Glu Glu Gln 
                805                 810                 815     


Lys Cys Thr Ile Gln Gln Asn Leu Glu Gln Glu Lys Asp Ile Ala Ile 
            820                 825                 830         


Lys Gly Ala Met Lys Lys Leu Glu Ile Glu Leu Glu Leu Lys His Cys 
        835                 840                 845             


Glu Asn Ile Thr Lys Gln Val Glu Ile Ala Val Gln Asn Ala His Gln 
    850                 855                 860                 


Arg Trp Leu Gly Glu Leu Pro Glu Leu Ala Glu Tyr Gln Ala Leu Val 
865                 870                 875                 880 


Lys Ala Glu Gln Lys Lys Trp Glu Glu Gln His Glu Val Ser Val Asn 
                885                 890                 895     


Lys Arg Ile Ser Phe Ala Val Ser Glu Ala Lys Glu Lys Trp Lys Ser 
            900                 905                 910         


Glu Leu Glu Asn Met Arg Lys Asn Ile Leu Pro Gly Lys Glu Leu Glu 
        915                 920                 925             


Glu Lys Ile His Ser Leu Gln Lys Glu Leu Glu Leu Lys Asn Glu Glu 
    930                 935                 940                 


Val Pro Val Val Ile Arg Ala Glu Leu Ala Lys Ala Arg Ser Glu Trp 
945                 950                 955                 960 


Asn Lys Glu Lys Gln Glu Glu Ile His Arg Ile Gln Glu Gln Asn Glu 
                965                 970                 975     


Gln Asp Tyr Arg Gln Phe Leu Asp Asp His Arg Asn Lys Ile Asn Glu 
            980                 985                 990         


Val Leu Ala Ala Ala Lys Glu Asp  Phe Met Lys Gln Lys  Thr Glu Leu 
        995                 1000                 1005             


Leu Leu  Gln Lys Glu Thr Glu  Leu Gln Thr Cys Leu  Asp Gln Ser 
    1010                 1015                 1020             


Arg Arg  Glu Trp Thr Met Gln  Glu Ala Lys Arg Ile  Gln Leu Glu 
    1025                 1030                 1035             


Ile Tyr  Gln Tyr Glu Glu Asp  Ile Leu Thr Val Leu  Gly Val Leu 
    1040                 1045                 1050             


Leu Ser  Asp Thr Gln Lys Glu  His Ile Ser Asp Ser  Glu Asp Lys 
    1055                 1060                 1065             


Gln Leu  Leu Glu Ile Met Ser  Thr Cys Ser Ser Lys  Trp Met Ser 
    1070                 1075                 1080             


Val Gln  Tyr Phe Glu Lys Leu  Lys Gly Cys Ile Gln  Lys Ala Phe 
    1085                 1090                 1095             


Gln Asp  Thr Leu Pro Leu Leu  Val Glu Asn Ala Asp  Pro Glu Trp 
    1100                 1105                 1110             


Lys Lys  Arg Asn Met Ala Glu  Leu Ser Lys Asp Ser  Ala Ser Gln 
    1115                 1120                 1125             


Gly Thr  Gly Gln Gly Asp Pro  Gly Pro Ala Ala Gly  His His Ala 
    1130                 1135                 1140             


Gln Pro  Leu Ala Leu Gln Ala  Thr Glu Ala Glu Ala  Glu Glu Asn 
    1145                 1150                 1155             


Asn Lys  Val Val Glu Glu Leu  Ile Glu Glu Asn Asn  Asp Met Lys 
    1160                 1165                 1170             


Asn Lys  Leu Glu Glu Leu Gln  Thr Leu Cys Lys Thr  Pro Pro Arg 
    1175                 1180                 1185             


Ser Leu  Ser Ala Gly Ala Ile  Glu Asn Ala Cys Leu  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ala Leu Glu Glu Leu  Arg Gly Gln Tyr Ile  Lys Ala Val 
    1205                 1210                 1215             


Lys Lys  Ile Lys Cys Asp Met  Leu Arg Tyr Ile Gln  Glu Ser Lys 
    1220                 1225                 1230             


Glu Arg  Ala Ala Glu Met Val  Lys Ala Glu Val Leu  Arg Glu Arg 
    1235                 1240                 1245             


Gln Glu  Thr Ala Arg Lys Met  Arg Lys Tyr Tyr Leu  Ile Cys Leu 
    1250                 1255                 1260             


Gln Gln  Ile Leu Gln Asp Asp  Gly Lys Glu Gly Ala  Glu Lys Lys 
    1265                 1270                 1275             


Ile Met  Asn Ala Ala Ser Lys  Leu Ala Thr Met Ala  Lys Leu Leu 
    1280                 1285                 1290             


Glu Thr  Pro Ile Ser Ser Lys  Ser Gln Ser Lys Thr  Thr Gln Ser 
    1295                 1300                 1305             


Ala Leu  Pro Leu Thr Ser Glu  Met Leu Ile Ala Val  Lys Lys Ser 
    1310                 1315                 1320             


Lys Arg  Asn Asp Val Asn Gln  Lys Ile Pro Cys Cys  Ile Glu Ser 
    1325                 1330                 1335             


Lys Ser  Asn Ser Val Asn Thr  Ile Thr Arg Thr Leu  Cys Glu Gln 
    1340                 1345                 1350             


Ala Pro  Lys Arg Arg Ala Ala  Cys Asn Leu Gln Arg  Leu Leu Glu 
    1355                 1360                 1365             


Asn Ser  Glu His Gln Ser Ile  Lys His Val Gly Ser  Lys Glu Thr 
    1370                 1375                 1380             


His Leu  Glu Phe Gln Phe Gly  Asp Gly Ser Cys Lys  His Leu Asn 
    1385                 1390                 1395             


Ser Leu  Pro Arg Asn Val Ser  Pro Glu Phe Val Pro  Cys Glu Gly 
    1400                 1405                 1410             


Glu Gly  Gly Phe Gly Leu His  Lys Lys Lys Asp Leu  Leu Ser Asp 
    1415                 1420                 1425             


Asn Gly  Ser Glu Ser Leu Pro  His Ser Ala Ala Tyr  Pro Phe Leu 
    1430                 1435                 1440             


Gly Thr  Leu Gly Asn Lys Pro  Ser Pro Arg Cys Thr  Pro Gly Pro 
    1445                 1450                 1455             


Ser Glu  Ser Gly Cys Met His  Ile Thr Phe Arg Asp  Ser Asn Glu 
    1460                 1465                 1470             


Arg Leu  Gly Leu Lys Val Tyr  Lys Cys Asn Pro Leu  Met Glu Ser 
    1475                 1480                 1485             


Glu Asn  Ala Ala Ser Glu Lys  Ser Gln Gly Leu Asp  Val Gln Glu 
    1490                 1495                 1500             


Pro Pro  Val Lys Asp Gly Gly  Asp Leu Ser Asp Cys  Leu Gly Trp 
    1505                 1510                 1515             


Pro Ser  Ser Ser Ala Thr Leu  Ser Phe Asp Ser Arg  Glu Ala Ser 
    1520                 1525                 1530             


Phe Val  His Gly Arg Pro Gln  Gly Thr Leu Glu Ile  Pro Ser Glu 
    1535                 1540                 1545             


Ser Val  Lys Ser Lys Gln Phe  Ser Pro Ser Gly Tyr  Leu Ser Asp 
    1550                 1555                 1560             


Thr Glu  Glu Ser Asn Met Ile  Cys Gln Thr Met Lys  Cys Gln Arg 
    1565                 1570                 1575             


Tyr Gln  Thr Pro Tyr Leu Ser  Glu Glu Thr Thr Tyr  Leu Glu Pro 
    1580                 1585                 1590             


Gly Lys  Ile Ser Val Asn Cys  Gly His Pro Ser Arg  His Lys Ala 
    1595                 1600                 1605             


Asp Arg  Leu Lys Ser Asp Phe  Lys Lys Leu Ser Ser  Thr Leu Pro 
    1610                 1615                 1620             


Ser Ser  Val Cys Gln Gln Pro  Ser Arg Lys Leu Ile  Val Pro Leu 
    1625                 1630                 1635             


Ser Ser  Gln Gln Asp Ser Gly  Phe Asp Ser Pro Phe  Val Asn Leu 
    1640                 1645                 1650             


Asp 
    


<210>  55
<211>  3273
<212>  DNA
<213>  Homo sapiens

<400>  55
aatgaggacg cgtggacgcg cggcacgccg gtcctggcta caggcgcggc gtttgaagaa       60

aaactgtcac tgaagagtca tggtggggcc cgggcctacc gctgctgccg ctgtcgaaga      120

gcggcagaga aagcttcagg agtaccttgc agccaaggga aaactgaaga gccaaaacac      180

caagccttat ctaaaatcca agaataattg ccagaatcaa ccaccttcta aatctactat      240

tagacccaaa aatgatgtta ccaaccatgt tgttttgcct gtcaaaccta aaaggtccat      300

cagcattaaa ctccagccca gaccacctaa tactgcaggg tcccagaagc cgaagttgga      360

gccaccaaaa cttctgggca aaaggctgac ttcagaatgt gtttcttcta acccatactc      420

taagccttct agcaagagtt ttcaacagtg tgaagctgga tcgtccacaa caggagaact      480

gtcaagaaaa cctgtggggt cacttaatat agagcaattg aaaactacaa agcagcagtt      540

aacagatcaa ggaaatggta aatgtataga ctttatgaat aatatccatg ttgaaaacga      600

atctttggat aactttctaa aagaaacaaa caaagagaac ttgctcgata tcttaacaga      660

acctgagagg aagccagatc ctaaattata taccagaagt aagccaaaga ctgactctta      720

taatcaaacc aagaacagtt tagttcctaa acaagccttg ggcaaaagtt cagttaatag      780

tgctgttctg aaagataggg ttaataaaca atttgttgga gaaacacaaa gcaggacttt      840

cccagtaaaa tcacagcaac tctctagagg agcagatctt gcaagaccag gagtaaaacc      900

ctcaaggacg gttccctctc actttattcg gacccttagt aaagttcagt catcaaagaa      960

accagtagtc aagaacatca aagatataaa ggttaatagg agtcaatatg aaagaccaaa     1020

tgaaactaag atacggtcat accctgttac tgaacagaga gtgaagcaca ccaaacccag     1080

aacatacccc agtttgcttc agggtgaata taacaacaga catccaaaca tcaagcaaga     1140

tcagaagtcc agccaagttt gtatacctca gacatcatgt gtactgcaaa agtcaaaagc     1200

cataagccag aggcctaatt tgacagttgg cagatttaat tcagccattc caagcacccc     1260

tagcataaga ccaaatggaa ccagtggtaa taaacataac aataatggct ttcagcaaaa     1320

agcacagact ttggactcca agttgaaaaa ggctgttccc cagaaccatt ttctgaacaa     1380

gacagctccc aaaactcaag ctgatgtcac aaccgtaaat gggacccaaa caaacccaaa     1440

tattaaaaag aaggcaacag cagaggatcg aaggaaacaa ctagaagaat ggcagaaatc     1500

taagggaaaa acctataaac ggcctcctat ggaacttaaa acaaaaagaa aagtaataaa     1560

ggaaatgaat atttcattct ggaagagcat tgaaaaagaa gaggaagaaa agaaagcaca     1620

actcgaactg tccagtaaaa ttaacaacac tctgacagaa tgtctgaacc tcatcgaagg     1680

gggtgtacct tctaatgaaa tacttaacat attgtccagc attcctgaag ctgaaaaatt     1740

tgctaaattc tggatctgca aagcaaagtt gttggcaagt aaaggcacct ttgatgttat     1800

tgggctatat gaagaggcca ttaaaaatgg ggcaacacca atacaagagt tgcggaaagt     1860

tgttcttaat atcttgcaag actcaaacag aaccacagaa gggattactt ctgactcttt     1920

agttgctgaa actagtataa catcagtgga agagctggcc aagaagatgg aatctgtgaa     1980

gtcttgtctt tctccaaaag agagggaaca agtcacggcg acaccccgaa tagccaaggc     2040

agaacagcat aattatcctg gtatcaaatt acagattggt ccaatcccta gaataaatgg     2100

gatgccggaa gtgcaagaca tgaaatttat cactcctgta cggcgttcgt cgaggattga     2160

gcgagcagtg tcccgctacc cagaaatgct gcaggaacac gatttagtag tggcttctct     2220

tgatgaactg ttagaagtgg aagaaacaaa atgttttata ttccgtagaa atgaggcgct     2280

gcctgtaaca ttggggtttc aaacccctga atcataattt cttgatgctt tttttaaaaa     2340

aggtgtttca gaaccaacat aagacaagaa atattcttgt ccaagtgacc tggaaaaaaa     2400

gagaggcatc atggatgcag attatggacg ctcaggactt aagtaattca ctgggcttac     2460

tctcaaattt tctctcccca tgggaaaatc tttgctttat gtgtttaaga ccagtttgcc     2520

agttttacag tatacataaa tttcaaactt ttgaatattt accctacaac tatgataaat     2580

atttatactt tattgatcta ctttaatccc aacatagttt tttatatcag aaggttggtc     2640

ccacaatata atgggacttt tctttctgca tccaccttag cagagggcaa gttctttcat     2700

cgtggaagat ctgaactttg acgctagctt gacaggctga atggaccttg acagatggcc     2760

aagtcaaaac ccctcatttt acagatgagt ttatgctagc tgtgcctttg ctcagagatc     2820

ataaatttat gtgtgatctt tgactttcat cacagtatcc ttgtaaatga gagagaattc     2880

ttgttttttc tatgccaggt ctcctcagat gaaacacaat cctgaattgg catggtcgtc     2940

tagcttttat attcaaacct agttttgcat ttgttactca gaaacacttc aagtaacaaa     3000

aggggggcag gggagagggg tggggagtgg acacttgctt cttcagttct ttgctcagct     3060

agggtatagc tggcctgaga aggcagtgca agccccagag actgttgtag gttgcttttt     3120

cttcctcctg ggcaactatt tgtggaaagg ttttacctta gtcattatgt aaatataatt     3180

gtgtagaaaa acctagtcaa cacattttaa attttagctt tcttaatatt taagtattat     3240

cttaaaacaa cattaaattt ctattagttc ctg                                  3273


<210>  56
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Gly Pro Gly Pro Thr Ala Ala Ala Ala Val Glu Glu Arg Gln 
1               5                   10                  15      


Arg Lys Leu Gln Glu Tyr Leu Ala Ala Lys Gly Lys Leu Lys Ser Gln 
            20                  25                  30          


Asn Thr Lys Pro Tyr Leu Lys Ser Lys Asn Asn Cys Gln Asn Gln Pro 
        35                  40                  45              


Pro Ser Lys Ser Thr Ile Arg Pro Lys Asn Asp Val Thr Asn His Val 
    50                  55                  60                  


Val Leu Pro Val Lys Pro Lys Arg Ser Ile Ser Ile Lys Leu Gln Pro 
65                  70                  75                  80  


Arg Pro Pro Asn Thr Ala Gly Ser Gln Lys Pro Lys Leu Glu Pro Pro 
                85                  90                  95      


Lys Leu Leu Gly Lys Arg Leu Thr Ser Glu Cys Val Ser Ser Asn Pro 
            100                 105                 110         


Tyr Ser Lys Pro Ser Ser Lys Ser Phe Gln Gln Cys Glu Ala Gly Ser 
        115                 120                 125             


Ser Thr Thr Gly Glu Leu Ser Arg Lys Pro Val Gly Ser Leu Asn Ile 
    130                 135                 140                 


Glu Gln Leu Lys Thr Thr Lys Gln Gln Leu Thr Asp Gln Gly Asn Gly 
145                 150                 155                 160 


Lys Cys Ile Asp Phe Met Asn Asn Ile His Val Glu Asn Glu Ser Leu 
                165                 170                 175     


Asp Asn Phe Leu Lys Glu Thr Asn Lys Glu Asn Leu Leu Asp Ile Leu 
            180                 185                 190         


Thr Glu Pro Glu Arg Lys Pro Asp Pro Lys Leu Tyr Thr Arg Ser Lys 
        195                 200                 205             


Pro Lys Thr Asp Ser Tyr Asn Gln Thr Lys Asn Ser Leu Val Pro Lys 
    210                 215                 220                 


Gln Ala Leu Gly Lys Ser Ser Val Asn Ser Ala Val Leu Lys Asp Arg 
225                 230                 235                 240 


Val Asn Lys Gln Phe Val Gly Glu Thr Gln Ser Arg Thr Phe Pro Val 
                245                 250                 255     


Lys Ser Gln Gln Leu Ser Arg Gly Ala Asp Leu Ala Arg Pro Gly Val 
            260                 265                 270         


Lys Pro Ser Arg Thr Val Pro Ser His Phe Ile Arg Thr Leu Ser Lys 
        275                 280                 285             


Val Gln Ser Ser Lys Lys Pro Val Val Lys Asn Ile Lys Asp Ile Lys 
    290                 295                 300                 


Val Asn Arg Ser Gln Tyr Glu Arg Pro Asn Glu Thr Lys Ile Arg Ser 
305                 310                 315                 320 


Tyr Pro Val Thr Glu Gln Arg Val Lys His Thr Lys Pro Arg Thr Tyr 
                325                 330                 335     


Pro Ser Leu Leu Gln Gly Glu Tyr Asn Asn Arg His Pro Asn Ile Lys 
            340                 345                 350         


Gln Asp Gln Lys Ser Ser Gln Val Cys Ile Pro Gln Thr Ser Cys Val 
        355                 360                 365             


Leu Gln Lys Ser Lys Ala Ile Ser Gln Arg Pro Asn Leu Thr Val Gly 
    370                 375                 380                 


Arg Phe Asn Ser Ala Ile Pro Ser Thr Pro Ser Ile Arg Pro Asn Gly 
385                 390                 395                 400 


Thr Ser Gly Asn Lys His Asn Asn Asn Gly Phe Gln Gln Lys Ala Gln 
                405                 410                 415     


Thr Leu Asp Ser Lys Leu Lys Lys Ala Val Pro Gln Asn His Phe Leu 
            420                 425                 430         


Asn Lys Thr Ala Pro Lys Thr Gln Ala Asp Val Thr Thr Val Asn Gly 
        435                 440                 445             


Thr Gln Thr Asn Pro Asn Ile Lys Lys Lys Ala Thr Ala Glu Asp Arg 
    450                 455                 460                 


Arg Lys Gln Leu Glu Glu Trp Gln Lys Ser Lys Gly Lys Thr Tyr Lys 
465                 470                 475                 480 


Arg Pro Pro Met Glu Leu Lys Thr Lys Arg Lys Val Ile Lys Glu Met 
                485                 490                 495     


Asn Ile Ser Phe Trp Lys Ser Ile Glu Lys Glu Glu Glu Glu Lys Lys 
            500                 505                 510         


Ala Gln Leu Glu Leu Ser Ser Lys Ile Asn Asn Thr Leu Thr Glu Cys 
        515                 520                 525             


Leu Asn Leu Ile Glu Gly Gly Val Pro Ser Asn Glu Ile Leu Asn Ile 
    530                 535                 540                 


Leu Ser Ser Ile Pro Glu Ala Glu Lys Phe Ala Lys Phe Trp Ile Cys 
545                 550                 555                 560 


Lys Ala Lys Leu Leu Ala Ser Lys Gly Thr Phe Asp Val Ile Gly Leu 
                565                 570                 575     


Tyr Glu Glu Ala Ile Lys Asn Gly Ala Thr Pro Ile Gln Glu Leu Arg 
            580                 585                 590         


Lys Val Val Leu Asn Ile Leu Gln Asp Ser Asn Arg Thr Thr Glu Gly 
        595                 600                 605             


Ile Thr Ser Asp Ser Leu Val Ala Glu Thr Ser Ile Thr Ser Val Glu 
    610                 615                 620                 


Glu Leu Ala Lys Lys Met Glu Ser Val Lys Ser Cys Leu Ser Pro Lys 
625                 630                 635                 640 


Glu Arg Glu Gln Val Thr Ala Thr Pro Arg Ile Ala Lys Ala Glu Gln 
                645                 650                 655     


His Asn Tyr Pro Gly Ile Lys Leu Gln Ile Gly Pro Ile Pro Arg Ile 
            660                 665                 670         


Asn Gly Met Pro Glu Val Gln Asp Met Lys Phe Ile Thr Pro Val Arg 
        675                 680                 685             


Arg Ser Ser Arg Ile Glu Arg Ala Val Ser Arg Tyr Pro Glu Met Leu 
    690                 695                 700                 


Gln Glu His Asp Leu Val Val Ala Ser Leu Asp Glu Leu Leu Glu Val 
705                 710                 715                 720 


Glu Glu Thr Lys Cys Phe Ile Phe Arg Arg Asn Glu Ala Leu Pro Val 
                725                 730                 735     


Thr Leu Gly Phe Gln Thr Pro Glu Ser 
            740                 745 


<210>  57
<211>  8575
<212>  DNA
<213>  Homo sapiens

<400>  57
agactggcga aagtgatgag tctaaaaaag tagtccctcc ggttcctctg tttcccccca       60

tgtggcgtca ggaagcgagg caccgggcgc actgcgcccc gaattcctgc gcccgccgcg      120

cgcggcgctc cgtggagggg tacataaggc ggagggggtg aggcgactgg gcggagttct      180

gtcgccggga tccttccgct gggctcagcc gtttccggag tctgcgctgc gcccggttcc      240

gccattgcgg ctctcctggc ccctggagcc tccgcccccg acccgagctc tttcgtctgc      300

ctgccagttt cctgcgtccc cggagaggat cctgctgagc ccagcctccc ccctcccctt      360

ctcctcctct cccttggaga gcccgggcag ccactgcccc gcagccccag tgacaggagg      420

agaccataac ccccgacagc gccatggccc agattctgcc aattcgtttt caggagcatc      480

tccagctcca gaacctgggt atcaacccag caaacattgg cttcagtacc ctgactatgg      540

agtctgacaa attcatctgc attagagaaa aagtaggaga gcaggcccag gtggtaatca      600

ttgatatgaa tgacccaagt aatccaattc gaagaccaat ttcagcagac agcgccatca      660

tgaatccagc tagcaaagta attgcactga aagctgggaa aactcttcag atttttaaca      720

ttgaaatgaa aagtaaaatg aaggctcata ccatgactga tgatgtcacc ttttggaaat      780

ggatctcttt gaatacggtt gctcttgtta cggataatgc agtttatcac tggagtatgg      840

aaggagagtc tcagccagtg aaaatgtttg atcgccattc tagccttgca gggtgccaga      900

ttatcaatta ccgtacagat gcaaaacaaa agtggttact tctgactggt atatctgcac      960

agcaaaatcg tgtggtggga gctatgcagc tatattctgt agataggaaa gtgtctcagc     1020

ccattgaagg acatgcagct agctttgcac agtttaagat ggaaggaaat gcagaagaat     1080

caacgttatt ttgttttgca gttcggggcc aagctggagg gaagttacat attattgaag     1140

ttggcacacc acctacaggg aaccagccct ttccaaagaa ggcagtggat gtcttctttc     1200

ctccagaagc acaaaatgat tttcctgttg caatgcagat cagtgaaaag catgatgtgg     1260

tgttcttgat aaccaagtat ggttatatcc acctctatga tcttgagact ggtacctgca     1320

tctacatgaa tagaatcagt ggagaaacaa tttttgttac tgcacctcat gaagccacag     1380

ctggaataat tggagtaaac agaaagggac aagttctgtc agtgtgtgtg gaagaagaaa     1440

acataattcc ttacatcacc aatgttctac aaaatcctga tttggctctg agaatggctg     1500

tacgtaataa cttagccggt gctgaagaac tctttgcccg gaaatttaat gctctttttg     1560

cccagggaaa ttactcggag gcagcaaagg tggctgctaa tgcaccaaag ggaattcttc     1620

gtactccaga cactatccgt cggttccaga gtgtcccagc ccagccaggt caaacttctc     1680

ctctacttca gtactttggt atccttttgg accagggaca gctcaacaaa tacgaatcct     1740

tagagctttg taggcctgta cttcagcaag ggcgaaaaca gcttttggag aaatggttaa     1800

aagaagataa gctggaatgt tctgaagaac tgggtgatct tgtgaaatct gtggacccta     1860

cattggcact tagtgtgtac ctaagggcta acgtcccaaa taaagtcatt cagtgctttg     1920

cagaaacagg tcaagtccaa aagattgttt tatatgctaa aaaagttgga tacactccag     1980

attggatatt tctgctgaga aatgtaatgc gaatcagtcc agatcaggga cagcagtttg     2040

cccaaatgtt agttcaagat gaagagcctc ttgctgacat cacacagatt gtagatgtct     2100

ttatggaata caatctaatt cagcagtgta ctgcattctt gcttgatgct ctgaagaata     2160

atcgcccatc tgaaggtcct ttacagacgc ggttacttga gatgaacctt atgcatgcgc     2220

ctcaagttgc agatgctatt ctaggcaatc agatgttcac acattatgac cgggctcata     2280

ttgctcaact gtgtgaaaag gctggcctac tgcagcgtgc attagaacat ttcactgatt     2340

tatatgatat aaaacgtgca gtggttcaca cccatcttct taaccctgag tggttagtca     2400

actactttgg ttccttatca gtagaagact ccctagaatg tctcagagcc atgctgtctg     2460

ccaacatccg tcagaatctg cagatttgtg ttcaggtggc ttctaaatat catgaacaac     2520

tgtcaactca gtctctgatt gaactttttg aatctttcaa gagttttgaa ggtctctttt     2580

attttctggg atccattgtt aactttagcc aggacccaga tgtgcacttt aaatatattc     2640

aggcagcttg caagactggg caaatcaaag aagtagaaag aatctgtaga gaaagcaact     2700

gctacgatcc tgagcgagtc aagaattttc ttaaggaagc aaaactaaca gatcagctac     2760

cacttatcat tgtgtgtgat cgatttgact ttgtccatga tttggtgctc tatttatata     2820

gaaataatct tcaaaagtat atagagatat atgtacagaa ggtgaatcca agtcgacttc     2880

ctgtagttat tggaggatta cttgatgttg actgttctga agatgtcata aaaaacttga     2940

ttcttgttgt aagaggtcaa ttctctactg atgagcttgt tgctgaggtt gaaaaaagaa     3000

acagattgaa actgcttctg ccttggctag aggccagaat tcatgagggc tgtgaggagc     3060

ctgctactca caatgcctta gccaaaatct acatagacag taataacaac ccggagagat     3120

ttcttcgtga aaatccctac tatgacagtc gcgttgttgg aaagtattgt gagaagagag     3180

atccacatct ggcctgtgtt gcttatgaac gtggccaatg tgatctggaa cttattaatg     3240

tttgcaatga gaattccctc ttcaaaagtc tttctcgcta cctggtacgt cgaaaggatc     3300

cagaattgtg gggcagcgtg ctgctggaaa gcaatcctta caggagaccc ctaattgacc     3360

aggttgtaca aacagctttg tctgagactc aggaccctga agaagtgtca gtaactgtaa     3420

aggctttcat gactgcagac cttcctaatg aactcattga actgctggag aaaattgtcc     3480

ttgataactc tgtattcagt gaacacagga atctgcaaaa cctccttatc ctcactgcaa     3540

ttaaggctga ccgtacacgt gttatggagt atattaaccg cctggataat tatgatgccc     3600

cagatattgc caatatcgcc atcagcaatg agctgtttga agaagcattt gccattttcc     3660

ggaaatttga tgtcaatact tcagcagttc aggtcttaat tgagcatatt ggaaacttgg     3720

atcgggcata tgagtttgct gaacgttgca atgaacctgc ggtctggagt caacttgcaa     3780

aagcccagtt gcagaaagga atggtgaaag aagccattga ttcttatatc aaagcagatg     3840

atccttcctc ctacatggaa gttgttcagg ctgccaatac tagtggaaac tgggaagaac     3900

tggtgaagta cttgcagatg gcccgtaaga aggctcgaga gtcctatgtg gagacagaac     3960

tgatattcgc actggctaaa acaaaccgcc ttgcagagtt agaagaattt atcaatggac     4020

caaataatgc tcatatccaa caagttggtg accgttgtta tgatgaaaaa atgtatgatg     4080

ctgctaagtt gttgtacaat aatgtttcca attttggacg tttggcatct accctggttc     4140

acctgggtga atatcaggca gctgttgatg gggctaggaa agctaacagt actcgaacat     4200

ggaaagaggt ctgcttcgcc tgtgtagatg ggaaagaatt ccgtcttgct cagatgtgtg     4260

gacttcatat tgttgtacat gcagatgaat tagaagaact tatcaactac tatcaggatc     4320

gtggctattt tgaagagctg atcaccatgt tggaagcagc actgggactt gagcgagctc     4380

acatgggaat gtttactgaa ttagctattc tatactctaa atttaagcct cagaaaatga     4440

gggagcacct ggagctgttc tggtctagag tgaatattcc caaggtgcta agagctgcag     4500

aacaagctca tctttgggca gaactggtgt ttttgtatga caagtatgaa gaatatgata     4560

atgccataat taccatgatg aatcatccaa ctgatgcctg gaaagaaggg caattcaaag     4620

atatcattac caaggttgcc aatgtggaac tatactacag agcaatacag ttctacttag     4680

aattcaagcc tctgttgtta aatgatttgc tgatggtgct gtctccacgg ttggatcaca     4740

ctcgtgcagt caattatttc agcaaggtta aacagctacc actggtgaaa ccgtatttgc     4800

gttcagttca gaaccataac aacaaatctg tgaatgaatc attgaacaat ctttttatta     4860

cagaagaaga ttatcaggct ctgcgaacat caatagatgc ttatgacaac tttgacaata     4920

tctcgcttgc tcagcgtttg gaaaaacatg aactcattga gttcaggaga attgctgctt     4980

atctcttcaa aggcaacaat cgctggaaac agagtgtaga gctgtgcaag aaagacagcc     5040

tttacaagga tgcaatgcag tatgcttctg aatctaaaga tactgaattg gctgaagaac     5100

tcctgcagtg gtttttgcag gaagaaaaaa gagagtgctt tggagcttgt ctgtttacct     5160

gttacgatct tttaaggcca gatgtcgtcc tagaaactgc atggaggcac aatatcatgg     5220

attttgccat gccctatttc atccaggtca tgaaggagta cttgacaaag gtggataaat     5280

tagatgcttc agaatcactg agaaaagaag aagaacaagc tacagagaca caacccattg     5340

tttatggtca gccccagttg atgctgacag caggacccag tgttgccgtc cctccccagg     5400

caccttttgg ttatggttat accgcaccac cgtatggaca gccacagcct ggctttgggt     5460

acagcatgtg agatgaagcg ctgatcctgt agtcacctat tttcgtactg aaacatcgtc     5520

tttacccact tctcagttta taatggggga aaacaggcaa cgtgttcttg taacctttat     5580

ttcatgaagg acttcttttt gtttctaact ataaacttgg atcacctatg ttaaaacctt     5640

atttcacatt ccacatcatt ttagaattta ttttcgaagg ggaatagttt caatgtttta     5700

ttcacttggg ctttttttct tccccctctt tctttaaaga actgctcaat attcaatctg     5760

ttgtgaagaa cctgatttgc actctgtagt gtttaaagaa acaaagaaac tctaatattg     5820

aatctcttaa atttagtgta tgtaaacagc ttacaaatac gtattgtcta aatgcattta     5880

aatctgtttt attcaaagaa aagctaaagc aaaaacactg gcatatgacc atgcaagact     5940

gtcagtgcca acaaagacaa cactaatcag cacatcgtac actggattgc agtgcttccc     6000

agattattga aaaatgttac agacaacttg cctgattttt aaatgagcgt aaaaggccct     6060

ctaacctatg caggtttccc cattatgcat atagaaaatg ctagtatgtt ttgctcactt     6120

catatgtaac aggtgccctt atgttgtgct gtatcctgtg ctttttctgt gggaccattc     6180

cattcaggag caaagagcac catgattcca atcttgtgtg tgtttactaa cccttccctg     6240

aggtttgtgt atgttggata ttgtggtgtt ttagatcact gagtgtacag aagagagaaa     6300

ttcaaacaaa atattgctgt tcttcagttt tgtttgtgga atttgaaatt actcaaattt     6360

aaaataaatt actggactgt ggaaataaca tagaattgaa gttttaatta aataccactc     6420

aaacgaaaag aacagtagtt tttgtagttt tatattggat actgaggcat tagggaggca     6480

tgaaaggaag aggaatgagg attgagacat gtgaagacat tgtgcattat atcaatgtgc     6540

attcctgtag ttcattaaca aggtacatgc aatagtctaa agaaccagag tcactactat     6600

agtggcttaa catttaatct gtctccaata ttttaaccaa gtgacaccga ggtttttatc     6660

gaagcatttc acttaaatga acaaatcatg gctgttatat taacttgaaa taaaatatat     6720

ttaaacatgt agttaacatg ctctttctca tcatgaatta taaaggtgcc caaattatgg     6780

gtatcttgat ttttttcaaa aattggttgt gtgaatccag ctcttgctta tggctgagaa     6840

tgttcctaaa gttcatttca ctatccctta atcctcaata gctacacata cccccttgcc     6900

tagttagtct tgcactgctt tacaactctc ttaggcaaat tacctaacat aagctccaca     6960

gaagagtttt ttaaaactta aaatccctgt cccaccaggt gtggtggctc atgcctgtaa     7020

tcccagcact ttgggaggct gaggcaggcg gattgcttga ggccaggagt tcgagacaag     7080

cctgaccaac atggtgactc catctctact aaaaataaaa aatcagccag gtgtgatggt     7140

ggatgcctat aagatcctag ctgctactca ggaggcagga ggctgaggca tgagaatcac     7200

ttgaacctgt gaggcaaagg ttgtagtgag ccaagatcac gtcactgcac tccatcctgg     7260

gtgacagaat gagactcttg tctcaaaaaa caaaaaaacc tatttagttt catccaggac     7320

attaagtgaa agtgtttaat gtgagtgcag gtcagtgaag aatacaatgg tgcccctgct     7380

ttgatttgtg ggaggtgcca tcagttttcc ccaccactgc ttttgcaccc tcagtgcaaa     7440

tatcaacaca gagaaaaaaa aaataataat agtattatga aaacattgac tctgtggaga     7500

ccctgtgggt tctgcagagt atactttgaa aactataaga ttatgagttc tataaaatac     7560

caagtacaga tgaactagaa aacaagcata tatccacaat taccagaatt ttcatagtat     7620

tccttttagt agatatgcca tgacagttac ttagccaccc catgccatcc tgttgggaat     7680

gccactacct ttgaatttgg agccatcagt ctatctgagg caaacctcag aaattacctg     7740

agccagaatc atgcacttag cactgagttc aactcagtct taacgttgca ttttgttgca     7800

tcacttttgc agccagtaaa cattctgttt agaaatagtt gctattgtgg catcattcac     7860

agttgcaatt tttctcctgt gctgtcatat gcctgtgcga agtgtattaa atgaatcaaa     7920

tattagaaat ttcaaggctg tctttagtgt tctgcccaca atactccacc aatgacctta     7980

gaccttgaga tggtgctata acgctgctta tattgcagtt aaccatagag aggtggagcc     8040

acttaaaatg ggcctattac caaaattctc cctggcatca ttacagttct tggggataca     8100

ctgattttag aaattactgt cagtatcctc ctaaaagaag gcttaaatag tttctaacaa     8160

gatgactatc aggaagctat gtggcttggg gagttgggac cctctgcctc atattctggg     8220

taactggtat aacatagtaa ttattaggat tgtatcaagt gtatctaaag atcaaaaggg     8280

aaaaaaggca cccttaattg tcaaagttag ttctaggaaa aaatactagc agggatgaca     8340

aactacgttc actttacagt taccataaat tcttacttgg gcccacccat ttccatctgt     8400

taaggtccat aaggttactc aagtttcagt ggcttcattg ttacaagaaa ggggggaagt     8460

gagaaacttt aataggctgt gatttagaac cactgctgat taacctttgg ccagtatggg     8520

tcagggaagg tgaacatgaa acactgcaca gtaggttgta tcaatgctat aaaac          8575


<210>  58
<211>  1675
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  59
<211>  1951
<212>  DNA
<213>  Homo sapiens

<400>  59
acctgcaggc ccgggccgcg gggttggttt ccaccctgga ggttgctgac accctgtgcc       60

ctcggctgac ttccagccgg tggcacagac gcctccaggg ggcagcactc aagcgcatct      120

taggaatgac agtaacagcg ggaacatgaa gccgccactc ttggtgttta ttgtgtgtct      180

gctgtggttg aaagacagtc actgcgcacc cacttggaag gacaaaactg ctatcagtga      240

aaacctgaag agtttttctg aggtggggga gatagatgca gatgaagagg tgaagaaggc      300

tttgactggt attaagcaaa tgaaaatcat gatggaaaga aaagagaagg aacacaccaa      360

tctaatgagc accctgaaga aatgcagaga agaaaagcag gaggccctga aacttctgaa      420

tgaagttcaa gaacatctgg aggaagaaga aaggctatgc cgggagtctt tggcagattc      480

ctggggtgaa tgcaggtctt gcctggaaaa taactgcatg agaatttata caacctgcca      540

acctagctgg tcctctgtga aaaataagat tgaacggttt ttcaggaaga tatatcaatt      600

tctatttcct ttccatgaag ataatgaaaa agatctcccc atcagtgaaa agctcattga      660

ggaagatgca caattgaccc aaatggagga tgtgttcagc cagttgactg tggatgtgaa      720

ttctctcttt aacaggagtt ttaacgtctt cagacagatg cagcaagagt ttgaccagac      780

ttttcaatca catttcatat cagatacaga cctaactgag ccttactttt ttccagcttt      840

ctctaaagag ccgatgacaa aagcagatct tgagcaatgt tgggacattc ccaacttctt      900

ccagctgttt tgtaatttca gtgtctctat ttatgaaagt gtcagtgaaa caattactaa      960

gatgctgaag gcaatagaag atttaccaaa acaagacaaa gctcctgacc acggaggcct     1020

gatttcaaag atgttacctg ggcaggacag aggactgtgt ggggaacttg accagaattt     1080

gtcaagatgt ttcaaatttc atgaaaaatg ccaaaaatgt caggctcacc tatctgaaga     1140

ctgtcctgat gtacctgctc tgcacacaga attagacgag gcgatcaggt tggtcaatgt     1200

atccaatcag cagtatggcc agattctcca gatgacccgg aagcacttgg aggacaccgc     1260

ctatctggtg gagaagatga gagggcaatt tggctgggtg tctgaactgg caaaccaggc     1320

cccagaaaca gagatcatct ttaattcaat acaggtagtt ccaaggattc atgaaggaaa     1380

tatttccaaa caagatgaaa caatgatgac agacttaagc attctgcctt cctctaattt     1440

cacactcaag atccctcttg aagaaagtgc tgagagttct aacttcattg gctacgtagt     1500

ggcaaaagct ctacagcatt ttaaggaaca ttttaaaacc tggtaagaag atctaatgca     1560

tcctatatcc agtaagtaga attatctctt catctgggac ctggaaatcc tgaaataaaa     1620

aaggataatg caataaacac agttgcagga aagtatgtta gctatatact atgaagtact     1680

cttagtttac ttatgttgaa tggcttagct attaatactc aaattgagtt aaaatgaaaa     1740

ttcctcctta aaaaatcaaa cgtaatatgt attacatttc atggtacatt agtagttctt     1800

tgtatattga ataaatacta aatcacctag gtgtctatgt tctatcacat ctacaaacat     1860

gtcacttcct aattaacaaa atgttcttcc tttagtttgc ttttgcactt aaaatatata     1920

taattgactt ttttggaaaa aaaaaaaaaa a                                    1951


<210>  60
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys 
1               5                   10                  15      


Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu 
            20                  25                  30          


Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu 
        35                  40                  45              


Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu 
    50                  55                  60                  


Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr Leu Lys Lys Cys 
65                  70                  75                  80  


Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn Glu Val Gln Glu 
                85                  90                  95      


His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser Leu Ala Asp Ser 
            100                 105                 110         


Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys Met Arg Ile Tyr 
        115                 120                 125             


Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn Lys Ile Glu Arg 
    130                 135                 140                 


Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe His Glu Asp Asn 
145                 150                 155                 160 


Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu Glu Asp Ala Gln 
                165                 170                 175     


Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr Val Asp Val Asn 
            180                 185                 190         


Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln Met Gln Gln Glu 
        195                 200                 205             


Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp Thr Asp Leu Thr 
    210                 215                 220                 


Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro Met Thr Lys Ala 
225                 230                 235                 240 


Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe Gln Leu Phe Cys 
                245                 250                 255     


Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu Thr Ile Thr Lys 
            260                 265                 270         


Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp Lys Ala Pro Asp 
        275                 280                 285             


His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln Asp Arg Gly Leu 
    290                 295                 300                 


Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe Lys Phe His Glu 
305                 310                 315                 320 


Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp Cys Pro Asp Val 
                325                 330                 335     


Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg Leu Val Asn Val 
            340                 345                 350         


Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr Arg Lys His Leu 
        355                 360                 365             


Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly Gln Phe Gly Trp 
    370                 375                 380                 


Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu Ile Ile Phe Asn 
385                 390                 395                 400 


Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn Ile Ser Lys Gln 
                405                 410                 415     


Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro Ser Ser Asn Phe 
            420                 425                 430         


Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser Ser Asn Phe Ile 
        435                 440                 445             


Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys Glu His Phe Lys 
    450                 455                 460                 


Thr Trp 
465     


<210>  61
<211>  1877
<212>  DNA
<213>  Homo sapiens

<400>  61
agaaaaacga aggtccttcc agaagctggt ggcaacttca ctggggagat attgcaaata       60

acagcgggaa catgaagccg ccactcttgg tgtttattgt gtgtctgctg tggttgaaag      120

acagtcactg cgcacccact tggaaggaca aaactgctat cagtgaaaac ctgaagagtt      180

tttctgaggt gggggagata gatgcagatg aagaggtgaa gaaggctttg actggtatta      240

agcaaatgaa aatcatgatg gaaagaaaag agaaggaaca caccaatcta atgagcaccc      300

tgaagaaatg cagagaagaa aagcaggagg ccctgaaact tctgaatgaa gttcaagaac      360

atctggagga agaagaaagg ctatgccggg agtctttggc agattcctgg ggtgaatgca      420

ggtcttgcct ggaaaataac tgcatgagaa tttatacaac ctgccaacct agctggtcct      480

ctgtgaaaaa taagattgaa cggtttttca ggaagatata tcaatttcta tttcctttcc      540

atgaagataa tgaaaaagat ctccccatca gtgaaaagct cattgaggaa gatgcacaat      600

tgacccaaat ggaggatgtg ttcagccagt tgactgtgga tgtgaattct ctctttaaca      660

ggagttttaa cgtcttcaga cagatgcagc aagagtttga ccagactttt caatcacatt      720

tcatatcaga tacagaccta actgagcctt acttttttcc agctttctct aaagagccga      780

tgacaaaagc agatcttgag caatgttggg acattcccaa cttcttccag ctgttttgta      840

atttcagtgt ctctatttat gaaagtgtca gtgaaacaat tactaagatg ctgaaggcaa      900

tagaagattt accaaaacaa gacaaagctc ctgaccacgg aggcctgatt tcaaagatgt      960

tacctgggca ggacagagga ctgtgtgggg aacttgacca gaatttgtca agatgtttca     1020

aatttcatga aaaatgccaa aaatgtcagg ctcacctatc tgaagactgt cctgatgtac     1080

ctgctctgca cacagaatta gacgaggcga tcaggttggt caatgtatcc aatcagcagt     1140

atggccagat tctccagatg acccggaagc acttggagga caccgcctat ctggtggaga     1200

agatgagagg gcaatttggc tgggtgtctg aactggcaaa ccaggcccca gaaacagaga     1260

tcatctttaa ttcaatacag gtagttccaa ggattcatga aggaaatatt tccaaacaag     1320

atgaaacaat gatgacagac ttaagcattc tgccttcctc taatttcaca ctcaagatcc     1380

ctcttgaaga aagtgctgag agttctaact tcattggcta cgtagtggca aaagctctac     1440

agcattttaa ggaacatttt aaaacctggt aagaagatct aatgcatcct atatccagta     1500

agtagaatta tctcttcatc tgggacctgg aaatcctgaa ataaaaaagg ataatgcaat     1560

aaacacagtt gcaggaaagt atgttagcta tatactatga agtactctta gtttacttat     1620

gttgaatggc ttagctatta atactcaaat tgagttaaaa tgaaaattcc tccttaaaaa     1680

atcaaacgta atatgtatta catttcatgg tacattagta gttctttgta tattgaataa     1740

atactaaatc acctaggtgt ctatgttcta tcacatctac aaacatgtca cttcctaatt     1800

aacaaaatgt tcttccttta gtttgctttt gcacttaaaa tatatataat tgactttttt     1860

ggaaaaaaaa aaaaaaa                                                    1877


<210>  62
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys 
1               5                   10                  15      


Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu 
            20                  25                  30          


Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu 
        35                  40                  45              


Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu 
    50                  55                  60                  


Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr Leu Lys Lys Cys 
65                  70                  75                  80  


Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn Glu Val Gln Glu 
                85                  90                  95      


His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser Leu Ala Asp Ser 
            100                 105                 110         


Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys Met Arg Ile Tyr 
        115                 120                 125             


Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn Lys Ile Glu Arg 
    130                 135                 140                 


Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe His Glu Asp Asn 
145                 150                 155                 160 


Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu Glu Asp Ala Gln 
                165                 170                 175     


Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr Val Asp Val Asn 
            180                 185                 190         


Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln Met Gln Gln Glu 
        195                 200                 205             


Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp Thr Asp Leu Thr 
    210                 215                 220                 


Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro Met Thr Lys Ala 
225                 230                 235                 240 


Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe Gln Leu Phe Cys 
                245                 250                 255     


Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu Thr Ile Thr Lys 
            260                 265                 270         


Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp Lys Ala Pro Asp 
        275                 280                 285             


His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln Asp Arg Gly Leu 
    290                 295                 300                 


Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe Lys Phe His Glu 
305                 310                 315                 320 


Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp Cys Pro Asp Val 
                325                 330                 335     


Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg Leu Val Asn Val 
            340                 345                 350         


Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr Arg Lys His Leu 
        355                 360                 365             


Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly Gln Phe Gly Trp 
    370                 375                 380                 


Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu Ile Ile Phe Asn 
385                 390                 395                 400 


Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn Ile Ser Lys Gln 
                405                 410                 415     


Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro Ser Ser Asn Phe 
            420                 425                 430         


Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser Ser Asn Phe Ile 
        435                 440                 445             


Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys Glu His Phe Lys 
    450                 455                 460                 


Thr Trp 
465     


<210>  63
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  63
aattcgcctc tgccacaggc tgcaaaggac ccgaggaacc gctctctctg aactgtgctg       60

atgggcagga ggatgggaga caggaattga gagtcacaga ggaaggacag tggagtctgg      120

catcttattg gtgtctttaa aggattgcca tttaatgcca ttcaagatct actaagcatc      180

atttttgcat gactactgca aaaggattac tttacagata ccagttcctt tgtcaagagc      240

atactttgga ccctgttttc agaaagcagg gcactcttta atgaagaaac accagagctg      300

ttaaacacat tgagacacag aagattctag tgactgagga tggcttcctc ttggaaacta      360

atgctgtttc tgtcagtcac catgtgtctt tcagagtatt caaaatctct tcctggtctc      420

tccacttcat atgctgcttt gttaagaatt aagaagagtt catcttcatc tctctttggt      480

tccaaaacca gaccacgata cagcagccct tcattaggaa cactgagtgc ttcttcaccc      540

agctggctag gggcagctca gaattattat tcccccatca atctttatca ttcctcagat      600

gccttcaaac aagatgaaag tgtggactat gggccagttt ttgtgcaaga accagatgat      660

attatttttc caactgattc tgatgaaaag aaggtagcat tgaattgtga agttcgtggc      720

aatccagttc ccagttacag atggcttcga aatggaacag aaatagatct ggaaagtgat      780

tatcgctaca gtttgataga tggcaccttc attataagca atccaagtga agcaaaggat      840

tctggtcatt atcagtgttt agcaaccaac actgtgggga gtattcttag tagagaagct      900

acactgcagt ttgcctatct gggaaatttt agtggccgga caagaagtgc agtctctgtg      960

agggaaggcc agggtgtcgt tctgatgtgc tctcctccgc cacattcacc agagatcatc     1020

tatagctggg tatttaatga gttcccttcc tttgtggcgg aagacagccg gcggttcatc     1080

tcccaggaga caggcaacct ttatatttct aaagtccaaa catcagatgt tggcagctat     1140

atttgtctgg tgaaaaacac agtgacgaat gctagagtcc ttagtcctcc aacgccactc     1200

actctgcgta atgatggtgt gatgggagaa tatgagccga aaattgaggt ccattttcct     1260

ttcacggtta cagctgctaa aggaacaact gttaagatgg aatgctttgc acttggcaac     1320

cccgttccaa caatcacatg gatgaaggtt aatggttata ttcctagtaa ggcacgtctg     1380

cggaaatctc aggcggtgct ggaaataccg aatgtacagc tggatgatgc aggcatttat     1440

gagtgcagag ctgaaaactc acgtggaaaa aattcctttc gtggacaatt acaagtatac     1500

acctacccac actgggtaga aaaactgaat gatactcagt tagacagtgg gagccctctc     1560

cgatgggaat gtaaggctac tggaaaaccc agacccacgt atcgttggct gaagaatgga     1620

gtacccctct cacctcagag tagggttgag atggttaatg gagtattgat gatccacaat     1680

gtgaatcaat cagatgctgg aatgtatcag tgtttggctg aaaataagta tggagccatt     1740

tacgctagtg ctgagctgaa gattctagct tcagctccca cttttgcact gaatcaactg     1800

aagaaaacaa taattgttac caaagaccaa gaagttgtca tagagtgcaa accccaaggc     1860

tctccaaaac caaccatctc ttggaagaaa ggagacagag cagttagaga aaacaaaaga     1920

atagctattc ttccagacgg gagtctacgg atcctaaatg cttccaaatc agacgaggga     1980

aagtacgttt gccgagggga aaacgtcttt ggttctgctg aaattatagc ttcgctatct     2040

gtaaaagaac ctacaaggat agaacttact cctaaaagaa cagaattgac agtgggagaa     2100

agcattgtcc ttaattgcaa agcaattcac gatgctagtt tggatgtcac tttctactgg     2160

actctgaaag gacagcctat tgatttcgag gaagagggtg gacattttga aagcatcagg     2220

gcccaagcat cctctgcaga tttaatgatc aggaacatcc ttctgatgca tgctgggaga     2280

tatggctgca gggtacagac cacagcagac agtgtgtcag atgaggcaga acttcttgtt     2340

aggggacccc caggcccacc tgggatagta attgttgagg aaataaccga aagtacggcc     2400

acactgtcct ggagcccagc agctgacaac cacagcccaa tctcctccta caaccttcaa     2460

gctcgcagcc cattttccct gggctggcaa acagtaaaga cagtcccaga aatcataaca     2520

ggggacatgg agtcagccat ggctgtggac ctaaatccct gggtggaata tgaatttcga     2580

gtggtagcca ccaaccctat tgggacagga gatccaagca ccccatctcg aatgatccgc     2640

acaaatgaag cagttccgaa gacagcaccc accaatgtaa gcggaagaag tggaagaagg     2700

catgagttag tcattgcctg ggagccagta tctgaagagt ttcagaatgg ggaaggcttc     2760

ggctatattg tggctttcag acccaatgga acacgtggct ggaaggaaaa aatggtgaca     2820

tcctctgaag cttccaaatt catttatcga gatgaaagtg tccctcctct tactcccttt     2880

gaagtgaaag ttggcgttta taacaataaa ggagatgggc cttttagtca aattgtggtc     2940

atctgttcag ctgaaggaga acccagtgct gctcccacag atgtcaaggc gacaagtgtg     3000

tctgtgtcag agattcttgt tgcatggaaa cacattaaag agagtctagg aagaccacag     3060

ggatttgagg ttggttactg gaaagacatg gaacaggaag atacagcaga aacagtcaaa     3120

actagaggga atgagtcttt cgtcatccta acaggattag aaggaaatac gttatatcac     3180

ttcacagtga gggcttacaa tggagctgga tatgggccac ctagcagtga agtgagtgca     3240

accaccaaga aatcccctcc tagtcaagca cctagcaacc tcaggtggga gcagcaaggc     3300

tctcaggttt ctctgggctg ggaacccgtc ataccattag ccaacgaatc tgaagttgtg     3360

ggttacaagg ttttttatag gcaagagggt cacagcaaca gccaagttat tgaaacacag     3420

aaacttcaag cagtagtacc actcccagat gctggagtct atattattga agttcgagca     3480

tatagtgaag gaggagatgg aacagctagt tctcaaatta gggtaccatc atattcaggt     3540

ggaaaaatca caagtgcaca gtcgaccctt cactctctct ccacatcttc gtcatcagtc     3600

accttgctct tggcattgat gattccttca acttcctggt gaaaactgct gacttaattt     3660

gcttttgttt gctttagctt ggtaacagcg gtgaatagag tgtagtgtaa gtggagaacc     3720

aggatcctga gatgagcttg agctttaaaa acttgggact atacatggtg aacttacagg     3780

aggttagggg ggaaatatta cttatccatc aggtttctct ttggtttttg taaacggaga     3840

ggacagttct tagtccagta aaaatatgca gattgtatgt aatgaatttt tgtaaacaaa     3900

ggtaatttct gtcaaatgta ttctttactt ttttaatatg ttgggatttt attttatatc     3960

tgatgactcc gagtgtgtgc catccatttg ttaagtaact ggcctttagc agatctgttt     4020

caaaaacaaa tacaaaaatg agaatgaaaa gtttgcttaa gactaagtcc agtgtttttc     4080

attttccctt tggctgaata tttcaattga caaaccagca ggacatatga aaaatgcttc     4140

agtgatgtgg tccattataa gata                                            4164


<210>  64
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
            900                 905                 910         


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
        915                 920                 925             


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
    930                 935                 940                 


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
945                 950                 955                 960 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
                965                 970                 975     


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
            980                 985                 990         


Gly Trp Glu Pro Val Ile Pro Leu  Ala Asn Glu Ser Glu  Val Val Gly 
        995                 1000                 1005             


Tyr Lys  Val Phe Tyr Arg Gln  Glu Gly His Ser Asn  Ser Gln Val 
    1010                 1015                 1020             


Ile Glu  Thr Gln Lys Leu Gln  Ala Val Val Pro Leu  Pro Asp Ala 
    1025                 1030                 1035             


Gly Val  Tyr Ile Ile Glu Val  Arg Ala Tyr Ser Glu  Gly Gly Asp 
    1040                 1045                 1050             


Gly Thr  Ala Ser Ser Gln Ile  Arg Val Pro Ser Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Lys Ile  Thr Ser Ala Gln Ser  Thr Leu His Ser Leu  Ser Thr Ser 
    1070                 1075                 1080             


Ser Ser  Ser Val Thr Leu Leu  Leu Ala Leu Met Ile  Pro Ser Thr 
    1085                 1090                 1095             


Ser Trp  
    1100 


<210>  65
<211>  3942
<212>  DNA
<213>  Homo sapiens

<400>  65
aattcgcctc tgccacaggc tgcaaaggac ccgaggaacc gctctctctg aactgtgctg       60

atgggcagga ggatgggaga caggaattga gagtcacaga ggaaggacag tggagtctgg      120

catcttattg gtgtctttaa aggattgcca tttaatgcca ttcaagatct actaagcatc      180

atttttgcat gactactgca aaaggattac tttacagata ccagttcctt tgtcaagagc      240

atactttgga ccctgttttc agaaagcagg gcactcttta atgaagaaac accagagctg      300

ttaaacacat tgagacacag aagattctag tgactgagga tggcttcctc ttggaaacta      360

atgctgtttc tgtcagtcac catgtgtctt tcagaaagtg tggactatgg gccagttttt      420

gtgcaagaac cagatgatat tatttttcca actgattctg atgaaaagaa ggtagcattg      480

aattgtgaag ttcgtggcaa tccagttccc agttacagat ggcttcgaaa tggaacagaa      540

atagatctgg aaagtgatta tcgctacagt ttgatagatg gcaccttcat tataagcaat      600

ccaagtgaag caaaggattc tggtcattat cagtgtttag caaccaacac tgtggggagt      660

attcttagta gagaagctac actgcagttt gcctatctgg gaaattttag tggccggaca      720

agaagtgcag tctctgtgag ggaaggccag ggtgtcgttc tgatgtgctc tcctccgcca      780

cattcaccag agatcatcta tagctgggta tttaatgagt tcccttcctt tgtggcggaa      840

gacagccggc ggttcatctc ccaggagaca ggcaaccttt atatttctaa agtccaaaca      900

tcagatgttg gcagctatat ttgtctggtg aaaaacacag tgacgaatgc tagagtcctt      960

agtcctccaa cgccactcac tctgcgtaat gatggtgtga tgggagaata tgagccgaaa     1020

attgaggtcc attttccttt cacggttaca gctgctaaag gaacaactgt taagatggaa     1080

tgctttgcac ttggcaaccc cgttccaaca atcacatgga tgaaggttaa tggttatatt     1140

cctagtaagg cacgtctgcg gaaatctcag gcggtgctgg aaataccgaa tgtacagctg     1200

gatgatgcag gcatttatga gtgcagagct gaaaactcac gtggaaaaaa ttcctttcgt     1260

ggacaattac aagtatacac ctacccacac tgggtagaaa aactgaatga tactcagtta     1320

gacagtggga gccctctccg atgggaatgt aaggctactg gaaaacccag acccacgtat     1380

cgttggctga agaatggagt acccctctca cctcagagta gggttgagat ggttaatgga     1440

gtattgatga tccacaatgt gaatcaatca gatgctggaa tgtatcagtg tttggctgaa     1500

aataagtatg gagccattta cgctagtgct gagctgaaga ttctagcttc agctcccact     1560

tttgcactga atcaactgaa gaaaacaata attgttacca aagaccaaga agttgtcata     1620

gagtgcaaac cccaaggctc tccaaaacca accatctctt ggaagaaagg agacagagca     1680

gttagagaaa acaaaagaat agctattctt ccagacggga gtctacggat cctaaatgct     1740

tccaaatcag acgagggaaa gtacgtttgc cgaggggaaa acgtctttgg ttctgctgaa     1800

attatagctt cgctatctgt aaaagaacct acaaggatag aacttactcc taaaagaaca     1860

gaattgacag tgggagaaag cattgtcctt aattgcaaag caattcacga tgctagtttg     1920

gatgtcactt tctactggac tctgaaagga cagcctattg atttcgagga agagggtgga     1980

cattttgaaa gcatcagggc ccaagcatcc tctgcagatt taatgatcag gaacatcctt     2040

ctgatgcatg ctgggagata tggctgcagg gtacagacca cagcagacag tgtgtcagat     2100

gaggcagaac ttcttgttag gggaccccca ggcccacctg ggatagtaat tgttgaggaa     2160

ataaccgaaa gtacggccac actgtcctgg agcccagcag ctgacaacca cagcccaatc     2220

tcctcctaca accttcaagc tcgcagccca ttttccctgg gctggcaaac agtaaagaca     2280

gtcccagaaa tcataacagg ggacatggag tcagccatgg ctgtggacct aaatccctgg     2340

gtggaatatg aatttcgagt ggtagccacc aaccctattg ggacaggaga tccaagcacc     2400

ccatctcgaa tgatccgcac aaatgaagca gttccgaaga cagcacccac caatgtaagc     2460

ggaagaagtg gaagaaggca tgagttagtc attgcctggg agccagtatc tgaagagttt     2520

cagaatgggg aaggcttcgg ctatattgtg gctttcagac ccaatggaac acgtggctgg     2580

aaggaaaaaa tggtgacatc ctctgaagct tccaaattca tttatcgaga tgaaagtgtc     2640

cctcctctta ctccctttga agtgaaagtt ggcgtttata acaataaagg agatgggcct     2700

tttagtcaaa ttgtggtcat ctgttcagct gaaggagaac ccagtgctgc tcccacagat     2760

gtcaaggcga caagtgtgtc tgtgtcagag attcttgttg catggaaaca cattaaagag     2820

agtctaggaa gaccacaggg atttgaggtt ggttactgga aagacatgga acaggaagat     2880

acagcagaaa cagtcaaaac tagagggaat gagtctttcg tcatcctaac aggattagaa     2940

ggaaatacgt tatatcactt cacagtgagg gcttacaatg gagctggata tgggccacct     3000

agcagtgaag tgagtgcaac caccaagaaa tcccctccta gtcaagcacc tagcaacctc     3060

aggtgggagc agcaaggctc tcaggtttct ctgggctggg aacccgtcat accattagcc     3120

aacgaatctg aagttgtggg ttacaaggtt ttttataggc aagagggtca cagcaacagc     3180

caagttattg aaacacagaa acttcaagca gtagtaccac tcccagatgc tggagtctat     3240

attattgaag ttcgagcata tagtgaagga ggagatggaa cagctagttc tcaaattagg     3300

gtaccatcat attcaggtgg aaaaatcaca agtgcacagt cgacccttca ctctctctcc     3360

acatcttcgt catcagtcac cttgctcttg gcattgatga ttccttcaac ttcctggtga     3420

aaactgctga cttaatttgc ttttgtttgc tttagcttgg taacagcggt gaatagagtg     3480

tagtgtaagt ggagaaccag gatcctgaga tgagcttgag ctttaaaaac ttgggactat     3540

acatggtgaa cttacaggag gttagggggg aaatattact tatccatcag gtttctcttt     3600

ggtttttgta aacggagagg acagttctta gtccagtaaa aatatgcaga ttgtatgtaa     3660

tgaatttttg taaacaaagg taatttctgt caaatgtatt ctttactttt ttaatatgtt     3720

gggattttat tttatatctg atgactccga gtgtgtgcca tccatttgtt aagtaactgg     3780

cctttagcag atctgtttca aaaacaaata caaaaatgag aatgaaaagt ttgcttaaga     3840

ctaagtccag tgtttttcat tttccctttg gctgaatatt tcaattgaca aaccagcagg     3900

acatatgaaa aatgcttcag tgatgtggtc cattataaga ta                        3942


<210>  66
<211>  1026
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Ser Val Asp Tyr Gly Pro Val Phe Val Gln Glu Pro Asp 
            20                  25                  30          


Asp Ile Ile Phe Pro Thr Asp Ser Asp Glu Lys Lys Val Ala Leu Asn 
        35                  40                  45              


Cys Glu Val Arg Gly Asn Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn 
    50                  55                  60                  


Gly Thr Glu Ile Asp Leu Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp 
65                  70                  75                  80  


Gly Thr Phe Ile Ile Ser Asn Pro Ser Glu Ala Lys Asp Ser Gly His 
                85                  90                  95      


Tyr Gln Cys Leu Ala Thr Asn Thr Val Gly Ser Ile Leu Ser Arg Glu 
            100                 105                 110         


Ala Thr Leu Gln Phe Ala Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg 
        115                 120                 125             


Ser Ala Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Met Cys Ser 
    130                 135                 140                 


Pro Pro Pro His Ser Pro Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu 
145                 150                 155                 160 


Phe Pro Ser Phe Val Ala Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu 
                165                 170                 175     


Thr Gly Asn Leu Tyr Ile Ser Lys Val Gln Thr Ser Asp Val Gly Ser 
            180                 185                 190         


Tyr Ile Cys Leu Val Lys Asn Thr Val Thr Asn Ala Arg Val Leu Ser 
        195                 200                 205             


Pro Pro Thr Pro Leu Thr Leu Arg Asn Asp Gly Val Met Gly Glu Tyr 
    210                 215                 220                 


Glu Pro Lys Ile Glu Val His Phe Pro Phe Thr Val Thr Ala Ala Lys 
225                 230                 235                 240 


Gly Thr Thr Val Lys Met Glu Cys Phe Ala Leu Gly Asn Pro Val Pro 
                245                 250                 255     


Thr Ile Thr Trp Met Lys Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg 
            260                 265                 270         


Leu Arg Lys Ser Gln Ala Val Leu Glu Ile Pro Asn Val Gln Leu Asp 
        275                 280                 285             


Asp Ala Gly Ile Tyr Glu Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Ser Phe Arg Gly Gln Leu Gln Val Tyr Thr Tyr Pro His Trp Val Glu 
305                 310                 315                 320 


Lys Leu Asn Asp Thr Gln Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu 
                325                 330                 335     


Cys Lys Ala Thr Gly Lys Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn 
            340                 345                 350         


Gly Val Pro Leu Ser Pro Gln Ser Arg Val Glu Met Val Asn Gly Val 
        355                 360                 365             


Leu Met Ile His Asn Val Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys Tyr Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys 
385                 390                 395                 400 


Ile Leu Ala Ser Ala Pro Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr 
                405                 410                 415     


Ile Ile Val Thr Lys Asp Gln Glu Val Val Ile Glu Cys Lys Pro Gln 
            420                 425                 430         


Gly Ser Pro Lys Pro Thr Ile Ser Trp Lys Lys Gly Asp Arg Ala Val 
        435                 440                 445             


Arg Glu Asn Lys Arg Ile Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile 
    450                 455                 460                 


Leu Asn Ala Ser Lys Ser Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu 
465                 470                 475                 480 


Asn Val Phe Gly Ser Ala Glu Ile Ile Ala Ser Leu Ser Val Lys Glu 
                485                 490                 495     


Pro Thr Arg Ile Glu Leu Thr Pro Lys Arg Thr Glu Leu Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Asn Cys Lys Ala Ile His Asp Ala Ser Leu Asp 
        515                 520                 525             


Val Thr Phe Tyr Trp Thr Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu 
    530                 535                 540                 


Glu Gly Gly His Phe Glu Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Leu Leu Met His Ala Gly Arg Tyr Gly Cys 
                565                 570                 575     


Arg Val Gln Thr Thr Ala Asp Ser Val Ser Asp Glu Ala Glu Leu Leu 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Val Glu Glu Ile 
        595                 600                 605             


Thr Glu Ser Thr Ala Thr Leu Ser Trp Ser Pro Ala Ala Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Ser Ser Tyr Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu 
625                 630                 635                 640 


Gly Trp Gln Thr Val Lys Thr Val Pro Glu Ile Ile Thr Gly Asp Met 
                645                 650                 655     


Glu Ser Ala Met Ala Val Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Val Val Ala Thr Asn Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro 
        675                 680                 685             


Ser Arg Met Ile Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr 
    690                 695                 700                 


Asn Val Ser Gly Arg Ser Gly Arg Arg His Glu Leu Val Ile Ala Trp 
705                 710                 715                 720 


Glu Pro Val Ser Glu Glu Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile 
                725                 730                 735     


Val Ala Phe Arg Pro Asn Gly Thr Arg Gly Trp Lys Glu Lys Met Val 
            740                 745                 750         


Thr Ser Ser Glu Ala Ser Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro 
        755                 760                 765             


Pro Leu Thr Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly 
    770                 775                 780                 


Asp Gly Pro Phe Ser Gln Ile Val Val Ile Cys Ser Ala Glu Gly Glu 
785                 790                 795                 800 


Pro Ser Ala Ala Pro Thr Asp Val Lys Ala Thr Ser Val Ser Val Ser 
                805                 810                 815     


Glu Ile Leu Val Ala Trp Lys His Ile Lys Glu Ser Leu Gly Arg Pro 
            820                 825                 830         


Gln Gly Phe Glu Val Gly Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr 
        835                 840                 845             


Ala Glu Thr Val Lys Thr Arg Gly Asn Glu Ser Phe Val Ile Leu Thr 
    850                 855                 860                 


Gly Leu Glu Gly Asn Thr Leu Tyr His Phe Thr Val Arg Ala Tyr Asn 
865                 870                 875                 880 


Gly Ala Gly Tyr Gly Pro Pro Ser Ser Glu Val Ser Ala Thr Thr Lys 
                885                 890                 895     


Lys Ser Pro Pro Ser Gln Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln 
            900                 905                 910         


Gly Ser Gln Val Ser Leu Gly Trp Glu Pro Val Ile Pro Leu Ala Asn 
        915                 920                 925             


Glu Ser Glu Val Val Gly Tyr Lys Val Phe Tyr Arg Gln Glu Gly His 
    930                 935                 940                 


Ser Asn Ser Gln Val Ile Glu Thr Gln Lys Leu Gln Ala Val Val Pro 
945                 950                 955                 960 


Leu Pro Asp Ala Gly Val Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu 
                965                 970                 975     


Gly Gly Asp Gly Thr Ala Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser 
            980                 985                 990         


Gly Gly Lys Ile Thr Ser Ala Gln  Ser Thr Leu His Ser  Leu Ser Thr 
        995                 1000                 1005             


Ser Ser  Ser Ser Val Thr Leu  Leu Leu Ala Leu Met  Ile Pro Ser 
    1010                 1015                 1020             


Thr Ser  Trp 
    1025     


<210>  67
<211>  2317
<212>  DNA
<213>  Homo sapiens

<400>  67
agtaggatgc ggccagcgca ggagctggtg gtgaaaaact gatctcgcat gttcagaaac       60

tgcacaagct ctaccacatc ctcgtcaaca ctgcccttcc ggctgaggtc cgctttgctc      120

aaacattgcg ccttccattt cctgaactcc gcgctgcgat ccatgggtga cggactcagg      180

gtctgcgctc ggctccttca tggtagcctc gtctctccct gggggcagcc atattgaagc      240

gagcggtggc cgaaaaggtc caaacttcct cttcgttctt aatttgggaa attctagtgc      300

cttcgcctag gggtggagag aggcgcacat cctgggtgga gcgaggcgca catcctgggt      360

ggagcctgca aaagttggag aaggtgtggc agtcctcatt tctgtggaat ctgaagaagc      420

ccacgcagat tttaattccc actctagatt ctggcttcat cgttatgaag catatgatga      480

tcccgtggat agtatctaga tcaccatggc gactggacag aagttgatga gagctgttag      540

agtttttgaa tttggtgggc cagaagtcct gaaattgcga tcagatattg cagtaccgat      600

tccaaaagac catcaggttc taatcaaggt ccatgcatgt ggtgtcaacc ccgtggagac      660

atacattcgc tctggtactt atagtagaaa accactctta ccctatactc ctggctcaga      720

tgtggctggg gtgatagaag ctgttggaga taatgcatct gctttcaaga aaggtgacag      780

agttttcact agcagcacga tctctggggg ttatgcagag tatgctcttg cagcagacca      840

cactgtttac aaactacctg aaaaactgga ctttaaacaa ggagctgcca tcggcattcc      900

atattttact gcttatcgag ctctgatcca cagtgcctgt gtgaaagctg gagagagtgt      960

tctggttcat ggggcaagtg gaggagttgg attagcagca tgccaaattg ctagagctta     1020

tggcttaaag attttgggca ctgctggtac tgaggaagga caaaagattg ttttgcaaaa     1080

tggagcccat gaagtgttca atcacagaga agtgaattac attgataaaa ttaagaagta     1140

tgttggtgag aaaggaattg atataattat tgaaatgtta gctaatgtaa atcttagtaa     1200

agacttgagt cttctgtcac atggaggacg agtgatagtt gttggcagca gaggtactat     1260

tgaaataaac ccacgagaca ccatggcaaa ggagtcgagt ataattggag ttactctctt     1320

ttcctcaacc aaggaggaat ttcagcaata tgcagcagcc cttcaagctg gaatggaaat     1380

tggctggttg aaacctgtga taggttctca atatccattg gagaaggtgg ccgaggctca     1440

tgaaaatatc attcatggta gtggggctac tggaaaaatg attcttctct tatgatgatt     1500

aattctttca tggatttcct atgtaattag aggtactgtc tttcccccag ttgtacttac     1560

cctatctttt ctttaattaa cattcgattc catgagcttc ttatgtgaaa aaataagatt     1620

tttctttaga gagcagaagc agaagagtaa aatttattgt atagctagca atattttttt     1680

atgccatctg tctcaaatca aagagtcatc atagtaggaa ataacatgtt agttgtcatt     1740

tggcatgagt gtgcattcca gtaattctta attgatattt gattaattcc atacctttga     1800

ttaaaacatg ctagttcaaa ataagactgc tcagtttcca agggttttca agcctactta     1860

cctttataaa ggttctctag tctctgatta gccatgactg tattggactt tgaacatttt     1920

ctgaactaaa aacctctatt ctaaactaat ctcatttgga tgtgtaagtc ttttgtaaag     1980

gcaagaataa ataatatcca ggacaattta ttagttttct cagtattttc ccaaatatta     2040

gaatatttac ttcattattg gttggctgcc aatgacccca tatgttctgt gagaatagta     2100

gctttatctt tgatataata catagtctcc aaataggtaa tacttcgcaa ttgattagat     2160

tttcagagta gatttagagt tatctgtttt tctggtgagg gtcaaatatt tttgttaatt     2220

aagctcacaa atttgataaa ttaagaatta tctgcatttg tctcgtaaca taataatgtg     2280

taataaagtc tatagaaaat taaaaaaaaa aaaaaaa                              2317


<210>  68
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Thr Gly Gln Lys Leu Met Arg Ala Val Arg Val Phe Glu Phe 
1               5                   10                  15      


Gly Gly Pro Glu Val Leu Lys Leu Arg Ser Asp Ile Ala Val Pro Ile 
            20                  25                  30          


Pro Lys Asp His Gln Val Leu Ile Lys Val His Ala Cys Gly Val Asn 
        35                  40                  45              


Pro Val Glu Thr Tyr Ile Arg Ser Gly Thr Tyr Ser Arg Lys Pro Leu 
    50                  55                  60                  


Leu Pro Tyr Thr Pro Gly Ser Asp Val Ala Gly Val Ile Glu Ala Val 
65                  70                  75                  80  


Gly Asp Asn Ala Ser Ala Phe Lys Lys Gly Asp Arg Val Phe Thr Ser 
                85                  90                  95      


Ser Thr Ile Ser Gly Gly Tyr Ala Glu Tyr Ala Leu Ala Ala Asp His 
            100                 105                 110         


Thr Val Tyr Lys Leu Pro Glu Lys Leu Asp Phe Lys Gln Gly Ala Ala 
        115                 120                 125             


Ile Gly Ile Pro Tyr Phe Thr Ala Tyr Arg Ala Leu Ile His Ser Ala 
    130                 135                 140                 


Cys Val Lys Ala Gly Glu Ser Val Leu Val His Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Val Gly Leu Ala Ala Cys Gln Ile Ala Arg Ala Tyr Gly Leu Lys Ile 
                165                 170                 175     


Leu Gly Thr Ala Gly Thr Glu Glu Gly Gln Lys Ile Val Leu Gln Asn 
            180                 185                 190         


Gly Ala His Glu Val Phe Asn His Arg Glu Val Asn Tyr Ile Asp Lys 
        195                 200                 205             


Ile Lys Lys Tyr Val Gly Glu Lys Gly Ile Asp Ile Ile Ile Glu Met 
    210                 215                 220                 


Leu Ala Asn Val Asn Leu Ser Lys Asp Leu Ser Leu Leu Ser His Gly 
225                 230                 235                 240 


Gly Arg Val Ile Val Val Gly Ser Arg Gly Thr Ile Glu Ile Asn Pro 
                245                 250                 255     


Arg Asp Thr Met Ala Lys Glu Ser Ser Ile Ile Gly Val Thr Leu Phe 
            260                 265                 270         


Ser Ser Thr Lys Glu Glu Phe Gln Gln Tyr Ala Ala Ala Leu Gln Ala 
        275                 280                 285             


Gly Met Glu Ile Gly Trp Leu Lys Pro Val Ile Gly Ser Gln Tyr Pro 
    290                 295                 300                 


Leu Glu Lys Val Ala Glu Ala His Glu Asn Ile Ile His Gly Ser Gly 
305                 310                 315                 320 


Ala Thr Gly Lys Met Ile Leu Leu Leu 
                325                 


<210>  69
<211>  2176
<212>  DNA
<213>  Homo sapiens

<400>  69
agtaggatgc ggccagcgca ggagctggtg gtgaaaaact gatctcgcat gttcagaaac       60

tgcacaagct ctaccacatc ctcgtcaaca ctgcccttcc ggctgaggtc cgctttgctc      120

aaacattgcg ccttccattt cctgaactcc gcgctgcgat ccatgggtga cggactcagg      180

gtctgcgctc ggctccttca tggtagcctc gtctctccct gggggcagcc atattgaagc      240

gagcggtggc cgaaaaggtc caaacttcct cttcgttctt aatttgggaa attctagtgc      300

cttcgcctag gggtggagag aggcgcacat cctgggtgga gcgaggcgca catcctgggt      360

ggagcctgca aaagttggag aaggtgtggc agtcctcatt tctgtggaat ctgaagaagc      420

ccacgcagat tttaattccc actctagatt ctgtatctag atcaccatgg cgactggaca      480

gaagttgatg agagctgtta gagtttttga atttggtggg ccagaagtcc tgaaattgcg      540

atcagatatt gcagtaccga ttccaaaaga ccatcaggtt ctaatcaagg tccatgcatg      600

tggtgtcaac cccgtggaga catacattcg ctctggtact tatagtagaa aaccactctt      660

accctatact cctggctcag atgtggctgg ggtgatagaa gctgttggag ataatgcatc      720

tgctttcaag aaaggtgaca gagttttcac tagcagcacg atctctgggg gttatgcaga      780

gtatgctctt gcagcagacc acactgttta caaactacct gaaaaactgg actttaaaca      840

aggagctgcc atcggcattc catattttac tgcttatcga gctctgatcc acagtgcctg      900

tgtgaaagct ggagagagtg ttctggttca tggggcaagt ggaggagttg gattagcagc      960

atgccaaatt gctagagctt atggcttaaa gattttgggc actgctggta ctgaggaagg     1020

acaaaagatt gttttgcaaa atggagccca tgaagtgttc aatcacagag aagtgaatta     1080

cattgataaa attaaggttg ttggcagcag aggtactatt gaaataaacc cacgagacac     1140

catggcaaag gagtcgagta taattggagt tactctcttt tcctcaacca aggaggaatt     1200

tcagcaatat gcagcagccc ttcaagctgg aatggaaatt ggctggttga aacctgtgat     1260

aggttctcaa tatccattgg agaaggtggc cgaggctcat gaaaatatca ttcatggtag     1320

tggggctact ggaaaaatga ttcttctctt atgatgatta attctttcat ggatttccta     1380

tgtaattaga ggtactgtct ttcccccagt tgtacttacc ctatcttttc tttaattaac     1440

attcgattcc atgagcttct tatgtgaaaa aataagattt ttctttagag agcagaagca     1500

gaagagtaaa atttattgta tagctagcaa tattttttta tgccatctgt ctcaaatcaa     1560

agagtcatca tagtaggaaa taacatgtta gttgtcattt ggcatgagtg tgcattccag     1620

taattcttaa ttgatatttg attaattcca tacctttgat taaaacatgc tagttcaaaa     1680

taagactgct cagtttccaa gggttttcaa gcctacttac ctttataaag gttctctagt     1740

ctctgattag ccatgactgt attggacttt gaacattttc tgaactaaaa acctctattc     1800

taaactaatc tcatttggat gtgtaagtct tttgtaaagg caagaataaa taatatccag     1860

gacaatttat tagttttctc agtattttcc caaatattag aatatttact tcattattgg     1920

ttggctgcca atgaccccat atgttctgtg agaatagtag ctttatcttt gatataatac     1980

atagtctcca aataggtaat acttcgcaat tgattagatt ttcagagtag atttagagtt     2040

atctgttttt ctggtgaggg tcaaatattt ttgttaatta agctcacaaa tttgataaat     2100

taagaattat ctgcatttgt ctcgtaacat aataatgtgt aataaagtct atagaaaatt     2160

aaaaaaaaaa aaaaaa                                                     2176


<210>  70
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Thr Gly Gln Lys Leu Met Arg Ala Val Arg Val Phe Glu Phe 
1               5                   10                  15      


Gly Gly Pro Glu Val Leu Lys Leu Arg Ser Asp Ile Ala Val Pro Ile 
            20                  25                  30          


Pro Lys Asp His Gln Val Leu Ile Lys Val His Ala Cys Gly Val Asn 
        35                  40                  45              


Pro Val Glu Thr Tyr Ile Arg Ser Gly Thr Tyr Ser Arg Lys Pro Leu 
    50                  55                  60                  


Leu Pro Tyr Thr Pro Gly Ser Asp Val Ala Gly Val Ile Glu Ala Val 
65                  70                  75                  80  


Gly Asp Asn Ala Ser Ala Phe Lys Lys Gly Asp Arg Val Phe Thr Ser 
                85                  90                  95      


Ser Thr Ile Ser Gly Gly Tyr Ala Glu Tyr Ala Leu Ala Ala Asp His 
            100                 105                 110         


Thr Val Tyr Lys Leu Pro Glu Lys Leu Asp Phe Lys Gln Gly Ala Ala 
        115                 120                 125             


Ile Gly Ile Pro Tyr Phe Thr Ala Tyr Arg Ala Leu Ile His Ser Ala 
    130                 135                 140                 


Cys Val Lys Ala Gly Glu Ser Val Leu Val His Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Val Gly Leu Ala Ala Cys Gln Ile Ala Arg Ala Tyr Gly Leu Lys Ile 
                165                 170                 175     


Leu Gly Thr Ala Gly Thr Glu Glu Gly Gln Lys Ile Val Leu Gln Asn 
            180                 185                 190         


Gly Ala His Glu Val Phe Asn His Arg Glu Val Asn Tyr Ile Asp Lys 
        195                 200                 205             


Ile Lys Val Val Gly Ser Arg Gly Thr Ile Glu Ile Asn Pro Arg Asp 
    210                 215                 220                 


Thr Met Ala Lys Glu Ser Ser Ile Ile Gly Val Thr Leu Phe Ser Ser 
225                 230                 235                 240 


Thr Lys Glu Glu Phe Gln Gln Tyr Ala Ala Ala Leu Gln Ala Gly Met 
                245                 250                 255     


Glu Ile Gly Trp Leu Lys Pro Val Ile Gly Ser Gln Tyr Pro Leu Glu 
            260                 265                 270         


Lys Val Ala Glu Ala His Glu Asn Ile Ile His Gly Ser Gly Ala Thr 
        275                 280                 285             


Gly Lys Met Ile Leu Leu Leu 
    290                 295 


<210>  71
<211>  1990
<212>  DNA
<213>  Homo sapiens

<400>  71
agtaggatgc ggccagcgca ggagctggtg gtgaaaaact gatctcgcat gttcagaaac       60

tgcacaagct ctaccacatc ctcgtcaaca ctgcccttcc ggctgaggtc cgctttgctc      120

aaacattgcg ccttccattt cctgaactcc gcgctgcgat ccatgggtga cggactcagg      180

gtctgcgctc ggctccttca tggtagcctc gtctctccct gggggcagcc atattgaagc      240

gagcggtggc cgaaaaggtc caaacttcct cttcgttctt aatttgggaa attctagtgc      300

cttcgcctag gggtggagag aggcgcacat cctgggtgga gcgaggcgca catcctgggt      360

ggagcctgca aaagttggag aaggtgtggc agtcctcatt tctgtggaat ctgaagaagc      420

ccacgcagat tttaattccc actctagatt ctggttctaa tcaaggtcca tgcatgtggt      480

gtcaaccccg tggagacata cattcgctct ggtacttata gtagaaaacc actcttaccc      540

tatactcctg gctcagatgt ggctggggtg atagaagctg ttggagataa tgcatctgct      600

ttcaagtgcc tgtgtgaaag ctggagagag tgttctggtt catggggcaa gtggaggagt      660

tggattagca gcatgccaaa ttgctagagc ttatggctta aagattttgg gcactgctgg      720

tactgaggaa ggacaaaaga ttgttttgca aaatggagcc catgaagtgt tcaatcacag      780

agaagtgaat tacattgata aaattaagaa gtatgttggt gagaaaggaa ttgatataat      840

tattgaaatg ttagctaatg taaatcttag taaagacttg agtcttctgt cacatggagg      900

acgagtgata gttgttggca gcagaggtac tattgaaata aacccacgag acaccatggc      960

aaaggagtcg agtataattg gagttactct cttttcctca accaaggagg aatttcagca     1020

atatgcagca gcccttcaag ctggaatgga aattggctgg ttgaaacctg tgataggttc     1080

tcaatatcca ttggagaagg tggccgaggc tcatgaaaat atcattcatg gtagtggggc     1140

tactggaaaa atgattcttc tcttatgatg attaattctt tcatggattt cctatgtaat     1200

tagaggtact gtctttcccc cagttgtact taccctatct tttctttaat taacattcga     1260

ttccatgagc ttcttatgtg aaaaaataag atttttcttt agagagcaga agcagaagag     1320

taaaatttat tgtatagcta gcaatatttt tttatgccat ctgtctcaaa tcaaagagtc     1380

atcatagtag gaaataacat gttagttgtc atttggcatg agtgtgcatt ccagtaattc     1440

ttaattgata tttgattaat tccatacctt tgattaaaac atgctagttc aaaataagac     1500

tgctcagttt ccaagggttt tcaagcctac ttacctttat aaaggttctc tagtctctga     1560

ttagccatga ctgtattgga ctttgaacat tttctgaact aaaaacctct attctaaact     1620

aatctcattt ggatgtgtaa gtcttttgta aaggcaagaa taaataatat ccaggacaat     1680

ttattagttt tctcagtatt ttcccaaata ttagaatatt tacttcatta ttggttggct     1740

gccaatgacc ccatatgttc tgtgagaata gtagctttat ctttgatata atacatagtc     1800

tccaaatagg taatacttcg caattgatta gattttcaga gtagatttag agttatctgt     1860

ttttctggtg agggtcaaat atttttgtta attaagctca caaatttgat aaattaagaa     1920

ttatctgcat ttgtctcgta acataataat gtgtaataaa gtctatagaa aattaaaaaa     1980

aaaaaaaaaa                                                            1990


<210>  72
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  72

Met His Leu Leu Ser Ser Ala Cys Val Lys Ala Gly Glu Ser Val Leu 
1               5                   10                  15      


Val His Gly Ala Ser Gly Gly Val Gly Leu Ala Ala Cys Gln Ile Ala 
            20                  25                  30          


Arg Ala Tyr Gly Leu Lys Ile Leu Gly Thr Ala Gly Thr Glu Glu Gly 
        35                  40                  45              


Gln Lys Ile Val Leu Gln Asn Gly Ala His Glu Val Phe Asn His Arg 
    50                  55                  60                  


Glu Val Asn Tyr Ile Asp Lys Ile Lys Lys Tyr Val Gly Glu Lys Gly 
65                  70                  75                  80  


Ile Asp Ile Ile Ile Glu Met Leu Ala Asn Val Asn Leu Ser Lys Asp 
                85                  90                  95      


Leu Ser Leu Leu Ser His Gly Gly Arg Val Ile Val Val Gly Ser Arg 
            100                 105                 110         


Gly Thr Ile Glu Ile Asn Pro Arg Asp Thr Met Ala Lys Glu Ser Ser 
        115                 120                 125             


Ile Ile Gly Val Thr Leu Phe Ser Ser Thr Lys Glu Glu Phe Gln Gln 
    130                 135                 140                 


Tyr Ala Ala Ala Leu Gln Ala Gly Met Glu Ile Gly Trp Leu Lys Pro 
145                 150                 155                 160 


Val Ile Gly Ser Gln Tyr Pro Leu Glu Lys Val Ala Glu Ala His Glu 
                165                 170                 175     


Asn Ile Ile His Gly Ser Gly Ala Thr Gly Lys Met Ile Leu Leu Leu 
            180                 185                 190         


<210>  73
<211>  2278
<212>  DNA
<213>  Homo sapiens

<400>  73
agtaggatgc ggccagcgca ggagctggtg gtgaaaaact gatctcgcat gttcagaaac       60

tgcacaagct ctaccacatc ctcgtcaaca ctgcccttcc ggctgaggtc cgctttgctc      120

aaacattgcg ccttccattt cctgaactcc gcgctgcgat ccatgggtga cggactcagg      180

gtctgcgctc ggctccttca tggtagcctc gtctctccct gggggcagcc atattgaagc      240

gagcggtggc cgaaaaggtc caaacttcct cttcgttctt aatttgggaa attctagtgc      300

cttcgcctag gggtggagag aggcgcacat cctgggtgga gcgaggcgca catcctgggt      360

ggagcctgca aaagttggag aaggtgtggc agtcctcatt tctgtggaat ctgaagaagc      420

ccacgcagat tttaattccc actctagatt ctgtatctag atcaccatgg cgactggaca      480

gaagttgatg agagctgtta gagtttttga atttggtggg ccagaagtcc tgaaattgcg      540

atcagatatt gcagtaccga ttccaaaaga ccatcaggtt ctaatcaagg tccatgcatg      600

tggtgtcaac cccgtggaga catacattcg ctctggtact tatagtagaa aaccactctt      660

accctatact cctggctcag atgtggctgg ggtgatagaa gctgttggag ataatgcatc      720

tgctttcaag aaaggtgaca gagttttcac tagcagcacg atctctgggg gttatgcaga      780

gtatgctctt gcagcagacc acactgttta caaactacct gaaaaactgg actttaaaca      840

aggagctgcc atcggcattc catattttac tgcttatcga gctctgatcc acagtgcctg      900

tgtgaaagct ggagagagtg ttctggttca tggggcaagt ggaggagttg gattagcagc      960

atgccaaatt gctagagctt atggcttaaa gattttgggc actgctggta ctgaggaagg     1020

acaaaagatt gttttgcaaa atggagccca tgaagtgttc aatcacagag aagtgaatta     1080

cattgataaa attaagaagt atgttggtga gaaaggaatt gatataatta ttgaaatgtt     1140

agctaatgta aatcttagta aagacttgag tcttctgtca catggaggac gagtgatagt     1200

tgttggcagc agaggtacta ttgaaataaa cccacgagac accatggcaa aggagtcgag     1260

tataattgga gttactctct tttcctcaac caaggaggaa tttcagcaat atgcagcagc     1320

ccttcaagct ggaatggaaa ttggctggtt gaaacctgtg ataggttctc aatatccatt     1380

ggagaaggtg gccgaggctc atgaaaatat cattcatggt agtggggcta ctggaaaaat     1440

gattcttctc ttatgatgat taattctttc atggatttcc tatgtaatta gaggtactgt     1500

ctttccccca gttgtactta ccctatcttt tctttaatta acattcgatt ccatgagctt     1560

cttatgtgaa aaaataagat ttttctttag agagcagaag cagaagagta aaatttattg     1620

tatagctagc aatatttttt tatgccatct gtctcaaatc aaagagtcat catagtagga     1680

aataacatgt tagttgtcat ttggcatgag tgtgcattcc agtaattctt aattgatatt     1740

tgattaattc catacctttg attaaaacat gctagttcaa aataagactg ctcagtttcc     1800

aagggttttc aagcctactt acctttataa aggttctcta gtctctgatt agccatgact     1860

gtattggact ttgaacattt tctgaactaa aaacctctat tctaaactaa tctcatttgg     1920

atgtgtaagt cttttgtaaa ggcaagaata aataatatcc aggacaattt attagttttc     1980

tcagtatttt cccaaatatt agaatattta cttcattatt ggttggctgc caatgacccc     2040

atatgttctg tgagaatagt agctttatct ttgatataat acatagtctc caaataggta     2100

atacttcgca attgattaga ttttcagagt agatttagag ttatctgttt ttctggtgag     2160

ggtcaaatat ttttgttaat taagctcaca aatttgataa attaagaatt atctgcattt     2220

gtctcgtaac ataataatgt gtaataaagt ctatagaaaa ttaaaaaaaa aaaaaaaa       2278


<210>  74
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Thr Gly Gln Lys Leu Met Arg Ala Val Arg Val Phe Glu Phe 
1               5                   10                  15      


Gly Gly Pro Glu Val Leu Lys Leu Arg Ser Asp Ile Ala Val Pro Ile 
            20                  25                  30          


Pro Lys Asp His Gln Val Leu Ile Lys Val His Ala Cys Gly Val Asn 
        35                  40                  45              


Pro Val Glu Thr Tyr Ile Arg Ser Gly Thr Tyr Ser Arg Lys Pro Leu 
    50                  55                  60                  


Leu Pro Tyr Thr Pro Gly Ser Asp Val Ala Gly Val Ile Glu Ala Val 
65                  70                  75                  80  


Gly Asp Asn Ala Ser Ala Phe Lys Lys Gly Asp Arg Val Phe Thr Ser 
                85                  90                  95      


Ser Thr Ile Ser Gly Gly Tyr Ala Glu Tyr Ala Leu Ala Ala Asp His 
            100                 105                 110         


Thr Val Tyr Lys Leu Pro Glu Lys Leu Asp Phe Lys Gln Gly Ala Ala 
        115                 120                 125             


Ile Gly Ile Pro Tyr Phe Thr Ala Tyr Arg Ala Leu Ile His Ser Ala 
    130                 135                 140                 


Cys Val Lys Ala Gly Glu Ser Val Leu Val His Gly Ala Ser Gly Gly 
145                 150                 155                 160 


Val Gly Leu Ala Ala Cys Gln Ile Ala Arg Ala Tyr Gly Leu Lys Ile 
                165                 170                 175     


Leu Gly Thr Ala Gly Thr Glu Glu Gly Gln Lys Ile Val Leu Gln Asn 
            180                 185                 190         


Gly Ala His Glu Val Phe Asn His Arg Glu Val Asn Tyr Ile Asp Lys 
        195                 200                 205             


Ile Lys Lys Tyr Val Gly Glu Lys Gly Ile Asp Ile Ile Ile Glu Met 
    210                 215                 220                 


Leu Ala Asn Val Asn Leu Ser Lys Asp Leu Ser Leu Leu Ser His Gly 
225                 230                 235                 240 


Gly Arg Val Ile Val Val Gly Ser Arg Gly Thr Ile Glu Ile Asn Pro 
                245                 250                 255     


Arg Asp Thr Met Ala Lys Glu Ser Ser Ile Ile Gly Val Thr Leu Phe 
            260                 265                 270         


Ser Ser Thr Lys Glu Glu Phe Gln Gln Tyr Ala Ala Ala Leu Gln Ala 
        275                 280                 285             


Gly Met Glu Ile Gly Trp Leu Lys Pro Val Ile Gly Ser Gln Tyr Pro 
    290                 295                 300                 


Leu Glu Lys Val Ala Glu Ala His Glu Asn Ile Ile His Gly Ser Gly 
305                 310                 315                 320 


Ala Thr Gly Lys Met Ile Leu Leu Leu 
                325                 


<210>  75
<211>  4597
<212>  DNA
<213>  Homo sapiens

<400>  75
gtccttattt gcacccgccc cccgcccgcg tcggtctggg gcttttgact tctccccgaa       60

cacatttccc ctcccgtcgc tgggtccctg cgatcgcccc cagctggtgg ggctcgcgga      120

gctcagggga gcggggtcct ctgcgccgct gcagcgcgag ttaataaaca gttaagtttg      180

gaagactctg cagacacgtt gagggggagt taccaagccc aggcagcaaa aacatcctgg      240

cacattcctg gggagtcctc agctgccagc atctgattag aaccatatct ctcgccggga      300

gtggccgcgc ggctccgaag ctcccggccg gcggctattt aagcgaggcc cgccgcatcc      360

gctgcgctgt agcctggagg ctccgggcgc ggggaagtca tgctcgcttc acggaggcaa      420

tagctagccg gtgtctgtgg gaggttatgt ttatttgaga cttctccatc gggatcgcct      480

ggtgtcacca agtgtccact ggtactgagg tttgctgcct gccttcttgc catgtctaac      540

gaagtagaaa caagtgcaac caatggtcag cccgaccaac aggccgcacc aaaagcaccc      600

tcaaagaagg aaaaaaagaa aggccctgaa aagacagatg aatatctctt agcaaggttc      660

aaaggcgatg gtgtaaaata taaggccaag ctgattggca ttgatgatgt gccagatgca      720

agaggggata aaatgagcca agactctatg atgaaactaa agggaatggc ggcagctggt      780

cggtctcagg gacaacacaa acaaaggatc tgggtcaaca tttccctttc tgggataaaa      840

ataattgatg agaaaactgg ggtaatagag catgaacatc cagtaaataa gatttctttc      900

attgcccgtg atgtgacaga caaccgggca tttggttacg tgtgtggagg agaaggccag      960

catcagtttt ttgccataaa aaccgggcaa caggctgaac cattagttgt tgatcttaaa     1020

gacctttttc aagttatcta taatgtaaag aaaaaggaag aagaaaagaa aaagatagag     1080

gaagccagca aagcagttga gaatgggagt gaggccctaa tgattctaga tgaccaaact     1140

aacaaactga aatcgggtgt tgaccagatg gatttgtttg gggacatgtc tacacctcct     1200

gacctaaata gtccaacaga aagcaaagat atcctgttag tggatctaaa ctctgaaatc     1260

gacaccaatc agaattcttt aagagaaaat ccattcttaa caaacggcat cacctcctgt     1320

tctcttcctc gaccaacgcc tcaggcatcc ttcttgcctg aaaatgcctt ttctgccaat     1380

ctcaacttct ttcccacccc taatcctgat cctttccgtg acgatccttt cacacagcca     1440

gaccaatcga caccttcttc gtttgattct ctcaaatctc cagatcagaa gaaagagaat     1500

tcgagtagct cgtctactcc gctgagtaat gggcccctga atggtgatgt tgactacttt     1560

ggtcagcaat ttgaccagat ctctaaccgg actggcaaac aggaagctca ggcaggccca     1620

tggccctttt caagttcgca aacccagcca gcagtgagaa ctcaaaatgg ggtatctgaa     1680

agagaacaga acggcttctc tgtcaaatcc tccccgaacc cttttgtggg aagccctccc     1740

aaaggactgt ccatacagaa tggcgtaaag caggacttgg aaagctctgt ccagtcctca     1800

ccacatgact ccatagccat tatcccacct ccacaaagta ccaaaccagg aagaggcaga     1860

aggactgcta agtcttcagc caatgacttg cttgcatcag acatctttgc tcctcccgtc     1920

tcagaacctt caggccaggc gtcacccaca ggacaaccta cagccctgca gcccaaccct     1980

ctggatctct tcaaaacaag tgctcctgcc ccagtggggc ccctggtggg tctaggtggt     2040

gtaactgtca cactccctca ggcaggacca tggaacacag catctttggt cttcaatcag     2100

tccccttcaa tggctccggg agccatgatg ggtggtcaac cttcaggttt tagtcagccc     2160

gtcatttttg gtacaagtcc agctgtttca ggttggaacc agccttcacc ctttgcagcc     2220

tcaactcccc ctccagtgcc tgttgtctgg ggcccttctg catctgtggc acccaatgct     2280

tggtcaacaa caagcccttt ggggaatcct tttcagagca atatttttcc agctcctgct     2340

gtgtccactc agcccccatc catgcactcc tctctcctgg tcactcctcc tcagccacct     2400

cccagagctg gccctcccaa ggacatctcc agtgatgcct tcactgcctt agacccactt     2460

ggggataaag agatcaagga tgtgaaagaa atgtttaagg atttccaact gcggcagcca     2520

cctgctgtgc ccgcgcggaa gggagagcag acttcttctg ggactttgag tgcctttgcc     2580

agttatttca acagcaaggt tggcattcct caggagaatg cagaccatga tgactttgat     2640

gctaatcaac tattgaacaa gatcaatgaa ccaccaaagc cagctcccag acaagtttcc     2700

ctgccagtta ccaaatctac tgacaatgca tttgagaacc ctttctttaa agattctttt     2760

ggttcatcac aagcctctgt ggcttcttct caacctgtat cttctgagat gtatagggat     2820

ccatttggaa atccttttgc ctaaattctg aacttggtct gcagaccatc cagaggaata     2880

aaaaggttgg ccttagtagt caaaaacaaa gctgatagcc agacacgttc tgatttctgc     2940

ccttgttcca gctttgacgt attatctgtt gccttatttc tcattgcctc ttctacttgt     3000

aaaatgcttt tcactttctg tctaggttaa agctaaactg aatctatggc tttaaataaa     3060

ttaagatcct aaactctcta gcttaagtgt aaatgaagta cagtagtttc cctactgaac     3120

cctgcctctt gtgtccctgg aaccttctag aacacctgcc ttctaccctc tggttgggag     3180

atgcagccac cacatccctt catatcatac tgttttgaat aaattttcaa atccttattg     3240

ttcagagttg tttgggggtt ctgtttcaga gcataaaacc taaaggttat agtagaacaa     3300

ggcaccttct taaaagaaat cttgcttcag accatcagtt acagagaatt tctaaagtaa     3360

aattgaagca actacaactt ctccttagac actttggaat ctaaccactt aaggaccttt     3420

ttaaagagat agcttctctt ctttctgaag atcaatttct cccaaggcca agattgtcct     3480

tttctcccat ttcttgctag ctattgcaaa tgagggaaga acattattca tctctcctcc     3540

cctttttttt ctgattcttt tttcagtcag ttttgctcct gggttcaagt agtattacca     3600

ccctttcaca agcaacagac tctcacaggg caaaaaaaaa aaaaaatcta atgattcaca     3660

gacagatctg gagcctctct tcattctcag taattgctag tcccaagaac tagaattgca     3720

aatgggcaca acctatatcc ttcctgtgga agaggaggcc actctcttga gctgaagttc     3780

cagaagagca gttaatgttc aagagaaatt gaactcaact cagcaacaaa ggactctatt     3840

ttgaagagca acatatcaca aagctaaatg tgattgtgcc aaacacatta ggtgcttatt     3900

tggggtcatg ctaggccttt atcaagtaac tggaaaactt ttcttgcagc cacaatctca     3960

atgtcgttag taggaagata agaggggaga aaaagctgta gaacaaatgt ttggggttac     4020

cattgaaaat ctaatgtctg caatattttt ctcctcacaa cttggaaacg ttcccagttc     4080

attttcagtc ctgttgtgag cacagttctg aagggtttat tattgtcaaa ataagttttg     4140

ttttgttttg tttatgttgg gtttttaatg ttgtctcttg acccttaatg ctcaggttct     4200

tgtgggagtt aatcagccac atccaatgtt accttgaggg ggaagaagag ggtgatgctc     4260

agaagctaaa caagacaggg gccacatgac cctctattga ttagccccaa gtagaaagtc     4320

ctgtggtttt atgtttaatg gtaatagttg atcatatatg gcataatttt ctatcagctt     4380

cctactcagt cactataaac acagacttga aatagtactt taaatgtcca aatacctaaa     4440

tgtgctaaac tggaggtaac tatttctagg tagttgaatt tttgaaagtc atgatcagcc     4500

acacaactgt tttgtacata cttattttct catgcacttt tctgtatgca aataaagcta     4560

taaatttact catttcaata aactggagtg gcagaat                              4597


<210>  76
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Thr Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn 
225                 230                 235                 240 


Ser Glu Ile Asp Thr Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                245                 250                 255     


Thr Asn Gly Ile Thr Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala 
            260                 265                 270         


Ser Phe Leu Pro Glu Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
        275                 280                 285             


Thr Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp 
    290                 295                 300                 


Gln Ser Thr Pro Ser Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys 
305                 310                 315                 320 


Lys Glu Asn Ser Ser Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu 
                325                 330                 335     


Asn Gly Asp Val Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
            340                 345                 350         


Arg Thr Gly Lys Gln Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser 
        355                 360                 365             


Ser Gln Thr Gln Pro Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg 
    370                 375                 380                 


Glu Gln Asn Gly Phe Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly 
385                 390                 395                 400 


Ser Pro Pro Lys Gly Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu 
                405                 410                 415     


Glu Ser Ser Val Gln Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro 
            420                 425                 430         


Pro Pro Gln Ser Thr Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser 
        435                 440                 445             


Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser 
    450                 455                 460                 


Glu Pro Ser Gly Gln Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln 
465                 470                 475                 480 


Pro Asn Pro Leu Asp Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly 
                485                 490                 495     


Pro Leu Val Gly Leu Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly 
            500                 505                 510         


Pro Trp Asn Thr Ala Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala 
        515                 520                 525             


Pro Gly Ala Met Met Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val 
    530                 535                 540                 


Ile Phe Gly Thr Ser Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro 
545                 550                 555                 560 


Phe Ala Ala Ser Thr Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser 
                565                 570                 575     


Ala Ser Val Ala Pro Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn 
            580                 585                 590         


Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro 
        595                 600                 605             


Pro Ser Met His Ser Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro 
    610                 615                 620                 


Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu 
625                 630                 635                 640 


Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys 
                645                 650                 655     


Asp Phe Gln Leu Arg Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu 
            660                 665                 670         


Gln Thr Ser Ser Gly Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser 
        675                 680                 685             


Lys Val Gly Ile Pro Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala 
    690                 695                 700                 


Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
705                 710                 715                 720 


Gln Val Ser Leu Pro Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn 
                725                 730                 735     


Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser 
            740                 745                 750         


Ser Gln Pro Val Ser Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro 
        755                 760                 765             


Phe Ala 
    770 


<210>  77
<211>  3348
<212>  DNA
<213>  Homo sapiens

<400>  77
tagcgggcgg agttgaaggg cgcttggacc ccagcggcga tctgtgtttg ggttcgcgct       60

ctgggagaat tttggctttg ctcgccttcc tctttcagaa gactcgaaat cggccagcag      120

gtctgcgaga tttgaaacgc gactgttact ccttgttttc cggttctggc cgcgggagcc      180

tctcgagaag cgtggaaaga ggagaagggc gtataccttg tgaccgcctc tggttgtctt      240

gggctcgcgc ctggcgccgc tacgtggagt cgctctctcg tcgtcacttt tggctgccga      300

cttgttgagt agaagtgcag actgatgctt taagactcag ggagaggtct ttcccttatc      360

tccaccccag caagcacccc agagaccttg gagatttgtc ttgtttctag acacgtgtac      420

tccaatgttg tgcggaggag gccttaaata ttcgagaaga gagtgggaac tcctggaatt      480

ttaagggatt tctgtgtatt tccaaaactg acttttaact accggcagcg tgggatttcg      540

tgattgtttt tcgccatcgt gtggctccaa catgtacttc ccttcttggt taagtcagct      600

gtacaggggt ttatccagac ccatcagaag gaccacccaa ccgatctggg gttctctcta      660

cagaagtctg ttgcagagtt cacagaggag aattccagaa ttcagtagct ttgttgtccg      720

gaccaacaca tgtggagagt tgcgttcgtc tcacttaggc caagaagtca ccttgtgtgg      780

atggattcag taccgaaggc aaaacacatt cttggtccta agagatttcg atgggcttgt      840

tcaagttatc attccccagg atgagtcggc agcctctgtg aagaagattt tatgtgaagc      900

ccctgtggaa tctgtggtgc aagtgtctgg tacagtcatt tcccgtcctg caggacaaga      960

gaatccaaaa atgccaacag gtgagattga aatcaaagtt aaaacagctg agcttctgaa     1020

tgcctgcaag aagctgccct ttgaaattaa gaacttcgtg aagaaaacag aggctcttcg     1080

gttgcagtat cgctacttag acttgcgtag tttccaaatg cagtataacc tgcgactgag     1140

gtcccagatg gtcatgaaaa tgcgggaata tctctgtaat ctgcatgggt ttgtggatat     1200

agaaaccccc acattgttta agaggacccc agggggtgcc aaagagtttt tagtaccatc     1260

cagggaacct ggaaagtttt attctctccc tcagagtcct caacagttta agcaacttct     1320

gatggttggc ggtttagaca gatattttca ggttgcccga tgttatcgag atgaaggttc     1380

aagaccagac agacagcctg agtttactca gattgacata gagatgtcat ttgtagacca     1440

gactgggatc cagagtttaa ttgagggttt gctccagtat tcctggccca atgacaaaga     1500

tcctgtggtt gttccttttc ctactatgac ttttgctgag gtgctggcca cctatggaac     1560

tgataaacct gacactcgct ttggaatgaa gattatagat atcagtgatg tgtttagaaa     1620

cacagagatt ggatttcttc aagatgcact tagtaagccc catggaactg tgaaagccat     1680

atgtatccct gaaggagcaa aatacttaaa aaggaaagac attgaatcca ttagaaactt     1740

tgcagctgac cattttaatc aggaaatctt acctgtattc cttaacgcca atagaaactg     1800

gaattctcca gttgctaatt tcataatgga gtcacaaaga ctggaattaa tcagactaat     1860

ggagacccaa gaggaagatg tggtcctact aactgctgga gagcacaata aagcatgctc     1920

tttgttagga aaattacgac tggaatgtgc tgaccttcta gaaacaagag gagtggtgct     1980

ccgtgacccc actctgttct ctttcctttg ggtggtagat ttcccactct tcctgcccaa     2040

ggaggaaaat cccagagagc tggaatcggc ccaccaccca tttactgctc cccaccccag     2100

tgacatacat ctcctgtaca ctgagcccaa aaaggcccgt agccaacact atgacttggt     2160

tttaaatggc aatgaaatag gaggtggttc aattcgaatt cacaatgcag agctgcagcg     2220

ttatatcctg gcaaccttac taaaggagga tgtgaaaatg ctctcccatc tgctccaggc     2280

tttagattat ggggcacccc ctcatggagg aattgcctta gggttagaca gactgatatg     2340

ccttgtcact ggatctccaa gcatcagaga tgtcatagcc ttcccaaagt ccttccgggg     2400

acatgacctc atgagcaata ccccagattc tgtccctcct gaggaactga agccctatca     2460

tatccgagtc tccaagccaa cagactccaa agcagaaaga gctcattgaa tcatgcatac     2520

catgcagaaa gttgagcttt taggttttgt cctctttgct tccccaaggc taaagtcaga     2580

tctagagttc tgccacaggt ctaacaatca agtctttaga tggaaggaat ccaggcaaca     2640

ttcttcacca caacgaagaa acagataaaa gatacccaat tttgacttga tttcatgcat     2700

catttggatt ttttttggtt aggacttttt ttgaagttcc tttttactta ggtgtgaaag     2760

atggttcttt gttgaaataa tatagtggtt tagtgttttc aaatcatgtt tctcataccc     2820

agatagtaga ttattcactt aggacagagg taatcaaatt atgtgtgaaa tgtaggaaaa     2880

tgcttgcccc tgtaaactag tgagttgatg gagcatttgc ttcatcatcc tcatcaagag     2940

aatcatataa attaagcttt ataatgacat ttcaaccatc aacataatat agtgaggagt     3000

agcataatat tttttaataa tgcagaaaac atcactgaaa tgagagtcac aaatttttct     3060

tcagtgtttc agcctgagta agttacataa acctcgctta gcctcccttc ctgctaatgt     3120

gtaaaataca tacttgccct ggctacctca ccgggctgtt attgctggaa tcagaggaga     3180

taacatatat ggaagataaa gtgaataaaa gtactttgaa aaactataaa gcattccaca     3240

aatatgagat gatggtatta tccatccata aataggtaga tatatctcta ttttatagtt     3300

tcagattaaa caaaactgat atcaatagta aaagtcattt tacttatc                  3348


<210>  78
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg 
1               5                   10                  15      


Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser 
            20                  25                  30          


Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe Val 
        35                  40                  45              


Val Arg Thr Asn Thr Cys Gly Glu Leu Arg Ser Ser His Leu Gly Gln 
    50                  55                  60                  


Glu Val Thr Leu Cys Gly Trp Ile Gln Tyr Arg Arg Gln Asn Thr Phe 
65                  70                  75                  80  


Leu Val Leu Arg Asp Phe Asp Gly Leu Val Gln Val Ile Ile Pro Gln 
                85                  90                  95      


Asp Glu Ser Ala Ala Ser Val Lys Lys Ile Leu Cys Glu Ala Pro Val 
            100                 105                 110         


Glu Ser Val Val Gln Val Ser Gly Thr Val Ile Ser Arg Pro Ala Gly 
        115                 120                 125             


Gln Glu Asn Pro Lys Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys 
    130                 135                 140                 


Thr Ala Glu Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys 
145                 150                 155                 160 


Asn Phe Val Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu 
                165                 170                 175     


Asp Leu Arg Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln 
            180                 185                 190         


Met Val Met Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val 
        195                 200                 205             


Asp Ile Glu Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys 
    210                 215                 220                 


Glu Phe Leu Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro 
225                 230                 235                 240 


Gln Ser Pro Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp 
                245                 250                 255     


Arg Tyr Phe Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro 
            260                 265                 270         


Asp Arg Gln Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val 
        275                 280                 285             


Asp Gln Thr Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser 
    290                 295                 300                 


Trp Pro Asn Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr 
305                 310                 315                 320 


Phe Ala Glu Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg 
                325                 330                 335     


Phe Gly Met Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu 
            340                 345                 350         


Ile Gly Phe Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys 
        355                 360                 365             


Ala Ile Cys Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile 
    370                 375                 380                 


Glu Ser Ile Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu 
385                 390                 395                 400 


Pro Val Phe Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn 
                405                 410                 415     


Phe Ile Met Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr 
            420                 425                 430         


Gln Glu Glu Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala 
        435                 440                 445             


Cys Ser Leu Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Glu 
    450                 455                 460                 


Thr Arg Gly Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp 
465                 470                 475                 480 


Val Val Asp Phe Pro Leu Phe Leu Pro Lys Glu Glu Asn Pro Arg Glu 
                485                 490                 495     


Leu Glu Ser Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile 
            500                 505                 510         


His Leu Leu Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp 
        515                 520                 525             


Leu Val Leu Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His 
    530                 535                 540                 


Asn Ala Glu Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp 
545                 550                 555                 560 


Val Lys Met Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro 
                565                 570                 575     


Pro His Gly Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val 
            580                 585                 590         


Thr Gly Ser Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe 
        595                 600                 605             


Arg Gly His Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu 
    610                 615                 620                 


Glu Leu Lys Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys 
625                 630                 635                 640 


Ala Glu Arg Ala His 
                645 


<210>  79
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  79
agggcgcagc aggccaaggg ggaggtgcga gcgtggacct gggacgggtc tgggcggctc       60

tcggtggttg gcacgggttc gcacacccat tcaagcggca ggacgcactt gtcttagcag      120

ttctcgctga ccgcgctagc tgcggcttct acgctccggc actctgagtt catcagcaaa      180

cgccctggcg tctgtcctca ccatgcctag cctttgggac cgcttctcgt cgtcgtccac      240

ctcctcttcg ccctcgtcct tgccccgaac tcccacccca gatcggccgc cgcgctcagc      300

ctgggggtcg gcgacccggg aggaggggtt tgaccgctcc acgagcctgg agagctcgga      360

ctgcgagtcc ctggacagca gcaacagtgg cttcgggccg gaggaagaca cggcttacct      420

ggatggggtg tcgttgcccg acttcgagct gctcagtgac cctgaggatg aacacttgtg      480

tgccaacctg atgcagctgc tgcaggagag cctggcccag gcgcggctgg gctctcgacg      540

ccctgcgcgc ctgctgatgc ctagccagtt ggtaagccag gtgggcaaag aactactgcg      600

cctggcctac agcgagccgt gcggcctgcg gggggcgctg ctggacgtct gcgtggagca      660

gggcaagagc tgccacagcg tgggccagct ggcactcgac cccagcctgg tgcccacctt      720

ccagctgacc ctcgtgctgc gcctggactc acgactctgg cccaagatcc aggggctgtt      780

tagctccgcc aactctccct tcctccctgg cttcagccag tccctgacgc tgagcactgg      840

cttccgagtc atcaagaaga agctgtacag ctcggaacag ctgctcattg aggagtgttg      900

aacttcaacc tgagggggcc gacagtgccc tccaagacag agacgactga acttttgggg      960

tggagactag aggcaggagc tgagggactg attcctgtgg ttggaaaact gaggcagcca     1020

cctaaggtgg aggtggggga atagtgtttc ccaggaagct cattgagttg tgtgcgggtg     1080

gctgtgcatt ggggacacat acccctcagt actgtagcat gaaacaaagg cttaggggcc     1140

aacaaggctt ccagctggat gtgtgtgtag catgtacctt attatttttg ttactgacag     1200

ttaacagtgg tgtgacatcc agagagcagc tgggctgctc ccgccccagc ccggcccagg     1260

gtgaaggaag aggcacgtgc tcctcagagc agccggaggg aggggggagg tcggaggtcg     1320

tggaggtggt ttgtgtatct tactggtctg aagggaccaa gtgtgtttgt tgtttgtttt     1380

gtatcttgtt tttctgatcg gagcatcact actgacctgt tgtaggcagc tatcttacag     1440

acgcatgaat gtaagagtag gaaggggtgg gtgtcaggga tcacttggga tctttgacac     1500

ttgaaaaatt acacctggca gctgcgttta agccttcccc catcgtgtac tgcagagttg     1560

agctggcagg ggaggggctg agagggtggg ggctggaacc cctccccggg aggagtgcca     1620

tctgggtctt ccatctagaa ctgtttacat gaagataaga tactcactgt tcatgaatac     1680

acttgatgtt caagtattaa gacctatgca atatttttta cttttctaat aaacatgttt     1740

gttaaaacag tt                                                         1752


<210>  80
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  81
<211>  4014
<212>  DNA
<213>  Homo sapiens

<400>  81
tggcggtggt ggcggtggcg gcggcggtgg tggtggtggc ggcggcggcg gcgaaggggg       60

cggagaggaa ggagcgcggc gggaccgggc cgggacagcg cgtactttgg gctccgggat      120

tcgctccgcg cccgcggttg tagcagctgc cgctgcagcc atagcagcag gacttcctca      180

agcgcaggga ctatgtctta aggcgctttg cagagccaag ctcatttctg gcacataaga      240

ggtcagtcat tggcaccatg aactggaata aaggtggtcc tggcactaag cgaggatttg      300

gctttggagg ttttgccatc agtgctggga aaaaggagga acccaaactc ccacagcagt      360

cccacagtgc ctttggggca accagctctt cttctggatt tggaaagtca gctccaccac      420

agcttccttc tttctacaaa attggatcta agcgggccaa ctttgatgaa gaaaatgcct      480

attttgaaga tgaggaagaa gattctagca acgttgattt accttacatt cctgctgaaa      540

actcaccaac tcgccagcaa ttccattcca agccagtaga ttctgacagc gatgatgatc      600

ccttggaggc attcatggct gaagtggagg atcaggcagc tagagacatg aagaggcttg      660

aagaaaagga caaggaaaga aaaaacgtaa agggtattcg agatgacatt gaagaggaag      720

atgaccaaga agcttatttt cgatacatgg cagaaaaccc aactgctggt gtggttcagg      780

aggaagagga agacaatcta gaatatgata gtgacggaaa tccaattgca cctaccaaaa      840

aaatcattga tcctcttccc cccattgatc attcagagat tgactatcca ccatttgaaa      900

aaaactttta caatgagcat gaagagataa ccaacctcac tccacagcag ttaatagatc      960

tccggcataa gctcaatctt cgggtctctg gtgctgcacc tcctagacca ggaagtagct     1020

ttgctcattt tgggtttgac gaacaactta tgcaccagat tcggaaatct gaatacacac     1080

agcccactcc aatacagtgc cagggtgtgc ctgtggcatt aagtggtaga gacatgattg     1140

gtattgccaa aacaggtagt gggaaaactg cagccttcat ttggcccatg ttgattcata     1200

taatggacca gaaggagttg gaaccaggtg atggaccaat tgcagtgatt gtgtgtccta     1260

ccagggagct ttgccagcag atccatgcag aatgtaagcg gtttggaaaa gcatataatc     1320

ttcgatcagt ggccgtatat ggaggaggga gtatgtggga gcaggccaag gcccttcagg     1380

agggggcaga gattgttgtg tgtaccccag gtcgactgat agatcatgtg aaaaagaaag     1440

ctaccaatct tcaaagagtc tcttaccttg tgtttgatga agcagatcga atgtttgaca     1500

tgggatttga gtaccaagtt cgatccatag caagtcatgt tcgtcctgac aggcagactc     1560

tcttatttag tgcaactttt cggaagaaga ttgaaaagtt ggccagagac atcctgatcg     1620

accctattcg agtggtgcag ggagatattg gagaggcaaa tgaagatgtg acacagattg     1680

tggagattct ccattctgga cctagtaaat ggaactggct tacccggcgt ctggtagaat     1740

ttacctcttc agggagtgtc ctcctctttg ttactaaaaa agccaatgct gaagagctag     1800

cgaataacct taaacaggag ggtcataatc ttgggctgct ccatggggat atggatcaga     1860

gtgagagaaa caaggtcatt tcagacttta agaaaaagga catcccagtc ctggtggcca     1920

cagatgttgc agcccgtggt ctggacattc cttcaattaa gactgtcatt aactatgatg     1980

tggcacgaga cattgatacc cacacgcata ggattggccg cacaggaaga gcgggtgaga     2040

aaggtgtggc ctatacccta ctcactccca aggacagcaa ttttgctggt gacctggtcc     2100

ggaacttgga aggagccaat caacacgttt ctaaggaact cctagatctg gcaatgcaga     2160

atgcctggtt tcggaaatct cgattcaaag gagggaaagg aaaaaagctg aacattggtg     2220

gaggaggcct aggctacagg gagcggcctg gcctgggctc tgagaacatg gatcgaggaa     2280

ataacaatgt aatgagcaat tatgaggcct acaagccttc cacaggagct atgggagatc     2340

gactaacggc aatgaaagca gctttccagt cacagtacaa gagtcacttt gttgcagcca     2400

gtttaagtaa tcagaaggct ggaagttctg ctgctggggc aagtgggtgg actagtgcag     2460

ggagcttgaa ttctgttcca actaactcag cacaacaggg ccataacagt cctgacagcc     2520

ccgtcaccag tgccgccaag ggcatcccag gctttggcaa tactggcaac atcagtggtg     2580

cccctgtgac ctacccgtct gccggagccc aaggagtcaa caacacagct tcagggaata     2640

acagccgaga agggactggg ggcagcaacg ggaaaagaga gagatatact gagaaccggg     2700

gcagcagccg tcacagtcac ggagagactg gcaatcggca tagcgatagt ccacgtcacg     2760

gagatggtgg tcgccatgga gatggatacc gccatccaga aagcagcagc cgtcatactg     2820

atggccatcg gcacggggag aacagacatg gaggaagcgc aggccggcat ggggagaacc     2880

ggggtgcaaa tgatggtcgg aatggggaaa gcaggaaaga agcttttaat cgtgagagca     2940

agatggagcc caagatggaa cccaaagtgg acagcagcaa gatggacaag gtggacagca     3000

agacagataa gacagctgac ggctttgctg tcccagagcc gcctaaacgc aagaaaagtc     3060

gatgggacag ttagagggga tgtgctaaag cgtgaaatca gttgtcctta atttttagaa     3120

agattttggt aactaggtgt ctcagggctg ggttggggtc caaagtgtaa ggaccccctg     3180

cccttagtgg agagctggag cttggagaca ttaccccttc atcagaagga attttcggat     3240

gttttcttgg gaagctgttt tggtccttgg aagcagtgag agctgggaag cttcttttgg     3300

ctctaggtga gttgtcatgt gggtaagttg aggttatctt gggataaagg gtcttctagg     3360

gcacaaaact cactctaggt ttatattgta tgtagcttat attttttact aaggtgtcac     3420

cttataagca tctataaatt gacttctttt tcttagttgt atggccaggc agtccccatt     3480

ttaggagttg gcttctgcaa attcaatcca ttgagctaac tgttggggag caatttggta     3540

gttgtagaca tttgcaggga agggagatgt ctgattctaa atgggagttg atgctcaggt     3600

ccccagccag gtttgcatcc agccctgaga catgtaggaa acacctttca gacccaggct     3660

ctgaagattc ccagaagcca caaggattga agggaaaagg tgatcctggt aactgttcca     3720

ggattgctcc aggtttgaga tggtattgct aaatttaaaa ttaaacaaga aacccaacaa     3780

cagcttttaa agtgtcttct atctcattgt atttttttta acttgcccca atgatagaaa     3840

agtcttttgc tgaaatgatt ttgatgattt ttgtttatcg tttataaaaa ggaaaagaaa     3900

tatacaaact ttgacttttg tgactttgtg aaggtttctt taagatgtgc attcctttct     3960

gcttgctctc tagtaaatgt tttactaccg ggaaaaaaaa aaaaaaaaaa aaaa           4014


<210>  82
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Asn Trp Asn Lys Gly Gly Pro Gly Thr Lys Arg Gly Phe Gly Phe 
1               5                   10                  15      


Gly Gly Phe Ala Ile Ser Ala Gly Lys Lys Glu Glu Pro Lys Leu Pro 
            20                  25                  30          


Gln Gln Ser His Ser Ala Phe Gly Ala Thr Ser Ser Ser Ser Gly Phe 
        35                  40                  45              


Gly Lys Ser Ala Pro Pro Gln Leu Pro Ser Phe Tyr Lys Ile Gly Ser 
    50                  55                  60                  


Lys Arg Ala Asn Phe Asp Glu Glu Asn Ala Tyr Phe Glu Asp Glu Glu 
65                  70                  75                  80  


Glu Asp Ser Ser Asn Val Asp Leu Pro Tyr Ile Pro Ala Glu Asn Ser 
                85                  90                  95      


Pro Thr Arg Gln Gln Phe His Ser Lys Pro Val Asp Ser Asp Ser Asp 
            100                 105                 110         


Asp Asp Pro Leu Glu Ala Phe Met Ala Glu Val Glu Asp Gln Ala Ala 
        115                 120                 125             


Arg Asp Met Lys Arg Leu Glu Glu Lys Asp Lys Glu Arg Lys Asn Val 
    130                 135                 140                 


Lys Gly Ile Arg Asp Asp Ile Glu Glu Glu Asp Asp Gln Glu Ala Tyr 
145                 150                 155                 160 


Phe Arg Tyr Met Ala Glu Asn Pro Thr Ala Gly Val Val Gln Glu Glu 
                165                 170                 175     


Glu Glu Asp Asn Leu Glu Tyr Asp Ser Asp Gly Asn Pro Ile Ala Pro 
            180                 185                 190         


Thr Lys Lys Ile Ile Asp Pro Leu Pro Pro Ile Asp His Ser Glu Ile 
        195                 200                 205             


Asp Tyr Pro Pro Phe Glu Lys Asn Phe Tyr Asn Glu His Glu Glu Ile 
    210                 215                 220                 


Thr Asn Leu Thr Pro Gln Gln Leu Ile Asp Leu Arg His Lys Leu Asn 
225                 230                 235                 240 


Leu Arg Val Ser Gly Ala Ala Pro Pro Arg Pro Gly Ser Ser Phe Ala 
                245                 250                 255     


His Phe Gly Phe Asp Glu Gln Leu Met His Gln Ile Arg Lys Ser Glu 
            260                 265                 270         


Tyr Thr Gln Pro Thr Pro Ile Gln Cys Gln Gly Val Pro Val Ala Leu 
        275                 280                 285             


Ser Gly Arg Asp Met Ile Gly Ile Ala Lys Thr Gly Ser Gly Lys Thr 
    290                 295                 300                 


Ala Ala Phe Ile Trp Pro Met Leu Ile His Ile Met Asp Gln Lys Glu 
305                 310                 315                 320 


Leu Glu Pro Gly Asp Gly Pro Ile Ala Val Ile Val Cys Pro Thr Arg 
                325                 330                 335     


Glu Leu Cys Gln Gln Ile His Ala Glu Cys Lys Arg Phe Gly Lys Ala 
            340                 345                 350         


Tyr Asn Leu Arg Ser Val Ala Val Tyr Gly Gly Gly Ser Met Trp Glu 
        355                 360                 365             


Gln Ala Lys Ala Leu Gln Glu Gly Ala Glu Ile Val Val Cys Thr Pro 
    370                 375                 380                 


Gly Arg Leu Ile Asp His Val Lys Lys Lys Ala Thr Asn Leu Gln Arg 
385                 390                 395                 400 


Val Ser Tyr Leu Val Phe Asp Glu Ala Asp Arg Met Phe Asp Met Gly 
                405                 410                 415     


Phe Glu Tyr Gln Val Arg Ser Ile Ala Ser His Val Arg Pro Asp Arg 
            420                 425                 430         


Gln Thr Leu Leu Phe Ser Ala Thr Phe Arg Lys Lys Ile Glu Lys Leu 
        435                 440                 445             


Ala Arg Asp Ile Leu Ile Asp Pro Ile Arg Val Val Gln Gly Asp Ile 
    450                 455                 460                 


Gly Glu Ala Asn Glu Asp Val Thr Gln Ile Val Glu Ile Leu His Ser 
465                 470                 475                 480 


Gly Pro Ser Lys Trp Asn Trp Leu Thr Arg Arg Leu Val Glu Phe Thr 
                485                 490                 495     


Ser Ser Gly Ser Val Leu Leu Phe Val Thr Lys Lys Ala Asn Ala Glu 
            500                 505                 510         


Glu Leu Ala Asn Asn Leu Lys Gln Glu Gly His Asn Leu Gly Leu Leu 
        515                 520                 525             


His Gly Asp Met Asp Gln Ser Glu Arg Asn Lys Val Ile Ser Asp Phe 
    530                 535                 540                 


Lys Lys Lys Asp Ile Pro Val Leu Val Ala Thr Asp Val Ala Ala Arg 
545                 550                 555                 560 


Gly Leu Asp Ile Pro Ser Ile Lys Thr Val Ile Asn Tyr Asp Val Ala 
                565                 570                 575     


Arg Asp Ile Asp Thr His Thr His Arg Ile Gly Arg Thr Gly Arg Ala 
            580                 585                 590         


Gly Glu Lys Gly Val Ala Tyr Thr Leu Leu Thr Pro Lys Asp Ser Asn 
        595                 600                 605             


Phe Ala Gly Asp Leu Val Arg Asn Leu Glu Gly Ala Asn Gln His Val 
    610                 615                 620                 


Ser Lys Glu Leu Leu Asp Leu Ala Met Gln Asn Ala Trp Phe Arg Lys 
625                 630                 635                 640 


Ser Arg Phe Lys Gly Gly Lys Gly Lys Lys Leu Asn Ile Gly Gly Gly 
                645                 650                 655     


Gly Leu Gly Tyr Arg Glu Arg Pro Gly Leu Gly Ser Glu Asn Met Asp 
            660                 665                 670         


Arg Gly Asn Asn Asn Val Met Ser Asn Tyr Glu Ala Tyr Lys Pro Ser 
        675                 680                 685             


Thr Gly Ala Met Gly Asp Arg Leu Thr Ala Met Lys Ala Ala Phe Gln 
    690                 695                 700                 


Ser Gln Tyr Lys Ser His Phe Val Ala Ala Ser Leu Ser Asn Gln Lys 
705                 710                 715                 720 


Ala Gly Ser Ser Ala Ala Gly Ala Ser Gly Trp Thr Ser Ala Gly Ser 
                725                 730                 735     


Leu Asn Ser Val Pro Thr Asn Ser Ala Gln Gln Gly His Asn Ser Pro 
            740                 745                 750         


Asp Ser Pro Val Thr Ser Ala Ala Lys Gly Ile Pro Gly Phe Gly Asn 
        755                 760                 765             


Thr Gly Asn Ile Ser Gly Ala Pro Val Thr Tyr Pro Ser Ala Gly Ala 
    770                 775                 780                 


Gln Gly Val Asn Asn Thr Ala Ser Gly Asn Asn Ser Arg Glu Gly Thr 
785                 790                 795                 800 


Gly Gly Ser Asn Gly Lys Arg Glu Arg Tyr Thr Glu Asn Arg Gly Ser 
                805                 810                 815     


Ser Arg His Ser His Gly Glu Thr Gly Asn Arg His Ser Asp Ser Pro 
            820                 825                 830         


Arg His Gly Asp Gly Gly Arg His Gly Asp Gly Tyr Arg His Pro Glu 
        835                 840                 845             


Ser Ser Ser Arg His Thr Asp Gly His Arg His Gly Glu Asn Arg His 
    850                 855                 860                 


Gly Gly Ser Ala Gly Arg His Gly Glu Asn Arg Gly Ala Asn Asp Gly 
865                 870                 875                 880 


Arg Asn Gly Glu Ser Arg Lys Glu Ala Phe Asn Arg Glu Ser Lys Met 
                885                 890                 895     


Glu Pro Lys Met Glu Pro Lys Val Asp Ser Ser Lys Met Asp Lys Val 
            900                 905                 910         


Asp Ser Lys Thr Asp Lys Thr Ala Asp Gly Phe Ala Val Pro Glu Pro 
        915                 920                 925             


Pro Lys Arg Lys Lys Ser Arg Trp Asp Ser 
    930                 935             


<210>  83
<211>  3943
<212>  DNA
<213>  Homo sapiens

<400>  83
tggcggtggt ggcggtggcg gcggcggtgg tggtggtggc ggcggcggcg gcgaaggggg       60

cggagaggaa ggagcgcggc gggaccgggc cgggacagcg cgtactttgg gctccgggat      120

tcgctccgcg cccgcggttg tagcagctgc cgctgcagcc atagcagcag gtcagtcatt      180

ggcaccatga actggaataa aggtggtcct ggcactaagc gaggatttgg ctttggaggt      240

tttgccatca gtgctgggaa aaaggaggaa cccaaactcc cacagcagtc ccacagtgcc      300

tttggggcaa ccagctcttc ttctggattt ggaaagtcag ctccaccaca gcttccttct      360

ttctacaaaa ttggatctaa gcgggccaac tttgatgaag aaaatgccta ttttgaagat      420

gaggaagaag attctagcaa cgttgattta ccttacattc ctgctgaaaa ctcaccaact      480

cgccagcaat tccattccaa gccagtagat tctgacagcg atgatgatcc cttggaggca      540

ttcatggctg aagtggagga tcaggcagct agagacatga agaggcttga agaaaaggac      600

aaggaaagaa aaaacgtaaa gggtattcga gatgacattg aagaggaaga tgaccaagaa      660

gcttattttc gatacatggc agaaaaccca actgctggtg tggttcagga ggaagaggaa      720

gacaatctag aatatgatag tgacggaaat ccaattgcac ctaccaaaaa aatcattgat      780

cctcttcccc ccattgatca ttcagagatt gactatccac catttgaaaa aaacttttac      840

aatgagcatg aagagataac caacctcact ccacagcagt taatagatct ccggcataag      900

ctcaatcttc gggtctctgg tgctgcacct cctagaccag gaagtagctt tgctcatttt      960

gggtttgacg aacaacttat gcaccagatt cggaaatctg aatacacaca gcccactcca     1020

atacagtgcc agggtgtgcc tgtggcatta agtggtagag acatgattgg tattgccaaa     1080

acaggtagtg ggaaaactgc agccttcatt tggcccatgt tgattcatat aatggaccag     1140

aaggagttgg aaccaggtga tggaccaatt gcagtgattg tgtgtcctac cagggagctt     1200

tgccagcaga tccatgcaga atgtaagcgg tttggaaaag catataatct tcgatcagtg     1260

gccgtatatg gaggagggag tatgtgggag caggccaagg cccttcagga gggggcagag     1320

attgttgtgt gtaccccagg tcgactgata gatcatgtga aaaagaaagc taccaatctt     1380

caaagagtct cttaccttgt gtttgatgaa gcagatcgaa tgtttgacat gggatttgag     1440

taccaagttc gatccatagc aagtcatgtt cgtcctgaca ggcagactct cttatttagt     1500

gcaacttttc ggaagaagat tgaaaagttg gccagagaca tcctgatcga ccctattcga     1560

gtggtgcagg gagatattgg agaggcaaat gaagatgtga cacagattgt ggagattctc     1620

cattctggac ctagtaaatg gaactggctt acccggcgtc tggtagaatt tacctcttca     1680

gggagtgtcc tcctctttgt tactaaaaaa gccaatgctg aagagctagc gaataacctt     1740

aaacaggagg gtcataatct tgggctgctc catggggata tggatcagag tgagagaaac     1800

aaggtcattt cagactttaa gaaaaaggac atcccagtcc tggtggccac agatgttgca     1860

gcccgtggtc tggacattcc ttcaattaag actgtcatta actatgatgt ggcacgagac     1920

attgataccc acacgcatag gattggccgc acaggaagag cgggtgagaa aggtgtggcc     1980

tataccctac tcactcccaa ggacagcaat tttgctggtg acctggtccg gaacttggaa     2040

ggagccaatc aacacgtttc taaggaactc ctagatctgg caatgcagaa tgcctggttt     2100

cggaaatctc gattcaaagg agggaaagga aaaaagctga acattggtgg aggaggccta     2160

ggctacaggg agcggcctgg cctgggctct gagaacatgg atcgaggaaa taacaatgta     2220

atgagcaatt atgaggccta caagccttcc acaggagcta tgggagatcg actaacggca     2280

atgaaagcag ctttccagtc acagtacaag agtcactttg ttgcagccag tttaagtaat     2340

cagaaggctg gaagttctgc tgctggggca agtgggtgga ctagtgcagg gagcttgaat     2400

tctgttccaa ctaactcagc acaacagggc cataacagtc ctgacagccc cgtcaccagt     2460

gccgccaagg gcatcccagg ctttggcaat actggcaaca tcagtggtgc ccctgtgacc     2520

tacccgtctg ccggagccca aggagtcaac aacacagctt cagggaataa cagccgagaa     2580

gggactgggg gcagcaacgg gaaaagagag agatatactg agaaccgggg cagcagccgt     2640

cacagtcacg gagagactgg caatcggcat agcgatagtc cacgtcacgg agatggtggt     2700

cgccatggag atggataccg ccatccagaa agcagcagcc gtcatactga tggccatcgg     2760

cacggggaga acagacatgg aggaagcgca ggccggcatg gggagaaccg gggtgcaaat     2820

gatggtcgga atggggaaag caggaaagaa gcttttaatc gtgagagcaa gatggagccc     2880

aagatggaac ccaaagtgga cagcagcaag atggacaagg tggacagcaa gacagataag     2940

acagctgacg gctttgctgt cccagagccg cctaaacgca agaaaagtcg atgggacagt     3000

tagaggggat gtgctaaagc gtgaaatcag ttgtccttaa tttttagaaa gattttggta     3060

actaggtgtc tcagggctgg gttggggtcc aaagtgtaag gaccccctgc ccttagtgga     3120

gagctggagc ttggagacat taccccttca tcagaaggaa ttttcggatg ttttcttggg     3180

aagctgtttt ggtccttgga agcagtgaga gctgggaagc ttcttttggc tctaggtgag     3240

ttgtcatgtg ggtaagttga ggttatcttg ggataaaggg tcttctaggg cacaaaactc     3300

actctaggtt tatattgtat gtagcttata ttttttacta aggtgtcacc ttataagcat     3360

ctataaattg acttcttttt cttagttgta tggccaggca gtccccattt taggagttgg     3420

cttctgcaaa ttcaatccat tgagctaact gttggggagc aatttggtag ttgtagacat     3480

ttgcagggaa gggagatgtc tgattctaaa tgggagttga tgctcaggtc cccagccagg     3540

tttgcatcca gccctgagac atgtaggaaa cacctttcag acccaggctc tgaagattcc     3600

cagaagccac aaggattgaa gggaaaaggt gatcctggta actgttccag gattgctcca     3660

ggtttgagat ggtattgcta aatttaaaat taaacaagaa acccaacaac agcttttaaa     3720

gtgtcttcta tctcattgta ttttttttaa cttgccccaa tgatagaaaa gtcttttgct     3780

gaaatgattt tgatgatttt tgtttatcgt ttataaaaag gaaaagaaat atacaaactt     3840

tgacttttgt gactttgtga aggtttcttt aagatgtgca ttcctttctg cttgctctct     3900

agtaaatgtt ttactaccgg gaaaaaaaaa aaaaaaaaaa aaa                       3943


<210>  84
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Asn Trp Asn Lys Gly Gly Pro Gly Thr Lys Arg Gly Phe Gly Phe 
1               5                   10                  15      


Gly Gly Phe Ala Ile Ser Ala Gly Lys Lys Glu Glu Pro Lys Leu Pro 
            20                  25                  30          


Gln Gln Ser His Ser Ala Phe Gly Ala Thr Ser Ser Ser Ser Gly Phe 
        35                  40                  45              


Gly Lys Ser Ala Pro Pro Gln Leu Pro Ser Phe Tyr Lys Ile Gly Ser 
    50                  55                  60                  


Lys Arg Ala Asn Phe Asp Glu Glu Asn Ala Tyr Phe Glu Asp Glu Glu 
65                  70                  75                  80  


Glu Asp Ser Ser Asn Val Asp Leu Pro Tyr Ile Pro Ala Glu Asn Ser 
                85                  90                  95      


Pro Thr Arg Gln Gln Phe His Ser Lys Pro Val Asp Ser Asp Ser Asp 
            100                 105                 110         


Asp Asp Pro Leu Glu Ala Phe Met Ala Glu Val Glu Asp Gln Ala Ala 
        115                 120                 125             


Arg Asp Met Lys Arg Leu Glu Glu Lys Asp Lys Glu Arg Lys Asn Val 
    130                 135                 140                 


Lys Gly Ile Arg Asp Asp Ile Glu Glu Glu Asp Asp Gln Glu Ala Tyr 
145                 150                 155                 160 


Phe Arg Tyr Met Ala Glu Asn Pro Thr Ala Gly Val Val Gln Glu Glu 
                165                 170                 175     


Glu Glu Asp Asn Leu Glu Tyr Asp Ser Asp Gly Asn Pro Ile Ala Pro 
            180                 185                 190         


Thr Lys Lys Ile Ile Asp Pro Leu Pro Pro Ile Asp His Ser Glu Ile 
        195                 200                 205             


Asp Tyr Pro Pro Phe Glu Lys Asn Phe Tyr Asn Glu His Glu Glu Ile 
    210                 215                 220                 


Thr Asn Leu Thr Pro Gln Gln Leu Ile Asp Leu Arg His Lys Leu Asn 
225                 230                 235                 240 


Leu Arg Val Ser Gly Ala Ala Pro Pro Arg Pro Gly Ser Ser Phe Ala 
                245                 250                 255     


His Phe Gly Phe Asp Glu Gln Leu Met His Gln Ile Arg Lys Ser Glu 
            260                 265                 270         


Tyr Thr Gln Pro Thr Pro Ile Gln Cys Gln Gly Val Pro Val Ala Leu 
        275                 280                 285             


Ser Gly Arg Asp Met Ile Gly Ile Ala Lys Thr Gly Ser Gly Lys Thr 
    290                 295                 300                 


Ala Ala Phe Ile Trp Pro Met Leu Ile His Ile Met Asp Gln Lys Glu 
305                 310                 315                 320 


Leu Glu Pro Gly Asp Gly Pro Ile Ala Val Ile Val Cys Pro Thr Arg 
                325                 330                 335     


Glu Leu Cys Gln Gln Ile His Ala Glu Cys Lys Arg Phe Gly Lys Ala 
            340                 345                 350         


Tyr Asn Leu Arg Ser Val Ala Val Tyr Gly Gly Gly Ser Met Trp Glu 
        355                 360                 365             


Gln Ala Lys Ala Leu Gln Glu Gly Ala Glu Ile Val Val Cys Thr Pro 
    370                 375                 380                 


Gly Arg Leu Ile Asp His Val Lys Lys Lys Ala Thr Asn Leu Gln Arg 
385                 390                 395                 400 


Val Ser Tyr Leu Val Phe Asp Glu Ala Asp Arg Met Phe Asp Met Gly 
                405                 410                 415     


Phe Glu Tyr Gln Val Arg Ser Ile Ala Ser His Val Arg Pro Asp Arg 
            420                 425                 430         


Gln Thr Leu Leu Phe Ser Ala Thr Phe Arg Lys Lys Ile Glu Lys Leu 
        435                 440                 445             


Ala Arg Asp Ile Leu Ile Asp Pro Ile Arg Val Val Gln Gly Asp Ile 
    450                 455                 460                 


Gly Glu Ala Asn Glu Asp Val Thr Gln Ile Val Glu Ile Leu His Ser 
465                 470                 475                 480 


Gly Pro Ser Lys Trp Asn Trp Leu Thr Arg Arg Leu Val Glu Phe Thr 
                485                 490                 495     


Ser Ser Gly Ser Val Leu Leu Phe Val Thr Lys Lys Ala Asn Ala Glu 
            500                 505                 510         


Glu Leu Ala Asn Asn Leu Lys Gln Glu Gly His Asn Leu Gly Leu Leu 
        515                 520                 525             


His Gly Asp Met Asp Gln Ser Glu Arg Asn Lys Val Ile Ser Asp Phe 
    530                 535                 540                 


Lys Lys Lys Asp Ile Pro Val Leu Val Ala Thr Asp Val Ala Ala Arg 
545                 550                 555                 560 


Gly Leu Asp Ile Pro Ser Ile Lys Thr Val Ile Asn Tyr Asp Val Ala 
                565                 570                 575     


Arg Asp Ile Asp Thr His Thr His Arg Ile Gly Arg Thr Gly Arg Ala 
            580                 585                 590         


Gly Glu Lys Gly Val Ala Tyr Thr Leu Leu Thr Pro Lys Asp Ser Asn 
        595                 600                 605             


Phe Ala Gly Asp Leu Val Arg Asn Leu Glu Gly Ala Asn Gln His Val 
    610                 615                 620                 


Ser Lys Glu Leu Leu Asp Leu Ala Met Gln Asn Ala Trp Phe Arg Lys 
625                 630                 635                 640 


Ser Arg Phe Lys Gly Gly Lys Gly Lys Lys Leu Asn Ile Gly Gly Gly 
                645                 650                 655     


Gly Leu Gly Tyr Arg Glu Arg Pro Gly Leu Gly Ser Glu Asn Met Asp 
            660                 665                 670         


Arg Gly Asn Asn Asn Val Met Ser Asn Tyr Glu Ala Tyr Lys Pro Ser 
        675                 680                 685             


Thr Gly Ala Met Gly Asp Arg Leu Thr Ala Met Lys Ala Ala Phe Gln 
    690                 695                 700                 


Ser Gln Tyr Lys Ser His Phe Val Ala Ala Ser Leu Ser Asn Gln Lys 
705                 710                 715                 720 


Ala Gly Ser Ser Ala Ala Gly Ala Ser Gly Trp Thr Ser Ala Gly Ser 
                725                 730                 735     


Leu Asn Ser Val Pro Thr Asn Ser Ala Gln Gln Gly His Asn Ser Pro 
            740                 745                 750         


Asp Ser Pro Val Thr Ser Ala Ala Lys Gly Ile Pro Gly Phe Gly Asn 
        755                 760                 765             


Thr Gly Asn Ile Ser Gly Ala Pro Val Thr Tyr Pro Ser Ala Gly Ala 
    770                 775                 780                 


Gln Gly Val Asn Asn Thr Ala Ser Gly Asn Asn Ser Arg Glu Gly Thr 
785                 790                 795                 800 


Gly Gly Ser Asn Gly Lys Arg Glu Arg Tyr Thr Glu Asn Arg Gly Ser 
                805                 810                 815     


Ser Arg His Ser His Gly Glu Thr Gly Asn Arg His Ser Asp Ser Pro 
            820                 825                 830         


Arg His Gly Asp Gly Gly Arg His Gly Asp Gly Tyr Arg His Pro Glu 
        835                 840                 845             


Ser Ser Ser Arg His Thr Asp Gly His Arg His Gly Glu Asn Arg His 
    850                 855                 860                 


Gly Gly Ser Ala Gly Arg His Gly Glu Asn Arg Gly Ala Asn Asp Gly 
865                 870                 875                 880 


Arg Asn Gly Glu Ser Arg Lys Glu Ala Phe Asn Arg Glu Ser Lys Met 
                885                 890                 895     


Glu Pro Lys Met Glu Pro Lys Val Asp Ser Ser Lys Met Asp Lys Val 
            900                 905                 910         


Asp Ser Lys Thr Asp Lys Thr Ala Asp Gly Phe Ala Val Pro Glu Pro 
        915                 920                 925             


Pro Lys Arg Lys Lys Ser Arg Trp Asp Ser 
    930                 935             


<210>  85
<211>  13505
<212>  DNA
<213>  Homo sapiens

<400>  85
gttttgcctg cacgatgtcc agcaaagctg agaagaagca gcgattgagt ggccgaggaa       60

gctcccaggc aagctggtca gggcgggcca ctcgggctgc tgtggccaca caggagcagg      120

ggaatgcccc ggctgtcagt gagccagagc tgcaggctga gctccccaag gaggagcctg      180

agccacggtt ggagggacct caagcacaga gtgaagaatc agtggagccc gaggcagatg      240

tgaagcccct cttcctttcc cgagctgcgc tgacaggact ggcggatgca gtgtggacac      300

aggagcatga tgccattctg gaacactttg cccaggaccc tacagaatcc atcctcacca      360

tcttcattga cccttgtttt gggctgaagc tagagctggg catgcctgta cagacccaga      420

accagcttgt ctacttcatt cgccaagcac cagttcccat cacctgggag aacttcgagg      480

caactgtgca gtttgggacg gtgcggggcc cctatatccc ggccctgctt cggctgctcg      540

gtggagtctt tgcccctcag atctttgcaa acacaggctg gcctgagagc attagaaatc      600

attttgcttc tcatctgcac aagttcttgg cctgcctgac agacactcgg tacaaactgg      660

aggggcacac ggtcctctac atccctgcag aggccatgaa catgaagcct gagatggtga      720

taaaggacaa agagctggtg caacggctag agacctccat gatccactgg acccggcaga      780

taaaggagat gctcagtgcc caggagactg tggagacagg agaaaattta ggtcctctgg      840

aggagattga gttctggcgc aaccgatgca tggacctgtc tggcatcagt aagcagctgg      900

tgaagaaggg agtgaagcac gttgaatcca tcctgcacct tgccaagtcg tcctacttgg      960

cgccctttat gaaactggca cagcagatcc aggatggctc tcgtcaagca cagtcaaacc     1020

tgaccttttt gtcaatcctg aaggaacctt accaggagtt ggctttcatg aagcccaagg     1080

acatctctag caagctccct aagctgatca gtctcatccg catcatctgg gtcaactctc     1140

cccactacaa cactcgggag agactgacct cgctcttccg aaaggtatgt gactgtcagt     1200

atcacttcgc ccgctgggaa gatggcaagc agggtcccct tccttgcttc tttggtgccc     1260

aggggccaca gataacacgg aacttgctgg agattgagga catctttcat aaaaatctgc     1320

acacgctgcg agccgttcgc gggggtatcc tggatgtcaa gaacacctgt tggcatgaag     1380

actacaataa gttccgtgcc ggaatcaagg acctggaggt gatgacccag aacctgatca     1440

cctcagcctt cgagttggtg cgggacgtgc cgcacggcgt gcttctgctg gacaccttcc     1500

acaggcttgc ctcccgcgag gctatcaagc ggacttatga caagaaggcg gtggatctct     1560

acatgctgtt caatagcgag ctggccctgg tgaaccgtga acggaacaag aaatggccag     1620

acctggagcc ctacgtggcc cagtattccg gaaaggcgcg ctgggtgcac atcctccggc     1680

gtcgcatcga cagagtcatg acctgccttg ctggtgctca tttcctgccc cgtattggga     1740

ctggaaagga gagtgtgcac acctatcagc agatggtcca ggccattgat gagctggttc     1800

gaaaaacctt ccaagagtgg acatcaagtc tggacaagga ttgcattcgg cggttggata     1860

ccccattgct gcgaatcagc caggagaagg cgggcatgct ggatgtcaac tttgacaagt     1920

cccttctgat tctctttgcg gaaattgact actgggagcg gctgctgttt gagacgcccc     1980

attacgtggt gaacgtagct gagcgagccg aggacctgcg cattctgcgt gaaaatctgc     2040

tactcgttgc tagagactac aataggatta ttgccatgct gtccccagat gagcaggccc     2100

tattcaaaga gcgtattcgg ctcctggata agaagatcca cccgggactc aagaaactgc     2160

actgggcctt gaagggggcc agtgccttct tcatcacgga gtgccgtata catgccagca     2220

aggtgcagat gattgtgaat gagttcaagg catccactct gaccattggc tggcgagccc     2280

aagagatgtc agagaagctg ctggtacgca ttagtggcaa acgggtatac agggacctgg     2340

aatttgaaga ggaccaaaga gagcatcggg cagctgtaca gcagaaattg atgaacctgc     2400

accaggatgt ggtgaccatc atgaccaact cctatgaggt cttcaagaat gatggtcctg     2460

agattcagca gcagtggatg ctgtacatga ttcggctgga ccgcatgatg gaggatgccc     2520

tgcgcctgaa tgtgaagtgg tcactgctag aactatccaa ggctatcaac ggggatggaa     2580

agaccagccc aaacccactc ttccaagtcc ttgtcatttt gaagaatgat ctgcaaggaa     2640

gtgtggcaca ggtggaattc tcacccactc tgcagacttt ggcaggtgtg gtcaatgaca     2700

ttggcaacca cctcttttcc accatctctg tcttctgcca cctccctgac attctcacca     2760

agcgcaagtt acatcgtgaa cccatccaaa cagttgtgga gcaagatgag gacatcaaga     2820

agatccagac ccaaatcagc agcggcatga ctaacaacgc aagcctgctg cagaactacc     2880

tcaagacctg ggacatgtac cgggagatct gggagatcaa caaggactcc ttcattcatc     2940

gctaccagcg cctcaaccct cctgtctctt cttttgttgc cgacattgcc cgctacacgg     3000

aagttgctaa taacgtgcag aaggaggaga cagtcaccaa catccagttt gtgctgctgg     3060

actgttcgca cctcaagttc tccctggtgc agcactgcaa tgaatggcag aacaagttcg     3120

cgactctgct cagggagatg gctgctgggc gcctcctgga gctgcacacc tacctgaagg     3180

agaacgcaga gaaaatcagc cgccctccgc agacactgga ggaactgggg gtcagcttgc     3240

agctcgtgga tgccctgaag cacgacttgg ccaacgtgga gactcagatc cctcccatac     3300

acgagcaatt tgccattctt gaaaagtacg aggtgccagt cgaggacagt gtcctggaga     3360

tgctggacag tctcaacggg gagtgggttg tcttccaaca aactctgctg gacagtaagc     3420

aaatgctgaa gaaacacaag gagaaattca agacaggcct gatccactcg gcagatgact     3480

tcaagaagaa agcacataca cttctggaag atttcgaatt caaaggccat ttcaccagca     3540

acgtgggata catgtctgcc ttagaccaga ttacacaagt gcgggccatg ctgatggcca     3600

tgcgggaaga ggaaaatagt ctccgagcca acctgggcat cttcaagatc gagcagccac     3660

cctccaagga ccttcagaac ctggagaagg agctcgatgc cctccagcaa atctgggaga     3720

tcgcacgaga ctgggaggag aactggaatg agtggaagac tggccggttc ctgatcctgc     3780

agacggaaac catggagacc acggcccacg ggctgtttcg tcgcctcaca aaattagcca     3840

aagagtataa ggaccgaaac tgggaaatta ttgaaaccac tcgctcaaaa atagagcagt     3900

tcaagaggac catgcctctc atctcagacc tgcggaaccc tgcccttaga gagaggcact     3960

gggaccaggt ccgggatgag atccagcggg agtttgatca ggaatctgaa agcttcacct     4020

tggagcagat tgtggagctt gggatggatc agcatgtgga gaaaattggg gagatctctg     4080

cttcagcaac taaagagctg gctatagaag tggctttaca aaacattgcc aagacctggg     4140

atgtgactca gctcgacata gtaccctaca aggataaggg ccatcatcgg ctcagaggta     4200

cagaagaagt attccaggca ctggaagata accaggtagc tctgtctacc atgaaggcat     4260

cacgctttgt caaggccttt gagaaggatg tggaccactg ggaacgctgc ctctccctca     4320

ttttggaggt tattgagatg attctcacag tgcagcgtca gtggatgtac ttagagaata     4380

tcttcctagg agaagacatc cgcaagcagc tgcccaatga atcgacctta tttgaccagg     4440

tcaacagcaa ctggaaagcc atcatggaca ggatgaacaa ggacaacaat gctctccgga     4500

gcacccatca cccaggcctc ctggacacat tgatagaaat gaatacaatc ctggaagata     4560

ttcagaaatc tctggatatg tatttagaga ccaagcgaca tattttcccc cgcttctact     4620

tcttgtccaa tgatgacctg ctggagattc tgggccagtc ccgaaaccca gaggctgtgc     4680

agccacacct caaaaaatgc tttgacaaca tcaagttgct gagaatccag aaggttggag     4740

ggcccagcag caaatgggaa gctgtgggga tgttctcggg cgacggcgag tacattgact     4800

tcctccactc agtattttta gaaggccctg tggagtcctg gcttggcgat gtggaacaga     4860

ccatgagggt gaccctgcgg gaccttctcc ggaactgcca cctggccctc aggaagttcc     4920

tcaacaagag ggacaaatgg gtgaaggagt gggctggcca ggtggtgatc actgccagtc     4980

agatccagtg gacggctgat gtcaccaagt gcctgctgac agcgaaggag cgggcagaca     5040

agaaaatcct caaggtcatg aagaagaacc aggtgtcaat cctgaataag tattcagaag     5100

ccatcagggg gaacttgacc aagatcatgc ggcttaaaat tgtggctctg gtgacgatag     5160

aaattcatgc ccgggatgtg ttggagaagc tttacaagag tggcctcatg gatgtcaatt     5220

cctttgactg gctcagccaa cttcggttct actgggagaa ggatcttgat gactgtgtga     5280

tccgccagac caacacgcaa tttcagtata attatgagta cttgggtaac tcgggccggc     5340

tcgtcatcac ccccctgacg gacaggtgtt acatgacact gaccacggca ttgcacctgc     5400

accgaggggg ctcccccaaa ggccctgcag gcacaggcaa gaccgagacc gtcaaggacc     5460

tgggcaaggc cctgggcata tatgtcattg tggtcaactg ctctgagggc ctggactaca     5520

agtccatggg ccgaatgtac tcaggtctgg cccagactgg agcttggggc tgctttgatg     5580

agtttaaccg catcaacatc gaggtgctgt cagtggtggc ccaccagatc ctgtgcatcc     5640

tgtctgccct ggctgccggc ctcacccatt tccattttga tggctttgaa ataaatctgg     5700

tgtggtcctg tgggatcttc attaccatga atcctggcta tgctggccgc acagagcttc     5760

ccgaaaatct taaatccatg ttccgcccaa ttgccatggt ggtgcctgac tccaccctca     5820

ttgcagaaat cattctcttt ggagagggct ttggcaactg caagattctg gccaagaagg     5880

tgtacacact ctactcactg gctgtgcagc agctgtccag acaggaccac tatgactttg     5940

gcctgcgtgc cctcacctcc cttctgcgct atgctggcaa gaagcgccgc ctacagccgg     6000

atctgactga tgaagaggtt ctgctgctct caatgagaga tatgaacatc gccaagctca     6060

cttcagttga tgcacccctg ttcaatgcca tcgtgcaaga tctgtttccc aacattgagc     6120

tgcctgtcat tgactatggc aagctgcggg agaccgttga gcaggagatt cgagacatgg     6180

gcctgcaaag cacgccgttc accctcacca aggttttcca gttgtatgaa accaagaact     6240

cccgccactc caccatgatc gtgggctgca cgggcagcgg caagactgcc tcatggcgca     6300

ttctacaggc ctccctgtcc tctctgtgcc gcgccggaga ccctaacttc aacattgtta     6360

gagagttccc tttgaacccc aaggcattgt ccctagggga actgtatggg gaatatgacc     6420

tcagcaccaa tgaatggaca gatggcatct tgtccagtgt catgcggacg gcatgtgcag     6480

atgagaaacc cgacgagaag tggatcctgt tcgatggccc cgtggacaca ctgtggatcg     6540

agaacatgaa ctccgtcatg gacgataaca aggtgttgac cctcatcaac ggcgagcgca     6600

tcgcgatgcc cgagcaggtg tctctcctgt ttgaagtgga ggacctggca atggcctctc     6660

cggccactgt atcccgctgc gggatggtct acactgacta cgctgacctg ggctggaagc     6720

cctatgttca gtcatggctg gagaagaggc caaaggctga ggtggagccc cttcaacgca     6780

tgttcgaaaa gctcatcaac aagatgctgg cctttaagaa ggacaactgc aaggagctgg     6840

tgcccctgcc cgagtacagc ggtatcacct ccctctgcaa gctgtactct gccctggcca     6900

cgccagagaa tggggtgaac ccagctgacg gcgagaacta tgtcaccatg gtagagatga     6960

catttgtgtt cagcatgatc tggtctgtgt gtgcctctgt ggatgaggag ggccggaaga     7020

ggatcgacag ctacctccga gagatcgagg gctcctttcc caataaggac acggtatatg     7080

agtattttgt ggaccccaaa atacggagtt ggacatcatt tgaggacaag ctccctaaga     7140

gttggcgcta ccctccaaac gcccccttct ataagatcat ggtgcccacc gtcgacactg     7200

ttcgctacaa ctacctggtg agcagcttgg tggccaacca gaatcccatt ctgctggtgg     7260

gtcccgtggg gactgggaag acctccatcg cccagagcgt tctgcagtcc ctgccctcca     7320

gccagtggtc ggtgctcgtt gtcaacatgt ccgcacagac cacatccaat aacgtgcaga     7380

gcatcattga gagcagggtt gagaagcgaa ccaagggtgt ctacgtgcca ttcgggggca     7440

aaagcatgat cacctttatg gatgacctaa atatgcccgc taaggacatg tttgggtccc     7500

agccacccct ggagctgatc cgcctctgga ttgactatgg cttctggtat gaccgtacga     7560

agcagaccat caagtacatt cgagaaatgt tcctgatggc tgccatgggc ccccctgggg     7620

gtggacggac tgtcatctcc ccaaggctac ggagtcgctt caacattatc aacatgacct     7680

tccccacaaa gtcccagatc atccgcatat tcggcaccat gatcaatcag aagcttcagg     7740

actttgagga agaggtgaag cccattggga acgtggtgac agaggccacc ctggacatgt     7800

acaacaccgt ggtacagcgc ttcctgccca cgcccaccaa gatgcattac ctcttcaacc     7860

ttcgagacat ctccaaggtg ttccagggca tgcttagagc caacaaggac ttccatgata     7920

ccaagtccag catcacacgg ctctggatcc atgaatgttt cagagtcttc tctgaccggc     7980

tggttgatgc ggcagacaca gaagccttca tgggcatcat aagcgacaag ctcggctcct     8040

tctttgacct cacatttcat catctctgtc ccagcaagcg tcctcctatc tttggggatt     8100

tcctgaagga gcccaaggtg tatgaagacc tcacggatct gacagtgctg aagacagtca     8160

tggagacagc tctaaatgag tataacctgt caccctctgt cgtgcccatg cagctagtgc     8220

tcttccgaga ggctattgaa cacatcacac ggatcgtgcg ggtcattgga cagcctcggg     8280

gcaacatgct cctggtgggt atcgggggca gcggacgcca gagtctggcc cgcctggctt     8340

catccatctg cgactacacc accttccaga tcgaggtcac caaacattat cggaagcagg     8400

agttccgaga tgatatcaag cgtctgtatc gccaggctgg ggtggagctc aagaccacgt     8460

ccttcatttt tgtggacacc caaatagctg atgagtcctt cctagaggac atcaacaaca     8520

tcctcagctc aggcgaggtg cccaatctct acaagcctga tgaatttgaa gagatccagt     8580

cgcatatcat agaccaggcc cgggtggagc aggtgcctga gtcatcggac agcctcttcg     8640

cctacctcat tgaacgcgtg cagaacaacc tgcacatcgt gctctgcctc agccccatgg     8700

gggatccctt caggaactgg atccgccagt acccagcctt ggtgaactgc acaaccatca     8760

actggttctc agagtggccc caagaggccc tgctcgaggt ggctgagaag tgcctcatag     8820

gagtagacct gggaactcag gagaatatcc acaggaaggt ggcccagatc tttgtcacta     8880

tgcactggtc agtagctcag tattcccaga agatgctgtt ggaactgcgg agacacaact     8940

atgtcacacc caccaaatac ctggaactcc tgtctggata taagaagttg ctgggagaaa     9000

aacggcagga gctgctggcc caagccaata aactgcggac aggcttgttc aagatcgacg     9060

aaactaggga aaaggtgcaa gtgatgtcgt tggagctgga ggatgccaag aagaaggtgg     9120

ctgagttcca gaagcagtgt gaggagtacc tggtcatcat tgtgcagcag aagcgggagg     9180

cagatgagca gcagaaggcc gtaacagcca acagtgaaaa gattgcagtt gaggaaatca     9240

agtgtcaggc actggctgac aatgcccaga aagatctaga agaggcactg cccgccctgg     9300

aagaggccat gcgggccctg gagtctctga acaagaagga tataggagag atcaagtctt     9360

atggacggcc cccagcccaa gtggagatag tgatgcaggc agttatgatt cttcgaggca     9420

acgagcccac atgggcagag gccaagaggc agctagggga acagaacttc atcaagtcac     9480

tgatcaactt tgataaagac aatatctcag ataaggttct gaagaagatt ggggcctact     9540

gcgcccagcc tgacttccag cctgatatca tcggccgcgt ctccctggct gccaagtccc     9600

tctgcatgtg ggtgcgggcc atggagctgt atgggcggct atatcgggtg gtggagccca     9660

agcgaatccg aatgaacgct gccttggctc agcttcggga gaagcaagcc gcgctcgctg     9720

aggcccagga gaagctgcgg gaggtagctg agaaactgga gatgctaaag aaacagtatg     9780

atgagaagct ggcacagaag gaggagcttc gcaagaagtc tgaagagatg gagctgaagc     9840

tggagcgagc tgggatgctc gtgtcggggt tggctggcga gaaggccaga tgggaggaga     9900

cagtccaggg cctggaggag gacctgggct acctggtggg ggactgtctc ctggcagctg     9960

ccttcctgtc ctacatggga cccttcctga ccaactaccg ggatgagatt gtcaaccaaa    10020

tctggatcgg gaagatctgg gagcttcagg ttccttgctc cccttctttc gccatcgata    10080

acttcctgtg caatcctacc aaagtccggg actggaacat ccaagggttg ccctcagacg    10140

ccttctccac tgagaatggc atcatcgtca cccgaggcaa caggtgggca ctgatgatcg    10200

accctcaggc ccaggccctg aaatggatta agaacatgga aggaggccag ggcctgaaga    10260

tcatcgacct gcagatgagc gattacctgc gaatcctaga acacgccatt cactttggat    10320

acccggtgct acttcagaac gtgcaggaat atctggaccc cacactgaac cccatgctca    10380

acaaatctgt agcccgaatc ggtggtcggc tgttgatgcg cattggcgat aaggaggtgg    10440

aatataatac caatttccgt ttctacatca ccaccaagct ctccaacccc cactacagcc    10500

cagagacctc agccaagacc accatcgtca actttgctgt taaagaacag ggcctggagg    10560

cccagctgct gggcattgtg gtgcggaagg agcggcctga gctggaggag cagaaggact    10620

cactggtcat caacatcgcg gctggtaaaa ggaagctcaa ggagctggag gatgagatcc    10680

tgcggctgct gaatgaggcc accggctccc tgctggatga tgtgcagctg gtgaacacgc    10740

tgcatacctc caagatcaca gccacagagg tgactgagca gctggagacc agtgagacca    10800

cagagatcaa cactgacttg gcgcgggagg cttaccgccc atgcgcccag cgggcatcaa    10860

tcctgttctt cgtgctcaat gatatgggct gcatcgaccc catgtaccag ttctcactgg    10920

atgcctacat cagcctcttt attctcagca ttgacaaaag ccaccgcagc aataagctgg    10980

aggaccgcat tgactacctg aatgactacc acacctacgc tgtctacagg tacacctgcc    11040

gtaccctttt cgaacgccac aaactactat tcagttttca tatgtgtgcc aaaatcttgg    11100

agacttctgg caagctcaac atggatgaat acaacttctt tctacgtggg ggtgtggtct    11160

tggatcggga gggccaaatg gacaatccat gtagtagctg gcttgcagat gcctactggg    11220

ataacatcac agagctagac aaactgacca acttccacgg actcatgaac tcctttgagc    11280

agtaccctcg tgactggcac ctgtggtata ccaatgctgc cccggagaag gcgatgctgc    11340

caggtgagtg ggaaaatgcc tgcaatgaaa tgcaacggat gctgatcgtt cgctccctgc    11400

gccaggaccg cgtggccttc tgcgtgacct ccttcatcat caccaacctt ggctcccgct    11460

tcatcgagcc gcctgtgctg aatatgaagt cggtgctgga ggattcaacc ccacgatccc    11520

cactcgtgtt catcctgtcc cctggtgtgg accccaccag tgccctgctg cagctggcag    11580

agcacatggg catggcccag cgcttccacg ccctgtccct gggccagggc caggccccca    11640

tcgctgctcg gctcctccga gagggtgtga ctcagggaca ctgggtgttc ctggcaaact    11700

gccacctgtc actgtcttgg atgcctaatc tggacaagct ggtggagcag ctgcaggtgg    11760

aggatcctca tccatccttc cgcctctggc tcagctccat cccccaccca gacttcccta    11820

tctcaatctt gcaggtcagc atcaagatga ccacagagcc accaaagggc ctaaaggcca    11880

acatgacacg tctttaccaa ctgatgtcag aaccacagtt ttcccgctgc tccaaacctg    11940

ccaaatataa gaagctgctg ttttcactct gtttcttcca ctctgtgtta cttgaacgca    12000

aaaagttcct gcagcttggc tggaacatca tctatggctt caatgactcc gactttgagg    12060

tgtcagaaaa cttgctgagc ctctatctcg atgagtacga ggagacacct tgggacgcac    12120

ttaagtacct cattgccggc atcaactatg gtggacatgt cacagatgac tgggaccggc    12180

gcctgctgac cacctacatc aatgattatt tctgtgacca gtctctatca actcccttcc    12240

accggttgtc agcactggag acttatttca tccccaagga tggcagcctc gcttcttaca    12300

aggaatacat cagcttattg cctggcatgg acccccctga ggcctttggc cagcacccca    12360

atgctgatgt ggcctctcag atcactgagg cacaaaccct ctttgatact ttgctttcct    12420

tgcaacctca gattacaccc accagggctg gaggccagac ccgggaagag aaggtccttg    12480

agttggccgc tgatgtgaag cagaagatcc ctgaaatgat cgactatgag gggactcaaa    12540

aactgctagc tctcgacccc tcccccctca atgtggtcct tctgcaggag atccagagat    12600

acaacacact gatgcagacc atcctgttct cactgacaga cctagagaaa ggcatccagg    12660

gtctcatcgt catgtctaca agcctggaag agattttcaa ttgcatcttt gatgcccatg    12720

ttcctccgct ctggggaaag gcatacccct cacaaaagcc attggctgcc tggacccggg    12780

acttggccat gcgtgtggag cagtttgagc tgtgggccag ccgggcccgg cctcctgtga    12840

tcttctggtt gtctggtttc acctttccca ctggcttcct cactgctgtg ctgcagtctt    12900

cagctcgcca aaacaacgtt tcagtggaca gcctctcctg ggagtttatc gtttccactg    12960

tggatgacag caacctagtg tatcccccca aggatggtgt ctgggtccgg ggcctgtacc    13020

tggaaggtgc tggctgggac cggaagaact cctgcttggt ggaggcagag cccatgcagc    13080

ttgtctgcct catgcccacg atccacttcc ggcctgcaga gagccgcaag aagagcgcca    13140

agggcatgta ctcctgcccc tgctattact atcccaaccg ggcaggcagc tcagaccgag    13200

cctcctttgt catcggcatt gacctgcggt ctggggccat gacacctgat cattggatca    13260

agaggggcac tgctctactc atgagcctgg acagctgaga cctcctcctc ttctccgctt    13320

gagagagagg gtcagggact ccaggagcta agacagatgt tgcacctagg actgaggccg    13380

gacctcactc agactttgac cttggccgaa tttgtgtgat gtggccctgg agatacctag    13440

ttgtgttagc cataaaagtg aaagagttgt attggagctc agtgctgtaa aacacccgcg    13500

acaac                                                                13505


<210>  86
<211>  4427
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ser Ser Lys Ala Glu Lys Lys Gln Arg Leu Ser Gly Arg Gly Ser 
1               5                   10                  15      


Ser Gln Ala Ser Trp Ser Gly Arg Ala Thr Arg Ala Ala Val Ala Thr 
            20                  25                  30          


Gln Glu Gln Gly Asn Ala Pro Ala Val Ser Glu Pro Glu Leu Gln Ala 
        35                  40                  45              


Glu Leu Pro Lys Glu Glu Pro Glu Pro Arg Leu Glu Gly Pro Gln Ala 
    50                  55                  60                  


Gln Ser Glu Glu Ser Val Glu Pro Glu Ala Asp Val Lys Pro Leu Phe 
65                  70                  75                  80  


Leu Ser Arg Ala Ala Leu Thr Gly Leu Ala Asp Ala Val Trp Thr Gln 
                85                  90                  95      


Glu His Asp Ala Ile Leu Glu His Phe Ala Gln Asp Pro Thr Glu Ser 
            100                 105                 110         


Ile Leu Thr Ile Phe Ile Asp Pro Cys Phe Gly Leu Lys Leu Glu Leu 
        115                 120                 125             


Gly Met Pro Val Gln Thr Gln Asn Gln Leu Val Tyr Phe Ile Arg Gln 
    130                 135                 140                 


Ala Pro Val Pro Ile Thr Trp Glu Asn Phe Glu Ala Thr Val Gln Phe 
145                 150                 155                 160 


Gly Thr Val Arg Gly Pro Tyr Ile Pro Ala Leu Leu Arg Leu Leu Gly 
                165                 170                 175     


Gly Val Phe Ala Pro Gln Ile Phe Ala Asn Thr Gly Trp Pro Glu Ser 
            180                 185                 190         


Ile Arg Asn His Phe Ala Ser His Leu His Lys Phe Leu Ala Cys Leu 
        195                 200                 205             


Thr Asp Thr Arg Tyr Lys Leu Glu Gly His Thr Val Leu Tyr Ile Pro 
    210                 215                 220                 


Ala Glu Ala Met Asn Met Lys Pro Glu Met Val Ile Lys Asp Lys Glu 
225                 230                 235                 240 


Leu Val Gln Arg Leu Glu Thr Ser Met Ile His Trp Thr Arg Gln Ile 
                245                 250                 255     


Lys Glu Met Leu Ser Ala Gln Glu Thr Val Glu Thr Gly Glu Asn Leu 
            260                 265                 270         


Gly Pro Leu Glu Glu Ile Glu Phe Trp Arg Asn Arg Cys Met Asp Leu 
        275                 280                 285             


Ser Gly Ile Ser Lys Gln Leu Val Lys Lys Gly Val Lys His Val Glu 
    290                 295                 300                 


Ser Ile Leu His Leu Ala Lys Ser Ser Tyr Leu Ala Pro Phe Met Lys 
305                 310                 315                 320 


Leu Ala Gln Gln Ile Gln Asp Gly Ser Arg Gln Ala Gln Ser Asn Leu 
                325                 330                 335     


Thr Phe Leu Ser Ile Leu Lys Glu Pro Tyr Gln Glu Leu Ala Phe Met 
            340                 345                 350         


Lys Pro Lys Asp Ile Ser Ser Lys Leu Pro Lys Leu Ile Ser Leu Ile 
        355                 360                 365             


Arg Ile Ile Trp Val Asn Ser Pro His Tyr Asn Thr Arg Glu Arg Leu 
    370                 375                 380                 


Thr Ser Leu Phe Arg Lys Val Cys Asp Cys Gln Tyr His Phe Ala Arg 
385                 390                 395                 400 


Trp Glu Asp Gly Lys Gln Gly Pro Leu Pro Cys Phe Phe Gly Ala Gln 
                405                 410                 415     


Gly Pro Gln Ile Thr Arg Asn Leu Leu Glu Ile Glu Asp Ile Phe His 
            420                 425                 430         


Lys Asn Leu His Thr Leu Arg Ala Val Arg Gly Gly Ile Leu Asp Val 
        435                 440                 445             


Lys Asn Thr Cys Trp His Glu Asp Tyr Asn Lys Phe Arg Ala Gly Ile 
    450                 455                 460                 


Lys Asp Leu Glu Val Met Thr Gln Asn Leu Ile Thr Ser Ala Phe Glu 
465                 470                 475                 480 


Leu Val Arg Asp Val Pro His Gly Val Leu Leu Leu Asp Thr Phe His 
                485                 490                 495     


Arg Leu Ala Ser Arg Glu Ala Ile Lys Arg Thr Tyr Asp Lys Lys Ala 
            500                 505                 510         


Val Asp Leu Tyr Met Leu Phe Asn Ser Glu Leu Ala Leu Val Asn Arg 
        515                 520                 525             


Glu Arg Asn Lys Lys Trp Pro Asp Leu Glu Pro Tyr Val Ala Gln Tyr 
    530                 535                 540                 


Ser Gly Lys Ala Arg Trp Val His Ile Leu Arg Arg Arg Ile Asp Arg 
545                 550                 555                 560 


Val Met Thr Cys Leu Ala Gly Ala His Phe Leu Pro Arg Ile Gly Thr 
                565                 570                 575     


Gly Lys Glu Ser Val His Thr Tyr Gln Gln Met Val Gln Ala Ile Asp 
            580                 585                 590         


Glu Leu Val Arg Lys Thr Phe Gln Glu Trp Thr Ser Ser Leu Asp Lys 
        595                 600                 605             


Asp Cys Ile Arg Arg Leu Asp Thr Pro Leu Leu Arg Ile Ser Gln Glu 
    610                 615                 620                 


Lys Ala Gly Met Leu Asp Val Asn Phe Asp Lys Ser Leu Leu Ile Leu 
625                 630                 635                 640 


Phe Ala Glu Ile Asp Tyr Trp Glu Arg Leu Leu Phe Glu Thr Pro His 
                645                 650                 655     


Tyr Val Val Asn Val Ala Glu Arg Ala Glu Asp Leu Arg Ile Leu Arg 
            660                 665                 670         


Glu Asn Leu Leu Leu Val Ala Arg Asp Tyr Asn Arg Ile Ile Ala Met 
        675                 680                 685             


Leu Ser Pro Asp Glu Gln Ala Leu Phe Lys Glu Arg Ile Arg Leu Leu 
    690                 695                 700                 


Asp Lys Lys Ile His Pro Gly Leu Lys Lys Leu His Trp Ala Leu Lys 
705                 710                 715                 720 


Gly Ala Ser Ala Phe Phe Ile Thr Glu Cys Arg Ile His Ala Ser Lys 
                725                 730                 735     


Val Gln Met Ile Val Asn Glu Phe Lys Ala Ser Thr Leu Thr Ile Gly 
            740                 745                 750         


Trp Arg Ala Gln Glu Met Ser Glu Lys Leu Leu Val Arg Ile Ser Gly 
        755                 760                 765             


Lys Arg Val Tyr Arg Asp Leu Glu Phe Glu Glu Asp Gln Arg Glu His 
    770                 775                 780                 


Arg Ala Ala Val Gln Gln Lys Leu Met Asn Leu His Gln Asp Val Val 
785                 790                 795                 800 


Thr Ile Met Thr Asn Ser Tyr Glu Val Phe Lys Asn Asp Gly Pro Glu 
                805                 810                 815     


Ile Gln Gln Gln Trp Met Leu Tyr Met Ile Arg Leu Asp Arg Met Met 
            820                 825                 830         


Glu Asp Ala Leu Arg Leu Asn Val Lys Trp Ser Leu Leu Glu Leu Ser 
        835                 840                 845             


Lys Ala Ile Asn Gly Asp Gly Lys Thr Ser Pro Asn Pro Leu Phe Gln 
    850                 855                 860                 


Val Leu Val Ile Leu Lys Asn Asp Leu Gln Gly Ser Val Ala Gln Val 
865                 870                 875                 880 


Glu Phe Ser Pro Thr Leu Gln Thr Leu Ala Gly Val Val Asn Asp Ile 
                885                 890                 895     


Gly Asn His Leu Phe Ser Thr Ile Ser Val Phe Cys His Leu Pro Asp 
            900                 905                 910         


Ile Leu Thr Lys Arg Lys Leu His Arg Glu Pro Ile Gln Thr Val Val 
        915                 920                 925             


Glu Gln Asp Glu Asp Ile Lys Lys Ile Gln Thr Gln Ile Ser Ser Gly 
    930                 935                 940                 


Met Thr Asn Asn Ala Ser Leu Leu Gln Asn Tyr Leu Lys Thr Trp Asp 
945                 950                 955                 960 


Met Tyr Arg Glu Ile Trp Glu Ile Asn Lys Asp Ser Phe Ile His Arg 
                965                 970                 975     


Tyr Gln Arg Leu Asn Pro Pro Val Ser Ser Phe Val Ala Asp Ile Ala 
            980                 985                 990         


Arg Tyr Thr Glu Val Ala Asn Asn  Val Gln Lys Glu Glu  Thr Val Thr 
        995                 1000                 1005             


Asn Ile  Gln Phe Val Leu Leu  Asp Cys Ser His Leu  Lys Phe Ser 
    1010                 1015                 1020             


Leu Val  Gln His Cys Asn Glu  Trp Gln Asn Lys Phe  Ala Thr Leu 
    1025                 1030                 1035             


Leu Arg  Glu Met Ala Ala Gly  Arg Leu Leu Glu Leu  His Thr Tyr 
    1040                 1045                 1050             


Leu Lys  Glu Asn Ala Glu Lys  Ile Ser Arg Pro Pro  Gln Thr Leu 
    1055                 1060                 1065             


Glu Glu  Leu Gly Val Ser Leu  Gln Leu Val Asp Ala  Leu Lys His 
    1070                 1075                 1080             


Asp Leu  Ala Asn Val Glu Thr  Gln Ile Pro Pro Ile  His Glu Gln 
    1085                 1090                 1095             


Phe Ala  Ile Leu Glu Lys Tyr  Glu Val Pro Val Glu  Asp Ser Val 
    1100                 1105                 1110             


Leu Glu  Met Leu Asp Ser Leu  Asn Gly Glu Trp Val  Val Phe Gln 
    1115                 1120                 1125             


Gln Thr  Leu Leu Asp Ser Lys  Gln Met Leu Lys Lys  His Lys Glu 
    1130                 1135                 1140             


Lys Phe  Lys Thr Gly Leu Ile  His Ser Ala Asp Asp  Phe Lys Lys 
    1145                 1150                 1155             


Lys Ala  His Thr Leu Leu Glu  Asp Phe Glu Phe Lys  Gly His Phe 
    1160                 1165                 1170             


Thr Ser  Asn Val Gly Tyr Met  Ser Ala Leu Asp Gln  Ile Thr Gln 
    1175                 1180                 1185             


Val Arg  Ala Met Leu Met Ala  Met Arg Glu Glu Glu  Asn Ser Leu 
    1190                 1195                 1200             


Arg Ala  Asn Leu Gly Ile Phe  Lys Ile Glu Gln Pro  Pro Ser Lys 
    1205                 1210                 1215             


Asp Leu  Gln Asn Leu Glu Lys  Glu Leu Asp Ala Leu  Gln Gln Ile 
    1220                 1225                 1230             


Trp Glu  Ile Ala Arg Asp Trp  Glu Glu Asn Trp Asn  Glu Trp Lys 
    1235                 1240                 1245             


Thr Gly  Arg Phe Leu Ile Leu  Gln Thr Glu Thr Met  Glu Thr Thr 
    1250                 1255                 1260             


Ala His  Gly Leu Phe Arg Arg  Leu Thr Lys Leu Ala  Lys Glu Tyr 
    1265                 1270                 1275             


Lys Asp  Arg Asn Trp Glu Ile  Ile Glu Thr Thr Arg  Ser Lys Ile 
    1280                 1285                 1290             


Glu Gln  Phe Lys Arg Thr Met  Pro Leu Ile Ser Asp  Leu Arg Asn 
    1295                 1300                 1305             


Pro Ala  Leu Arg Glu Arg His  Trp Asp Gln Val Arg  Asp Glu Ile 
    1310                 1315                 1320             


Gln Arg  Glu Phe Asp Gln Glu  Ser Glu Ser Phe Thr  Leu Glu Gln 
    1325                 1330                 1335             


Ile Val  Glu Leu Gly Met Asp  Gln His Val Glu Lys  Ile Gly Glu 
    1340                 1345                 1350             


Ile Ser  Ala Ser Ala Thr Lys  Glu Leu Ala Ile Glu  Val Ala Leu 
    1355                 1360                 1365             


Gln Asn  Ile Ala Lys Thr Trp  Asp Val Thr Gln Leu  Asp Ile Val 
    1370                 1375                 1380             


Pro Tyr  Lys Asp Lys Gly His  His Arg Leu Arg Gly  Thr Glu Glu 
    1385                 1390                 1395             


Val Phe  Gln Ala Leu Glu Asp  Asn Gln Val Ala Leu  Ser Thr Met 
    1400                 1405                 1410             


Lys Ala  Ser Arg Phe Val Lys  Ala Phe Glu Lys Asp  Val Asp His 
    1415                 1420                 1425             


Trp Glu  Arg Cys Leu Ser Leu  Ile Leu Glu Val Ile  Glu Met Ile 
    1430                 1435                 1440             


Leu Thr  Val Gln Arg Gln Trp  Met Tyr Leu Glu Asn  Ile Phe Leu 
    1445                 1450                 1455             


Gly Glu  Asp Ile Arg Lys Gln  Leu Pro Asn Glu Ser  Thr Leu Phe 
    1460                 1465                 1470             


Asp Gln  Val Asn Ser Asn Trp  Lys Ala Ile Met Asp  Arg Met Asn 
    1475                 1480                 1485             


Lys Asp  Asn Asn Ala Leu Arg  Ser Thr His His Pro  Gly Leu Leu 
    1490                 1495                 1500             


Asp Thr  Leu Ile Glu Met Asn  Thr Ile Leu Glu Asp  Ile Gln Lys 
    1505                 1510                 1515             


Ser Leu  Asp Met Tyr Leu Glu  Thr Lys Arg His Ile  Phe Pro Arg 
    1520                 1525                 1530             


Phe Tyr  Phe Leu Ser Asn Asp  Asp Leu Leu Glu Ile  Leu Gly Gln 
    1535                 1540                 1545             


Ser Arg  Asn Pro Glu Ala Val  Gln Pro His Leu Lys  Lys Cys Phe 
    1550                 1555                 1560             


Asp Asn  Ile Lys Leu Leu Arg  Ile Gln Lys Val Gly  Gly Pro Ser 
    1565                 1570                 1575             


Ser Lys  Trp Glu Ala Val Gly  Met Phe Ser Gly Asp  Gly Glu Tyr 
    1580                 1585                 1590             


Ile Asp  Phe Leu His Ser Val  Phe Leu Glu Gly Pro  Val Glu Ser 
    1595                 1600                 1605             


Trp Leu  Gly Asp Val Glu Gln  Thr Met Arg Val Thr  Leu Arg Asp 
    1610                 1615                 1620             


Leu Leu  Arg Asn Cys His Leu  Ala Leu Arg Lys Phe  Leu Asn Lys 
    1625                 1630                 1635             


Arg Asp  Lys Trp Val Lys Glu  Trp Ala Gly Gln Val  Val Ile Thr 
    1640                 1645                 1650             


Ala Ser  Gln Ile Gln Trp Thr  Ala Asp Val Thr Lys  Cys Leu Leu 
    1655                 1660                 1665             


Thr Ala  Lys Glu Arg Ala Asp  Lys Lys Ile Leu Lys  Val Met Lys 
    1670                 1675                 1680             


Lys Asn  Gln Val Ser Ile Leu  Asn Lys Tyr Ser Glu  Ala Ile Arg 
    1685                 1690                 1695             


Gly Asn  Leu Thr Lys Ile Met  Arg Leu Lys Ile Val  Ala Leu Val 
    1700                 1705                 1710             


Thr Ile  Glu Ile His Ala Arg  Asp Val Leu Glu Lys  Leu Tyr Lys 
    1715                 1720                 1725             


Ser Gly  Leu Met Asp Val Asn  Ser Phe Asp Trp Leu  Ser Gln Leu 
    1730                 1735                 1740             


Arg Phe  Tyr Trp Glu Lys Asp  Leu Asp Asp Cys Val  Ile Arg Gln 
    1745                 1750                 1755             


Thr Asn  Thr Gln Phe Gln Tyr  Asn Tyr Glu Tyr Leu  Gly Asn Ser 
    1760                 1765                 1770             


Gly Arg  Leu Val Ile Thr Pro  Leu Thr Asp Arg Cys  Tyr Met Thr 
    1775                 1780                 1785             


Leu Thr  Thr Ala Leu His Leu  His Arg Gly Gly Ser  Pro Lys Gly 
    1790                 1795                 1800             


Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Val Lys Asp  Leu Gly Lys 
    1805                 1810                 1815             


Ala Leu  Gly Ile Tyr Val Ile  Val Val Asn Cys Ser  Glu Gly Leu 
    1820                 1825                 1830             


Asp Tyr  Lys Ser Met Gly Arg  Met Tyr Ser Gly Leu  Ala Gln Thr 
    1835                 1840                 1845             


Gly Ala  Trp Gly Cys Phe Asp  Glu Phe Asn Arg Ile  Asn Ile Glu 
    1850                 1855                 1860             


Val Leu  Ser Val Val Ala His  Gln Ile Leu Cys Ile  Leu Ser Ala 
    1865                 1870                 1875             


Leu Ala  Ala Gly Leu Thr His  Phe His Phe Asp Gly  Phe Glu Ile 
    1880                 1885                 1890             


Asn Leu  Val Trp Ser Cys Gly  Ile Phe Ile Thr Met  Asn Pro Gly 
    1895                 1900                 1905             


Tyr Ala  Gly Arg Thr Glu Leu  Pro Glu Asn Leu Lys  Ser Met Phe 
    1910                 1915                 1920             


Arg Pro  Ile Ala Met Val Val  Pro Asp Ser Thr Leu  Ile Ala Glu 
    1925                 1930                 1935             


Ile Ile  Leu Phe Gly Glu Gly  Phe Gly Asn Cys Lys  Ile Leu Ala 
    1940                 1945                 1950             


Lys Lys  Val Tyr Thr Leu Tyr  Ser Leu Ala Val Gln  Gln Leu Ser 
    1955                 1960                 1965             


Arg Gln  Asp His Tyr Asp Phe  Gly Leu Arg Ala Leu  Thr Ser Leu 
    1970                 1975                 1980             


Leu Arg  Tyr Ala Gly Lys Lys  Arg Arg Leu Gln Pro  Asp Leu Thr 
    1985                 1990                 1995             


Asp Glu  Glu Val Leu Leu Leu  Ser Met Arg Asp Met  Asn Ile Ala 
    2000                 2005                 2010             


Lys Leu  Thr Ser Val Asp Ala  Pro Leu Phe Asn Ala  Ile Val Gln 
    2015                 2020                 2025             


Asp Leu  Phe Pro Asn Ile Glu  Leu Pro Val Ile Asp  Tyr Gly Lys 
    2030                 2035                 2040             


Leu Arg  Glu Thr Val Glu Gln  Glu Ile Arg Asp Met  Gly Leu Gln 
    2045                 2050                 2055             


Ser Thr  Pro Phe Thr Leu Thr  Lys Val Phe Gln Leu  Tyr Glu Thr 
    2060                 2065                 2070             


Lys Asn  Ser Arg His Ser Thr  Met Ile Val Gly Cys  Thr Gly Ser 
    2075                 2080                 2085             


Gly Lys  Thr Ala Ser Trp Arg  Ile Leu Gln Ala Ser  Leu Ser Ser 
    2090                 2095                 2100             


Leu Cys  Arg Ala Gly Asp Pro  Asn Phe Asn Ile Val  Arg Glu Phe 
    2105                 2110                 2115             


Pro Leu  Asn Pro Lys Ala Leu  Ser Leu Gly Glu Leu  Tyr Gly Glu 
    2120                 2125                 2130             


Tyr Asp  Leu Ser Thr Asn Glu  Trp Thr Asp Gly Ile  Leu Ser Ser 
    2135                 2140                 2145             


Val Met  Arg Thr Ala Cys Ala  Asp Glu Lys Pro Asp  Glu Lys Trp 
    2150                 2155                 2160             


Ile Leu  Phe Asp Gly Pro Val  Asp Thr Leu Trp Ile  Glu Asn Met 
    2165                 2170                 2175             


Asn Ser  Val Met Asp Asp Asn  Lys Val Leu Thr Leu  Ile Asn Gly 
    2180                 2185                 2190             


Glu Arg  Ile Ala Met Pro Glu  Gln Val Ser Leu Leu  Phe Glu Val 
    2195                 2200                 2205             


Glu Asp  Leu Ala Met Ala Ser  Pro Ala Thr Val Ser  Arg Cys Gly 
    2210                 2215                 2220             


Met Val  Tyr Thr Asp Tyr Ala  Asp Leu Gly Trp Lys  Pro Tyr Val 
    2225                 2230                 2235             


Gln Ser  Trp Leu Glu Lys Arg  Pro Lys Ala Glu Val  Glu Pro Leu 
    2240                 2245                 2250             


Gln Arg  Met Phe Glu Lys Leu  Ile Asn Lys Met Leu  Ala Phe Lys 
    2255                 2260                 2265             


Lys Asp  Asn Cys Lys Glu Leu  Val Pro Leu Pro Glu  Tyr Ser Gly 
    2270                 2275                 2280             


Ile Thr  Ser Leu Cys Lys Leu  Tyr Ser Ala Leu Ala  Thr Pro Glu 
    2285                 2290                 2295             


Asn Gly  Val Asn Pro Ala Asp  Gly Glu Asn Tyr Val  Thr Met Val 
    2300                 2305                 2310             


Glu Met  Thr Phe Val Phe Ser  Met Ile Trp Ser Val  Cys Ala Ser 
    2315                 2320                 2325             


Val Asp  Glu Glu Gly Arg Lys  Arg Ile Asp Ser Tyr  Leu Arg Glu 
    2330                 2335                 2340             


Ile Glu  Gly Ser Phe Pro Asn  Lys Asp Thr Val Tyr  Glu Tyr Phe 
    2345                 2350                 2355             


Val Asp  Pro Lys Ile Arg Ser  Trp Thr Ser Phe Glu  Asp Lys Leu 
    2360                 2365                 2370             


Pro Lys  Ser Trp Arg Tyr Pro  Pro Asn Ala Pro Phe  Tyr Lys Ile 
    2375                 2380                 2385             


Met Val  Pro Thr Val Asp Thr  Val Arg Tyr Asn Tyr  Leu Val Ser 
    2390                 2395                 2400             


Ser Leu  Val Ala Asn Gln Asn  Pro Ile Leu Leu Val  Gly Pro Val 
    2405                 2410                 2415             


Gly Thr  Gly Lys Thr Ser Ile  Ala Gln Ser Val Leu  Gln Ser Leu 
    2420                 2425                 2430             


Pro Ser  Ser Gln Trp Ser Val  Leu Val Val Asn Met  Ser Ala Gln 
    2435                 2440                 2445             


Thr Thr  Ser Asn Asn Val Gln  Ser Ile Ile Glu Ser  Arg Val Glu 
    2450                 2455                 2460             


Lys Arg  Thr Lys Gly Val Tyr  Val Pro Phe Gly Gly  Lys Ser Met 
    2465                 2470                 2475             


Ile Thr  Phe Met Asp Asp Leu  Asn Met Pro Ala Lys  Asp Met Phe 
    2480                 2485                 2490             


Gly Ser  Gln Pro Pro Leu Glu  Leu Ile Arg Leu Trp  Ile Asp Tyr 
    2495                 2500                 2505             


Gly Phe  Trp Tyr Asp Arg Thr  Lys Gln Thr Ile Lys  Tyr Ile Arg 
    2510                 2515                 2520             


Glu Met  Phe Leu Met Ala Ala  Met Gly Pro Pro Gly  Gly Gly Arg 
    2525                 2530                 2535             


Thr Val  Ile Ser Pro Arg Leu  Arg Ser Arg Phe Asn  Ile Ile Asn 
    2540                 2545                 2550             


Met Thr  Phe Pro Thr Lys Ser  Gln Ile Ile Arg Ile  Phe Gly Thr 
    2555                 2560                 2565             


Met Ile  Asn Gln Lys Leu Gln  Asp Phe Glu Glu Glu  Val Lys Pro 
    2570                 2575                 2580             


Ile Gly  Asn Val Val Thr Glu  Ala Thr Leu Asp Met  Tyr Asn Thr 
    2585                 2590                 2595             


Val Val  Gln Arg Phe Leu Pro  Thr Pro Thr Lys Met  His Tyr Leu 
    2600                 2605                 2610             


Phe Asn  Leu Arg Asp Ile Ser  Lys Val Phe Gln Gly  Met Leu Arg 
    2615                 2620                 2625             


Ala Asn  Lys Asp Phe His Asp  Thr Lys Ser Ser Ile  Thr Arg Leu 
    2630                 2635                 2640             


Trp Ile  His Glu Cys Phe Arg  Val Phe Ser Asp Arg  Leu Val Asp 
    2645                 2650                 2655             


Ala Ala  Asp Thr Glu Ala Phe  Met Gly Ile Ile Ser  Asp Lys Leu 
    2660                 2665                 2670             


Gly Ser  Phe Phe Asp Leu Thr  Phe His His Leu Cys  Pro Ser Lys 
    2675                 2680                 2685             


Arg Pro  Pro Ile Phe Gly Asp  Phe Leu Lys Glu Pro  Lys Val Tyr 
    2690                 2695                 2700             


Glu Asp  Leu Thr Asp Leu Thr  Val Leu Lys Thr Val  Met Glu Thr 
    2705                 2710                 2715             


Ala Leu  Asn Glu Tyr Asn Leu  Ser Pro Ser Val Val  Pro Met Gln 
    2720                 2725                 2730             


Leu Val  Leu Phe Arg Glu Ala  Ile Glu His Ile Thr  Arg Ile Val 
    2735                 2740                 2745             


Arg Val  Ile Gly Gln Pro Arg  Gly Asn Met Leu Leu  Val Gly Ile 
    2750                 2755                 2760             


Gly Gly  Ser Gly Arg Gln Ser  Leu Ala Arg Leu Ala  Ser Ser Ile 
    2765                 2770                 2775             


Cys Asp  Tyr Thr Thr Phe Gln  Ile Glu Val Thr Lys  His Tyr Arg 
    2780                 2785                 2790             


Lys Gln  Glu Phe Arg Asp Asp  Ile Lys Arg Leu Tyr  Arg Gln Ala 
    2795                 2800                 2805             


Gly Val  Glu Leu Lys Thr Thr  Ser Phe Ile Phe Val  Asp Thr Gln 
    2810                 2815                 2820             


Ile Ala  Asp Glu Ser Phe Leu  Glu Asp Ile Asn Asn  Ile Leu Ser 
    2825                 2830                 2835             


Ser Gly  Glu Val Pro Asn Leu  Tyr Lys Pro Asp Glu  Phe Glu Glu 
    2840                 2845                 2850             


Ile Gln  Ser His Ile Ile Asp  Gln Ala Arg Val Glu  Gln Val Pro 
    2855                 2860                 2865             


Glu Ser  Ser Asp Ser Leu Phe  Ala Tyr Leu Ile Glu  Arg Val Gln 
    2870                 2875                 2880             


Asn Asn  Leu His Ile Val Leu  Cys Leu Ser Pro Met  Gly Asp Pro 
    2885                 2890                 2895             


Phe Arg  Asn Trp Ile Arg Gln  Tyr Pro Ala Leu Val  Asn Cys Thr 
    2900                 2905                 2910             


Thr Ile  Asn Trp Phe Ser Glu  Trp Pro Gln Glu Ala  Leu Leu Glu 
    2915                 2920                 2925             


Val Ala  Glu Lys Cys Leu Ile  Gly Val Asp Leu Gly  Thr Gln Glu 
    2930                 2935                 2940             


Asn Ile  His Arg Lys Val Ala  Gln Ile Phe Val Thr  Met His Trp 
    2945                 2950                 2955             


Ser Val  Ala Gln Tyr Ser Gln  Lys Met Leu Leu Glu  Leu Arg Arg 
    2960                 2965                 2970             


His Asn  Tyr Val Thr Pro Thr  Lys Tyr Leu Glu Leu  Leu Ser Gly 
    2975                 2980                 2985             


Tyr Lys  Lys Leu Leu Gly Glu  Lys Arg Gln Glu Leu  Leu Ala Gln 
    2990                 2995                 3000             


Ala Asn  Lys Leu Arg Thr Gly  Leu Phe Lys Ile Asp  Glu Thr Arg 
    3005                 3010                 3015             


Glu Lys  Val Gln Val Met Ser  Leu Glu Leu Glu Asp  Ala Lys Lys 
    3020                 3025                 3030             


Lys Val  Ala Glu Phe Gln Lys  Gln Cys Glu Glu Tyr  Leu Val Ile 
    3035                 3040                 3045             


Ile Val  Gln Gln Lys Arg Glu  Ala Asp Glu Gln Gln  Lys Ala Val 
    3050                 3055                 3060             


Thr Ala  Asn Ser Glu Lys Ile  Ala Val Glu Glu Ile  Lys Cys Gln 
    3065                 3070                 3075             


Ala Leu  Ala Asp Asn Ala Gln  Lys Asp Leu Glu Glu  Ala Leu Pro 
    3080                 3085                 3090             


Ala Leu  Glu Glu Ala Met Arg  Ala Leu Glu Ser Leu  Asn Lys Lys 
    3095                 3100                 3105             


Asp Ile  Gly Glu Ile Lys Ser  Tyr Gly Arg Pro Pro  Ala Gln Val 
    3110                 3115                 3120             


Glu Ile  Val Met Gln Ala Val  Met Ile Leu Arg Gly  Asn Glu Pro 
    3125                 3130                 3135             


Thr Trp  Ala Glu Ala Lys Arg  Gln Leu Gly Glu Gln  Asn Phe Ile 
    3140                 3145                 3150             


Lys Ser  Leu Ile Asn Phe Asp  Lys Asp Asn Ile Ser  Asp Lys Val 
    3155                 3160                 3165             


Leu Lys  Lys Ile Gly Ala Tyr  Cys Ala Gln Pro Asp  Phe Gln Pro 
    3170                 3175                 3180             


Asp Ile  Ile Gly Arg Val Ser  Leu Ala Ala Lys Ser  Leu Cys Met 
    3185                 3190                 3195             


Trp Val  Arg Ala Met Glu Leu  Tyr Gly Arg Leu Tyr  Arg Val Val 
    3200                 3205                 3210             


Glu Pro  Lys Arg Ile Arg Met  Asn Ala Ala Leu Ala  Gln Leu Arg 
    3215                 3220                 3225             


Glu Lys  Gln Ala Ala Leu Ala  Glu Ala Gln Glu Lys  Leu Arg Glu 
    3230                 3235                 3240             


Val Ala  Glu Lys Leu Glu Met  Leu Lys Lys Gln Tyr  Asp Glu Lys 
    3245                 3250                 3255             


Leu Ala  Gln Lys Glu Glu Leu  Arg Lys Lys Ser Glu  Glu Met Glu 
    3260                 3265                 3270             


Leu Lys  Leu Glu Arg Ala Gly  Met Leu Val Ser Gly  Leu Ala Gly 
    3275                 3280                 3285             


Glu Lys  Ala Arg Trp Glu Glu  Thr Val Gln Gly Leu  Glu Glu Asp 
    3290                 3295                 3300             


Leu Gly  Tyr Leu Val Gly Asp  Cys Leu Leu Ala Ala  Ala Phe Leu 
    3305                 3310                 3315             


Ser Tyr  Met Gly Pro Phe Leu  Thr Asn Tyr Arg Asp  Glu Ile Val 
    3320                 3325                 3330             


Asn Gln  Ile Trp Ile Gly Lys  Ile Trp Glu Leu Gln  Val Pro Cys 
    3335                 3340                 3345             


Ser Pro  Ser Phe Ala Ile Asp  Asn Phe Leu Cys Asn  Pro Thr Lys 
    3350                 3355                 3360             


Val Arg  Asp Trp Asn Ile Gln  Gly Leu Pro Ser Asp  Ala Phe Ser 
    3365                 3370                 3375             


Thr Glu  Asn Gly Ile Ile Val  Thr Arg Gly Asn Arg  Trp Ala Leu 
    3380                 3385                 3390             


Met Ile  Asp Pro Gln Ala Gln  Ala Leu Lys Trp Ile  Lys Asn Met 
    3395                 3400                 3405             


Glu Gly  Gly Gln Gly Leu Lys  Ile Ile Asp Leu Gln  Met Ser Asp 
    3410                 3415                 3420             


Tyr Leu  Arg Ile Leu Glu His  Ala Ile His Phe Gly  Tyr Pro Val 
    3425                 3430                 3435             


Leu Leu  Gln Asn Val Gln Glu  Tyr Leu Asp Pro Thr  Leu Asn Pro 
    3440                 3445                 3450             


Met Leu  Asn Lys Ser Val Ala  Arg Ile Gly Gly Arg  Leu Leu Met 
    3455                 3460                 3465             


Arg Ile  Gly Asp Lys Glu Val  Glu Tyr Asn Thr Asn  Phe Arg Phe 
    3470                 3475                 3480             


Tyr Ile  Thr Thr Lys Leu Ser  Asn Pro His Tyr Ser  Pro Glu Thr 
    3485                 3490                 3495             


Ser Ala  Lys Thr Thr Ile Val  Asn Phe Ala Val Lys  Glu Gln Gly 
    3500                 3505                 3510             


Leu Glu  Ala Gln Leu Leu Gly  Ile Val Val Arg Lys  Glu Arg Pro 
    3515                 3520                 3525             


Glu Leu  Glu Glu Gln Lys Asp  Ser Leu Val Ile Asn  Ile Ala Ala 
    3530                 3535                 3540             


Gly Lys  Arg Lys Leu Lys Glu  Leu Glu Asp Glu Ile  Leu Arg Leu 
    3545                 3550                 3555             


Leu Asn  Glu Ala Thr Gly Ser  Leu Leu Asp Asp Val  Gln Leu Val 
    3560                 3565                 3570             


Asn Thr  Leu His Thr Ser Lys  Ile Thr Ala Thr Glu  Val Thr Glu 
    3575                 3580                 3585             


Gln Leu  Glu Thr Ser Glu Thr  Thr Glu Ile Asn Thr  Asp Leu Ala 
    3590                 3595                 3600             


Arg Glu  Ala Tyr Arg Pro Cys  Ala Gln Arg Ala Ser  Ile Leu Phe 
    3605                 3610                 3615             


Phe Val  Leu Asn Asp Met Gly  Cys Ile Asp Pro Met  Tyr Gln Phe 
    3620                 3625                 3630             


Ser Leu  Asp Ala Tyr Ile Ser  Leu Phe Ile Leu Ser  Ile Asp Lys 
    3635                 3640                 3645             


Ser His  Arg Ser Asn Lys Leu  Glu Asp Arg Ile Asp  Tyr Leu Asn 
    3650                 3655                 3660             


Asp Tyr  His Thr Tyr Ala Val  Tyr Arg Tyr Thr Cys  Arg Thr Leu 
    3665                 3670                 3675             


Phe Glu  Arg His Lys Leu Leu  Phe Ser Phe His Met  Cys Ala Lys 
    3680                 3685                 3690             


Ile Leu  Glu Thr Ser Gly Lys  Leu Asn Met Asp Glu  Tyr Asn Phe 
    3695                 3700                 3705             


Phe Leu  Arg Gly Gly Val Val  Leu Asp Arg Glu Gly  Gln Met Asp 
    3710                 3715                 3720             


Asn Pro  Cys Ser Ser Trp Leu  Ala Asp Ala Tyr Trp  Asp Asn Ile 
    3725                 3730                 3735             


Thr Glu  Leu Asp Lys Leu Thr  Asn Phe His Gly Leu  Met Asn Ser 
    3740                 3745                 3750             


Phe Glu  Gln Tyr Pro Arg Asp  Trp His Leu Trp Tyr  Thr Asn Ala 
    3755                 3760                 3765             


Ala Pro  Glu Lys Ala Met Leu  Pro Gly Glu Trp Glu  Asn Ala Cys 
    3770                 3775                 3780             


Asn Glu  Met Gln Arg Met Leu  Ile Val Arg Ser Leu  Arg Gln Asp 
    3785                 3790                 3795             


Arg Val  Ala Phe Cys Val Thr  Ser Phe Ile Ile Thr  Asn Leu Gly 
    3800                 3805                 3810             


Ser Arg  Phe Ile Glu Pro Pro  Val Leu Asn Met Lys  Ser Val Leu 
    3815                 3820                 3825             


Glu Asp  Ser Thr Pro Arg Ser  Pro Leu Val Phe Ile  Leu Ser Pro 
    3830                 3835                 3840             


Gly Val  Asp Pro Thr Ser Ala  Leu Leu Gln Leu Ala  Glu His Met 
    3845                 3850                 3855             


Gly Met  Ala Gln Arg Phe His  Ala Leu Ser Leu Gly  Gln Gly Gln 
    3860                 3865                 3870             


Ala Pro  Ile Ala Ala Arg Leu  Leu Arg Glu Gly Val  Thr Gln Gly 
    3875                 3880                 3885             


His Trp  Val Phe Leu Ala Asn  Cys His Leu Ser Leu  Ser Trp Met 
    3890                 3895                 3900             


Pro Asn  Leu Asp Lys Leu Val  Glu Gln Leu Gln Val  Glu Asp Pro 
    3905                 3910                 3915             


His Pro  Ser Phe Arg Leu Trp  Leu Ser Ser Ile Pro  His Pro Asp 
    3920                 3925                 3930             


Phe Pro  Ile Ser Ile Leu Gln  Val Ser Ile Lys Met  Thr Thr Glu 
    3935                 3940                 3945             


Pro Pro  Lys Gly Leu Lys Ala  Asn Met Thr Arg Leu  Tyr Gln Leu 
    3950                 3955                 3960             


Met Ser  Glu Pro Gln Phe Ser  Arg Cys Ser Lys Pro  Ala Lys Tyr 
    3965                 3970                 3975             


Lys Lys  Leu Leu Phe Ser Leu  Cys Phe Phe His Ser  Val Leu Leu 
    3980                 3985                 3990             


Glu Arg  Lys Lys Phe Leu Gln  Leu Gly Trp Asn Ile  Ile Tyr Gly 
    3995                 4000                 4005             


Phe Asn  Asp Ser Asp Phe Glu  Val Ser Glu Asn Leu  Leu Ser Leu 
    4010                 4015                 4020             


Tyr Leu  Asp Glu Tyr Glu Glu  Thr Pro Trp Asp Ala  Leu Lys Tyr 
    4025                 4030                 4035             


Leu Ile  Ala Gly Ile Asn Tyr  Gly Gly His Val Thr  Asp Asp Trp 
    4040                 4045                 4050             


Asp Arg  Arg Leu Leu Thr Thr  Tyr Ile Asn Asp Tyr  Phe Cys Asp 
    4055                 4060                 4065             


Gln Ser  Leu Ser Thr Pro Phe  His Arg Leu Ser Ala  Leu Glu Thr 
    4070                 4075                 4080             


Tyr Phe  Ile Pro Lys Asp Gly  Ser Leu Ala Ser Tyr  Lys Glu Tyr 
    4085                 4090                 4095             


Ile Ser  Leu Leu Pro Gly Met  Asp Pro Pro Glu Ala  Phe Gly Gln 
    4100                 4105                 4110             


His Pro  Asn Ala Asp Val Ala  Ser Gln Ile Thr Glu  Ala Gln Thr 
    4115                 4120                 4125             


Leu Phe  Asp Thr Leu Leu Ser  Leu Gln Pro Gln Ile  Thr Pro Thr 
    4130                 4135                 4140             


Arg Ala  Gly Gly Gln Thr Arg  Glu Glu Lys Val Leu  Glu Leu Ala 
    4145                 4150                 4155             


Ala Asp  Val Lys Gln Lys Ile  Pro Glu Met Ile Asp  Tyr Glu Gly 
    4160                 4165                 4170             


Thr Gln  Lys Leu Leu Ala Leu  Asp Pro Ser Pro Leu  Asn Val Val 
    4175                 4180                 4185             


Leu Leu  Gln Glu Ile Gln Arg  Tyr Asn Thr Leu Met  Gln Thr Ile 
    4190                 4195                 4200             


Leu Phe  Ser Leu Thr Asp Leu  Glu Lys Gly Ile Gln  Gly Leu Ile 
    4205                 4210                 4215             


Val Met  Ser Thr Ser Leu Glu  Glu Ile Phe Asn Cys  Ile Phe Asp 
    4220                 4225                 4230             


Ala His  Val Pro Pro Leu Trp  Gly Lys Ala Tyr Pro  Ser Gln Lys 
    4235                 4240                 4245             


Pro Leu  Ala Ala Trp Thr Arg  Asp Leu Ala Met Arg  Val Glu Gln 
    4250                 4255                 4260             


Phe Glu  Leu Trp Ala Ser Arg  Ala Arg Pro Pro Val  Ile Phe Trp 
    4265                 4270                 4275             


Leu Ser  Gly Phe Thr Phe Pro  Thr Gly Phe Leu Thr  Ala Val Leu 
    4280                 4285                 4290             


Gln Ser  Ser Ala Arg Gln Asn  Asn Val Ser Val Asp  Ser Leu Ser 
    4295                 4300                 4305             


Trp Glu  Phe Ile Val Ser Thr  Val Asp Asp Ser Asn  Leu Val Tyr 
    4310                 4315                 4320             


Pro Pro  Lys Asp Gly Val Trp  Val Arg Gly Leu Tyr  Leu Glu Gly 
    4325                 4330                 4335             


Ala Gly  Trp Asp Arg Lys Asn  Ser Cys Leu Val Glu  Ala Glu Pro 
    4340                 4345                 4350             


Met Gln  Leu Val Cys Leu Met  Pro Thr Ile His Phe  Arg Pro Ala 
    4355                 4360                 4365             


Glu Ser  Arg Lys Lys Ser Ala  Lys Gly Met Tyr Ser  Cys Pro Cys 
    4370                 4375                 4380             


Tyr Tyr  Tyr Pro Asn Arg Ala  Gly Ser Ser Asp Arg  Ala Ser Phe 
    4385                 4390                 4395             


Val Ile  Gly Ile Asp Leu Arg  Ser Gly Ala Met Thr  Pro Asp His 
    4400                 4405                 4410             


Trp Ile  Lys Arg Gly Thr Ala  Leu Leu Met Ser Leu  Asp Ser 
    4415                 4420                 4425         


<210>  87
<211>  2545
<212>  DNA
<213>  Homo sapiens

<400>  87
actcattcac ataaaacgct gcgcggccgg cggaatcccc ggcttctagg gcggcgagcg       60

gccgggctgg ctatcgagcg agcggggcgg gaacgcggag ttgcgccgcc gctcgggcgc      120

cgggctccgt cgcggccgca gccccgcggg tcgccctccc gtgcctcgcc cgcggacacc      180

ctggccgtgg acaccctggc cgtgggcacc cgcggggcgc gcggcgcggg gccgctggcc      240

ggcggcggcg gcggcatgaa ggtcacgtcg ctcgacgggc gccagctgcg caagatgctc      300

cgcaaggagg cggcggcgcg ctgcgtggtg ctcgactgcc ggccctatct ggccttcgct      360

gcctcgaacg tgcgcggctc gctcaacgtc aacctcaact cggtggtgct gcggcgggcc      420

cggggcggcg cggtgtcggc gcgctacgtg ctgcccgacg aggcggcgcg cgcgcggctc      480

ctgcaggagg gcggcggcgg cgtcgcggcc gtggtggtgc tggaccaggg cagccgccac      540

tggcagaagc tgcgagagga gagcgccgcg cgtgtcgtcc tcacctcgct actcgcttgc      600

ctacccgccg gcccgcgggt ctacttcctc aaagggggat atgagacttt ctactcggaa      660

tatcctgagt gttgcgtgga tgtaaaaccc atttcacaag agaagattga gagtgagaga      720

gccctcatca gccagtgtgg aaaaccagtg gtaaatgtca gctacaggcc agcttatgac      780

cagggtggcc cagttgaaat ccttcccttc ctctaccttg gaagtgccta ccatgcatcc      840

aagtgcgagt tcctcgccaa cctgcacatc acagccctgc tgaatgtctc ccgacggacc      900

tccgaggcct gcgcgaccca cctacactac aaatggatcc ctgtggaaga cagccacacg      960

gctgacatta gctcccactt tcaagaagca atagacttca ttgactgtgt cagggaaaag     1020

ggaggcaagg tcctggtcca ctgtgaggct gggatctccc gttcacccac catctgcatg     1080

gcttacctta tgaagaccaa gcagttccgc ctgaaggagg ccttcgatta catcaagcag     1140

aggaggagca tggtctcgcc caactttggc ttcatgggcc agctcctgca gtacgaatct     1200

gagatcctgc cctccacgcc caacccccag cctccctcct gccaagggga ggcagcaggc     1260

tcttcactga taggccattt gcagacactg agccctgaca tgcagggtgc ctactgcaca     1320

ttccctgcct cggtgctggc accggtgcct acccactcaa cagtctcaga gctcagcaga     1380

agccctgtgg caacggccac atcctgctaa aactgggatg gaggaatcgg cccagcccca     1440

agagcaactg tgatttttgt ttttaagact catggacatt tcatacctgt gcaatactga     1500

agacctcatt ctgtcatgct gccccagtga gatagtgagt ggtcaccagg cttgcaaatg     1560

aacttcagac ggacctcagg gtaggttctc gggactgaag gaaggccaag ccattacggg     1620

agcacagcat gtgctgacta ctgtacttcc agacccctgc cctcttggga ctgcccagtc     1680

cttgcacctc agagttcgcc ttttcatttc aagcataagg caataaatac ctgcagcaac     1740

gtgggagaaa gaagttgctg gaccaggaga aaaggcagtt atgaagccaa ttcattttga     1800

aggaagcaca atttccacct tattttttga actttggcag tttcaatgtc tgtctctgtt     1860

gcttcggggc ataagctgat caccgtctag ttgggaaagt aaccctacag ggtttgtagg     1920

gacatgatca gcatcctgat ttgaaccctg aaatgttgtg tagacaccct cttgggtcca     1980

atgaggtagt tggttgaagt agcaagatgt tggcttttct ggattttttt tgccatgggt     2040

tcttcactga ccttggactt tggcatgatt cttagtcata cttgaacttg tctcattcca     2100

cctcttctca gagcaactct tcctttggga aaagagttct tcagatcata gaccaaaaaa     2160

gtcatacctt cgaggtggta gcagtagatt ccaggaggag aagggtactt gctaggtatc     2220

ctgggtcagt ggcggtgcaa actggtttcc tcagctgcct gtccttctgt gtgcttatgt     2280

ctcttgtgac aattgttttc ctccctgccc ctggaggttg tcttcaagct gtggacttct     2340

gggatttgca gattttgcaa cgtggtacta cttttttttt ctttttgtct gttagttatt     2400

tctccagggg aaaaggcaat aattttctaa gacccgtgtg aatgtgaaga aaagcagtat     2460

gttactggtt gttgttgttg ttcttgtttt ttatagtgta aaataaaaat agtaaaagga     2520

gaaaagcaaa aaaaaaaaaa aaaaa                                           2545


<210>  88
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
1               5                   10                  15      


Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
            20                  25                  30          


Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
        35                  40                  45              


Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
    50                  55                  60                  


Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                85                  90                  95      


Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
            100                 105                 110         


Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
        115                 120                 125             


Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
    130                 135                 140                 


Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
145                 150                 155                 160 


Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                165                 170                 175     


Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
            180                 185                 190         


His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
        195                 200                 205             


Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Ala Thr His Leu His 
    210                 215                 220                 


Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
225                 230                 235                 240 


His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                245                 250                 255     


Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
            260                 265                 270         


Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
        275                 280                 285             


Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
    290                 295                 300                 


Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
305                 310                 315                 320 


Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                325                 330                 335     


Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
            340                 345                 350         


Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
        355                 360                 365             


Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
    370                 375                 380                 


<210>  89
<211>  1397
<212>  DNA
<213>  Homo sapiens

<400>  89
gaagcggaag tcccaatcaa aagttgagca gtagctgtga gttgctggcg ctggagcgat       60

tcggtggcac gtggagccac ggcgtgggag tagggggctg aaggcaggca gcagcggcca      120

gggccgccct ctgctagccg cttgggtctc gggatacccc gtttcttcct gtaggtgtgg      180

gacgtgcgtg cggcgagatg gacactcccc cgctctcgga ttcggagtcg gaatccgatg      240

aatcccttgt cacagacaga gagttgcagg atgcgttttc ccgagggctt ctgaagccag      300

gcctcaatgt cgtgctagag gggccgaaga aggccgtgaa cgacgtgaat ggcctgaagc      360

aatgtttggc agaattcaag cgggatctgg aatgggttga aaggctcgat gtgacactgg      420

gtccggtacc ggagatcggt ggatctgagg cgccagcacc tcagaacaag gaccagaaag      480

ctgttgatcc agaagacgac ttccagcgag agatgagttt ctatcgccaa gcccaggccg      540

cagtgcttgc agtcttaccc cgcctccatc agctcaaagt ccctacgaag cgacccactg      600

attattttgc ggaaatggcc aaatctgatc tgcagatgca gaagattcga cagaagctgc      660

agactaaaca ggctgccatg gagaggtctg aaaaagctaa gcaactgcga gcacttagga      720

aatacgggaa gaaggtgcaa acggaggttc ttcagaagag gcagcaggag aaagcccata      780

tgatgaatgc tattaagaaa tatcagaaag gcttctctga taaactggat ttccttgagg      840

gagatcagaa acctctggca cagcgcaaga aggcaggagc caaaggccag cagatgagga      900

aggggcccag tgctaaacga cggtataaaa accagaagtt tggttttggt ggaaagaaga      960

aaggctcaaa gtggaacact cgggagagct atgatgatgt atctagcttc cgggccaaga     1020

cagctcatgg cagaggcctc aagaggcctg gcaagaaagg gtcaaataag agacctggaa     1080

aacgaacaag agagaagatg aagaacagaa cacactaaat agcatctttg aatacaaaga     1140

accaagaaaa aggaatgaag actcgcaatt tcacgacaca ctttgatccc ttctgttggt     1200

gtcatgttgt aaacatttct ttcaataaac taaagaaaaa ttattaaagg aacacatacc     1260

tttggttaaa tagtctagac taaaagattg agaagttact ttccattgct atctattgat     1320

aatttagaca ttgagttcaa attgccttca ttttatgata aataatgatt taactgacac     1380

cttctcaaaa aaaaaaa                                                    1397


<210>  90
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Asp Thr Pro Pro Leu Ser Asp Ser Glu Ser Glu Ser Asp Glu Ser 
1               5                   10                  15      


Leu Val Thr Asp Arg Glu Leu Gln Asp Ala Phe Ser Arg Gly Leu Leu 
            20                  25                  30          


Lys Pro Gly Leu Asn Val Val Leu Glu Gly Pro Lys Lys Ala Val Asn 
        35                  40                  45              


Asp Val Asn Gly Leu Lys Gln Cys Leu Ala Glu Phe Lys Arg Asp Leu 
    50                  55                  60                  


Glu Trp Val Glu Arg Leu Asp Val Thr Leu Gly Pro Val Pro Glu Ile 
65                  70                  75                  80  


Gly Gly Ser Glu Ala Pro Ala Pro Gln Asn Lys Asp Gln Lys Ala Val 
                85                  90                  95      


Asp Pro Glu Asp Asp Phe Gln Arg Glu Met Ser Phe Tyr Arg Gln Ala 
            100                 105                 110         


Gln Ala Ala Val Leu Ala Val Leu Pro Arg Leu His Gln Leu Lys Val 
        115                 120                 125             


Pro Thr Lys Arg Pro Thr Asp Tyr Phe Ala Glu Met Ala Lys Ser Asp 
    130                 135                 140                 


Leu Gln Met Gln Lys Ile Arg Gln Lys Leu Gln Thr Lys Gln Ala Ala 
145                 150                 155                 160 


Met Glu Arg Ser Glu Lys Ala Lys Gln Leu Arg Ala Leu Arg Lys Tyr 
                165                 170                 175     


Gly Lys Lys Val Gln Thr Glu Val Leu Gln Lys Arg Gln Gln Glu Lys 
            180                 185                 190         


Ala His Met Met Asn Ala Ile Lys Lys Tyr Gln Lys Gly Phe Ser Asp 
        195                 200                 205             


Lys Leu Asp Phe Leu Glu Gly Asp Gln Lys Pro Leu Ala Gln Arg Lys 
    210                 215                 220                 


Lys Ala Gly Ala Lys Gly Gln Gln Met Arg Lys Gly Pro Ser Ala Lys 
225                 230                 235                 240 


Arg Arg Tyr Lys Asn Gln Lys Phe Gly Phe Gly Gly Lys Lys Lys Gly 
                245                 250                 255     


Ser Lys Trp Asn Thr Arg Glu Ser Tyr Asp Asp Val Ser Ser Phe Arg 
            260                 265                 270         


Ala Lys Thr Ala His Gly Arg Gly Leu Lys Arg Pro Gly Lys Lys Gly 
        275                 280                 285             


Ser Asn Lys Arg Pro Gly Lys Arg Thr Arg Glu Lys Met Lys Asn Arg 
    290                 295                 300                 


Thr His 
305     


<210>  91
<211>  3528
<212>  DNA
<213>  Homo sapiens

<400>  91
ctttttcgca acgggtttgc cgccagaaca caggtgtcgt gaaaactacc cctaaaagcc       60

aaaatgggaa aggaaaagac tcatatcaac attgtcgtca ttggacacgt agattcgggc      120

aagtccacca ctactggcca tctgatctat aaatgcggtg gcatcgacaa aagaaccatt      180

gaaaaatttg agaaggaggc tgctgagatg ggaaagggct ccttcaagta tgcctgggtc      240

ttggataaac tgaaagctga gcgtgaacgt ggtatcacca ttgatatctc cttgtggaaa      300

tttgagacca gcaagtacta tgtgactatc attgatgccc caggacacag agactttatc      360

aaaaacatga ttacagggac atctcaggct gactgtgctg tcctgattgt tgctgctggt      420

gttggtgaat ttgaagctgg tatctccaag aatgggcaga cccgagagca tgcccttctg      480

gcttacacac tgggtgtgaa acaactaatt gtcggtgtta acaaaatgga ttccactgag      540

ccaccctaca gccagaagag atatgaggaa attgttaagg aagtcagcac ttacattaag      600

aaaattggct acaaccccga cacagtagca tttgtgccaa tttctggttg gaatggtgac      660

aacatgctgg agccaagtgc taacatgcct tggttcaagg gatggaaagt cacccgtaag      720

gatggcaatg ccagtggaac cacgctgctt gaggctctgg actgcatcct accaccaact      780

cgtccaactg acaagccctt gcgcctgcct ctccaggatg tctacaaaat tggtggtatt      840

ggtactgttc ctgttggccg agtggagact ggtgttctca aacccggtat ggtggtcacc      900

tttgctccag tcaacgttac aacggaagta aaatctgtcg aaatgcacca tgaagctttg      960

agtgaagctc ttcctgggga caatgtgggc ttcaatgtca agaatgtgtc tgtcaaggat     1020

gttcgtcgtg gcaacgttgc tggtgacagc aaaaatgacc caccaatgga agcagctggc     1080

ttcactgctc aggtgattat cctgaaccat ccaggccaaa taagcgccgg ctatgcccct     1140

gtattggatt gccacacggc tcacattgca tgcaagtttg ctgagctgaa ggaaaagatt     1200

gatcgccgtt ctggtaaaaa gctggaagat ggccctaaat tcttgaagtc tggtgatgct     1260

gccattgttg atatggttcc tggcaagccc atgtgtgttg agagcttctc agactatcca     1320

cctttgggtc gctttgctgt tcgtgatatg agacagacag ttgcggtggg tgtcatcaaa     1380

gcagtggaca agaaggctgc tggagctggc aaggtcacca agtctgccca gaaagctcag     1440

aaggctaaat gaatattatc cctaatacct gccaccccac tcttaatcag tggtggaaga     1500

acggtctcag aactgtttgt ttcaattggc catttaagtt tagtagtaaa agactggtta     1560

atgataacaa tgcatcgtaa aaccttcaga aggaaaggag aatgttttgt ggaccacttt     1620

ggttttcttt tttgcgtgtg gcagttttaa gttattagtt tttaaaatca gtacttttta     1680

atggaaacaa cttgaccaaa aatttgtcac agaattttga gacccattaa aaaagttaaa     1740

tgagaaacct gtgtgttcct ttggtcaaca ccgagacatt taggtgaaag acatctaatt     1800

ctggttttac gaatctggaa acttcttgaa aatgtaattc ttgagttaac acttctgggt     1860

ggagaatagg gttgttttcc ccccacataa ttggaagggg aaggaatatc atttaaagct     1920

atgggagggt tgctttgatt acaacactgg agagaaatgc agcatgttgc tgattgcctg     1980

tcactaaaac aggccaaaaa ctgagtcctt gtgttgcata gaaagcttca tgttgctaaa     2040

ccaatgttaa gtgaatcttt ggaaacaaaa tgtttccaaa ttactgggat gtgcatgttg     2100

aaacgtgggt taaaatgact gggcagtgaa agttgactat ttgccatgac ataagaaata     2160

agtgtagtgg ctagtgtaca ccctatgagt ggaagggtcc attttgaagt cagtggagta     2220

agctttatgc cagtttgatg gtttcacaag ttctattgag tgctattcag aataggaaca     2280

aggttctaat agaaaaagat ggcaatttga agtagctata aaattagact aatctacatt     2340

gcttttctcc tgcagagtct aatacctttt atgctttgat aattagcagt ttgtctactt     2400

ggtcactagg aatgaaacta catggtaata ggcttaacag gtgtaatagc ccacttactc     2460

ctgaatcttt aagcatttgt gcatttgaaa aatgcttttc gcgatcttcc tgctgggatt     2520

acaggcatga gccactgtgc ctgacctccc atatgtaaaa gtgtctaaag gttttttttt     2580

ggttataaaa ggaaaatttt tgcttaagtt tgaaggatag gtaaaattaa aggacatgct     2640

ttctgtttgt gtgatggttt ttaaaaattt tttttaagat ggagttcttg ttgcccaggc     2700

tagaatgcaa tggcaaaatc tcactgcaat ctcctcctcc tgggttcaag caattctcct     2760

acttcagcct cccaagtagc tgggattaca ggcatgtgct aatttggtgt ttttaataga     2820

gatgaggttt ttccatgttg gtcaggctgg tctcaaactc ctgaccttag gtgatcgcct     2880

cggcctccta aagtgctgga attacaggca tgagccacca tgcctggcca ggacatgtgt     2940

tcttaaggac atgctaagca ggagttaaag cagcccaaga gataaggcct cttaaagtga     3000

ctggcaatgt gtattgctca agattcaaag gtacttgaat tggccataga caagtctgta     3060

atgaagtgtt atcgttttcc ctcatctgag tctgaattag ataaaatgcc ttcccatcag     3120

ccagtgctct gaggtatcaa gtctaaattg aactagagat ttttgtcctt agtttctttg     3180

ctatctaatg tttacacaag taaatagtct aagatttgct ggatgacaga aaaaacaggt     3240

aaggccttta atagatggcc aatagatgcc ctgataatga aagttgacac ctgtaagatt     3300

taccagtaga gaattcttga catgcaagga agcaagattt aactgaaaaa ttgttcccac     3360

tggaagcagg aatgagtcag tttacttgca tatactgaga ttgagattaa cttcctgtga     3420

aacccagtgt cttagacaac tgtggcttga gcaccacctg ctggtattca ttacaaactt     3480

gctcactaca ataaatgaat tttaagcttt aaaaaaaaaa aaaaaaaa                  3528


<210>  92
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  93
<211>  1447
<212>  DNA
<213>  Homo sapiens

<400>  93
actttccaca cgctgggagg gccgttacct cagagatacc cgtggccggc atgttggttg       60

aaaaagcttc ccggaaggga gacgaagaga aaggagagga gcagctcgtg atcatccccg      120

gtagcgagta cgcggcgaag taggcggcgg cggagggagc gctgatgaag atggatgtgt      180

cagtgagggc cgcgggctgc tccgacgacc tcagctctgg ggaggccgac gtagacccaa      240

agctcctgga gctcaccgct gacgaggaga agtgccgcag catccgcagg cagtaccggc      300

agctcatgta ctgcgtgcgg cagaaccggg aggacatcgt gagctcggcg aacaactcct      360

taaccgaggc tctggaggaa gccaacgtcc tctttgatgg cgtgagccga accagagaag      420

cagccctcga cgcccggttt cttgttatgg cttctgattt gggtaaagaa aaggcaaagc      480

agttaaactc agatatgaac ttctttaatc agttagcatt ttgtgacttt ctgtttctgt      540

tcgtgggtct gaattggatg gaaggcgatc ctgacaagtt gagtgattgt gatgatagca      600

tagctctttc cttctggaag gcaatagaaa aggaagcaac atcctggatg gtaaaagctg      660

agacattcca ttttgttttt ggttcattca agctagaacg ttctgcacca aagccccgac      720

ttgaacacca gaaaaaagtt cgcaagatgg aagaaaatgg caacatgcct acaaagttgc      780

agaagttgga cctgagtagt tatccagaag cgacagaaaa aaacgtagaa aggattttgg      840

gattgttgca aacctacttt cgaaagtatc ctgatactcc tgtgtcctat tttgagtttg      900

tgattgatcc aaactctttt tctcgtactg tggagaatat attttatgtt tcttttattg      960

taagagatgg ttttgcaaga ataaggcttg atgaagacag gctgccaata ttagagccga     1020

tgaatgttaa ccaaatgggt gagggaaatg attccagttg ccatggcagg aaacagggag     1080

ttatatcttt gactttacag gagtggaaaa acattgtggc agcttttgaa atttctgagg     1140

ctatgattac atactcctca tactaaagat ttcttagtat agcatccttt ttgtgttttt     1200

tttctgaagt tagatggaga gtaaaatgta aactgaagca catattgtat ctcttgtaaa     1260

gtgaaaaagt attttcaaga acatcagaca ttgttttact gtgcagcata tttttcttag     1320

taatttataa ggtcatgatc ttctgttatt aaaacaaatt cactggcata tttatgggaa     1380

cgttttattg aatgcccttt aagactatta ataaaaacaa gttttggata ccaaaaaaaa     1440

aaaaaaa                                                               1447


<210>  94
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Lys Met Asp Val Ser Val Arg Ala Ala Gly Cys Ser Asp Asp Leu 
1               5                   10                  15      


Ser Ser Gly Glu Ala Asp Val Asp Pro Lys Leu Leu Glu Leu Thr Ala 
            20                  25                  30          


Asp Glu Glu Lys Cys Arg Ser Ile Arg Arg Gln Tyr Arg Gln Leu Met 
        35                  40                  45              


Tyr Cys Val Arg Gln Asn Arg Glu Asp Ile Val Ser Ser Ala Asn Asn 
    50                  55                  60                  


Ser Leu Thr Glu Ala Leu Glu Glu Ala Asn Val Leu Phe Asp Gly Val 
65                  70                  75                  80  


Ser Arg Thr Arg Glu Ala Ala Leu Asp Ala Arg Phe Leu Val Met Ala 
                85                  90                  95      


Ser Asp Leu Gly Lys Glu Lys Ala Lys Gln Leu Asn Ser Asp Met Asn 
            100                 105                 110         


Phe Phe Asn Gln Leu Ala Phe Cys Asp Phe Leu Phe Leu Phe Val Gly 
        115                 120                 125             


Leu Asn Trp Met Glu Gly Asp Pro Asp Lys Leu Ser Asp Cys Asp Asp 
    130                 135                 140                 


Ser Ile Ala Leu Ser Phe Trp Lys Ala Ile Glu Lys Glu Ala Thr Ser 
145                 150                 155                 160 


Trp Met Val Lys Ala Glu Thr Phe His Phe Val Phe Gly Ser Phe Lys 
                165                 170                 175     


Leu Glu Arg Ser Ala Pro Lys Pro Arg Leu Glu His Gln Lys Lys Val 
            180                 185                 190         


Arg Lys Met Glu Glu Asn Gly Asn Met Pro Thr Lys Leu Gln Lys Leu 
        195                 200                 205             


Asp Leu Ser Ser Tyr Pro Glu Ala Thr Glu Lys Asn Val Glu Arg Ile 
    210                 215                 220                 


Leu Gly Leu Leu Gln Thr Tyr Phe Arg Lys Tyr Pro Asp Thr Pro Val 
225                 230                 235                 240 


Ser Tyr Phe Glu Phe Val Ile Asp Pro Asn Ser Phe Ser Arg Thr Val 
                245                 250                 255     


Glu Asn Ile Phe Tyr Val Ser Phe Ile Val Arg Asp Gly Phe Ala Arg 
            260                 265                 270         


Ile Arg Leu Asp Glu Asp Arg Leu Pro Ile Leu Glu Pro Met Asn Val 
        275                 280                 285             


Asn Gln Met Gly Glu Gly Asn Asp Ser Ser Cys His Gly Arg Lys Gln 
    290                 295                 300                 


Gly Val Ile Ser Leu Thr Leu Gln Glu Trp Lys Asn Ile Val Ala Ala 
305                 310                 315                 320 


Phe Glu Ile Ser Glu Ala Met Ile Thr Tyr Ser Ser Tyr 
                325                 330             


<210>  95
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  95
tagctaggca ggaagtcggc gcgggcggcg cggacagtat ctgtgggtac ccggagcacg       60

gagatctcgc cggctttacg ttcacctcgg tgtctgcagc accctccgct tcctctccta      120

ggcgacgaga cccagtggct agaagttcac catgtctatt ctcaagatcc atgccaggga      180

gatctttgac tctcgcggga atcccactgt tgaggttgat ctcttcacct caaaaggtct      240

cttcagagct gctgtgccca gtggtgcttc aactggtatc tatgaggccc tagagctccg      300

ggacaatgat aagactcgct atatggggaa gggtgtctca aaggctgttg agcacatcaa      360

taaaactatt gcgcctgccc tggttagcaa gaaactgaac gtcacagaac aagagaagat      420

tgacaaactg atgatcgaga tggatggaac agaaaataaa tctaagtttg gtgcgaacgc      480

cattctgggg gtgtcccttg ccgtctgcaa agctggtgcc gttgagaagg gggtccccct      540

gtaccgccac atcgctgact tggctggcaa ctctgaagtc atcctgccag tcccggcgtt      600

caatgtcatc aatggcggtt ctcatgctgg caacaagctg gccatgcagg agttcatgat      660

cctcccagtc ggtgcagcaa acttcaggga agccatgcgc attggagcag aggtttacca      720

caacctgaag aatgtcatca aggagaaata tgggaaagat gccaccaatg tgggggatga      780

aggcgggttt gctcccaaca tcctggagaa taaagaaggc ctggagctgc tgaagactgc      840

tattgggaaa gctggctaca ctgataaggt ggtcatcggc atggacgtag cggcctccga      900

gttcttcagg tctgggaagt atgacctgga cttcaagtct cccgatgacc ccagcaggta      960

catctcgcct gaccagctgg ctgacctgta caagtccttc atcaaggact acccagtggt     1020

gtctatcgaa gatccctttg accaggatga ctggggagct tggcagaagt tcacagccag     1080

tgcaggaatc caggtagtgg gggatgatct cacagtgacc aacccaaaga ggatcgccaa     1140

ggccgtgaac gagaagtcct gcaactgcct cctgctcaaa gtcaaccaga ttggctccgt     1200

gaccgagtct cttcaggcgt gcaagctggc ccaggccaat ggttggggcg tcatggtgtc     1260

tcatcgttcg ggggagactg aagatacctt catcgctgac ctggttgtgg ggctgtgcac     1320

tgggcagatc aagactggtg ccccttgccg atctgagcgc ttggccaagt acaaccagct     1380

cctcagaatt gaagaggagc tgggcagcaa ggctaagttt gccggcagga acttcagaaa     1440

ccccttggcc aagtaagctg tgggcaggca agcccttcgg tcacctgttg gctacacaga     1500

cccctcccct cgtgtcagct caggcagctc gaggcccccg accaacactt gcaggggtcc     1560

ctgctagtta gcgccccacc gccgtggagt tcgtaccgct tccttagaac ttctacagaa     1620

gccaagctcc ctggagccct gttggcagct ctagctttgc agtcgtgtaa ttggcccaag     1680

tcattgtttt tctcgcctca ctttccacca agtgtctaga gtcatgtgag cctcgtgtca     1740

tctccggggt ggccacaggc tagatccccg gtggttttgt gctcaaaata aaaagcctca     1800

gtgacccatg ag                                                         1812


<210>  96
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  97
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  97
gggcggcgcc caatgggctg cgcggagcgt cacttcccgg cagcgggagg cgagtggcga       60

gtggcgagtg gcgagtgtca ggggggcggc cggcgggggc ggggcggccg gaggaggcgt      120

tggcagcggg ctcggaccca cgcggcgccg cggcccgcct ggcctgcagc gctcccaccc      180

ccggcggcgg cacgatgccc tttgacttca ggaggtttga catctacagg aaggtgccca      240

aggaccttac gcagccaacg tacaccgggg ccattatctc catctgctgc tgcctcttca      300

tcctcttcct cttcctctcg gagctcaccg gatttataac gacagaagtt gtgaacgagc      360

tctatgtcga tgacccagac aaggacagcg gtggcaagat cgacgtcagt ctgaacatca      420

gtttacccaa tctgcactgc gagttggttg ggcttgacat tcaggatgag atgggcaggc      480

acgaagtggg ccacatcgac aactccatga agatcccgct gaacaatggg gcaggctgcc      540

gcttcgaggg gcagttcagc atcaacaagg tccccggcaa cttccacgtg tccacacaca      600

gtgccacagc ccagccacag aacccagaca tgacgcatgt catccacaag ctctcctttg      660

gggacacgct acaggtccag aacatccacg gagctttcaa tgctctcggg ggagcagaca      720

gactcacctc caaccccctg gcctcccacg actacatcct gaagattgtg cccacggttt      780

atgaggacaa gagtggcaag cagcggtact cctaccagta cacggtggcc aacaaggaat      840

acgtcgccta cagccacacg ggccgcatca tccctgcaat ctggttccgc tacgacctca      900

gccccatcac ggtcaagtac acagagagac ggcagccgct gtacagattc atcaccacga      960

tctgtgccat cattggcggg accttcaccg tcgccggcat cctggactca tgcatcttca     1020

cagcctctga ggcctggaag aagatccagc tgggcaagat gcattgacgc cacacccagc     1080

ctaatggccg aggaccctgg gcatcgccag ccttgcctcc agtgccctgt ctcctttggc     1140

cctcaatctg gtcccaaatc tggctgtgtc ccaaagggtg tgtgggaagt ggggggaaag     1200

tagaggatgg ctcgatgttt tgcagctacc tcttttcccc gtgtttcttt ttagacaaat     1260

tacactgcct gaagttgcag ttcccctttc cctggggagc cccaagaaca gagtcaggca     1320

aggggtgggg agtccaggga tcttggggac ccctcctagg agagctgcag tctcttccct     1380

caggggaaca tcccagaatg catatcgatc agctctcagc caggcttcga caatctcgca     1440

gcccccacta ggtggacaca ttaatgattt ggtttctccc ctgggcagcc aacctgcccc     1500

agaggcacca gacctgggct ttcagctttg ggaccaggct gcccaaaggt actcctttat     1560

acacccggca ccttccacga aagatggtac ttcccaagca agcccctatg atttgtcact     1620

atagatggaa ccctgacttc tgccccatcc cttcctgccc aacctagaac ccaggcctca     1680

agtctttacc ccaccccttt cttgttcttc caagaagcag atgcccagtt gctcagcagc     1740

agcggtagag acttgaatct gcccaccagt cacaaggcgg gtcacagatt cctcttcctc     1800

tcttctcctc gttcctctga accctccacc aatgtgcctc agcctgtgtg ctgtgtggca     1860

acagcattct ggttcccact gccaagatct cccaccactc tgctgggatc tgcagtggca     1920

gggagtgggg gttgtgtaaa ggggaagtca tcttttgaga tccagataga catggtttgt     1980

gcacttacgt ccagatggga agcatccttc ctgcaaccct aaaataatca tgcagcctct     2040

cagacggacg ccatcggtcc caaggcctta ggtggaggaa gcaaagcagg ccaggcctgt     2100

cctgtccgtg gacctctacc ttctggactc cctacgggtg cagagcactt gggtttctct     2160

acagccatcg tggcccactt gacactgtgc tcctccatca gctggtcaca tgccaacacg     2220

ttcccagccc ctgaggcagc tccagggtgc cccacctgct cctgaggtgg gtccctaccc     2280

tgctgctcct cttcatcctt tcccttttgt cctgaaaggg aggagcaatg gtccaggcat     2340

taattccacc cagggaattt tagctatgcc ctcatgtccc agggagagag ccacacgcct     2400

gttttccatt tatagcaaga ttgtttgcat acttttgtaa tgaaggggag tgtccagtgg     2460

aaggattttt aaaattatct tatggatagc tcaagtctct gccatttgta atttttggct     2520

ctaagctccg attggagacg cttctccttg tgcatgtgag ttgactgatg ttgtgagtgt     2580

aaatgcattt ggttatttct ggtatcggtg gccacttgga tggatttttt tacattctgt     2640

tccccagtta caggaaggag tccctttggt gtgtgaatat gtgtgcctgt agagggtggg     2700

gcagggtggg gtggggatgg aaatgtgtgg catgcacatg agttgaaatt cttttatgca     2760

tttttttgaa gaaaaaaaaa aaaacaactc tgaggacata ggggatgtca gtttcctatg     2820

gaagagacac ctctgacccg ttattcttat aatcaaaatc tgaagggaaa aaaatgtttt     2880

agttctttcc ccactcgttg ggttcaacta gattaaaagg ctgattttca gaaataaaaa     2940

aaaaaaaaa                                                             2949


<210>  98
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Pro Phe Asp Phe Arg Arg Phe Asp Ile Tyr Arg Lys Val Pro Lys 
1               5                   10                  15      


Asp Leu Thr Gln Pro Thr Tyr Thr Gly Ala Ile Ile Ser Ile Cys Cys 
            20                  25                  30          


Cys Leu Phe Ile Leu Phe Leu Phe Leu Ser Glu Leu Thr Gly Phe Ile 
        35                  40                  45              


Thr Thr Glu Val Val Asn Glu Leu Tyr Val Asp Asp Pro Asp Lys Asp 
    50                  55                  60                  


Ser Gly Gly Lys Ile Asp Val Ser Leu Asn Ile Ser Leu Pro Asn Leu 
65                  70                  75                  80  


His Cys Glu Leu Val Gly Leu Asp Ile Gln Asp Glu Met Gly Arg His 
                85                  90                  95      


Glu Val Gly His Ile Asp Asn Ser Met Lys Ile Pro Leu Asn Asn Gly 
            100                 105                 110         


Ala Gly Cys Arg Phe Glu Gly Gln Phe Ser Ile Asn Lys Val Pro Gly 
        115                 120                 125             


Asn Phe His Val Ser Thr His Ser Ala Thr Ala Gln Pro Gln Asn Pro 
    130                 135                 140                 


Asp Met Thr His Val Ile His Lys Leu Ser Phe Gly Asp Thr Leu Gln 
145                 150                 155                 160 


Val Gln Asn Ile His Gly Ala Phe Asn Ala Leu Gly Gly Ala Asp Arg 
                165                 170                 175     


Leu Thr Ser Asn Pro Leu Ala Ser His Asp Tyr Ile Leu Lys Ile Val 
            180                 185                 190         


Pro Thr Val Tyr Glu Asp Lys Ser Gly Lys Gln Arg Tyr Ser Tyr Gln 
        195                 200                 205             


Tyr Thr Val Ala Asn Lys Glu Tyr Val Ala Tyr Ser His Thr Gly Arg 
    210                 215                 220                 


Ile Ile Pro Ala Ile Trp Phe Arg Tyr Asp Leu Ser Pro Ile Thr Val 
225                 230                 235                 240 


Lys Tyr Thr Glu Arg Arg Gln Pro Leu Tyr Arg Phe Ile Thr Thr Ile 
                245                 250                 255     


Cys Ala Ile Ile Gly Gly Thr Phe Thr Val Ala Gly Ile Leu Asp Ser 
            260                 265                 270         


Cys Ile Phe Thr Ala Ser Glu Ala Trp Lys Lys Ile Gln Leu Gly Lys 
        275                 280                 285             


Met His 
    290 


<210>  99
<211>  9348
<212>  DNA
<213>  Homo sapiens

<400>  99
agttggcagg ctgctgcggg aggcggcggc ggtaggaagc cggagacagc agggtgacag       60

aattggaaaa tatttaactc ttaacaaatg aattccccac ttgaactctg ccgaattcct      120

gtgccacctc ctcctttaga aaactgatct taatacagag ataaaagagg agtagaaggt      180

aaaagaaaat gctgggaact gaccgttgtg ttgtggaaga atggttatca gaattcaagg      240

cattacctga cactcagatc accagttatg cagcaacttt acaccggaaa aaaacacttg      300

taccagccct ctataaagtt attcaagatt caaataatga gctcctggag cctgtctgcc      360

atcagctgtt tgagctctat cgtagctcag aggttcgact taagaggttc acactgcagt      420

tcttgccaga attgatgtgg gtttatttac ggcttacagt tagccgagac agacagagta      480

atggttgcat tgaagcactt ctgttaggaa tttacaattt ggaaatcgct gataaagatg      540

ggaacaataa agttctgtct ttcactatcc cctccttatc caagccttca atataccatg      600

aaccttcaac aattggatcc atggctttga cagaaggggc attgtgtcag catgatctca      660

tcagagttgt ttatagtgat cttcatcctc agagggaaac attcactgca cagaaccggt      720

ttgaagtcct gagttttctc atgctgtgtt ataattctgc tattgtatat atgcctgcct      780

catcttacca atctctttgt cggatgggtt ccagggtttg tgtgagtggc tttccacggc      840

aacatgaaaa acactggaaa gaactctgtg gtcgaatagt attggatcct gaatttatgg      900

tgcaacttct cacaggggtt tattatgcca tgtataatgg acagtgggac cttggccagg      960

aagttcttga tgatatcatt tatagagccc agctagagct tttttctcaa ccactattgg     1020

ttgccaatgc catgaaaaac tcattaccat ttgatgctcc tgattctaca caagaaggcc     1080

agaaagtcct taaagttgaa gtcactccaa cagtgccgag gatttctcgg actgcaatta     1140

caacagcttc aatccgtcgt catagatgga gaagagaagg tgctgagggt gtaaatggag     1200

gagaggagtc tgtaaacctg aatgatgcag atgaaggatt ttcatcaggg gcttccctca     1260

gcagtcagcc aattgggacc aaaccatcct cctcttctca gaggggaagc ttaaggaaag     1320

tagcaactgg gcgttcagcc aaggataaag aaacagcctc tgccatcaaa tccagtgaga     1380

gccctcgaga ttcagtagtt cgcaagcagt atgtacagca accaactgat cttagtgtag     1440

attcagttga gctgacacca atgaagaaac acctgagcct gcctgctggc caggtggtgc     1500

caaaaatcaa tagcttaagt ctaatccgga cagccagtgc ttcctcaagt aaatcatttg     1560

actatgtaaa tggcagtcaa gcaagtacca gcattggggt tggcactgag ggaggtacta     1620

atttagcagc caacaatgct aatcgatact caactgtcag tctgcaggaa gaccggctag     1680

gtcaagctgg cgaaggtaaa gagctcctca gcccaggagc ccccttgacc aagcagtctc     1740

gatccccaag tttcaatatg cagctaatat cccaggtgta gttttgacat cctccctcat     1800

ctttctgctt accttttaaa ctgaacattt cattgtgcaa gaagacactt catcccacat     1860

tgtgaaaata ttggtcactg ttatcagatt tcatttagtt taggtatctt catactgtat     1920

tttgtatcaa aacagcaata aggttttctt tatccctctt tcctacatct tctcttcacc     1980

tatcccttgt aaatgtgttt gtgaagcagt ataaaatggt tgccttttcc atgccttcct     2040

ttctccttgg gtgatgtgca atccatcgta ggctgatcgg tcccatttca acactgtgag     2100

actgagggta cattagagga aatggtgtat atgatcccta tgaaacgatt ctttggcttt     2160

tgtttaaaaa caaaacgggt ttgttctcat aatctataga actatgaaga ttactggatc     2220

atattttttt ctcttaacca ggagtgcctc agagattctg ctatgacttt ggacttctct     2280

gagtctgtgc aatcattttc tggagaagca tggggaaagg tggtagactg ctgcactttt     2340

tcattaaaat gagggtagct ctttctccac ccccccatct cctttatccc gaagacataa     2400

atgttcaatt acggaggcat ttaaatcaag ttgtgaccac ctccattgga gggcaggact     2460

cttgattgtg taattgataa tgcactttct caatggctgt atagtcatta ttaacgtgtc     2520

ttccctcttc cccacaagga catataaggt catttctgtc cttcaagttt ggccaactaa     2580

caaatcagaa tctgaggggc atgttctatt tcccaggaat gattgacact ttggtgctgg     2640

ggttttgtgg gggcgggggg tagtttttgt ttagcttttg tggagattgt gtgtgtgaga     2700

ggagatttga tttttttttc ttcttttcct ttgtgagctg atggctgaag tgtaacagta     2760

catcttcagg taaagagagg gatttctcaa tctactttct gttatgtcag actataagag     2820

aaaccctttc agctgctttc tagatgtacc taaattcagt cagacatttt ggattaagaa     2880

acctaaagtc ctgatacatt acatactcca aggaaatata tcagggacag acaattggct     2940

gaaacactga tacttcaatg tgacacattt ttatagaaca tttctaccag ggggtactga     3000

ccttgatttc tcctacaagg accacactgc ctttgtgttt aatgtaatgc aatttgtgta     3060

ccttctaatc atatatctgc agttcctcat ttttataaaa ctttgatatc atgccagtaa     3120

gctagatgtt gaatgtatgt aagtagcatt tggtaactgc taagaggtta caaaaacatt     3180

attggtaaaa aaaatttcct tagttctgat ctggttggat aagattttat cataactttt     3240

ctgggtctca ggctctgatg tttgaaaaag aagggaatat attgggtttt aaaaaagtgt     3300

attgtgactt aaactgttat aagttatcct tccacagaat acatcagagc tatcagtgct     3360

ttgtacattt agatgttttt acttgattat tgtttaagaa aaatatactg aatttataga     3420

aagcaagtat tctcctaatt agcaaaagtt aaaattttat ctctaccatt aaaattacaa     3480

tagattttga taaataacca gaaaaaacgc cttttttttt ttcacaccta gcaatcctcc     3540

cgtttttatt gtaaggactt tcttttttcc ctaagagact ttctgttaga ctctttatat     3600

atgagatgct tgtttaaata tggtggtctg taacattttt ccagctcatg tgaaaatgga     3660

aaactagaac ctgaactagt atctacaaca ttgccaaagt ccagggtaaa gctaaaagtt     3720

gataagtaga caatttattg ttttgtgtgt gtctgtgtgt gtgtgtgtgt gtgtgtgtgt     3780

gtgtgtatgg tgtgtatatg tatatatcac aaagttgtat tttaaatatt ttaaataccc     3840

tttcttttaa tttaagggat gtcaaataaa tgaaaggagt ttaaaaatag ccaaaataaa     3900

tgagctataa aggcccataa catactaaaa caggcagttt caggtatgta aggaaaggaa     3960

cattatactt acctagaaag tgagatctaa aaaaaaatta aaaataaata aaaaataaaa     4020

aagaaagtga gatcttggct atggctggag gtcagtcact ttatggcata aattatttgg     4080

gaggtaaaaa gactgttttc aattcaaatt gtgcatttat tggcatctaa atctagcatg     4140

attttggtta gagcacaaaa gaaataccac ataataccaa atcacagcaa atgttagaat     4200

taatacaaca aaattttcct ttggctagaa atcttatgtt atacctgaaa aattggtttt     4260

aaaaaatgtt catcttggcc gggcacggtg gctcacgcct gtaatcccaa cactctggga     4320

ggctgaggtg ggtgaatcat gaggtcagga gttcgagacc agcctggcca acatggtgaa     4380

accctgtctc tactaaaaat acaaaaaatt agctgggcgt ggtggcaggc gcctgtaatc     4440

ccagctactc gggaggctga ggcaggagaa tctcttgaac ctgggaggtg gaggttgcag     4500

tgagccaaga atgcactact gtactccagc ctaggcaaca gtgcaagact ccatctctga     4560

aaaaaaaaaa aaaaaaaaaa aaaaaagttc atcttagagg attttattta tctgtatgta     4620

tatacatata tgtttgtatg tatacatacc cacattaaca ttttatgacc ctgtaacatt     4680

tgttttctat tcttttaggt gatgtgaatt gacctcagtg aagaaacatt tcatttagtc     4740

taagccttgc attcagggtc ttacaacaga tttcttgtgc aagaattatt attagttaaa     4800

atggaaggtg ttagtttaac aaactgagag tcaaattttc taagttttta aatatgcatt     4860

ttaacatgca ttatttttgg catttaattt aaaatagttt tgtttcatgt atacaacagc     4920

tgttacagat atatgccagc aatattcata cttttttaac aagcttttgt tatatatttt     4980

ctaatctcca taaaagtcta atcatctatg aaaaagatat ttagggagaa aatacttgtt     5040

ttctgtaata aaacaattag gttggtgcca tgtatgccaa gttggataaa agaatacaaa     5100

gaaacagctg aaggttttgg gagctcgctc tgacattaat tactagaaag caaactaaaa     5160

tgcaaagtga atagttaact cagaagattt gaattttttg aaatagggtc tcactctgtc     5220

ctctaggcta gagtgcagtg gcactatcac ggctcactgc agcctcaacc tccctgggct     5280

caggtgatct tcccacctca gcctctggag tagctggaac tccaggcatg caccaccaca     5340

cctggctaat ttttgtattt ttagtagaga cgaggttttg ccatgttgcc caggctggtc     5400

tcgaactcct gggcttaaga gatccaccca cctggcctcc cagaagtgct aggattacag     5460

acataactac cacacctggc ctgaagattt ttaaatgtga aaatatttta agaagctaag     5520

gggaaaatcg ttattttaaa atcctgatcc ccttaacttt accccttacc attcccctta     5580

cctttccaat tcacttttgt ctatttatta tagaatcaga attgtgctaa gaagaaaccc     5640

tggagataat ctagctagtc tcccactccc tcaccccaac cttcatcctc aagaaacaga     5700

ggctcagagg ttgtggtgtg atcaagatca tatacctaaa gcagagccag aatcaaaccc     5760

agtctcccat gggtttgggg aggcagtggg ttgttaactc catttttgca gtttctttat     5820

agttctggtc tagtagttgg tgaatacaac acattaagaa aagtgttaaa tccagaaaaa     5880

atgtagagta atctagatgg ggaaatgttg gaaatgttaa gtatatctac agatgtaagg     5940

atcaatacat tattctaatt tatgccttac tattttctgc cacataacag ttgtatgctg     6000

ccattttata gttgaataca tttgttggga tttatttaaa tataaaataa accctgtgaa     6060

atggctttga tcagtgtttt ctagttattt taaagtaatt tttgagtcag ccagctttca     6120

gtcaccagtg tggcaagcta attatattgc acaatagagt attgcaaagt aaagattaaa     6180

taaatttgat tccattactt tttaatgtag aaagagactg aatcttatgc ttagagcaaa     6240

tgcaagcaat atttccttat atgattgaaa aaggttctat agtgtgaagc ttatgattcc     6300

ataatggaac agtgaccatg atgtcattta aagtgtgtat ataccatata aaatgtctta     6360

aatgcggtag tctcagctat ataagctcag tatttccagt ctgtattctc agattccatc     6420

tagtagcttt aaattaatta aaattgttta ttagacactg gaatactgag aataacttct     6480

ttcagattgt tttgtttgca ccacttttgt gaatatttta atgaagtgga gtccattttt     6540

gagtacttca gttgttgaca atcagttgtc tcgtttaaat ctctgcatgt tcatttgtaa     6600

ataaaaaatg tagtacctgt ctttaggggt agtcccctat ttattacaaa cactggcaag     6660

gaatatctgt ccatttctga ccttggatta caaagtatgt tttgggtttt tcctttttta     6720

atcagtattt cagttacatc tttgttttca gctttaaaaa gtttaacggg tcatgccaat     6780

gatcagaaaa tctgtaagaa ttttagagca atttttctat gtacagctat gttaaacagt     6840

ctgaacatga gactttttct ttcaagttga agattattgt catcgtttta ccactaagtt     6900

ggttgagaca cttacttgta atactttaat ttttttaaag tgtttttaga aacaagttgt     6960

ttgaaaacca attagaaatt agaatatttg ccagattata agcagatgga atgcagtgta     7020

aaactgttaa caatgctaat aaaattatga gtcatcagat tggtacagtt ttccctgcca     7080

agatggtcat attgataatg taagacaaat tttagtatta cttgcattat gtgtacctaa     7140

taggtatatc atactggtac tgagcatata tagaaaatac tattcataga ggagtcatca     7200

ccacccaacc tccttgcctg tgtaggcata tttcttctga acctgaccac acaagtacaa     7260

cattttggta acttcagtct tttcagtatt tttgtaatct tagccatagt cctatgagaa     7320

atgtacataa gagcaaacaa ttcaggatag aaattagcag aaagctggga atgatgtgaa     7380

ataactggca gcatagtaca gaaatgtaag gtatatgttt tgcttctgga tttttagaaa     7440

ttgtgctaat catgtttaca aattaaggca tattcagatg tctgctatta tgtttaatat     7500

tgatttgata aaaaaatgga attaggtgta gcttagagta taaatgagtc tttttaaaaa     7560

tgtgtatctg gaagtagggc taataaagaa atccttttat tttcaaagaa atgaacttaa     7620

ttggacaact catccccaat tacagaattg atatcaatat ggtttgctgt atttgagtat     7680

aaacagctca gtgttaatta tatcaaagga agttctttac atcttcattg attacaaaat     7740

ttaccaaaga aaatgtatct accaaatata atttttaaag tacttgttaa ggaatgaggc     7800

ctctttaaca tataaagtat cttaaaaata ttctctgacc tggaaaatag gtttacagta     7860

gctacaagat tccattttag gttttcttat gtcaataaat gtcaatattt tacacttcca     7920

gcaaaagtac ccgttaaagc taaatctaaa tattattcct catagcacag tttctggtct     7980

ccttaaatta aggatcctac tcatcaggat tgaataaaaa gggggaaatt cctaaaattg     8040

gtatattgta taatattgtg ggttaagtaa aatttagggg ggcattatgg aaatgtacct     8100

attttaaagg gcagtggcaa ttactataat attggttaaa ctggtaaagt ttgttaaata     8160

atttatgtcc atgatcattc tgagtgtttt ttttctttgc agaaaaacag gattgggtta     8220

agaaaagcta aaatactcat ttttttaaaa tgtatagccc aataagaact aaatgattta     8280

tttcaaaagt taaataattt tttttggaaa tcatggaatg tatttgcata ttgatgttcc     8340

aaacaggttt tatgtattgt tttttatagc agggagtagt tgaaaagtaa tgagtatatt     8400

gattagctgt cttggaaaga gaggattggc tttctaacaa tcactgatac aggtttgggt     8460

ttgggggggt ttgtttgttt gtttttaagt tttatcatcc atactgaatt gagagatatg     8520

ctccatgttt aaaaatattt gtaataagtt catctacttg acactgaatc ttttttattc     8580

ttactctaaa attattctgg ctttacattc agtttaagtg gttaagtgaa acagttttta     8640

gggtgcaaaa attattttcc cactgttttt ctcatgataa tttgagtctc ctgagctata     8700

atttctgaag gatttttact actttggcat tatgtaatct gatctctgtc acaatgatat     8760

taaataagaa ctatctcact ttcatatgtt tgcttcataa aaggatatgg aatgtacaca     8820

tcagctcttt tttttttttt aaactagcat caacctataa cttggtataa acttcccaag     8880

tatttagaga atagtgctgg tgaaaattta aataggatag gcatatagaa attatgactt     8940

gtattgagtg atgtcctttc aacctaggac tagtgacaac cttcattttt tcagagctga     9000

agaaaaaacc gtgaatttaa gatcatattt attggtgcat gtaagccatt atcctgtctt     9060

aatgaaccga ttaatgctgt tgattgttga aatgtgaaat gtagtcactg ttgaccttgt     9120

aaatatctgc cagagatgaa aaaatatttt aagttattgt aaataaagat gtataaaatt     9180

cagtatcagt ctgcaatgca gaaacatatc ttagatgtta aaatactgtg tttgagagat     9240

gtgtaattta cccttagatg tatctagtta cattaagagt gtaaattttt ttgtacagta     9300

taaaaataca gctctatttg gcttttaact ggaaaaaaaa aaaaaaaa                  9348


<210>  100
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Leu Gly Thr Asp Arg Cys Val Val Glu Glu Trp Leu Ser Glu Phe 
1               5                   10                  15      


Lys Ala Leu Pro Asp Thr Gln Ile Thr Ser Tyr Ala Ala Thr Leu His 
            20                  25                  30          


Arg Lys Lys Thr Leu Val Pro Ala Leu Tyr Lys Val Ile Gln Asp Ser 
        35                  40                  45              


Asn Asn Glu Leu Leu Glu Pro Val Cys His Gln Leu Phe Glu Leu Tyr 
    50                  55                  60                  


Arg Ser Ser Glu Val Arg Leu Lys Arg Phe Thr Leu Gln Phe Leu Pro 
65                  70                  75                  80  


Glu Leu Met Trp Val Tyr Leu Arg Leu Thr Val Ser Arg Asp Arg Gln 
                85                  90                  95      


Ser Asn Gly Cys Ile Glu Ala Leu Leu Leu Gly Ile Tyr Asn Leu Glu 
            100                 105                 110         


Ile Ala Asp Lys Asp Gly Asn Asn Lys Val Leu Ser Phe Thr Ile Pro 
        115                 120                 125             


Ser Leu Ser Lys Pro Ser Ile Tyr His Glu Pro Ser Thr Ile Gly Ser 
    130                 135                 140                 


Met Ala Leu Thr Glu Gly Ala Leu Cys Gln His Asp Leu Ile Arg Val 
145                 150                 155                 160 


Val Tyr Ser Asp Leu His Pro Gln Arg Glu Thr Phe Thr Ala Gln Asn 
                165                 170                 175     


Arg Phe Glu Val Leu Ser Phe Leu Met Leu Cys Tyr Asn Ser Ala Ile 
            180                 185                 190         


Val Tyr Met Pro Ala Ser Ser Tyr Gln Ser Leu Cys Arg Met Gly Ser 
        195                 200                 205             


Arg Val Cys Val Ser Gly Phe Pro Arg Gln His Glu Lys His Trp Lys 
    210                 215                 220                 


Glu Leu Cys Gly Arg Ile Val Leu Asp Pro Glu Phe Met Val Gln Leu 
225                 230                 235                 240 


Leu Thr Gly Val Tyr Tyr Ala Met Tyr Asn Gly Gln Trp Asp Leu Gly 
                245                 250                 255     


Gln Glu Val Leu Asp Asp Ile Ile Tyr Arg Ala Gln Leu Glu Leu Phe 
            260                 265                 270         


Ser Gln Pro Leu Leu Val Ala Asn Ala Met Lys Asn Ser Leu Pro Phe 
        275                 280                 285             


Asp Ala Pro Asp Ser Thr Gln Glu Gly Gln Lys Val Leu Lys Val Glu 
    290                 295                 300                 


Val Thr Pro Thr Val Pro Arg Ile Ser Arg Thr Ala Ile Thr Thr Ala 
305                 310                 315                 320 


Ser Ile Arg Arg His Arg Trp Arg Arg Glu Gly Ala Glu Gly Val Asn 
                325                 330                 335     


Gly Gly Glu Glu Ser Val Asn Leu Asn Asp Ala Asp Glu Gly Phe Ser 
            340                 345                 350         


Ser Gly Ala Ser Leu Ser Ser Gln Pro Ile Gly Thr Lys Pro Ser Ser 
        355                 360                 365             


Ser Ser Gln Arg Gly Ser Leu Arg Lys Val Ala Thr Gly Arg Ser Ala 
    370                 375                 380                 


Lys Asp Lys Glu Thr Ala Ser Ala Ile Lys Ser Ser Glu Ser Pro Arg 
385                 390                 395                 400 


Asp Ser Val Val Arg Lys Gln Tyr Val Gln Gln Pro Thr Asp Leu Ser 
                405                 410                 415     


Val Asp Ser Val Glu Leu Thr Pro Met Lys Lys His Leu Ser Leu Pro 
            420                 425                 430         


Ala Gly Gln Val Val Pro Lys Ile Asn Ser Leu Ser Leu Ile Arg Thr 
        435                 440                 445             


Ala Ser Ala Ser Ser Ser Lys Ser Phe Asp Tyr Val Asn Gly Ser Gln 
    450                 455                 460                 


Ala Ser Thr Ser Ile Gly Val Gly Thr Glu Gly Gly Thr Asn Leu Ala 
465                 470                 475                 480 


Ala Asn Asn Ala Asn Arg Tyr Ser Thr Val Ser Leu Gln Glu Asp Arg 
                485                 490                 495     


Leu Gly Gln Ala Gly Glu Gly Lys Glu Leu Leu Ser Pro Gly Ala Pro 
            500                 505                 510         


Leu Thr Lys Gln Ser Arg Ser Pro Ser Phe Asn Met Gln Leu Ile Ser 
        515                 520                 525             


Gln Val 
    530 


<210>  101
<211>  3417
<212>  DNA
<213>  Homo sapiens

<400>  101
acgggcggcc ggatttgccc ggaggccgca cccgcctccg gcggggctct cagtgaaaaa       60

tgtactctga cctgaatcct gaattttcct tgatggtcaa aagattaaga aatcatgagt      120

ggaggatctc aagtccacat tttttggggt gctccaattg ctccactgaa aatcacagta      180

tcagaagaca cagcttcttt aatgtctgtt gctgacccct ggaaaaaaat tcagctttta      240

tacagtcaac attctttata tctgaaggat gaaaaacagc acaaaaatct tgaaaactat      300

aaagtcccag aatctattgg ttctccagat cttagtggtc atttcttagc aaactgtatg      360

aatagacatg ttcatgtgaa agatgacttt gtacgttctg tttctgaaac acagaatata      420

gaatcccaga agattcactc ctctagactg agtgatataa ctagctctaa tatgcaaata      480

tgtggattta aaagcacagt tccgcatttc accgaagaag aaaagtatca aaagcttctc      540

agtgaaaata aaattagaga tgaacagcct aaacatcagc cagatatatg tggtaagaac      600

tttaacacaa atttgtttca gttgggccat aaatgtgcag ctgtgttgga tttggtttgt      660

agtactgaaa aaattaatat agggcctgaa gtggtacaaa gagagtgtgt gccaacagaa      720

tatcatgaaa tacaaaacca gtgtttggga ttattttcct cgaacgcagt agataagtca      780

aggtctgaag cagcagttag gaaggtctca gaccttaaaa tatcaactga tacagaattt      840

ctcagtataa ttacctccag ccaggttgct tttttagctc aaaagaaaga taaaaggcgg      900

agtcctgtaa ataaagggaa tgtaaacatg gagactgaac caaaggcaag ttacggggag      960

ataagaatac ctgaagagaa ttcgattcag cttgatggtt ttacagaagc atatgaaagt     1020

ggacaaaacc aagcatattc ccttgaactt tttagtcctg tttgtcctaa aacagaaaat     1080

agccgcattc acataaactc tgataaaggt cttgaagaac atacaggatc tcaagaactt     1140

ttcagttctg aagatgaact gccaccaaat gagatacgta ttgagttgtg tagctcagga     1200

atactgtgtt cccaactaaa taccttccac aaaagtgcta ttaaaagaag ctgtacctct     1260

gaagataaag tgggccagtc tgaagctcta tctagagtcc ttcaagtagc taagaaaatg     1320

aagttgattt ctaatggagg agattctgct gtagaaatgg atcggagaaa tgtgtctgaa     1380

tttaagagta ttaaaaaaac atcattaata aaaaactgtg attctaaaag ccagaagtat     1440

aattgtttag tcatggtgct atctccatgc catgtgaagg aaataaacat aaaattcgga     1500

ccaaattctg gctctaaagt gcctttagca acagttacag taattgatca atcagaaact     1560

aagaagaagg tttttctgtg gaggactgca gcattttggg catttacagt gtttcttgga     1620

gatataattt tactcacaga tgttgttatt catgaggacc aatggattgg cgagacagta     1680

ctacaatcaa catttagcag tcagttatta aatcttggga gttattcatc tattcagcct     1740

gaagaatatt ccagtgtagt tagtgaagtt gtacttcaag acttactggc atatgtgtcc     1800

tcaaaacatt cctacctcag agatcttcct ccgaggcagc ctcagagggt gaacagtata     1860

gactttgtag aattggagca ccttcaacct gatgtattag tccacgcagt actaagagtt     1920

gttgatttca ctatactgac agaggcagta tacagttata gaggacagaa gcagaaaaaa     1980

gttatgttaa cagtggaaca ggcccaagat caacattatg cgcttgtatt atggggtcct     2040

ggagcagcct ggtaccctca acttcaaagg aaaaaaggag tggttctgat taaagcccag     2100

atttcagagc tggcatttcc tattacagca tctcagaaga tagcgctaaa tgctcacagt     2160

tctctgaaga gtattttttc ttctcttccc aacatcgtat atactggttg tgcaaaatgt     2220

ggattggaac tagaaacaga tgagaacagg atctacaaac aatgttttag ctgcttgcca     2280

tttactatga agaaaatata ttataggcca gcgttaatga ctgccattga tggaagacat     2340

gatgtttgta tccgtgtaga atcaaagctg atagagaaga ttcttctcaa catttctgca     2400

gactgcctca acagagtgat agttccttcc tcagagatca cctatgggat ggtcgtggca     2460

gacctgttcc actccttgtt ggcagtcagc gcagaacctt gtgtattaaa gattcagagc     2520

ctttttgtgt tagatgaaaa cagctatcca ttacaacaag atttctccct cctggatttt     2580

tatcctgaca ttgtaaagca tggagccaat gcccgtctct gaggccagag gaagaaattg     2640

caggcatttc aaggaagaag tactgaaatg atttgtcttt tgaaataaat gaatgacagg     2700

gcttttgctt tggatttttt atgaaatata ttttacaaag agaattgcac tagatatata     2760

aattaaaact tttttctaag aaaatcctgt gaggtttaaa aagattgttt ttgtcttttg     2820

gtttcttact ttctcctgga gaaatgatct accagtcaag gcaatatgta gcagatccct     2880

gggaattaaa ggtttgccca tttgttcact gtatttagtc cctgctacat tccaggcatt     2940

gtactaagta tggggaacca cagagaagac attccctcag aaactgctgc agtgctttcg     3000

cttatcccta cctaaaaaac cgtcaatgtg aaatcatttc cttgattata actataatga     3060

taatggatta gtttatataa acctatgttt agacaagttc aagacaagcg tgtctttcta     3120

taaaaagtat tgaaaatgaa ggaaatgaga tcatgtttca atttattaaa gcagggaaga     3180

gcgttctgtg cttagttcgt gtctaggatt tgagtgcctt actgaatgca tttaccagca     3240

aacatgtagc aatctgttct ctcattgtga ttgtggaaga agctcatgta aaatgatagt     3300

cattaatgag gaagtatggc gtggtactta ttctgtaagt tcagagtatg ctgagtgtta     3360

atagattatc atattgcctg aaaataaatt catgatgaca tgaaaaaaaa aaaaaaa        3417


<210>  102
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Gly Gly Ser Gln Val His Ile Phe Trp Gly Ala Pro Ile Ala 
1               5                   10                  15      


Pro Leu Lys Ile Thr Val Ser Glu Asp Thr Ala Ser Leu Met Ser Val 
            20                  25                  30          


Ala Asp Pro Trp Lys Lys Ile Gln Leu Leu Tyr Ser Gln His Ser Leu 
        35                  40                  45              


Tyr Leu Lys Asp Glu Lys Gln His Lys Asn Leu Glu Asn Tyr Lys Val 
    50                  55                  60                  


Pro Glu Ser Ile Gly Ser Pro Asp Leu Ser Gly His Phe Leu Ala Asn 
65                  70                  75                  80  


Cys Met Asn Arg His Val His Val Lys Asp Asp Phe Val Arg Ser Val 
                85                  90                  95      


Ser Glu Thr Gln Asn Ile Glu Ser Gln Lys Ile His Ser Ser Arg Leu 
            100                 105                 110         


Ser Asp Ile Thr Ser Ser Asn Met Gln Ile Cys Gly Phe Lys Ser Thr 
        115                 120                 125             


Val Pro His Phe Thr Glu Glu Glu Lys Tyr Gln Lys Leu Leu Ser Glu 
    130                 135                 140                 


Asn Lys Ile Arg Asp Glu Gln Pro Lys His Gln Pro Asp Ile Cys Gly 
145                 150                 155                 160 


Lys Asn Phe Asn Thr Asn Leu Phe Gln Leu Gly His Lys Cys Ala Ala 
                165                 170                 175     


Val Leu Asp Leu Val Cys Ser Thr Glu Lys Ile Asn Ile Gly Pro Glu 
            180                 185                 190         


Val Val Gln Arg Glu Cys Val Pro Thr Glu Tyr His Glu Ile Gln Asn 
        195                 200                 205             


Gln Cys Leu Gly Leu Phe Ser Ser Asn Ala Val Asp Lys Ser Arg Ser 
    210                 215                 220                 


Glu Ala Ala Val Arg Lys Val Ser Asp Leu Lys Ile Ser Thr Asp Thr 
225                 230                 235                 240 


Glu Phe Leu Ser Ile Ile Thr Ser Ser Gln Val Ala Phe Leu Ala Gln 
                245                 250                 255     


Lys Lys Asp Lys Arg Arg Ser Pro Val Asn Lys Gly Asn Val Asn Met 
            260                 265                 270         


Glu Thr Glu Pro Lys Ala Ser Tyr Gly Glu Ile Arg Ile Pro Glu Glu 
        275                 280                 285             


Asn Ser Ile Gln Leu Asp Gly Phe Thr Glu Ala Tyr Glu Ser Gly Gln 
    290                 295                 300                 


Asn Gln Ala Tyr Ser Leu Glu Leu Phe Ser Pro Val Cys Pro Lys Thr 
305                 310                 315                 320 


Glu Asn Ser Arg Ile His Ile Asn Ser Asp Lys Gly Leu Glu Glu His 
                325                 330                 335     


Thr Gly Ser Gln Glu Leu Phe Ser Ser Glu Asp Glu Leu Pro Pro Asn 
            340                 345                 350         


Glu Ile Arg Ile Glu Leu Cys Ser Ser Gly Ile Leu Cys Ser Gln Leu 
        355                 360                 365             


Asn Thr Phe His Lys Ser Ala Ile Lys Arg Ser Cys Thr Ser Glu Asp 
    370                 375                 380                 


Lys Val Gly Gln Ser Glu Ala Leu Ser Arg Val Leu Gln Val Ala Lys 
385                 390                 395                 400 


Lys Met Lys Leu Ile Ser Asn Gly Gly Asp Ser Ala Val Glu Met Asp 
                405                 410                 415     


Arg Arg Asn Val Ser Glu Phe Lys Ser Ile Lys Lys Thr Ser Leu Ile 
            420                 425                 430         


Lys Asn Cys Asp Ser Lys Ser Gln Lys Tyr Asn Cys Leu Val Met Val 
        435                 440                 445             


Leu Ser Pro Cys His Val Lys Glu Ile Asn Ile Lys Phe Gly Pro Asn 
    450                 455                 460                 


Ser Gly Ser Lys Val Pro Leu Ala Thr Val Thr Val Ile Asp Gln Ser 
465                 470                 475                 480 


Glu Thr Lys Lys Lys Val Phe Leu Trp Arg Thr Ala Ala Phe Trp Ala 
                485                 490                 495     


Phe Thr Val Phe Leu Gly Asp Ile Ile Leu Leu Thr Asp Val Val Ile 
            500                 505                 510         


His Glu Asp Gln Trp Ile Gly Glu Thr Val Leu Gln Ser Thr Phe Ser 
        515                 520                 525             


Ser Gln Leu Leu Asn Leu Gly Ser Tyr Ser Ser Ile Gln Pro Glu Glu 
    530                 535                 540                 


Tyr Ser Ser Val Val Ser Glu Val Val Leu Gln Asp Leu Leu Ala Tyr 
545                 550                 555                 560 


Val Ser Ser Lys His Ser Tyr Leu Arg Asp Leu Pro Pro Arg Gln Pro 
                565                 570                 575     


Gln Arg Val Asn Ser Ile Asp Phe Val Glu Leu Glu His Leu Gln Pro 
            580                 585                 590         


Asp Val Leu Val His Ala Val Leu Arg Val Val Asp Phe Thr Ile Leu 
        595                 600                 605             


Thr Glu Ala Val Tyr Ser Tyr Arg Gly Gln Lys Gln Lys Lys Val Met 
    610                 615                 620                 


Leu Thr Val Glu Gln Ala Gln Asp Gln His Tyr Ala Leu Val Leu Trp 
625                 630                 635                 640 


Gly Pro Gly Ala Ala Trp Tyr Pro Gln Leu Gln Arg Lys Lys Gly Val 
                645                 650                 655     


Val Leu Ile Lys Ala Gln Ile Ser Glu Leu Ala Phe Pro Ile Thr Ala 
            660                 665                 670         


Ser Gln Lys Ile Ala Leu Asn Ala His Ser Ser Leu Lys Ser Ile Phe 
        675                 680                 685             


Ser Ser Leu Pro Asn Ile Val Tyr Thr Gly Cys Ala Lys Cys Gly Leu 
    690                 695                 700                 


Glu Leu Glu Thr Asp Glu Asn Arg Ile Tyr Lys Gln Cys Phe Ser Cys 
705                 710                 715                 720 


Leu Pro Phe Thr Met Lys Lys Ile Tyr Tyr Arg Pro Ala Leu Met Thr 
                725                 730                 735     


Ala Ile Asp Gly Arg His Asp Val Cys Ile Arg Val Glu Ser Lys Leu 
            740                 745                 750         


Ile Glu Lys Ile Leu Leu Asn Ile Ser Ala Asp Cys Leu Asn Arg Val 
        755                 760                 765             


Ile Val Pro Ser Ser Glu Ile Thr Tyr Gly Met Val Val Ala Asp Leu 
    770                 775                 780                 


Phe His Ser Leu Leu Ala Val Ser Ala Glu Pro Cys Val Leu Lys Ile 
785                 790                 795                 800 


Gln Ser Leu Phe Val Leu Asp Glu Asn Ser Tyr Pro Leu Gln Gln Asp 
                805                 810                 815     


Phe Ser Leu Leu Asp Phe Tyr Pro Asp Ile Val Lys His Gly Ala Asn 
            820                 825                 830         


Ala Arg Leu 
        835 


<210>  103
<211>  8929
<212>  DNA
<213>  Homo sapiens

<400>  103
atctgctccc gagtccccag ccccgtgctg ataggtgcag cccctggagt cgtggctgtg       60

ggcataggtg ccagggaggg gaggcccggg tcgaaggcat aggcagaatt ggagccctgg      120

gttgccaaag cgtcgcagct aagaagccgg agcccaggct agtaccggcg gggcggggcg      180

gggcggggcc gggagcgagc atctccatcc tcagtttcct ccacttgcgg caacgccaca      240

gctcggtaca gttcggacct ccacgccgca gcgaaagact tctgtcctcc aggcaccttc      300

actaacccgg tgcggagcac ttggcgacgc ctccctgccc atctcatatc tctcggctca      360

tcgctgctct gggcaccagc tgcctcttgg ctggcgctgc tgtcacacgg tggactgttc      420

tggccttact gagctgccgt ttggggacat cagattcagc aagaagaatt gtatagaaat      480

gtaaaaaaca tttatgtgtg cttcacatgt ggcatgaaaa aaatgaggac ctctggtcaa      540

aattgcctga gttcagaatt tcatgctgga aggaaagtta gacgtaactt ctaatttcta      600

gttccagtaa gcatctcttc ttggaaaatt tccaaaaaag agtcctgctc tgttgcccag      660

gctggagtac attggtgtga tgatcatggt tcactgcagc ctcgacctcc caggctcaag      720

caattctcct acctcagcct cctgagtaac tgggactata ggatttcttt gaagaaaaat      780

gtgcttcttg aatcaactgc agtctctcct ctgcataaga gctcttaagg gtactagcag      840

gatagaagca aatgaaactg aaagctcatc tgcagctcag aaaagcaaag acatggaatt      900

ttaaagagtg aaggtagcat ggtgtcggcc atgggtgaac aagacacagc cagacaatgt      960

ggaccaattt cttcaaacta cggcttttct gctgtctgct tgcagtgttg atggtggtgg     1020

tgctggtcat caatgttact caggtagagt acttggacca tgagactgtt tcagccactt     1080

tcatcgacag cagtggacag tttgtttcct cccaggtgac aggaattagc cgaaatccct     1140

actgtggcta tgatcagcag accctgtcca gccaggagcg catggaggag gactccttgc     1200

tggctgcctt gcaccggcag gttcctgatg tgggcccagt cccctttgtg aagagcactg     1260

acccttcttc cagctacttt gtcatcttga actctgctgc cttctttaag gtgggaagcc     1320

agcttgaggt gctggttcat gtgcaggatt ttcaaagaaa gcccaagaag tatggtggag     1380

actacctgca ggccagaatt cactccctca agctgcaggc tggggctgtg ggcagggtgg     1440

tggattacca gaatgggttt tacaaggttt tctttacttt gctatggcca ggcaaagtta     1500

aagtatccgt atctctggtc caccccagtg aagggatcag agttcttcag cgcttacagg     1560

aagataaacc agacagggtc tatttcaaga gtctcttccg ttcaggaaga atttctgaaa     1620

ctactgagtg caacgtgtgt cttcctggga atctgcccct gtgtaacttt acagacctct     1680

acactgggga gccctggttc tgcttcaaac caaagaagct cccttgcagc agcagaatta     1740

cccatttcaa aggtggatac ctgaaaggtc tcctaaccgc tgcagagagt gctttcttcc     1800

agagtggtgt caatatcaaa atgccagtca actccagtgg acctgattgg gtaactgtga     1860

ttcccaggag aataaaagaa actaacagtc tagaactatc tcaaggctca ggaacttttc     1920

cttctgggta ttattataaa gaccagtgga ggcccagaaa gtttaagatg cgtcagttta     1980

atgaccctga caacattaca gagtgcttac aaagaaaagt ggtgcattta tttggtgact     2040

caacaatcag gcaatggttt gaatacctta ctacatttgt tccagattta gtggagttta     2100

acttgggtag tcccaagaat gtgggtccct tccttgcagt ggaccagaag cacaacatcc     2160

tgctcaaata ccgctgccat ggtccaccca tccgcttcac gactgtcttt agcaatgagc     2220

tccattatgt ggcgaatgag ctgaatggca ttgtgggagg gaagaacaca gtggttgcca     2280

tagctgtatg gtctcacttc agcaccttcc ctttggaagt gtacatccgg cggctcagga     2340

acatccgtcg agcagtggtt cggctcctcg atcgaagccc aaagaccgtg gtggtcatcc     2400

ggacggccaa cgcccaagag ctgggacctg aggtgagcct tttcaacagc gactggtaca     2460

actttcagct ggacaccatc cttcggagga tgttctcagg ggttggagta tatctcgtcg     2520

atgcctggga gatgaccctg gcccattatc taccgcacaa gctgcatcca gatgaagtta     2580

ttgtgaagaa ccagctggac atgttcttgt cctttgtgtg ccccttggaa acctagcctg     2640

tcttggaagg gactggagga atcatattca atgaccttct caattgacct gagttacaga     2700

aagtggcccc agtgagagat gactgccctt aataagtata aaatttcaaa aagatctgga     2760

cttaatatga tgacttataa ggagcttaga aaatgcaggt tacatttata tctacctata     2820

ggattttatc caatgttgac ttagccatgg tagaactctt aactgcatct acacactata     2880

ttgctcttgt aaccaaagat gctaatgagt gtatttgaat tagcttctcc taggaggggt     2940

gactactttg ctaaagagta tgaaaaatgt tttgatggaa gggacaagtt tggttggtag     3000

tagagtgttt gtagcttatc tggtaaagga aattgagtgc atctgcatgc atagcacaag     3060

taatccatct tctggcggtt aactagagaa agcttatagt cagaggctct tgtgaatgca     3120

ctgaagactg ctgtgtctca ggagtttctc ttgatgatct accttttctg aattacttga     3180

aaaggccaat gtgcttggtt cgagtttttt agtgaatatt tacaatttcc tgcttttatc     3240

tagaaaagaa gcaaaaggga aatatgaaag cagtatatat aaaatctgtg ctttggaatt     3300

gatatttgca tttggtgatt gttttttatt tgattcagct aaattttatg tgttgaatac     3360

ttactctaga ataactactt ttggaactgg aagggggaaa tctgtaaatg gaaatttatt     3420

tttatgttct gaaatttgag ggtttaggaa ttgacttttg tgtaaagaat gctacggtat     3480

tataaagctg tggaagtttt ttccactagt ttcaggtgtt tttttttttg ttgttgttgt     3540

tgttattttg aactacttac caaaattaga agttaaaatc taattagaaa ttaataagat     3600

actaaaattc atgacagttt tttgtttgtt tgtttgtttg ttttttggta tttcttgatt     3660

tgggcataaa aggcacaccc attctctcat gcttggaaga agctgctatt cctactggct     3720

atctaagaag aatggaatta ttaattttat ttgacttatt aattttaaac gagtttaatt     3780

tgggatcatt tagtaagtac tcttttcttt ttgagctgtg atagattata gtctagttta     3840

agttgctcct aagtagacag atgaagaaac tagggaggct ttagagagga agacagatgc     3900

ttgaagtatg aacaatatat acccttagaa gaatgggtca aataatttgg gtttttaatt     3960

taaaatagga gggccccaga tcttactttc ctgtccttga ggaacacctt caagttttta     4020

aagtatttta gggggaaaga agatttttaa ttgtttctga gcctaatgag gtaataaaat     4080

atattaaaat agtttaattt taatggtcct tacgctttac agtacctaag gatcacttgt     4140

agtatctgac aaaaatgcag aattaaagag tcatggcagg gtgtggtagc tcaagcctgt     4200

aatcccagca ctttgggagg ccaggcagga ggattgcttg aggccaggag tttgagacca     4260

gcctgggcaa catagtaaga cctcatctct acaaaaaata aaaaattatc caggtgtggg     4320

ccgacagtcc cagctactag ggaggctaag gcagggtgat tgattgagcc cagtagtttg     4380

aggctgcagt gagttatgat tgcgccacta cactcccact tgggcaacag acaagagatc     4440

ttatctctaa aaaatttttg ttaaataata aaagaattaa ggccagggat gttggctcac     4500

atctgtaatc ccagcaggga ttatagtctc gggaggctga ggtgggcgga ttgcttgagc     4560

ccggaaggtc aagaccagcc tgggtgccat ggtgaaaccc catctctaca aaaaaataca     4620

aaaactagct gggtgtggtg gcaccacctg tagtccccgc tacttaggag gctgaggtgg     4680

gaggattgct tgagcccagg aggcagaagg ttgcagaggt tgcagtgagc cttgattgtg     4740

ccactgtact ccagtctggg caacagggca agaccctgtc tctaaaaaaa aaaaaaaaaa     4800

aaaaagaggg accatgatgc ctctgggatt tatgaaacca acctttgtgg cgagtgctca     4860

gtgattctga tgcaatggtg gtattccaca ctgtgagaaa cactaagaga agaggtaaga     4920

tagaatgagg gaataaacat ggcttgttta ttattttggg ggatttacca ataactggtt     4980

taattctgtt catgatccaa tagtattggt gatattagct ccattttata gatgaggaac     5040

tcatgtttag atctgaaata aggtatgtga gagtccatat ctcttttcag ctaaacttgt     5100

gagactttcg taaagaagcg tttgtattta tttatttgtt tttgagacag ggtcttgctc     5160

ttttgcccag gctggagtgc agtggcatga tatggctcac tgcagccttg acttcctggg     5220

ctcaagggat ccttctgcct cagcctcctg agtagctggg actacaggta tgtaccacca     5280

tgcccagcta atttttgtat ctttttgtag agactacatt ttgccatgtt gtccaggctg     5340

gtcttaaact cctgagctca agcatctgcc cacctcagct tcccaaagtg ctgggattac     5400

aggtgtgagc cactgtgccc agctgagagt ttttcttgtc gtgaaagaac ttgacatttc     5460

ctcaaggatt tataaaggag gctgaggagt aattttccca ggagaatttt aaaaagaaag     5520

cgggcattgc tcctccagtg gtttggaatg atgccacttg attgtgcaaa tgatttctta     5580

tgatcttgtc tggttttctg ttattttttg atttggtgac atagctctca aagatttggt     5640

gacacagctt cttgagtcac tttcatctct cttaaaaaaa tttttttttt aacaactttt     5700

aagttcaggg gtacatgtgc cagtttgttt cataggtaaa cttacgtcat gggggtttgt     5760

tgtatagatg atttcatcac ccaggtgtta agcctagtac ccattagtaa tttttcctga     5820

tcctctccct cctcctaccc tccaccctcc aatagacccc agtgtgtgtt gttgcccttt     5880

atgtgtccat gtgttctcat catttagctc tcacttatca gtgagaacaa ctttcatccc     5940

acatctaatt tgtctttctt cactctggtg tggaaatttt gatagagatt ccaatatcac     6000

ttaaacgttt cccagaatat ttagatagaa taatttagtt tcttctgaaa agtttatttt     6060

aggctagtgc cacatggttg tgaatattag catggtagcc aaataatagt ttgtttaaat     6120

gtatatttcc caatataaat ataaggggca tcataatttt taaaaactat aaaatctaga     6180

agaaaaatct atggataaaa tccataattc tatcatctga atgcaatgaa cattagcatt     6240

taggtatatt ttcttgcagg ttttttaacc atatacttat agagaatatg taatttgggt     6300

ctgtgttttt tacatataaa tatttttcta tgttaaatag tcttcataag ttaattataa     6360

agatctgctt aatagttctg ctactgcagt tttcattatt agataagttg gtcattatag     6420

ttggacattt aggtttacaa tattaaagca gtggtttata tcaatttcag tggtttaaaa     6480

tatgaatttc tattttggaa tgaaagtatt aatttaatgt agtgaatctc atattccaga     6540

actgagatga ttgatttgat gctatttgtg acagacagaa cccataataa agcctttcta     6600

tgcaagttac attttataga attatcctac taaaagtaac ctttcttcag cgaatgcaaa     6660

acagaccttt ggtgttccag tatgattcat tttgccattc tgaacaacta tcattttaat     6720

taagaccatt taactgacac ttcctggatt cagttattaa gtttcagatt gaaacttgat     6780

ccagtttaat aactgaatcc agtttcacat ttatcaatct gaaaacttag tttgcagatt     6840

ggtaaatcag ggtacttgac aagaataaat atggtacgcc tttatatatt catgtgttac     6900

atgccagaaa tgagtctgtt tctggaccct gttcaaggaa atagtgatga ctgagagagg     6960

tacagggaaa taaacaccca agggaaacaa cagaaataag cctccccaac tttctaaaaa     7020

actgctcagc attatctctg tggattctgg gtaaattcag ctttttaaca tcagctagtc     7080

actaatgcca gaaattccac ttcaagtgta tttattttct tgtgttaagc attattctac     7140

ctggtttatg tctacaatgt agtattagtg tacttaggat tcttgacacc tcagtgtgca     7200

ataaataaaa ttttgaagtt gttgtttttc atttgaaggt gagaccacag cccctgagtg     7260

ctaaggggac ctgggaatcc taggggaatg gaggtggtgg acgataagag gatggttgag     7320

ggcaggagtt taaaggacac agaagctagg agagcagaaa atgtactcca ccaccttctg     7380

tctaacttgt ctcttaaaag tgcttttaca ttttaacttt ttaaaaaaat gtgggccggg     7440

catagtggct catgcctgta atcccagcac tttgggaggc cgaggtgggc ggatcacctg     7500

aggtcaagag ttcaagacca gcctgaccaa tatgatgaaa ccccatctct actaaaaata     7560

caaaaatagc caggtgtggt ggcacatgcc tgtcatccca gctactcagg aggctgaggt     7620

gggagaatcg cttgaacccg ggaggtggag gttgcagtga gccgagatca tgccattgca     7680

ctctagcctg ggcaacgaga gtgaaactct gtctcaataa ataaataaat aaataaaaaa     7740

taaaaaagtg tgaacttaaa tatatttata tgtgtgtaca tatattttct tttttaatat     7800

tctggttaaa tgagaggcca tcgggcctct ttttaagagt ctaatgatgt gtatatctaa     7860

tgcccattcc agctggattg taacactgct tggggaagat aacttaaaaa aaagtagtac     7920

cgagattaca gcagctagtg tcctaaatgg aaaagaagtg aaactaaatg tcataggaga     7980

aatcctttca gttttgtgca gtggttcatt tgctgttaaa tctaccccat taccattccc     8040

cttactcctt gaaaataaag tgatcttcat gttacaggac cattgcttta tttatgtcac     8100

agatttcttg tcctttaatt agtcagtgaa ggcacatgat tgcgatacta ctttttgatt     8160

gccgtattgt aaaagctata tggtaaaagg taactccctc cacccgccca ctgcaccctc     8220

acgtttaggg gccacacaga aaaagcgaaa taagatgagg tgaatctaat gagaaggcaa     8280

ctctaatgcc catcaggaga ttcactagga cattttaaaa ggacgtcttt aaggaaaaag     8340

ttttgtttgt agatgttgcc tctgattcct ccctgcggct ccagtccagg tcttggagcc     8400

ggccctcgag gggaatgtcc gggactcggg tcggtacctt tttggtctgg gaatttccag     8460

tgtgcagaaa aaaaatccac aaatctaggc ctcgctgccc cctccctgcc tcctctggcc     8520

ctcctcagtg cccacgcaac ccggttcgaa agagaggatg accgtattct gcattttaga     8580

aaacaggctc ttagcttccc ccgcccccgt cctcactaga gtggagaact gaaagcgaac     8640

gctataaagg gcgccagtga gaggggctgg cctcctcttg ccacgaggtc agacggcgag     8700

ttcttagaga aaaaggctgc ttagctgctg cttatcatgt aacctcaaaa ggaaactgat     8760

cgtctttctc atgctgtcac gtacttgggt tattatcgct gattacagct ggaaacaatt     8820

gatttgctct tacgtatttg tgtgacttga ctcttcaaac acaaaggtat atttttatta     8880

tctgatattt tattaaaata tcttaaatgg taaaaaaaaa aaaaaaaaa                 8929


<210>  104
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  105
<211>  8610
<212>  DNA
<213>  Homo sapiens

<400>  105
accaatcgta gccgggggtc ggaggtgagg agacgtcgcc gggtgaggaa gcggggggct       60

agcggcctgg cgctgcggcg accgaccggg gcgtcaggat ccctggcccc cggagagcga      120

agggcgggcg ggtcccggag caagaagaat tgtatagaaa tgtaaaaaac atttatgtgt      180

gcttcacatg tggcatgaaa aaaatgagga cctctggtca aaattgcctg agttcagaat      240

ttcatgctgg aaggaaagtt agacgtaact tctaatttct agttccagta agcatctctt      300

cttggaaaat ttccaaaaaa gagtcctgct ctgttgccca ggctggagta cattggtgtg      360

atgatcatgg ttcactgcag cctcgacctc ccaggctcaa gcaattctcc tacctcagcc      420

tcctgagtaa ctgggactat aggatttctt tgaagaaaaa tgtgcttctt gaatcaactg      480

cagtctctcc tctgcataag agctcttaag ggtactagca ggatagaagc aaatgaaact      540

gaaagctcat ctgcagctca gaaaagcaaa gacatggaat tttaaagagt gaaggtagca      600

tggtgtcggc catgggtgaa caagacacag ccagacaatg tggaccaatt tcttcaaact      660

acggcttttc tgctgtctgc ttgcagtgtt gatggtggtg gtgctggtca tcaatgttac      720

tcaggtagag tacttggacc atgagactgt ttcagccact ttcatcgaca gcagtggaca      780

gtttgtttcc tcccaggtga caggaattag ccgaaatccc tactgtggct atgatcagca      840

gaccctgtcc agccaggagc gcatggagga ggactccttg ctggctgcct tgcaccggca      900

ggttcctgat gtgggcccag tcccctttgt gaagagcact gacccttctt ccagctactt      960

tgtcatcttg aactctgctg ccttctttaa ggtgggaagc cagcttgagg tgctggttca     1020

tgtgcaggat tttcaaagaa agcccaagaa gtatggtgga gactacctgc aggccagaat     1080

tcactccctc aagctgcagg ctggggctgt gggcagggtg gtggattacc agaatgggtt     1140

ttacaaggtt ttctttactt tgctatggcc aggcaaagtt aaagtatccg tatctctggt     1200

ccaccccagt gaagggatca gagttcttca gcgcttacag gaagataaac cagacagggt     1260

ctatttcaag agtctcttcc gttcaggaag aatttctgaa actactgagt gcaacgtgtg     1320

tcttcctggg aatctgcccc tgtgtaactt tacagacctc tacactgggg agccctggtt     1380

ctgcttcaaa ccaaagaagc tcccttgcag cagcagaatt acccatttca aaggtggata     1440

cctgaaaggt ctcctaaccg ctgcagagag tgctttcttc cagagtggtg tcaatatcaa     1500

aatgccagtc aactccagtg gacctgattg ggtaactgtg attcccagga gaataaaaga     1560

aactaacagt ctagaactat ctcaaggctc aggaactttt ccttctgggt attattataa     1620

agaccagtgg aggcccagaa agtttaagat gcgtcagttt aatgaccctg acaacattac     1680

agagtgctta caaagaaaag tggtgcattt atttggtgac tcaacaatca ggcaatggtt     1740

tgaatacctt actacatttg ttccagattt agtggagttt aacttgggta gtcccaagaa     1800

tgtgggtccc ttccttgcag tggaccagaa gcacaacatc ctgctcaaat accgctgcca     1860

tggtccaccc atccgcttca cgactgtctt tagcaatgag ctccattatg tggcgaatga     1920

gctgaatggc attgtgggag ggaagaacac agtggttgcc atagctgtat ggtctcactt     1980

cagcaccttc cctttggaag tgtacatccg gcggctcagg aacatccgtc gagcagtggt     2040

tcggctcctc gatcgaagcc caaagaccgt ggtggtcatc cggacggcca acgcccaaga     2100

gctgggacct gaggtgagcc ttttcaacag cgactggtac aactttcagc tggacaccat     2160

ccttcggagg atgttctcag gggttggagt atatctcgtc gatgcctggg agatgaccct     2220

ggcccattat ctaccgcaca agctgcatcc agatgaagtt attgtgaaga accagctgga     2280

catgttcttg tcctttgtgt gccccttgga aacctagcct gtcttggaag ggactggagg     2340

aatcatattc aatgaccttc tcaattgacc tgagttacag aaagtggccc cagtgagaga     2400

tgactgccct taataagtat aaaatttcaa aaagatctgg acttaatatg atgacttata     2460

aggagcttag aaaatgcagg ttacatttat atctacctat aggattttat ccaatgttga     2520

cttagccatg gtagaactct taactgcatc tacacactat attgctcttg taaccaaaga     2580

tgctaatgag tgtatttgaa ttagcttctc ctaggagggg tgactacttt gctaaagagt     2640

atgaaaaatg ttttgatgga agggacaagt ttggttggta gtagagtgtt tgtagcttat     2700

ctggtaaagg aaattgagtg catctgcatg catagcacaa gtaatccatc ttctggcggt     2760

taactagaga aagcttatag tcagaggctc ttgtgaatgc actgaagact gctgtgtctc     2820

aggagtttct cttgatgatc taccttttct gaattacttg aaaaggccaa tgtgcttggt     2880

tcgagttttt tagtgaatat ttacaatttc ctgcttttat ctagaaaaga agcaaaaggg     2940

aaatatgaaa gcagtatata taaaatctgt gctttggaat tgatatttgc atttggtgat     3000

tgttttttat ttgattcagc taaattttat gtgttgaata cttactctag aataactact     3060

tttggaactg gaagggggaa atctgtaaat ggaaatttat ttttatgttc tgaaatttga     3120

gggtttagga attgactttt gtgtaaagaa tgctacggta ttataaagct gtggaagttt     3180

tttccactag tttcaggtgt tttttttttt gttgttgttg ttgttatttt gaactactta     3240

ccaaaattag aagttaaaat ctaattagaa attaataaga tactaaaatt catgacagtt     3300

ttttgtttgt ttgtttgttt gttttttggt atttcttgat ttgggcataa aaggcacacc     3360

cattctctca tgcttggaag aagctgctat tcctactggc tatctaagaa gaatggaatt     3420

attaatttta tttgacttat taattttaaa cgagtttaat ttgggatcat ttagtaagta     3480

ctcttttctt tttgagctgt gatagattat agtctagttt aagttgctcc taagtagaca     3540

gatgaagaaa ctagggaggc tttagagagg aagacagatg cttgaagtat gaacaatata     3600

tacccttaga agaatgggtc aaataatttg ggtttttaat ttaaaatagg agggccccag     3660

atcttacttt cctgtccttg aggaacacct tcaagttttt aaagtatttt agggggaaag     3720

aagattttta attgtttctg agcctaatga ggtaataaaa tatattaaaa tagtttaatt     3780

ttaatggtcc ttacgcttta cagtacctaa ggatcacttg tagtatctga caaaaatgca     3840

gaattaaaga gtcatggcag ggtgtggtag ctcaagcctg taatcccagc actttgggag     3900

gccaggcagg aggattgctt gaggccagga gtttgagacc agcctgggca acatagtaag     3960

acctcatctc tacaaaaaat aaaaaattat ccaggtgtgg gccgacagtc ccagctacta     4020

gggaggctaa ggcagggtga ttgattgagc ccagtagttt gaggctgcag tgagttatga     4080

ttgcgccact acactcccac ttgggcaaca gacaagagat cttatctcta aaaaattttt     4140

gttaaataat aaaagaatta aggccaggga tgttggctca catctgtaat cccagcaggg     4200

attatagtct cgggaggctg aggtgggcgg attgcttgag cccggaaggt caagaccagc     4260

ctgggtgcca tggtgaaacc ccatctctac aaaaaaatac aaaaactagc tgggtgtggt     4320

ggcaccacct gtagtccccg ctacttagga ggctgaggtg ggaggattgc ttgagcccag     4380

gaggcagaag gttgcagagg ttgcagtgag ccttgattgt gccactgtac tccagtctgg     4440

gcaacagggc aagaccctgt ctctaaaaaa aaaaaaaaaa aaaaaagagg gaccatgatg     4500

cctctgggat ttatgaaacc aacctttgtg gcgagtgctc agtgattctg atgcaatggt     4560

ggtattccac actgtgagaa acactaagag aagaggtaag atagaatgag ggaataaaca     4620

tggcttgttt attattttgg gggatttacc aataactggt ttaattctgt tcatgatcca     4680

atagtattgg tgatattagc tccattttat agatgaggaa ctcatgttta gatctgaaat     4740

aaggtatgtg agagtccata tctcttttca gctaaacttg tgagactttc gtaaagaagc     4800

gtttgtattt atttatttgt ttttgagaca gggtcttgct cttttgccca ggctggagtg     4860

cagtggcatg atatggctca ctgcagcctt gacttcctgg gctcaaggga tccttctgcc     4920

tcagcctcct gagtagctgg gactacaggt atgtaccacc atgcccagct aatttttgta     4980

tctttttgta gagactacat tttgccatgt tgtccaggct ggtcttaaac tcctgagctc     5040

aagcatctgc ccacctcagc ttcccaaagt gctgggatta caggtgtgag ccactgtgcc     5100

cagctgagag tttttcttgt cgtgaaagaa cttgacattt cctcaaggat ttataaagga     5160

ggctgaggag taattttccc aggagaattt taaaaagaaa gcgggcattg ctcctccagt     5220

ggtttggaat gatgccactt gattgtgcaa atgatttctt atgatcttgt ctggttttct     5280

gttatttttt gatttggtga catagctctc aaagatttgg tgacacagct tcttgagtca     5340

ctttcatctc tcttaaaaaa attttttttt taacaacttt taagttcagg ggtacatgtg     5400

ccagtttgtt tcataggtaa acttacgtca tgggggtttg ttgtatagat gatttcatca     5460

cccaggtgtt aagcctagta cccattagta atttttcctg atcctctccc tcctcctacc     5520

ctccaccctc caatagaccc cagtgtgtgt tgttgccctt tatgtgtcca tgtgttctca     5580

tcatttagct ctcacttatc agtgagaaca actttcatcc cacatctaat ttgtctttct     5640

tcactctggt gtggaaattt tgatagagat tccaatatca cttaaacgtt tcccagaata     5700

tttagataga ataatttagt ttcttctgaa aagtttattt taggctagtg ccacatggtt     5760

gtgaatatta gcatggtagc caaataatag tttgtttaaa tgtatatttc ccaatataaa     5820

tataaggggc atcataattt ttaaaaacta taaaatctag aagaaaaatc tatggataaa     5880

atccataatt ctatcatctg aatgcaatga acattagcat ttaggtatat tttcttgcag     5940

gttttttaac catatactta tagagaatat gtaatttggg tctgtgtttt ttacatataa     6000

atatttttct atgttaaata gtcttcataa gttaattata aagatctgct taatagttct     6060

gctactgcag ttttcattat tagataagtt ggtcattata gttggacatt taggtttaca     6120

atattaaagc agtggtttat atcaatttca gtggtttaaa atatgaattt ctattttgga     6180

atgaaagtat taatttaatg tagtgaatct catattccag aactgagatg attgatttga     6240

tgctatttgt gacagacaga acccataata aagcctttct atgcaagtta cattttatag     6300

aattatccta ctaaaagtaa cctttcttca gcgaatgcaa aacagacctt tggtgttcca     6360

gtatgattca ttttgccatt ctgaacaact atcattttaa ttaagaccat ttaactgaca     6420

cttcctggat tcagttatta agtttcagat tgaaacttga tccagtttaa taactgaatc     6480

cagtttcaca tttatcaatc tgaaaactta gtttgcagat tggtaaatca gggtacttga     6540

caagaataaa tatggtacgc ctttatatat tcatgtgtta catgccagaa atgagtctgt     6600

ttctggaccc tgttcaagga aatagtgatg actgagagag gtacagggaa ataaacaccc     6660

aagggaaaca acagaaataa gcctccccaa ctttctaaaa aactgctcag cattatctct     6720

gtggattctg ggtaaattca gctttttaac atcagctagt cactaatgcc agaaattcca     6780

cttcaagtgt atttattttc ttgtgttaag cattattcta cctggtttat gtctacaatg     6840

tagtattagt gtacttagga ttcttgacac ctcagtgtgc aataaataaa attttgaagt     6900

tgttgttttt catttgaagg tgagaccaca gcccctgagt gctaagggga cctgggaatc     6960

ctaggggaat ggaggtggtg gacgataaga ggatggttga gggcaggagt ttaaaggaca     7020

cagaagctag gagagcagaa aatgtactcc accaccttct gtctaacttg tctcttaaaa     7080

gtgcttttac attttaactt tttaaaaaaa tgtgggccgg gcatagtggc tcatgcctgt     7140

aatcccagca ctttgggagg ccgaggtggg cggatcacct gaggtcaaga gttcaagacc     7200

agcctgacca atatgatgaa accccatctc tactaaaaat acaaaaatag ccaggtgtgg     7260

tggcacatgc ctgtcatccc agctactcag gaggctgagg tgggagaatc gcttgaaccc     7320

gggaggtgga ggttgcagtg agccgagatc atgccattgc actctagcct gggcaacgag     7380

agtgaaactc tgtctcaata aataaataaa taaataaaaa ataaaaaagt gtgaacttaa     7440

atatatttat atgtgtgtac atatattttc ttttttaata ttctggttaa atgagaggcc     7500

atcgggcctc tttttaagag tctaatgatg tgtatatcta atgcccattc cagctggatt     7560

gtaacactgc ttggggaaga taacttaaaa aaaagtagta ccgagattac agcagctagt     7620

gtcctaaatg gaaaagaagt gaaactaaat gtcataggag aaatcctttc agttttgtgc     7680

agtggttcat ttgctgttaa atctacccca ttaccattcc ccttactcct tgaaaataaa     7740

gtgatcttca tgttacagga ccattgcttt atttatgtca cagatttctt gtcctttaat     7800

tagtcagtga aggcacatga ttgcgatact actttttgat tgccgtattg taaaagctat     7860

atggtaaaag gtaactccct ccacccgccc actgcaccct cacgtttagg ggccacacag     7920

aaaaagcgaa ataagatgag gtgaatctaa tgagaaggca actctaatgc ccatcaggag     7980

attcactagg acattttaaa aggacgtctt taaggaaaaa gttttgtttg tagatgttgc     8040

ctctgattcc tccctgcggc tccagtccag gtcttggagc cggccctcga ggggaatgtc     8100

cgggactcgg gtcggtacct ttttggtctg ggaatttcca gtgtgcagaa aaaaaatcca     8160

caaatctagg cctcgctgcc ccctccctgc ctcctctggc cctcctcagt gcccacgcaa     8220

cccggttcga aagagaggat gaccgtattc tgcattttag aaaacaggct cttagcttcc     8280

cccgcccccg tcctcactag agtggagaac tgaaagcgaa cgctataaag ggcgccagtg     8340

agaggggctg gcctcctctt gccacgaggt cagacggcga gttcttagag aaaaaggctg     8400

cttagctgct gcttatcatg taacctcaaa aggaaactga tcgtctttct catgctgtca     8460

cgtacttggg ttattatcgc tgattacagc tggaaacaat tgatttgctc ttacgtattt     8520

gtgtgacttg actcttcaaa cacaaaggta tatttttatt atctgatatt ttattaaaat     8580

atcttaaatg gtaaaaaaaa aaaaaaaaaa                                      8610


<210>  106
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  107
<211>  662
<212>  DNA
<213>  Homo sapiens

<400>  107
ggtgagcggg ggccacagcc cgggctgggg ggagccgggg tgcaagaggg caggctggat       60

caggccgggc agaagcggac cgggctccga gtgtcaacga gagctagaga catgaggctg      120

agctggttcc gggtcctgac agtactgtcc atctgcctga gcgccgtggc cacggccacg      180

ggggccgagg gcaaaaggaa gctgcagatc ggggtcaaga agcgggtgga ccactgtccc      240

atcaaatcgc gcaaagggga tgtcctgcac atgcactaca cggggaagct ggaagatggg      300

acagagtttg acagcagcct gccccagaac cagccctttg tcttctccct tggcacaggc      360

caggtcatca agggctggga ccaggggctg ctggggatgt gtgaggggga aaagcgcaag      420

ctggtgatcc catccgagct agggtatgga gagcggggag ctcccccaaa gattccaggc      480

ggtgcaaccc tggtgttcga ggtggagctg ctcaaaatag agcgacgaac tgagctgtaa      540

ccagactggg gaggggcagg gggagaggcc cccatcaggg accagactgt tccaaaaaaa      600

aaacaaaaaa caaaaacaaa caaaaaaaca cttaaaagcc caaggaaaaa aaaaaaaaaa      660

aa                                                                     662


<210>  108
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  109
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  109
gccggaagtg acgcagggca gcggcgtcgc gggggcgggg ctcgggaaag acccgtgcca       60

gcgggcgtgt ggccgcgggt ttcgcacggt ccaataaggg agggcggcgt ggcccggcct      120

ggtagcgacg aggacgcgcc tgcgcagagg cggcagcacc accggggttg actccggggg      180

cgcggcgagg agagacatga ggctgagctg gttccgggtc ctgacagtac tgtccatctg      240

cctgagcgcc gtggccacgg ccacgggggc cgagggcaaa aggaagctgc agatcggggt      300

caagaagcgg gtggaccact gtcccatcaa atcgcgcaaa ggggatgtcc tgcacatgca      360

ctacacgggg aagctggaag atgggacaga gtttgacagc agcctgcccc agaaccagcc      420

ctttgtcttc tcccttggca caggccaggt catcaagggc tgggaccagg ggctgctggg      480

gatgtgtgag ggggaaaagc gcaagctggt gatcccatcc gagctagggt atggagagcg      540

gggagctccc ccaaagattc caggcggtgc aaccctggtg ttcgaggtgg agctgctcaa      600

aatagagcga cgaactgagc tgtaaccaga ctggggaggg gcagggggag aggcccccat      660

cagggaccag actgttccaa aaaaaaaaca aaaaacaaaa acaaacaaaa aaacacttaa      720

aagcccaagg aaaaaaaaaa aaaaaaa                                          747


<210>  110
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  111
<211>  653
<212>  DNA
<213>  Homo sapiens

<400>  111
gggtgagcaa aggggcgggt ccctggctgc tgtggcctcc cctgaccccc tccccccgct       60

gctggggtcc tcggccaagc ccccttctca ctggactgag acatgaggct gagctggttc      120

cgggtcctga cagtactgtc catctgcctg agcgccgtgg ccacggccac gggggccgag      180

ggcaaaagga agctgcagat cggggtcaag aagcgggtgg accactgtcc catcaaatcg      240

cgcaaagggg atgtcctgca catgcactac acggggaagc tggaagatgg gacagagttt      300

gacagcagcc tgccccagaa ccagcccttt gtcttctccc ttggcacagg ccaggtcatc      360

aagggctggg accaggggct gctggggatg tgtgaggggg aaaagcgcaa gctggtgatc      420

ccatccgagc tagggtatgg agagcgggga gctcccccaa agattccagg cggtgcaacc      480

ctggtgttcg aggtggagct gctcaaaata gagcgacgaa ctgagctgta accagactgg      540

ggaggggcag ggggagaggc ccccatcagg gaccagactg ttccaaaaaa aaaacaaaaa      600

acaaaaacaa acaaaaaaac acttaaaagc ccaaggaaaa aaaaaaaaaa aaa             653


<210>  112
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  113
<211>  6303
<212>  DNA
<213>  Homo sapiens

<400>  113
ctcccggctc cgtagtaagc atggcggcgg cggcgttcgt ggtccctcgg gtgaaacaga       60

aagcgggagc tacgcggaga gggagcgaag agcggggctg aggcggcggc gtcactgcca      120

ggaaacaacc ccaacagtca gcgcgccggc ggccgcggcg gccctgagag ctgactctgc      180

agctgaggta gagagacaac gatcaggaac cctaagaaga ggcgccagag gagccgcctt      240

ctgcctcaga acggcgtgac tcggagaatt ggagcgttat tcagtatatt aatgtcttat      300

tgataatggc agaacatcca ccactactgg atacaactca gatcttaagt agtgatattt      360

ctcttttgtc tgcccctatt gtaagtgcag atggaacaca acaggttatt ctggtacaag      420

ttaacccagg agaagcattt acaataagaa gagaagatgg acagtttcag tgcattacag      480

gtcctgctca ggttccaatg atgtccccaa atggttctgt gcctcctatc tatgtgcctc      540

ctggatatgc cccacaggtt attgaagaca atggtgttcg aagagttgtc gtggtccctc      600

aggcaccaga gtttcaccct ggtagtcaca cagttctcca ccgttctcca catcctcctc      660

tacctggttt cattcctgtc ccaactatga tgccgcctcc accacgtcat atgtactcac      720

ccgtgactgg agctggagac atgacaacac agtatatgcc acagtatcag tcttcacaag      780

tctatggaga tgtagatgct cactctacac atggaaggtc caactttaga gatgaacgat      840

ctagtaaaac atatgaacgt ttgcagaaaa aattgaagga tcgccaagga acacagaaag      900

ataaaatgag cagtccacca tcatcacccc agaaatgccc ttctcccatt aatgaacata      960

atggacttat aaaaggacaa attgctggtg gtataaacac aggatcagca aaaatcaagt     1020

ctgggaaggg gaaaggtggt acacaagttg atacagaaat tgaagaaaaa gatgaagaaa     1080

ctaaagcatt tgaagcactt ctttccaaca ttgtcaaacc agtggcctcc gacatccagg     1140

caaggacagt agtacttacc tggtcaccac cttccagcct cattaatggt gaaacagatg     1200

aaagtagtgt accagagctc tatggttatg aagttctgat ctcaagtact ggaaaagatg     1260

ggaaatacaa aagtgtatat gtaggagaag aaacaaatat cactttaaat gatctcaagc     1320

cagccatgga ttaccatgca aaagtccagg cagaatataa ttctataaag ggaactcctt     1380

cagaggctga aatctttacc accttgagct gtgaacctga tatacctaat ccaccaagga     1440

tagccaatcg gaccaaaaat tcactcactt tgcaatggaa ggcacctagt gacaatggtt     1500

ctaaaatcca aaactttgta ttagaatggg atgaaggaaa aggaaatgga gaattttgtc     1560

agtgttacat gggctcacag aaacaattta aaattactaa actttcacca gcaatgggct     1620

gtaaattcag actatcggcc agaaatgact atggtacaag tggttttagt gaagaagtct     1680

tatattacac ctcaggctgt gctccttcta tgccagcaag tcctgtatta accaaggctg     1740

gaattacttg gttatcctta caatggagta agccctcagg aacaccatca gatgaaggaa     1800

tttcttacat tttagagatg gaggaagaaa cttcaggata tggttttaag cctaaatatg     1860

atggagaaga tcttgcttac acagtgaaaa atctcagacg tagtactaag tataaattta     1920

aggttattgc ttacaactca gaaggtaaaa gtaatccaag tgaagtagta gaatttacta     1980

cttgccctga taaaccaggc atacctgtaa agccttcagt gaaaggaaag atacattcac     2040

acagttttaa aataacctgg gatccaccaa aagacaatgg cggagcaacc atcaataaat     2100

atgtagtgga gatggcagaa ggttctaacg gaaacaaatg ggaaatgata tacagtggtg     2160

ctaccaggga acatctttgt gatcgactga atccaggctg tttctatcgt ttacgagttt     2220

actgcatcag tgatggagga cagagtgcgg tctctgaatc tttacttgtg cagactccag     2280

ctgtgcctcc tggcccatgc ctccctccca gattacaggg tagacccaaa gcaaaagaaa     2340

tacagttacg atggggaccc cctctggttg atggtggatc acccatttcc tgttacagtg     2400

tggaaatgtc tcctatagaa aaagatgaac ctagagaagt ttaccaaggt tctgaagtag     2460

aatgtacagt gagcagcctt cttcctggaa agacatacag cttcagacta cgtgcagcta     2520

acaaaatggg gtttggacca ttttcagaaa aatgtgatat tactacagcc cctgggccac     2580

cagatcagtg caagccccct caagtgacat gtagatctgc aacttgtgca caagtgaatt     2640

gggaggttcc tttgagtaat ggaacagatg tcactgaata tcgactggag tggggaggag     2700

ttgaaggaag tatgcagata tgttactgtg ggcctggtct cagttatgaa ataaaaggac     2760

tttcaccagc aactacctat tattgcaggg tccaggctct gagtgttgtg ggtgcaggcc     2820

ctttcagtga agtagtagcc tgtgtgactc caccatcagt tcctggcatt gtgacctgtc     2880

ttcaagaaat aagcgatgat gagatagaaa atccccatta ttcaccttct acatgccttg     2940

caataagctg ggaaaagcct tgtgatcatg gttcggaaat ccttgcctac agcatagact     3000

ttggagataa acaatcccta acagtgggaa aggttacaag ctatattatc aacaatttgc     3060

aaccagatac aacatacaga atacgaattc aagccttgaa tagccttgga gctggtcctt     3120

tcagccatat gataaaatta aaaactaagc ctctccctcc tgatccacct cgtctggaat     3180

gtgttgcctt tagccaccag aaccttaagc tgaaatgggg agaaggaact ccaaagacat     3240

tgtcaaccga ttctattcag taccaccttc agatggagga taagaatgga cggtttgtat     3300

ccctatacag aggaccatgt catacataca aagtacaaag acttaatgag tcaacatcct     3360

ataaattctg tattcaagct tgtaatgaag ctggggaagg tcccctctcc caagaatata     3420

ttttcactac tccaaaatct gtcccagctg ccttgaaagc ccccaaaata gagaaagtaa     3480

atgatcacat ttgtgaaatt acatgggagt gtttacagcc aatgaaaggt gatccagtta     3540

tttacagtct tcaagttatg ttgggaaaag attcagaatt caaacagatt tacaagggtc     3600

ccgactcttc cttccggtat tccagccttc agctgaactg tgaatatcgc ttccgtgtat     3660

gtgccattcg ccagtgccaa gactctctgg gacaccagga cctcgtaggt ccctacagca     3720

ccacagtgct cttcatctct cagaggactg aaccaccagc cagcaccaac agagacactg     3780

tggaaagcac aaggacccga cgggcactga gtgacgagca gtgtgctgcc gtcatccttg     3840

tgctgtttgc tttcttttcc attttgattg cctttatcat tcagtacttt gtaatcaagt     3900

gaaaatataa ctttattttt taactctatt acattttatt ttgtcatgta ctaaaattat     3960

ttctgtattg cttttataaa aaacagtggc atttagcact ggcattgaga ctatagcaca     4020

tcatttttgc cattttcagt gcttatattg ttaggtagag gctggcactt tattagaatg     4080

caagccacaa aaatatcaat tttgtttttt ttgttagggt gggtcttctt tttttctttc     4140

cctctctctt tttttaacaa atgccttctt atagaaaaac tttctaagag gcaacaattt     4200

agaatggata ttttgacgaa tcggcatgag tgtaacagtg ataacctgat ctgtttgttt     4260

taaagattat taccaagtga aaaattcaga atgaatagaa tttacactaa catgctatat     4320

aaaatgttaa agtctgatgc tgtgaaagca atctagtgct atatttctac ctcctcattt     4380

gtcttaatta tttggtaagt gggattatga tgagtaactg gaggggctta gaaacaaaaa     4440

ctggatgaaa gagtatgcat gaagaaaagc ttctttgata aatgtggagt tcttcattat     4500

aaatatatat tcatgaattc acagataagt acttaaagaa cagacagttt acttggccta     4560

aaaatatttt gatgtttact caaaaagtac ctcttcaggt cttgagaaca tggaaaagaa     4620

ttgagtgctt ttaaatactt tttagaaagt aatcataaaa gtaaattgaa tttcaaacct     4680

atttggcttc tgttttgtga acctttgaac tatatgtatg tgtataaggg tatacacata     4740

catatatggc atataacaag tgtacacata tacacataac aagtgtagaa gtatatatta     4800

catacataca ctcactctgt ctggtatagg ctaattttga agaactccca taagtttctg     4860

ctgcttctcc cataactgct gccaccacca tcagaattca taatcaaacc taaccttttt     4920

gtttggggca ccaaatctga agacaaaatt aatttgcacc agtaaacttc aagctgcttt     4980

ctttcttgaa aactaaacgt ttaacgtata atgtctgttt ggatactgtt ccaaattgtt     5040

gattgcatgt ggttaatgtt gcattagagc actttgcaat tgcataattc attaatgttt     5100

tgtgagcttg catttgtgag ttattggatg atcagactga attttgtcaa gtatcacatt     5160

gtacatcttg cctagatgtc gatgactgca agtaataata cagtttataa tgaaactatc     5220

tacaattctt gttttagcac atctgttatc cgtaaaacac ctgtaactag cttttttaat     5280

ttattatttg aattttagga tagcgaatca ctaattttta gttgctgagg ttggcatttt     5340

agtgattatt aagcacttct gtcagtcttt gaaaaaagaa cgtatttttt gtgctttgaa     5400

gatctctgaa gaatttcttt tataatagaa tgggcatgta ttgtaacagt tttatgtcaa     5460

atgatctgtg ctgtagaaaa acattaaccc ttgttcaaaa aagaaatgga taaacttggc     5520

ctttctaagt ggtaagaatg acctgtcact ataatatact gtatgtttac attttattta     5580

aatttaatct cttatgtata gggtgataac cttccccaga aacaacagtg attgcgattg     5640

ttttctagaa acttctttaa agtgccacat ttggcagtac aaatgagtct gagtgtaata     5700

gcccagagat ttatatatag ttgaatgtct aaaatggtaa aatgtgccac tgtgtcaagt     5760

tacagtggct tatgtttttc atagtaattc aaatgaactt cctatttttg atagtaaatg     5820

tcatttaata gtatacttgc catttgagcc tcactgcaaa attagtgcag aggagaaaac     5880

aatttttaat gtaatcttga ttttacctca tatactgtac attccaaaaa ctctaaactt     5940

tttaaagatt atagatacac taccaaacat atcaccttaa aattgtataa ggctgaatga     6000

acttcataca aatgaaaaaa atctcataaa aatacataaa ctatgtagca aaagtatctg     6060

taaaatccat ggaaaataaa agttgtatca ttctttttga gatacgttta ttgtattcat     6120

atatattcat tatttgctac ctgtttaaga aagtgaaatg ttatggtctc ccctcttcca     6180

atgagcttaa aacatttttc ccaacagtat ataaatcttc aacatgagag gatgtatatt     6240

tattatataa agcccagtaa agaataaaat tagaagtttt atcctaaaaa aaaaaaaaaa     6300

aaa                                                                   6303


<210>  114
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser 
1               5                   10                  15      


Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln 
            20                  25                  30          


Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg 
        35                  40                  45              


Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro 
    50                  55                  60                  


Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly 
65                  70                  75                  80  


Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val 
                85                  90                  95      


Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His 
            100                 105                 110         


Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met 
        115                 120                 125             


Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly 
    130                 135                 140                 


Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr 
145                 150                 155                 160 


Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp 
                165                 170                 175     


Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp 
            180                 185                 190         


Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro 
        195                 200                 205             


Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly 
    210                 215                 220                 


Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser Gly 
225                 230                 235                 240 


Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys Asp 
                245                 250                 255     


Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys Pro 
            260                 265                 270         


Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser Pro 
        275                 280                 285             


Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro Glu 
    290                 295                 300                 


Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly Lys 
305                 310                 315                 320 


Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn Asp 
                325                 330                 335     


Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr Asn 
            340                 345                 350         


Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu Ser 
        355                 360                 365             


Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr Lys 
    370                 375                 380                 


Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser Lys 
385                 390                 395                 400 


Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly Glu 
                405                 410                 415     


Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr Lys 
            420                 425                 430         


Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn Asp 
        435                 440                 445             


Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser Gly 
    450                 455                 460                 


Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly Ile 
465                 470                 475                 480 


Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser Asp 
                485                 490                 495     


Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly Tyr 
            500                 505                 510         


Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val Lys 
        515                 520                 525             


Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr Asn 
    530                 535                 540                 


Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr Cys 
545                 550                 555                 560 


Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys Ile 
                565                 570                 575     


His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn Gly 
            580                 585                 590         


Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser Asn 
        595                 600                 605             


Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His Leu 
    610                 615                 620                 


Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr Cys 
625                 630                 635                 640 


Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val Gln 
                645                 650                 655     


Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln Gly 
            660                 665                 670         


Arg Pro Lys Ala Lys Glu Ile Gln Leu Arg Trp Gly Pro Pro Leu Val 
        675                 680                 685             


Asp Gly Gly Ser Pro Ile Ser Cys Tyr Ser Val Glu Met Ser Pro Ile 
    690                 695                 700                 


Glu Lys Asp Glu Pro Arg Glu Val Tyr Gln Gly Ser Glu Val Glu Cys 
705                 710                 715                 720 


Thr Val Ser Ser Leu Leu Pro Gly Lys Thr Tyr Ser Phe Arg Leu Arg 
                725                 730                 735     


Ala Ala Asn Lys Met Gly Phe Gly Pro Phe Ser Glu Lys Cys Asp Ile 
            740                 745                 750         


Thr Thr Ala Pro Gly Pro Pro Asp Gln Cys Lys Pro Pro Gln Val Thr 
        755                 760                 765             


Cys Arg Ser Ala Thr Cys Ala Gln Val Asn Trp Glu Val Pro Leu Ser 
    770                 775                 780                 


Asn Gly Thr Asp Val Thr Glu Tyr Arg Leu Glu Trp Gly Gly Val Glu 
785                 790                 795                 800 


Gly Ser Met Gln Ile Cys Tyr Cys Gly Pro Gly Leu Ser Tyr Glu Ile 
                805                 810                 815     


Lys Gly Leu Ser Pro Ala Thr Thr Tyr Tyr Cys Arg Val Gln Ala Leu 
            820                 825                 830         


Ser Val Val Gly Ala Gly Pro Phe Ser Glu Val Val Ala Cys Val Thr 
        835                 840                 845             


Pro Pro Ser Val Pro Gly Ile Val Thr Cys Leu Gln Glu Ile Ser Asp 
    850                 855                 860                 


Asp Glu Ile Glu Asn Pro His Tyr Ser Pro Ser Thr Cys Leu Ala Ile 
865                 870                 875                 880 


Ser Trp Glu Lys Pro Cys Asp His Gly Ser Glu Ile Leu Ala Tyr Ser 
                885                 890                 895     


Ile Asp Phe Gly Asp Lys Gln Ser Leu Thr Val Gly Lys Val Thr Ser 
            900                 905                 910         


Tyr Ile Ile Asn Asn Leu Gln Pro Asp Thr Thr Tyr Arg Ile Arg Ile 
        915                 920                 925             


Gln Ala Leu Asn Ser Leu Gly Ala Gly Pro Phe Ser His Met Ile Lys 
    930                 935                 940                 


Leu Lys Thr Lys Pro Leu Pro Pro Asp Pro Pro Arg Leu Glu Cys Val 
945                 950                 955                 960 


Ala Phe Ser His Gln Asn Leu Lys Leu Lys Trp Gly Glu Gly Thr Pro 
                965                 970                 975     


Lys Thr Leu Ser Thr Asp Ser Ile Gln Tyr His Leu Gln Met Glu Asp 
            980                 985                 990         


Lys Asn Gly Arg Phe Val Ser Leu  Tyr Arg Gly Pro Cys  His Thr Tyr 
        995                 1000                 1005             


Lys Val  Gln Arg Leu Asn Glu  Ser Thr Ser Tyr Lys  Phe Cys Ile 
    1010                 1015                 1020             


Gln Ala  Cys Asn Glu Ala Gly  Glu Gly Pro Leu Ser  Gln Glu Tyr 
    1025                 1030                 1035             


Ile Phe  Thr Thr Pro Lys Ser  Val Pro Ala Ala Leu  Lys Ala Pro 
    1040                 1045                 1050             


Lys Ile  Glu Lys Val Asn Asp  His Ile Cys Glu Ile  Thr Trp Glu 
    1055                 1060                 1065             


Cys Leu  Gln Pro Met Lys Gly  Asp Pro Val Ile Tyr  Ser Leu Gln 
    1070                 1075                 1080             


Val Met  Leu Gly Lys Asp Ser  Glu Phe Lys Gln Ile  Tyr Lys Gly 
    1085                 1090                 1095             


Pro Asp  Ser Ser Phe Arg Tyr  Ser Ser Leu Gln Leu  Asn Cys Glu 
    1100                 1105                 1110             


Tyr Arg  Phe Arg Val Cys Ala  Ile Arg Gln Cys Gln  Asp Ser Leu 
    1115                 1120                 1125             


Gly His  Gln Asp Leu Val Gly  Pro Tyr Ser Thr Thr  Val Leu Phe 
    1130                 1135                 1140             


Ile Ser  Gln Arg Thr Glu Pro  Pro Ala Ser Thr Asn  Arg Asp Thr 
    1145                 1150                 1155             


Val Glu  Ser Thr Arg Thr Arg  Arg Ala Leu Ser Asp  Glu Gln Cys 
    1160                 1165                 1170             


Ala Ala  Val Ile Leu Val Leu  Phe Ala Phe Phe Ser  Ile Leu Ile 
    1175                 1180                 1185             


Ala Phe  Ile Ile Gln Tyr Phe  Val Ile Lys 
    1190                 1195             


<210>  115
<211>  6954
<212>  DNA
<213>  Homo sapiens

<400>  115
aagctcgggc gggggagcgg ggcgcggcgg gaaggagcgg gcgacccggt gtgtgggcca       60

gcggagctcc ggaagccagt tgagggaagt tctccatgaa tgtacgtcac aatgatgatg      120

accgaccaaa tccctctgga actgccacca ttgctgaacg gagaggtagc catgatgccc      180

cacttggtga atggagatgc agctcagcag gttattctcg ttcaagttaa tccaggtgag      240

actttcacaa taagagcaga ggatggaaca cttcagtgca ttcaaggacc tgctgaagtt      300

cccatgatgt cacccaatgg atccattcct cccattcatg tgcctccagg ttatatctca      360

caggtgattg aagatagtac tggagtccgc cgggtggtgg tcacacccca gtctcctgag      420

tgttatcccc caagctaccc ctcagccatg tctccaaccc atcatctccc tccctatctg      480

actcaccatc cacattttat tcataactca cacacggctt actacccacc tgttaccgga      540

cctggagata tgccgcctca gttttttccc cagcatcatc ttccccacac aatatatggt      600

gagcaagaaa ttataccatt ttatggaatg tcaacctaca tcacccgaga agaccagtac      660

agcaagcctc cgcacaaaaa actgaaagac cgccagatcg atcgccagaa ccgcctcaac      720

agccctcctt cttctatcta caaaagcagc tgcacaacag tatacaatgg ctatgggaag      780

ggccatagtg gtggaagtgg cggaggcggc agcggtagtg gtcccggaat taagaaaaca      840

gagcgacgag caagaagcag cccaaagtcg aatgattcag acttgcaaga atatgagttg      900

gaagtaaaga gggtgcaaga cattctttcg ggaatagaga aaccacaggt ttctaatatt      960

caggcaagag cagttgtgtt gtcctgggct ccccctgttg gactttcctg tggaccccac     1020

agtggtcttt ccttccccta cagttacgag gtggccttat cagacaaagg acgagatgga     1080

aaatacaaga taatttacag tggagaagaa ttagaatgta acctgaaaga tcttagacca     1140

gcaacagatt atcatgtgag ggtgtatgcc atgtacaatt ccgtaaaggg atcctgctcc     1200

gagcctgtta gcttcaccac ccacagctgt gcacccgagt gtcctttccc ccctaagctg     1260

gcacatagga gcaaaagttc actaaccctg cagtggaagg caccaattga caacggttca     1320

aaaatcacca actacctttt agagtgggat gagggaaaaa gaaatagtgg tttcagacag     1380

tgcttcttcg ggagccagaa gcactgcaag ttgacaaagc tttgtccggc aatggggtac     1440

acattcaggc tggccgctcg aaacgacatt ggtaccagtg gttatagcca agaggtggtg     1500

tgctacacat taggaaatat ccctcagatg ccttctgcac caaggctggt tcgagctggc     1560

atcacatggg tcacgttgca gtggagtaag ccagaaggct gttcacccga ggaagtgatc     1620

acctacacct tggaaattca ggaggatgaa aatgataacc ttttccaccc aaaatacact     1680

ggagaggatt taacctgtac tgtgaaaaat ctcaaaagaa gcacacagta taaattcagg     1740

ctgactgctt ctaatacgga aggaaaaagc tgtccaagcg aagttcttgt ttgtacgacg     1800

agtcctgaca ggcctggacc tcctaccaga ccgcttgtca aaggcccagt tacatctcat     1860

ggctttagtg tcaaatggga tccccctaag gacaatggtg gttcagaaat cctcaagtac     1920

ttgctagaga ttactgatgg aaattctgaa gcgaatcagt gggaagtggc ctacagtggg     1980

tcggctaccg aatacacctt cacccacttg aaaccaggca ctttgtacaa actccgagca     2040

tgctgcatca gtaccggcgg acacagccag tgttctgaaa gtctccctgt tcgcacacta     2100

agcattgcac caggtcaatg tcgaccaccg agggttttgg gtagaccaaa gcacaaagaa     2160

gtccacttag agtgggatgt tcctgcatcg gaaagtggct gtgaggtctc agagtacagc     2220

gtggagatga cggagcccga agacgtagcc tcggaagtgt accatggccc agagctggag     2280

tgcaccgtcg gcaacctgct tcctggaacc gtgtatcgct tccgggtgag ggctctgaat     2340

gatggagggt atggtcccta ttctgatgtc tcagaaatta ccactgctgc agggcctcct     2400

ggacaatgca aagcaccttg tatttcttgt acacctgatg gatgtgtctt agtgggttgg     2460

gagagtcctg atagttctgg tgctgacatc tcagagtaca ggttggaatg gggagaagat     2520

gaagaatcct tagaactcat ttatcatggg acagacaccc gttttgaaat aagagacctg     2580

ttgcctgctg cacagtattg ctgtagacta caggccttca atcaagcagg ggcagggccg     2640

tacagtgaac ttgtcctttg ccagacgcca gcgtctgccc ctgaccccgt ctccactctc     2700

tgtgtcctgg aggaggagcc ccttgatgcc taccctgatt caccttctgc gtgccttgta     2760

ctgaactggg aagagccgtg caataacgga tctgaaatcc ttgcttacac cattgatcta     2820

ggagacacta gcattaccgt gggcaacacc accatgcatg ttatgaaaga tctccttcca     2880

gaaaccacct accggatcag aattcaggct ataaatgaaa ttggagctgg accatttagt     2940

cagttcatta aagcaaaaac tcggccatta ccacccttgc ctcctaggct agaatgtgct     3000

gctgctggtc ctcagagcct gaagctaaaa tggggagaca gtaactccaa gacacatgct     3060

gctgaggaca ttgtgtacac actacagctg gaggacagaa acaagaggtt tatttcaatc     3120

tacagaggac ccagccacac ctacaaggtc cagagactga cggaattcac atgctactcc     3180

ttcagaatcc aggcagcaag cgaggctgga gaagggccct tctcagaaac ctataccttc     3240

agcacaacca aaagtgtccc ccccaccatc aaagcacctc gagtaacaca gttagaagga     3300

aattcatgtg aaattttatg ggagacggta ccatcaatga aaggtgaccc tgttaactac     3360

attctgcagg tattggttgg aagagaatct gagtacaaac aggtgtacaa gggagaagaa     3420

gccacattcc aaatctcagg cctccagacc aacacagact acaggttccg cgtatgtgcg     3480

tgtcgtcgct gtttagacac ctctcaggag ctaagcggag ccttcagccc ctctgcggct     3540

tttgtattac aacgaagtga ggtcatgctt acaggggaca tggggagctt agatgatccc     3600

aaaatgaaga gcatgatgcc tactgatgaa cagtttgcag ccatcattgt gcttggcttt     3660

gcaactttgt ccattttatt tgcctttata ttacagtact tcttaatgaa gtaaacccaa     3720

caaaactaga ggtatgaatt aatgctacac attttaatac acacatttat tcagatactc     3780

ccctttttaa agcccttttg ttttttgatt tatatactct gttttacaga tttagctaga     3840

aaaaaaatgt cagtgttttg gtgcaccttt ttgaaatgca aaactaggaa aaggttaaac     3900

tggatttttt tttttaaaaa aaagaaaaaa aaagaagaaa agtataccag ataccaaaag     3960

ctagctttct tatgttttcc tttaaatttt cagatttacc ttcattctgt tttcactgat     4020

gtcttttgca agcctttgat tttttttttt ttgttacagt ttagtaattt atattcacca     4080

gtcacttcat atgtcttgaa catctgtatc tgtaaacatg aatcaccgtg tgtgtactta     4140

cagggctagg atttcagtgt tgtcagagta ttaccacaca gcaacagcaa catacagaag     4200

atatgttcac tcagataaga ctgccctaaa caaccatttt gtcactcagt tatttaactg     4260

tgtttagctc atttaaatca aaatgtgtac tttaatctaa aatgttttaa taatctgtat     4320

ttcttataat tttaacacta tgagctgcct gtataagaaa tcaagtaacc agaatgcacc     4380

tataaattat ggagcattgt agattttacc acatcaattc atagcagtaa ctttaagagg     4440

gcattgtgca atagttagtt gttttcttgt tcagctattt taaaggctgc tttaacttgt     4500

ttgtttgtct ttgtatataa ctacttctaa tctaatcact agagttatta tattctgtta     4560

tgtttgacca gaattatatg acaagaactg gtgacagttt agtgcctctg cccattgtcc     4620

atgatttaca ctaattgtga gcagtcttct tatgtgtcag ctcattattt ttgaaacatt     4680

tgcctttagg ctgttctttg aggtatcaat gaagtgattg aatttcaata ccttaattca     4740

gtgcacataa tactaatgta acagcagatg aaaattgata aaacccaaaa gagagtcatc     4800

taaatttgta gttcctattt ctgtgggttt gcctggccat ggttggagag ggaatggtgt     4860

ttgatggtaa acacagggtg tttggggatc aaggagccta gattctctcc ctggatctgt     4920

cactaacttg ctgcgtgacc tgaacacgtc actttacctc tctgtgcctc agttttccca     4980

tgcatgaaaa ataaaataaa ataaaacggg gattctaatg tttgtaagtg ctttgagatc     5040

tttgaccaac aggtgctatt ggagtgcaaa gtgttactct tacgtgttta ttttgagtca     5100

tgagataatc aattttaacc caaagtcatt ggattattta tatgaagtcc ataatgttcg     5160

agtacctcag ggacatttaa gagttggagg tgcaaatata ttccaaaagg gtgcaacaga     5220

cacagtgtat ccccctgctt ctgtttttgt atatttttgc tacttggttt ttcttgatca     5280

tagctatttt gtgcttgatc tttattgtct aagatgcagt atcctgtact agcttataat     5340

attcccatac caaagtcatg gggaaacaaa cattattttg tttttggttt atttatacta     5400

tattctgcat acagtacttt aaatgccaat tacagtgcaa tctttattta ttgtaaaatt     5460

ttttaagtgt acttatgtac taattttccc ttgtagcatg ttatattttt gtgttttata     5520

cttttgtaat tttaggtcag tcttgttcct tggcaacatc tgtagtatta ttaatcttct     5580

gacattttct tatgttttta aaaagataag agcatctagt gcattaaatg ccaaaaaaaa     5640

aatacattat cagtgattga aacgtttaca tgtacccaaa aaccataatc atctcttgga     5700

agaaaatgct gagatcaatg aattattctg tgtgcctata ttgacgtagt gagtactaga     5760

gagttctgta ttttattatt gactataata attagtttaa ttagctttgc aaactgatgg     5820

catcaaggta aatatatttt tgccaaagtt ctggccttcc aaaactcacc cccttattta     5880

aatgtgtgct atgacccact atgaccacag catctgcatt ttctaaaaaa ttccatgcag     5940

gtgttttggg gagaggtatt ttttaagcaa tgaaaattca actgagtaca aagccccctc     6000

ttggggggtt ggggaagtct cttttttgaa acacttcaga actgctgcta taaagaaatt     6060

ctctaattgg ttgaattttt tttttaagta aatagtactt taggccaaaa tttatatgaa     6120

tatttgatct tcttgagatt ttcatactat catttaacca ccaggaagct gaagtgtgtg     6180

aagtacaaag ctgacagcac tttattttat tgctctccat tatttggtat tcattatatt     6240

ccttcagtca gaaaattatt actctctatg gcactgtttt ttatcacaaa tatgtatatg     6300

tgatattgat atataactat atatattgcc atcacacacg aacaataaaa taaagtgttc     6360

tattaacctg atctctttgc ccttttgcta tgtgaggagt gaatgagtgg ccttctgatg     6420

ctctgactct tctctgtatg tcaaactcat ccctggcaca agaaattcca gtcatgtgaa     6480

gcaaactgcc ctttgtcctc aaagaaattg ttgaaaaaga aaacttttta aagagatttt     6540

ttgcatattc tctgccttgt tcttatcaac ttgaaatgtt ggcattttct aaccttgttt     6600

tgttggctac aataattcag tattcatgtc aaaattgaga agtgccctaa ttgaatgtgt     6660

ttgaatgtta tccttgcaca attctttaaa ttgaaagata aaatgtttta cctcactgtt     6720

ggacatacat tccaagcttt tcaactctag gagaaaaaga aaatcatgtt ttcctgtatt     6780

gtaaatttta gactatttca tatacattgt attaaaactg ccatatcaat tttaatgtat     6840

agattttgca aatattatgc tatatgtaat acctaactgt atctgtagtg tatatgtaat     6900

atatttatgc ccaataaatg ttttaattct ttctgactta aaaaaaaaaa aaaa           6954


<210>  116
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  117
<211>  7027
<212>  DNA
<213>  Homo sapiens

<400>  117
gcggcggcgg cggctggagg aggagagcgg cggcggcggg agcagcgaag ggggcggcag       60

ggatcctcca ggctgccggc tgggaaggcg tgggcgaccc ggtgtgtggc gcgcccagag      120

ccccgcgttt cagccctagg gaaggaagcc agttgaggga agttctccat gaatgtacgt      180

cacaatgatg atgaccgacc aaatccctct ggaactgcca ccattgctga acggagaggt      240

agccatgatg ccccacttgg tgaatggaga tgcagctcag caggttattc tcgttcaagt      300

taatccaggt gagactttca caataagagc agaggatgga acacttcagt gcattcaagg      360

acctgctgaa gttcccatga tgtcacccaa tggatccatt cctcccattc atgtgcctcc      420

aggttatatc tcacaggtga ttgaagatag tactggagtc cgccgggtgg tggtcacacc      480

ccagtctcct gagtgttatc ccccaagcta cccctcagcc atgtctccaa cccatcatct      540

ccctccctat ctgactcacc atccacattt tattcataac tcacacacgg cttactaccc      600

acctgttacc ggacctggag atatgccgcc tcagtttttt ccccagcatc atcttcccca      660

cacaatatat ggtgagcaag aaattatacc attttatgga atgtcaacct acatcacccg      720

agaagaccag tacagcaagc ctccgcacaa aaaactgaaa gaccgccaga tcgatcgcca      780

gaaccgcctc aacagccctc cttcttctat ctacaaaagc agctgcacaa cagtatacaa      840

tggctatggg aagggccata gtggtggaag tggcggaggc ggcagcggta gtggtcccgg      900

aattaagaaa acagagcgac gagcaagaag cagcccaaag tcgaatgatt cagacttgca      960

agaatatgag ttggaagtaa agagggtgca agacattctt tcgggaatag agaaaccaca     1020

ggtttctaat attcaggcaa gagcagttgt gttgtcctgg gctccccctg ttggactttc     1080

ctgtggaccc cacagtggtc tttccttccc ctacagttac gaggtggcct tatcagacaa     1140

aggacgagat ggaaaataca agataattta cagtggagaa gaattagaat gtaacctgaa     1200

agatcttaga ccagcaacag attatcatgt gagggtgtat gccatgtaca attccgtaaa     1260

gggatcctgc tccgagcctg ttagcttcac cacccacagc tgtgcacccg agtgtccttt     1320

cccccctaag ctggcacata ggagcaaaag ttcactaacc ctgcagtgga aggcaccaat     1380

tgacaacggt tcaaaaatca ccaactacct tttagagtgg gatgagggaa aaagaaatag     1440

tggtttcaga cagtgcttct tcgggagcca gaagcactgc aagttgacaa agctttgtcc     1500

ggcaatgggg tacacattca ggctggccgc tcgaaacgac attggtacca gtggttatag     1560

ccaagaggtg gtgtgctaca cattaggaaa tatccctcag atgccttctg caccaaggct     1620

ggttcgagct ggcatcacat gggtcacgtt gcagtggagt aagccagaag gctgttcacc     1680

cgaggaagtg atcacctaca ccttggaaat tcaggaggat gaaaatgata accttttcca     1740

cccaaaatac actggagagg atttaacctg tactgtgaaa aatctcaaaa gaagcacaca     1800

gtataaattc aggctgactg cttctaatac ggaaggaaaa agctgtccaa gcgaagttct     1860

tgtttgtacg acgagtcctg acaggcctgg acctcctacc agaccgcttg tcaaaggccc     1920

agttacatct catggcttta gtgtcaaatg ggatccccct aaggacaatg gtggttcaga     1980

aatcctcaag tacttgctag agattactga tggaaattct gaagcgaatc agtgggaagt     2040

ggcctacagt gggtcggcta ccgaatacac cttcacccac ttgaaaccag gcactttgta     2100

caaactccga gcatgctgca tcagtaccgg cggacacagc cagtgttctg aaagtctccc     2160

tgttcgcaca ctaagcattg caccaggtca atgtcgacca ccgagggttt tgggtagacc     2220

aaagcacaaa gaagtccact tagagtggga tgttcctgca tcggaaagtg gctgtgaggt     2280

ctcagagtac agcgtggaga tgacggagcc cgaagacgta gcctcggaag tgtaccatgg     2340

cccagagctg gagtgcaccg tcggcaacct gcttcctgga accgtgtatc gcttccgggt     2400

gagggctctg aatgatggag ggtatggtcc ctattctgat gtctcagaaa ttaccactgc     2460

tgcagggcct cctggacaat gcaaagcacc ttgtatttct tgtacacctg atggatgtgt     2520

cttagtgggt tgggagagtc ctgatagttc tggtgctgac atctcagagt acaggttgga     2580

atggggagaa gatgaagaat ccttagaact catttatcat gggacagaca cccgttttga     2640

aataagagac ctgttgcctg ctgcacagta ttgctgtaga ctacaggcct tcaatcaagc     2700

aggggcaggg ccgtacagtg aacttgtcct ttgccagacg ccagcgtctg cccctgaccc     2760

cgtctccact ctctgtgtcc tggaggagga gccccttgat gcctaccctg attcaccttc     2820

tgcgtgcctt gtactgaact gggaagagcc gtgcaataac ggatctgaaa tccttgctta     2880

caccattgat ctaggagaca ctagcattac cgtgggcaac accaccatgc atgttatgaa     2940

agatctcctt ccagaaacca cctaccggat cagaattcag gctataaatg aaattggagc     3000

tggaccattt agtcagttca ttaaagcaaa aactcggcca ttaccaccct tgcctcctag     3060

gctagaatgt gctgctgctg gtcctcagag cctgaagcta aaatggggag acagtaactc     3120

caagacacat gctgctgagg acattgtgta cacactacag ctggaggaca gaaacaagag     3180

gtttatttca atctacagag gacccagcca cacctacaag gtccagagac tgacggaatt     3240

cacatgctac tccttcagaa tccaggcagc aagcgaggct ggagaagggc ccttctcaga     3300

aacctatacc ttcagcacaa ccaaaagtgt cccccccacc atcaaagcac ctcgagtaac     3360

acagttagaa ggaaattcat gtgaaatttt atgggagacg gtaccatcaa tgaaaggtga     3420

ccctgttaac tacattctgc aggtattggt tggaagagaa tctgagtaca aacaggtgta     3480

caagggagaa gaagccacat tccaaatctc aggcctccag accaacacag actacaggtt     3540

ccgcgtatgt gcgtgtcgtc gctgtttaga cacctctcag gagctaagcg gagccttcag     3600

cccctctgcg gcttttgtat tacaacgaag tgaggtcatg cttacagggg acatggggag     3660

cttagatgat cccaaaatga agagcatgat gcctactgat gaacagtttg cagccatcat     3720

tgtgcttggc tttgcaactt tgtccatttt atttgccttt atattacagt acttcttaat     3780

gaagtaaacc caacaaaact agaggtatga attaatgcta cacattttaa tacacacatt     3840

tattcagata ctcccctttt taaagccctt ttgttttttg atttatatac tctgttttac     3900

agatttagct agaaaaaaaa tgtcagtgtt ttggtgcacc tttttgaaat gcaaaactag     3960

gaaaaggtta aactggattt ttttttttaa aaaaaagaaa aaaaaagaag aaaagtatac     4020

cagataccaa aagctagctt tcttatgttt tcctttaaat tttcagattt accttcattc     4080

tgttttcact gatgtctttt gcaagccttt gatttttttt tttttgttac agtttagtaa     4140

tttatattca ccagtcactt catatgtctt gaacatctgt atctgtaaac atgaatcacc     4200

gtgtgtgtac ttacagggct aggatttcag tgttgtcaga gtattaccac acagcaacag     4260

caacatacag aagatatgtt cactcagata agactgccct aaacaaccat tttgtcactc     4320

agttatttaa ctgtgtttag ctcatttaaa tcaaaatgtg tactttaatc taaaatgttt     4380

taataatctg tatttcttat aattttaaca ctatgagctg cctgtataag aaatcaagta     4440

accagaatgc acctataaat tatggagcat tgtagatttt accacatcaa ttcatagcag     4500

taactttaag agggcattgt gcaatagtta gttgttttct tgttcagcta ttttaaaggc     4560

tgctttaact tgtttgtttg tctttgtata taactacttc taatctaatc actagagtta     4620

ttatattctg ttatgtttga ccagaattat atgacaagaa ctggtgacag tttagtgcct     4680

ctgcccattg tccatgattt acactaattg tgagcagtct tcttatgtgt cagctcatta     4740

tttttgaaac atttgccttt aggctgttct ttgaggtatc aatgaagtga ttgaatttca     4800

ataccttaat tcagtgcaca taatactaat gtaacagcag atgaaaattg ataaaaccca     4860

aaagagagtc atctaaattt gtagttccta tttctgtggg tttgcctggc catggttgga     4920

gagggaatgg tgtttgatgg taaacacagg gtgtttgggg atcaaggagc ctagattctc     4980

tccctggatc tgtcactaac ttgctgcgtg acctgaacac gtcactttac ctctctgtgc     5040

ctcagttttc ccatgcatga aaaataaaat aaaataaaac ggggattcta atgtttgtaa     5100

gtgctttgag atctttgacc aacaggtgct attggagtgc aaagtgttac tcttacgtgt     5160

ttattttgag tcatgagata atcaatttta acccaaagtc attggattat ttatatgaag     5220

tccataatgt tcgagtacct cagggacatt taagagttgg aggtgcaaat atattccaaa     5280

agggtgcaac agacacagtg tatccccctg cttctgtttt tgtatatttt tgctacttgg     5340

tttttcttga tcatagctat tttgtgcttg atctttattg tctaagatgc agtatcctgt     5400

actagcttat aatattccca taccaaagtc atggggaaac aaacattatt ttgtttttgg     5460

tttatttata ctatattctg catacagtac tttaaatgcc aattacagtg caatctttat     5520

ttattgtaaa attttttaag tgtacttatg tactaatttt cccttgtagc atgttatatt     5580

tttgtgtttt atacttttgt aattttaggt cagtcttgtt ccttggcaac atctgtagta     5640

ttattaatct tctgacattt tcttatgttt ttaaaaagat aagagcatct agtgcattaa     5700

atgccaaaaa aaaaatacat tatcagtgat tgaaacgttt acatgtaccc aaaaaccata     5760

atcatctctt ggaagaaaat gctgagatca atgaattatt ctgtgtgcct atattgacgt     5820

agtgagtact agagagttct gtattttatt attgactata ataattagtt taattagctt     5880

tgcaaactga tggcatcaag gtaaatatat ttttgccaaa gttctggcct tccaaaactc     5940

acccccttat ttaaatgtgt gctatgaccc actatgacca cagcatctgc attttctaaa     6000

aaattccatg caggtgtttt ggggagaggt attttttaag caatgaaaat tcaactgagt     6060

acaaagcccc ctcttggggg gttggggaag tctctttttt gaaacacttc agaactgctg     6120

ctataaagaa attctctaat tggttgaatt ttttttttaa gtaaatagta ctttaggcca     6180

aaatttatat gaatatttga tcttcttgag attttcatac tatcatttaa ccaccaggaa     6240

gctgaagtgt gtgaagtaca aagctgacag cactttattt tattgctctc cattatttgg     6300

tattcattat attccttcag tcagaaaatt attactctct atggcactgt tttttatcac     6360

aaatatgtat atgtgatatt gatatataac tatatatatt gccatcacac acgaacaata     6420

aaataaagtg ttctattaac ctgatctctt tgcccttttg ctatgtgagg agtgaatgag     6480

tggccttctg atgctctgac tcttctctgt atgtcaaact catccctggc acaagaaatt     6540

ccagtcatgt gaagcaaact gccctttgtc ctcaaagaaa ttgttgaaaa agaaaacttt     6600

ttaaagagat tttttgcata ttctctgcct tgttcttatc aacttgaaat gttggcattt     6660

tctaaccttg ttttgttggc tacaataatt cagtattcat gtcaaaattg agaagtgccc     6720

taattgaatg tgtttgaatg ttatccttgc acaattcttt aaattgaaag ataaaatgtt     6780

ttacctcact gttggacata cattccaagc ttttcaactc taggagaaaa agaaaatcat     6840

gttttcctgt attgtaaatt ttagactatt tcatatacat tgtattaaaa ctgccatatc     6900

aattttaatg tatagatttt gcaaatatta tgctatatgt aatacctaac tgtatctgta     6960

gtgtatatgt aatatattta tgcccaataa atgttttaat tctttctgac ttaaaaaaaa     7020

aaaaaaa                                                               7027


<210>  118
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  119
<211>  5581
<212>  DNA
<213>  Homo sapiens

<400>  119
gaccgctctt tccgggtttg cgagcggaag tggacgaatt tgaatcctgt gggccgttga       60

atgtggctgc tcgcggtcgg cgtgccccga cgtacagcgg gccgggaaaa gtggcactga      120

ggctctggaa cttctgccca gctctccttg taaaatgaat gaaagtaaac ctggtgactc      180

acagaacctt gcttgtgttt tctgtcgaaa acatgatgac tgtcctaata aatacggaga      240

aaagaaaact aaggagaaat ggaatctcac tgtacattac tactgtttgt tgatgtcaag      300

tggaatttgg cagagaggca aagaagaaga aggagtttat ggttttctaa tagaagatat      360

caggaaggaa gtgaatagag cttctaaact gaaatgctgt gtttgcaaga aaaatggtgc      420

ttcaattgga tgtgttgcac cccgatgtaa acgaagttat catttcccat gtggacttca      480

gagagaatgt attttccagt ttactggcaa ttttgcgtca ttttgttggg accatcgacc      540

tgttcaaata attacatcta ataattatag agagtcctta ccatgcacca tttgcttgga      600

atttattgag cctattccaa gttataacat attacgaagt ccttgttgta agaacgcttg      660

gtttcataga gactgtttac aggttcaagc aataaatgcg ggagtgtttt tctttaggtg      720

tacaatatgc aataatagtg acatctttca gaaagagatg ttgagaatgg gaattcatat      780

tcctgaaaaa gatgcttcct gggaattaga ggaaaacgct tatcaagagc ttctgcagca      840

ctatgagcgt tgtgatgttc gaagatgtcg ttgcaaagaa gggcgagact ataatgcacc      900

tgatagcaaa tgggaaataa agcgctgtca gtgttgtggt tccagtggca cacatttagc      960

ctgctcctca ttacggtcat gggagcaaaa ttgggagtgt ttggaatgta ggggtattat     1020

ctacaattca ggagagttcc aaaaagccaa aaaacatgta ttacccaatt ctaataatgt     1080

ggggattaca gattgtttgt tggaagagtc atcacctaaa ttacccagac agtcacctgg     1140

atcccagagt aaagatctac tgaggcaagg cagcaaattt agaagaaatg tatcaacact     1200

attaatagag ttaggattcc aaattaaaaa aaaaactaaa agattgtata tcaacaaagc     1260

caatatctgg aatagtgcct tagatgcatt cagaaatcga aactttaatc cttcatatgc     1320

aattgaagta gcatatgtta ttgaaaatga taattttgga agtgagcatc ctggatcaaa     1380

gcaagaattt ctgagtctct taatgcaaca tcttgagaac tcatcattgt ttgaagggtc     1440

cttgtcaaag aacttgtctc taaattctca agctctgaaa gagaatcttt actatgaagc     1500

tggcaaaatg cttgccattt ctttagttca cggtggtcct tcacctggtt tcttttctaa     1560

aaccttgttt aactgccttg tttatggacc agaaaatacc cagccaattt tagatgatgt     1620

ttcagacttt gatgtggcac agattataat caggataaat actgcaacaa ctgtagctga     1680

cttaaagtca ataataaatg aatgctataa ctaccttgag ttaattggat gtctcagact     1740

tataacgaca ttaagtgata aatatatgtt agtaaaagac atacttggct accatgtaat     1800

tcagagagtc cacacaccct ttgaaagttt taagcagggt ctgaaaaccc ttggtgtttt     1860

ggagaaaatt caggcttatc cagaagcatt ttgtagcatc ctgtgtcata aacctgagag     1920

tctttctgca aaaatcctta gtgagctttt tacagtacac acattacctg atgtgaaagc     1980

tttggggttt tggaacagtt acttacaggc tgttgaagat ggtaaatcta caacaacaat     2040

ggaagacatt cttatttttg caactggttg cagttccatt cctccagctg gatttaaacc     2100

cactccttca attgagtgtc tgcatgtgga ttttcctgtt ggaaacaagt gtaataactg     2160

tttagcaatt cccatcacca atacatataa agagtttcaa gaaaatatgg acttcaccat     2220

aagaaacact ctaagactag aaaaggaaga aagttctcat tacattggac attaaaatgt     2280

ttccttgaac aaagagaagc ttctttaaaa gctgctattg ataactctct tttatttcac     2340

taaccttttc atcatcactt tgaacaaact agttagcttc ttgacctaat aaaatttatg     2400

atatgaatat aaaggaatat tatagccact taggctaaaa aaaggttttt tttgttaaag     2460

catactagtc aaaattggtg ataatttctc attttcttga tatagatact tcataaacct     2520

caatataaat actctcaaaa tggttgtatg gattttattt aggtatggta gcatggttaa     2580

taaaagtaaa aactgtttta ctcacatttt ttgtaaatta ggattacata tagaatgcca     2640

caatttctct aggtttattc aattttcaaa ttattcctca ttttatttta aagcattaaa     2700

tagaaaagct aattggttaa attttgttat ataaatcaga gtcatatatt ctgggatttg     2760

tgttactatg catacttttc taggatgtca ccaaattagt tgtttaaaat gtttttagat     2820

tactgattta tattaagatg acccacactg caattagatt atgcctagtg ggaagtatta     2880

tataaaaagc agaattaagc tgggcacatg tgcttgtaat ctcagttata agggaggctg     2940

aggtgggaga atcgagatac tcagccagcc tggcaatgta gcaaagactc catctcaaaa     3000

aaaaaaacag aattgcacaa attttctgga atctatggac attccatgag cttaaacact     3060

tttgaggtgg ataacattta gttgaaaata cctaagaaag tgtgtcttct ttaaagcctt     3120

ggctttaatc atgggaaatt gttgttgttg ttgttgttgt ttgtatccta tgtttggtat     3180

tctgtatgtc tgatccataa tcattttaga tatttgaatg atctctgtgg attggtaggt     3240

ttggccattt gaccattatt tattatcaag ttggttgtat gctaaggtaa gttgacgcca     3300

tagcattata cagttatctt cattgctctt gaatgatatc tgttatataa gcaatgtata     3360

aataaagtaa aaaggataga atgaaaaacc cattctaatg tcaccactca gagataagta     3420

ccgtatttct gtgtatcctt ctataaactc tttacttctg tttcctttat tttttaactt     3480

taataatgct actaaaagac aatacctaaa agtaactgta ctaacaaagt gctaacaatg     3540

tgaaaatata tagtcccata gtcatgtccc catatttata ctcccacaga agaaaaaatt     3600

ggaaaacaaa gtctgatgtc cttaatctat taacatattt aaatgatata atggttcagt     3660

tttccatgaa agtaaatcat tatgggaagt aaaatgtttt aaccatattt ttcttaatac     3720

acaaagcagg tgtcagctgt tgtattctca cccttcttaa gaaaaatcat tacattattg     3780

atatttttta agtaacagaa tagatttgaa agagataata tatctcttaa taccaaagga     3840

aaactaaaac ataattctag tgtacttttc tttgttccct catgtctttt tcaatctgta     3900

cactaacata cctagcaaat ttgttttact ttaacttgaa atatttaaga acattaaaca     3960

agacatttct ttggctttgg ttgaattttt ttgtctcacc aatagtaatt gaaagatcaa     4020

ttatcaaaga gtttgaatag ctaatataaa ccccaaagtc accatacagt ttttattcca     4080

aatatgttga taaaaagata tttgtttctt tatccacctt atttttatta cagctaaaaa     4140

ccaatacaaa ccaataaaac ctagttaaag ctattttctg gtttttagtt gcaattaatt     4200

tcccctaggg tagaaattaa agctgattaa gtcacacaca catactttgt tggggtgggg     4260

gtggcaggtg gagaggcagt gtacttgggt tagctacaat taaaaacagt atttcaattc     4320

ctcatttgac ttattttata tatagacagg gccttagtga taagatggtg taaataattt     4380

aggatattca tgttttaaag tgaagcataa atatttattt tgcaaaatgt tttctagttt     4440

gaaggatgtt ccattattac catttttaga ttaatctgta tggtcaagga atatcagaga     4500

aacctgtagg ttatttattt tctgcagtgt cattttgtca aatggttggt attataattg     4560

ttcttttctt attaatttta taaccagtgc ataattctta cattagattt taaaaaagaa     4620

ttatgctata aatctttata aatgtgtaca tatatttctt aaatattgca attgcctaaa     4680

tgttgtatat tttaaggctg ttttctcttg ctcttaatgt tgaggaaaac tataaattga     4740

tctataatgc atctactgtt aatggttttg gttagtttga tattcattgt ttttaaacac     4800

tttccaatat ggaaacttta acacctttta tacaattctc tactattcaa gatattcttt     4860

aaaatatctc accagaaact tacaatttta tactttgtaa tttttagttt ctgtaatttg     4920

aggaagtgac tttttttgtt tgggttaagt aaaaagcctt tgattgatta ccagcatgag     4980

aattcacctt ggtttctatt ttatgcattt gtaaattttt cccctaatta tatggaagct     5040

attggaactt ttgtattcag tgctaaatac taagtcaagg ggagtatatt aggtaagttt     5100

tttcagtgac tgtgccttta gcattcagtc attataagaa aatgatcaga acaaaatcat     5160

tacattataa acatgtaatt cttttatata gtgattatca tgtactgcat tgttacttta     5220

aaataagcta ttaaactagt ttttatggtt caagtaatgc aatacaaagt ttcatgcttc     5280

aagtaatgca atacaaaaca taacccattt aatgatgaat tacttgaatg tatattatct     5340

gtggtttagg aaaatttgga ttgtcttgaa gagactcagt tttcaagttc tgattttgac     5400

cattatctct tctaattcat aaacatatcc cagtacctac actatgccag gtattatgct     5460

aggtgatcgt ttatatgtca gcctatttcc ccccctttta aagactgcca gattaaccaa     5520

aaagcgtgac atttataaca atgttttata aataaataaa tgtgtttatg ccactaaagg     5580

t                                                                     5581


<210>  120
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu 
            340                 345                 350         


Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys 
        355                 360                 365             


Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe 
    370                 375                 380                 


Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn 
385                 390                 395                 400 


Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu 
                405                 410                 415     


Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys 
            420                 425                 430         


Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu 
        435                 440                 445             


Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro 
    450                 455                 460                 


Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu 
465                 470                 475                 480 


Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln 
                485                 490                 495     


Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser 
            500                 505                 510         


Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg 
        515                 520                 525             


Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu 
    530                 535                 540                 


Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys 
545                 550                 555                 560 


Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro 
                565                 570                 575     


Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala 
            580                 585                 590         


Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys 
        595                 600                 605             


Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys 
    610                 615                 620                 


Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser 
625                 630                 635                 640 


Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu 
                645                 650                 655     


His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile 
            660                 665                 670         


Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr 
        675                 680                 685             


Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile 
    690                 695                 700                 


Gly His 
705     


<210>  121
<211>  1220
<212>  DNA
<213>  Homo sapiens

<400>  121
agtcccagct cagagccgca acctgcacag ccatgcccgg gcaagaactc aggacggtga       60

atggctctca gatgctcctg gtgttgctgg tgctctcgtg gctgccgcat gggggcgccc      120

tgtctctggc cgaggcgagc cgcgcaagtt tcccgggacc ctcagagttg cactccgaag      180

actccagatt ccgagagttg cggaaacgct acgaggacct gctaaccagg ctgcgggcca      240

accagagctg ggaagattcg aacaccgacc tcgtcccggc ccctgcagtc cggatactca      300

cgccagaagt gcggctggga tccggcggcc acctgcacct gcgtatctct cgggccgccc      360

ttcccgaggg gctccccgag gcctcccgcc ttcaccgggc tctgttccgg ctgtccccga      420

cggcgtcaag gtcgtgggac gtgacacgac cgctgcggcg tcagctcagc cttgcaagac      480

cccaggcgcc cgcgctgcac ctgcgactgt cgccgccgcc gtcgcagtcg gaccaactgc      540

tggcagaatc ttcgtccgca cggccccagc tggagttgca cttgcggccg caagccgcca      600

gggggcgccg cagagcgcgt gcgcgcaacg gggaccactg tccgctcggg cccgggcgtt      660

gctgccgtct gcacacggtc cgcgcgtcgc tggaagacct gggctgggcc gattgggtgc      720

tgtcgccacg ggaggtgcaa gtgaccatgt gcatcggcgc gtgcccgagc cagttccggg      780

cggcaaacat gcacgcgcag atcaagacga gcctgcaccg cctgaagccc gacacggtgc      840

cagcgccctg ctgcgtgccc gccagctaca atcccatggt gctcattcaa aagaccgaca      900

ccggggtgtc gctccagacc tatgatgact tgttagccaa agactgccac tgcatatgag      960

cagtcctggt ccttccactg tgcacctgcg cggaggacgc gacctcagtt gtcctgccct     1020

gtggaatggg ctcaaggttc ctgagacacc cgattcctgc ccaaacagct gtatttatat     1080

aagtctgtta tttattatta atttattggg gtgaccttct tggggactcg ggggctggtc     1140

tgatggaact gtgtatttat ttaaaactct ggtgataaaa ataaagctgt ctgaactgtt     1200

aaaaaaaaaa aaaaaaaaaa                                                 1220


<210>  122
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  123
<211>  6367
<212>  DNA
<213>  Homo sapiens

<400>  123
gaaacgcttc ctggtgctcc tgggcctggc ggttgagccc ggggagctag tctttgcttg       60

ggtaaagaaa gaggactttc cttttttttt ttccttttga gaaaattcag aaatttggag      120

gcacagtagt taggattcag gccaaactgg taaatgacga aggggcttct tccagagcca      180

aggaggaagg gttgtccggc agataatcac cagaatggga gtgaatgact tgtggcaaat      240

tttggagcct gttaagcaac acatcccctt gcgtaatctt ggtgggaaaa ccattgcagt      300

tgatctgagt ctctgggtgt gtgaggcaca gacagtcaaa aaaatgatgg gcagcgtcat      360

gaagccccac ctcaggaact tattttttcg tatctcatat ttaacacaaa tggatgtaaa      420

actggtattt gttatggaag gggaaccacc aaagctgaaa gctgatgtca taagcaagag      480

gaatcagtct cggtatgggt cttctggaaa atcgtggtct cagaaaacag ggagatcaca      540

ttttaaatca gtcttaagag agtgcctcca tatgctcgaa tgcttaggaa tcccctgggt      600

tcaggctgct ggggaagctg aagccatgtg tgcttatctc aatgctggtg gtcatgtcga      660

tggctgcctc accaatgatg gagatacttt cctttatggg gcccagactg tttacaggaa      720

tttcactatg aatacaaagg acccacatgt tgactgttac acaatgtcat ctatcaagag      780

taaactaggt ttggatagag atgctctggt tggattagca atacttcttg gctgtgatta      840

tctcccaaag ggagtccctg gagttggaaa agagcaagca ttaaaactta tacagatttt      900

gaaagggcaa agtttacttc agaggtttaa tcggtggaat gaaacatctt gtaactctag      960

tccacaactg ctagtcacta aaaaactggc tcattgttcc gtatgttccc atccaggttc     1020

acctaaggat catgaacgta atggatgcag attatgtaaa agtgataaat attgtgagcc     1080

acatgactat gaatactgct gtccttgtga gtggcaccgt acagaacatg ataggcaact     1140

cagtgaagta gagaacaata ttaagaagaa agcttgctgt tgtgagggat tcccattcca     1200

tgaggttatt caagaattcc ttttaaacaa ggataaattg gtgaaggtta tcaggtacca     1260

aagacctgat ttgttattgt ttcagagatt tactcttgaa aaaatggagt ggcccaatca     1320

ctatgcatgt gagaaattgc tggtactttt gacccattat gacatgatag aaagaaagct     1380

tggtagcaga aactctaatc aactacagcc aattcgaatt gttaagactc gaatcagaaa     1440

tggagttcat tgttttgaaa tagaatggga aaagcctgaa cattatgcta tggaagataa     1500

acaacatgga gaatttgctt tattaacaat tgaggaagaa tcattgtttg aagcagcata     1560

tcctgagatc gttgctgttt accaaaaaca aaagttagaa attaaaggga agaaacaaaa     1620

acgtattaag cctaaagaaa acaatttgcc agaaccagat gaagtaatga gctttcagtc     1680

acacatgact ttaaaaccca catgtgaaat ctttcataag cagaattcca agttaaattc     1740

ggggatttcc cctgatccta cattaccaca ggaatctatt tctgcctcat tgaatagctt     1800

gcttttacct aaaaatactc catgtttgaa tgcacaagaa cagttcatgt cttctctaag     1860

acctttggct atacagcaaa ttaaagctgt cagtaagtct ctaatttcag aatctagtca     1920

acccaatacc tcatctcata atatatccgt gattgctgat ctacacttga gcactattga     1980

ctgggaaggt acttctttta gtaattctcc agctattcaa aggaatactt tttctcatga     2040

tttaaaatca gaagttgaat cagagctatc agccatccct gatggctttg aaaatatccc     2100

agaacaactg tcctgtgaat cagaaaggta cactgcaaac ataaagaaag tgttggatga     2160

ggattctgat gggattagtc ctgaagagca tctactttct ggcattactg atttatgtct     2220

tcaggatttg cctttaaagg aacgaatatt tacaaaatta tcatatcctc aggataatct     2280

acaaccagat gtcaacctga aaactttgtc catacttagt gtaaaagaat cttgtattgc     2340

taacagtggt tctgattgta catcacatct ttcaaaggat cttccaggaa ttcccttgca     2400

aaatgaatcc agagactcta aaattctaaa aggagaccag ctgcttcaag aagactataa     2460

agtcaatact tctgtccctt attctgtcag taacacagtg gtaaagacct gcaatgttag     2520

accaccaaat actgctttag atcatagtag aaaagttgat atgcaaacca ctcggaaaat     2580

tttaatgaag aagagtgttt gccttgacag acattcctct gatgaacaaa gtgccccagt     2640

gtttgggaaa gctaagtaca caactcaaag aatgaagcac agttctcaaa agcataattc     2700

atcccatttc aaagaaagtg gccataacaa gttgagtagc cctaagatac atattaaaga     2760

aactgaacag tgtgtcagat cttatgaaac agctgaaaat gaagaaagct gtttcccaga     2820

ttcaacaaaa agttctctga gttctctaca atgtcataag aaagaaaaca actctggtac     2880

ttgtttggat agccctcttc ctttacgcca gagattaaaa ctaagattcc aaagcacttg     2940

aaatttaaaa cacttaggta taacttaact attttagtac tatcagcaat agcagagaca     3000

gagggaaggt atctagttca tgtgtggtaa aaattttaat gttctctgtg tcatgaaaca     3060

cttgccattt taatcaaagt tgtaattttt aaaaagtcac ctaaaactct ggttttaaaa     3120

gatcctctgt attgaaaact tctgataatg tatgtcatta tgtccttact attccttaat     3180

tgtagtttta aaatattggt atagtacttg acagagtaaa tacttcatct gattgttcat     3240

ttttactttt tcttccacaa gcctctaaag tatttatatt ccagcttgtt cccaagagga     3300

taattcttta tacttctctt cattctttta aggccttgca aggtcttccg ttataactcg     3360

ctttcctaaa agctattttc tccctcagtg tgaagatacc tttagtgtgc tcttccactt     3420

tggaaggcca tgcaaggtgt tccattataa ctctttttcc taagagttat attctccctc     3480

agtttgaaga tacctttagt gtgctcttcc acttttggtg tcttagtctc ttttgagggg     3540

caaaaataga aaaggagaga agatgtcagt atgtttagta aaaatcatgc tcgtaatggc     3600

tgaataaact gagcaaagta actccttatg tatccccaga agttcacagg tatatcgggt     3660

ggaaaaagat ttggaaaatc aaatgtataa ccaaaaggat tagaaactag cccaggatca     3720

cgtagctaac taataatcct gtgggaatca gttttcttgc ctgctaattt ttttattttt     3780

ctattttttc cttctatagc acttttcccc cttttgtttt gaatctatgc aatattgact     3840

ttaataccac caaatattaa gtcatgcatt aatttaggtc gcactcaaaa attctagaga     3900

ggcatccaga ttgaaaagga aaatggtgtc tgcagatgac aagattgtat gcatcaaaaa     3960

ttctaagaaa tccactagaa aactattaaa actgataaag cgagttcatc caggtcgtag     4020

aatacaagac caatgtgcaa tgatcattgc attttgtttt tgtttgtttg tttttttttg     4080

agacagagtc tcactcttgt cgagactggg gtgtagtggc gccatcttgg ctcactgcaa     4140

cctctgcctc ccaggttcac gcaattcaca tgcctcagcc acctgagtag cagggattac     4200

aggtgtgtgc caccatgcct ggctaatttt tagtattttt agtagagatg ggattttccc     4260

ttgttggtca ggctagtcat gaactcctgg cctcaagcga tccacccatc ttggcctccc     4320

agagtgctgg gattacaggt gtgaatcacc atactcagcc tcaattgtat ttctgtacac     4380

ctctaaataa atggaaatac attccatgtt catgaatcag aagacataag atgaccatac     4440

tccccaaact gatctacagg ttaaatgtaa ttcccattaa ttccagctgg tttctttgct     4500

gattctaaaa ttcatatgga aatttcagga acacagaata ttaggaagaa tcttgaaaga     4560

gtttgaatga cccacccttc ctgattttaa gtatacagaa ctacagtaat gaatgtgttg     4620

tactggtata aaggtagaca tataggtcaa tatagatcaa tggcatagaa ttgagaattc     4680

agaaaaaaag ccttcacgtt tatggtcagt tgattttaaa ccagagtgcc aagacaattc     4740

aatgggaaaa ggaaacagtc tttgaaccaa ctgtcttctg gatctattgg atatctatgt     4800

aaaaaagagt gacatttgat tcctacttca catgatattt aagaagtaac ttaagatgga     4860

tcaaatacct aaatgtaagc taaagctata aaactcttag aagaaaacat agacgtaaat     4920

ctttgtgact ttggattagg caaggatttc ttaaatatac ccaaagcata ggcaacaaaa     4980

gagaatacac aaactggact tcatcaaaac taaaaactgt tgtttgaaat gacaccatca     5040

agaaagtgaa aagacagctt acagaatggg agaaaatatt tgcaaatcat aaatgtgata     5100

agggacttgt atcttggtgg tatataaaga actcgtaact caattataaa aagacaactt     5160

tgaaatgggc aaaatagctc aacaggcttt tctgcaaaga agaaatacaa atgaccaaga     5220

agcacattta aaaattttca gtactattac tcatcaggaa aatgcaaatc aaaaccacaa     5280

gacacccaat gtctacaatc aaaaagataa taactagtat tgatgaggat gtggagaaat     5340

tgaaattctc ataacatgct ggtaggaatg taaaatgggg cagccacttt ggaaaaagtc     5400

tggtagttct tcaaatggtt aaatgtagag ttacgatatg atccagcaat tcctctccca     5460

ggtatatacc caagataaat gaaaacttat atccacataa aaacctgtgc acaaatgtcc     5520

atagcagcgt tattcataat agcctaaaag tggaaacaat cccagttcca gaatgaggaa     5580

ggggagaaac taatgtgtat tagctattgt gtgctaagca ttcaactaga ttatttacaa     5640

accttgtatc atctcaactc tttaaggact gtattgcaat gttttgaata ttcagagaga     5700

aaaaagtcgt tgctaaaaca ttttccaagg ttctgcttat tctgatttgt tcagtcgtgg     5760

ctgtgatagt tcaggaccat ctagaccagg taaataaaat atctagaggc attcttgaga     5820

ttgtatgaga tgaaaataac aaaattagtt gggagtggcc agtctgagtt cattttgcta     5880

tatagctcag gagtccccaa cccctgggct atggacaggt accagtccat cacctgtcag     5940

gaaccggcct gcacagcagg tgttgagcgg catgcaagcg agaattaccg cctgagctct     6000

gcctcctgtc agatcagcgg tggcattaga gtctcatagg agcatgaacc ctattgtgaa     6060

ctacgcatgc gaggatctag tttgtgcact cctactgaga atctaatgcc tgatgatata     6120

aggtggaaca gcttcatccc acagccatct ccccctcatc atccgtggaa aaactgtttt     6180

ccacgaaagt ggtcctcggt gccagaaagg ttggggactg ctgatatacc taatataggc     6240

ataagtgtaa aattatagtt cctcctcctc aaggatttct ctgttttcat tgtccaggtt     6300

ataccaattc tttttaaagc attccatgtt cttgttcctt gatgtggtca tgttatcact     6360

tgtaaat                                                               6367


<210>  124
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Gly Val Asn Asp Leu Trp Gln Ile Leu Glu Pro Val Lys Gln His 
1               5                   10                  15      


Ile Pro Leu Arg Asn Leu Gly Gly Lys Thr Ile Ala Val Asp Leu Ser 
            20                  25                  30          


Leu Trp Val Cys Glu Ala Gln Thr Val Lys Lys Met Met Gly Ser Val 
        35                  40                  45              


Met Lys Pro His Leu Arg Asn Leu Phe Phe Arg Ile Ser Tyr Leu Thr 
    50                  55                  60                  


Gln Met Asp Val Lys Leu Val Phe Val Met Glu Gly Glu Pro Pro Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Val Ile Ser Lys Arg Asn Gln Ser Arg Tyr Gly Ser 
                85                  90                  95      


Ser Gly Lys Ser Trp Ser Gln Lys Thr Gly Arg Ser His Phe Lys Ser 
            100                 105                 110         


Val Leu Arg Glu Cys Leu His Met Leu Glu Cys Leu Gly Ile Pro Trp 
        115                 120                 125             


Val Gln Ala Ala Gly Glu Ala Glu Ala Met Cys Ala Tyr Leu Asn Ala 
    130                 135                 140                 


Gly Gly His Val Asp Gly Cys Leu Thr Asn Asp Gly Asp Thr Phe Leu 
145                 150                 155                 160 


Tyr Gly Ala Gln Thr Val Tyr Arg Asn Phe Thr Met Asn Thr Lys Asp 
                165                 170                 175     


Pro His Val Asp Cys Tyr Thr Met Ser Ser Ile Lys Ser Lys Leu Gly 
            180                 185                 190         


Leu Asp Arg Asp Ala Leu Val Gly Leu Ala Ile Leu Leu Gly Cys Asp 
        195                 200                 205             


Tyr Leu Pro Lys Gly Val Pro Gly Val Gly Lys Glu Gln Ala Leu Lys 
    210                 215                 220                 


Leu Ile Gln Ile Leu Lys Gly Gln Ser Leu Leu Gln Arg Phe Asn Arg 
225                 230                 235                 240 


Trp Asn Glu Thr Ser Cys Asn Ser Ser Pro Gln Leu Leu Val Thr Lys 
                245                 250                 255     


Lys Leu Ala His Cys Ser Val Cys Ser His Pro Gly Ser Pro Lys Asp 
            260                 265                 270         


His Glu Arg Asn Gly Cys Arg Leu Cys Lys Ser Asp Lys Tyr Cys Glu 
        275                 280                 285             


Pro His Asp Tyr Glu Tyr Cys Cys Pro Cys Glu Trp His Arg Thr Glu 
    290                 295                 300                 


His Asp Arg Gln Leu Ser Glu Val Glu Asn Asn Ile Lys Lys Lys Ala 
305                 310                 315                 320 


Cys Cys Cys Glu Gly Phe Pro Phe His Glu Val Ile Gln Glu Phe Leu 
                325                 330                 335     


Leu Asn Lys Asp Lys Leu Val Lys Val Ile Arg Tyr Gln Arg Pro Asp 
            340                 345                 350         


Leu Leu Leu Phe Gln Arg Phe Thr Leu Glu Lys Met Glu Trp Pro Asn 
        355                 360                 365             


His Tyr Ala Cys Glu Lys Leu Leu Val Leu Leu Thr His Tyr Asp Met 
    370                 375                 380                 


Ile Glu Arg Lys Leu Gly Ser Arg Asn Ser Asn Gln Leu Gln Pro Ile 
385                 390                 395                 400 


Arg Ile Val Lys Thr Arg Ile Arg Asn Gly Val His Cys Phe Glu Ile 
                405                 410                 415     


Glu Trp Glu Lys Pro Glu His Tyr Ala Met Glu Asp Lys Gln His Gly 
            420                 425                 430         


Glu Phe Ala Leu Leu Thr Ile Glu Glu Glu Ser Leu Phe Glu Ala Ala 
        435                 440                 445             


Tyr Pro Glu Ile Val Ala Val Tyr Gln Lys Gln Lys Leu Glu Ile Lys 
    450                 455                 460                 


Gly Lys Lys Gln Lys Arg Ile Lys Pro Lys Glu Asn Asn Leu Pro Glu 
465                 470                 475                 480 


Pro Asp Glu Val Met Ser Phe Gln Ser His Met Thr Leu Lys Pro Thr 
                485                 490                 495     


Cys Glu Ile Phe His Lys Gln Asn Ser Lys Leu Asn Ser Gly Ile Ser 
            500                 505                 510         


Pro Asp Pro Thr Leu Pro Gln Glu Ser Ile Ser Ala Ser Leu Asn Ser 
        515                 520                 525             


Leu Leu Leu Pro Lys Asn Thr Pro Cys Leu Asn Ala Gln Glu Gln Phe 
    530                 535                 540                 


Met Ser Ser Leu Arg Pro Leu Ala Ile Gln Gln Ile Lys Ala Val Ser 
545                 550                 555                 560 


Lys Ser Leu Ile Ser Glu Ser Ser Gln Pro Asn Thr Ser Ser His Asn 
                565                 570                 575     


Ile Ser Val Ile Ala Asp Leu His Leu Ser Thr Ile Asp Trp Glu Gly 
            580                 585                 590         


Thr Ser Phe Ser Asn Ser Pro Ala Ile Gln Arg Asn Thr Phe Ser His 
        595                 600                 605             


Asp Leu Lys Ser Glu Val Glu Ser Glu Leu Ser Ala Ile Pro Asp Gly 
    610                 615                 620                 


Phe Glu Asn Ile Pro Glu Gln Leu Ser Cys Glu Ser Glu Arg Tyr Thr 
625                 630                 635                 640 


Ala Asn Ile Lys Lys Val Leu Asp Glu Asp Ser Asp Gly Ile Ser Pro 
                645                 650                 655     


Glu Glu His Leu Leu Ser Gly Ile Thr Asp Leu Cys Leu Gln Asp Leu 
            660                 665                 670         


Pro Leu Lys Glu Arg Ile Phe Thr Lys Leu Ser Tyr Pro Gln Asp Asn 
        675                 680                 685             


Leu Gln Pro Asp Val Asn Leu Lys Thr Leu Ser Ile Leu Ser Val Lys 
    690                 695                 700                 


Glu Ser Cys Ile Ala Asn Ser Gly Ser Asp Cys Thr Ser His Leu Ser 
705                 710                 715                 720 


Lys Asp Leu Pro Gly Ile Pro Leu Gln Asn Glu Ser Arg Asp Ser Lys 
                725                 730                 735     


Ile Leu Lys Gly Asp Gln Leu Leu Gln Glu Asp Tyr Lys Val Asn Thr 
            740                 745                 750         


Ser Val Pro Tyr Ser Val Ser Asn Thr Val Val Lys Thr Cys Asn Val 
        755                 760                 765             


Arg Pro Pro Asn Thr Ala Leu Asp His Ser Arg Lys Val Asp Met Gln 
    770                 775                 780                 


Thr Thr Arg Lys Ile Leu Met Lys Lys Ser Val Cys Leu Asp Arg His 
785                 790                 795                 800 


Ser Ser Asp Glu Gln Ser Ala Pro Val Phe Gly Lys Ala Lys Tyr Thr 
                805                 810                 815     


Thr Gln Arg Met Lys His Ser Ser Gln Lys His Asn Ser Ser His Phe 
            820                 825                 830         


Lys Glu Ser Gly His Asn Lys Leu Ser Ser Pro Lys Ile His Ile Lys 
        835                 840                 845             


Glu Thr Glu Gln Cys Val Arg Ser Tyr Glu Thr Ala Glu Asn Glu Glu 
    850                 855                 860                 


Ser Cys Phe Pro Asp Ser Thr Lys Ser Ser Leu Ser Ser Leu Gln Cys 
865                 870                 875                 880 


His Lys Lys Glu Asn Asn Ser Gly Thr Cys Leu Asp Ser Pro Leu Pro 
                885                 890                 895     


Leu Arg Gln Arg Leu Lys Leu Arg Phe Gln Ser Thr 
            900                 905             


<210>  125
<211>  6226
<212>  DNA
<213>  Homo sapiens

<400>  125
agcgggtggg ggaagctggt aggcacgggc ggctccgcag tgaccggact cgggggagca       60

gataatcacc agaatgggag tgaatgactt gtggcaaatt ttggagcctg ttaagcaaca      120

catccccttg cgtaatcttg gtgggaaaac cattgcagtt gatctgagtc tctgggtgtg      180

tgaggcacag acagtcaaaa aaatgatggg cagcgtcatg aagccccacc tcaggaactt      240

attttttcgt atctcatatt taacacaaat ggatgtaaaa ctggtatttg ttatggaagg      300

ggaaccacca aagctgaaag ctgatgtcat aagcaagagg aatcagtctc ggtatgggtc      360

ttctggaaaa tcgtggtctc agaaaacagg gagatcacat tttaaatcag tcttaagaga      420

gtgcctccat atgctcgaat gcttaggaat cccctgggtt caggctgctg gggaagctga      480

agccatgtgt gcttatctca atgctggtgg tcatgtcgat ggctgcctca ccaatgatgg      540

agatactttc ctttatgggg cccagactgt ttacaggaat ttcactatga atacaaagga      600

cccacatgtt gactgttaca caatgtcatc tatcaagagt aaactaggtt tggatagaga      660

tgctctggtt ggattagcaa tacttcttgg ctgtgattat ctcccaaagg gagtccctgg      720

agttggaaaa gagcaagcat taaaacttat acagattttg aaagggcaaa gtttacttca      780

gaggtttaat cggtggaatg aaacatcttg taactctagt ccacaactgc tagtcactaa      840

aaaactggct cattgttccg tatgttccca tccaggttca cctaaggatc atgaacgtaa      900

tggatgcaga ttatgtaaaa gtgataaata ttgtgagcca catgactatg aatactgctg      960

tccttgtgag tggcaccgta cagaacatga taggcaactc agtgaagtag agaacaatat     1020

taagaagaaa gcttgctgtt gtgagggatt cccattccat gaggttattc aagaattcct     1080

tttaaacaag gataaattgg tgaaggttat caggtaccaa agacctgatt tgttattgtt     1140

tcagagattt actcttgaaa aaatggagtg gcccaatcac tatgcatgtg agaaattgct     1200

ggtacttttg acccattatg acatgataga aagaaagctt ggtagcagaa actctaatca     1260

actacagcca attcgaattg ttaagactcg aatcagaaat ggagttcatt gttttgaaat     1320

agaatgggaa aagcctgaac attatgctat ggaagataaa caacatggag aatttgcttt     1380

attaacaatt gaggaagaat cattgtttga agcagcatat cctgagatcg ttgctgttta     1440

ccaaaaacaa aagttagaaa ttaaagggaa gaaacaaaaa cgtattaagc ctaaagaaaa     1500

caatttgcca gaaccagatg aagtaatgag ctttcagtca cacatgactt taaaacccac     1560

atgtgaaatc tttcataagc agaattccaa gttaaattcg gggatttccc ctgatcctac     1620

attaccacag gaatctattt ctgcctcatt gaatagcttg cttttaccta aaaatactcc     1680

atgtttgaat gcacaagaac agttcatgtc ttctctaaga cctttggcta tacagcaaat     1740

taaagctgtc agtaagtctc taatttcaga atctagtcaa cccaatacct catctcataa     1800

tatatccgtg attgctgatc tacacttgag cactattgac tgggaaggta cttcttttag     1860

taattctcca gctattcaaa ggaatacttt ttctcatgat ttaaaatcag aagttgaatc     1920

agagctatca gccatccctg atggctttga aaatatccca gaacaactgt cctgtgaatc     1980

agaaaggtac actgcaaaca taaagaaagt gttggatgag gattctgatg ggattagtcc     2040

tgaagagcat ctactttctg gcattactga tttatgtctt caggatttgc ctttaaagga     2100

acgaatattt acaaaattat catatcctca ggataatcta caaccagatg tcaacctgaa     2160

aactttgtcc atacttagtg taaaagaatc ttgtattgct aacagtggtt ctgattgtac     2220

atcacatctt tcaaaggatc ttccaggaat tcccttgcaa aatgaatcca gagactctaa     2280

aattctaaaa ggagaccagc tgcttcaaga agactataaa gtcaatactt ctgtccctta     2340

ttctgtcagt aacacagtgg taaagacctg caatgttaga ccaccaaata ctgctttaga     2400

tcatagtaga aaagttgata tgcaaaccac tcggaaaatt ttaatgaaga agagtgtttg     2460

ccttgacaga cattcctctg atgaacaaag tgccccagtg tttgggaaag ctaagtacac     2520

aactcaaaga atgaagcaca gttctcaaaa gcataattca tcccatttca aagaaagtgg     2580

ccataacaag ttgagtagcc ctaagataca tattaaagaa actgaacagt gtgtcagatc     2640

ttatgaaaca gctgaaaatg aagaaagctg tttcccagat tcaacaaaaa gttctctgag     2700

ttctctacaa tgtcataaga aagaaaacaa ctctggtact tgtttggata gccctcttcc     2760

tttacgccag agattaaaac taagattcca aagcacttga aatttaaaac acttaggtat     2820

aacttaacta ttttagtact atcagcaata gcagagacag agggaaggta tctagttcat     2880

gtgtggtaaa aattttaatg ttctctgtgt catgaaacac ttgccatttt aatcaaagtt     2940

gtaattttta aaaagtcacc taaaactctg gttttaaaag atcctctgta ttgaaaactt     3000

ctgataatgt atgtcattat gtccttacta ttccttaatt gtagttttaa aatattggta     3060

tagtacttga cagagtaaat acttcatctg attgttcatt tttacttttt cttccacaag     3120

cctctaaagt atttatattc cagcttgttc ccaagaggat aattctttat acttctcttc     3180

attcttttaa ggccttgcaa ggtcttccgt tataactcgc tttcctaaaa gctattttct     3240

ccctcagtgt gaagatacct ttagtgtgct cttccacttt ggaaggccat gcaaggtgtt     3300

ccattataac tctttttcct aagagttata ttctccctca gtttgaagat acctttagtg     3360

tgctcttcca cttttggtgt cttagtctct tttgaggggc aaaaatagaa aaggagagaa     3420

gatgtcagta tgtttagtaa aaatcatgct cgtaatggct gaataaactg agcaaagtaa     3480

ctccttatgt atccccagaa gttcacaggt atatcgggtg gaaaaagatt tggaaaatca     3540

aatgtataac caaaaggatt agaaactagc ccaggatcac gtagctaact aataatcctg     3600

tgggaatcag ttttcttgcc tgctaatttt tttatttttc tattttttcc ttctatagca     3660

cttttccccc ttttgttttg aatctatgca atattgactt taataccacc aaatattaag     3720

tcatgcatta atttaggtcg cactcaaaaa ttctagagag gcatccagat tgaaaaggaa     3780

aatggtgtct gcagatgaca agattgtatg catcaaaaat tctaagaaat ccactagaaa     3840

actattaaaa ctgataaagc gagttcatcc aggtcgtaga atacaagacc aatgtgcaat     3900

gatcattgca ttttgttttt gtttgtttgt ttttttttga gacagagtct cactcttgtc     3960

gagactgggg tgtagtggcg ccatcttggc tcactgcaac ctctgcctcc caggttcacg     4020

caattcacat gcctcagcca cctgagtagc agggattaca ggtgtgtgcc accatgcctg     4080

gctaattttt agtattttta gtagagatgg gattttccct tgttggtcag gctagtcatg     4140

aactcctggc ctcaagcgat ccacccatct tggcctccca gagtgctggg attacaggtg     4200

tgaatcacca tactcagcct caattgtatt tctgtacacc tctaaataaa tggaaataca     4260

ttccatgttc atgaatcaga agacataaga tgaccatact ccccaaactg atctacaggt     4320

taaatgtaat tcccattaat tccagctggt ttctttgctg attctaaaat tcatatggaa     4380

atttcaggaa cacagaatat taggaagaat cttgaaagag tttgaatgac ccacccttcc     4440

tgattttaag tatacagaac tacagtaatg aatgtgttgt actggtataa aggtagacat     4500

ataggtcaat atagatcaat ggcatagaat tgagaattca gaaaaaaagc cttcacgttt     4560

atggtcagtt gattttaaac cagagtgcca agacaattca atgggaaaag gaaacagtct     4620

ttgaaccaac tgtcttctgg atctattgga tatctatgta aaaaagagtg acatttgatt     4680

cctacttcac atgatattta agaagtaact taagatggat caaataccta aatgtaagct     4740

aaagctataa aactcttaga agaaaacata gacgtaaatc tttgtgactt tggattaggc     4800

aaggatttct taaatatacc caaagcatag gcaacaaaag agaatacaca aactggactt     4860

catcaaaact aaaaactgtt gtttgaaatg acaccatcaa gaaagtgaaa agacagctta     4920

cagaatggga gaaaatattt gcaaatcata aatgtgataa gggacttgta tcttggtggt     4980

atataaagaa ctcgtaactc aattataaaa agacaacttt gaaatgggca aaatagctca     5040

acaggctttt ctgcaaagaa gaaatacaaa tgaccaagaa gcacatttaa aaattttcag     5100

tactattact catcaggaaa atgcaaatca aaaccacaag acacccaatg tctacaatca     5160

aaaagataat aactagtatt gatgaggatg tggagaaatt gaaattctca taacatgctg     5220

gtaggaatgt aaaatggggc agccactttg gaaaaagtct ggtagttctt caaatggtta     5280

aatgtagagt tacgatatga tccagcaatt cctctcccag gtatataccc aagataaatg     5340

aaaacttata tccacataaa aacctgtgca caaatgtcca tagcagcgtt attcataata     5400

gcctaaaagt ggaaacaatc ccagttccag aatgaggaag gggagaaact aatgtgtatt     5460

agctattgtg tgctaagcat tcaactagat tatttacaaa ccttgtatca tctcaactct     5520

ttaaggactg tattgcaatg ttttgaatat tcagagagaa aaaagtcgtt gctaaaacat     5580

tttccaaggt tctgcttatt ctgatttgtt cagtcgtggc tgtgatagtt caggaccatc     5640

tagaccaggt aaataaaata tctagaggca ttcttgagat tgtatgagat gaaaataaca     5700

aaattagttg ggagtggcca gtctgagttc attttgctat atagctcagg agtccccaac     5760

ccctgggcta tggacaggta ccagtccatc acctgtcagg aaccggcctg cacagcaggt     5820

gttgagcggc atgcaagcga gaattaccgc ctgagctctg cctcctgtca gatcagcggt     5880

ggcattagag tctcatagga gcatgaaccc tattgtgaac tacgcatgcg aggatctagt     5940

ttgtgcactc ctactgagaa tctaatgcct gatgatataa ggtggaacag cttcatccca     6000

cagccatctc cccctcatca tccgtggaaa aactgttttc cacgaaagtg gtcctcggtg     6060

ccagaaaggt tggggactgc tgatatacct aatataggca taagtgtaaa attatagttc     6120

ctcctcctca aggatttctc tgttttcatt gtccaggtta taccaattct ttttaaagca     6180

ttccatgttc ttgttccttg atgtggtcat gttatcactt gtaaat                    6226


<210>  126
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Gly Val Asn Asp Leu Trp Gln Ile Leu Glu Pro Val Lys Gln His 
1               5                   10                  15      


Ile Pro Leu Arg Asn Leu Gly Gly Lys Thr Ile Ala Val Asp Leu Ser 
            20                  25                  30          


Leu Trp Val Cys Glu Ala Gln Thr Val Lys Lys Met Met Gly Ser Val 
        35                  40                  45              


Met Lys Pro His Leu Arg Asn Leu Phe Phe Arg Ile Ser Tyr Leu Thr 
    50                  55                  60                  


Gln Met Asp Val Lys Leu Val Phe Val Met Glu Gly Glu Pro Pro Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Val Ile Ser Lys Arg Asn Gln Ser Arg Tyr Gly Ser 
                85                  90                  95      


Ser Gly Lys Ser Trp Ser Gln Lys Thr Gly Arg Ser His Phe Lys Ser 
            100                 105                 110         


Val Leu Arg Glu Cys Leu His Met Leu Glu Cys Leu Gly Ile Pro Trp 
        115                 120                 125             


Val Gln Ala Ala Gly Glu Ala Glu Ala Met Cys Ala Tyr Leu Asn Ala 
    130                 135                 140                 


Gly Gly His Val Asp Gly Cys Leu Thr Asn Asp Gly Asp Thr Phe Leu 
145                 150                 155                 160 


Tyr Gly Ala Gln Thr Val Tyr Arg Asn Phe Thr Met Asn Thr Lys Asp 
                165                 170                 175     


Pro His Val Asp Cys Tyr Thr Met Ser Ser Ile Lys Ser Lys Leu Gly 
            180                 185                 190         


Leu Asp Arg Asp Ala Leu Val Gly Leu Ala Ile Leu Leu Gly Cys Asp 
        195                 200                 205             


Tyr Leu Pro Lys Gly Val Pro Gly Val Gly Lys Glu Gln Ala Leu Lys 
    210                 215                 220                 


Leu Ile Gln Ile Leu Lys Gly Gln Ser Leu Leu Gln Arg Phe Asn Arg 
225                 230                 235                 240 


Trp Asn Glu Thr Ser Cys Asn Ser Ser Pro Gln Leu Leu Val Thr Lys 
                245                 250                 255     


Lys Leu Ala His Cys Ser Val Cys Ser His Pro Gly Ser Pro Lys Asp 
            260                 265                 270         


His Glu Arg Asn Gly Cys Arg Leu Cys Lys Ser Asp Lys Tyr Cys Glu 
        275                 280                 285             


Pro His Asp Tyr Glu Tyr Cys Cys Pro Cys Glu Trp His Arg Thr Glu 
    290                 295                 300                 


His Asp Arg Gln Leu Ser Glu Val Glu Asn Asn Ile Lys Lys Lys Ala 
305                 310                 315                 320 


Cys Cys Cys Glu Gly Phe Pro Phe His Glu Val Ile Gln Glu Phe Leu 
                325                 330                 335     


Leu Asn Lys Asp Lys Leu Val Lys Val Ile Arg Tyr Gln Arg Pro Asp 
            340                 345                 350         


Leu Leu Leu Phe Gln Arg Phe Thr Leu Glu Lys Met Glu Trp Pro Asn 
        355                 360                 365             


His Tyr Ala Cys Glu Lys Leu Leu Val Leu Leu Thr His Tyr Asp Met 
    370                 375                 380                 


Ile Glu Arg Lys Leu Gly Ser Arg Asn Ser Asn Gln Leu Gln Pro Ile 
385                 390                 395                 400 


Arg Ile Val Lys Thr Arg Ile Arg Asn Gly Val His Cys Phe Glu Ile 
                405                 410                 415     


Glu Trp Glu Lys Pro Glu His Tyr Ala Met Glu Asp Lys Gln His Gly 
            420                 425                 430         


Glu Phe Ala Leu Leu Thr Ile Glu Glu Glu Ser Leu Phe Glu Ala Ala 
        435                 440                 445             


Tyr Pro Glu Ile Val Ala Val Tyr Gln Lys Gln Lys Leu Glu Ile Lys 
    450                 455                 460                 


Gly Lys Lys Gln Lys Arg Ile Lys Pro Lys Glu Asn Asn Leu Pro Glu 
465                 470                 475                 480 


Pro Asp Glu Val Met Ser Phe Gln Ser His Met Thr Leu Lys Pro Thr 
                485                 490                 495     


Cys Glu Ile Phe His Lys Gln Asn Ser Lys Leu Asn Ser Gly Ile Ser 
            500                 505                 510         


Pro Asp Pro Thr Leu Pro Gln Glu Ser Ile Ser Ala Ser Leu Asn Ser 
        515                 520                 525             


Leu Leu Leu Pro Lys Asn Thr Pro Cys Leu Asn Ala Gln Glu Gln Phe 
    530                 535                 540                 


Met Ser Ser Leu Arg Pro Leu Ala Ile Gln Gln Ile Lys Ala Val Ser 
545                 550                 555                 560 


Lys Ser Leu Ile Ser Glu Ser Ser Gln Pro Asn Thr Ser Ser His Asn 
                565                 570                 575     


Ile Ser Val Ile Ala Asp Leu His Leu Ser Thr Ile Asp Trp Glu Gly 
            580                 585                 590         


Thr Ser Phe Ser Asn Ser Pro Ala Ile Gln Arg Asn Thr Phe Ser His 
        595                 600                 605             


Asp Leu Lys Ser Glu Val Glu Ser Glu Leu Ser Ala Ile Pro Asp Gly 
    610                 615                 620                 


Phe Glu Asn Ile Pro Glu Gln Leu Ser Cys Glu Ser Glu Arg Tyr Thr 
625                 630                 635                 640 


Ala Asn Ile Lys Lys Val Leu Asp Glu Asp Ser Asp Gly Ile Ser Pro 
                645                 650                 655     


Glu Glu His Leu Leu Ser Gly Ile Thr Asp Leu Cys Leu Gln Asp Leu 
            660                 665                 670         


Pro Leu Lys Glu Arg Ile Phe Thr Lys Leu Ser Tyr Pro Gln Asp Asn 
        675                 680                 685             


Leu Gln Pro Asp Val Asn Leu Lys Thr Leu Ser Ile Leu Ser Val Lys 
    690                 695                 700                 


Glu Ser Cys Ile Ala Asn Ser Gly Ser Asp Cys Thr Ser His Leu Ser 
705                 710                 715                 720 


Lys Asp Leu Pro Gly Ile Pro Leu Gln Asn Glu Ser Arg Asp Ser Lys 
                725                 730                 735     


Ile Leu Lys Gly Asp Gln Leu Leu Gln Glu Asp Tyr Lys Val Asn Thr 
            740                 745                 750         


Ser Val Pro Tyr Ser Val Ser Asn Thr Val Val Lys Thr Cys Asn Val 
        755                 760                 765             


Arg Pro Pro Asn Thr Ala Leu Asp His Ser Arg Lys Val Asp Met Gln 
    770                 775                 780                 


Thr Thr Arg Lys Ile Leu Met Lys Lys Ser Val Cys Leu Asp Arg His 
785                 790                 795                 800 


Ser Ser Asp Glu Gln Ser Ala Pro Val Phe Gly Lys Ala Lys Tyr Thr 
                805                 810                 815     


Thr Gln Arg Met Lys His Ser Ser Gln Lys His Asn Ser Ser His Phe 
            820                 825                 830         


Lys Glu Ser Gly His Asn Lys Leu Ser Ser Pro Lys Ile His Ile Lys 
        835                 840                 845             


Glu Thr Glu Gln Cys Val Arg Ser Tyr Glu Thr Ala Glu Asn Glu Glu 
    850                 855                 860                 


Ser Cys Phe Pro Asp Ser Thr Lys Ser Ser Leu Ser Ser Leu Gln Cys 
865                 870                 875                 880 


His Lys Lys Glu Asn Asn Ser Gly Thr Cys Leu Asp Ser Pro Leu Pro 
                885                 890                 895     


Leu Arg Gln Arg Leu Lys Leu Arg Phe Gln Ser Thr 
            900                 905             


<210>  127
<211>  3705
<212>  DNA
<213>  Homo sapiens

<400>  127
tgaagaccag ctgggagccc actgcctgct gccacctcca actccggccc cctcaccatg       60

cactccctgg acgagccgct cgacctgaag ctgagtatca ccaagctccg ggcggcaaga      120

gagaagcggg agaggacgct gggtgtggtc cggccccgtg ctctgcacag ggagctgggc      180

ctggtggatg acagccccac acctggctct ccaggctccc cgccctcagg cttcctgctg      240

aactccaagt tccccgagaa ggtggaggga cgcttttcag cagcccctct cgtggacctc      300

agcctgtcac caccatctgg gctggactcc cccaatggca gcagctcgct gtcccccgag      360

cgccagggca acggggacct gcctccagtg cccagtgcct cggacttcca gccactgcgc      420

tatttggatg gtgtccccag ctccttccag ttcttcctgc ccctcggctc cgggggggcc      480

ctgcacctgc ctgcctcctc cttccttacc cctcccaagg acaagtgcct ctcgccagac      540

ctgcccctgc ccaagcagct ggtgtgtcgc tgggccaagt gtaaccagct ctttgagctc      600

ctgcaagacc tggtggacca tgtcaacgat taccatgtca agcccgagaa ggatgcgggg      660

tactgctgcc actgggaggg ctgcgcccgc catggccgag gtttcaacgc caggtacaag      720

atgctcatcc acatccgcac acacaccaac gagaagccac accgctgtcc gacctgcagc      780

aagagcttct cccgcctgga gaacctgaag atccacaacc ggtcgcacac aggtgagaag      840

ccctacgtct gcccctacga gggctgcaac aagcgctatt ccaactccag tgaccgcttt      900

aagcacacgc gcacccacta tgtggacaag ccctactact gcaagatgcc cggctgccac      960

aagcgctaca cggaccccag ctcactgcgc aagcacatca aggcccatgg ccactttgtg     1020

tcccacgagc agcaagagct cctgcagctg cgcccacccc ccaagccgcc actgcccgcc     1080

cccgacggcg gcccctatgt cagtggggcc cagatcatca tccccaaccc agctgccctc     1140

tttggaggcc ctggcctgcc cggcttaccc ctacccctgg cccccggccc ccttgacctc     1200

agtgccctgg cctgtggcaa cggtgggggc agtgggggtg gggggggcat gggccctggg     1260

ctgccaggcc ccgtcctgcc tctcaatctg gccaagaacc cgctgctgcc ctcgcccttt     1320

ggggctggcg gactgggctt gcctgtggtc tccctccttg ctggcgcagc tggtggcaag     1380

gccgaggggg agaaggggcg tgggtcggtg cccaccaggg ccctgggcat ggagggccac     1440

aagacgcccc ttgaaaggac ggagagcagc tgctcccggc caagccccga tggactcccc     1500

ctgctgccag gcaccgtgct ggacctgtcc acgggcgtca actcagctgc cagcagccca     1560

gaggcgttgg cccctggctg ggtggtcatc ccgccgggct cggtgctgct caaaccggct     1620

gtggtgaact gagcccatcc tgcggacagt tgtggtgccc ccccggcagc tcccggcact     1680

gcccccgacg aacggaaact cttctgtgaa atagcaataa tgtcctactg cccgggcagc     1740

cccagcccag cccgccggga gcaaggatgg tgctaggtca ttcatggctg gcctcccagc     1800

ccccgggtgg ggacctggcc tgtcatgcag ggagagctgt gctcctgggt gctgaagcct     1860

cgctcctgtc tgtcccccac cacctggccc tcagcttctg agaggctttc ccctgcccga     1920

cctcctcccg tttccctctc ccaccctggc acctccctca cctagtgacc acccatggca     1980

agttgccctc tcccagcaga gggggtgggt ggggtggcat ctgccctccc tgctagcacc     2040

aggctccccc ttcctgagag gagcccccag ggaccagagg cctgcccttc cctcctaggc     2100

ttacccagcc cctgccctgg gggctccttg gacccctttc cctctgaccc tgcctccaga     2160

gggaaagcaa gacagatgca ggcccctgca aagccccagg tagaagcatg ccccccagga     2220

caaggcgcct cccactagtt aggaggaggc ccgctctgca gccgccgtcc tcaccccagg     2280

ccaggcctgc agtaccagac gggatagctg gccactccac ccctgcaccc cagggtctcc     2340

tccctctacc ttttggggca ccctgggagc gtgggaagca ggtccgaggg cccctgagct     2400

ggcaagggga ggtgccaggc cagctgtggt gccaagatac tgagtgacct gggccctggc     2460

tcagggagca tgtggggcca ggcccagcgc cccgtcttcc tccttctacc cccgctgggc     2520

ctggcctggg cagcgccccc tgcagaggcc tttgggtcct tggtcctgta acaggaaggg     2580

ggaggctggc tggggacgac cgaccacagg ctgggacaca gctcctggtc tgggggctcc     2640

aagtgacagc atgcagggga gggggctccc agtcagtgct gtgttgggag ctttctggag     2700

gctgtggact gaaggccttg agggaagcag tggctggagg agggtgctgg acccatgaca     2760

cgttgcttcc tctggctttt ccctgctggg ccgctttctc agaggcactt ccccacccct     2820

aacacccagt gggccccccc aggttctgtg ccactcagag ggaccctggc aggggccaga     2880

accacttaag ggtggtgctg gagggccttg tgccccagtc ccatcccagg acgccctgag     2940

ggatggacgc agccatgcac cccccatctg gggcctctcc ctgctccctc tcccacctgg     3000

cagctgggag ttctggcttc taggcctgcc ctgtcaccag gcctctgagt ggccaggccc     3060

ttccacctcc ccatctgtaa aacgaggcag ctgcccggac agccttgggg tccttagtgg     3120

ccctgcaggt cctctggcag ctctgctgac cccaccctct cccggactgc ccttctgtcc     3180

cagaggggtc accctgaccc ggcccacctt gccactgggc tttggactcc agccctgaca     3240

gggcccagcc acactggctc tgcccctcga aggggctatg agcaaggtag gagggagctg     3300

gtctcctttc ttcgggcccc acccaggccc tgagcacccc ccacccctgt gagggcccca     3360

ggccttaagt ccctggcggg gtcatgggtt tgcgacttga gcagagcgga ggaacagggc     3420

actggaaggc cgacgagctc agcatgcgac tcggtgacgg accaggctcg gcagggccgg     3480

tgtacttttt gtggttgtca ttggtgtgtt gttgcacatt ccaggacgtc agtattttaa     3540

caggttctaa gtgcctttct atcgtagctt atgttttcct cctcttggct ccattgctgt     3600

tagcatagag ttttaaaaaa agagataagc taatgactat aacaatatat tcctccatgg     3660

gagaggaagt ttataaagaa acaataaaag tgagttgcaa agatg                     3705


<210>  128
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  128

Met His Ser Leu Asp Glu Pro Leu Asp Leu Lys Leu Ser Ile Thr Lys 
1               5                   10                  15      


Leu Arg Ala Ala Arg Glu Lys Arg Glu Arg Thr Leu Gly Val Val Arg 
            20                  25                  30          


Pro Arg Ala Leu His Arg Glu Leu Gly Leu Val Asp Asp Ser Pro Thr 
        35                  40                  45              


Pro Gly Ser Pro Gly Ser Pro Pro Ser Gly Phe Leu Leu Asn Ser Lys 
    50                  55                  60                  


Phe Pro Glu Lys Val Glu Gly Arg Phe Ser Ala Ala Pro Leu Val Asp 
65                  70                  75                  80  


Leu Ser Leu Ser Pro Pro Ser Gly Leu Asp Ser Pro Asn Gly Ser Ser 
                85                  90                  95      


Ser Leu Ser Pro Glu Arg Gln Gly Asn Gly Asp Leu Pro Pro Val Pro 
            100                 105                 110         


Ser Ala Ser Asp Phe Gln Pro Leu Arg Tyr Leu Asp Gly Val Pro Ser 
        115                 120                 125             


Ser Phe Gln Phe Phe Leu Pro Leu Gly Ser Gly Gly Ala Leu His Leu 
    130                 135                 140                 


Pro Ala Ser Ser Phe Leu Thr Pro Pro Lys Asp Lys Cys Leu Ser Pro 
145                 150                 155                 160 


Asp Leu Pro Leu Pro Lys Gln Leu Val Cys Arg Trp Ala Lys Cys Asn 
                165                 170                 175     


Gln Leu Phe Glu Leu Leu Gln Asp Leu Val Asp His Val Asn Asp Tyr 
            180                 185                 190         


His Val Lys Pro Glu Lys Asp Ala Gly Tyr Cys Cys His Trp Glu Gly 
        195                 200                 205             


Cys Ala Arg His Gly Arg Gly Phe Asn Ala Arg Tyr Lys Met Leu Ile 
    210                 215                 220                 


His Ile Arg Thr His Thr Asn Glu Lys Pro His Arg Cys Pro Thr Cys 
225                 230                 235                 240 


Ser Lys Ser Phe Ser Arg Leu Glu Asn Leu Lys Ile His Asn Arg Ser 
                245                 250                 255     


His Thr Gly Glu Lys Pro Tyr Val Cys Pro Tyr Glu Gly Cys Asn Lys 
            260                 265                 270         


Arg Tyr Ser Asn Ser Ser Asp Arg Phe Lys His Thr Arg Thr His Tyr 
        275                 280                 285             


Val Asp Lys Pro Tyr Tyr Cys Lys Met Pro Gly Cys His Lys Arg Tyr 
    290                 295                 300                 


Thr Asp Pro Ser Ser Leu Arg Lys His Ile Lys Ala His Gly His Phe 
305                 310                 315                 320 


Val Ser His Glu Gln Gln Glu Leu Leu Gln Leu Arg Pro Pro Pro Lys 
                325                 330                 335     


Pro Pro Leu Pro Ala Pro Asp Gly Gly Pro Tyr Val Ser Gly Ala Gln 
            340                 345                 350         


Ile Ile Ile Pro Asn Pro Ala Ala Leu Phe Gly Gly Pro Gly Leu Pro 
        355                 360                 365             


Gly Leu Pro Leu Pro Leu Ala Pro Gly Pro Leu Asp Leu Ser Ala Leu 
    370                 375                 380                 


Ala Cys Gly Asn Gly Gly Gly Ser Gly Gly Gly Gly Gly Met Gly Pro 
385                 390                 395                 400 


Gly Leu Pro Gly Pro Val Leu Pro Leu Asn Leu Ala Lys Asn Pro Leu 
                405                 410                 415     


Leu Pro Ser Pro Phe Gly Ala Gly Gly Leu Gly Leu Pro Val Val Ser 
            420                 425                 430         


Leu Leu Ala Gly Ala Ala Gly Gly Lys Ala Glu Gly Glu Lys Gly Arg 
        435                 440                 445             


Gly Ser Val Pro Thr Arg Ala Leu Gly Met Glu Gly His Lys Thr Pro 
    450                 455                 460                 


Leu Glu Arg Thr Glu Ser Ser Cys Ser Arg Pro Ser Pro Asp Gly Leu 
465                 470                 475                 480 


Pro Leu Leu Pro Gly Thr Val Leu Asp Leu Ser Thr Gly Val Asn Ser 
                485                 490                 495     


Ala Ala Ser Ser Pro Glu Ala Leu Ala Pro Gly Trp Val Val Ile Pro 
            500                 505                 510         


Pro Gly Ser Val Leu Leu Lys Pro Ala Val Val Asn 
        515                 520                 


<210>  129
<211>  3486
<212>  DNA
<213>  Homo sapiens

<400>  129
gcgctgccgc cagcgaggcc cggggaggcc gcggcggagg cggaggcccg gcgccctggg       60

cggcgccctg tccccgaagt ccgtcctccc cgttaggtgg cgagcgcccg aggggagggg      120

acagccgggc aagcaggaag ctgcggctta aaagggcaac ccgcgcggga cccttcctcc      180

ctagtcgcgg ggagtctgag aaagcgcgcc tgtttcgcga ccatcacgca cctcccctcc      240

gcttgtggcc atgtaccgct acctgggcga agcgctgttg ctgtcccggg ccgggcccgc      300

tgccctgggc tcggcgtccg ccgactcggc cgcgttgctg ggctgggccc ggggacagcc      360

cgccgccgcc ccgcagccgg ggctggcatt ggccgcccgg cgccactaca gcgaggcggt      420

ggccgaccgc gaggacgacc ccaacttctt caagatggtg gagggcttct tcgatcgcgg      480

cgccagcatc gtggaggaca agctggtgga ggacctgagg acccgggaga gcgaggagca      540

gaagcggaac cgggtgcgcg gcatcctgcg gatcatcaag ccctgcaacc atgtgctgag      600

tctctccttc cccatccggc gcgacgacgg ctcctgggag gtcatcgaag gctaccgggc      660

ccagcacagc cagcaccgca cgccctgcaa gggaggtatc cgttacagca ctgatgtgag      720

tgtagatgaa gtaaaagctt tggcttctct gatgacatac aagtgtgcag tggttgatgt      780

gccgtttggg ggtgctaaag ctggtgttaa gatcaatccc aagaactata ctgataatga      840

attggaaaag atcacaagga ggttcaccat ggagctagca aaaaagggct ttattggtcc      900

tggcattgat gtgcctgctc cagacatgag cacaggtgag cgggagatgt cctggatcgc      960

tgatacctat gccagcacca tagggcacta tgatattaat gcacacgcct gtgttactgg     1020

taaacccatc agccaagggg gaatccatgg acgcatctct gctactggcc gtggtgtctt     1080

ccatgggatt gaaaatttca tcaatgaagc ttcttacatg agcattttag gaatgacacc     1140

agggtttgga gataaaacat ttgttgttca gggatttggt aatgtgggcc tacactctat     1200

gagatattta catcgttttg gtgctaaatg tattgctgtt ggtgagtctg atgggagtat     1260

atggaatcca gatggtattg acccaaagga actggaagac ttcaaattgc aacatgggtc     1320

cattctgggc ttccccaagg caaagcccta tgaaggaagc atcttggagg ccgactgtga     1380

catactgatc ccagctgcca gtgagaagca gttgaccaaa tccaacgcac ccagagtcaa     1440

agccaagatc attgctgaag gtgccaatgg gccaacaact ccagaagctg acaagatctt     1500

cctggagaga aacattatgg ttattccaga tctctacttg aatgctggag gagtgacagt     1560

atcttacttt gagtggctga agaatctaaa tcatgtcagc tatggccgtt tgaccttcaa     1620

atatgaaagg gattctaact accacttgct catgtctgtt caagagagtt tagaaagaaa     1680

atttggaaag catggtggaa ctattcccat tgtacccacg gcagagttcc aagacaggat     1740

atcgggtgca tctgagaaag acatcgtgca ctctggcttg gcatacacaa tggagcgttc     1800

tgccaggcaa attatgcgca cagccatgaa gtataacctg ggattggacc tgagaacagc     1860

tgcctatgtt aatgccattg agaaagtctt caaagtgtac aatgaagctg gtgtgacctt     1920

cacatagatg gatcatggct gacttcctca ctatcctctt cacatgtaac ttctgcagac     1980

ctatcacaag tttacatgta accacagaaa tccctttctc tcctgactca ttaataatgg     2040

ataccattct caacaagtca atccaagtca gcccgttaag gagaaagaaa ttaaggttag     2100

cggatcatgt acaagctgag tgtgaaagta gaaatcacct acaccagaga gccattttgg     2160

tattttgcct ttaaataaaa agcctccttt atctggctgt gcagccttgc tctgtggctt     2220

ttcccaacac aatcagtgct agtgctgggg aggaacagtc aagagcagtc agttgcttgc     2280

ttattttttc tggatgagtc tgggacacac tgtaacttta acacatttaa gaagtaggtg     2340

tgtggccttt tcagaaggtg gcatggtcct caagtgagtt cttagtattt tatatcagca     2400

aaataattca attttgcagg ttgcaaacaa atataaaacc tgtttctgtt tatgaatatt     2460

attcttttag aatagaataa gtacatgctg ctgtaataaa attgccttta atcacttaac     2520

aagcctaacc ttgactcaaa cagtgaatgc ctatagaaat aataaatgaa aaaaactagt     2580

atttttatat cataaaacaa tgtcatttat agcttatcat tcatgtattg tccagcagac     2640

attaaaagcc ctgtggataa ttaagttatc ttcatacctg caaaatggtg gaggctattt     2700

tcattaaaac tgtcagaatt tgcttactat aattatgata cagtccaaag aatgcagtca     2760

ctttttatca tgttaactaa ttgttctctt ttgaagatct atggttgact aattaaacaa     2820

taattcaagt agagtgtccc agaaaaaaac cacttgggct ccctgtttgg agtctggctg     2880

gctctgagca ttgccaatgg cccctactca cctgactttg tatcctctcc ttttagaggc     2940

tttgcattct gcacccagct tcactaacag tgggctgaaa acatccttgg gttgagtgtt     3000

tcatttggga gttatttggc cagggccttt tgaacagtag tgtccccatg aagtgctaga     3060

taatatatgt gtaagagtca gctttttttt tttttttaac tctaacaccc ttcagaaatt     3120

tctaactact ttgtaactgc atggcttaac ctggtgataa aagcagttat taaaagtcta     3180

cgttttccaa aacttacgtt tcttttctgt gtttttacat gtggtagttt ctcttttcat     3240

aagttataat actgcaattg gatttctgaa atgtttatag cgaccacctg tataacattt     3300

ccttccactt tattgtgagc tgcccagatt ttattcttga attgtttttt ttttttttgt     3360

tcggtgcttt acacgttcag agaaacttcc cgagtaacga actatagaaa tgatccctga     3420

aagcatagtc tttattctcg aattattttg tattttatta aataatatga acagctaaaa     3480

aaaaaa                                                                3486


<210>  130
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp 
            20                  25                  30          


Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro 
    50                  55                  60                  


Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile 
65                  70                  75                  80  


Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu 
                85                  90                  95      


Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys 
            100                 105                 110         


Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser 
        115                 120                 125             


Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr 
    130                 135                 140                 


Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu 
145                 150                 155                 160 


Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp 
                165                 170                 175     


Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn 
            180                 185                 190         


Tyr Thr Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu 
        195                 200                 205             


Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro 
    210                 215                 220                 


Asp Met Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr 
225                 230                 235                 240 


Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr 
                245                 250                 255     


Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr 
            260                 265                 270         


Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser 
        275                 280                 285             


Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe 
    290                 295                 300                 


Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu 
305                 310                 315                 320 


His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser 
                325                 330                 335     


Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys 
            340                 345                 350         


Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu 
        355                 360                 365             


Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile Leu Ile Pro Ala Ala Ser 
    370                 375                 380                 


Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile 
385                 390                 395                 400 


Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile 
                405                 410                 415     


Phe Leu Glu Arg Asn Ile Met Val Ile Pro Asp Leu Tyr Leu Asn Ala 
            420                 425                 430         


Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His 
        435                 440                 445             


Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr 
    450                 455                 460                 


His Leu Leu Met Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys 
465                 470                 475                 480 


His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Arg 
                485                 490                 495     


Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Gly Leu Ala Tyr 
            500                 505                 510         


Thr Met Glu Arg Ser Ala Arg Gln Ile Met Arg Thr Ala Met Lys Tyr 
        515                 520                 525             


Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu 
    530                 535                 540                 


Lys Val Phe Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr 
545                 550                 555             


<210>  131
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  131
caccccctag tacttccgtt ctccagcgct gggcaccgcg gccggagctg tgggctggca       60

gccatgggtg ccaggcagtg ctgagagcag tggggcatgg ctgcagccct gcaggtcctg      120

ccccgcttgg cccgagcccc cttgcatcca ctcctctggc ggggctcagt ggcccgtctg      180

gccagcagca tggccttggc agagcaggcc aggcagctgt ttgagagtgc tgtaggtgca      240

gtgctgccgg gccccatgct gcaccgggca ctatccttgg accctggtgg cagacagctg      300

aaggtgcggg accggaactt tcagctgagg caaaacctct acctggtggg ctttggcaag      360

gctgtgctgg gtatggcagc tgcagctgag gaactactgg gccagcatct tgtgcagggc      420

gtgatcagcg ttcccaaggg gatccgtgct gccatggagc gtgccggcaa gcaggagatg      480

ctgctgaagc cacatagccg tgtccaggta ttcgagggtg cggaggacaa cctcccggac      540

cgcgatgcgc tgcgggctgc actggccatc cagcaactgg ctgagggact cacagctgat      600

gacctgctgc tcgtgctgat ctcaggtggt gagcctcatc ctgtcagatg tggtggggga      660

ccctgtggag gtgattgcca gtggccccac cgtggccagt tcccacaatg tgcaagattg      720

cctgcatatc ctcaatcgct acggcctccg tgcagccctg ccacgttctg tgaagactgt      780

gctgtctcgg gccgactctg acccccatgg gccacacacc tgtggccatg tcctgaatgt      840

gatcattggc tctaatgtgc tggcgctagc tgaggcccag cggcaggccg aggcactggg      900

ctaccaggct gtggtgctga gtgcagccat gcaaggtgat gtaaaaagta tggcccagtt      960

ctacgggctg ctggcccatg tggctagaac ccgcctcacc ccatccatgg ctggggcttc     1020

tgtggaggaa gatgcacagc tccatgagct ggcagctgag cttcagatcc cagacctgca     1080

gctggaggag gctctggaga ccatggcatg gggaaggggc ccagtctgcc tgctggctgg     1140

tggcgagccc acagtacagc tgcagggctc gggcaggggt ggccggaacc aggaactggc     1200

cctgcgtgtt ggagcagagt tgagaaggtg gccgctgggg ccgatagatg tgctgttttt     1260

gagcggtggc accgatgggc aggatgggcc cacagaggct gctggggcct gggtcacacc     1320

tgagcttgcc agccaggctg cagctgaggg cctggacata gccaccttcc t              1371


<210>  132
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Ala Ala Leu Gln Val Leu Pro Arg Leu Ala Arg Ala Pro Leu 
1               5                   10                  15      


His Pro Leu Leu Trp Arg Gly Ser Val Ala Arg Leu Ala Ser Ser Met 
            20                  25                  30          


Ala Leu Ala Glu Gln Ala Arg Gln Leu Phe Glu Ser Ala Val Gly Ala 
        35                  40                  45              


Val Leu Pro Gly Pro Met Leu His Arg Ala Leu Ser Leu Asp Pro Gly 
    50                  55                  60                  


Gly Arg Gln Leu Lys Val Arg Asp Arg Asn Phe Gln Leu Arg Gln Asn 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Phe Gly Lys Ala Val Leu Gly Met Ala Ala Ala 
                85                  90                  95      


Ala Glu Glu Leu Leu Gly Gln His Leu Val Gln Gly Val Ile Ser Val 
            100                 105                 110         


Pro Lys Gly Ile Arg Ala Ala Met Glu Arg Ala Gly Lys Gln Glu Met 
        115                 120                 125             


Leu Leu Lys Pro His Ser Arg Val Gln Val Phe Glu Gly Ala Glu Asp 
    130                 135                 140                 


Asn Leu Pro Asp Arg Asp Ala Leu Arg Ala Ala Leu Ala Ile Gln Gln 
145                 150                 155                 160 


Leu Ala Glu Gly Leu Thr Ala Asp Asp Leu Leu Leu Val Leu Ile Ser 
                165                 170                 175     


Gly Gly Glu Pro His Pro Val Arg Cys Gly Gly Gly Pro Cys Gly Gly 
            180                 185                 190         


Asp Cys Gln Trp Pro His Arg Gly Gln Phe Pro Gln Cys Ala Arg Leu 
        195                 200                 205             


Pro Ala Tyr Pro Gln Ser Leu Arg Pro Pro Cys Ser Pro Ala Thr Phe 
    210                 215                 220                 


Cys Glu Asp Cys Ala Val Ser Gly Arg Leu 
225                 230                 


<210>  133
<211>  3798
<212>  DNA
<213>  Homo sapiens

<400>  133
caccccctag tacttccgtt ctccagcgct gggcaccgcg gccggagctg tgggctggca       60

gccatgggtg ccaggcagtg ctgagagcag tggggcatgg ctgcagccct gcaggtcctg      120

ccccgcttgg cccgagcccc cttgcatcca ctcctctggc ggggctcagt ggcccgtctg      180

gccagcagca tggccttggc agagcaggcc aggcagctgt ttgagagtgc tgtaggtgca      240

gtgctgccgg gccccatgct gcaccgggca ctatccttgg accctggtgg cagacagctg      300

aaggtgcggg accggaactt tcagctgagg caaaacctct acctggtggg ctttggcaag      360

gctgtgctgg gtatggcagc tgcagctgag gaactactgg gccagcatct tgtgcagggc      420

gtgatcagcg ttcccaaggg gatccgtgct gccatggagc gtgccggcaa gcaggagatg      480

ctgctgaagc cacatagccg tgtccaggta ttcgagggtg cggaggacaa cctcccggac      540

cgcgatgcgc tgcgggctgc actggccatc cagcaactgg ctgagggact cacagctgat      600

gacctgctgc tcgtgctgat ctcaggtggg ggttcagctc tgctgcctgc ccccatccca      660

cctgtcacac tggaggagaa gcagacactc actagactgc tggcagcccg tggagccacc      720

atccaggagt tgaacaccat tcggaaggcc ctgtcccagc tcaagggtgg ggggctggct      780

caggccgcct accctgccca ggtggtgagc ctcatcctgt cagatgtggt gggggaccct      840

gtggaggtga ttgccagtgg ccccaccgtg gccagttccc acaatgtgca agattgcctg      900

catatcctca atcgctacgg cctccgtgca gccctgccac gttctgtgaa gactgtgctg      960

tctcgggccg actctgaccc ccatgggcca cacacctgtg gccatgtcct gaatgtgatc     1020

attggctcta atgtgctggc gctagctgag gcccagcggc aggccgaggc actgggctac     1080

caggctgtgg tgctgagtgc agccatgcaa ggtgatgtaa aaagtatggc ccagttctac     1140

gggctgctgg cccatgtggc tagaacccgc ctcaccccat ccatggctgg ggcttctgtg     1200

gaggaagatg cacagctcca tgagctggca gctgagcttc agatcccaga cctgcagctg     1260

gaggaggctc tggagaccat ggcatgggga aggggcccag tctgcctgct ggctggtggc     1320

gagcccacag tacagctgca gggctcgggc aggggtggcc ggaaccagga actggccctg     1380

cgtgttggag cagagttgag aaggtggccg ctggggccga tagatgtgct gtttttgagc     1440

ggtggcaccg atgggcagga tgggcccaca gaggctgctg gggcctgggt cacacctgag     1500

cttgccagcc aggctgcagc tgagggcctg gacatagcca ccttcctagc ccacaatgac     1560

tcacatacct tcttctgctg cctccagggt ggggcacacc tgctgcacac agggatgaca     1620

ggtaccaatg tcatggacac ccacctcttg ttcctgcggc ctcggtgatg gcataggtca     1680

cattttggga gttcagagga ggcctacaag ggcaaggtca gatggcagag caaggttggt     1740

cctcagggcc tctctaagcc ttagggcccc tcctctcctt ggccttggct gtttggttaa     1800

ctgtcacctt ccactcaggg cctctgctct atatctattc ccttccagcc agactggcag     1860

atgggggctt ccccctaccc ctgaggatga ggacaagccc ctcggccagt tcagcgttcc     1920

cgtgcttctc ccttgggcag cctctctctt gagcccctca ccctgtttct ttctgtgaag     1980

cgagaatgtc tgaaaataaa taggaccatg ccatgggttc tcagtgcgcc ttccctcaga     2040

gtgaggcctc acgggggagc cgctgggagg ggagcgtggt acggctgcag ccacagtacc     2100

agggcctggc aggactctta acacccctct actgggctgg gtacgtgcag gatgtgcctc     2160

gcataacggg agcctgtgcc catccctctg gagtgtgtga gggttgagct tggctcctga     2220

cagctttgat gtgcgtgagc agagacccca gggaggacag gcctaaagac tgcagtctgg     2280

ggtgaccagc cacccaccca cccaaccatg actccaccat ggcactgtca ccatggcttc     2340

tccagcctca gcttgtaggc ctcgttggat ggatgtcctt tctgtctttg gacagccctt     2400

agccacatac tgcacttctg gttgagctga agtttgtccc accccccagt gctgtttcct     2460

tgtgacagcc cttgtcctag gctgaacatc cctagttcct tcagccactc ctctggggac     2520

caagtccaga ccctgaagtc agcccttcag tgggggtccc agcactggga tggtgggtcc     2580

agccagtgat gaggtccagt gacccacacc tcttcctgtg accactggcg ggagaagagg     2640

caagtgggaa tagaggaacg gctgtgttgg cctggccagc agcctgggtt gagagaggga     2700

ggtgccactg tcctgcctcc ttttgagccc ccttgctcag tgtcagaacc ctccgctggc     2760

tgtccccgcc gtgcgccacg gctccaatcc ctatatgagt gagcagtaga atcacatagg     2820

aataaaaagc catagagaac agcgaggcct ggggctgctc ttgcaggcac ttcttccacc     2880

ccaaccctcc cctcctccct gagggtgtgg aggggccctg ggccagggct ggcaggactt     2940

tcccctggga agggtttccc ttccccacct gggctctggg cagcctagct tgcagacagt     3000

tcatgacctg ggggcctggc tcacacaggg caggctggag attgggaggg aggtaaacgt     3060

ggtaagcggg ctctggggac cagggaggtt taggaaaagg ggagcttgca ccccactggg     3120

atgcgcaggc accgcttcct ttccttctgt gctggcatgg agttcctgct gactagggtc     3180

acagtctctg gggttatggt gatcctcgca tgatcctgtg ccgtggtgct cctctggcag     3240

cgtctacatg tagcctgttc ctgcctcagt ccttgctctt gggagcatga gtattggcac     3300

tgggttccaa gttccaggca aaagcaggat aggagagctg gggcaggggc tgcaggagct     3360

gagggcctgg cagccatgtc cccagtgtgt gtgtgggtgg taggtgtgtg agtatacaga     3420

cgttggtgtt ggcgtactca gagtgggaat gcatctctga gtgtacacat agatacttag     3480

tacagggcac atgactccct gcatccctgc tgagggcttt gggtatggat aggatcttgc     3540

aggaggttcc ccctgctcta cattgacccc ttccctatac ttctgtttgt aggggctggg     3600

aggccagggc ccggattgga ccccataggg ccaaatggtc tgtgagccta acccgttaga     3660

tttgctcact ggatacccca gagataagaa aggatgtatt tggccacagt ctaaatgctg     3720

agatgagaaa accctgcaca gtgaatgttt tgataggatt cattacttgc tccataaatg     3780

tcaattttgg atcattga                                                   3798


<210>  134
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Ala Ala Leu Gln Val Leu Pro Arg Leu Ala Arg Ala Pro Leu 
1               5                   10                  15      


His Pro Leu Leu Trp Arg Gly Ser Val Ala Arg Leu Ala Ser Ser Met 
            20                  25                  30          


Ala Leu Ala Glu Gln Ala Arg Gln Leu Phe Glu Ser Ala Val Gly Ala 
        35                  40                  45              


Val Leu Pro Gly Pro Met Leu His Arg Ala Leu Ser Leu Asp Pro Gly 
    50                  55                  60                  


Gly Arg Gln Leu Lys Val Arg Asp Arg Asn Phe Gln Leu Arg Gln Asn 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Phe Gly Lys Ala Val Leu Gly Met Ala Ala Ala 
                85                  90                  95      


Ala Glu Glu Leu Leu Gly Gln His Leu Val Gln Gly Val Ile Ser Val 
            100                 105                 110         


Pro Lys Gly Ile Arg Ala Ala Met Glu Arg Ala Gly Lys Gln Glu Met 
        115                 120                 125             


Leu Leu Lys Pro His Ser Arg Val Gln Val Phe Glu Gly Ala Glu Asp 
    130                 135                 140                 


Asn Leu Pro Asp Arg Asp Ala Leu Arg Ala Ala Leu Ala Ile Gln Gln 
145                 150                 155                 160 


Leu Ala Glu Gly Leu Thr Ala Asp Asp Leu Leu Leu Val Leu Ile Ser 
                165                 170                 175     


Gly Gly Gly Ser Ala Leu Leu Pro Ala Pro Ile Pro Pro Val Thr Leu 
            180                 185                 190         


Glu Glu Lys Gln Thr Leu Thr Arg Leu Leu Ala Ala Arg Gly Ala Thr 
        195                 200                 205             


Ile Gln Glu Leu Asn Thr Ile Arg Lys Ala Leu Ser Gln Leu Lys Gly 
    210                 215                 220                 


Gly Gly Leu Ala Gln Ala Ala Tyr Pro Ala Gln Val Val Ser Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Val Val Gly Asp Pro Val Glu Val Ile Ala Ser Gly Pro 
                245                 250                 255     


Thr Val Ala Ser Ser His Asn Val Gln Asp Cys Leu His Ile Leu Asn 
            260                 265                 270         


Arg Tyr Gly Leu Arg Ala Ala Leu Pro Arg Ser Val Lys Thr Val Leu 
        275                 280                 285             


Ser Arg Ala Asp Ser Asp Pro His Gly Pro His Thr Cys Gly His Val 
    290                 295                 300                 


Leu Asn Val Ile Ile Gly Ser Asn Val Leu Ala Leu Ala Glu Ala Gln 
305                 310                 315                 320 


Arg Gln Ala Glu Ala Leu Gly Tyr Gln Ala Val Val Leu Ser Ala Ala 
                325                 330                 335     


Met Gln Gly Asp Val Lys Ser Met Ala Gln Phe Tyr Gly Leu Leu Ala 
            340                 345                 350         


His Val Ala Arg Thr Arg Leu Thr Pro Ser Met Ala Gly Ala Ser Val 
        355                 360                 365             


Glu Glu Asp Ala Gln Leu His Glu Leu Ala Ala Glu Leu Gln Ile Pro 
    370                 375                 380                 


Asp Leu Gln Leu Glu Glu Ala Leu Glu Thr Met Ala Trp Gly Arg Gly 
385                 390                 395                 400 


Pro Val Cys Leu Leu Ala Gly Gly Glu Pro Thr Val Gln Leu Gln Gly 
                405                 410                 415     


Ser Gly Arg Gly Gly Arg Asn Gln Glu Leu Ala Leu Arg Val Gly Ala 
            420                 425                 430         


Glu Leu Arg Arg Trp Pro Leu Gly Pro Ile Asp Val Leu Phe Leu Ser 
        435                 440                 445             


Gly Gly Thr Asp Gly Gln Asp Gly Pro Thr Glu Ala Ala Gly Ala Trp 
    450                 455                 460                 


Val Thr Pro Glu Leu Ala Ser Gln Ala Ala Ala Glu Gly Leu Asp Ile 
465                 470                 475                 480 


Ala Thr Phe Leu Ala His Asn Asp Ser His Thr Phe Phe Cys Cys Leu 
                485                 490                 495     


Gln Gly Gly Ala His Leu Leu His Thr Gly Met Thr Gly Thr Asn Val 
            500                 505                 510         


Met Asp Thr His Leu Leu Phe Leu Arg Pro Arg 
        515                 520             


<210>  135
<211>  7503
<212>  DNA
<213>  Homo sapiens

<400>  135
ggcgcactct gccggcaacg ccgaggcgct tctgcatctg tgggccgagc attcttcagg       60

tcatctgaac cttctgagaa aacatggtca acgtcttgaa aggagtgctt atagaatgtg      120

atcctgccat gaagcagttt ctgctgtact tggatgagtc caatgccctg gggaagaagt      180

tcatcattca agacattgat gacactcacg tctttgtaat agcagaattg gttaatgtcc      240

tccaggagcg agtgggtgaa ttaatggacc aaaatgcttt ttcccttacc cagaaatgaa      300

aatactcaat atggaccatt taggaattat aagcagcaac tgtgaaagac ttgccactca      360

atatcttagg tgactgatta gacatagagg gttgttttag gagcatgcca cgggaaagac      420

tgagggatca tgatcatttg ttcagaaaaa aagcccctga actgattttg ttaccataga      480

atttaaaaaa aaaaaaagct ttaacagttg gctgtaattt ggcttttatt atcctttatt      540

aaaatacaaa tgtcaatgct tttcctgcct ttttaatacc atgtcagtgt aacataggta      600

tttattttgc tcatccctgt gatctgtgca tttttgctgc gtggatgtga ttgtttggtt      660

tcagttagaa acgtcataga tttgctgttt gaatatgcca aggtggggac ttagacatta      720

tgtacgtctc acaaatccta cctgcatacc agtcagctct attgaggaag acaatgtaaa      780

actaatgtaa actacagttt gcatttccct gaaaacagaa tattgttttt aagagggtta      840

gaaacaacca gtgggaaagg cacatgctgc tttgtttagt ttttccttgt tcaaactttg      900

ttggtcacat tttcccatct gtattctttt ttattaagaa aacagcttag ggaggctgag      960

gtgggaggat tgcttgagcc caggagtccg aggttgctac aaaaacacca ttgcactctg     1020

gcctggacaa cagagagacc ctgcctcaaa aaaaaaaaaa aaaaaaaaaa aaattctact     1080

tgtaccttat tccctatgag aatacttatc aaacttatct aaaaaagaaa aataggaaca     1140

gccatatgca aagtcagccc aacaggaaag gacatattag attaaaatac attgcggcct     1200

gggcttagtg gctcacacct gtaatcccag cactttggga ggctgaggca ggcagatcgc     1260

ttgagtccag gagtcgaaac cctgtctcta caaaaaaaaa aatacaaaaa tctgcctgtt     1320

gtcccagcca ctggggaggc tgaggtagga ggtcaaggct gcagtgaacc ttgatcattg     1380

ctactgccac tccagcctag gtgacagagt gagaccctgt ctccaaaaaa aaaagtgtat     1440

atgtatgtgt gtatatatag caagagagag ttctgtgatc aattgaaggc aaaaacagta     1500

acactgagag gggctttgct tcccttcctg aagatcatgt cattggggtg ggttcctgta     1560

aagggaattt tccaagagaa aagagaattt tcatgacctg tagactctta caaatccatt     1620

ttacctgctt ccttatggta tgtttattca aagcacctgt gtaccatatt tattcactta     1680

cacagcatta ctgaatctgg aaattttcag ttaggtatat tttacataat tcccacccat     1740

ataactcagt ccatacagtt cacagttttc attccctcat agcaatgcaa aaaattttga     1800

tgagttacta ctactaaaac tagttaagta aaagatgatt cttaagaatt tccaggctgg     1860

gcacggtggc tcacgcctgt aatcccagca ctttgggagg ctgaggcagg cagctcacga     1920

ggtcaggaga tcgagaccat cctgctcggt gaaaccccat ctctattaaa aatacaaaaa     1980

attagccggg cctggtggcg ggtgcctgta gtcccatcta ctcaggaggc tgaggcagga     2040

gaatggcgtg aacccgggag gcggagcttg cagtaagctg agattgtgcc actgcactcc     2100

agcctgggcg acagagggag actccatctc aaaaaaaaaa aaaaaaaaaa atgaatttcc     2160

agctatacca aaatgttact aatgtatctt atatttcagg catgtctaaa tcaactttta     2220

gtatgcctca ggcatttgtc accaaccttt tatattaaca tgaaacttag aaaatttttg     2280

atagaatccc agagttcaaa aggtattagg atttttgcca ctgaagtaaa aaagagaaaa     2340

aaagatattt atgagaaaac tattgaacag tgactgtgtt gtacccgagc aagttagagg     2400

aacgccacac tttgagacga atttaaaagt cctttattta gctggcagcc aagaggtggc     2460

tcacacttgg aattctctca gctccgagga aggggcttga ttttccttta tactttggtt     2520

taggaagggg acgggagctc agttgcaaca attctacaga agtaaaaaca tgcaaaaaat     2580

taaaaagaca aatggttaca gagaaacaaa cagttccagg tgcaggggct ctaaatctat     2640

cataagatgt caggtgtggg ggctctgcca gacacaaact caaggcttta tggtgtatct     2700

cttgagcgaa atcctgggaa cttcgtacat tgcttgcttc agtaccttat gagttaattg     2760

gactctttga tatgttgaga gtcagcttac acaagttaac tccttgagga aagggggtgg     2820

gtaaggagtc cttgatgtcc tgtaaatgaa ggaaccaaat ggagttcctc cggctttctc     2880

agctaaggga gagcttattc acatggaaac aaggctaggt gattaaggga gaaagggaca     2940

gtctgaaaac aaggttagta aaaacaaggt taggtattag aactgcaaag agtattaagt     3000

gaaataagtg aaggaaaata tgagctctta tttttaaaaa gttgtgttgg ggcaaatgtt     3060

aaatatcttt ctttctctgg acattattaa gaaagataga gtgatgtgaa tgataggaag     3120

cccacctgta accacttagc tgacatgtcc aactatgggt gaacaggaaa taagcgacat     3180

tcacctaggc tgtttattgg aatctgacta gcattatttg atttggcata ctttacatgt     3240

ccagaacaag gctgttggtg cttggcacca agaaatttat gacttttttt ttttttttaa     3300

ataaagtcct aaaggtagca ttaaaatgac ttaactggag gcaggaggat cactgaagcc     3360

caggagtttg aagctgcagt aagctaagaa ggtgccactg cactgcagcc tggatgacag     3420

agtgaaactt tgtctcttaa tagaactatg gactgaagtt gtgatattga gtgttatatt     3480

tctcaataaa ggttttttct tttaatactg tattaggtca aattcaaggt cttaattcct     3540

tgaattccaa tttccttgtg aaatttcatg tgattaattt aaaattccag ggatcctatc     3600

taacatcaca gttgatggat ataacaatgt attttgagaa atcagttttg gtgaacagta     3660

acagcattac tgataatagg caacaaacac tactgcattt tatttctgat aggcattata     3720

ggtggtaatc caaatgatta atgattttat tgctctttac attttctaga acaggtgatt     3780

tgacataatt gtactttttt ctgagaagtt ggtagtgtac ttactactct attttgcagt     3840

tatacaataa atcttactta gctgacaact aggagtaaaa gctctgacaa aaagcctctg     3900

ctgtaactaa aatactgaga tcattctatc ttaacaaact taacagatgg ggaaggggta     3960

tattttaaag atggagaaat gatgcagttt gcaaatatag tcaataaata ttctcaagtg     4020

tacgtagctc aatttcattt gcagcaaaga taacactgaa atgtctatgg atgagattat     4080

tggataaact tttttaaaaa cactgttctc aagataggca agtgattaag agcactgact     4140

gggccgggcg cggtggctca cgtctataat cctagcactt tgggaggccg aggcgggcaa     4200

atcacaaggt caggagatca aaacaatcct ggctaacaag gtgaaacccc gtctctacta     4260

aaaatacaaa aaaattagct gggcatggtg gtggacgcct gtagtcccag ctactcggga     4320

ggctgaggca ggagaatggt gtaatcccgg gaggtggagg ttgcagtgag ccgagatcgt     4380

gccactgcac tccagccggg gtgacagagc gagactccca cccatctcaa aaaaaataaa     4440

aatgaaaagc actgattgaa tctagattcc ttgagtccaa gtgtcagatc tctgcttact     4500

agctctggga tctcagatgt ttcgttgatt ggatttcttt gtgctcattt gtgtaaacag     4560

gaatgcccgt ctttaaagac tattaaaatg aatgtgagtt aacacacaag aggtcttcaa     4620

aaagttgatg gaaaatgcat attatgaaaa aaattatgca tagatttcaa aaatctttgc     4680

agcaaaataa actcatcatt ataacatgtc tgaacaggat ctagtttgag gcactaagaa     4740

ggatatcagt ttaaatagag cccctgtcag aacaatatga attctgctaa aactgaagca     4800

agaacaaaca tcaaatttat ggcaaagctt aggtggaaga atggtgcaat cattgatgct     4860

ttgcaaaaag tttatgggaa caacgcccca aggaaatcag tttacaaatg gataattcat     4920

tttaagaaag gacaagacaa tgttgaagat gaaacctaca gcagcagacc atgccacttc     4980

gtgaggaaaa aattatctca ttcatgccct acttgaagag gaccaatgat taacagcaga     5040

aacgatagcc aacacaatat gctcctcagt tggttcagct tttataaatc tgactgaaaa     5100

attaaagttg agcacacttt ccactcaatg gataccaaaa ccatccagcc caggtcagct     5160

gcagacaaaa gcagagcttt cgatggaaat gtcaaacaag tgagatcaag atcctgaagc     5220

atttcttcaa agaattgtag caaaaacaga cttttaaaac cttgaattca gagacaggta     5280

taaagactgc ttggtgattt tgaaaggact gagatcattt tgggagagat catcttcaga     5340

aaatgaccag atacaacaag aatttaacat ggcagccaaa ccaacccact aacacacatt     5400

taaataagat acccaaatgc agaaagaaaa gcacagtcgt catgcaaaat agtcactact     5460

cattcaaaaa ctctatagtt gtctgagtcg ttatgctcaa aatatccaat aatatttctt     5520

ttgctgagct gtaaaataat tattttgcaa acataaaaga aaaaaaaaag aattgtaaca     5580

gaaacatggc tttaccagta tgaccctcaa gacaaaatac aaaacaatgg ctaccaagag     5640

gtggaagtgg cccagtcaca gcaagagcag attgatcaag agcaaaggtc atggtaacag     5700

ttttttggat cctcaagtca ttttgcttgt tgactttttg gagggccaaa taaagatatc     5760

atctgcttat tatgagagtg tttcgagaga aatccaaagc ttagcagaga aacgcctggg     5820

aaagcttcac cagagggtct tccaccgtga cagttcccct gcgcattcct ctcataaagc     5880

aagggcagtt tagctagaat ttctatcaaa aatcattagg tatccatctc ccagtcctga     5940

tttggctcct tctgacttct ttttgtttcc caatcttaaa aaaatccctg aagggcacct     6000

gtttttcttc agctaataaa aaagacatgg ttaatttccc aggaccctca gttctttagg     6060

gatagactga atggctggta tcattgcttg aacttaatgg agcttatgtt gagaaataaa     6120

agaaattata ttttattttt atcttttaat tctatttttc catgaacttt ttgaagtccc     6180

ctcagatata aagcagaacg ttatgaaact gagttacctt gaatctagaa gagtacaatg     6240

ataaagggga agatagaaac acacacatat gcgttgtttt ccccactttc acaatgccgt     6300

gcagaaacta acagatgaag gaggagaatc cctaaaaaca gagcattggg tagctagtcc     6360

accagcggtc tgatgctttc attgatctca aaactgtctc tgagtaactc taccaggaaa     6420

gttgtctgga gggttaacat ttctgaaacc atttttatct ttgccttcat tcttgaatga     6480

taattagtct cgaatgtttg gatcacaatc cattgaaaga ctaggctatt ttttcactgt     6540

cctcagacat ttactgagtc cagtttggac tttattttat tttatttttt ttgaaacaag     6600

atctcgctct gttgctcagg ctgaagtgca atagcgcaaa ctcggctcac tgcaacctcc     6660

caggttcaag caattctcgt gcctcagcca tccctatagg catgcgccac cacactttgc     6720

taatcttgta tttttggtag agacggggtt tgcaccatgt tggccaggct ggtctcgaac     6780

tcccaacctc aagtaatctg gcctcccaaa gtggtgggat tacaggcgtg agccagcgcg     6840

cccggcctgg acttaacttc tgaagaactc tttctgttta gattgcagga gcgttctctc     6900

ggctcatctc ttgttttctc acccagctgt tcttcttcta gttggccatc attcttcatc     6960

cctccctccc tttcctgcag ttaattattt ctttgaaatt ttaaaacttc ttaatgttgc     7020

ctggaataca tgagtcttcc tgatctcttc aaacggggtt tgttttgttt tgctttgggg     7080

agaattcttt tgacgttttt gaataagctg ttaacaactt taatacctgt cttgtttgtt     7140

ttcttcagaa atttgttaat tctccatgat tagcaccttt atgtggttat ctcattattt     7200

tcattccttt ttaattctct gttttaggaa tgcttgtcaa attcgtcact aaaattgatt     7260

tactttcttg aaaacctgtt tctgctgctc ccaacatgat ttaatcttgg ctactgagct     7320

tttggttacg ttgcactccc tttaaaatta ctccgtttaa gtacagtgtt cactctttgg     7380

gtaatgtgta caatagaagc ccaatcccca cctataccca atatatccat gggacaagca     7440

tgtacatgca ccccctgagt ctaaaataaa aattttaaaa aaactaaaaa aaaaaaaaaa     7500

aaa                                                                   7503


<210>  136
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Val Asn Val Leu Lys Gly Val Leu Ile Glu Cys Asp Pro Ala Met 
1               5                   10                  15      


Lys Gln Phe Leu Leu Tyr Leu Asp Glu Ser Asn Ala Leu Gly Lys Lys 
            20                  25                  30          


Phe Ile Ile Gln Asp Ile Asp Asp Thr His Val Phe Val Ile Ala Glu 
        35                  40                  45              


Leu Val Asn Val Leu Gln Glu Arg Val Gly Glu Leu Met Asp Gln Asn 
    50                  55                  60                  


Ala Phe Ser Leu Thr Gln Lys 
65                  70      


<210>  137
<211>  1493
<212>  DNA
<213>  Homo sapiens

<400>  137
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggctgatc      180

ccataatgca tcctcaagtg gtcatcttaa gcctcatcct acatctggca gattctgtag      240

ctggttctgt aaaggttggt ggagaggcag gtccatctgt cacactaccc tgccactaca      300

gtggagctgt cacatccatg tgctggaata gaggctcatg ttctctattc acatgccaaa      360

atggcattgt ctggaccaat ggaacccacg tcacctatcg gaaggacaca cgctataagc      420

tattggggga cctttcaaga agggatgtct ctttgaccat agaaaataca gctgtgtctg      480

acagtggcgt atattgttgc cgtgttgagc accgtgggtg gttcaatgac atgaaaatca      540

ccgtatcatt ggagattgtg ccacccaagg tcacgactac tccaattgtc acaactgttc      600

caaccgtcac gactgttcga acgagcacca ctgttccaac gacaacgact gttccaatga      660

cgactgttcc aacgacaact gttccaacaa caatgagcat tccaacgaca acgactgttc      720

tgacgacaat gactgtttca acgacaacga gcgttccaac gacaacgagc attccaacaa      780

caacaagtgt tccagtgaca acaactgtct ctacctttgt tcctccaatg cctttgccca      840

ggcagaacca tgaaccagta gccacttcac catcttcacc tcagccagca gaaacccacc      900

ctacgacact gcagggagca ataaggagag aacccaccag ctcaccattg tactcttaca      960

caacagatgg gaatgacacc gtgacagagt cttcagatgg cctttggaat aacaatcaaa     1020

ctcaactgtt cctagaacat agtctactga cggccaatac cactaaagga atctatgctg     1080

gagtctgtat ttctgtcttg gtgcttcttg ctcttttggg tgtcatcatt gccaaaaagt     1140

atttcttcaa aaaggaggtt caacaactaa gtgtttcatt tagcagcctt caaattaaag     1200

ctttgcaaaa tgcagttgaa aaggaagtcc aagcagaaga caatatctac attgagaata     1260

gtctttatgc cacggactaa gacccagtgg tgctctttga gagtttacgc ccatgagtgc     1320

agaagactga acagacatca gcacatcaga cgtcttttag accccaagac aatttttctg     1380

tttcagtttc atctggcatt ccaacatgtc agtgatactg ggtagagtaa ctctctcact     1440

ccaaactgtg tatagtcaac ctcatcatta atgtagtcct aattttttat gct            1493


<210>  138
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  138

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  139
<211>  1841
<212>  DNA
<213>  Homo sapiens

<400>  139
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggtttgag      180

ccaccgcgcc cggccctgtt tcctttttgt ttgttcccct gataccctgt atcaggacca      240

ggagtcagtt tggcggttat gtgtggggaa gaagctggga agtcaggggc tgtttctgtg      300

gacagctttc cctgtccttt ggaaggcaca gagctctcag ctgcagggaa ctaacagagc      360

tctgaagccg ttatatgtgg tcttctctca tttccagcag agcaggctca tatgaatcaa      420

ccaactgggt gaaaagataa gttgcaatct gagatttaag acttgatcag ataccatctg      480

gtggagggta ccaaccagcc tgtctgctca ttttccttca ggctgatccc ataatgcatc      540

ctcaagtggt catcttaagc ctcatcctac atctggcaga ttctgtagct ggttctgtaa      600

aggttggtgg agaggcaggt ccatctgtca cactaccctg ccactacagt ggagctgtca      660

catccatgtg ctggaataga ggctcatgtt ctctattcac atgccaaaat ggcattgtct      720

ggaccaatgg aacccacgtc acctatcgga aggacacacg ctataagcta ttgggggacc      780

tttcaagaag ggatgtctct ttgaccatag aaaatacagc tgtgtctgac agtggcgtat      840

attgttgccg tgttgagcac cgtgggtggt tcaatgacat gaaaatcacc gtatcattgg      900

agattgtgcc acccaaggtc acgactactc caattgtcac aactgttcca accgtcacga      960

ctgttcgaac gagcaccact gttccaacga caacgactgt tccaatgacg actgttccaa     1020

cgacaactgt tccaacaaca atgagcattc caacgacaac gactgttctg acgacaatga     1080

ctgtttcaac gacaacgagc gttccaacga caacgagcat tccaacaaca acaagtgttc     1140

cagtgacaac aactgtctct acctttgttc ctccaatgcc tttgcccagg cagaaccatg     1200

aaccagtagc cacttcacca tcttcacctc agccagcaga aacccaccct acgacactgc     1260

agggagcaat aaggagagaa cccaccagct caccattgta ctcttacaca acagatggga     1320

atgacaccgt gacagagtct tcagatggcc tttggaataa caatcaaact caactgttcc     1380

tagaacatag tctactgacg gccaatacca ctaaaggaat ctatgctgga gtctgtattt     1440

ctgtcttggt gcttcttgct cttttgggtg tcatcattgc caaaaagtat ttcttcaaaa     1500

aggaggttca acaactaagt gtttcattta gcagccttca aattaaagct ttgcaaaatg     1560

cagttgaaaa ggaagtccaa gcagaagaca atatctacat tgagaatagt ctttatgcca     1620

cggactaaga cccagtggtg ctctttgaga gtttacgccc atgagtgcag aagactgaac     1680

agacatcagc acatcagacg tcttttagac cccaagacaa tttttctgtt tcagtttcat     1740

ctggcattcc aacatgtcag tgatactggg tagagtaact ctctcactcc aaactgtgta     1800

tagtcaacct catcattaat gtagtcctaa ttttttatgc t                         1841


<210>  140
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  140

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  141
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  141
gatctaaggc caccctctcg gggagggagt tggggaagct gggttggctg ggttggtagc       60

tcctacctac tgtgtggcaa gaaggtatgg gtcatgaaca gaaccaagga gctgcgctgc      120

tacagatgtt accacttctg tggctgctac cccactcctg ggccgtccct gaagctccta      180

ctccaatgtg gccagatgac ctgcaaaacc acacattcct gcacacagtg tactgccagg      240

atgggagtcc cagtgtggga ctctctgagg cctacgacga ggaccagctt ttcttcttcg      300

acttttccca gaacactcgg gtgcctcgcc tgcccgaatt tgctgactgg gctcaggaac      360

agggagatgc tcctgccatt ttatttgaca aagagttctg cgagtggatg atccagcaaa      420

tagggccaaa acttgatggg aaaatcccgg tgtccagagg gtttcctatc gctgaagtgt      480

tcacgctgaa gcccctggag tttggcaagc ccaacacttt ggtctgtttt gtcagtaatc      540

tcttcccacc catgctgaca gtgaactggc agcatcattc cgtccctgtg gaaggatttg      600

ggcctacttt tgtctcagct gtcgatggac tcagcttcca ggccttttct tacttaaact      660

tcacaccaga accttctgac attttctcct gcattgtgac tcacgaaatt gaccgctaca      720

cagcaattgc ctattgggta ccccggaacg cactgccctc agatctgctg gagaatgtgc      780

tgtgtggcgt ggcctttggc ctgggtgtgc tgggcatcat cgtgggcatt gttctcatca      840

tctacttccg gaagccttgc tcaggtgact gattcttcca gaccagagtt tgatgccagc      900

agcttcggcc atccaaacag aggatgctca gatttctcac atcctgccca ggatctcctc      960

ttagggtaga agtctctggg acatccctgg ggtgtgtgtg tagatttccc acctggggac     1020

tctgctgtcc ctgggcttgc atcccaggga tcccagagtg gcctgcctat cacaaccaca     1080

tcccttcccc ccacaaggca ataaatctca tttctttata tc                        1122


<210>  142
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  143
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  143
agttctcgct ccgcccccca cttcttgctc gttccctccc atccccccaa gccagtagct       60

gtgctgcgca gctccctaag cggttgtcac cgctggagac ggttgggaga accgttgtgg      120

cgagcgctac acgaggcaaa cgacttctcc cttctttgaa ctggaccccg cgagcaccag      180

agtcggcgta actatcgcct gacaggcatt taaatcaaac ggtattgaga tggattgggt      240

tatgaaacat aatggtccaa atgacgctag tgatgggaca gtacgacttc gtggactacc      300

atttggttgc agcaaagagg aaatagttca gttctttcaa gggttggaaa tcgtgccaaa      360

tgggataaca ttgacgatgg actaccaggg gagaagcaca ggggaggcct tcgtgcagtt      420

tgcttcaaag gagatagcag aaaatgctct ggggaaacac aaggaaagaa tagggcacag      480

gtatattgag atcttcagaa gtagcaggag tgaaatcaaa ggattttatg atccaccaag      540

aagattgctg ggacagcgac cgggaccata tgatagacca ataggaggaa gagggggtta      600

ttatggagct gggcgtggaa gtatgtatga cagaatgcga cgaggaggtg atggatatga      660

tggtggttat ggaggttttg atgactatgg tggctataat aattacggct atgggaatga      720

tggctttgat gacagaatga gagatggaag aggtatggga ggacatggct atggtggagc      780

tggtgatgca agttcaggtt ttcatggtgg tcatttcgta catatgagag ggttgccttt      840

tcgtgcaact gaaaatgaca ttgctaattt cttctcacca ctaaatccaa tacgagttca      900

tattgatatt ggagctgatg gcagagccac aggagaagca gatgtagagt ttgtgacaca      960

tgaagatgca gtagctgcca tgtctaaaga taaaaataac atgcaacatc gatatattga     1020

actcttcttg aattctactc ctggaggcgg ctctggcatg ggaggttctg gaatgggagg     1080

ctacggaaga gatggaatgg ataatcaggg aggctatgga tcagttggaa gaatgggaat     1140

ggggaacaat tacagtggag gatatggtac tcctgatggt ttgggtggtt atggccgtgg     1200

tggtggaggc agtggaggtt actatgggca aggcggcatg agtggaggtg gatggcgtgg     1260

gatgtactga aagcaaaaac accaacatac aagtcttgac aacagcatct ggtctactag     1320

actttcttac agatttaatt tcttttgtat tttaagaact ttataatgac tgaaggaatg     1380

tgttttcaaa atattatttg gtaaagcaac agattgtgat gggaaaatgt tttctgtagg     1440

tttatttgtt gcatactttg acttaaaaat aaatttttat attcaaacca ctgatgttga     1500

tactttttat atactagtta ctcctaaaga tgtgctgcct tcataagatt tgggttgatg     1560

tattttacta ttagttctac aagaagtagt gtggtgtaat tttagaggat aatggttcac     1620

ctctgcgtaa actgcaagtc ttaagcagac atctggaata gagcttgaca aataattagt     1680

gtaacttttt tctttagttc ctcctggaca acactgtaaa tataaagcct aaagatgaag     1740

tggcttcagg agtataaatt cagctaatta tttctatatt attatttttc aaatgtcatt     1800

tatcaggcat agctctgaaa cattgatgat ctaagaggta ttgatttctg aatattcata     1860

attgtgttac ctgggtatga gagtgttgga agctgaattc tagccctaga ttttggagta     1920

aaaccccttc agcacttgac cgaaatacca aaaatgtctc caaaaaattg atagttgcag     1980

gttatcgcaa gatgtcttag agtagggtta aggttctcag tgacacaaga attcagtatt     2040

aagtacatag gtatttacta tggagtataa ttctcacaat tgtattttca gttttctgcc     2100

caatagagtt taaataactg tataaatgat gactttaaaa aaatgtaagc aacaagtcca     2160

tgtcatagtc aataaaaaca atcctgcagt tgggttttgt atctgatccc tgcttggagt     2220

tttagtttaa agaatctata tgtagcaagg aaaaggtgct ttttaatttt aatccctttg     2280

atcaatatgg cttttttcca aattggctaa tggatcaaaa tgaaacctgt tgatgtgaat     2340

tcagttattg aacttgttac ttgtttttgc cagaaatgtt attaataaat gtcattgtgg     2400

gagataatag taaaaaaaaa aaaaaaa                                         2427


<210>  144
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly 
1               5                   10                  15      


Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile 
            20                  25                  30          


Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu 
        35                  40                  45              


Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe 
    50                  55                  60                  


Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg 
65                  70                  75                  80  


Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile 
                85                  90                  95      


Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly 
            100                 105                 110         


Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly 
        115                 120                 125             


Arg Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp 
    130                 135                 140                 


Gly Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly 
145                 150                 155                 160 


Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met 
                165                 170                 175     


Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His 
            180                 185                 190         


Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu 
        195                 200                 205             


Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His 
    210                 215                 220                 


Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu 
225                 230                 235                 240 


Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn 
                245                 250                 255     


Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly 
            260                 265                 270         


Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp 
        275                 280                 285             


Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met 
    290                 295                 300                 


Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly 
305                 310                 315                 320 


Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly 
                325                 330                 335     


Met Ser Gly Gly Gly Trp Arg Gly Met Tyr 
            340                 345     


<210>  145
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  145
agttctcgct ccgcccccca cttcttgctc gttccctccc atccccccaa gccagtagct       60

gtgctgcgca gctccctaag cggttgtcac cgctggagac ggttgggaga accgttgtgg      120

cgagcgctac acgaggcaaa cgacttctcc cttctttgaa ctggaccccg cgagcaccag      180

agtcggcgta actatcgcct gacaggcatt taaatcaaac ggtattgaga tggattgggt      240

tatgaaacat aatggtccaa atgacgctag tgatgggaca gtacgacttc gtggactacc      300

atttggttgc agcaaagagg aaatagttca gttctttcaa gggttggaaa tcgtgccaaa      360

tgggataaca ttgacgatgg actaccaggg gagaagcaca ggggaggcct tcgtgcagtt      420

tgcttcaaag gagatagcag aaaatgctct ggggaaacac aaggaaagaa tagggcacag      480

gtatattgag atcttcagaa gtagcaggag tgaaatcaaa ggattttatg atccaccaag      540

aagattgctg ggacagcgac cgggaccata tgatagacca ataggaggaa gagggggtta      600

ttatggagct gggcgtggaa gttatggagg ttttgatgac tatggtggct ataataatta      660

cggctatggg aatgatggct ttgatgacag aatgagagat ggaagaggta tgggaggaca      720

tggctatggt ggagctggtg atgcaagttc aggttttcat ggtggtcatt tcgtacatat      780

gagagggttg ccttttcgtg caactgaaaa tgacattgct aatttcttct caccactaaa      840

tccaatacga gttcatattg atattggagc tgatggcaga gccacaggag aagcagatgt      900

agagtttgtg acacatgaag atgcagtagc tgccatgtct aaagataaaa ataacatgca      960

acatcgatat attgaactct tcttgaattc tactcctgga ggcggctctg gcatgggagg     1020

ttctggaatg ggaggctacg gaagagatgg aatggataat cagggaggct atggatcagt     1080

tggaagaatg ggaatgggga acaattacag tggaggatat ggtactcctg atggtttggg     1140

tggttatggc cgtggtggtg gaggcagtgg aggttactat gggcaaggcg gcatgagtgg     1200

aggtggatgg cgtgggatgt actgaaagca aaaacaccaa catacaagtc ttgacaacag     1260

catctggtct actagacttt cttacagatt taatttcttt tgtattttaa gaactttata     1320

atgactgaag gaatgtgttt tcaaaatatt atttggtaaa gcaacagatt gtgatgggaa     1380

aatgttttct gtaggtttat ttgttgcata ctttgactta aaaataaatt tttatattca     1440

aaccactgat gttgatactt tttatatact agttactcct aaagatgtgc tgccttcata     1500

agatttgggt tgatgtattt tactattagt tctacaagaa gtagtgtggt gtaattttag     1560

aggataatgg ttcacctctg cgtaaactgc aagtcttaag cagacatctg gaatagagct     1620

tgacaaataa ttagtgtaac ttttttcttt agttcctcct ggacaacact gtaaatataa     1680

agcctaaaga tgaagtggct tcaggagtat aaattcagct aattatttct atattattat     1740

ttttcaaatg tcatttatca ggcatagctc tgaaacattg atgatctaag aggtattgat     1800

ttctgaatat tcataattgt gttacctggg tatgagagtg ttggaagctg aattctagcc     1860

ctagattttg gagtaaaacc ccttcagcac ttgaccgaaa taccaaaaat gtctccaaaa     1920

aattgatagt tgcaggttat cgcaagatgt cttagagtag ggttaaggtt ctcagtgaca     1980

caagaattca gtattaagta cataggtatt tactatggag tataattctc acaattgtat     2040

tttcagtttt ctgcccaata gagtttaaat aactgtataa atgatgactt taaaaaaatg     2100

taagcaacaa gtccatgtca tagtcaataa aaacaatcct gcagttgggt tttgtatctg     2160

atccctgctt ggagttttag tttaaagaat ctatatgtag caaggaaaag gtgcttttta     2220

attttaatcc ctttgatcaa tatggctttt ttccaaattg gctaatggat caaaatgaaa     2280

cctgttgatg tgaattcagt tattgaactt gttacttgtt tttgccagaa atgttattaa     2340

taaatgtcat tgtgggagat aatagtaaaa aaaaaaaaaa aa                        2382


<210>  146
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly 
1               5                   10                  15      


Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile 
            20                  25                  30          


Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu 
        35                  40                  45              


Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe 
    50                  55                  60                  


Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg 
65                  70                  75                  80  


Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile 
                85                  90                  95      


Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly 
            100                 105                 110         


Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly 
        115                 120                 125             


Arg Gly Ser Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr 
    130                 135                 140                 


Gly Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly 
145                 150                 155                 160 


Met Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe 
                165                 170                 175     


His Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr 
            180                 185                 190         


Glu Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val 
        195                 200                 205             


His Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val 
    210                 215                 220                 


Glu Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys 
225                 230                 235                 240 


Asn Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro 
                245                 250                 255     


Gly Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg 
            260                 265                 270         


Asp Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly 
        275                 280                 285             


Met Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly 
    290                 295                 300                 


Gly Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly 
305                 310                 315                 320 


Gly Met Ser Gly Gly Gly Trp Arg Gly Met Tyr 
                325                 330     


<210>  147
<211>  2995
<212>  DNA
<213>  Homo sapiens

<400>  147
ccctagccgc ccctcccccc agctagtgag tgcgcgaacg agaaaggagg agggcgctcc       60

aggcgacagc actgcagacg ccattatcct ctgtttctct gctgcaccga cctcgacgtc      120

ttgcctgtgt cccacttgtt cgcggcctat aggctactgc agcactgggg tgtcagttgt      180

tggtccgacc cagaacgctt cagttctgct ctgcaaggat atataataac tgattggtgt      240

gcccgtttaa taaaagaata tggaaactga acagccagaa gaaaccttcc ctaacactga      300

aaccaatggt gaatttggta aacgccctgc agaagatatg gaagaggaac aagcatttaa      360

aagatctaga aacactgatg agatggttga attacgcatt ctgcttcaga gcaagaatgc      420

tggggcagtg attggaaaag gaggcaagaa tattaaggct ctccgtacag actacaatgc      480

cagtgtttca gtcccagaca gcagtggccc cgagcgcata ttgagtatca gtgctgatat      540

tgaaacaatt ggagaaattc tgaagaaaat catccctacc ttggaagagg gcctgcagtt      600

gccatcaccc actgcaacca gccagctccc gctcgaatct gatgctgtgg aatgcttaaa      660

ttaccaacac tataaaggaa gtgactttga ctgcgagttg aggctgttga ttcatcagag      720

tctagcagga ggaattattg gggtcaaagg tgctaaaatc aaagaacttc gagagaacac      780

tcaaaccacc atcaagcttt tccaggaatg ctgtcctcat tccactgaca gagttgttct      840

tattggagga aaacccgata gggttgtaga gtgcataaag atcatccttg atcttatatc      900

tgagtctccc atcaaaggac gtgcacagcc ttatgatccc aatttttacg atgaaaccta      960

tgattatggt ggttttacaa tgatgtttga tgaccgtcgc ggacgcccag tgggatttcc     1020

catgcgggga agaggtggtt ttgacagaat gcctcctggt cggggtgggc gtcccatgcc     1080

tccatctaga agagattatg atgatatgag ccctcgtcga ggaccacctc cccctcctcc     1140

cggacgaggc ggccggggtg gtagcagagc tcggaatctt cctcttcctc caccaccacc     1200

acctagaggg ggagacctca tggcctatga cagaagaggg agacctggag accgttacga     1260

cggcatggtt ggtttcagtg ctgatgaaac ttgggactct gcaatagata catggagccc     1320

atcagaatgg cagatggctt atgaaccaca gggtggctcc ggatatgatt attcctatgc     1380

agggggtcgt ggctcatatg gtgatcttgg tggacctatt attactacac aagtaactat     1440

tcccaaagat ttggctggat ctattattgg caaaggtggt cagcggatta aacaaatccg     1500

tcatgagtcg ggagcttcga tcaaaattga tgagccttta gaaggatccg aagatcggat     1560

cattaccatt acaggaacac aggaccagat acagaatgca cagtatttgc tgcagaacag     1620

tgtgaagcag tatgcagatg ttgaaggatt ctaatgcaag atattttttc ttttttatag     1680

tgtgaagcag tattctggaa agtttttcta agactagtga agaactgaag gagtcctgca     1740

tctttttttt tttatctgct tctgtttaaa aagccaacat tcctctgctt cataggtgtt     1800

ctgcatttga ggtgtagtga aatctttgct gttcaccaga tgtaatgttt tagttcctta     1860

caaacagggt tggggggggg aagggcgtgc aaaaactaac attgaaattt tgaaacagca     1920

gcagagtgag tggattttat ttttcgttat tgttggtggt ttaaaaaatt ccccccatgt     1980

aattattgtg aacaccttgc tttgtggtca ctgtaacatt tggggggtgg gacagggagg     2040

aaaagtaaca atagtccaca tgtccctggc atctgttcag agcagtgtgc agaatgtaat     2100

gctcttttgt aagaaacgtt ttatgatttt taaaataaat ttagtgaacc tatttttggt     2160

ggtcattttt tttttaagac agtcatttta aaatggtggc tgaatttccc aacccacccc     2220

caaactaaac actaagttta attttcagct cctctgttgg acatataagt gcatctcttg     2280

ttggacatag gcaaaataac ttggcaaact tagttctggt gatttcttga tggtttggaa     2340

gtctattgct gggaagaaat tccatcatac atattcatgc ttataataag ctggggattt     2400

tttgtttgtt tttgcaaatg cttgccccta cttttcaaca attttctatg ttagttgtga     2460

agaactaagg tggggagcag tactacaagt tgagtaatgg tatgagtata taccagaatt     2520

ctgattggca gcaagtttta ttaatcagaa taacacttgg ttatggaagt gactaatgct     2580

gaaaaaattg attattttta ttagataatt tctcacctat agacttaaac tgtcaatttg     2640

ctctagtgtc ttattagtta aactttgtaa aatatatata tacttgtttt tccattgtat     2700

gcaaattgaa agaaaaagat gtaccatttc tctgttgtat gttggattat gtaggaaatg     2760

tttgtgtaca attcaaaaaa aaaaaagatg aaaaaagttc ctgtggatgt tttgtgtagt     2820

atcttggcat ttgtattgat agttaaaatt cacttccaaa taaataaaac acccatgatg     2880

ctagatttga tgtgtgcccg atttgaacaa gggttgattg acacctgtaa aatttgttga     2940

aacgttcctc ttaaaaggaa atatagtaat cttatgtaaa aaaaaaaaaa aaaaa          2995


<210>  148
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ala Asp Val Glu Gly Phe 
    450                 455                 460                 


<210>  149
<211>  2935
<212>  DNA
<213>  Homo sapiens

<400>  149
ccctagccgc ccctcccccc agctagtgag tgcgcgaacg agaaaggagg agggcgctcc       60

aggcgacagc actgcagacg ccattatcct ctgtttctct gctgcaccga cctcgacgtc      120

ttgcctgtgt cccacttgtt cgcggcctat aggctactgc agcactgggg tgtcagttgt      180

tggtccgacc cagaacgctt cagttctgct ctgcaaggat atataataac tgattggtgt      240

gcccgtttaa taaaagaata tggaaactga acagccagaa gaaaccttcc ctaacactga      300

aaccaatggt gaatttggta aacgccctgc agaagatatg gaagaggaac aagcatttaa      360

aagatctaga aacactgatg agatggttga attacgcatt ctgcttcaga gcaagaatgc      420

tggggcagtg attggaaaag gaggcaagaa tattaaggct ctccgtacag actacaatgc      480

cagtgtttca gtcccagaca gcagtggccc cgagcgcata ttgagtatca gtgctgatat      540

tgaaacaatt ggagaaattc tgaagaaaat catccctacc ttggaagagg gcctgcagtt      600

gccatcaccc actgcaacca gccagctccc gctcgaatct gatgctgtgg aatgcttaaa      660

ttaccaacac tataaaggaa gtgactttga ctgcgagttg aggctgttga ttcatcagag      720

tctagcagga ggaattattg gggtcaaagg tgctaaaatc aaagaacttc gagagaacac      780

tcaaaccacc atcaagcttt tccaggaatg ctgtcctcat tccactgaca gagttgttct      840

tattggagga aaacccgata gggttgtaga gtgcataaag atcatccttg atcttatatc      900

tgagtctccc atcaaaggac gtgcacagcc ttatgatccc aatttttacg atgaaaccta      960

tgattatggt ggttttacaa tgatgtttga tgaccgtcgc ggacgcccag tgggatttcc     1020

catgcgggga agaggtggtt ttgacagaat gcctcctggt cggggtgggc gtcccatgcc     1080

tccatctaga agagattatg atgatatgag ccctcgtcga ggaccacctc cccctcctcc     1140

cggacgaggc ggccggggtg gtagcagagc tcggaatctt cctcttcctc caccaccacc     1200

acctagaggg ggagacctca tggcctatga cagaagaggg agacctggag accgttacga     1260

cggcatggtt ggtttcagtg ctgatgaaac ttgggactct gcaatagata catggagccc     1320

atcagaatgg cagatggctt atgaaccaca gggtggctcc ggatatgatt attcctatgc     1380

agggggtcgt ggctcatatg gtgatcttgg tggacctatt attactacac aagtaactat     1440

tcccaaagat ttggctggat ctattattgg caaaggtggt cagcggatta aacaaatccg     1500

tcatgagtcg ggagcttcga tcaaaattga tgagccttta gaaggatccg aagatcggat     1560

cattaccatt acaggaacac aggaccagat acagaatgca cagtatttgc tgcagaacag     1620

tgtgaagcag tattctggaa agtttttcta agactagtga agaactgaag gagtcctgca     1680

tctttttttt tttatctgct tctgtttaaa aagccaacat tcctctgctt cataggtgtt     1740

ctgcatttga ggtgtagtga aatctttgct gttcaccaga tgtaatgttt tagttcctta     1800

caaacagggt tggggggggg aagggcgtgc aaaaactaac attgaaattt tgaaacagca     1860

gcagagtgag tggattttat ttttcgttat tgttggtggt ttaaaaaatt ccccccatgt     1920

aattattgtg aacaccttgc tttgtggtca ctgtaacatt tggggggtgg gacagggagg     1980

aaaagtaaca atagtccaca tgtccctggc atctgttcag agcagtgtgc agaatgtaat     2040

gctcttttgt aagaaacgtt ttatgatttt taaaataaat ttagtgaacc tatttttggt     2100

ggtcattttt tttttaagac agtcatttta aaatggtggc tgaatttccc aacccacccc     2160

caaactaaac actaagttta attttcagct cctctgttgg acatataagt gcatctcttg     2220

ttggacatag gcaaaataac ttggcaaact tagttctggt gatttcttga tggtttggaa     2280

gtctattgct gggaagaaat tccatcatac atattcatgc ttataataag ctggggattt     2340

tttgtttgtt tttgcaaatg cttgccccta cttttcaaca attttctatg ttagttgtga     2400

agaactaagg tggggagcag tactacaagt tgagtaatgg tatgagtata taccagaatt     2460

ctgattggca gcaagtttta ttaatcagaa taacacttgg ttatggaagt gactaatgct     2520

gaaaaaattg attattttta ttagataatt tctcacctat agacttaaac tgtcaatttg     2580

ctctagtgtc ttattagtta aactttgtaa aatatatata tacttgtttt tccattgtat     2640

gcaaattgaa agaaaaagat gtaccatttc tctgttgtat gttggattat gtaggaaatg     2700

tttgtgtaca attcaaaaaa aaaaaagatg aaaaaagttc ctgtggatgt tttgtgtagt     2760

atcttggcat ttgtattgat agttaaaatt cacttccaaa taaataaaac acccatgatg     2820

ctagatttga tgtgtgcccg atttgaacaa gggttgattg acacctgtaa aatttgttga     2880

aacgttcctc ttaaaaggaa atatagtaat cttatgtaaa aaaaaaaaaa aaaaa          2935


<210>  150
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  151
<211>  2960
<212>  DNA
<213>  Homo sapiens

<400>  151
tagggcgcga cggcggggag gacgcgagaa ggcgggggag gggagcctgc gctcgttttc       60

tgtctagctc cgaccggctg aggcggcgcg gcagcggagg gacggcagtc tcgcgcggct      120

actgcagcac tggggtgtca gttgttggtc cgacccagaa cgcttcagtt ctgctctgca      180

aggatatata ataactgatt ggtgtgcccg tttaataaaa gaatatggaa actgaacagc      240

cagaagaaac cttccctaac actgaaacca atggtgaatt tggtaaacgc cctgcagaag      300

atatggaaga ggaacaagca tttaaaagat ctagaaacac tgatgagatg gttgaattac      360

gcattctgct tcagagcaag aatgctgggg cagtgattgg aaaaggaggc aagaatatta      420

aggctctccg tacagactac aatgccagtg tttcagtccc agacagcagt ggccccgagc      480

gcatattgag tatcagtgct gatattgaaa caattggaga aattctgaag aaaatcatcc      540

ctaccttgga agagggcctg cagttgccat cacccactgc aaccagccag ctcccgctcg      600

aatctgatgc tgtggaatgc ttaaattacc aacactataa aggaagtgac tttgactgcg      660

agttgaggct gttgattcat cagagtctag caggaggaat tattggggtc aaaggtgcta      720

aaatcaaaga acttcgagag aacactcaaa ccaccatcaa gcttttccag gaatgctgtc      780

ctcattccac tgacagagtt gttcttattg gaggaaaacc cgatagggtt gtagagtgca      840

taaagatcat ccttgatctt atatctgagt ctcccatcaa aggacgtgca cagccttatg      900

atcccaattt ttacgatgaa acctatgatt atggtggttt tacaatgatg tttgatgacc      960

gtcgcggacg cccagtggga tttcccatgc ggggaagagg tggttttgac agaatgcctc     1020

ctggtcgggg tgggcgtccc atgcctccat ctagaagaga ttatgatgat atgagccctc     1080

gtcgaggacc acctccccct cctcccggac gaggcggccg gggtggtagc agagctcgga     1140

atcttcctct tcctccacca ccaccaccta gagggggaga cctcatggcc tatgacagaa     1200

gagggagacc tggagaccgt tacgacggca tggttggttt cagtgctgat gaaacttggg     1260

actctgcaat agatacatgg agcccatcag aatggcagat ggcttatgaa ccacagggtg     1320

gctccggata tgattattcc tatgcagggg gtcgtggctc atatggtgat cttggtggac     1380

ctattattac tacacaagta actattccca aagatttggc tggatctatt attggcaaag     1440

gtggtcagcg gattaaacaa atccgtcatg agtcgggagc ttcgatcaaa attgatgagc     1500

ctttagaagg atccgaagat cggatcatta ccattacagg aacacaggac cagatacaga     1560

atgcacagta tttgctgcag aacagtgtga agcagtatgc agatgttgaa ggattctaat     1620

gcaagatatt ttttcttttt tatagtgtga agcagtattc tggaaagttt ttctaagact     1680

agtgaagaac tgaaggagtc ctgcatcttt ttttttttat ctgcttctgt ttaaaaagcc     1740

aacattcctc tgcttcatag gtgttctgca tttgaggtgt agtgaaatct ttgctgttca     1800

ccagatgtaa tgttttagtt ccttacaaac agggttgggg gggggaaggg cgtgcaaaaa     1860

ctaacattga aattttgaaa cagcagcaga gtgagtggat tttatttttc gttattgttg     1920

gtggtttaaa aaattccccc catgtaatta ttgtgaacac cttgctttgt ggtcactgta     1980

acatttgggg ggtgggacag ggaggaaaag taacaatagt ccacatgtcc ctggcatctg     2040

ttcagagcag tgtgcagaat gtaatgctct tttgtaagaa acgttttatg atttttaaaa     2100

taaatttagt gaacctattt ttggtggtca tttttttttt aagacagtca ttttaaaatg     2160

gtggctgaat ttcccaaccc acccccaaac taaacactaa gtttaatttt cagctcctct     2220

gttggacata taagtgcatc tcttgttgga cataggcaaa ataacttggc aaacttagtt     2280

ctggtgattt cttgatggtt tggaagtcta ttgctgggaa gaaattccat catacatatt     2340

catgcttata ataagctggg gattttttgt ttgtttttgc aaatgcttgc ccctactttt     2400

caacaatttt ctatgttagt tgtgaagaac taaggtgggg agcagtacta caagttgagt     2460

aatggtatga gtatatacca gaattctgat tggcagcaag ttttattaat cagaataaca     2520

cttggttatg gaagtgacta atgctgaaaa aattgattat ttttattaga taatttctca     2580

cctatagact taaactgtca atttgctcta gtgtcttatt agttaaactt tgtaaaatat     2640

atatatactt gtttttccat tgtatgcaaa ttgaaagaaa aagatgtacc atttctctgt     2700

tgtatgttgg attatgtagg aaatgtttgt gtacaattca aaaaaaaaaa agatgaaaaa     2760

agttcctgtg gatgttttgt gtagtatctt ggcatttgta ttgatagtta aaattcactt     2820

ccaaataaat aaaacaccca tgatgctaga tttgatgtgt gcccgatttg aacaagggtt     2880

gattgacacc tgtaaaattt gttgaaacgt tcctcttaaa aggaaatata gtaatcttat     2940

gtaaaaaaaa aaaaaaaaaa                                                 2960


<210>  152
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ala Asp Val Glu Gly Phe 
    450                 455                 460                 


<210>  153
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  153
atgtctctca taatcaatac cttctattcc aacaaggaga ttttccttca ggagttgatc       60

tctaatgctt ctgatgcctt agacaagatt cgctatgaga gcctgacaga cccttccaag      120

ttggacggtg gtaaagaact gaaaattgac atcatcccca accctcggga atgcatcctg      180

actttggtca acacaggcat tggcatgacc aaggctgatc tcataaataa tttgggagcc      240

attgccaagt ctggtactga agcatttatg gaggcttttc agtcttgtgc agaaatctcc      300

atgattgggc aatttggtgt tggcttttat tctgcctacc tggtggcaga gaaagtagcc      360

atcacaaagc acaatgacga agaacagtat tcctgggtat cttctgctgg gagttccttc      420

actttacatg ttgaccatgg tgagcccatt gacagggata ccaaagtgat ccttcacctt      480

aaagaagatc agacagagta cttagaagag aggtgggtca aagaagtagt gaagaagcac      540

cctcagttca taggctgtct tatcgccgtt tatttggaga aggaaccaga gaaggaaatc      600

agtgatgatg aggaagagaa aggtgagaaa gaagaggaag ataaagatga taaagaaaag      660

cccaagactg aagatgtggg ttccgatgag gaggatgaca ctgataagaa taataagaag      720

aaaacaaaga agatcaagga gaaatacact gatcgggaag aactaaacca gaccaagccg      780

atttggacca gaaaccctga tgacatcacc caggaagagt gtggagaatt ctacaagagc      840

ctcaccagtg cctgggaaga ccacttggca gtcaagcaat tccctgtaga agaacaagag      900

gaaaatgaac aactctgtgt ccatcatgtg tggatcatgg acagctttga tgatttgatg      960

ccagagtatg tcggctttgt ccgtgaagac aaggagaata acaagaaatt agatgaggta     1020

ttctctaaaa tctcgtggct tggaatccat gaggactcta ttaactggcg acacctgtct     1080

gaactgctgt ggtctcacac cttccagtct ggagatgaga tgacatctct gtcagagtat     1140

gtgtcttgca tgaaggaggc acagaagtcc atctgtgaca tcattggtga gtgcaaagag     1200

caggtagcca actctgcttt tgtggagcaa gagtggaaga agggcttcga ggtaatatat     1260

atgagtgagc ccattgatga gtactgtgtg cagcagctca aggaatttga tgggaagagc     1320

ctgctgtcag ttaccaagga gggtctggag ctacctgagg atgaggagga gaagaagata     1380

atggaggaga gcaacgtaaa gtttgagaac ctctgcaggc tcatgaaaga aatcttagat     1440

aagaaggttg agcgggtgac aatctccagt aggcttgtgt cttcaccctg ccgcattgtg     1500

accagcacct acagctag                                                   1518


<210>  154
<211>  3549
<212>  DNA
<213>  Homo sapiens

<400>  154
ggagcgcgtg cgccctctta ctcggctccc cttggtttcc tggggtcctg ccccttcaag       60

ctggggcggg agcggaggac cccgctctca ggggttgccg gaccatgcgt tgggggctgc      120

gccctcgcgg gccgggcgcg gccgccctgg ccactgcccg aagtttgtgg gggacgcccc      180

gccttccctg cagcccggga tggcaagggg cgacgaagag gcttctggtg cggtcggtct      240

ccggggccag taaccaccag ccgaactcga atagtggcag ataccgggac acggtgctgc      300

tgccgcagac gagcttcccc atgaagctgc tgggccgcca gcagccggac acggagctgg      360

agatccagca gaaatgtgga ttttcagaac tttattcatg gcaaagagaa agaaaagtaa      420

agacagaatt ttgccttcat gatggacctc cttatgcaaa cggtgaccct catgttggac      480

atgctttaaa taagattttg aaagacatag ccaatcgatt ccatatgatg aatggctcca      540

aaatacattt tgtgcccggc tgggattgtc atgggttgcc cattgaaata aaagtattat      600

cagaacttgg tagagaagct cagaatcttt cagctatgga aattagaaag aaagctagat      660

catttgctaa agcagccatt gagaaacaga aatcagcatt tattcgttgg ggaataatgg      720

cagattggaa taattgctac tatacatttg atgggaagta tgaagccaaa cagttgagaa      780

ctttttacca aatgtatgat aagggcttgg tttatcgatc ttacaaacct gtgttttggt      840

ctccgtcatc taggactgca ttggctgaag cagaacttga atataatcct gagcatgtca      900

gtcgttcaat atatgtaaaa tttcctctct taaagccttc tccaaaattg gcatctctta      960

tagatggttc atctcctgtt agtattttgg tctggaccac acaaccttgg acgattccag     1020

ccaatgaagc tgtttgctat atgcctgaat caaagtatgc tgttgtgaaa tgttctaagt     1080

ctggagacct ctacgtactg gcggcagata aagtagcatc tgttgcttct actttggaaa     1140

caacatttga gactatttca acactttcag gtgtagattt ggaaaatggt acttgcagtc     1200

atccattaat tcctgataaa gcctctcctc ttttacctgc aaatcatgtg accatggcaa     1260

aaggaacggg attggttcac acagccccag ctcatggtat ggaagactac ggtgtagcgt     1320

ctcagcacaa cctgcccatg gattgtctag tggacgaaga tggagttttc acagatgttg     1380

caggtcctga acttcaaaac aaggctgtcc ttgaagaggg aactgatgtg gttataaaga     1440

tgcttcagac tgcaaagaat ttgttgaaag aggagaaatt ggtgcatagc tatccgtatg     1500

actggaggac caagaaacct gtggttattc gtgccagcaa gcagtggttt ataaacatca     1560

cggatattaa gactgcagcc aaggaattgt taaaaaaggt gaaatttatt cctggatcag     1620

cactgaatgg catggttgaa atgatggaca ggcggccata ttggtgtata tcaaggcaaa     1680

gagtttgggg tgttccaatt cctgtgtttc atcataagac caaggatgaa tacttgatca     1740

acagccaaac cactgagcat attgttaaac tagtggaaca acacggcagt gatatctggt     1800

ggactcttcc ccctgaacaa cttcttccaa aagaagtctt atctgaggtt ggtggccctg     1860

atgccttgga atatgtgcca ggtcaggata ttttggacat ctggtttgat agcggaactt     1920

catggtctta tgttcttcca ggtcctgacc aaagagcaga tttgtacttg gaaggaaaag     1980

accagctcgg gggttggttt cagtcatcct tattaacaag tgtggcagca aggaagagag     2040

caccttataa gacagtgatt gttcatggat ttacccttgg agaaaaggga gaaaagatgt     2100

ccaagtctct tgggaatgtc attcatcctg atgttgtcgt taatggagga caagatcaaa     2160

gcaaagagcc tccgtatggt gctgatgtcc ttcgctggtg ggtagctgat tccaatgtct     2220

tcaccgaagt tgcaattggc ccatccgtgc tcaatgctgc cagagatgat attagcaagc     2280

ttaggaatac acttcgcttt cttttgggaa atgtggctga tttcaaccca gaaacagatt     2340

ccatccctgt aaacgatatg tatgtcatag accagtacat gctacactta ctgcaggatt     2400

tggcaaacaa gattaccgaa ttatacaaac aatatgattt tggaaaagtt gttcggctgt     2460

tacggacgtt ttataccaga gagctctcta acttttattt cagtataatc aaagataggc     2520

tctattgtga aaaggaaaat gaccccaaac gacgctcttg tcagactgca ttagttgaaa     2580

ttttggatgt aatagttcgt tcttttgctc ccattcttcc tcacctggct gaagaggtgt     2640

tccagcacat accttatatt aaagagccca agagtgtttt ccgtactggg tggattagta     2700

ctagttctat ctggaaaaag cccgggttgg aagaagctgt ggagagtgcg tgtgcaatgc     2760

gagactcatt tcttggaagc atccctggca aaaatgcagc tgagtacaag gttatcactg     2820

tgatagaacc tggactgctt tttgagataa tagagatgct gcagtctgaa gagacttcca     2880

gcacctctca gttgaatgaa ttaatgatgg cttctgagtc aactttactg gctcaggaac     2940

cacgagagat gactgcagat gtaatcgagc ttaaagggaa attcctcatc aacttagaag     3000

gtggtgatat tcgtgaagag tcttcctata aagtaattgt catgccgact acgaaagaaa     3060

aatgcccccg ttgttggaag tatacagcgg agtcttcaga tacactgtgt cctcgatgtg     3120

cagaagttgt cagtggaaaa tagtattaac agctcactcg agcaagaacc ctcctgacag     3180

tactggctag aagtttggat ggattattta caatatagga aagaaagcca agatttaggt     3240

aatgagtgga tgagtaaatg gtggaggatg ggagtcaaaa tcagaattat agaagaagta     3300

tttcctgtaa ctatagaaag aattatgtat atatacatgc agaaatatat atgtgtgtgt     3360

gtatctgtgg atggatatat gtatatctct tcctatatat atccatagtg gacttattca     3420

gaacatagat atgtattcag cttgtcttca aatacggcca agcagaaaat gttttatatt     3480

ttataaatca tcttttgact ctgtatttaa attctatgat actgaaaata aaggcattct     3540

ggaaaaata                                                             3549


<210>  155
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Arg Trp Gly Leu Arg Pro Arg Gly Pro Gly Ala Ala Ala Leu Ala 
1               5                   10                  15      


Thr Ala Arg Ser Leu Trp Gly Thr Pro Arg Leu Pro Cys Ser Pro Gly 
            20                  25                  30          


Trp Gln Gly Ala Thr Lys Arg Leu Leu Val Arg Ser Val Ser Gly Ala 
        35                  40                  45              


Ser Asn His Gln Pro Asn Ser Asn Ser Gly Arg Tyr Arg Asp Thr Val 
    50                  55                  60                  


Leu Leu Pro Gln Thr Ser Phe Pro Met Lys Leu Leu Gly Arg Gln Gln 
65                  70                  75                  80  


Pro Asp Thr Glu Leu Glu Ile Gln Gln Lys Cys Gly Phe Ser Glu Leu 
                85                  90                  95      


Tyr Ser Trp Gln Arg Glu Arg Lys Val Lys Thr Glu Phe Cys Leu His 
            100                 105                 110         


Asp Gly Pro Pro Tyr Ala Asn Gly Asp Pro His Val Gly His Ala Leu 
        115                 120                 125             


Asn Lys Ile Leu Lys Asp Ile Ala Asn Arg Phe His Met Met Asn Gly 
    130                 135                 140                 


Ser Lys Ile His Phe Val Pro Gly Trp Asp Cys His Gly Leu Pro Ile 
145                 150                 155                 160 


Glu Ile Lys Val Leu Ser Glu Leu Gly Arg Glu Ala Gln Asn Leu Ser 
                165                 170                 175     


Ala Met Glu Ile Arg Lys Lys Ala Arg Ser Phe Ala Lys Ala Ala Ile 
            180                 185                 190         


Glu Lys Gln Lys Ser Ala Phe Ile Arg Trp Gly Ile Met Ala Asp Trp 
        195                 200                 205             


Asn Asn Cys Tyr Tyr Thr Phe Asp Gly Lys Tyr Glu Ala Lys Gln Leu 
    210                 215                 220                 


Arg Thr Phe Tyr Gln Met Tyr Asp Lys Gly Leu Val Tyr Arg Ser Tyr 
225                 230                 235                 240 


Lys Pro Val Phe Trp Ser Pro Ser Ser Arg Thr Ala Leu Ala Glu Ala 
                245                 250                 255     


Glu Leu Glu Tyr Asn Pro Glu His Val Ser Arg Ser Ile Tyr Val Lys 
            260                 265                 270         


Phe Pro Leu Leu Lys Pro Ser Pro Lys Leu Ala Ser Leu Ile Asp Gly 
        275                 280                 285             


Ser Ser Pro Val Ser Ile Leu Val Trp Thr Thr Gln Pro Trp Thr Ile 
    290                 295                 300                 


Pro Ala Asn Glu Ala Val Cys Tyr Met Pro Glu Ser Lys Tyr Ala Val 
305                 310                 315                 320 


Val Lys Cys Ser Lys Ser Gly Asp Leu Tyr Val Leu Ala Ala Asp Lys 
                325                 330                 335     


Val Ala Ser Val Ala Ser Thr Leu Glu Thr Thr Phe Glu Thr Ile Ser 
            340                 345                 350         


Thr Leu Ser Gly Val Asp Leu Glu Asn Gly Thr Cys Ser His Pro Leu 
        355                 360                 365             


Ile Pro Asp Lys Ala Ser Pro Leu Leu Pro Ala Asn His Val Thr Met 
    370                 375                 380                 


Ala Lys Gly Thr Gly Leu Val His Thr Ala Pro Ala His Gly Met Glu 
385                 390                 395                 400 


Asp Tyr Gly Val Ala Ser Gln His Asn Leu Pro Met Asp Cys Leu Val 
                405                 410                 415     


Asp Glu Asp Gly Val Phe Thr Asp Val Ala Gly Pro Glu Leu Gln Asn 
            420                 425                 430         


Lys Ala Val Leu Glu Glu Gly Thr Asp Val Val Ile Lys Met Leu Gln 
        435                 440                 445             


Thr Ala Lys Asn Leu Leu Lys Glu Glu Lys Leu Val His Ser Tyr Pro 
    450                 455                 460                 


Tyr Asp Trp Arg Thr Lys Lys Pro Val Val Ile Arg Ala Ser Lys Gln 
465                 470                 475                 480 


Trp Phe Ile Asn Ile Thr Asp Ile Lys Thr Ala Ala Lys Glu Leu Leu 
                485                 490                 495     


Lys Lys Val Lys Phe Ile Pro Gly Ser Ala Leu Asn Gly Met Val Glu 
            500                 505                 510         


Met Met Asp Arg Arg Pro Tyr Trp Cys Ile Ser Arg Gln Arg Val Trp 
        515                 520                 525             


Gly Val Pro Ile Pro Val Phe His His Lys Thr Lys Asp Glu Tyr Leu 
    530                 535                 540                 


Ile Asn Ser Gln Thr Thr Glu His Ile Val Lys Leu Val Glu Gln His 
545                 550                 555                 560 


Gly Ser Asp Ile Trp Trp Thr Leu Pro Pro Glu Gln Leu Leu Pro Lys 
                565                 570                 575     


Glu Val Leu Ser Glu Val Gly Gly Pro Asp Ala Leu Glu Tyr Val Pro 
            580                 585                 590         


Gly Gln Asp Ile Leu Asp Ile Trp Phe Asp Ser Gly Thr Ser Trp Ser 
        595                 600                 605             


Tyr Val Leu Pro Gly Pro Asp Gln Arg Ala Asp Leu Tyr Leu Glu Gly 
    610                 615                 620                 


Lys Asp Gln Leu Gly Gly Trp Phe Gln Ser Ser Leu Leu Thr Ser Val 
625                 630                 635                 640 


Ala Ala Arg Lys Arg Ala Pro Tyr Lys Thr Val Ile Val His Gly Phe 
                645                 650                 655     


Thr Leu Gly Glu Lys Gly Glu Lys Met Ser Lys Ser Leu Gly Asn Val 
            660                 665                 670         


Ile His Pro Asp Val Val Val Asn Gly Gly Gln Asp Gln Ser Lys Glu 
        675                 680                 685             


Pro Pro Tyr Gly Ala Asp Val Leu Arg Trp Trp Val Ala Asp Ser Asn 
    690                 695                 700                 


Val Phe Thr Glu Val Ala Ile Gly Pro Ser Val Leu Asn Ala Ala Arg 
705                 710                 715                 720 


Asp Asp Ile Ser Lys Leu Arg Asn Thr Leu Arg Phe Leu Leu Gly Asn 
                725                 730                 735     


Val Ala Asp Phe Asn Pro Glu Thr Asp Ser Ile Pro Val Asn Asp Met 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Met Leu His Leu Leu Gln Asp Leu Ala Asn 
        755                 760                 765             


Lys Ile Thr Glu Leu Tyr Lys Gln Tyr Asp Phe Gly Lys Val Val Arg 
    770                 775                 780                 


Leu Leu Arg Thr Phe Tyr Thr Arg Glu Leu Ser Asn Phe Tyr Phe Ser 
785                 790                 795                 800 


Ile Ile Lys Asp Arg Leu Tyr Cys Glu Lys Glu Asn Asp Pro Lys Arg 
                805                 810                 815     


Arg Ser Cys Gln Thr Ala Leu Val Glu Ile Leu Asp Val Ile Val Arg 
            820                 825                 830         


Ser Phe Ala Pro Ile Leu Pro His Leu Ala Glu Glu Val Phe Gln His 
        835                 840                 845             


Ile Pro Tyr Ile Lys Glu Pro Lys Ser Val Phe Arg Thr Gly Trp Ile 
    850                 855                 860                 


Ser Thr Ser Ser Ile Trp Lys Lys Pro Gly Leu Glu Glu Ala Val Glu 
865                 870                 875                 880 


Ser Ala Cys Ala Met Arg Asp Ser Phe Leu Gly Ser Ile Pro Gly Lys 
                885                 890                 895     


Asn Ala Ala Glu Tyr Lys Val Ile Thr Val Ile Glu Pro Gly Leu Leu 
            900                 905                 910         


Phe Glu Ile Ile Glu Met Leu Gln Ser Glu Glu Thr Ser Ser Thr Ser 
        915                 920                 925             


Gln Leu Asn Glu Leu Met Met Ala Ser Glu Ser Thr Leu Leu Ala Gln 
    930                 935                 940                 


Glu Pro Arg Glu Met Thr Ala Asp Val Ile Glu Leu Lys Gly Lys Phe 
945                 950                 955                 960 


Leu Ile Asn Leu Glu Gly Gly Asp Ile Arg Glu Glu Ser Ser Tyr Lys 
                965                 970                 975     


Val Ile Val Met Pro Thr Thr Lys Glu Lys Cys Pro Arg Cys Trp Lys 
            980                 985                 990         


Tyr Thr Ala Glu Ser Ser Asp Thr  Leu Cys Pro Arg Cys  Ala Glu Val 
        995                 1000                 1005             


Val Ser  Gly Lys 
    1010         


<210>  156
<211>  1145
<212>  DNA
<213>  Homo sapiens

<400>  156
attctctccc cagcttgctg agccctttgc tcccctggcg actgcctgga cagtcagcaa       60

ggaattgtct cccagtgcat tttgccctcc tggctgccaa ctctggctgc taaagcggct      120

gccacctgct gcagtctaca cagcttcggg aagaggaaag gaacctcaga ccttccagat      180

cgcttcctct cgcaacaaac tatttgtcgc aggaataaag atggctgctg aaccagtaga      240

agacaattgc atcaactttg tggcaatgaa atttattgac aatacgcttt actttatagc      300

tgaagatgat gaaaacctgg aatcagatta ctttggcaag cttgaatcta aattatcagt      360

cataagaaat ttgaatgacc aagttctctt cattgaccaa ggaaatcggc ctctatttga      420

agatatgact gattctgact gtagagataa tgcaccccgg accatattta ttataagtat      480

gtataaagat agccagccta gaggtatggc tgtaactatc tctgtgaagt gtgagaaaat      540

ttcaactctc tcctgtgaga acaaaattat ttcctttaag gaaatgaatc ctcctgataa      600

catcaaggat acaaaaagtg acatcatatt ctttcagaga agtgtcccag gacatgataa      660

taagatgcaa tttgaatctt catcatacga aggatacttt ctagcttgtg aaaaagagag      720

agaccttttt aaactcattt tgaaaaaaga ggatgaattg ggggatagat ctataatgtt      780

cactgttcaa aacgaagact agctattaaa atttcatgcc gggcgcagtg gctcacgcct      840

gtaatcccag ccctttggga ggctgaggcg ggcagatcac cagaggtcag gtgttcaaga      900

ccagcctgac caacatggtg aaacctcatc tctactaaaa atacaaaaaa ttagctgagt      960

gtagtgacgc atgccctcaa tcccagctac tcaagaggct gaggcaggag aatcacttgc     1020

actccggagg tagaggttgt ggtgagccga gattgcacca ttgcgctcta gcctgggcaa     1080

caacagcaaa actccatctc aaaaaataaa ataaataaat aaacaaataa aaaattcata     1140

atgtg                                                                 1145


<210>  157
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  158
<211>  9071
<212>  DNA
<213>  Homo sapiens

<400>  158
actggggtgg cgcgctacct ctgcggagaa ggatctgaca gtgttccgga gccggggcga       60

gcagccaaaa ggcccgcgga gtcgcgctgg gccgccccgg cgcagctgaa ccgggggccg      120

cgcctgccag gccgacgggt ctggcccagc ctggcgccaa ggggttcgtg cgctgtggag      180

acgcggaggg tcgaggcggc gcggcctgag tgaaacccaa tggaaaaagc atgacattta      240

gaagtagaag acttagcttc aaatccctac tccttcactt actaattttg tgatttggaa      300

atatccgcgc aagatgttga cgttgcagac ttggctagtg caagccttgt ttattttcct      360

caccactgaa tctacaggtg aacttctaga tccatgtggt tatatcagtc ctgaatctcc      420

agttgtacaa cttcattcta atttcactgc agtttgtgtg ctaaaggaaa aatgtatgga      480

ttattttcat gtaaatgcta attacattgt ctggaaaaca aaccatttta ctattcctaa      540

ggagcaatat actatcataa acagaacagc atccagtgtc acctttacag atatagcttc      600

attaaatatt cagctcactt gcaacattct tacattcgga cagcttgaac agaatgttta      660

tggaatcaca ataatttcag gcttgcctcc agaaaaacct aaaaatttga gttgcattgt      720

gaacgagggg aagaaaatga ggtgtgagtg ggatggtgga agggaaacac acttggagac      780

aaacttcact ttaaaatctg aatgggcaac acacaagttt gctgattgca aagcaaaacg      840

tgacaccccc acctcatgca ctgttgatta ttctactgtg tattttgtca acattgaagt      900

ctgggtagaa gcagagaatg cccttgggaa ggttacatca gatcatatca attttgatcc      960

tgtatataaa gtgaagccca atccgccaca taatttatca gtgatcaact cagaggaact     1020

gtctagtatc ttaaaattga catggaccaa cccaagtatt aagagtgtta taatactaaa     1080

atataacatt caatatagga ccaaagatgc ctcaacttgg agccagattc ctcctgaaga     1140

cacagcatcc acccgatctt cattcactgt ccaagacctt aaacctttta cagaatatgt     1200

gtttaggatt cgctgtatga aggaagatgg taagggatac tggagtgact ggagtgaaga     1260

agcaagtggg atcacctatg aagatagacc atctaaagca ccaagtttct ggtataaaat     1320

agatccatcc catactcaag gctacagaac tgtacaactc gtgtggaaga cattgcctcc     1380

ttttgaagcc aatggaaaaa tcttggatta tgaagtgact ctcacaagat ggaaatcaca     1440

tttacaaaat tacacagtta atgccacaaa actgacagta aatctcacaa atgatcgcta     1500

tctagcaacc ctaacagtaa gaaatcttgt tggcaaatca gatgcagctg ttttaactat     1560

ccctgcctgt gactttcaag ctactcaccc tgtaatggat cttaaagcat tccccaaaga     1620

taacatgctt tgggtggaat ggactactcc aagggaatct gtaaagaaat atatacttga     1680

gtggtgtgtg ttatcagata aagcaccctg tatcacagac tggcaacaag aagatggtac     1740

cgtgcatcgc acctatttaa gagggaactt agcagagagc aaatgctatt tgataacagt     1800

tactccagta tatgctgatg gaccaggaag ccctgaatcc ataaaggcat accttaaaca     1860

agctccacct tccaaaggac ctactgttcg gacaaaaaaa gtagggaaaa acgaagctgt     1920

cttagagtgg gaccaacttc ctgttgatgt tcagaatgga tttatcagaa attatactat     1980

attttataga accatcattg gaaatgaaac tgctgtgaat gtggattctt cccacacaga     2040

atatacattg tcctctttga ctagtgacac attgtacatg gtacgaatgg cagcatacac     2100

agatgaaggt gggaaggatg gtccagaatt cacttttact accccaaagt ttgctcaagg     2160

agaaattgaa gccatagtcg tgcctgtttg cttagcattc ctattgacaa ctcttctggg     2220

agtgctgttc tgctttaata agcgagacct aattaaaaaa cacatctggc ctaatgttcc     2280

agatccttca aagagtcata ttgcccagtg gtcacctcac actcctccaa ggcacaattt     2340

taattcaaaa gatcaaatgt attcagatgg caatttcact gatgtaagtg ttgtggaaat     2400

agaagcaaat gacaaaaagc cttttccaga agatctgaaa tcattggacc tgttcaaaaa     2460

ggaaaaaatt aatactgaag gacacagcag tggtattggg gggtcttcat gcatgtcatc     2520

ttctaggcca agcatttcta gcagtgatga aaatgaatct tcacaaaaca cttcgagcac     2580

tgtccagtat tctaccgtgg tacacagtgg ctacagacac caagttccgt cagtccaagt     2640

cttctcaaga tccgagtcta cccagccctt gttagattca gaggagcggc cagaagatct     2700

acaattagta gatcatgtag atggcggtga tggtattttg cccaggcaac agtacttcaa     2760

acagaactgc agtcagcatg aatccagtcc agatatttca cattttgaaa ggtcaaagca     2820

agtttcatca gtcaatgagg aagattttgt tagacttaaa cagcagattt cagatcatat     2880

ttcacaatcc tgtggatctg ggcaaatgaa aatgtttcag gaagtttctg cagcagatgc     2940

ttttggtcca ggtactgagg gacaagtaga aagatttgaa acagttggca tggaggctgc     3000

gactgatgaa ggcatgccta aaagttactt accacagact gtacggcaag gcggctacat     3060

gcctcagtga aggactagta gttcctgcta caacttcagc agtacctata aagtaaagct     3120

aaaatgattt tatctgtgaa ttcagatttt aaaaagtctt cactctctga agatgatcat     3180

ttgcccttaa ggacaaaaat gaactgaagt ttcacatgag ctatttccat tccagaatat     3240

ctgggattct actttaagca ctacataaac tgactttatc ctcagactag ctgaatgatt     3300

ttgtgctgtt tcaggatgtt tgcactgaag aaaaacagaa agcttatctg aaatttataa     3360

aactttttgt tttgctacat agaaaacaga aggtatttga ataataagca gtgatatgct     3420

tagtgagcac agctatactg attttgatta gaatagtcat cagagtggct tagggacagt     3480

taatataaaa gaggagcaag gtgtagacca tcatctactt ctgctaaaat aacttaaaaa     3540

gaggtccata ggccataact acatgagccc agcttttgta atctgacaaa aaaatgagga     3600

gcagcttcgt gtatatcagt gtacacggta ttccttaggt cccttccatt ggtagtgatg     3660

ctgcgagtta ttactggaga aaaggaattc tagagcttta acttggcaga ttaaaagtac     3720

tcatttttta ttcatcaata attagtaatc tcactagttt tcaaaaattt gcatattatt     3780

gacaacctct ttgaagatgc atttcacaaa ctcaacagag tgccatgata agagctaggg     3840

atcccccaaa ctatctcaag catctaaaaa attgccattt ttaaaggctt aaattgtagt     3900

agtaaagggg aaaacaggaa gtagtagtaa aggggaaaaa aaaccaataa agcatctaaa     3960

aaattggcat gttaaaaggc ttaaattgct aatgtgtgta tatatatata tatatataca     4020

cacacatatc attgactttt cttaagactt cagagtactg ggtagatgaa cactttatac     4080

agtatatatc ttcagcttaa atttgttttg agtatttttt ttatttttaa ataagtaggc     4140

aaagatttaa atttttttat ttttagtaaa tgtttgaggc acactaagac aacttgggca     4200

atatttgcca aaacaaaaca gaaccccaaa aaatgtacat cttgttctta gcaaatatca     4260

ttattgtaga gacacttaat aaagagatgg tattttaatg tctgcagttc tgaggtaggg     4320

tggaacttag ttctacattg tgatttagga atttttaaaa ccttttttct tcaagggaga     4380

agtgacccag gcctcgagtt tagtgctaaa gccgctagtg tacttatgct gtcccctaac     4440

caccacgtgc gatatggaag cagatgctaa atataggggt tttcttagaa agtaagagga     4500

aattagcaag cgttattagt gattgactac tgctatcaag tgaattcaaa ggaaacaggt     4560

ttttatgcca tatttaagtt acagaaacca ggcatgctta gaatagtttc tagaggttat     4620

tggagaatag aaagctaaga aaacttggta tacatttaca atggaaatat aattacactt     4680

tttactctca gaatattgtt cacattagac ttcctgttta tcttttatat tcttgcattt     4740

atataatgcc tcatcctttc aaagttcttt cacatattat atgatcttct ttatgaaaaa     4800

aatagatgtt tcattctgat atattcagtt tcccacttta ggcaaaagta gattaataga     4860

atgacgaatt caaagtagat gaggaaaatc aggcacagag aagtaaaggt agggatagac     4920

ccaaatttac acaacaagat aatgacatct ccagctttta agttgatcat caaaggctgg     4980

gctggatttg tcttgctgta tgtgtcagga aatttatacc tattacattt tccattttct     5040

caaaatttaa gtcacatgac taatatttag ctgcaacttt cctcataaca aatagtgtca     5100

tgaagaatgt tgtagtgtga agtttgtaca tttcagggtc agatatacaa tatgaactct     5160

taatctacag gaatgagaat ggaggatcat tgaaggccat gatataaaca aatttgcatg     5220

ttgaagcctg tataaaacat ggtacagtga gtgaatatac ccccatcccc aagaacactt     5280

tatacatatt aaatggatat atgattactg tgcaaaaatt cattctggaa atgaacatat     5340

atttgagcac taatatgtaa tgtacacctg ccctaaggag aaaataaatt ataaaacttt     5400

ttacattcaa aattactttc ccaagcatgt cttagaataa tctatgtgtt gatgcatgta     5460

aattgtactt taggtaggca aagaaatctg gttatttatg taaaaactag tctaataaag     5520

ttagttagtg gctttatcac tttaaatctt tagtgtccaa aagtggtgtt taaagtaata     5580

gcacatcaga aaaccttgtc tggacaaaac tagttcactc actgcttctg cacctgcagt     5640

tgctcccttt agggttataa aataatgacc caaatgttac atgtgttgat attataactt     5700

gtcagttact gatgtctgtg gtatcctacc ctcatctctg aaagggataa tactgaataa     5760

ttattagaaa actataaaac ttcacacttt gtaccattaa aacctaaaat tttaatcttg     5820

tcctttttta ctatggatca gtcggcactc gggaacagca gcaaggaaaa aaagcaaatt     5880

tcattcacat gttctgtgtt catacctctt ctctacctaa ttgttcattt aaatttcagc     5940

cttattcctt gataagggat tttaccacat gaagtcatcc agtgacccta gctcttattg     6000

tgaagttagt ggagtatact tagaaatgtt acaactttaa aatgttacaa aacattcatt     6060

aaagctcata tttaaagtag agcatctagt ttgagaaata gaaatcaatt attaaagatg     6120

tcttttttct acccatttaa ctagttaaaa ccatgacatg taaatgtaga agtagaataa     6180

tcatagaatt ccctaaaata tttctgttta ctaacatata ttgaccaagt acatcaagca     6240

ggagagatct tccttcattc tgttatagtc cacatcattc taattttgct cagttgttat     6300

taagagcata ttcctaaacc atacactttt gtttcaataa agttttattt tgttgagatg     6360

aataaaataa caaagttata agctgcataa gacaaaagtt caattgttca aaaaaaattt     6420

actgggatag ctttctatta caggtattgt tagattatat tgtgctgata agattacttt     6480

ctaaaaaatt tgtacttttc tgtaaattaa aagaatatgg agtcataaaa tggcaagtgt     6540

tttaggatta gcctaaaatt ggacattgtc attgatttca aagaaggtat gaactagcag     6600

tcttacagcc taattcttct ttggactggt ccttggcagc agttcctttt cagactcgat     6660

aaacagaatt cagatgatgt aagtcaaaac aaaactttac aaagccaagc gtattatctt     6720

ttgcattaac ctattttttt ccatcataca tgctactagt atgtgcatta gcatgatatt     6780

ctcatataca ttgcattaaa aattaaaagg tggcagctca gggtgagctc ttctgttgct     6840

catttgttcc taaattttta agggcttttt ctcagtcaat agtttgtaca aactggttag     6900

tttaacttca ttacccattt cattaaagtt gatgggtcgt gtgatgagat gcatttaagg     6960

ccgatagtga tagatgtttt ttttatttct tgaacacagg ctttgtctga atgatgttct     7020

tttatctctt gaacacaagc tttgaatgat aactacaggt tttaagtgct gttacattaa     7080

taccataatg tgatgtgtta gaaacaaagg gatatttcaa aggtagatat ttgaaaattc     7140

tctagtctca atatgtatgt gtattgaata tactctaaaa ataaatgtgc aatttgctag     7200

taggacaatg cagtgactga ctagcattag gtatgtttct tttatatcct agctatgtcc     7260

cactttcttc taagtgcaat cctttcatgt tcacttgctg ttttacccca tctactctaa     7320

cttcatttgg aaggcttgtc tagagtatag catgtatttt tacctttgca gtgaattgca     7380

tgtgctaatt gtaaccacag ctatttttat gttgacataa ctccaaatgt tatattaaat     7440

gttctattat atattagctc taatccctta agtaaatttt aagaaataaa tacttgttca     7500

aatttttttt ctgtatgtgg ttactatcat ctgactatgc atatttgtaa cagcatttat     7560

cattagtggt gttagctaaa taagcatctt agtgtaaatg agatgcttcg tgtgggtttt     7620

gtgacatttt aaatgacata atggaatgtg atttaaaaga aaaccagtac actatcttgg     7680

tcttaataac atagaatgga gatggcaaat ttatccacta gttttccaga tttactattt     7740

aatagctgag gtctgaaatc gtagcatcct ccctcctagt ggacattaaa aaaaaaaaaa     7800

aaaaaaaaaa cctacttggt tgtcaagagc ccaagtatgg aggtgctgcg ccatcttgtg     7860

gcctgtctgt gcccaccctg cactctgctg gagtctccat ccttgttgca gtgagacttg     7920

aagttcaaga ttgatacatg gcatcctcct gctacttctt gaggttacta agtagtatat     7980

gaaactaatc agtcagcaag tccacctgga aggaaaagaa aatctcaact attaatgtgc     8040

cttcacattg tgattttgtc taaaaaaatg tagtgagtca aaaaacccac aagccagcca     8100

acagtaactc cttcacatat ataccagagt ttatagaaat aacatgtcag ctttgggcta     8160

tgtgctcctt tgtttaaaat cttctatttg gttatggctt gtataggctc aagcctgatt     8220

tctttaaggt gtggtggctc atcttatcct aatgtgtatg atagatacag tccatcctgc     8280

tttggaaaag attatgtaac tccttgagag catactcttt ctctagccca aaggcagtga     8340

gagagttttc ttgttcagga ttgcttaact ttccatttaa gctttttctt tttaaattaa     8400

tacaaacttc tacactttca aaatacgaaa tatattacaa ctgcgtatag gctcttccat     8460

acttaagtcc agtgcttggg caagttaatg gagtgaaaga ctacaagcaa agaggaactg     8520

aggtagaaaa agaagaatgt gtgaaagcag caggaagctc agccaactcg aaagcagggt     8580

gaacagcttg agtcctgttg ctgctgatcg gggttggctc ttggacaact tagtaagatc     8640

atggaaaggc tgcttgggtt ctccatagaa aagttctgtc tccatcaagg gaggaaaatg     8700

tacctttcaa ctcaaaattc aatatttgtt tttaaatata gctattttcc ccaaccgcta     8760

aagattttca acagatacga agccagagct tagttttaga aacctgtgga cattcaaacc     8820

tgattcttta ttccctgtga ctatggttat gtcattttac atgtcaaaaa agtgtatcta     8880

gaattgtcat ttcttatttt tgagcttttt ttagtgagaa ttatcccctc acttaaatgg     8940

ctttttattt aaacatctgt gcattctgta tgaaattgta gtctttctgg gataacatgg     9000

tgagctatat ggtggtaatc cacacacaca aaaataaaag ccaaaaaaaa accaaaaaaa     9060

aaaaaaaaaa a                                                          9071


<210>  159
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  160
<211>  3159
<212>  DNA
<213>  Homo sapiens

<400>  160
gagcagccaa aaggcccgcg gagtcgcgct gggccgcccc ggcgcagctg aaccgggggc       60

cgcgcctgcc aggccgacgg gtctggccca gcctggcgcc aaggggttcg tgcgctgtgg      120

agacgcggag ggtcgaggcg gcgcggcctg agtgaaaccc aatggaaaaa gcatgacatt      180

tagaagtaga agacttagct tcaaatccct actccttcac ttactaattt tgtgatttgg      240

aaatatccgc gcaagatgtt gacgttgcag acttggctag tgcaagcctt gtttattttc      300

ctcaccactg aatctacagg tgaacttcta gatccatgtg gttatatcag tcctgaatct      360

ccagttgtac aacttcattc taatttcact gcagtttgtg tgctaaagga aaaatgtatg      420

gattattttc atgtaaatgc taattacatt gtctggaaaa caaaccattt tactattcct      480

aaggagcaat atactatcat aaacagaaca gcatccagtg tcacctttac agatatagct      540

tcattaaata ttcagctcac ttgcaacatt cttacattcg gacagcttga acagaatgtt      600

tatggaatca caataatttc aggcttgcct ccagaaaaac ctaaaaattt gagttgcatt      660

gtgaacgagg ggaagaaaat gaggtgtgag tgggatggtg gaagggaaac acacttggag      720

acaaacttca ctttaaaatc tgaatgggca acacacaagt ttgctgattg caaagcaaaa      780

cgtgacaccc ccacctcatg cactgttgat tattctactg tgtattttgt caacattgaa      840

gtctgggtag aagcagagaa tgcccttggg aaggttacat cagatcatat caattttgat      900

cctgtatata aagtgaagcc caatccgcca cataatttat cagtgatcaa ctcagaggaa      960

ctgtctagta tcttaaaatt gacatggacc aacccaagta ttaagagtgt tataatacta     1020

aaatataaca ttcaatatag gaccaaagat gcctcaactt ggagccagat tcctcctgaa     1080

gacacagcat ccacccgatc ttcattcact gtccaagacc ttaaaccttt tacagaatat     1140

gtgtttagga ttcgctgtat gaaggaagat ggtaagggat actggagtga ctggagtgaa     1200

gaagcaagtg ggatcaccta tgaagataac attgcctcct tttgaagcca atggaaaaat     1260

cttggattat gaagtgactc tcacaagatg gaaatcacat ttacaaaatt acacagttaa     1320

tgccacaaaa ctgacagtaa atctcacaaa tgatcgctat ctagcaaccc taacagtaag     1380

aaatcttgtt ggcaaatcag atgcagctgt tttaactatc cctgcctgtg actttcaagc     1440

tactcaccct gtaatggatc ttaaagcatt ccccaaagat aacatgcttt gggtggaatg     1500

gactactcca agggaatctg taaagaaata tatacttgag tggtgtgtgt tatcagataa     1560

agcaccctgt atcacagact ggcaacaaga agatggtacc gtgcatcgca cctatttaag     1620

agggaactta gcagagagca aatgctattt gataacagtt actccagtat atgctgatgg     1680

accaggaagc cctgaatcca taaaggcata ccttaaacaa gctccacctt ccaaaggacc     1740

tactgttcgg acaaaaaaag tagggaaaaa cgaagctgtc ttagagtggg accaacttcc     1800

tgttgatgtt cagaatggat ttatcagaaa ttatactata ttttatagaa ccatcattgg     1860

aaatgaaact gctgtgaatg tggattcttc ccacacagaa tatacattgt cctctttgac     1920

tagtgacaca ttgtacatgg tacgaatggc agcatacaca gatgaaggtg ggaaggatgg     1980

tccagaattc acttttacta ccccaaagtt tgctcaagga gaaattgaag ccatagtcgt     2040

gcctgtttgc ttagcattcc tattgacaac tcttctggga gtgctgttct gctttaataa     2100

gcgagaccta attaaaaaac acatctggcc taatgttcca gatccttcaa agagtcatat     2160

tgcccagtgg tcacctcaca ctcctccaag gcacaatttt aattcaaaag atcaaatgta     2220

ttcagatggc aatttcactg atgtaagtgt tgtggaaata gaagcaaatg acaaaaagcc     2280

ttttccagaa gatctgaaat cattggacct gttcaaaaag gaaaaaatta atactgaagg     2340

acacagcagt ggtattgggg ggtcttcatg catgtcatct tctaggccaa gcatttctag     2400

cagtgatgaa aatgaatctt cacaaaacac ttcgagcact gtccagtatt ctaccgtggt     2460

acacagtggc tacagacacc aagttccgtc agtccaagtc ttctcaagat ccgagtctac     2520

ccagcccttg ttagattcag aggagcggcc agaagatcta caattagtag atcatgtaga     2580

tggcggtgat ggtattttgc ccaggcaaca gtacttcaaa cagaactgca gtcagcatga     2640

atccagtcca gatatttcac attttgaaag gtcaaagcaa gtttcatcag tcaatgagga     2700

agattttgtt agacttaaac agcagatttc agatcatatt tcacaatcct gtggatctgg     2760

gcaaatgaaa atgtttcagg aagtttctgc agcagatgct tttggtccag gtactgaggg     2820

acaagtagaa agatttgaaa cagttggcat ggaggctgcg actgatgaag gcatgcctaa     2880

aagttactta ccacagactg tacggcaagg cggctacatg cctcagtgaa ggactagtag     2940

ttcctgctac aacttcagca gtacctataa agtaaagcta aaatgatttt atctgtgaat     3000

tcagatttta aaaagtcttc actctctgaa gatgatcatt tgcccttaag gacaaaaatg     3060

aactgaagtt tcacatgagc tatttccatt ccagaatatc tgggattcta ctttaagcac     3120

tacataaact gactttatcc tcagaaaaaa aaaaaaaaa                            3159


<210>  161
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Asn Ile Ala Ser Phe 
                325                 


<210>  162
<211>  3879
<212>  DNA
<213>  Homo sapiens

<400>  162
atcagacgcg cagaggaggc ggggccgcgg ctggtttcct gccggggggc ggctctgggc       60

cgccgagtcc cctcctcccg cccctgagga ggaggagccg ccgccacccg ccgcgcccga      120

cacccgggag gccccgccag cccgcgggag aggcccagcg ggagtcgcgg aacagcaggc      180

ccgagcccac cgcgccgggc cccggacgcc gcgcggaaaa gatgaattta caaccaattt      240

tctggattgg actgatcagt tcagtttgct gtgtgtttgc tcaaacagat gaaaatagat      300

gtttaaaagc aaatgccaaa tcatgtggag aatgtataca agcagggcca aattgtgggt      360

ggtgcacaaa ttcaacattt ttacaggaag gaatgcctac ttctgcacga tgtgatgatt      420

tagaagcctt aaaaaagaag ggttgccctc cagatgacat agaaaatccc agaggctcca      480

aagatataaa gaaaaataaa aatgtaacca accgtagcaa aggaacagca gagaagctca      540

agccagagga tattactcag atccaaccac agcagttggt tttgcgatta agatcagggg      600

agccacagac atttacatta aaattcaaga gagctgaaga ctatcccatt gacctctact      660

accttatgga cctgtcttac tcaatgaaag acgatttgga gaatgtaaaa agtcttggaa      720

cagatctgat gaatgaaatg aggaggatta cttcggactt cagaattgga tttggctcat      780

ttgtggaaaa gactgtgatg ccttacatta gcacaacacc agctaagctc aggaaccctt      840

gcacaagtga acagaactgc accagcccat ttagctacaa aaatgtgctc agtcttacta      900

ataaaggaga agtatttaat gaacttgttg gaaaacagcg catatctgga aatttggatt      960

ctccagaagg tggtttcgat gccatcatgc aagttgcagt ttgtggatca ctgattggct     1020

ggaggaatgt tacacggctg ctggtgtttt ccacagatgc cgggtttcac tttgctggag     1080

atgggaaact tggtggcatt gttttaccaa atgatggaca atgtcacctg gaaaataata     1140

tgtacacaat gagccattat tatgattatc cttctattgc tcaccttgtc cagaaactga     1200

gtgaaaataa tattcagaca atttttgcag ttactgaaga atttcagcct gtttacaagg     1260

agctgaaaaa cttgatccct aagtcagcag taggaacatt atctgcaaat tctagcaatg     1320

taattcagtt gatcattgat gcatacaatt ccctttcctc agaagtcatt ttggaaaacg     1380

gcaaattgtc agaaggcgta acaataagtt acaaatctta ctgcaagaac ggggtgaatg     1440

gaacagggga aaatggaaga aaatgttcca atatttccat tggagatgag gttcaatttg     1500

aaattagcat aacttcaaat aagtgtccaa aaaaggattc tgacagcttt aaaattaggc     1560

ctctgggctt tacggaggaa gtagaggtta ttcttcagta catctgtgaa tgtgaatgcc     1620

aaagcgaagg catccctgaa agtcccaagt gtcatgaagg aaatgggaca tttgagtgtg     1680

gcgcgtgcag gtgcaatgaa gggcgtgttg gtagacattg tgaatgcagc acagatgaag     1740

ttaacagtga agacatggat gcttactgca ggaaagaaaa cagttcagaa atctgcagta     1800

acaatggaga gtgcgtctgc ggacagtgtg tttgtaggaa gagggataat acaaatgaaa     1860

tttattctgg caaattctgc gagtgtgata atttcaactg tgatagatcc aatggcttaa     1920

tttgtggagg aaatggtgtt tgcaagtgtc gtgtgtgtga gtgcaacccc aactacactg     1980

gcagtgcatg tgactgttct ttggatacta gtacttgtga agccagcaac ggacagatct     2040

gcaatggccg gggcatctgc gagtgtggtg tctgtaagtg tacagatccg aagtttcaag     2100

ggcaaacgtg tgagatgtgt cagacctgcc ttggtgtctg tgctgagcat aaagaatgtg     2160

ttcagtgcag agccttcaat aaaggagaaa agaaagacac atgcacacag gaatgttcct     2220

attttaacat taccaaggta gaaagtcggg acaaattacc ccagccggtc caacctgatc     2280

ctgtgtccca ttgtaaggag aaggatgttg acgactgttg gttctatttt acgtattcag     2340

tgaatgggaa caacgaggtc atggttcatg ttgtggagaa tccagagtgt cccactggtc     2400

cagacatcat tccaattgta gctggtgtgg ttgctggaat tgttcttatt ggccttgcat     2460

tactgctgat atggaagctt ttaatgataa ttcatgacag aagggagttt gctaaatttg     2520

aaaaggagaa aatgaatgcc aaatgggaca cgggtgaaaa tcctatttat aagagtgccg     2580

taacaactgt ggtcaatccg aagtatgagg gaaaatgagt actgcccgtg caaatcccac     2640

aacactgaat gcaaagtagc aatttccata gtcacagtta ggtagcttta gggcaatatt     2700

gccatggttt tactcatgtg caggttttga aaatgtacaa tatgtataat ttttaaaatg     2760

ttttattatt ttgaaaataa tgttgtaatt catgccaggg actgacaaaa gacttgagac     2820

aggatggtta ctcttgtcag ctaaggtcac attgtgcctt tttgaccttt tcttcctgga     2880

ctattgaaat caagcttatt ggattaagtg atatttctat agcgattgaa agggcaatag     2940

ttaaagtaat gagcatgatg agagtttctg ttaatcatgt attaaaactg atttttagct     3000

ttacaaatat gtcagtttgc agttatgcag aatccaaagt aaatgtcctg ctagctagtt     3060

aaggattgtt ttaaatctgt tattttgcta tttgcctgtt agacatgact gatgacatat     3120

ctgaaagaca agtatgttga gagttgctgg tgtaaaatac gtttgaaata gttgatctac     3180

aaaggccatg ggaaaaattc agagagttag gaaggaaaaa ccaatagctt taaaacctgt     3240

gtgccatttt aagagttact taatgtttgg taacttttat gccttcactt tacaaattca     3300

agccttagat aaaagaaccg agcaattttc tgctaaaaag tccttgattt agcactattt     3360

acatacaggc catactttac aaagtatttg ctgaatgggg accttttgag ttgaatttat     3420

tttattattt ttattttgtt taatgtctgg tgctttctgt cacctcttct aatcttttaa     3480

tgtatttgtt tgcaattttg gggtaagact ttttttatga gtactttttc tttgaagttt     3540

tagcggtcaa tttgcctttt taatgaacat gtgaagttat actgtggcta tgcaacagct     3600

ctcacctacg cgagtcttac tttgagttag tgccataaca gaccactgta tgtttacttc     3660

tcaccatttg agttgcccat cttgtttcac actagtcaca ttcttgtttt aagtgccttt     3720

agttttaaca gttcactttt tacagtgcta tttactgaag ttatttatta aatatgccta     3780

aaatacttaa atcggatgtc ttgactctga tgtattttat caggttgtgt gcatgaaatt     3840

tttatagatt aaagaagttg aggaaaagca aaaaaaaaa                            3879


<210>  163
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  164
<211>  3388
<212>  DNA
<213>  Homo sapiens

<400>  164
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct       60

caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa      120

gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact      180

tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata      240

gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa      300

ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt      360

ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac      420

tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag      480

aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc      540

agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca      600

gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa      660

aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc      720

atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt      780

tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc      840

gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa      900

tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct      960

caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa     1020

tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta     1080

tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca     1140

gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac     1200

tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt     1260

ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct     1320

gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac     1380

atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga     1440

aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt     1500

gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac     1560

agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag     1620

agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt     1680

gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag     1740

tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa     1800

gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt     1860

acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt     1920

gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca     1980

tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc     2040

cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg     2100

ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat     2160

ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt     2220

gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga     2280

agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac ggtaagttac     2340

aaaacatcca aaaagcaaag tggcttataa agtaaatgta atactcctaa gacttatgta     2400

ttagctgtca ggctgattat taaagtcctt tctaagtatt ttattccccc aaaagtttct     2460

tactcaagga atttgcattt agtgaaaaac agaaagcatc ctaaatatat cccattgaaa     2520

caaaacattg attataagca tgtatattct ggttactgtg gccagtattt ttatttcttt     2580

aatagttttg atcctaaatc tgccttttca tctaatgtga agtagaatcc taaataatgt     2640

tatctgtgta gcaagctatt caatggaaag ctgcttcttt ctttaaaaca aacaaacaaa     2700

aaaaaccttc agtgaaagcc agattcaaaa ggttatatac caagcttgtc caactcgcag     2760

ctcgtcggcc aggacatgca gcccagaata gctttgaatg tggccccaac acaaatttgt     2820

aaactttctt agaaattgta attattatta ttattttttt ttggtaactt ttttttaaag     2880

ctcatcagct atcgttagtg tattttatgt gtggcccaag acaattcttc ttcttccagt     2940

gtggcccagg gaagccaaaa gattggacac ccctgctata tactatatga ttccatttag     3000

aggacattct ggaaaagcaa aactgtaggg gcaaaaatca gtggttgcta ggggctggaa     3060

tgggggaaag tgttgaccac agaggggcgt aagggatctt ccttgggatg atcttgattg     3120

tgggtggatt tatgtatttg aaaactcaca gaactatgta ctttaaaaag atgtatgttc     3180

ctctatgaaa attatatctc agtaaacttt ggcttataaa aatcttaaaa gccctaagtg     3240

accgaaaggt tatgttagca ttgagtgctt tgaaatatgg agtcagaggg tggggtaacc     3300

aaatgttggc ctttgtgtat tcatcttttg atacaagaaa gcaatgccaa tcttcagtat     3360

ttttaaattg taaatgaatt ttgtagtt                                        3388


<210>  165
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Val Ser Tyr Lys Thr Ser Lys 
    770                 775                 780                 


Lys Gln Ser Gly Leu 
785                 


<210>  166
<211>  3774
<212>  DNA
<213>  Homo sapiens

<400>  166
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct       60

caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa      120

gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact      180

tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata      240

gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa      300

ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt      360

ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac      420

tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag      480

aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc      540

agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca      600

gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa      660

aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc      720

atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt      780

tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc      840

gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa      900

tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct      960

caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa     1020

tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta     1080

tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca     1140

gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac     1200

tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt     1260

ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct     1320

gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac     1380

atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga     1440

aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt     1500

gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac     1560

agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag     1620

agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt     1680

gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag     1740

tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa     1800

gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt     1860

acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt     1920

gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca     1980

tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc     2040

cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg     2100

ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat     2160

ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt     2220

gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga     2280

agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gtctctctct     2340

gtcgcccagc ctggagtgca gtggtgtgat atcagctcac tgcaacctct gacttccaga     2400

ttccagcaat tctcctgcct cagcctcccg agtacctggg attacagggt gaaaatccta     2460

tttataagag tgccgtaaca actgtggtca atccgaagta tgagggaaaa tgagtactgc     2520

ccgtgcaaat cccacaacac tgaatgcaaa gtagcaattt ccatagtcac agttaggtag     2580

ctttagggca atattgccat ggttttactc atgtgcaggt tttgaaaatg tacaatatgt     2640

ataattttta aaatgtttta ttattttgaa aataatgttg taattcatgc cagggactga     2700

caaaagactt gagacaggat ggttactctt gtcagctaag gtcacattgt gcctttttga     2760

ccttttcttc ctggactatt gaaatcaagc ttattggatt aagtgatatt tctatagcga     2820

ttgaaagggc aatagttaaa gtaatgagca tgatgagagt ttctgttaat catgtattaa     2880

aactgatttt tagctttaca aatatgtcag tttgcagtta tgcagaatcc aaagtaaatg     2940

tcctgctagc tagttaagga ttgttttaaa tctgttattt tgctatttgc ctgttagaca     3000

tgactgatga catatctgaa agacaagtat gttgagagtt gctggtgtaa aatacgtttg     3060

aaatagttga tctacaaagg ccatgggaaa aattcagaga gttaggaagg aaaaaccaat     3120

agctttaaaa cctgtgtgcc attttaagag ttacttaatg tttggtaact tttatgcctt     3180

cactttacaa attcaagcct tagataaaag aaccgagcaa ttttctgcta aaaagtcctt     3240

gatttagcac tatttacata caggccatac tttacaaagt atttgctgaa tggggacctt     3300

ttgagttgaa tttattttat tatttttatt ttgtttaatg tctggtgctt tctgtcacct     3360

cttctaatct tttaatgtat ttgtttgcaa ttttggggta agactttttt tatgagtact     3420

ttttctttga agttttagcg gtcaatttgc ctttttaatg aacatgtgaa gttatactgt     3480

ggctatgcaa cagctctcac ctacgcgagt cttactttga gttagtgcca taacagacca     3540

ctgtatgttt acttctcacc atttgagttg cccatcttgt ttcacactag tcacattctt     3600

gttttaagtg cctttagttt taacagttca ctttttacag tgctatttac tgaagttatt     3660

tattaaatat gcctaaaata cttaaatcgg atgtcttgac tctgatgtat tttatcaggt     3720

tgtgtgcatg aaatttttat agattaaaga agttgaggaa aagcaaaaaa aaaa           3774


<210>  167
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Ser Leu Ser Val Ala Gln Pro 
    770                 775                 780                 


Gly Val Gln Trp Cys Asp Ile Ser Ser Leu Gln Pro Leu Thr Ser Arg 
785                 790                 795                 800 


Phe Gln Gln Phe Ser Cys Leu Ser Leu Pro Ser Thr Trp Asp Tyr Arg 
                805                 810                 815     


Val Lys Ile Leu Phe Ile Arg Val Pro 
            820                 825 


<210>  168
<211>  3739
<212>  DNA
<213>  Homo sapiens

<400>  168
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct       60

caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa      120

gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact      180

tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata      240

gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa      300

ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt      360

ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac      420

tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag      480

aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc      540

agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca      600

gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa      660

aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc      720

atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt      780

tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc      840

gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa      900

tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct      960

caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa     1020

tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta     1080

tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca     1140

gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac     1200

tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt     1260

ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct     1320

gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac     1380

atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga     1440

aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt     1500

gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac     1560

agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag     1620

agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt     1680

gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag     1740

tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa     1800

gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt     1860

acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt     1920

gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca     1980

tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc     2040

cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg     2100

ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat     2160

ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt     2220

gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga     2280

agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gcaagaaaat     2340

ccgatttaca agagtcctat taataatttc aagaatccaa actacggacg taaagctggt     2400

ctctaaattg ccggtgaaaa tcctatttat aagagtgccg taacaactgt ggtcaatccg     2460

aagtatgagg gaaaatgagt actgcccgtg caaatcccac aacactgaat gcaaagtagc     2520

aatttccata gtcacagtta ggtagcttta gggcaatatt gccatggttt tactcatgtg     2580

caggttttga aaatgtacaa tatgtataat ttttaaaatg ttttattatt ttgaaaataa     2640

tgttgtaatt catgccaggg actgacaaaa gacttgagac aggatggtta ctcttgtcag     2700

ctaaggtcac attgtgcctt tttgaccttt tcttcctgga ctattgaaat caagcttatt     2760

ggattaagtg atatttctat agcgattgaa agggcaatag ttaaagtaat gagcatgatg     2820

agagtttctg ttaatcatgt attaaaactg atttttagct ttacaaatat gtcagtttgc     2880

agttatgcag aatccaaagt aaatgtcctg ctagctagtt aaggattgtt ttaaatctgt     2940

tattttgcta tttgcctgtt agacatgact gatgacatat ctgaaagaca agtatgttga     3000

gagttgctgg tgtaaaatac gtttgaaata gttgatctac aaaggccatg ggaaaaattc     3060

agagagttag gaaggaaaaa ccaatagctt taaaacctgt gtgccatttt aagagttact     3120

taatgtttgg taacttttat gccttcactt tacaaattca agccttagat aaaagaaccg     3180

agcaattttc tgctaaaaag tccttgattt agcactattt acatacaggc catactttac     3240

aaagtatttg ctgaatgggg accttttgag ttgaatttat tttattattt ttattttgtt     3300

taatgtctgg tgctttctgt cacctcttct aatcttttaa tgtatttgtt tgcaattttg     3360

gggtaagact ttttttatga gtactttttc tttgaagttt tagcggtcaa tttgcctttt     3420

taatgaacat gtgaagttat actgtggcta tgcaacagct ctcacctacg cgagtcttac     3480

tttgagttag tgccataaca gaccactgta tgtttacttc tcaccatttg agttgcccat     3540

cttgtttcac actagtcaca ttcttgtttt aagtgccttt agttttaaca gttcactttt     3600

tacagtgcta tttactgaag ttatttatta aatatgccta aaatacttaa atcggatgtc     3660

ttgactctga tgtattttat caggttgtgt gcatgaaatt tttatagatt aaagaagttg     3720

aggaaaagca aaaaaaaaa                                                  3739


<210>  169
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr Gly Arg Lys Ala Gly 
785                 790                 795                 800 


Leu 
    


<210>  170
<211>  3756
<212>  DNA
<213>  Homo sapiens

<400>  170
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct       60

caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa      120

gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact      180

tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata      240

gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa      300

ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt      360

ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac      420

tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag      480

aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc      540

agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca      600

gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa      660

aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc      720

atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt      780

tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc      840

gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa      900

tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct      960

caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa     1020

tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta     1080

tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca     1140

gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac     1200

tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt     1260

ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct     1320

gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac     1380

atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga     1440

aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt     1500

gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac     1560

agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag     1620

agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt     1680

gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag     1740

tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa     1800

gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt     1860

acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt     1920

gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca     1980

tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc     2040

cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg     2100

ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat     2160

ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt     2220

gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga     2280

agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gcctggagtg     2340

cagtggtgtg atatcagctc actgcaacct ctgacttcca gattccagca attctcctgc     2400

ctcagcctcc cgagtacctg ggattacagg gtgaaaatcc tatttataag agtgccgtaa     2460

caactgtggt caatccgaag tatgagggaa aatgagtact gcccgtgcaa atcccacaac     2520

actgaatgca aagtagcaat ttccatagtc acagttaggt agctttaggg caatattgcc     2580

atggttttac tcatgtgcag gttttgaaaa tgtacaatat gtataatttt taaaatgttt     2640

tattattttg aaaataatgt tgtaattcat gccagggact gacaaaagac ttgagacagg     2700

atggttactc ttgtcagcta aggtcacatt gtgccttttt gaccttttct tcctggacta     2760

ttgaaatcaa gcttattgga ttaagtgata tttctatagc gattgaaagg gcaatagtta     2820

aagtaatgag catgatgaga gtttctgtta atcatgtatt aaaactgatt tttagcttta     2880

caaatatgtc agtttgcagt tatgcagaat ccaaagtaaa tgtcctgcta gctagttaag     2940

gattgtttta aatctgttat tttgctattt gcctgttaga catgactgat gacatatctg     3000

aaagacaagt atgttgagag ttgctggtgt aaaatacgtt tgaaatagtt gatctacaaa     3060

ggccatggga aaaattcaga gagttaggaa ggaaaaacca atagctttaa aacctgtgtg     3120

ccattttaag agttacttaa tgtttggtaa cttttatgcc ttcactttac aaattcaagc     3180

cttagataaa agaaccgagc aattttctgc taaaaagtcc ttgatttagc actatttaca     3240

tacaggccat actttacaaa gtatttgctg aatggggacc ttttgagttg aatttatttt     3300

attattttta ttttgtttaa tgtctggtgc tttctgtcac ctcttctaat cttttaatgt     3360

atttgtttgc aattttgggg taagactttt tttatgagta ctttttcttt gaagttttag     3420

cggtcaattt gcctttttaa tgaacatgtg aagttatact gtggctatgc aacagctctc     3480

acctacgcga gtcttacttt gagttagtgc cataacagac cactgtatgt ttacttctca     3540

ccatttgagt tgcccatctt gtttcacact agtcacattc ttgttttaag tgcctttagt     3600

tttaacagtt cactttttac agtgctattt actgaagtta tttattaaat atgcctaaaa     3660

tacttaaatc ggatgtcttg actctgatgt attttatcag gttgtgtgca tgaaattttt     3720

atagattaaa gaagttgagg aaaagcaaaa aaaaaa                               3756


<210>  171
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Pro Gly Val Gln Trp Cys Asp 
    770                 775                 780                 


Ile Ser Ser Leu Gln Pro Leu Thr Ser Arg Phe Gln Gln Phe Ser Cys 
785                 790                 795                 800 


Leu Ser Leu Pro Ser Thr Trp Asp Tyr Arg Val Lys Ile Leu Phe Ile 
                805                 810                 815     


Arg Val Pro 
            


<210>  172
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  172
gagccagccc agccgcgttc cgaacgtgag ggtcgccggc ctgggcgctg tcacgtcggg       60

gctgccggag ctgcggggga ccgggcccga acggcccctg acacctgcgg tctcccgccg      120

ggctgggcaa gcgcagatga atttacaacc aattttctgg attggactga tcagttcagt      180

ttgctgtgtg tttgctcaaa cagatgaaaa tagatgttta aaagcaaatg ccaaatcatg      240

tggagaatgt atacaagcag ggccaaattg tgggtggtgc acaaattcaa catttttaca      300

ggaaggaatg cctacttctg cacgatgtga tgatttagaa gccttaaaaa agaagggttg      360

ccctccagat gacatagaaa atcccagagg ctccaaagat ataaagaaaa ataaaaatgt      420

aaccaaccgt agcaaaggaa cagcagagaa gctcaagcca gaggatatta ctcagatcca      480

accacagcag ttggttttgc gattaagatc aggggagcca cagacattta cattaaaatt      540

caagagagct gaagactatc ccattgacct ctactacctt atggacctgt cttactcaat      600

gaaagacgat ttggagaatg taaaaagtct tggaacagat ctgatgaatg aaatgaggag      660

gattacttcg gacttcagaa ttggatttgg ctcatttgtg gaaaagactg tgatgcctta      720

cattagcaca acaccagcta agctcaggaa cccttgcaca agtgaacaga actgcaccag      780

cccatttagc tacaaaaatg tgctcagtct tactaataaa ggagaagtat ttaatgaact      840

tgttggaaaa cagcgcatat ctggaaattt ggattctcca gaaggtggtt tcgatgccat      900

catgcaagtt gcagtttgtg gatcactgat tggctggagg aatgttacac ggctgctggt      960

gttttccaca gatgccgggt ttcactttgc tggagatggg aaacttggtg gcattgtttt     1020

accaaatgat ggacaatgtc acctggaaaa taatatgtac acaatgagcc attattatga     1080

ttatccttct attgctcacc ttgtccagaa actgagtgaa aataatattc agacaatttt     1140

tgcagttact gaagaatttc agcctgttta caaggagctg aaaaacttga tccctaagtc     1200

agcagtagga acattatctg caaattctag caatgtaatt cagttgatca ttgatgcata     1260

caattccctt tcctcagaag tcattttgga aaacggcaaa ttgtcagaag gcgtaacaat     1320

aagttacaaa tcttactgca agaacggggt gaatggaaca ggggaaaatg gaagaaaatg     1380

ttccaatatt tccattggag atgaggttca atttgaaatt agcataactt caaataagtg     1440

tccaaaaaag gattctgaca gctttaaaat taggcctctg ggctttacgg aggaagtaga     1500

ggttattctt cagtacatct gtgaatgtga atgccaaagc gaaggcatcc ctgaaagtcc     1560

caagtgtcat gaaggaaatg ggacatttga gtgtggcgcg tgcaggtgca atgaagggcg     1620

tgttggtaga cattgtgaat gcagcacaga tgaagttaac agtgaagaca tggatgctta     1680

ctgcaggaaa gaaaacagtt cagaaatctg cagtaacaat ggagagtgcg tctgcggaca     1740

gtgtgtttgt aggaagaggg ataatacaaa tgaaatttat tctggcaaat tctgcgagtg     1800

tgataatttc aactgtgata gatccaatgg cttaatttgt ggaggaaatg gtgtttgcaa     1860

gtgtcgtgtg tgtgagtgca accccaacta cactggcagt gcatgtgact gttctttgga     1920

tactagtact tgtgaagcca gcaacggaca gatctgcaat ggccggggca tctgcgagtg     1980

tggtgtctgt aagtgtacag atccgaagtt tcaagggcaa acgtgtgaga tgtgtcagac     2040

ctgccttggt gtctgtgctg agcataaaga atgtgttcag tgcagagcct tcaataaagg     2100

agaaaagaaa gacacatgca cacaggaatg ttcctatttt aacattacca aggtagaaag     2160

tcgggacaaa ttaccccagc cggtccaacc tgatcctgtg tcccattgta aggagaagga     2220

tgttgacgac tgttggttct attttacgta ttcagtgaat gggaacaacg aggtcatggt     2280

tcatgttgtg gagaatccag agtgtcccac tggtccagac atcattccaa ttgtagctgg     2340

tgtggttgct ggaattgttc ttattggcct tgcattactg ctgatatgga agcttttaat     2400

gataattcat gacagaaggg agtttgctaa atttgaaaag gagaaaatga atgccaaatg     2460

ggacacgggt gaaaatccta tttataagag tgccgtaaca actgtggtca atccgaagta     2520

tgagggaaaa tgagtactgc ccgtgcaaat cccacaacac tgaatgcaaa gtagcaattt     2580

ccatagtcac agttaggtag ctttagggca atattgccat ggttttactc atgtgcaggt     2640

tttgaaaatg tacaatatgt ataattttta aaatgtttta ttattttgaa aataatgttg     2700

taattcatgc cagggactga caaaagactt gagacaggat ggttactctt gtcagctaag     2760

gtcacattgt gcctttttga ccttttcttc ctggactatt gaaatcaagc ttattggatt     2820

aagtgatatt tctatagcga ttgaaagggc aatagttaaa gtaatgagca tgatgagagt     2880

ttctgttaat catgtattaa aactgatttt tagctttaca aatatgtcag tttgcagtta     2940

tgcagaatcc aaagtaaatg tcctgctagc tagttaagga ttgttttaaa tctgttattt     3000

tgctatttgc ctgttagaca tgactgatga catatctgaa agacaagtat gttgagagtt     3060

gctggtgtaa aatacgtttg aaatagttga tctacaaagg ccatgggaaa aattcagaga     3120

gttaggaagg aaaaaccaat agctttaaaa cctgtgtgcc attttaagag ttacttaatg     3180

tttggtaact tttatgcctt cactttacaa attcaagcct tagataaaag aaccgagcaa     3240

ttttctgcta aaaagtcctt gatttagcac tatttacata caggccatac tttacaaagt     3300

atttgctgaa tggggacctt ttgagttgaa tttattttat tatttttatt ttgtttaatg     3360

tctggtgctt tctgtcacct cttctaatct tttaatgtat ttgtttgcaa ttttggggta     3420

agactttttt tatgagtact ttttctttga agttttagcg gtcaatttgc ctttttaatg     3480

aacatgtgaa gttatactgt ggctatgcaa cagctctcac ctacgcgagt cttactttga     3540

gttagtgcca taacagacca ctgtatgttt acttctcacc atttgagttg cccatcttgt     3600

ttcacactag tcacattctt gttttaagtg cctttagttt taacagttca ctttttacag     3660

tgctatttac tgaagttatt tattaaatat gcctaaaata cttaaatcgg atgtcttgac     3720

tctgatgtat tttatcaggt tgtgtgcatg aaatttttat agattaaaga agttgaggaa     3780

aagcaaaaaa aaaa                                                       3794


<210>  173
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  174
<211>  6704
<212>  DNA
<213>  Homo sapiens

<400>  174
ggcaacatgc cagccccgta gcactgccca ccccacccac tgtggtctgt tgtaccccac       60

tgctggggtg gtggttccaa tgagacaggg cacaccaaac tccatctggc tgttactgag      120

gcggagacac gggtgatgat tggctttctg gggagagagg aagtcctgtg attggccaga      180

tctctggagc ttgccgacgc ggtgtgagga cgctcccacg gaggccggaa ttggctgtga      240

aaggactgag gcagccatct gggggtagcg ggcactctta tcagagcggc tggagccgga      300

ccatcgtccc agagagctgg ggcagggggc cgtgcccaat ctccagggct cctggggcca      360

ctgctgacct ggctggatgc atcgggcagt ggaccctcca ggggcccgcg ctgcacggga      420

agcctttgcc cttgggggcc tgagctgtgc tggggcctgg agctcctgcc cgcctcatcc      480

ccctcctcgt agcgcatggc tgcctggagg cagatgctca gccagcattg ggcagccccc      540

gcttcctgct cccctacccc cttcacatgg cagtagttct gggcacccca gcaaaccata      600

ttatgctcca ggggcgccca ctccaagacc cctccatggg aagctggaat ccctgcatgg      660

ctgtgtgcag gcattgctcc gggagccagc ccagccaggg ctttgggaac agcttgggca      720

actgtacgag tcagagcacg atagtgagga ggccacacgc tgctaccaca gcgcccttcg      780

atacggagga agcttcgctg agctggggcc ccgcattggc cgactgcagc aggcccagct      840

ctggaacttt catactggct cctgccagca ccgagccaag gtcctgcccc cactggagca      900

agtgtggaac ttgctacacc ttgagcacaa acggaactat ggagccaagc ggggaggtcc      960

cccggtgaag cgagctgctg aacccccagt ggtgcagcct gtgcctcctg cagcactctc     1020

aggcccctca ggggaggagg gcctcagccc tggaggcaag cgaaggagag gctgcaactc     1080

tgaacagact ggccttcccc cagggctgcc actgcctcca ccaccattac caccaccacc     1140

accaccacca ccaccaccac caccacccct gcctggcctg gctaccagcc ccccatttca     1200

gctaaccaag ccagggctgt ggagtaccct gcatggagat gcctggggcc cagagcgcaa     1260

gggttcagca cccccagagc gccaggagca gcggcactcg ctgcctcacc catatccata     1320

cccagctcca gcgtacaccg cgcacccccc tggccaccgg ctggtcccgg ctgctccccc     1380

aggcccaggc ccccgccccc caggagcaga gagccatggc tgcctgcctg ccacccgtcc     1440

ccccggaagt gaccttagag agagcagagt tcagaggtcg cggatggact ccagcgtttc     1500

accagcagca accaccgcct gcgtgcctta cgccccttcc cggccccctg gcctccccgg     1560

caccaccacc agcagcagca gtagcagcag cagcaacact ggtctccggg gcgtggagcc     1620

gaacccaggc attcccggcg ctgaccatta ccaaactccc gcgctggagg tctctcacca     1680

tggccgcctg gggccctcgg cacacagcag tcggaaaccg ttcttggggg ctcccgctgc     1740

cactccccac ctatccctgc cacctggacc ttcctcaccc cctccacccc cctgtccccg     1800

cctcttacgc cccccaccac cccctgcctg gttgaagggt ccggcctgcc gggcagcccg     1860

agaggatgga gagatcttag aagagctctt ctttgggact gagggacccc cccgccctgc     1920

cccaccaccc ctcccccatc gcgagggctt cttggggcct ccggcctccc gcttttctgt     1980

gggcactcag gattctcaca cccctcccac tcccccaacc ccaaccacca gcagtagcaa     2040

cagcaacagt ggcagccaca gcagcagccc tgctgggcct gtgtcctttc ccccaccacc     2100

ctatctggcc agaagtatag acccccttcc ccggcctccc agcccagcac agaaccccca     2160

ggacccacct cttgtacccc tgactcttgc cctgcctcca gcccctcctt cctcctgcca     2220

ccaaaatacc tcaggaagct tcaggcgccc ggagagcccc cggcccaggg tctccttccc     2280

aaagaccccc gaggtggggc cggggccacc cccaggcccc ctgagtaaag ccccccagcc     2340

tgtgccgccc ggggttgggg agctgcctgc ccgaggccct cgactctttg attttccccc     2400

cactccgctg gaggaccagt ttgaggagcc agccgaattc aagatcctac ctgatgggct     2460

ggccaacatc atgaagatgc tggacgaatc cattcgcaag gaagaggaac agcaacaaca     2520

cgaagcaggc gtggcccccc aacccccgct gaaggagccc tttgcatctc tgcagtctcc     2580

tttccccacc gacacagccc ccaccactac tgctcctgct gtcgccgtca ccaccaccac     2640

caccaccacc accaccacca cggccaccca ggaagaggag aagaagccac caccagccct     2700

accaccacca ccgcctctag ccaagttccc tccaccctct cagccacagc caccaccacc     2760

cccacccccc agcccggcca gcctgctcaa atccttggcc tccgtgctgg agggacaaaa     2820

gtactgttat cgggggactg gagcagctgt ttccacccgg cctgggccct tgcccaccac     2880

tcagtattcc cctggccccc catcaggtgc taccgccctg ccgcccacct cagcggcccc     2940

tagcgcccag ggctccccac agccctctgc ttcctcgtca tctcagttct ctacctcagg     3000

cgggccctgg gcccgggagc gcagggcggg cgaagagcca gtcccgggcc ccatgacccc     3060

cacccaaccg cccccacccc tatctctgcc ccctgctcgc tctgagtctg aggtgctaga     3120

agagatcagc cgggcttgcg agacccttgt ggagcgggtg ggccggagtg ccactgaccc     3180

agccgaccca gtggacacag cagagccagc ggacagtggg actgagcgac tgctgccccc     3240

cgcacaggcc aaggaggagg ctggcggggt ggcggcagtg tcaggcagct gtaagcggcg     3300

acagaaggag catcagaagg agcatcggcg gcacaggcgg gcctgtaagg acagtgtggg     3360

tcgtcggccc cgtgagggca gggcaaaggc caaggccaag gtccccaaag aaaagagccg     3420

ccgggtgctg gggaacctgg acctgcagag cgaggagatc cagggtcgtg agaagtcccg     3480

gcccgatctt ggcggggcct ccaaggccaa gccacccaca gctccagccc ctccatcagc     3540

tcctgcacct tctgcccagc ccacaccccc gtcagcctct gtccctggaa agaaggctcg     3600

ggaggaagcc ccagggccac cgggtgtcag ccgggccgac atgctgaagc tgcgctcact     3660

tagtgagggg ccccccaagg agctgaagat ccggctcatc aaggtagaga gtggtgacaa     3720

ggagaccttt atcgcctctg aggtggaaga gcggcggctg cgcatggcag acctcaccat     3780

cagccactgt gctgctgacg tcgtgcgcgc cagcaggaat gccaaggtga aagggaagtt     3840

tcgagagtcc tacctttccc ctgcccagtc tgtgaaaccg aagatcaaca ctgaggagaa     3900

gctgccccgg gaaaaactca acccccctac acccagcatc tatctggaga gcaaacggga     3960

tgccttctca cctgtcctgc tgcagttctg tacagaccct cgaaatccca tcacagtgat     4020

ccggggcctg gcgggctccc tgcggctcaa cttgggcctc ttctccacca agaccctggt     4080

ggaagcgagt ggcgaacaca ccgtggaagt tcgcacccag gtgcagcagc cctcagatga     4140

gaactgggat ctgacaggca ctcggcagat ctggccttgt gagagctccc gttcccacac     4200

caccattgcc aagtacgcac agtaccaggc ctcatccttc caggagtctc tgcaggagga     4260

gaaggagagt gaggatgagg agtcagagga gccagacagc accactggaa cccctcctag     4320

cagcgcacca gacccgaaga accatcacat catcaagttt ggcaccaaca tcgacttgtc     4380

tgatgctaag cggtggaagc cccagctgca ggagctgctg aagctgcccg ccttcatgcg     4440

ggtaacatcc acgggcaaca tgctgagcca cgtgggccac accatcctgg gcatgaacac     4500

ggtgcagctg tacatgaagg tgcccggcag ccgaacgcca ggccaccagg agaataacaa     4560

cttctgctcc gtcaacatca acattggccc aggcgactgc gagtggttcg cggtgcacga     4620

gcactactgg gagaccatca gcgctttctg tgatcggcac ggcgtggact acttgacggg     4680

ttcctggtgg ccaatcctgg atgatctcta tgcatccaat attcctgtgt accgcttcgt     4740

gcagcgaccc ggagacctcg tgtggattaa tgcggggact gtgcactggg tgcaggccac     4800

cggctggtgc aacaacattg cctggaacgt ggggcccctc accgcctatc agtaccagct     4860

ggccctggaa cgatacgagt ggaatgaggt gaagaacgtc aaatccatcg tgcccatgat     4920

tcacgtgtca tggaacgtgg ctcgcacggt caaaatcagc gaccccgact tgttcaagat     4980

gatcaagttc tgcctgctgc agtccatgaa gcactgccag gtgcaacgcg agagcctggt     5040

gcgggcaggg aagaaaatcg cttaccaggg ccgtgtcaag gacgagccag cctactactg     5100

caacgagtgc gatgtggagg tgtttaacat cctgttcgtg acaagtgaga atggcagccg     5160

caacacgtac ctggtacact gcgagggctg tgcccggcgc cgcagcgcag gcctgcaggg     5220

cgtggtggtg ctggagcagt accgcactga ggagctggct caggcctacg acgccttcac     5280

gctggtgagg gcccggcggg cgcgcgggca gcggaggagg gcactggggc aggctgcagg     5340

gacgggcttc gggagcccgg ccgcgccttt ccctgagccc ccgccggctt tctcccccca     5400

ggccccagcc agcacgtcgc gatgaggccg gacgccccgc ccgcctgcct gcccgcgcaa     5460

ggcgccgcgg ggccaccagc acatgcctgg gctggaccta ggtcccgcct gtggccgaga     5520

agggggtcgg gcccagccct tccaccccat tggcagctcc cctcacttaa tttattaaga     5580

aaaacttttt tttttttttt agcaaatatg aggaaaaaag gaaaaaaaat gggagacggg     5640

ggagggggct ggcagcccct cgcccaccag cgcctcccct caccgacttt ggccttttta     5700

gcaacagaca caaggaccag gctccggcgg cggcgggggt cacatacggg ttccctcacc     5760

ctgccagccg cccgcccgcc cggcgcagat gcacgcggct cgtgtatgta catagacgtt     5820

acggcagccg aggtttttaa tgagattctt tctatgggct ttacccctcc cccggaacct     5880

ccttttttac ttccaatgct agctgtgacc cctgtacatg tctctttatt cacttggtta     5940

tgatttgtat tttttgttct tttcttgttt ttttgttttt aatttataac agtcccactc     6000

acctctattt attcattttt gggaaaaccc gacctcccac acccccaagc catcctgccc     6060

gcccctccag ggaccgcccg tcgccgggct ctccccgcgc cccagtgtgt gtccgggccc     6120

ggcccgaccg tctccacccg tccgcccgcg gctccagccg ggttctcatg gtgctcaaac     6180

ccgctcccct cccctacgtc ctgcactttc tcggaccagt ccccccactc ccgacccgac     6240

cccagcccca cctgagggtg agcaactcct gtactgtagg ggaagaagtg ggaactgaaa     6300

tggtattttg taaaaaaaat aaataaaata aaaaaattaa aggttttaaa gaaagaacta     6360

tgaggaaaag gaaccccgtc cttcccagcc ccggccaact ttaaaaaaca cagaccttca     6420

cccccacccc cttttctttt taagtgtgaa acaacccagg gccagggcct cactggggca     6480

gggacacccc ggggtgagtt tctctggggc tttattttcg ttttgttggt tgttttttct     6540

ccacgctggg gctgcggagg ggtggggggt ttacagtccc gcaccctcgc actgcactgt     6600

ctctctgccc caggggcaga ggggtcttcc caaccctacc cctattttcg gtgatttttg     6660

tgtgagaata ttaatattaa aaataaacgg agaaaaaaaa tcct                      6704


<210>  175
<211>  1682
<212>  PRT
<213>  Homo sapiens

<400>  175

Met His Arg Ala Val Asp Pro Pro Gly Ala Arg Ala Ala Arg Glu Ala 
1               5                   10                  15      


Phe Ala Leu Gly Gly Leu Ser Cys Ala Gly Ala Trp Ser Ser Cys Pro 
            20                  25                  30          


Pro His Pro Pro Pro Arg Ser Ala Trp Leu Pro Gly Gly Arg Cys Ser 
        35                  40                  45              


Ala Ser Ile Gly Gln Pro Pro Leu Pro Ala Pro Leu Pro Pro Ser His 
    50                  55                  60                  


Gly Ser Ser Ser Gly His Pro Ser Lys Pro Tyr Tyr Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Thr Pro Arg Pro Leu His Gly Lys Leu Glu Ser Leu His Gly Cys 
                85                  90                  95      


Val Gln Ala Leu Leu Arg Glu Pro Ala Gln Pro Gly Leu Trp Glu Gln 
            100                 105                 110         


Leu Gly Gln Leu Tyr Glu Ser Glu His Asp Ser Glu Glu Ala Thr Arg 
        115                 120                 125             


Cys Tyr His Ser Ala Leu Arg Tyr Gly Gly Ser Phe Ala Glu Leu Gly 
    130                 135                 140                 


Pro Arg Ile Gly Arg Leu Gln Gln Ala Gln Leu Trp Asn Phe His Thr 
145                 150                 155                 160 


Gly Ser Cys Gln His Arg Ala Lys Val Leu Pro Pro Leu Glu Gln Val 
                165                 170                 175     


Trp Asn Leu Leu His Leu Glu His Lys Arg Asn Tyr Gly Ala Lys Arg 
            180                 185                 190         


Gly Gly Pro Pro Val Lys Arg Ala Ala Glu Pro Pro Val Val Gln Pro 
        195                 200                 205             


Val Pro Pro Ala Ala Leu Ser Gly Pro Ser Gly Glu Glu Gly Leu Ser 
    210                 215                 220                 


Pro Gly Gly Lys Arg Arg Arg Gly Cys Asn Ser Glu Gln Thr Gly Leu 
225                 230                 235                 240 


Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Leu Ala Thr Ser Pro 
            260                 265                 270         


Pro Phe Gln Leu Thr Lys Pro Gly Leu Trp Ser Thr Leu His Gly Asp 
        275                 280                 285             


Ala Trp Gly Pro Glu Arg Lys Gly Ser Ala Pro Pro Glu Arg Gln Glu 
    290                 295                 300                 


Gln Arg His Ser Leu Pro His Pro Tyr Pro Tyr Pro Ala Pro Ala Tyr 
305                 310                 315                 320 


Thr Ala His Pro Pro Gly His Arg Leu Val Pro Ala Ala Pro Pro Gly 
                325                 330                 335     


Pro Gly Pro Arg Pro Pro Gly Ala Glu Ser His Gly Cys Leu Pro Ala 
            340                 345                 350         


Thr Arg Pro Pro Gly Ser Asp Leu Arg Glu Ser Arg Val Gln Arg Ser 
        355                 360                 365             


Arg Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro 
    370                 375                 380                 


Tyr Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn 
                405                 410                 415     


Pro Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val 
            420                 425                 430         


Ser His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro 
        435                 440                 445             


Phe Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly 
    450                 455                 460                 


Pro Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro 
465                 470                 475                 480 


Pro Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu 
                485                 490                 495     


Asp Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro 
            500                 505                 510         


Arg Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro 
        515                 520                 525             


Pro Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro 
    530                 535                 540                 


Thr Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser 
545                 550                 555                 560 


His Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr 
                565                 570                 575     


Leu Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln 
            580                 585                 590         


Asn Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro 
        595                 600                 605             


Ala Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg 
    610                 615                 620                 


Pro Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val 
625                 630                 635                 640 


Gly Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val 
                645                 650                 655     


Pro Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp 
            660                 665                 670         


Phe Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe 
        675                 680                 685             


Lys Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu 
    690                 695                 700                 


Ser Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala 
705                 710                 715                 720 


Pro Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe 
                725                 730                 735     


Pro Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr 
            740                 745                 750         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu 
        755                 760                 765             


Lys Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe 
    770                 775                 780                 


Pro Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro 
785                 790                 795                 800 


Ala Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr 
                805                 810                 815     


Cys Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu 
            820                 825                 830         


Pro Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu 
        835                 840                 845             


Pro Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser 
    850                 855                 860                 


Ala Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg 
865                 870                 875                 880 


Glu Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr 
                885                 890                 895     


Gln Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu 
            900                 905                 910         


Val Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val 
        915                 920                 925             


Gly Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro 
    930                 935                 940                 


Ala Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu 
945                 950                 955                 960 


Glu Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln 
                965                 970                 975     


Lys Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp 
            980                 985                 990         


Ser Val Gly Arg Arg Pro Arg Glu  Gly Arg Ala Lys Ala  Lys Ala Lys 
        995                 1000                 1005             


Val Pro  Lys Glu Lys Ser Arg  Arg Val Leu Gly Asn  Leu Asp Leu 
    1010                 1015                 1020             


Gln Ser  Glu Glu Ile Gln Gly  Arg Glu Lys Ser Arg  Pro Asp Leu 
    1025                 1030                 1035             


Gly Gly  Ala Ser Lys Ala Lys  Pro Pro Thr Ala Pro  Ala Pro Pro 
    1040                 1045                 1050             


Ser Ala  Pro Ala Pro Ser Ala  Gln Pro Thr Pro Pro  Ser Ala Ser 
    1055                 1060                 1065             


Val Pro  Gly Lys Lys Ala Arg  Glu Glu Ala Pro Gly  Pro Pro Gly 
    1070                 1075                 1080             


Val Ser  Arg Ala Asp Met Leu  Lys Leu Arg Ser Leu  Ser Glu Gly 
    1085                 1090                 1095             


Pro Pro  Lys Glu Leu Lys Ile  Arg Leu Ile Lys Val  Glu Ser Gly 
    1100                 1105                 1110             


Asp Lys  Glu Thr Phe Ile Ala  Ser Glu Val Glu Glu  Arg Arg Leu 
    1115                 1120                 1125             


Arg Met  Ala Asp Leu Thr Ile  Ser His Cys Ala Ala  Asp Val Val 
    1130                 1135                 1140             


Arg Ala  Ser Arg Asn Ala Lys  Val Lys Gly Lys Phe  Arg Glu Ser 
    1145                 1150                 1155             


Tyr Leu  Ser Pro Ala Gln Ser  Val Lys Pro Lys Ile  Asn Thr Glu 
    1160                 1165                 1170             


Glu Lys  Leu Pro Arg Glu Lys  Leu Asn Pro Pro Thr  Pro Ser Ile 
    1175                 1180                 1185             


Tyr Leu  Glu Ser Lys Arg Asp  Ala Phe Ser Pro Val  Leu Leu Gln 
    1190                 1195                 1200             


Phe Cys  Thr Asp Pro Arg Asn  Pro Ile Thr Val Ile  Arg Gly Leu 
    1205                 1210                 1215             


Ala Gly  Ser Leu Arg Leu Asn  Leu Gly Leu Phe Ser  Thr Lys Thr 
    1220                 1225                 1230             


Leu Val  Glu Ala Ser Gly Glu  His Thr Val Glu Val  Arg Thr Gln 
    1235                 1240                 1245             


Val Gln  Gln Pro Ser Asp Glu  Asn Trp Asp Leu Thr  Gly Thr Arg 
    1250                 1255                 1260             


Gln Ile  Trp Pro Cys Glu Ser  Ser Arg Ser His Thr  Thr Ile Ala 
    1265                 1270                 1275             


Lys Tyr  Ala Gln Tyr Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Gln 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ser Glu Asp  Glu Glu Ser Glu Glu  Pro Asp Ser 
    1295                 1300                 1305             


Thr Thr  Gly Thr Pro Pro Ser  Ser Ala Pro Asp Pro  Lys Asn His 
    1310                 1315                 1320             


His Ile  Ile Lys Phe Gly Thr  Asn Ile Asp Leu Ser  Asp Ala Lys 
    1325                 1330                 1335             


Arg Trp  Lys Pro Gln Leu Gln  Glu Leu Leu Lys Leu  Pro Ala Phe 
    1340                 1345                 1350             


Met Arg  Val Thr Ser Thr Gly  Asn Met Leu Ser His  Val Gly His 
    1355                 1360                 1365             


Thr Ile  Leu Gly Met Asn Thr  Val Gln Leu Tyr Met  Lys Val Pro 
    1370                 1375                 1380             


Gly Ser  Arg Thr Pro Gly His  Gln Glu Asn Asn Asn  Phe Cys Ser 
    1385                 1390                 1395             


Val Asn  Ile Asn Ile Gly Pro  Gly Asp Cys Glu Trp  Phe Ala Val 
    1400                 1405                 1410             


His Glu  His Tyr Trp Glu Thr  Ile Ser Ala Phe Cys  Asp Arg His 
    1415                 1420                 1425             


Gly Val  Asp Tyr Leu Thr Gly  Ser Trp Trp Pro Ile  Leu Asp Asp 
    1430                 1435                 1440             


Leu Tyr  Ala Ser Asn Ile Pro  Val Tyr Arg Phe Val  Gln Arg Pro 
    1445                 1450                 1455             


Gly Asp  Leu Val Trp Ile Asn  Ala Gly Thr Val His  Trp Val Gln 
    1460                 1465                 1470             


Ala Thr  Gly Trp Cys Asn Asn  Ile Ala Trp Asn Val  Gly Pro Leu 
    1475                 1480                 1485             


Thr Ala  Tyr Gln Tyr Gln Leu  Ala Leu Glu Arg Tyr  Glu Trp Asn 
    1490                 1495                 1500             


Glu Val  Lys Asn Val Lys Ser  Ile Val Pro Met Ile  His Val Ser 
    1505                 1510                 1515             


Trp Asn  Val Ala Arg Thr Val  Lys Ile Ser Asp Pro  Asp Leu Phe 
    1520                 1525                 1530             


Lys Met  Ile Lys Phe Cys Leu  Leu Gln Ser Met Lys  His Cys Gln 
    1535                 1540                 1545             


Val Gln  Arg Glu Ser Leu Val  Arg Ala Gly Lys Lys  Ile Ala Tyr 
    1550                 1555                 1560             


Gln Gly  Arg Val Lys Asp Glu  Pro Ala Tyr Tyr Cys  Asn Glu Cys 
    1565                 1570                 1575             


Asp Val  Glu Val Phe Asn Ile  Leu Phe Val Thr Ser  Glu Asn Gly 
    1580                 1585                 1590             


Ser Arg  Asn Thr Tyr Leu Val  His Cys Glu Gly Cys  Ala Arg Arg 
    1595                 1600                 1605             


Arg Ser  Ala Gly Leu Gln Gly  Val Val Val Leu Glu  Gln Tyr Arg 
    1610                 1615                 1620             


Thr Glu  Glu Leu Ala Gln Ala  Tyr Asp Ala Phe Thr  Leu Val Arg 
    1625                 1630                 1635             


Ala Arg  Arg Ala Arg Gly Gln  Arg Arg Arg Ala Leu  Gly Gln Ala 
    1640                 1645                 1650             


Ala Gly  Thr Gly Phe Gly Ser  Pro Ala Ala Pro Phe  Pro Glu Pro 
    1655                 1660                 1665             


Pro Pro  Ala Phe Ser Pro Gln  Ala Pro Ala Ser Thr  Ser Arg 
    1670                 1675                 1680         


<210>  176
<211>  2514
<212>  DNA
<213>  Homo sapiens

<400>  176
aaagtgccac ggtggcggtg gtggcggccg cgaggccgag tgtctccggc cctgccagcc       60

tcgcaaccgt aacctgtaat cccgacccga gggacgcccg ccggggaggc gccagcccgc      120

ctctccctgc ggccgctggt cggctccgac ctcgaatcac ccggctcacc cgcgggtcgc      180

agcacctgcc ggatgtgggg aggaagaagg aggccagatg agggaaggcg gatgtaggcg      240

cccagtctgt ccgcgccttg gtggggcagc tgggtgggca agcctgcggt cgctcccggg      300

aaccagccct gggctgcggg gagacgaagg tggttggtcc tgccctccag gagcgccccg      360

acatcgacgt aaaatgactt ggcaccagag ctcctgccgc ctccccctta tgcagctgcc      420

ctcgccgacg ccagggactg taaaatcaga tgggacaggg cctagccgtt cagccaacac      480

tttgagcttc ccagccaaac tcctaccccc actccccgcc tccggtcctc acccccttcc      540

tctctcccag cctcggtgtc tggttacggc tcctctgctc gcattgtgac tttgggccag      600

gctgggggaa atgacccggg agggtcccat gcggctacat aaaattggca gccttagaac      660

tagtgggaag gcgggtgcgc gaagtcgagg ggcggagaga gggggccgga ggagctgctt      720

tctgaatcca agttcgtggg ctctctcaga agtcctcagg acggagcaga ggtggccggc      780

gggcccggct gactgcgcct ctgctttctt tccataacct tttctttcgg actcgaatca      840

cggctgctgc gaagggtcta gttccggaca ctagggtgcc cgaacgcgct gatgccccga      900

gtgctcgcag ggcttcccgc taaccatgct gccgccgccg cggcccgcag ctgccttggc      960

gctgcctgtg ctcctgctac tgctggtggt gctgacgccg cccccgaccg gcgcaaggcc     1020

atccccaggc ccagattacc tgcggcgcgg ctggatgcgg ctgctagcgg agggcgaggg     1080

ctgcgctccc tgccggccag aagagtgcgc cgcgccgcgg ggctgcctgg cgggcagggt     1140

gcgcgacgcg tgcggctgct gctgggaatg cgccaacctc gagggccagc tctgcgacct     1200

ggaccccagt gctcacttct acgggcactg cggcgagcag cttgagtgcc ggctggacac     1260

aggcggcgac ctgagccgcg gagaggtgcc ggaacctctg tgtgcctgtc gttcgcagag     1320

tccgctctgc gggtccgacg gtcacaccta ctcccagatc tgccgcctgc aggaggcggc     1380

ccgcgctcgg cccgatgcca acctcactgt ggcacacccg gggccctgcg aatcggggcc     1440

ccagatcgtg tcacatccat atgacacttg gaatgtgaca gggcaggatg tgatctttgg     1500

ctgtgaagtg tttgcctacc ccatggcctc catcgagtgg aggaaggatg gcttggacat     1560

ccagctgcca ggggatgacc cccacatctc tgtgcagttt aggggtggac cccagaggtt     1620

tgaggtgact ggctggctgc agatccaggc tgtgcgtccc agtgatgagg gcacttaccg     1680

ctgccttggc cgcaatgccc tgggtcaagt ggaggcccct gctagcttga cagtgctcac     1740

acctgaccag ctgaactcta caggcatccc ccagctgcga tcactaaacc tggttcctga     1800

ggaggaggct gagagtgaag agaatgacga ttactactag gtccagagct ctggcccatg     1860

ggggtgggtg agcggctata gtgttcatcc ctgctcttga aaagacctgg aaaggggagc     1920

agggtccctt catcgactgc tttcatgctg tcagtaggga tgatcatggg aggcctattt     1980

gactccaagg tagcagtgtg gtaggataga gacaaaagct ggaggagggt agggagagaa     2040

gctgagacca ggaccggtgg ggtacaaagg ggcccatgca ggagatgccc tggccagtag     2100

gacctccaac aggttgtttc ccaggctggg gtgggggcct gagcagacac agaggtgcag     2160

gcaccaggat tctccacttc ttccagccct gctgggccac agttctaact gcccttcctc     2220

ccaggccctg gttcttgcta tttcctggtc cccaacgttt atctagcttg tttgcccttt     2280

ccccaaactc atcttccaga acttttccct ctctcctaag ccccagttgc acctactaac     2340

tgcagtccct tttgctgtct gccgtctttt gtacaagaga gagaacagcg gagcatgact     2400

tagttcagtg cagagagata ggtgaggcca gctcgagatc ttataccact ctgtattgga     2460

caaaggctag cacagggcta ggcaccaata aagatttcta atgatgcaca gaca           2514


<210>  177
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Leu Pro Pro Pro Arg Pro Ala Ala Ala Leu Ala Leu Pro Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro 
            20                  25                  30          


Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Met Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


His Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys 
        115                 120                 125             


Arg Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln 
    130                 135                 140                 


Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser 
                165                 170                 175     


His Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly 
            180                 185                 190         


Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp 
        195                 200                 205             


Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln 
    210                 215                 220                 


Phe Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile 
225                 230                 235                 240 


Gln Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Gly Arg 
                245                 250                 255     


Asn Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr 
            260                 265                 270         


Pro Asp Gln Leu Asn Ser Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn 
        275                 280                 285             


Leu Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr 
    290                 295                 300                 


<210>  178
<211>  2174
<212>  DNA
<213>  Homo sapiens

<400>  178
ctggaccggc gcggacttgc cccagaccta cggggagcgc cccaggtctt taatgacagc       60

ttaaatgtgg ctgttggaaa agtcgaaagg gatgtggctg acgtggggcg tgtttcgctc      120

ctttgcaaga gtcggaaagg gagttgggag ccgcgcggct ggccccaggc ccccgcgcct      180

cgccgccagc aagtaggtgg gggagccgcc gccgccgcca gccccatccc gctcccaagc      240

ctcgcccgct gcgccctggc cgcgggcgcc gagagggtgc ggggcctcgc cgtgcctcct      300

ccaccctgct cattaacctg cctgctccgc tccgctccgg gcggccccag acacgggttt      360

cccgcggcag cacccgcggc ccgcccggcg cagccgccgc cccgaccccc cggctccggg      420

gggcaatgag ggggcagtgg aaggggcact gctcctcggg cattacttag agaaacgaga      480

ccgtcccgcc ctctcgccgg ccctccctct ctcccgcccg ggcccgcgca attctccgcc      540

agagggacag tcggcccaat atgtcaagac ctctgatcac tagatcccct gcatctccac      600

tgaacaacca aggcatccct actccagcac aactcacaaa atccaatgcg cctgtccaca      660

ttgatgtggg cggccacatg tacaccagca gcctggccac cctcaccaaa taccctgaat      720

ccagaatcgg aagacttttt gatggtacag agcccattgt tttggacagt ctcaaacagc      780

actatttcat tgacagagat ggacagatgt tcagatatat cttgaatttt ctacgaacat      840

ccaaactcct cattcctgat gatttcaagg actacacttt gttatatgaa gaggcaaaat      900

attttcagct tcagcccatg ttgttggaga tggaaagatg gaagcaggac agagaaactg      960

gtcgattttc aaggccctgt gagtgcctcg tcgtgcgtgt ggccccagac ctcggagaaa     1020

ggatcacgct aagcggtgac aaatccttga tagaagaagt atttccagag atcggcgacg     1080

tgatgtgtaa ctctgtcaat gcaggctgga atcacgactc gacgcacgtc atcaggtttc     1140

cactaaatgg ctactgtcac ctcaactcag tccaggtcct cgagaggttg cagcaaagag     1200

gatttgaaat cgtgggctcc tgtgggggag gagtagactc gtcccagttc agcgaatacg     1260

tccttcggcg ggaactgagg cggacgcccc gtgtaccctc cgtcatccgg ataaagcaag     1320

agcctctgga ctaaatggac atatttctta tgcaaaaagg aaaacacaca caaccaataa     1380

ctcaaacaaa aaagggacat ttatgtgcag ttgggacagc aaaccaagtc ctggacgtaa     1440

aatcgaataa aagacacatt tatatccaat agagaccaca cctgtattca tatgggaaca     1500

attggaatag tgatatcctc aaggtgtaaa aaatatataa atatatatat atatgtcaaa     1560

aggtaggaaa tgcaaaaaag aaaaaaaaaa aaggtgacag ccgcagttgg tgctgtgatg     1620

gccgtgaagt gtcctgggcc ttccgaggcc tctgacaaat aaacaagcca tgagtggtga     1680

ggacacagtc tccttacagt ttccattgcc aacaacagcc atccatattt cttttttcct     1740

ttgtctttct ttttcctttt tttttaaaaa aacaaaacaa acaaaacacc ttgaatcaag     1800

tttgtttgta tatggaggtt ccacgtcttt ctttaggcag ggaccaggca ggacttcaga     1860

aaaaccctca tgagcacatt gcaaagatgt tagacatgaa attttaaatg tagtttgtac     1920

agaagtcaca cttttttgtc cacctcacag atgtgaactt tactttgttt taaaactgat     1980

cagttttgcc aaggggccag aattattcct tgttagaatt gctccagttc aagtctgctg     2040

ctttcctaca atttttcaaa ttttataatg tattaaatac aataaactct gtttaaaaaa     2100

taaggtctgt gtgaaacaca catgtggggg tgaggctgga ttaaagtgaa attttttctt     2160

tttgaaaaaa aaaa                                                       2174


<210>  179
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro Leu Asn Asn 
1               5                   10                  15      


Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn Ala Pro Val 
            20                  25                  30          


His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu Ala Thr Leu 
        35                  40                  45              


Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp Gly Thr Glu 
    50                  55                  60                  


Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile Asp Arg Asp 
65                  70                  75                  80  


Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr Ser Lys Leu 
                85                  90                  95      


Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala 
            100                 105                 110         


Lys Tyr Phe Gln Leu Gln Pro Met Leu Leu Glu Met Glu Arg Trp Lys 
        115                 120                 125             


Gln Asp Arg Glu Thr Gly Arg Phe Ser Arg Pro Cys Glu Cys Leu Val 
    130                 135                 140                 


Val Arg Val Ala Pro Asp Leu Gly Glu Arg Ile Thr Leu Ser Gly Asp 
145                 150                 155                 160 


Lys Ser Leu Ile Glu Glu Val Phe Pro Glu Ile Gly Asp Val Met Cys 
                165                 170                 175     


Asn Ser Val Asn Ala Gly Trp Asn His Asp Ser Thr His Val Ile Arg 
            180                 185                 190         


Phe Pro Leu Asn Gly Tyr Cys His Leu Asn Ser Val Gln Val Leu Glu 
        195                 200                 205             


Arg Leu Gln Gln Arg Gly Phe Glu Ile Val Gly Ser Cys Gly Gly Gly 
    210                 215                 220                 


Val Asp Ser Ser Gln Phe Ser Glu Tyr Val Leu Arg Arg Glu Leu Arg 
225                 230                 235                 240 


Arg Thr Pro Arg Val Pro Ser Val Ile Arg Ile Lys Gln Glu Pro Leu 
                245                 250                 255     


Asp 
    


<210>  180
<211>  3438
<212>  DNA
<213>  Homo sapiens

<400>  180
atggcgagaa tgcctggcag cggggactgt aacaccagcg cgggcggcag cgccagcgct       60

gccgccgccg ccgccgagaa caatggggag cggggcgagg gcgagcgcgg cgcggggggc      120

cgcggccgcc gccacagccg tccgcactac tgcagcgcgg gcgaggagga ggaggaagag      180

gaggaggagg acgagatcca ggaggtgcag ataacggggg acgaggagga ggaggaggac      240

ggaggtgggg ggctggagga ggacgaggag gaggaggaag aggaggagat ggggctggac      300

tgggacgagc ccctggagcc cgaggactcg gccggggagg agctggagcc cgagccggtc      360

catatgatca atatggacca gagcgccgcg ctggagcccg aggcgccgcc gcgactgctg      420

gcgccccggg cccgcggtgg gccgcccggg gacggctccg agctggaccc cgacgtgctg      480

cagcgccccg agcgggcccg gctgagcgag aacacccggc tggccacccg ctacgccgtg      540

cgcatcttcc gggagtacct gagcgagaag gcgcagagcc cggacttcga gaccatggac      600

aagggggcgc tgtgccgcgt gctgcgctcc ttctatgccg aggcccgctc caaaagcggc      660

cagctctaca gcaagtcgtc gctcatcagc atccgcagct ccctcaaccg ctacctcaat      720

gagcccccgt actgccgcac gctcgacctc accaaggacc ccgagctgcg cagcgccaac      780

ctgacgctgg ccgcggtcat ccgcaagctc gaggagcagg gcgccgggcc ggtggtgcag      840

aagcaagcca tcacgcgcgc cgacctgcgc aagctgtaca cctccagcgt cttcagcacc      900

aacacgccct tcgggctgct caacaaggtc tggttcgaga cgtgcatgta cttctgtacc      960

cgcggccgcg agaaccagcg tgagttggag gaggactctt ttgggctggc catggacgag     1020

gacggtcgca agttcgtcta cttcaagtcc ctcgggccct accacaagtc gcgctcgtcg     1080

tcgtggagca agaagcgcgc cgagagcagc gacgaggaga acttgccccg catgtatgag     1140

acgggcaccg agttctgccc ctacgccagc ttcgtcaagt acctgtcgaa acgcaaccct     1200

ctctgcaagg cgttcttcca gcggccccgg gaccactgca gcgagggcga tgtgacctgg     1260

tacgagaaca aagccatcgg caagaacttg ctaggcactc ggatgcagat gctctccaag     1320

gcggccaagc tctccaagac ctacaccaac cactgcatcg gcgccgtctc catcgccacg     1380

ctcaacagca tcgcgggcat tggcaccaag ctgggctcgc ccgccccgca gggctgctac     1440

gccgaggctc tgaacggggc ggcacggcac cactcccacc acccccccac ccatccctcc     1500

caccaccacc gcccccagcc gccctcgctg gggaacactt acatcctccc caaagacagc     1560

caggtcgggc ccgacgtgaa atccgaggct gcgcccaagc gcgccctgta cgagtctgtg     1620

ttcgggtcgg gggaaatctg cggccccact tcccccaaaa gactttgtat ccgcccctcg     1680

gagcctgtgg atgcggtggt ggtggtttcc gtgaaacacg accccctgcc tcttcttcca     1740

gaagccaatg ggcacagaag caccaattct cccacaatag tttcacctgc tattgtttcc     1800

cccacccagg acagtcggcc caatatgtca agacctctga tcactagatc ccctgcatct     1860

ccactgaaca accaaggcat ccctactcca gcacaactca caaaatccaa tgcgcctgtc     1920

cacattgatg tgggcggcca catgtacacc agcagcctgg ccaccctcac caaataccct     1980

gaatccagaa tcggaagact ttttgatggt acagagccca ttgttttgga cagtctcaaa     2040

cagcactatt tcattgacag agatggacag atgttcagat atatcttgaa ttttctacga     2100

acatccaaac tcctcattcc tgatgatttc aaggactaca ctttgttata tgaagaggca     2160

aaatattttc agcttcagcc catgttgttg gagatggaaa gatggaagca ggacagagaa     2220

actggtcgat tttcaaggcc ctgtgagtgc ctcgtcgtgc gtgtggcccc agacctcgga     2280

gaaaggatca cgctaagcgg tgacaaatcc ttgatagaag aagtatttcc agagatcggc     2340

gacgtgatgt gtaactctgt caatgcaggc tggaatcacg actcgacgca cgtcatcagg     2400

tttccactaa atggctactg tcacctcaac tcagtccagg tcctcgagag gttgcagcaa     2460

agaggatttg aaatcgtggg ctcctgtggg ggaggagtag actcgtccca gttcagcgaa     2520

tacgtccttc ggcgggaact gaggcggacg ccccgtgtac cctccgtcat ccggataaag     2580

caagagcctc tggactaaat ggacatattt cttatgcaaa aaggaaaaca cacacaacca     2640

ataactcaaa caaaaaaggg acatttatgt gcagttggga cagcaaacca agtcctggac     2700

gtaaaatcga ataaaagaca catttatatc caatagagac cacacctgta ttcatatggg     2760

aacaattgga atagtgatat cctcaaggtg taaaaaatat ataaatatat atatatatgt     2820

caaaaggtag gaaatgcaaa aaagaaaaaa aaaaaaggtg acagccgcag ttggtgctgt     2880

gatggccgtg aagtgtcctg ggccttccga ggcctctgac aaataaacaa gccatgagtg     2940

gtgaggacac agtctcctta cagtttccat tgccaacaac agccatccat atttcttttt     3000

tcctttgtct ttctttttcc ttttttttta aaaaaacaaa acaaacaaaa caccttgaat     3060

caagtttgtt tgtatatgga ggttccacgt ctttctttag gcagggacca ggcaggactt     3120

cagaaaaacc ctcatgagca cattgcaaag atgttagaca tgaaatttta aatgtagttt     3180

gtacagaagt cacacttttt tgtccacctc acagatgtga actttacttt gttttaaaac     3240

tgatcagttt tgccaagggg ccagaattat tccttgttag aattgctcca gttcaagtct     3300

gctgctttcc tacaattttt caaattttat aatgtattaa atacaataaa ctctgtttaa     3360

aaaataaggt ctgtgtgaaa cacacatgtg ggggtgaggc tggattaaag tgaaattttt     3420

tctttttgaa aaaaaaaa                                                   3438


<210>  181
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ala Arg Met Pro Gly Ser Gly Asp Cys Asn Thr Ser Ala Gly Gly 
1               5                   10                  15      


Ser Ala Ser Ala Ala Ala Ala Ala Ala Glu Asn Asn Gly Glu Arg Gly 
            20                  25                  30          


Glu Gly Glu Arg Gly Ala Gly Gly Arg Gly Arg Arg His Ser Arg Pro 
        35                  40                  45              


His Tyr Cys Ser Ala Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    50                  55                  60                  


Glu Ile Gln Glu Val Gln Ile Thr Gly Asp Glu Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Gly Gly Gly Gly Leu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Met Gly Leu Asp Trp Asp Glu Pro Leu Glu Pro Glu Asp Ser Ala Gly 
            100                 105                 110         


Glu Glu Leu Glu Pro Glu Pro Val His Met Ile Asn Met Asp Gln Ser 
        115                 120                 125             


Ala Ala Leu Glu Pro Glu Ala Pro Pro Arg Leu Leu Ala Pro Arg Ala 
    130                 135                 140                 


Arg Gly Gly Pro Pro Gly Asp Gly Ser Glu Leu Asp Pro Asp Val Leu 
145                 150                 155                 160 


Gln Arg Pro Glu Arg Ala Arg Leu Ser Glu Asn Thr Arg Leu Ala Thr 
                165                 170                 175     


Arg Tyr Ala Val Arg Ile Phe Arg Glu Tyr Leu Ser Glu Lys Ala Gln 
            180                 185                 190         


Ser Pro Asp Phe Glu Thr Met Asp Lys Gly Ala Leu Cys Arg Val Leu 
        195                 200                 205             


Arg Ser Phe Tyr Ala Glu Ala Arg Ser Lys Ser Gly Gln Leu Tyr Ser 
    210                 215                 220                 


Lys Ser Ser Leu Ile Ser Ile Arg Ser Ser Leu Asn Arg Tyr Leu Asn 
225                 230                 235                 240 


Glu Pro Pro Tyr Cys Arg Thr Leu Asp Leu Thr Lys Asp Pro Glu Leu 
                245                 250                 255     


Arg Ser Ala Asn Leu Thr Leu Ala Ala Val Ile Arg Lys Leu Glu Glu 
            260                 265                 270         


Gln Gly Ala Gly Pro Val Val Gln Lys Gln Ala Ile Thr Arg Ala Asp 
        275                 280                 285             


Leu Arg Lys Leu Tyr Thr Ser Ser Val Phe Ser Thr Asn Thr Pro Phe 
    290                 295                 300                 


Gly Leu Leu Asn Lys Val Trp Phe Glu Thr Cys Met Tyr Phe Cys Thr 
305                 310                 315                 320 


Arg Gly Arg Glu Asn Gln Arg Glu Leu Glu Glu Asp Ser Phe Gly Leu 
                325                 330                 335     


Ala Met Asp Glu Asp Gly Arg Lys Phe Val Tyr Phe Lys Ser Leu Gly 
            340                 345                 350         


Pro Tyr His Lys Ser Arg Ser Ser Ser Trp Ser Lys Lys Arg Ala Glu 
        355                 360                 365             


Ser Ser Asp Glu Glu Asn Leu Pro Arg Met Tyr Glu Thr Gly Thr Glu 
    370                 375                 380                 


Phe Cys Pro Tyr Ala Ser Phe Val Lys Tyr Leu Ser Lys Arg Asn Pro 
385                 390                 395                 400 


Leu Cys Lys Ala Phe Phe Gln Arg Pro Arg Asp His Cys Ser Glu Gly 
                405                 410                 415     


Asp Val Thr Trp Tyr Glu Asn Lys Ala Ile Gly Lys Asn Leu Leu Gly 
            420                 425                 430         


Thr Arg Met Gln Met Leu Ser Lys Ala Ala Lys Leu Ser Lys Thr Tyr 
        435                 440                 445             


Thr Asn His Cys Ile Gly Ala Val Ser Ile Ala Thr Leu Asn Ser Ile 
    450                 455                 460                 


Ala Gly Ile Gly Thr Lys Leu Gly Ser Pro Ala Pro Gln Gly Cys Tyr 
465                 470                 475                 480 


Ala Glu Ala Leu Asn Gly Ala Ala Arg His His Ser His His Pro Pro 
                485                 490                 495     


Thr His Pro Ser His His His Arg Pro Gln Pro Pro Ser Leu Gly Asn 
            500                 505                 510         


Thr Tyr Ile Leu Pro Lys Asp Ser Gln Val Gly Pro Asp Val Lys Ser 
        515                 520                 525             


Glu Ala Ala Pro Lys Arg Ala Leu Tyr Glu Ser Val Phe Gly Ser Gly 
    530                 535                 540                 


Glu Ile Cys Gly Pro Thr Ser Pro Lys Arg Leu Cys Ile Arg Pro Ser 
545                 550                 555                 560 


Glu Pro Val Asp Ala Val Val Val Val Ser Val Lys His Asp Pro Leu 
                565                 570                 575     


Pro Leu Leu Pro Glu Ala Asn Gly His Arg Ser Thr Asn Ser Pro Thr 
            580                 585                 590         


Ile Val Ser Pro Ala Ile Val Ser Pro Thr Gln Asp Ser Arg Pro Asn 
        595                 600                 605             


Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro Leu Asn Asn 
    610                 615                 620                 


Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn Ala Pro Val 
625                 630                 635                 640 


His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu Ala Thr Leu 
                645                 650                 655     


Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp Gly Thr Glu 
            660                 665                 670         


Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile Asp Arg Asp 
        675                 680                 685             


Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr Ser Lys Leu 
    690                 695                 700                 


Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala 
705                 710                 715                 720 


Lys Tyr Phe Gln Leu Gln Pro Met Leu Leu Glu Met Glu Arg Trp Lys 
                725                 730                 735     


Gln Asp Arg Glu Thr Gly Arg Phe Ser Arg Pro Cys Glu Cys Leu Val 
            740                 745                 750         


Val Arg Val Ala Pro Asp Leu Gly Glu Arg Ile Thr Leu Ser Gly Asp 
        755                 760                 765             


Lys Ser Leu Ile Glu Glu Val Phe Pro Glu Ile Gly Asp Val Met Cys 
    770                 775                 780                 


Asn Ser Val Asn Ala Gly Trp Asn His Asp Ser Thr His Val Ile Arg 
785                 790                 795                 800 


Phe Pro Leu Asn Gly Tyr Cys His Leu Asn Ser Val Gln Val Leu Glu 
                805                 810                 815     


Arg Leu Gln Gln Arg Gly Phe Glu Ile Val Gly Ser Cys Gly Gly Gly 
            820                 825                 830         


Val Asp Ser Ser Gln Phe Ser Glu Tyr Val Leu Arg Arg Glu Leu Arg 
        835                 840                 845             


Arg Thr Pro Arg Val Pro Ser Val Ile Arg Ile Lys Gln Glu Pro Leu 
    850                 855                 860                 


Asp 
865 


<210>  182
<211>  1754
<212>  DNA
<213>  Homo sapiens

<400>  182
ccaccacctg cctcaccagt agctgggact acagctcccg tcactagctt tttctcctca       60

agcctgcact gcacaccaac tgggacggag ggtgcagatg aataaaggca aatccatcac      120

caaaagacag tcggcccaat atgtcaagac ctctgatcac tagatcccct gcatctccac      180

tgaacaacca aggcatccct actccagcac aactcacaaa atccaatgcg cctgtccaca      240

ttgatgtggg cggccacatg tacaccagca gcctggccac cctcaccaaa taccctgaat      300

ccagaatcgg aagacttttt gatggtacag agcccattgt tttggacagt ctcaaacagc      360

actatttcat tgacagagat ggacagatgt tcagatatat cttgaatttt ctacgaacat      420

ccaaactcct cattcctgat gatttcaagg actacacttt gttatatgaa gaggcaaaat      480

attttcagct tcagcccatg ttgttggaga tggaaagatg gaagcaggac agagaaactg      540

gtcgattttc aaggccctgt gagtgcctcg tcgtgcgtgt ggccccagac ctcggagaaa      600

ggatcacgct aagcggtgac aaatccttga tagaagaagt atttccagag atcggcgacg      660

tgatgtgtaa ctctgtcaat gcaggctgga atcacgactc gacgcacgtc atcaggtttc      720

cactaaatgg ctactgtcac ctcaactcag tccaggtcct cgagaggttg cagcaaagag      780

gatttgaaat cgtgggctcc tgtgggggag gagtagactc gtcccagttc agcgaatacg      840

tccttcggcg ggaactgagg cggacgcccc gtgtaccctc cgtcatccgg ataaagcaag      900

agcctctgga ctaaatggac atatttctta tgcaaaaagg aaaacacaca caaccaataa      960

ctcaaacaaa aaagggacat ttatgtgcag ttgggacagc aaaccaagtc ctggacgtaa     1020

aatcgaataa aagacacatt tatatccaat agagaccaca cctgtattca tatgggaaca     1080

attggaatag tgatatcctc aaggtgtaaa aaatatataa atatatatat atatgtcaaa     1140

aggtaggaaa tgcaaaaaag aaaaaaaaaa aaggtgacag ccgcagttgg tgctgtgatg     1200

gccgtgaagt gtcctgggcc ttccgaggcc tctgacaaat aaacaagcca tgagtggtga     1260

ggacacagtc tccttacagt ttccattgcc aacaacagcc atccatattt cttttttcct     1320

ttgtctttct ttttcctttt tttttaaaaa aacaaaacaa acaaaacacc ttgaatcaag     1380

tttgtttgta tatggaggtt ccacgtcttt ctttaggcag ggaccaggca ggacttcaga     1440

aaaaccctca tgagcacatt gcaaagatgt tagacatgaa attttaaatg tagtttgtac     1500

agaagtcaca cttttttgtc cacctcacag atgtgaactt tactttgttt taaaactgat     1560

cagttttgcc aaggggccag aattattcct tgttagaatt gctccagttc aagtctgctg     1620

ctttcctaca atttttcaaa ttttataatg tattaaatac aataaactct gtttaaaaaa     1680

taaggtctgt gtgaaacaca catgtggggg tgaggctgga ttaaagtgaa attttttctt     1740

tttgaaaaaa aaaa                                                       1754


<210>  183
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro Leu Asn Asn 
1               5                   10                  15      


Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn Ala Pro Val 
            20                  25                  30          


His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu Ala Thr Leu 
        35                  40                  45              


Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp Gly Thr Glu 
    50                  55                  60                  


Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile Asp Arg Asp 
65                  70                  75                  80  


Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr Ser Lys Leu 
                85                  90                  95      


Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala 
            100                 105                 110         


Lys Tyr Phe Gln Leu Gln Pro Met Leu Leu Glu Met Glu Arg Trp Lys 
        115                 120                 125             


Gln Asp Arg Glu Thr Gly Arg Phe Ser Arg Pro Cys Glu Cys Leu Val 
    130                 135                 140                 


Val Arg Val Ala Pro Asp Leu Gly Glu Arg Ile Thr Leu Ser Gly Asp 
145                 150                 155                 160 


Lys Ser Leu Ile Glu Glu Val Phe Pro Glu Ile Gly Asp Val Met Cys 
                165                 170                 175     


Asn Ser Val Asn Ala Gly Trp Asn His Asp Ser Thr His Val Ile Arg 
            180                 185                 190         


Phe Pro Leu Asn Gly Tyr Cys His Leu Asn Ser Val Gln Val Leu Glu 
        195                 200                 205             


Arg Leu Gln Gln Arg Gly Phe Glu Ile Val Gly Ser Cys Gly Gly Gly 
    210                 215                 220                 


Val Asp Ser Ser Gln Phe Ser Glu Tyr Val Leu Arg Arg Glu Leu Arg 
225                 230                 235                 240 


Arg Thr Pro Arg Val Pro Ser Val Ile Arg Ile Lys Gln Glu Pro Leu 
                245                 250                 255     


Asp 
    


<210>  184
<211>  7080
<212>  DNA
<213>  Homo sapiens

<400>  184
gagctagcgc tcaagcagag cccagcgcgg tgctatcgga cagagcctgg cgagcgcaag       60

cggcgcgggg agccagcggg gctgagcgcg gccagggtct gaacccagat ttcccagact      120

agctaccact ccgcttgccc acgccccggg agctcgcggc gcctggcggt cagcgaccag      180

acgtccgggg ccgctgcgct cctggcccgc gaggcgtgac actgtctcgg ctacagaccc      240

agagggagca cactgccagg atgggagctg ctgggaggca ggacttcctc ttcaaggcca      300

tgctgaccat cagctggctc actctgacct gcttccctgg ggccacatcc acagtggctg      360

ctgggtgccc tgaccagagc cctgagttgc aaccctggaa ccctggccat gaccaagacc      420

accatgtgca tatcggccag ggcaagacac tgctgctcac ctcttctgcc acggtctatt      480

ccatccacat ctcagaggga ggcaagctgg tcattaaaga ccacgacgag ccgattgttt      540

tgcgaacccg gcacatcctg attgacaacg gaggagagct gcatgctggg agtgccctct      600

gccctttcca gggcaatttc accatcattt tgtatggaag ggctgatgaa ggtattcagc      660

cggatcctta ctatggtctg aagtacattg gggttggtaa aggaggcgct cttgagttgc      720

atggacagaa aaagctctcc tggacatttc tgaacaagac ccttcaccca ggtggcatgg      780

cagaaggagg ctattttttt gaaaggagct ggggccaccg tggagttatt gttcatgtca      840

tcgaccccaa atcaggcaca gtcatccatt ctgaccggtt tgacacctat agatccaaga      900

aagagagtga acgtctggtc cagtatttga acgcggtgcc cgatggcagg atcctttctg      960

ttgcagtgaa tgatgaaggt tctcgaaatc tggatgacat ggccaggaag gcgatgacca     1020

aattgggaag caaacacttc ctgcaccttg gatttagaca cccttggagt tttctaactg     1080

tgaaaggaaa tccatcatct tcagtggaag accatattga atatcatgga catcgaggct     1140

ctgctgctgc ccgggtattc aaattgttcc agacagagca tggcgaatat ttcaatgttt     1200

ctttgtccag tgagtgggtt caagacgtgg agtggacgga gtggttcgat catgataaag     1260

tatctcagac taaaggtggg gagaaaattt cagacctctg gaaagctcac ccaggaaaaa     1320

tatgcaatcg tcccattgat atacaggcca ctacaatgga tggagttaac ctcagcaccg     1380

aggttgtcta caaaaaaggc caggattata ggtttgcttg ctacgaccgg ggcagagcct     1440

gccggagcta ccgtgtacgg ttcctctgtg ggaagcctgt gaggcccaaa ctcacagtca     1500

ccattgacac caatgtgaac agcaccattc tgaacttgga ggataatgta cagtcatgga     1560

aacctggaga taccctggtc attgccagta ctgattactc catgtaccag gcagaagagt     1620

tccaggtgct tccctgcaga tcctgcgccc ccaaccaggt caaagtggca gggaaaccaa     1680

tgtacctgca catcggggag gagatagacg gcgtggacat gcgggcggag gttgggcttc     1740

tgagccggaa catcatagtg atgggggaga tggaggacaa atgctacccc tacagaaacc     1800

acatctgcaa tttctttgac ttcgatacct ttgggggcca catcaagttt gctctgggat     1860

ttaaggcagc acacttggag ggcacggagc tgaagcatat gggacagcag ctggtgggtc     1920

agtacccgat tcacttccac ctggccggtg atgtagacga aaggggaggt tatgacccac     1980

ccacatacat cagggacctc tccatccatc atacattctc tcgctgcgtc acagtccatg     2040

gctccaatgg cttgttgatc aaggacgttg tgggctataa ctctttgggc cactgcttct     2100

tcacggaaga tgggccggag gaacgcaaca cttttgacca ctgtcttggc ctccttgtca     2160

agtctggaac cctcctcccc tcggaccgtg acagcaagat gtgcaagatg atcacagagg     2220

actcctaccc ggggtacatc cccaagccca ggcaagactg caatgctgtg tccaccttct     2280

ggatggccaa tcccaacaac aacctcatca actgtgccgc tgcaggatct gaggaaactg     2340

gattttggtt tatttttcac cacgtaccaa cgggcccctc cgtgggaatg tactccccag     2400

gttattcaga gcacattcca ctgggaaaat tctataacaa ccgagcacat tccaactacc     2460

gggctggcat gatcatagac aacggagtca aaaccaccga ggcctctgcc aaggacaagc     2520

ggccgttcct ctcaatcatc tctgccagat acagccctca ccaggacgcc gacccgctga     2580

agccccggga gccggccatc atcagacact tcattgccta caagaaccag gaccacgggg     2640

cctggctgcg cggcggggat gtgtggctgg acagctgccg gtttgctgac aatggcattg     2700

gcctgaccct ggccagtggt ggaaccttcc cgtatgacga cggctccaag caagagataa     2760

agaacagctt gtttgttggc gagagtggca acgtggggac ggaaatgatg gacaatagga     2820

tctggggccc tggcggcttg gaccatagcg gaaggaccct ccctataggc cagaattttc     2880

caattagagg aattcagtta tatgatggcc ccatcaacat ccaaaactgc actttccgaa     2940

agtttgtggc cctggagggc cggcacacca gcgccctggc cttccgcctg aataatgcct     3000

ggcagagctg cccccataac aacgtgaccg gcattgcctt tgaggacgtt ccgattactt     3060

ccagagtgtt cttcggagag cctgggccct ggttcaacca gctggacatg gatggggata     3120

agacatctgt gttccatgac gtcgacggct ccgtgtccga gtaccctggc tcctacctca     3180

cgaagaatga caactggctg gtccggcacc cagactgcat caatgttccc gactggagag     3240

gggccatttg cagtgggtgc tatgcacaga tgtacattca agcctacaag accagtaacc     3300

tgcgaatgaa gatcatcaag aatgacttcc ccagccaccc tctttacctg gagggggcgc     3360

tcaccaggag cacccattac cagcaatacc aaccggttgt caccctgcag aagggctaca     3420

ccatccactg ggaccagacg gcccccgccg aactcgccat ctggctcatc aacttcaaca     3480

agggcgactg gatccgagtg gggctctgct acccgcgagg caccacattc tccatcctct     3540

cggatgttca caatcgcctg ctgaagcaaa cgtccaagac gggcgtcttc gtgaggacct     3600

tgcagatgga caaagtggag cagagctacc ctggcaggag ccactactac tgggacgagg     3660

actcagggct gttgttcctg aagctgaaag ctcagaacga gagagagaag tttgctttct     3720

gctccatgaa aggctgtgag aggataaaga ttaaagctct gattccaaag aacgcaggcg     3780

tcagtgactg cacagccaca gcttacccca agttcaccga gagggctgtc gtagacgtgc     3840

cgatgcccaa gaagctcttt ggttctcagc tgaaaacaaa ggaccatttc ttggaggtga     3900

agatggagag ttccaagcag cacttcttcc acctctggaa cgacttcgct tacattgaag     3960

tggatgggaa gaagtacccc agttcggagg atggcatcca ggtggtggtg attgacggga     4020

accaagggcg cgtggtgagc cacacgagct tcaggaactc cattctgcaa ggcataccat     4080

ggcagctttt caactatgtg gcgaccatcc ctgacaattc catagtgctt atggcatcaa     4140

agggaagata cgtctccaga ggcccatgga ccagagtgct ggaaaagctt ggggcagaca     4200

ggggtctcaa gttgaaagag caaatggcat tcgttggctt caaaggcagc ttccggccca     4260

tctgggtgac actggacact gaggatcaca aagccaaaat cttccaagtt gtgcccatcc     4320

ctgtggtgaa gaagaagaag ttgtgaggac agctgccgcc cggtgccacc tcgtggtaga     4380

ctatgacggt gactcttggc agcagaccag tgggggatgg ctgggtcccc cagcccctgc     4440

cagcagctgc ctgggaaggc cgtgtttcag ccctgatggg ccaagggaag gctatcagag     4500

accctggtgc tgccacctgc ccctactcaa gtgtctacct ggagcccctg gggcggtgct     4560

ggccaatgct ggaaacattc actttcctgc agcctcttgg gtgcttctct cctatctgtg     4620

cctcttcagt gggggtttgg ggaccatatc aggagacctg ggttgtgctg acagcaaaga     4680

tccactttgg caggagccct gacccagcta ggaggtagtc tggagggctg gtcattcaca     4740

gatccccatg gtcttcagca gacaagtgag ggtggtaaat gtaggagaaa gagccttggc     4800

cttaaggaaa tctttactcc tgtaagcaag agccaacctc acaggattag gagctggggt     4860

agaactggct atccttgggg aagaggcaag ccctgcctct ggccgtgtcc acctttcagg     4920

agactttgag tggcaggttt ggacttggac tagatgactc tcaaaggccc ttttagttct     4980

gagattccag aaatctgctg catttcacat ggtacctgga acccaacagt tcatggatat     5040

ccactgatat ccatgatgct gggtgcccca gcgcacacgg gatggagagg tgagaactaa     5100

tgcctagctt gaggggtctg cagtccagta gggcaggcag tcaggtccat gtgcactgca     5160

atgccaggtg gagaaatcac agagaggtaa aatggaggcc agtgccattt cagaggggag     5220

gctcaggaag gcttcttgct tacaggaatg aaggctgggg gcattttgct ggggggagat     5280

gaggcagcct ctggaatggc tcagggattc agccctccct gccgctgcct gctgaagctg     5340

gtgactacgg ggtcgccctt tgctcacgtc tctctggccc actcatgatg gagaagtgtg     5400

gtcagagggg agcaatgggc tttgctgctt atgagcacag aggaattcag tccccaggca     5460

gccctgcctc tgactccaag agggtgaagt ccacagaagt gagctcctgc cttagggcct     5520

catttgctct tcatccaggg aactgagcac agggggcctc caggagaccc tagatgtgct     5580

cgtactccct cggcctggga tttcagagct ggaaatatag aaaatatcta gcccaaagcc     5640

ttcattttaa cagatgggga aagtgagccc ccaagatggg aaagaaccac acagctaagg     5700

gagggcctgg ggagccccac cctagccctt gctgccacac cacattgcct caacaaccgg     5760

ccccagagtg cccaggcact cctgaggtag cttctggaaa tggggacaag tcccctcgaa     5820

ggaaaggaaa tgactagagt agaatgacag ctagcagatc tcttccctcc tgctcccagc     5880

gcacacaaac ccgccctccc cttggtgttg gcggtccctg tggccttcac tttgttcact     5940

acctgtcagc ccagcctggg tgcacagtag ctgcaactcc ccattggtgc tacctggctc     6000

tcctgtctct gcagctctac aggtgaggcc cagcagaggg agtagggctc gccatgtttc     6060

tggtgagcca atttggctga tcttgggtgt ctgaacagct attgggtcca ccccagtccc     6120

tttcagctgc tgcttaatgc cctgctctct ccctggccca ccttatagag agcccaaaga     6180

gctcctgtaa gagggagaac tctatctgtg gtttataatc ttgcacgagg caccagagtc     6240

tccctgggtc ttgtgatgaa ctacatttat cccctttcct gccccaacca caaactcttt     6300

ccttcaaaga gggcctgcct ggctccctcc acccaactgc acccatgaga ctcggtccaa     6360

gagtccattc cccaggtggg agccaactgt cagggaggtc tttcccacca aacatctttc     6420

agctgctggg aggtgaccat agggctctgc ttttaaagat atggctgctt caaaggccag     6480

agtcacagga aggacttctt ccagggagat tagtggtgat ggagaggaga gttaaaatga     6540

cctcatgtcc ttcttgtcca cggttttgtt gagttttcac tcttctaatg caagggtctc     6600

acactgtgaa ccacttagga tgtgatcact ttcaggtggc caggaatgtt gaatgtcttt     6660

ggctcagttc atttaaaaaa gatatctatt tgaaagttct cagagttgta catatgtttc     6720

acagtacagg atctgtacat aaaagtttct ttcctaaacc attcaccaag agccaatatc     6780

taggcatttt cttggtagca caaattttct tattgcttag aaaattgtcc tccttgttat     6840

ttctgtttgt aagacttaag tgagttaggt ctttaaggaa agcaacgctc ctctgaaatg     6900

cttgtctttt ttctgttgcc gaaatagctg gtcctttttc gggagttaga tgtatagagt     6960

gtttgtatgt aaacatttct tgtaggcatc accatgaaca aagatatatt ttctatttat     7020

ttattatatg tgcacttcaa gaagtcactg tcagagaaat aaagaattgt cttaaatgtc     7080


<210>  185
<211>  1361
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  186
<211>  1315
<212>  DNA
<213>  Homo sapiens

<400>  186
gcagttcttt gaatttctca ccctaagatc tggcctgtac attttcaagg aattcttgag       60

aggttcttgg agagattctg ggagccaaac actccattgg gatcctagct gttttagaga      120

acaacttgta atggagcctt catctcttga gctgccggct gacacagtgc agcgcattgc      180

ggctgaactc aaatgccacc caacggatga gagggtggct ctccacctag atgaggaaga      240

taagctgagg cacttcaggg agtgctttta tattcccaaa atacaggatc tgcctccagt      300

tgatttatca ttagtgaata aagatgaaaa tgccatctat ttcttgggaa attctcttgg      360

ccttcaacca aaaatggtta aaacatatct tgaagaagaa ctagataagt gggccaaaat      420

agcagcctat ggtcatgaag tggggaagcg tccttggatt acaggagatg agagtattgt      480

aggccttatg aaggacattg taggagccaa tgagaaagaa atagccctaa tgaatgcttt      540

gactgtaaat ttacatcttc taatgttatc attttttaag cctacgccaa aacgatataa      600

aattcttcta gaagccaaag ccttcccttc tgatcattat gctattgagt cacaactaca      660

acttcacgga cttaacattg aagaaagtat gcggatgata aagccaagag agggggaaga      720

aaccttaaga atagaggata tccttgaagt aattgagaag gaaggagact caattgcagt      780

gatcctgttc agtggggtgc atttttacac tggacagcac tttaatattc ctgccatcac      840

aaaagctgga caagcgaagg gttgttatgt tggctttgat ctagcacatg cagttggaaa      900

tgttgaactc tacttacatg actggggagt tgattttgcc tgctggtgtt cctacaagta      960

tttaaatgca ggagcaggag gaattgctgg tgccttcatt catgaaaagc atgcccatac     1020

gattaaacct gcgagatcgg agttctttaa ttaggaatgg aatgcaacag atttggacaa     1080

gtcaaggaca agagctttag agagaccaaa gagtttttca ctgttaaagt gtccagtatg     1140

tagccgagaa ccatatggag aacatcaaat acagtggaac aaatgtaact gctattgatg     1200

tcacactttg tgaagtagtc tttgttgctt aaaaagggtg acatctagtg gctaaacatg     1260

ttatttcaaa taaataatat cgaaataaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1315


<210>  187
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Arg Ser Glu 
    290                 295                 300                 


Phe Phe Asn 
305         


<210>  188
<211>  1688
<212>  DNA
<213>  Homo sapiens

<400>  188
gcagttcttt gaatttctca ccctaagatc tggcctgtac attttcaagg aattcttgag       60

aggttcttgg agagattctg ggagccaaac actccattgg gatcctagct gttttagaga      120

acaacttgta atggagcctt catctcttga gctgccggct gacacagtgc agcgcattgc      180

ggctgaactc aaatgccacc caacggatga gagggtggct ctccacctag atgaggaaga      240

taagctgagg cacttcaggg agtgctttta tattcccaaa atacaggatc tgcctccagt      300

tgatttatca ttagtgaata aagatgaaaa tgccatctat ttcttgggaa attctcttgg      360

ccttcaacca aaaatggtta aaacatatct tgaagaagaa ctagataagt gggccaaaat      420

agcagcctat ggtcatgaag tggggaagcg tccttggatt acaggagatg agagtattgt      480

aggccttatg aaggacattg taggagccaa tgagaaagaa atagccctaa tgaatgcttt      540

gactgtaaat ttacatcttc taatgttatc attttttaag cctacgccaa aacgatataa      600

aattcttcta gaagccaaag ccttcccttc tgatcattat gctattgagt cacaactaca      660

acttcacgga cttaacattg aagaaagtat gcggatgata aagccaagag agggggaaga      720

aaccttaaga atagaggata tccttgaagt aattgagaag gaaggagact caattgcagt      780

gatcctgttc agtggggtgc atttttacac tggacagcac tttaatattc ctgccatcac      840

aaaagctgga caagcgaagg gttgttatgt tggctttgat ctagcacatg cagttggaaa      900

tgttgaactc tacttacatg actggggagt tgattttgcc tgctggtgtt cctacaagta      960

tttaaatgca ggagcaggag gaattgctgg tgccttcatt catgaaaagc atgcccatac     1020

gattaaacct gcattagtgg gatggtttgg ccatgaactc agcaccagat ttaagatgga     1080

taacaaactg cagttaatcc ctggggtctg tggattccga atttcaaatc ctcccatttt     1140

gttggtctgt tccttgcatg ctagtttaga gatctttaag caagcgacaa tgaaggcatt     1200

gcggaaaaaa tctgttttgc taactggcta tctggaatac ctgatcaagc ataactatgg     1260

caaagataaa gcagcaacca agaaaccagt tgtgaacata attactccgt ctcatgtaga     1320

ggagcggggg tgccagctaa caataacatt ttctgttcca aacaaagatg ttttccaaga     1380

actagaaaaa agaggagtgg tttgtgacaa gcggaatcca aatggcattc gagtggctcc     1440

agttcctctc tataattctt tccatgatgt ttataaattt accaatctgc tcacttctat     1500

acttgactct gcagaaacaa aaaattagca gtgttttcta gaacaactta agcaaattat     1560

actgaaagct gctgtggtta tttcagtatt attcgatttt taattattga aagtatgtca     1620

ccattgacca catgtaacta acaataaata atatacctta cagaaaatct gaaaaaaaaa     1680

aaaaaaaa                                                              1688


<210>  189
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly 
    290                 295                 300                 


Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu 
305                 310                 315                 320 


Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile 
                325                 330                 335     


Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala 
            340                 345                 350         


Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu 
        355                 360                 365             


Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys 
    370                 375                 380                 


Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly 
385                 390                 395                 400 


Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln 
                405                 410                 415     


Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly 
            420                 425                 430         


Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr 
        435                 440                 445             


Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys 
    450                 455                 460                 


Asn 
465 


<210>  190
<211>  5783
<212>  DNA
<213>  Homo sapiens

<400>  190
gcgtcccatg gatatagcaa caggtcccga gtcgctggag aggtgcttcc ctcgcgggca       60

gacggactgc gccaagatgt tggacggcat caagatggag gagcacgccc tgcgccccgg      120

gcccgccact ctgggggtgc tgctgggctc cgactgcccg catcccgccg tctgcgaggg      180

ctgccagcgg cccatctccg accgcttcct gatgcgagtc aacgagtcgt cctggcacga      240

ggagtgtttg cagtgcgcgg cgtgtcagca agccctcacc accagctgct acttccggga      300

tcggaaactg tactgcaaac aagactacca acagctcttc gcggccaagt gcagcggctg      360

catggagaag atcgccccca ccgagttcgt gatgcgggcg ctggagtgcg tgtaccacct      420

gggctgcttc tgctgctgcg tgtgtgaacg gcagctacgc aagggcgacg aattcgtgct      480

caaggagggc cagctgctgt gcaagggtga ctacgagaag gagaaggacc tgctcagctc      540

cgtgagcccc gacgagtccg actccgtgaa gagcgaggat gaagatgggg acatgaagcc      600

ggccaagggg cagggcagtc agagcaaggg cagcggggat gacgggaagg acccgcggag      660

gcccaagcga ccccggacca tcctcaccac gcagcagcga agagccttca aggcctcctt      720

cgaggtctcg tcgaagcctt gccgaaaggt ccgagagaca ctggcagctg agacgggcct      780

cagtgtgcgc gtggtccagg tctggtttca gaaccaaaga gcaaagatga agaagctggc      840

gcggcggcac cagcagcagc aggagcagca gaactcccag cggctgggcc aggaggtcct      900

gtccagccgc atggagggca tgatggcttc ctacacgccg ctggccccac cacagcagca      960

gatcgtggcc atggaacaga gcccctacgg cagcagcgac cccttccagc agggcctcac     1020

gccgccccaa atgccaggga acgactccat cttccatgac atcgacagcg atacctcctt     1080

aaccagcctc agcgactgct tcctcggctc ctcagacgtg ggctccctgc aggcccgcgt     1140

ggggaacccc atcgaccggc tctactccat gcagagttcc tacttcgcct cctgagagcc     1200

agccaggcgc acggacgctt gggcaggggc ctggggggga ctgccagcct ctgcggccag     1260

cctggccacc cccgccctgc tctccgcaca gactacagac agccatacgg tgccctcccc     1320

tcggccagct gggcctgacc actgtgcccg ttgggtacag ccagaccggt agatgggcac     1380

agcctgggca ggggctgtgt cctgcccaca gagaccttgt catccccagg gacccagagc     1440

tctcggacgg ccactcgcct cccagcccca cctcggcctc catcgcctcc tccccatctc     1500

ttttttggga agcttaaatt ctctctattt ttttaaatgt cctctctgtg tccatggccc     1560

tccatgcaag ccccaggaca atggtgtcat gaggcggtga cctgagaagc gtgtgtacct     1620

gtgccccagc aagggcaggg gtggcctctg ggggcaggcc cactgcctgg aaccgcacac     1680

ccctcagcct gagtctggag cagcagtgga gaggggcctg aggggaggca ctgtcaggag     1740

gcgggctcgg agcctgagcc tgggcaggcg caaagggaca gagaggcacg tgcagacaca     1800

tgcacacttg cagacaaacc cacgcaaaca cacacacagc tgtatgggga caccagaagg     1860

gacagggatg ctcagcgggt ctgtcctgcc ttgtcagaaa gagaaaagga ggccaggcag     1920

gggacccccc agttcttaag agcgattgga aagggaggaa ggggagagga agaggcgaac     1980

ttgaagcatc ggacccagtt gtatcccagc ctgggcccaa atgggggcag cctgggcagg     2040

gagggcagcc ccaggcccca ccaactctag aggcagatgg agcccccaga accaggtagc     2100

atcagaccag acaacagagc ctccaggggt cagggacttc agaagcacct gctgggcacc     2160

ccatctgcaa tgtggtcctc tccccagcca cctctgcctc ccctcacata cctccagtga     2220

caaggagctc actaggtcag cgagcccaca gcagctgtgc tgtcctgcat cccagagcca     2280

ggcttcccca gctctccctc ttaacactgt cccccagcag gcctccggct gtccctctaa     2340

aggtgtgggg caggtatcac ttcaccttcc cactgatgtc agccggccag aagtgagcag     2400

gcacatcacc tctcctgctg tggcaccctt cctctgttaa tttggcccaa aagacaatga     2460

tttggccaca tgaccttaga gattcaccct gccctgctgt agctaaatcc ctgggcccca     2520

cacgcaagtg acagctaagc cacatctgtt ttctgtgtat atgcaggatg ggggcaccta     2580

ctgttttgtt ttgttttgtt ttgttttgtt ttgttttgtt ttgttttgtt ttgtttgaga     2640

cggagtttcg ctcttgttgc ccaggctgga gtgcaatggc gcgatctcgg ctcaccacaa     2700

cctccgcctc ccaggttcaa gtgattctga tgcctcagcc tccctagtag ctgagattac     2760

aggcatgcgc caccacaccc agctaatttt gtatttttag tagcaacggg gtttctccat     2820

gttggtcagg ctggtctcca acccccgacc tcaggtgatc cgcctgcctc ggcctcccaa     2880

agtgctggga ttacaggcgt gagccaccgc acccagtctg cacttactgt ttagactgaa     2940

tgagggaccg tgacctcttt ccttttccat tccttcttac tcgattcatt ccagcctgtg     3000

gaatttctct gcaccctgat tcagtgacca ctgctctcct ctctcccagc acatctgccc     3060

agtgaggagt tggccctggg tctcacctga ggtgtgtgga ccgggctggc ctctccctgt     3120

ttgacattgg cccattaatg catcctcttt gggggacaca ttccaattgc atttcctgcc     3180

cccttctccc agggcaattg cagaagattg tgtcaggcgc cctgctggaa gtcaggtgca     3240

ctagatccat ccccagcccc agtctgctca actctatccc tgtcagagca aggaggctgg     3300

gctgctgggg cctgactggt gagcccaccc tgtcccctgg tgatcactgt gtccccttgt     3360

tcaggtgctc acaaccctac ctttaactct gaggtcaagc cctaggccac caccctaaag     3420

tctgcctggt ccaacctttg agcaagtaag gataatgaat gtcccttttc cacctttggg     3480

gccctctgcc tggatctctg gaatcctcta agttcaacct gttctgtggt tttgctcccg     3540

tttgctggga aattcagtcc ccccagaatg tcctgggcca acctccttgc ctgacatgtg     3600

gcctcgtgtc acccattggg ccccagcagc cagctagccc ttctgcagct cttcttacaa     3660

acagagcctc tccaaggacc tcagttgatg ttctggtcct tctgccgcct cagcccacca     3720

gggtccgtgc caccatgggt ctcttgagca gcagctgcac tggcttctgg agagacaccc     3780

ctctttctcc ttttgcacat gcaccatctg aatcgtgcca gggacatcct gggcagattc     3840

aggggcagat gccctatccc ccaggagacc tggcccttct ctctcagacc caataagttg     3900

gaagggacgt cagaagcggt catctcatct gccccttatt ttatagttgg aaaccctgag     3960

gcaagagagg gaaagaggcc tgtccaaggt ccgggttagt gacagagctg agctgagaac     4020

agggacgttg tgccccactg tcccctgtgg tttgtgaatg acctccaggt cagggggtca     4080

caacttgttc ttagtaaact tgccagctgt tggggtcaca tattcccatt ctggggcctc     4140

acaaaccccc gaatccagcc gggaccccat gccaggagct ggtctaggga cagcatgctt     4200

gtgacccaca gactgttaaa gccagaaggg acctcagaga gtcccttatg ctggaggcgc     4260

cctgtcagcc gtggctaggg gccccttgct ctatgctgtg ccttgctgcc cacaggctcc     4320

cagacaccag tgcccactct gcccagcccc ggactgggtg tggctcgcag atgaacaaga     4380

tgcagggcct gccttgaggg gtgtctccta gaaggaaagc cagactctcc ggcccagcca     4440

gagagtccag acatggcagg gacccgtttc tcagatgagg agcctgaggc tcagagaagg     4500

gaggcgatgt gttcagggcc acccagcaga agcctgtggg gctgggcaac cttctcccac     4560

tttatgggag gagctgcagc cttggctggg agctgggcgg ggagtagcca ggaccacccc     4620

ttgcccgtgc cgtgacatgg aaccttcatc actaaggggg ctggagtggg aagagggaga     4680

taactgtgtg gtctccagag caaaagagaa tgagaggtgg gcagggggag tcttggcaaa     4740

agaccaagtt ccacttccct gctggggaag tcaaggctca gaaagaggaa ataattgccc     4800

caggtaacac agggcagagg agggacaaaa agctgggcat ggccccagcc agagcctcat     4860

ctgcctactc cgtgaagcct cccaggtact ctgctatcct gggaaacgca cagggaggcc     4920

acacagagac actgctcaca agagtcagac caaggtgcca gcacagcctg gaaagagctc     4980

agaaaggggg ttggtgcacg tggctgggca tcttaggagg cttcctgagg gtgggtaaag     5040

gtgggaaggc cctggcgctg catcagatga gcagggcctg gcagggacaa gcctcttctc     5100

ctttgggaag ccctgcagcc tcctagcaag aggctgattc cccactctgc ccccatctga     5160

atgtcctttt catgttgcac gcagggaacc tcaggaagga ggattgcctg atgcctgcct     5220

ggctccatcc ttgagctctg ggcaccacct agggtgaggg agagcctgca gctctggggc     5280

taagtctgcc ctggggggaa agggctccac gctcacacgc acgcgctcgc acacacacac     5340

tcacacctgg acgcacacgg aggcttgcgg acccatactc acaggcacat gtggcctggg     5400

gactggggga gcaggaaaga cccctccaac atttggccct tggaaggcac cattgccaat     5460

gagcctcttt gctggttccc ccgaccccac ctgggggtcc catgggagcc cagcccagcc     5520

aggtgtgggg atgggccacc ggccattcct gttttccttg tacagacaga ttctcactac     5580

ccacccgcca tccccagaca cattttattt aataacttgt cattgttaaa ttatttatta     5640

gcgtttacca caccaccacc cccaccctgc cctccactct caccttccac ctcttcccac     5700

aacagcagaa aatggaaaca acaacaaaaa aagatgagac atcagtatat ttgtaaataa     5760

accgacctgt acactcaaaa aaa                                             5783


<210>  191
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Asp Ile Ala Thr Gly Pro Glu Ser Leu Glu Arg Cys Phe Pro Arg 
1               5                   10                  15      


Gly Gln Thr Asp Cys Ala Lys Met Leu Asp Gly Ile Lys Met Glu Glu 
            20                  25                  30          


His Ala Leu Arg Pro Gly Pro Ala Thr Leu Gly Val Leu Leu Gly Ser 
        35                  40                  45              


Asp Cys Pro His Pro Ala Val Cys Glu Gly Cys Gln Arg Pro Ile Ser 
    50                  55                  60                  


Asp Arg Phe Leu Met Arg Val Asn Glu Ser Ser Trp His Glu Glu Cys 
65                  70                  75                  80  


Leu Gln Cys Ala Ala Cys Gln Gln Ala Leu Thr Thr Ser Cys Tyr Phe 
                85                  90                  95      


Arg Asp Arg Lys Leu Tyr Cys Lys Gln Asp Tyr Gln Gln Leu Phe Ala 
            100                 105                 110         


Ala Lys Cys Ser Gly Cys Met Glu Lys Ile Ala Pro Thr Glu Phe Val 
        115                 120                 125             


Met Arg Ala Leu Glu Cys Val Tyr His Leu Gly Cys Phe Cys Cys Cys 
    130                 135                 140                 


Val Cys Glu Arg Gln Leu Arg Lys Gly Asp Glu Phe Val Leu Lys Glu 
145                 150                 155                 160 


Gly Gln Leu Leu Cys Lys Gly Asp Tyr Glu Lys Glu Lys Asp Leu Leu 
                165                 170                 175     


Ser Ser Val Ser Pro Asp Glu Ser Asp Ser Val Lys Ser Glu Asp Glu 
            180                 185                 190         


Asp Gly Asp Met Lys Pro Ala Lys Gly Gln Gly Ser Gln Ser Lys Gly 
        195                 200                 205             


Ser Gly Asp Asp Gly Lys Asp Pro Arg Arg Pro Lys Arg Pro Arg Thr 
    210                 215                 220                 


Ile Leu Thr Thr Gln Gln Arg Arg Ala Phe Lys Ala Ser Phe Glu Val 
225                 230                 235                 240 


Ser Ser Lys Pro Cys Arg Lys Val Arg Glu Thr Leu Ala Ala Glu Thr 
                245                 250                 255     


Gly Leu Ser Val Arg Val Val Gln Val Trp Phe Gln Asn Gln Arg Ala 
            260                 265                 270         


Lys Met Lys Lys Leu Ala Arg Arg His Gln Gln Gln Gln Glu Gln Gln 
        275                 280                 285             


Asn Ser Gln Arg Leu Gly Gln Glu Val Leu Ser Ser Arg Met Glu Gly 
    290                 295                 300                 


Met Met Ala Ser Tyr Thr Pro Leu Ala Pro Pro Gln Gln Gln Ile Val 
305                 310                 315                 320 


Ala Met Glu Gln Ser Pro Tyr Gly Ser Ser Asp Pro Phe Gln Gln Gly 
                325                 330                 335     


Leu Thr Pro Pro Gln Met Pro Gly Asn Asp Ser Ile Phe His Asp Ile 
            340                 345                 350         


Asp Ser Asp Thr Ser Leu Thr Ser Leu Ser Asp Cys Phe Leu Gly Ser 
        355                 360                 365             


Ser Asp Val Gly Ser Leu Gln Ala Arg Val Gly Asn Pro Ile Asp Arg 
    370                 375                 380                 


Leu Tyr Ser Met Gln Ser Ser Tyr Phe Ala Ser 
385                 390                 395 


<210>  192
<211>  4804
<212>  DNA
<213>  Homo sapiens

<400>  192
aaggcagcag gggcggttga gaagtgaagt cttggccgga gtttgctttt tgccaggaaa       60

tccgcggcgg cggcggcggc ggcggcgatt cctggcggag cggagccggg caggctctcc      120

gctccctcag cgggccgcgg agagcgggag ctggtgccga gcagcggcgc caggagcccg      180

tgcgcggccc gggcagccgc gctttcccaa aaaacacacc ttgactttag tcagatacat      240

cactgtctgt taaaggaaac caagcgtgaa gtggaagtct aacacatgag gatacagaat      300

tgattcaaaa tgggaacaac aagtgatgag atggtgtctg tggaacagac ctcctcctct      360

tctctaaacc ccctgtgttt tgaatgtggc caacagcact ggacaagaga aaaccatttg      420

tacaattacc agaatgaagt ggatgatgac ctagtctgcc atatttgcct tcaacctctg      480

ctgcagccac tagacacacc ctgtggacat acattctgct acaagtgcct cagaaacttt      540

ttacaagaga aagatttctg tccgttggac cggaaaagac ttcattttaa gttgtgcaag      600

aagtctagta ttctagttca taaactccta gacaaattat tagttttatg tccattttct      660

tcagtgtgca aagatgtaat gcaacgttgt gatctggagg cacatctcaa aaacagatgt      720

cctggagctt ctcatcggag agttgccctg gagagaagga aaactagtag aactcaagca      780

gagattgaga atgaaaatgg gcccactcta ctagatcctg caggtacctt atctccagaa      840

gcagactgtt tggggacagg cgcagtgcct gtggagcggc acttgacatc agcgtctctt      900

tccacatgga gtgaggagcc tggccttgac aaccctgcct ttgaggagag cgctggagct      960

gacaccacac aacagccact tagtttacca gaaggagaaa tcaccacgat tgaaattcat     1020

cggtccaatc cttacattca gttaggaatc agcattgtgg gtggcaacga aacacctttg     1080

attaacattg tcatccagga ggtctatcgg gatggggtca ttgccagaga cgggagactt     1140

cttgctggag accagattct tcaggtcaac aactacaata tcagcaatgt gtcccataac     1200

tatgcccgag ctgtcctttc ccagccctgc aacacactgc atcttactgt gcttcgagag     1260

aggcgctttg gcaaccgagc acacaaccat tctgatagta actctccacg agaagagatt     1320

ttccaagtgg ctcttcataa acgggactct ggtgaacagc ttggcattaa attggtgcga     1380

aggacagatg agccaggggt ttttattctt gacctgttgg aaggggggtt ggctgcccag     1440

gacggcaggc taagcagcaa tgaccgagtg ctggccatca atgggcacga cctgaagtat     1500

ggaactccgg agcttgctgc ccagattatt caggccagtg gagagagagt gaatttaaca     1560

attgctagac cagggaaacc ccagcctggt aacaccatta gagaagcagg aaatcatagc     1620

agcagcagcc agcaccacac accaccaccg tattatagca gaccaagctc acataaggat     1680

cttactcagt gtgttacatg ccaagaaaaa cacattactg taaagaagga accacatgaa     1740

tcccttggca tgaccgttgc tgggggcagg ggaagtaaga gtggtgagct gcccatcttt     1800

gtgaccagtg tgccacccca tggctgcctt gcacgagatg gcagaataaa gagaggtgat     1860

gtgttgctaa atatcaacgg cattgatttg accaatttaa gtcacagtga ggcagttgca     1920

atgctgaaag ccagtgccgc gtcccctgct gttgccctta aagcacttga ggtccagatt     1980

gttgaggagg cgactcagaa cgcggaggag cagccgagta ctttcagcga aaatgagtat     2040

gatgccagtt ggtccccatc atgggtcatg tggcttgggc ttcccagcac acttcatagc     2100

tgccacgata tagttttacg aagaagttac ttgggaagtt ggggctttag tatcgttggt     2160

ggatatgaag agaaccacac caatcagcct tttttcatta aaactattgt cttgggaact     2220

cctgcttatt atgatggaag attaaagtgt ggtgacatga ttgtggccgt aaatgggctg     2280

tcaaccgtgg gcatgagcca ctctgcacta gttcccatgt tgaaggagca gaggaacaaa     2340

gtcactctga ccgttatttg ttggcctggc agccttgtat agattttgga aattggtttc     2400

aaatcttgca tcttcctttt ttagattttt gaaagaaaac cctttggttt cattgtgttt     2460

gtggtttagg agctgctgac actgctggta tacacagggc caaaacccac taagattgtc     2520

cgtttatgtt tatttaaatg gtttcctaag ttagttacat ttcttttagc ttggaaacag     2580

tcttccacta acctttgtga gtttatattt tcagaattca gacttagttg ttaaaatgtt     2640

acctatggta atgagcaaag ctcacccaaa ctgtgcccca gatggagtaa agaccttctg     2700

gtgggtcttt gttttcagta actgaatcat agaacgagtt ctgtatccct caggcctgat     2760

gtcagcaaag ccagtaacaa cagcgtgtac tgccactgtc ataaccaata ccatgaatga     2820

atatacttta aattttggtg ataactgttc cccatttttt tttgaaccac agtctcactc     2880

tcacccaggc tggagtgcag tggcacaatc tcagctcact gcaagctccg cctcctgggt     2940

tcacgccatt ctcccacctc agcctcccga gtagctggga ctacaggcgt gtgccaccat     3000

gcccagctaa ttttttgtac ttttagtaga gacggggttt caccgtgtta gccaggatgg     3060

tctcgatctc ctgaccttgt gatctgcccg cctcagcctc ccaaagtgct gggattacag     3120

gtgtgagctg ccgcacccgg ccgttcccat tttttattgg tgccaacatt tcaaaacttc     3180

atactgttta taaactgatt ttctggttta tttctactgt aatctctcaa tattcataga     3240

agatgaagaa ataagtctga caacactaaa gaaatttctt aatatactat tattagaata     3300

gtagaggata aaagataatg ttatccagtt acaaaggaat ttggatgata attataactt     3360

aatgttagag atggtaaagc tgcacttact tgaacagccc aaaagcatta aaaatctatt     3420

tccagaggaa tgttttgcta tgtagggaaa ttttgaagta gtttttgcta aaaaattatt     3480

tctagagttg tgttattctt agcagtaatc ttggctagaa atgtttttgt gatttatgcg     3540

attaaacgaa atgataaaga taaaaccata ttattaaata cctatatatc acagctaagt     3600

aggagaaagg gagacctttt tattttgttc aggtaggagt atttcttgtg tattttagaa     3660

acaattattt ttcccattat ttcttatgag attagttgtt tcaagtagga gacagaaaag     3720

ttctgttttg ttggaaatgt aggttttaga tgtatctttc agtcagctct cagtcactag     3780

actatttcat attttttgaa atgtttttga aaattatgac tagcccattt tttgtccttt     3840

attcaacata cttatcctct gaacacataa ataagtgaat aagataaaaa tatctttacc     3900

ttattaatat tatacatact tgaaaaaaat ttcatttaga aacctagttc agaatctgag     3960

caaatttaca agtgacctct gtaataaatg gtattgataa tcagagaatg tatttcagaa     4020

tactacagta caatatatta tgaagcatga ccactttatt ttgaaactta gcaattgtat     4080

tgctggggtt tattgtatct gtagcatgtc actgattatt tcagttagtt ttataatgat     4140

ttttaaaaaa catatctatt tggaataaga tacagcaaca atcattgcta ctgacttgtt     4200

caacccctta gttacactgt atgatcaaca tataacaaga tacagtggaa tggcccatac     4260

agtatattac tgttgtgtga tgattggctt tggaagcagt ttgattttga aatgctttga     4320

tattctaatt gacatggaac aagttttttc cctgctcccc aaatagaatt ttgtaaccaa     4380

ctttgctatt tttttaaagt ttgtaagaat gtgtcatttc ttggggagta gccatccatc     4440

aacaaatatc ctgactgcta ctttgttata tacaaaatac ttacattgaa cctggtggca     4500

taatgagtat tttgaaagaa gaaatttctt cactctcatt tttatagaaa tcttggaatc     4560

agcttaagct gtagctttta tgacaaaaga cagtcatttt tggtcagagt gatatttggt     4620

gacggaaact tgttcataat ttattgttac tatagaacta tttggatttt ctcattttta     4680

gttctgatag ttaaatattt tggtttgttc tgtgccttca gtttaaatta tttcaggatt     4740

tttcagatgt ttaaataatg gtgtgaatca ttcaggatgg aaataaaagt catcctttct     4800

gtaa                                                                  4804


<210>  193
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Gly Thr Thr Ser Asp Glu Met Val Ser Val Glu Gln Thr Ser Ser 
1               5                   10                  15      


Ser Ser Leu Asn Pro Leu Cys Phe Glu Cys Gly Gln Gln His Trp Thr 
            20                  25                  30          


Arg Glu Asn His Leu Tyr Asn Tyr Gln Asn Glu Val Asp Asp Asp Leu 
        35                  40                  45              


Val Cys His Ile Cys Leu Gln Pro Leu Leu Gln Pro Leu Asp Thr Pro 
    50                  55                  60                  


Cys Gly His Thr Phe Cys Tyr Lys Cys Leu Arg Asn Phe Leu Gln Glu 
65                  70                  75                  80  


Lys Asp Phe Cys Pro Leu Asp Arg Lys Arg Leu His Phe Lys Leu Cys 
                85                  90                  95      


Lys Lys Ser Ser Ile Leu Val His Lys Leu Leu Asp Lys Leu Leu Val 
            100                 105                 110         


Leu Cys Pro Phe Ser Ser Val Cys Lys Asp Val Met Gln Arg Cys Asp 
        115                 120                 125             


Leu Glu Ala His Leu Lys Asn Arg Cys Pro Gly Ala Ser His Arg Arg 
    130                 135                 140                 


Val Ala Leu Glu Arg Arg Lys Thr Ser Arg Thr Gln Ala Glu Ile Glu 
145                 150                 155                 160 


Asn Glu Asn Gly Pro Thr Leu Leu Asp Pro Ala Gly Thr Leu Ser Pro 
                165                 170                 175     


Glu Ala Asp Cys Leu Gly Thr Gly Ala Val Pro Val Glu Arg His Leu 
            180                 185                 190         


Thr Ser Ala Ser Leu Ser Thr Trp Ser Glu Glu Pro Gly Leu Asp Asn 
        195                 200                 205             


Pro Ala Phe Glu Glu Ser Ala Gly Ala Asp Thr Thr Gln Gln Pro Leu 
    210                 215                 220                 


Ser Leu Pro Glu Gly Glu Ile Thr Thr Ile Glu Ile His Arg Ser Asn 
225                 230                 235                 240 


Pro Tyr Ile Gln Leu Gly Ile Ser Ile Val Gly Gly Asn Glu Thr Pro 
                245                 250                 255     


Leu Ile Asn Ile Val Ile Gln Glu Val Tyr Arg Asp Gly Val Ile Ala 
            260                 265                 270         


Arg Asp Gly Arg Leu Leu Ala Gly Asp Gln Ile Leu Gln Val Asn Asn 
        275                 280                 285             


Tyr Asn Ile Ser Asn Val Ser His Asn Tyr Ala Arg Ala Val Leu Ser 
    290                 295                 300                 


Gln Pro Cys Asn Thr Leu His Leu Thr Val Leu Arg Glu Arg Arg Phe 
305                 310                 315                 320 


Gly Asn Arg Ala His Asn His Ser Asp Ser Asn Ser Pro Arg Glu Glu 
                325                 330                 335     


Ile Phe Gln Val Ala Leu His Lys Arg Asp Ser Gly Glu Gln Leu Gly 
            340                 345                 350         


Ile Lys Leu Val Arg Arg Thr Asp Glu Pro Gly Val Phe Ile Leu Asp 
        355                 360                 365             


Leu Leu Glu Gly Gly Leu Ala Ala Gln Asp Gly Arg Leu Ser Ser Asn 
    370                 375                 380                 


Asp Arg Val Leu Ala Ile Asn Gly His Asp Leu Lys Tyr Gly Thr Pro 
385                 390                 395                 400 


Glu Leu Ala Ala Gln Ile Ile Gln Ala Ser Gly Glu Arg Val Asn Leu 
                405                 410                 415     


Thr Ile Ala Arg Pro Gly Lys Pro Gln Pro Gly Asn Thr Ile Arg Glu 
            420                 425                 430         


Ala Gly Asn His Ser Ser Ser Ser Gln His His Thr Pro Pro Pro Tyr 
        435                 440                 445             


Tyr Ser Arg Pro Ser Ser His Lys Asp Leu Thr Gln Cys Val Thr Cys 
    450                 455                 460                 


Gln Glu Lys His Ile Thr Val Lys Lys Glu Pro His Glu Ser Leu Gly 
465                 470                 475                 480 


Met Thr Val Ala Gly Gly Arg Gly Ser Lys Ser Gly Glu Leu Pro Ile 
                485                 490                 495     


Phe Val Thr Ser Val Pro Pro His Gly Cys Leu Ala Arg Asp Gly Arg 
            500                 505                 510         


Ile Lys Arg Gly Asp Val Leu Leu Asn Ile Asn Gly Ile Asp Leu Thr 
        515                 520                 525             


Asn Leu Ser His Ser Glu Ala Val Ala Met Leu Lys Ala Ser Ala Ala 
    530                 535                 540                 


Ser Pro Ala Val Ala Leu Lys Ala Leu Glu Val Gln Ile Val Glu Glu 
545                 550                 555                 560 


Ala Thr Gln Asn Ala Glu Glu Gln Pro Ser Thr Phe Ser Glu Asn Glu 
                565                 570                 575     


Tyr Asp Ala Ser Trp Ser Pro Ser Trp Val Met Trp Leu Gly Leu Pro 
            580                 585                 590         


Ser Thr Leu His Ser Cys His Asp Ile Val Leu Arg Arg Ser Tyr Leu 
        595                 600                 605             


Gly Ser Trp Gly Phe Ser Ile Val Gly Gly Tyr Glu Glu Asn His Thr 
    610                 615                 620                 


Asn Gln Pro Phe Phe Ile Lys Thr Ile Val Leu Gly Thr Pro Ala Tyr 
625                 630                 635                 640 


Tyr Asp Gly Arg Leu Lys Cys Gly Asp Met Ile Val Ala Val Asn Gly 
                645                 650                 655     


Leu Ser Thr Val Gly Met Ser His Ser Ala Leu Val Pro Met Leu Lys 
            660                 665                 670         


Glu Gln Arg Asn Lys Val Thr Leu Thr Val Ile Cys Trp Pro Gly Ser 
        675                 680                 685             


Leu Val 
    690 


<210>  194
<211>  8708
<212>  DNA
<213>  Homo sapiens

<400>  194
gtaaaggact ggggccccgc aactggcctc tcctgccctc ttaagcgcag cgccatttta       60

gcaacgcaga agcccggcgc cgggaagcct cagctcgcct gaaggcaggt cccctctgac      120

gcctccggga gcccaggttt cccagagtcc ttgggacgca gcgacgagtt gtgctgctat      180

cttagctgtc cttataggct ggccattcca ggtggtggta tttagataaa accactcaaa      240

ctctgcagtt tggtcttggg gtttggagga aagcttttat ttttcttcct gctccggttc      300

agaaggtctg aagctcatac ctaaccaggc ataacacaga atctgcaaaa caaaaacccc      360

taaaaaagca gacccagagc agtgtaaaca cttctgggtg tgtccctgac tggctgccca      420

aggtctctgt gtcttcggag acaaagccat tcgcttagtt ggtctacttt aaaaggccac      480

ttgaactcgc tttccatggc gatttgcctt gtgagcactt tcaggagagc ctggaagctg      540

aaaaacggta gaaaaatttc cgtgcgggcc gtggggggct ggcggcaact ggggggccgc      600

agatcagagt gggccactgg cagccaacgg cccccggggc tcaggcgggg agcagctctg      660

tggtgtggga ttgaggcgtt ttccaagagt gggttttcac gtttctaaga tttcccaagc      720

agacagcccg tgctgctccg atttctcgaa caaaaaagca aaacgtgtgg ctgtcttggg      780

agcaagtcgc aggactgcaa gcagttgggg gagaaagtcc gccattttgc cacttctcaa      840

ccgtccctgc aaggctgggg ctcagttgcg taatggaaag taaagccctg aactatcaca      900

ctttaatctt ccttcaaaag gtggtaaact atacctactg tccctcaaga gaacacaaga      960

agtgctttaa gaggtatttt aaaagttccg ggggttttgt gaggtgtttg atgacccgtt     1020

taaaatatga tttccatgtt tcttttgtct aaagtttgca gctcaaatct ttccacacgc     1080

tagtaattta agtatttctg catgtgtagt ttgcattcaa gttccataag ctgttaagaa     1140

aaatctagaa aagtaaaact agaacctatt tttaaccgaa gaactacttt ttgcctccct     1200

cacaaaggcg gcggaaggtg atcgaattcc ggtgatgcga gttgttctcc gtctataaat     1260

acgcctcgcc cgagctgtgc ggtaggcatt gaggcagcca gcgcaggggc ttctgctgag     1320

ggggcaggcg gagcttgagg aaaccgcaga taagtttttt tctctttgaa agatagagat     1380

taatacaact acttaaaaaa tatagtcaat aggttactaa gatattgctt agcgttaagt     1440

ttttaacgta attttaatag cttaagattt taagagaaaa tatgaagact tagaagagta     1500

gcatgaggaa ggaaaagata aaaggtttct aaaacatgac ggaggttgag atgaagcttc     1560

ttcatggagt aaaaaatgta tttaaaagaa aattgagaga aaggactaca gagccccgaa     1620

ttaataccaa tagaagggca atgcttttag attaaaatga aggtgactta aacagcttaa     1680

agtttagttt aaaagttgta ggtgattaaa ataatttgaa ggcgatcttt taaaaagaga     1740

ttaaaccgaa ggtgattaaa agaccttgaa atccatgacg cagggagaat tgcgtcattt     1800

aaagcctagt taacgcattt actaaacgca gacgaaaatg gaaagattaa ttgggagtgg     1860

taggatgaaa caatttggag aagatagaag tttgaagtgg aaaactggaa gacagaagta     1920

cgggaaggcg aagaaaagaa tagagaagat agggaaatta gaagataaaa acatactttt     1980

agaagaaaaa agataaattt aaacctgaaa agtaggaagc agaagaaaaa agacaagcta     2040

ggaaacaaaa agctaagggc aaaatgtaca aacttagaag aaaattggaa gatagaaaca     2100

agatagaaaa tgaaaatatt gtcaagagtt tcagatagaa aatgaaaaac aagctaagac     2160

aagtattgga gaagtataga agatagaaaa atataaagcc aaaaattgga taaaatagca     2220

ctgaaaaaat gaggaaatta ttggtaacca atttatttta aaagcccatc aatttaattt     2280

ctggtggtgc agaagttaga aggtaaagct tgagaagatg agggtgttta cgtagaccag     2340

aaccaattta gaagaatact tgaagctaga aggggaagtt ggttaaaaat cacatcaaaa     2400

agctactaaa aggactggtg taatttaaaa aaaactaagg cagaaggctt ttggaagagt     2460

tagaagaatt tggaaggcct taaatatagt agcttagttt gaaaaatgtg aaggactttc     2520

gtaacggaag taattcaaga tcaagagtaa ttaccaactt aatgtttttg cattggactt     2580

tgagttaaga ttatttttta aatcctgagg actagcatta attgacagct gacccaggtg     2640

ctacacagaa gtggattcag tgaatctagg aagacagcag cagacaggat tccaggaacc     2700

agtgtttgat gaagctagga ctgaggagca agcgagcaag cagcagttcg tggtgaagat     2760

aggaaaagag tccaggagcc agtgcgattt ggtgaaggaa gctaggaaga aggaaggagc     2820

gctaacgatt tggtggtgaa gctaggaaaa aggattccag gaaggagcga gtgcaatttg     2880

gtgatgaagg tagcaggcgg cttggcttgg caaccacacg gaggaggcga gcaggcgttg     2940

tgcgtagagg atcctagacc agcatgccag tgtgccaagg ccacagggaa agcgagtggt     3000

tggtaaaaat ccgtgaggtc ggcaatatgt tgtttttctg gaacttactt atggtaacct     3060

tttatttatt ttctaatata atgggggagt ttcgtactga ggtgtaaagg gatttatatg     3120

gggacgtagg ccgatttccg ggtgttgtag gtttctcttt ttcaggctta tactcatgaa     3180

tcttgtctga agcttttgag ggcagactgc caagtcctgg agaaatagta gatggcaagt     3240

ttgtgggttt ttttttttta cacgaatttg aggaaaacca aatgaatttg atagccaaat     3300

tgagacaatt tcagcaaatc tgtaagcagt ttgtatgttt agttggggta atgaagtatt     3360

tcagttttgt gaatagatga cctgttttta cttcctcacc ctgaattcgt tttgtaaatg     3420

tagagtttgg atgtgtaact gaggcggggg ggagttttca gtattttttt ttgtgggggt     3480

gggggcaaaa tatgttttca gttctttttc ccttaggtct gtctagaatc ctaaaggcaa     3540

atgactcaag gtgtaacaga aaacaagaaa atccaatatc aggataatca gaccaccaca     3600

ggtttacagt ttatagaaac tagagcagtt ctcacgttga ggtctgtgga agagatgtcc     3660

attggagaaa tggctggtag ttactctttt ttccccccac ccccttaatc agactttaaa     3720

agtgcttaac cccttaaact tgttattttt tacttgaagc attttgggat ggtcttaaca     3780

gggaagagag agggtggggg agaaaatgtt tttttctaag attttccaca gatgctatag     3840

tactattgac aaactgggtt agagaaggag tgtaccgctg tgctgttggc acgaacacct     3900

tcagggactg gagctgcttt tatccttgga agagtattcc cagttgaagc tgaaaagtac     3960

agcacagtgc agctttggtt catattcagt catctcagga gaacttcaga agagcttgag     4020

taggccaaat gttgaagtta agttttccaa taatgtgact tcttaaaagt tttattaaag     4080

gggaggggca aatattggca attagttggc agtggcctgt tacggttggg attggtgggg     4140

tgggtttagg taattgttta gtttatgatt gcagataaac tcatgccaga gaacttaaag     4200

tcttagaatg gaaaaagtaa agaaatatca acttccaagt tggcaagtaa ctcccaatga     4260

tttagttttt ttccccccag tttgaattgg gaagctgggg gaagttaaat atgagccact     4320

gggtgtacca gtgcattaat ttgggcaagg aaagtgtcat aatttgatac tgtatctgtt     4380

ttccttcaaa gtatagagct tttggggaag gaaagtattg aactgggggt tggtctggcc     4440

tactgggctg acattaacta caattatggg aaatgcaaaa gttgtttgga tatggtagtg     4500

tgtggttctc ttttggaatt tttttcaggt gatttaataa taatttaaaa ctactataga     4560

aactgcagag caaaggaagt ggcttaatga tcctgaaggg atttcttctg atggtagctt     4620

ttgtattatc aagtaagatt ctattttcag ttgtgtgtaa gcaagttttt ttttagtgta     4680

ggagaaatac ttttccattg tttaactgca aaacaagatg ttaaggtatg cttcaaaaat     4740

tttgtaaatt gtttatttta aacttatctg tttgtaaatt gtaactgatt aagaattgtg     4800

atagttcagc ttgaatgtct cttagagggt gggcttttgt tgatgaggga ggggaaactt     4860

tttttttttc tatagacttt tttcagataa catcttctga gtcataacca gcctggcagt     4920

atgatggcct agatgcagag aaaacagctc cttggtgaat tgataagtaa aggcagaaaa     4980

gattatatgt catacctcca ttggggaata agcataaccc tgagattctt actactgatg     5040

agaacattat ctgcatatgc caaaaaattt taagcaaatg aaagctacca atttaaagtt     5100

acggaatcta ccattttaaa gttaattgct tgtcaagcta taaccacaaa aataatgaat     5160

tgatgagaaa tacaatgaag aggcaatgtc catctcaaaa tactgctttt acaaaagcag     5220

aataaaagcg aaaagaaatg aaaatgttac actacattaa tcctggaata aaagaagccg     5280

aaataaatga gagatgagtt gggatcaagt ggattgagga ggctgtgctg tgtgccaatg     5340

tttcgtttgc ctcagacagg tatctcttcg ttatcagaag agttgcttca tttcatctgg     5400

gagcagaaaa cagcaggcag ctgttaacag ataagtttaa cttgcatctg cagtattgca     5460

tgttagggat aagtgcttat ttttaagagc tgtggagttc ttaaatatca accatggcac     5520

tttctcctga ccccttccct aggggatttc aggattgaga aatttttcca tcgagccttt     5580

ttaaaattgt aggacttgtt cctgtgggct tcagtgatgg gatagtacac ttcactcaga     5640

ggcatttgca tctttaaata atttcttaaa agcctctaaa gtgatcagtg ccttgatgcc     5700

aactaaggaa atttgtttag cattgaatct ctgaaggctc tatgaaagga atagcatgat     5760

gtgctgttag aatcagatgt tactgctaaa atttacatgt tgtgatgtaa attgtgtaga     5820

aaaccattaa atcattcaaa ataataaact atttttatta gagaatgtat acttttagaa     5880

agctgtctcc ttatttaaat aaaatagtgt ttgtctgtag ttcagtgttg gggcaatctt     5940

gggggggatt cttctctaat ctttcagaaa ctttgtctgc gaacactctt taatggacca     6000

gatcaggatt tgagcggaag aacgaatgta actttaaggc aggaaagaca aattttattc     6060

ttcataaagt gatgagcata taataattcc aggcacatgg caatagaggc cctctaaata     6120

aggaataaat aacctcttag acaggtggga gattatgatc agagtaaaag gtaattacac     6180

attttatttc cagaaagtca ggggtctata aattgacagt gattagagta atactttttc     6240

acatttccaa agtttgcatg ttaactttaa atgcttacaa tcttagagtg gtaggcaatg     6300

ttttacacta ttgaccttat atagggaagg gagggggtgc ctgtggggtt ttaaagaatt     6360

ttcctttgca gaggcatttc atccttcatg aagccattca ggattttgaa ttgcatatga     6420

gtgcttggct cttccttctg ttctagtgag tgtatgagac cttgcagtga gtttatcagc     6480

atactcaaaa tttttttcct ggaatttgga gggatgggag gagggggtgg ggcttacttg     6540

ttgtagcttt tttttttttt acagacttca cagagaatgc agttgtcttg acttcaggtc     6600

tgtctgttct gttggcaagt aaatgcagta ctgttctgat cccgctgcta ttagaatgca     6660

ttgtgaaacg actggagtat gattaaaagt tgtgttcccc aatgcttgga gtagtgattg     6720

ttgaaggaaa aaatccagct gagtgataaa ggctgagtgt tgaggaaatt tctgcagttt     6780

taagcagtcg tatttgtgat tgaagctgag tacattttgc tggtgtattt ttaggtaaaa     6840

tgctttttgt tcatttctgg tggtgggagg ggactgaagc ctttagtctt ttccagatgc     6900

aaccttaaaa tcagtgacaa gaaacattcc aaacaagcaa cagtcttcaa gaaattaaac     6960

tggcaagtgg aaatgtttaa acagttcagt gatctttagt gcattgttta tgtgtgggtt     7020

tctctctccc ctcccttggt cttaattctt acatgcagga acactcagca gacacacgta     7080

tgcgaagggc cagagaagcc agacccagta agaaaaaata gcctatttac tttaaataaa     7140

ccaaacattc cattttaaat gtggggattg ggaaccacta gttctttcag atggtattct     7200

tcagactata gaaggagctt ccagttgaat tcaccagtgg acaaaatgag gaaaacaggt     7260

gaacaagctt tttctgtatt tacatacaaa gtcagatcag ttatgggaca atagtattga     7320

atagatttca gctttatgct ggagtaactg gcatgtgagc aaactgtgtt ggcgtggggg     7380

tggaggggtg aggtgggcgc taagcctttt tttaagattt ttcaggtacc cctcactaaa     7440

ggcaccgaag gcttaaagta ggacaaccat ggagccttcc tgtggcagga gagacaacaa     7500

agcgctatta tcctaaggtc aagagaagtg tcagcctcac ctgattttta ttagtaatga     7560

ggacttgcct caactccctc tttctggagt gaagcatccg aaggaatgct tgaagtaccc     7620

ctgggcttct cttaacattt aagcaagctg tttttatagc agctcttaat aataaagccc     7680

aaatctcaag cggtgcttga aggggaggga aagggggaaa gcgggcaacc acttttccct     7740

agcttttcca gaagcctgtt aaaagcaagg tctccccaca agcaacttct ctgccacatc     7800

gccaccccgt gccttttgat ctagcacaga cccttcaccc ctcacctcga tgcagccagt     7860

agcttggatc cttgtgggca tgatccataa tcggtttcaa ggtaacgatg gtgtcgaggt     7920

ctttggtggg ttgaactatg ttagaaaagg ccattaattt gcctgcaaat tgttaacaga     7980

agggtattaa aaccacagct aagtagctct attataatac ttatccagtg actaaaacca     8040

acttaaacca gtaagtggag aaataacatg ttcaagaact gtaatgctgg gtgggaacat     8100

gtaacttgta gactggagaa gataggcatt tgagtggctg agagggcttt tgggtgggaa     8160

tgcaaaaatt ctctgctaag actttttcag gtgaacataa cagacttggc caagctagca     8220

tcttagcgga agctgatctc caatgctctt cagtagggtc atgaaggttt ttcttttcct     8280

gagaaaacaa cacgtattgt tttctcaggt tttgcttttt ggcctttttc tagcttaaaa     8340

aaaaaaaaag caaaagatgc tggtggttgg cactcctggt ttccaggacg gggttcaaat     8400

ccctgcggcg tctttgcttt gactactaat ctgtcttcag gactctttct gtatttctcc     8460

ttttctctgc aggtgctagt tcttggagtt ttggggaggt gggaggtaac agcacaatat     8520

ctttgaacta tatacatcct tgatgtataa tttgtcagga gcttgacttg attgtatatt     8580

catatttaca cgagaaccta atataactgc cttgtctttt tcaggtaata gcctgcagct     8640

ggtgttttga gaagccctac tgctgaaaac ttaacaattt tgtgtaataa aaatggagaa     8700

gctctaaa                                                              8708


<210>  195
<211>  6469
<212>  DNA
<213>  Homo sapiens

<400>  195
ggcgcttcct gttccggcgc caggaggagc cgcgcgctgc tggtgctgtt gccgccgctg       60

ctctagctgc cgtcagtcag gctgcgcccg cgtcttcagg gcccagtccc tcggacccat      120

cgccgcttct agaccctact gcggtctcgg atattgccgg gaaaatgtct gatgaatttt      180

cgttggcaga tgcactacct gaacactccc ctgccaaaac ctctgctgtg agcaatacaa      240

aacctggcca acctcctcaa ggctggccag gctccaaccc ttggaataat ccgagtgctc      300

catcttcagt gccatctgga ctcccaccaa gtgcaacacc ctccactgtg ccttttggac      360

cagcaccaac aggaatgtat ccctccgtgc ctcccaccgg accacctcca ggacccccag      420

caccctttcc tccttccgga ccatcatgtc ccccacctgg tggtccttat ccagccccaa      480

ctgtgccggg ccctggcccc acagggccat atcctacacc aaatatgccc tttccagagc      540

tacccagacc atatggtgca cccacagatc cagctgcagc tggtccttta ggtccatggg      600

gatccatgtc ttctggacct tgggcgccag gaatgggagg gcagtatcct acccctaata      660

tgccatatcc atctccaggc ccatatcccg ctcctcctcc tccccaagcc cctggggcag      720

caccacctgt tccatggggc accgttccac caggagcctg gggaccacca gcaccatatc      780

ctgcccctac aggatcgtat cccacaccag gactctatcc tactcccagt aatcctttcc      840

aagtgccttc aggaccttct ggtgctccac caatgcctgg tggcccccat tcttaccatt      900

aagttaacaa tggacgaaga gatgacgctt tgctttttga agtacatgta tatgcacatg      960

aatgcatata taaaaattgc tggtttcact attagagggc attcatgaaa gaacaactct     1020

tgcacctctc agagaagata actgcctctt gtacttggat gcgtagtaca tcatatgtat     1080

acaatcagat aaaagcatag aagtaaatca ttcggatgtg atttttattt ggttttcatg     1140

gaaagttaaa gtgataaagt atattgaata gttctttgac agaatttgtt taaactatga     1200

aactacacac ttaaaaatct aagatgtgga ttattgttag aatctgcaac ttcattggca     1260

aattatttca agtatttttc tataatcact ttccccttct aaataaataa acttcgagaa     1320

taacccatca taatccaaac aaatgatgcc tcaacatttt gagctgctct gtcggacaaa     1380

taaacctggt cctcttgagg ttatattttg gatatacatt tttaaactgt cagtaattat     1440

tgtcagatgt ggagttcaat agccagccag tgttcatttt tatccttgag cttttagtaa     1500

aaacttcctg gttttatttt tagtcattgg gtcatacagc actaaagtct gctatttatg     1560

gaaactaact tttttgtttt taatccaggc caacatgtat gtaaattaaa tttttagata     1620

attgattatc tctttgtact acttgagatt tgattatgag atgtgcatat tgctttggga     1680

agagctcgag gaaggaaata attctctcct ttgttttgaa cctcaaacta gataaaccct     1740

aggaattgct taactgcaac aagtaatttt cattcccaca aaaacctgag gcagctcttt     1800

tgcccagagc gttccctgta gccaccccca ccccacttgc ccttggttct ttagaaggag     1860

cacacacatc ccttgattcc tccctgatgt ggtaaactgg cacactccag gggtctaaaa     1920

cataaaacag ttgtgtttag ggaaccttaa gtcatgcaga catgactgtt ctctttgtac     1980

aagtgtgaat caaaatatgt atctcttttt cagagtctgg ttaagctatg tcattgtcta     2040

ctgcatagtt tcctgagtct gtttgtaaag tgcttatggc taacagttca gttctgtatt     2100

tgttgacagg taaataagtg gagttgagtg ccatctttga aaaaattacc ctctagctct     2160

aacactgaaa ataataataa attgtagatc tctgcaacta agtttaaagc agtgtgactg     2220

tgttgcttaa atatcaagta ttgtttataa ccaccaaaaa aaaaaagccc tggtagtttt     2280

ttggcacctt atgtttaaat cagattctta gatttggagt agacctgacc ttgttattta     2340

ttagataaca ttttgaatgt atccattgga tttctaaaat gtattgtgaa tttctcagac     2400

aaacaggatt tatgctggag ctctgttttg cttagaaata aaatatttag tagtttattt     2460

ctgctctaat taaaatgtca agaatgccaa atgctgccag ttttttggtt tgatagctac     2520

ctccttctaa gaaagcaaaa tggttacctt tgagaggaac attcagtgtt taatcatccc     2580

ttatgttaac tagatgatag attcaagctt ttagaaatga gaaagtagaa actaatttgt     2640

taagatattt tcagactgcg gaatgttgtt agctttttct ttcacttctc ttcaaggaca     2700

ggtgttagct gtctacaata ctgttgaact ctgttgtcaa agtagccccc ttagtctaca     2760

aggcaggtag ccttggcttg aattatcaat atcaaaatgt cagttaacca tggagggata     2820

aagtaatgtg aaaagtgaga tggctgcaaa gatagctctc cttacagtta ttttggctgt     2880

cctacattgg gataagctga caaattagca gtatttagtt taacactgga gcaaatataa     2940

tttgagtagg aagaagagat agcaggtttg ggaatctata attatgaagt ccattgattt     3000

tgggagaaaa tctgttgcta aaggatttga agggccatga acacaatttg ggattattac     3060

tccctataag tataataatt ttgctagtga cccatactgt ccagtgtgcc ctaaatcata     3120

ctgctattgt actccctttg ttttcaagga ctttgcaact ggtatttggg ggagattttt     3180

tttttttttt gagacggagt ctcgctctgt cgcccatgct ggagtgcagt ggtgctatct     3240

tggttcactg caagctccat ctcccaggtt cacaccattc tcctgcctca gcctcccaag     3300

cagctgggac tacaggtgcc cgccaccatg cccggctaat tttttttttt tttttttttt     3360

agtagagatg gggtttcact gtgttagcca ggatggtctc gatctcctga cctcgtgatc     3420

tgcccgcctt ggcttcccaa agtgctggga ttacaggcgt gagccaccac gtccggccga     3480

tttttttttt tttttttaat gtaagaatgg agataaaagg gataatataa tttgctttta     3540

tattgttatt tttgtaaagc atcttttctt caattcttgt tggcattctg ggccaaaata     3600

tttcaggttg gttcggtgtg gagttaagaa aagcaggcgt tttagtggag aaatggggaa     3660

cagcatcaag aaaggctttt ttcctttttt cttttttttt tggagacaga gtcttgccct     3720

gtcacccagg ctggagtgca atggcgtgat cttggctcgc tgcaacctct gcctccaggt     3780

tcaaacgatt cttctgcctc agcctcccaa gtagctggga ttacaggtgc ccgccaccac     3840

acccattttt gtatttttag tagagacggg ggtttcacca tgttggccag ggtggtctga     3900

aactcctgac ctcgtgatcc gcctgcctca gcctcccaaa gtgctgagat tacaggcgtg     3960

agccaccatg cgtgaccttt ttttcttttt aaaagggaac aatgttgctt tcaaaacaag     4020

acatgctagg ctgaaactga tttatggaaa agactgcttg ttagcaagta tatttggtct     4080

tgagggggat acagattata gaatatgctg acatttgggc ttcagaggaa gaattttcaa     4140

atctaatgga aatagttgag gtgttcagga atgctgtttc ttggagttgg aagcttaggt     4200

tttgaaatgt tgaaaccaaa aagacaaaaa ttaaaacata gaccttaggt cgtcattcac     4260

acccggttct caagaatcaa gtggagcact tcaaagacct tggcttgtct gtcccatcct     4320

gccactttct catcttttca tgcttttgaa gacaccattt acagctctga ctcagcccta     4380

ttttgtgtaa agtaatatat tgattattca gaaatagaca atacattttt taattaccca     4440

aggactgact gttttgtgca ttttactgtt ggttgtcttc agtagagaat agtaataggg     4500

cagagaaaag tatatatttt gcctcagtca gtcccaccac cacaatggac tattgggata     4560

ttttctaaaa aaccaatcaa tttgcccatg attacctcac aaataattag tgctacctgg     4620

ggtactctca aatatacagc ttttgaaact gtagatgaaa aaagctctac tcagagtttt     4680

tgtcaagact gtgcctgggt tgaatatcag tcaattgcct acacttctaa acaataagtg     4740

ccaatgtctc aattttctca ccctgaatga tagaagctag ctttatcaaa tgccaaggtt     4800

agaaagcctg gaaataaaac ttaagcacag acattcaagt ttttgaaaag cataagccta     4860

aattcagata aatcacactg atatattgta ctatgcatag aaagttgtag gtggcgttca     4920

gggaagactt tgattttaat aaagcaatat ttagtattga agacaaacac tttttatttt     4980

cagatttctg ccaagtaaaa cagaaattgc caataaaata atcagtattt tgtaaatggc     5040

aggcaagctt ctggctgtcg aaaacatctg agtcatttat tcagtagaca atatgtcctt     5100

gatccaggtt ctttgccagc tataagggaa tccctgtcct tgagaggctc atagtctata     5160

agtaacatta cagaatttgt tagcataccc attcattatt agttttacct aaacgtgtta     5220

ggatcactac tggtggaaat tgtaaccagc ctttgggcat cttaaagggt gacatgtggc     5280

atgccttttt ttttttttaa gaatttaatg tttttcaaga ttgtagtgtt gatcagcgca     5340

acaattcaag tgtgcaaagt aacaggatag tttgcctctt cactttaccc ctggataaag     5400

gcactttcac tgcctgtcac tgatcagcag atactgactt gttgccatta agtgaacttg     5460

acttcttatg tgtgctctat gagtttgttg taattttctt cttgaaattg tgatttttca     5520

ctgacagtaa tgacaaattt aatgtatgta attgtctatg cattttaagt taaactgcct     5580

aaaatgtgat ttgagacata tacatatgtt tgtattataa attgtaagca atcagtttga     5640

gatactaggt tttatcacct gctgctgtat ttgtaaacaa agacaaatgt tgctttaaga     5700

agtaattata attaggaata ggctatggat gtgatacttg gtatttttta agataaactt     5760

gtttgctttt gtgtattata cctggaaact ttttttaaaa aatgtatttt catggtttca     5820

cagatttttc atgttatttt attctttagg cccaattctg ggcttctctg agcaagtcca     5880

gagcctaatt aactgtaaat ttgttgtcaa aaaggaagaa aaaagggcct gagatacctc     5940

tttgcatgtg acctgcattc actaaggata tctggaaacc acccttcctc cgcaaaccct     6000

ctcagcaaca tggtgtccat tgtggtgatt ttctcttctt ttaaggctag gctactcttg     6060

gtaaccagat tatccgtata tatgataata tgaagtcagg gaactttctc tgtctgtccc     6120

tactcccctc actcccccac tttctgttat gaaagatagt tctactttta tcattaactg     6180

ctacgcattt agtgagggtc acattattaa acttggagtt taccattttc ccacaggaga     6240

tttcgctggc attccttgga actcccaatt tcagtagggc aatgaatgaa tgaatacttt     6300

gcagtgctac ttttggaagg aatttctgct ttttgcctta tgattggaca aaatgcagct     6360

gtaaaatttt aaattgtttt tgatatgtta ttcaatatcc catgaaagta ttcacctaaa     6420

gtggagttat gaaatggatg gtgaaataat aagaccattc tggagcagg                 6469


<210>  196
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Ser Asp Glu Phe Ser Leu Ala Asp Ala Leu Pro Glu His Ser Pro 
1               5                   10                  15      


Ala Lys Thr Ser Ala Val Ser Asn Thr Lys Pro Gly Gln Pro Pro Gln 
            20                  25                  30          


Gly Trp Pro Gly Ser Asn Pro Trp Asn Asn Pro Ser Ala Pro Ser Ser 
        35                  40                  45              


Val Pro Ser Gly Leu Pro Pro Ser Ala Thr Pro Ser Thr Val Pro Phe 
    50                  55                  60                  


Gly Pro Ala Pro Thr Gly Met Tyr Pro Ser Val Pro Pro Thr Gly Pro 
65                  70                  75                  80  


Pro Pro Gly Pro Pro Ala Pro Phe Pro Pro Ser Gly Pro Ser Cys Pro 
                85                  90                  95      


Pro Pro Gly Gly Pro Tyr Pro Ala Pro Thr Val Pro Gly Pro Gly Pro 
            100                 105                 110         


Thr Gly Pro Tyr Pro Thr Pro Asn Met Pro Phe Pro Glu Leu Pro Arg 
        115                 120                 125             


Pro Tyr Gly Ala Pro Thr Asp Pro Ala Ala Ala Gly Pro Leu Gly Pro 
    130                 135                 140                 


Trp Gly Ser Met Ser Ser Gly Pro Trp Ala Pro Gly Met Gly Gly Gln 
145                 150                 155                 160 


Tyr Pro Thr Pro Asn Met Pro Tyr Pro Ser Pro Gly Pro Tyr Pro Ala 
                165                 170                 175     


Pro Pro Pro Pro Gln Ala Pro Gly Ala Ala Pro Pro Val Pro Trp Gly 
            180                 185                 190         


Thr Val Pro Pro Gly Ala Trp Gly Pro Pro Ala Pro Tyr Pro Ala Pro 
        195                 200                 205             


Thr Gly Ser Tyr Pro Thr Pro Gly Leu Tyr Pro Thr Pro Ser Asn Pro 
    210                 215                 220                 


Phe Gln Val Pro Ser Gly Pro Ser Gly Ala Pro Pro Met Pro Gly Gly 
225                 230                 235                 240 


Pro His Ser Tyr His 
                245 


<210>  197
<211>  6046
<212>  DNA
<213>  Homo sapiens

<400>  197
aggccccacc cgctggtggc ccggtccgcg tgtgcgccga ctctcgcact ctcctcgctc       60

cgggcgccca gactctgaga gagagcgacg gccatcatag aacagcgaag gcagtcgatc      120

ggcctgcggt ccgcttcggc attcgcaggc cgcaggcggg aggctagagc ccccaggcgc      180

acctcgcccc aaccgcccgc ggctcgggca gctctgcaga gacgtcgtgg cggcagggcc      240

agcacccatt ggtccgccac agccctccgc cctccccctc gccacgctta ttggccggag      300

cggcggcgct cgccgggtag gcggtggcgg cgtccctccc ttgcgccggc cctcaagagg      360

cgacgaggaa gcggccgcct ccctgcgccc cgcccctccg gctagctcgc tggctcccgg      420

ctcctcccga cgtctcctac ctcctcacgg ctcttcccgg cgctctcctg gctcccttct      480

gccccagctc cgtctcggcg gcggcgggca gttgcagtgg tgcagaatgg ctgacctcag      540

tcttgcagat gcattaacag aaccatctcc agacattgag ggagagataa agcgggactt      600

cattgccaca ctagaggcag aggcctttga tgatgttgtg ggagaaactg ttggaaaaac      660

agactatatt cctctcctgg atgttgatga gaaaaccggg aactcagagt caaagaagaa      720

accgtgctca gaaactagcc agattgaaga tactccatct tctaaaccaa cactcctagc      780

caatggtggt catggagtag aagggagcga tactacaggg tctccaactg aattccttga      840

agagaaaatg gcctaccagg aatacccaaa tagccagaac tggccagaag ataccaactt      900

ttgtttccaa cctgagcaag tggtcgatcc tatccagact gatcccttta agatgtacca      960

tgatgatgac ctggcagatt tggtctttcc ctccagtgcg acagctgata cttcaatatt     1020

tgcaggacaa aatgatccct tgaaagacag ttacggtatg tctccctgca acacagctgt     1080

tgtacctcag gggtggtctg tggaagcctt aaactctcca cactcagagt cctttgtttc     1140

cccagaggct gttgcagaac ctcctcagcc aacggcagtt cccttagagc tagccaagga     1200

gatagaaatg gcatcagaag agaggccacc agcacaagca ttggaaataa tgatgggact     1260

gaagactact gacatggcac catctaaaga aacagagatg gccctcgcca aggacatggc     1320

actagctaca aaaaccgagg tggcattggc taaagatatg gaatcaccca ccaaattaga     1380

tgtgacactg gccaaggaca tgcagccatc catggaatca gatatggccc tagtcaagga     1440

catggaacta cccacagaaa aagaagtggc cctggttaag gatgtcagat ggcccacaga     1500

aacagatgta tcttcagcca agaatgtggt actgcccaca gaaacagagg tagccccagc     1560

caaggatgtg acactgttga aagaaacaga gagggcatct cctataaaaa tggacttagc     1620

cccttccaag gacatgggac cacccaaaga aaacaagaaa gaaacagaga gggcatctcc     1680

tataaaaatg gacttggctc cttccaagga catgggacca cccaaagaaa acaagatagt     1740

cccagccaag gatttggtat tactctcaga aatagaggtg gcacaggcta atgacattat     1800

atcatccaca gaaatatcct ctgctgagaa ggtggctttg tcctcagaaa cagaggtagc     1860

cctggccagg gacatgacac tgcccccgga aaccaacgtg atcttgacca aggataaagc     1920

actaccttta gaagcagagg tggccccagt caaggacatg gctcaactcc cagaaacaga     1980

aatagccccg gccaaggatg tggctccgtc cacagtaaaa gaagtgggct tgttgaagga     2040

catgtctcca ctatcagaaa cagaaatggc tctgggcaag gatgtgactc cacctccaga     2100

aacagaagta gttctcatca agaacgtatg tctgcctcca gaaatggagg tggccctgac     2160

tgaggatcag gtcccagccc tcaaaacaga agcacccctg gctaaggatg gggttctgac     2220

cctggccaac aatgtgactc cagccaaaga tgttccacca ctctcagaaa cagaggcaac     2280

accagttcca attaaagaca tggaaattgc acaaacacaa aaaggaataa gtgaggattc     2340

ccatttagaa tctctgcagg atgtggggca gtcagctgca cctactttca tgatttcacc     2400

agaaaccgtc acaggaacgg ggaaaaagtg cagcttgccg gccgaggagg attctgtgtt     2460

agaaaaacta ggggaaagga aaccatgcaa cagtcaacct tctgagcttt cttcagagac     2520

ctcaggaata gccaggccag aagaaggaag gcctgtggtg agtgggacag gaaatgacat     2580

caccacccca ccgaacaagg agctcccacc aagcccagag aagaaaacaa agcctttggc     2640

caccactcaa cctgcaaaga cttcaacatc gaaagccaaa acacagccca cttctctccc     2700

taagcagcca gctcccacca ccattggtgg gttgaataaa aaacccatga gccttgcttc     2760

aggcttagtg ccagctgccc cacccaaacg ccctgccgtc gcctctgcca ggccttccat     2820

cttaccttca aaagacgtga agccaaagcc cattgcagat gcaaaggctc ctgagaagcg     2880

ggcctcacca tccaagccag cttctgcccc agcctccaga tctgggtcca agagcactca     2940

gactgttgca aaaaccacaa cagctgctgc tgttgcctca actggcccaa gcagtaggag     3000

cccctccacg ctcctgccca agaagcccac tgccattaag actgagggaa aacctgcaga     3060

agtcaagaag atgactgcaa agtctgtacc agctgacttg agtcgcccaa agagcacctc     3120

caccagttcc atgaagaaaa ccaccactct cagtgggaca gcccccgctg caggggtggt     3180

tcccagccga gtcaaggcca cacccatgcc ctcccggccc tccacaactc ctttcataga     3240

caagaagccc acctcggcca aacccagctc caccaccccc cggctcagcc gcctggccac     3300

caatacttct gctcctgatc tgaagaatgt ccgctccaag gttggctcca cggaaaacat     3360

caagcatcag cctggaggag gccgggccaa agtagagaaa aaaacagagg cagctgctac     3420

aacccgaaag cctgaatcta atgcagtcac taaaacagcc ggcccaattg caagtgcaca     3480

gaaacaacct gcggggaaag tccagatagt ctccaaaaaa gtgagctaca gccatattca     3540

gtccaagtgt ggttccaagg acaatattaa gcatgtccct ggaggtggta atgttcagat     3600

tcagaacaag aaagtggaca tctctaaggt ctcctccaag tgtgggtcta aggctaacat     3660

caagcacaag cctggtggag gagatgtcaa gattgaaagt cagaagttga acttcaagga     3720

gaaggcccag gccaaggtgg gatccctcga taatgtgggc cacctacctg caggaggtgc     3780

tgtgaagatt gagacctaca ggctgacgtt ccgggcaaat gccagggccc gcaccgacca     3840

cggggccgac attgtctccc gccccccaca cttccctggc ggccccaact cgggctcccg     3900

ggtccttggc cccctttccc gggctgtcca ctagaccagt gagcgcttgg gcgccgtgct     3960

gggcagcccg ctaggctcgc cttccctcct gctttgcgtg cccggggcag cagcagccct     4020

gccccacacc tcctctcact ccccagcctg ggcccatctc cctgctttgg tcttgcccca     4080

tcactgcgcc actgctccgt ggaggaggtt gggagggggt tggggtggtt gaggctaagt     4140

tgggatctag gagaggagaa ccagattcta tcctcatctt tttttggttc tttggtccaa     4200

acccaaaaga aactgacatg ccctcccttc tccctggatc tacctggagg gaagagtgga     4260

ggtggattcc gagtggtgac aggacgctga ccgtggagct taagccactg cctctccctc     4320

tggtcccaca aatgggcgcc cccccctccc catgcaggtg gtgtcgggcc cttcttgctg     4380

ccctgcccca agttgggggt cagtgctgcc tgtccccatg cttaacatac ccgcctagct     4440

gctgtcacat ttttcttgtt ttgtcctttt atttttttct aataacctaa aaactggcaa     4500

aatagttctg caggttgaag ccatgtctac atgaaagtcc tcagtaagtg ttagagggaa     4560

cagggcggag atatccttat gccacccccg ctggaggatg tgggcagctt agggccctgg     4620

aggcggtgcg gcagggaaga ggggtgcaga ggctgtggct ggtgagccgg tcaggcacac     4680

aaggggccct tggagcgtgg actggttggt tttgccattt tgttgtgtgt atgctgcttt     4740

tcttttctaa ccaagaggct ggttttggca tctctgtccc attccctggg atctggtggt     4800

cagccctagg ataaaaagcc agggctggag aacaagaaag ggccaggaga tggaattcct     4860

tcaggccggc acccacaccc taggacatgt aagccctcat gtccaaggga gcctcatgca     4920

gatagtagga aatcaggtct ggaaatttaa aaataaaagg catgagacta aggctatctg     4980

cttcccttat gccctgactg gagaggggag ggaggagagg caaggcccac agagggcatc     5040

ccagctaggc cttgggatgg ctgcagtgag gagaaatccc gggaactgta ttgacacaaa     5100

gattcttatt gcacttgtat tttttgtatt aaagtttgca tggtttctaa taaaggattc     5160

aaacataagt ttgtagtgaa atggcctggg agattccaag ggcttctctg gagggggatt     5220

ggctgcagtg tagatttgcc tctgaggagg ctgccccaga cttggcctcc tcatgccccc     5280

tcctgacctc tgcccttctc tggtcctggc atccctggag aaggtagggg tcttgaccta     5340

agtttagatt tgatctccat gtgcagggag gctgtcctgg gcctgacagg tcctccccct     5400

ttctgaggta gcagtgcctt gtggaggttt gacaccatgt ccctagctcc ccaagcacac     5460

accaggaaac tgcaggggct cacggaggaa gtgctgcctg ggccaggggg accagctttc     5520

ctccgtagag accatgtgca gaacacttct gctgtgccaa gaacatgagg gagccagtgt     5580

tttgtcagca ggaagaaagg gcctgctggg atgaaagtgg gaaggaaaca gggttgcgta     5640

gtcaggagac acctcagggg caacagcaca ggcccagagt acctgctgcc tccactgcgt     5700

ctgtcctggg gtcatgagga tgctgaggtt gacgacaggt tccaggtcct ttcactcctt     5760

tggccaaagg ttgggggtag gtggcccaag tggcgtgctc tctaggtaga caacaggagt     5820

ggtcagagtt ccctcaaagg atcctccact ccagagcacc tgagaaggcc gggaccagag     5880

gccctgtgtg atgtgtactc cgcagctgtt tggggtggga catttctgta cttctcgatt     5940

tgcttatggc tcagccatta cctgtgtcag tccatgattc tgttgtaaca gttttaagag     6000

taaataaata aagctgcctg atgtcccatc acgcagaaaa aaaaaa                    6046


<210>  198
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr Glu Pro Ser Pro Asp 
1               5                   10                  15      


Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala Thr Leu Glu Ala Glu 
            20                  25                  30          


Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly Lys Thr Asp Tyr Ile 
        35                  40                  45              


Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn Ser Glu Ser Lys Lys 
    50                  55                  60                  


Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp Thr Pro Ser Ser Lys 
65                  70                  75                  80  


Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val Glu Gly Ser Asp Thr 
                85                  90                  95      


Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys Met Ala Tyr Gln Glu 
            100                 105                 110         


Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr Asn Phe Cys Phe Gln 
        115                 120                 125             


Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp Pro Phe Lys Met Tyr 
    130                 135                 140                 


His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro Ser Ser Ala Thr Ala 
145                 150                 155                 160 


Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro Leu Lys Asp Ser Tyr 
                165                 170                 175     


Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro Gln Gly Trp Ser Val 
            180                 185                 190         


Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe Val Ser Pro Glu Ala 
        195                 200                 205             


Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro Leu Glu Leu Ala Lys 
    210                 215                 220                 


Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro Ala Gln Ala Leu Glu 
225                 230                 235                 240 


Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala Pro Ser Lys Glu Thr 
                245                 250                 255     


Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala Thr Lys Thr Glu Val 
            260                 265                 270         


Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys Leu Asp Val Thr Leu 
        275                 280                 285             


Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp Met Ala Leu Val Lys 
    290                 295                 300                 


Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala Leu Val Lys Asp Val 
305                 310                 315                 320 


Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala Lys Asn Val Val Leu 
                325                 330                 335     


Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp Val Thr Leu Leu Lys 
            340                 345                 350         


Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu Thr Glu Arg Ala Ser 
    370                 375                 380                 


Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys 
385                 390                 395                 400 


Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val Leu Leu Ser Glu Ile 
                405                 410                 415     


Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser Thr Glu Ile Ser Ser 
            420                 425                 430         


Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu Val Ala Leu Ala Arg 
        435                 440                 445             


Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile Leu Thr Lys Asp Lys 
    450                 455                 460                 


Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val Lys Asp Met Ala Gln 
465                 470                 475                 480 


Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp Val Ala Pro Ser Thr 
                485                 490                 495     


Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser Pro Leu Ser Glu Thr 
            500                 505                 510         


Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro Pro Glu Thr Glu Val 
        515                 520                 525             


Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu Met Glu Val Ala Leu 
    530                 535                 540                 


Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu Ala Pro Leu Ala Lys 
545                 550                 555                 560 


Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr Pro Ala Lys Asp Val 
                565                 570                 575     


Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val Pro Ile Lys Asp Met 
            580                 585                 590         


Glu Ile Ala Gln Thr Gln Lys Gly Ile Ser Glu Asp Ser His Leu Glu 
        595                 600                 605             


Ser Leu Gln Asp Val Gly Gln Ser Ala Ala Pro Thr Phe Met Ile Ser 
    610                 615                 620                 


Pro Glu Thr Val Thr Gly Thr Gly Lys Lys Cys Ser Leu Pro Ala Glu 
625                 630                 635                 640 


Glu Asp Ser Val Leu Glu Lys Leu Gly Glu Arg Lys Pro Cys Asn Ser 
                645                 650                 655     


Gln Pro Ser Glu Leu Ser Ser Glu Thr Ser Gly Ile Ala Arg Pro Glu 
            660                 665                 670         


Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn Asp Ile Thr Thr Pro 
        675                 680                 685             


Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys Lys Thr Lys Pro Leu 
    690                 695                 700                 


Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser Lys Ala Lys Thr Gln 
705                 710                 715                 720 


Pro Thr Ser Leu Pro Lys Gln Pro Ala Pro Thr Thr Ile Gly Gly Leu 
                725                 730                 735     


Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu Val Pro Ala Ala Pro 
            740                 745                 750         


Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro Ser Ile Leu Pro Ser 
        755                 760                 765             


Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala Lys Ala Pro Glu Lys 
    770                 775                 780                 


Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro Ala Ser Arg Ser Gly 
785                 790                 795                 800 


Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr Thr Ala Ala Ala Val 
                805                 810                 815     


Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser Thr Leu Leu Pro Lys 
            820                 825                 830         


Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro Ala Glu Val Lys Lys 
        835                 840                 845             


Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser Arg Pro Lys Ser Thr 
    850                 855                 860                 


Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu Ser Gly Thr Ala Pro 
865                 870                 875                 880 


Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala Thr Pro Met Pro Ser 
                885                 890                 895     


Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys Pro Thr Ser Ala Lys 
            900                 905                 910         


Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu Ala Thr Asn Thr Ser 
        915                 920                 925             


Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val Gly Ser Thr Glu Asn 
    930                 935                 940                 


Ile Lys His Gln Pro Gly Gly Gly Arg Ala Lys Val Glu Lys Lys Thr 
945                 950                 955                 960 


Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu Ser Asn Ala Val Thr Lys 
                965                 970                 975     


Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys Gln Pro Ala Gly Lys Val 
            980                 985                 990         


Gln Ile Val Ser Lys Lys Val Ser  Tyr Ser His Ile Gln  Ser Lys Cys 
        995                 1000                 1005             


Gly Ser  Lys Asp Asn Ile Lys  His Val Pro Gly Gly  Gly Asn Val 
    1010                 1015                 1020             


Gln Ile  Gln Asn Lys Lys Val  Asp Ile Ser Lys Val  Ser Ser Lys 
    1025                 1030                 1035             


Cys Gly  Ser Lys Ala Asn Ile  Lys His Lys Pro Gly  Gly Gly Asp 
    1040                 1045                 1050             


Val Lys  Ile Glu Ser Gln Lys  Leu Asn Phe Lys Glu  Lys Ala Gln 
    1055                 1060                 1065             


Ala Lys  Val Gly Ser Leu Asp  Asn Val Gly His Leu  Pro Ala Gly 
    1070                 1075                 1080             


Gly Ala  Val Lys Ile Glu Thr  Tyr Arg Leu Thr Phe  Arg Ala Asn 
    1085                 1090                 1095             


Ala Arg  Ala Arg Thr Asp His  Gly Ala Asp Ile Val  Ser Arg Pro 
    1100                 1105                 1110             


Pro His  Phe Pro Gly Gly Pro  Asn Ser Gly Ser Arg  Val Leu Gly 
    1115                 1120                 1125             


Pro Leu  Ser Arg Ala Val His  
    1130                 1135 


<210>  199
<211>  4855
<212>  DNA
<213>  Homo sapiens

<400>  199
aagacagatg cagccaatag atacactgca gtggctgaca aaccaagtaa aaggagtaat       60

gatggaaaaa gtaaaaaggt taaaaatagt tctcctgaga agcacattct ggagaataag      120

atagatgcaa caaaaataca tgttcccatg gaaaccacag gggaccaggg aattgaagga      180

atggcctata tggacgaaaa tagaaatatt acatttacct gtcccagaac accatcagag      240

ctgataaata aatcatctcc tctagaggtt ctggaatcag cagcctgtga aaaactgccc      300

actcctactc ctcaagtagt aaaggaaggt gattcctttc cagatacctt ggcaaaaaat      360

gggcaagaga tagccccagc ccagatttcc aaatcattaa tggtagataa ctacaccaaa      420

gatggagtcc caggtcaaga aagacccaag ggtccctctg ctgttgtgcc ctctacaagc      480

acaggaggag ttgctctacc tattacaaca gccatagaaa cagttaacat tcatggagat      540

cactctctta agaataaagc tgagcttgct gattccatga aaaatgaagc agggatcgat      600

gaagggcatg tgataggaga atctgagtca gtgcacagtg gtgcgtctaa gcattcagta      660

gagaaagtca cagagctagc aaaaggtcac ctccttcctg gagtgccagt agaagaccag      720

agcctaccag gagaggccag agccctagaa ggatatgcag atagaggtaa tttcccagca      780

catccagtga atgaagagaa agagactaaa gaagggtctg ttgcagttca gattcctgac      840

ttactggaag acaaagcaca aaagctcagt ttttgtgagg accaaaatgc tcaagataga      900

aattccaaag gttcagatag tttgaataag aaggtagatc tgactctttt gtctccaaaa      960

agtgaaaatg ataaattgaa agaaattagt ctggcttgta aaatcacgga attggaaagc     1020

gtttccttgc caacaccaga aatccagtca gatttcttac atagcaaagt cgaagctcct     1080

ccttcagagg tggcggatac gttagtaata atgactgctt ccaagggtgt tcgactccca     1140

gaacccaaag ataagatttt ggagacacct cagaaaatga cagaaaaatc tgaatcaaag     1200

acaccaggag aagggaaaaa ggaagataaa agcagaatgg cagaaccaat gaaaggctac     1260

atgagaccca ccaagtcccg aggacttact ccacttttgc caaagtctac aatccaggaa     1320

caagagagac ataagcaact gaagtccgct ggaatagcca ggccagaaga aggaaggcct     1380

gtggtgagtg ggacaggaaa tgacatcacc accccaccga acaaggagct cccaccaagc     1440

ccagagaaga aaacaaagcc tttggccacc actcaacctg caaagacttc aacatcgaaa     1500

gccaaaacac agcccacttc tctccctaag cagccagctc ccaccaccat tggtgggttg     1560

aataaaaaac ccatgagcct tgcttcaggc ttagtgccag ctgccccacc caaacgccct     1620

gccgtcgcct ctgccaggcc ttccatctta ccttcaaaag acgtgaagcc aaagcccatt     1680

gcagatgcaa aggctcctga gaagcgggcc tcaccatcca agccagcttc tgccccagcc     1740

tccagatctg ggtccaagag cactcagact gttgcaaaaa ccacaacagc tgctgctgtt     1800

gcctcaactg gcccaagcag taggagcccc tccacgctcc tgcccaagaa gcccactgcc     1860

attaagactg agggaaaacc tgcagaagtc aagaagatga ctgcaaagtc tgtaccagct     1920

gacttgagtc gcccaaagag cacctccacc agttccatga agaaaaccac cactctcagt     1980

gggacagccc ccgctgcagg ggtggttccc agccgagtca aggccacacc catgccctcc     2040

cggccctcca caactccttt catagacaag aagcccacct cggccaaacc cagctccacc     2100

accccccggc tcagccgcct ggccaccaat acttctgctc ctgatctgaa gaatgtccgc     2160

tccaaggttg gctccacgga aaacatcaag catcagcctg gaggaggccg ggttcagatt     2220

cagaacaaga aagtggacat ctctaaggtc tcctccaagt gtgggtctaa ggctaacatc     2280

aagcacaagc ctggtggagg agatgtcaag attgaaagtc agaagttgaa cttcaaggag     2340

aaggcccagg ccaaggtggg atccctcgat aatgtgggcc acctacctgc aggaggtgct     2400

gtgaagactg agggcggtgg cagcgaggct cctctgtgtc cgggtccccc tgctggggag     2460

gagccggcca tctctgaggc agcgcctgaa gctggcgccc ccacttcagc cagtggcctc     2520

aatggccacc ccaccctgtc agggggtggt gaccaaaggg aggcccagac cttggacagc     2580

cagatccagg agacaaattg agacctacag gctgacgttc cgggcaaatg ccagggcccg     2640

caccgaccac ggggccgaca ttgtctcccg ccccccacac ttccctggcg gccccaactc     2700

gggctcccgg gtccttggcc ccctttcccg ggctgtccac tagaccagtg agcgcttggg     2760

cgccgtgctg ggcagcccgc taggctcgcc ttccctcctg ctttgcgtgc ccggggcagc     2820

agcagccctg ccccacacct cctctcactc cccagcctgg gcccatctcc ctgctttggt     2880

cttgccccat cactgcgcca ctgctccgtg gaggaggttg ggagggggtt ggggtggttg     2940

aggctaagtt gggatctagg agaggagaac cagattctat cctcatcttt ttttggttct     3000

ttggtccaaa cccaaaagaa actgacatgc cctcccttct ccctggatct acctggaggg     3060

aagagtggag gtggattccg agtggtgaca ggacgctgac cgtggagctt aagccactgc     3120

ctctccctct ggtcccacaa atgggcgccc ccccctcccc atgcaggtgg tgtcgggccc     3180

ttcttgctgc cctgccccaa gttgggggtc agtgctgcct gtccccatgc ttaacatacc     3240

cgcctagctg ctgtcacatt tttcttgttt tgtcctttta tttttttcta ataacctaaa     3300

aactggcaaa atagttctgc aggttgaagc catgtctaca tgaaagtcct cagtaagtgt     3360

tagagggaac agggcggaga tatccttatg ccacccccgc tggaggatgt gggcagctta     3420

gggccctgga ggcggtgcgg cagggaagag gggtgcagag gctgtggctg gtgagccggt     3480

caggcacaca aggggccctt ggagcgtgga ctggttggtt ttgccatttt gttgtgtgta     3540

tgctgctttt cttttctaac caagaggctg gttttggcat ctctgtccca ttccctggga     3600

tctggtggtc agccctagga taaaaagcca gggctggaga acaagaaagg gccaggagat     3660

ggaattcctt caggccggca cccacaccct aggacatgta agccctcatg tccaagggag     3720

cctcatgcag atagtaggaa atcaggtctg gaaatttaaa aataaaaggc atgagactaa     3780

ggctatctgc ttcccttatg ccctgactgg agaggggagg gaggagaggc aaggcccaca     3840

gagggcatcc cagctaggcc ttgggatggc tgcagtgagg agaaatcccg ggaactgtat     3900

tgacacaaag attcttattg cacttgtatt ttttgtatta aagtttgcat ggtttctaat     3960

aaaggattca aacataagtt tgtagtgaaa tggcctggga gattccaagg gcttctctgg     4020

agggggattg gctgcagtgt agatttgcct ctgaggaggc tgccccagac ttggcctcct     4080

catgccccct cctgacctct gcccttctct ggtcctggca tccctggaga aggtaggggt     4140

cttgacctaa gtttagattt gatctccatg tgcagggagg ctgtcctggg cctgacaggt     4200

cctccccctt tctgaggtag cagtgccttg tggaggtttg acaccatgtc cctagctccc     4260

caagcacaca ccaggaaact gcaggggctc acggaggaag tgctgcctgg gccaggggga     4320

ccagctttcc tccgtagaga ccatgtgcag aacacttctg ctgtgccaag aacatgaggg     4380

agccagtgtt ttgtcagcag gaagaaaggg cctgctggga tgaaagtggg aaggaaacag     4440

ggttgcgtag tcaggagaca cctcaggggc aacagcacag gcccagagta cctgctgcct     4500

ccactgcgtc tgtcctgggg tcatgaggat gctgaggttg acgacaggtt ccaggtcctt     4560

tcactccttt ggccaaaggt tgggggtagg tggcccaagt ggcgtgctct ctaggtagac     4620

aacaggagtg gtcagagttc cctcaaagga tcctccactc cagagcacct gagaaggccg     4680

ggaccagagg ccctgtgtga tgtgtactcc gcagctgttt ggggtgggac atttctgtac     4740

ttctcgattt gcttatggct cagccattac ctgtgtcagt ccatgattct gttgtaacag     4800

ttttaagagt aaataaataa agctgcctga tgtcccatca cgcagaaaaa aaaaa          4855


<210>  200
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Glu Thr Thr Gly Asp Gln Gly Ile Glu Gly Met Ala Tyr Met Asp 
1               5                   10                  15      


Glu Asn Arg Asn Ile Thr Phe Thr Cys Pro Arg Thr Pro Ser Glu Leu 
            20                  25                  30          


Ile Asn Lys Ser Ser Pro Leu Glu Val Leu Glu Ser Ala Ala Cys Glu 
        35                  40                  45              


Lys Leu Pro Thr Pro Thr Pro Gln Val Val Lys Glu Gly Asp Ser Phe 
    50                  55                  60                  


Pro Asp Thr Leu Ala Lys Asn Gly Gln Glu Ile Ala Pro Ala Gln Ile 
65                  70                  75                  80  


Ser Lys Ser Leu Met Val Asp Asn Tyr Thr Lys Asp Gly Val Pro Gly 
                85                  90                  95      


Gln Glu Arg Pro Lys Gly Pro Ser Ala Val Val Pro Ser Thr Ser Thr 
            100                 105                 110         


Gly Gly Val Ala Leu Pro Ile Thr Thr Ala Ile Glu Thr Val Asn Ile 
        115                 120                 125             


His Gly Asp His Ser Leu Lys Asn Lys Ala Glu Leu Ala Asp Ser Met 
    130                 135                 140                 


Lys Asn Glu Ala Gly Ile Asp Glu Gly His Val Ile Gly Glu Ser Glu 
145                 150                 155                 160 


Ser Val His Ser Gly Ala Ser Lys His Ser Val Glu Lys Val Thr Glu 
                165                 170                 175     


Leu Ala Lys Gly His Leu Leu Pro Gly Val Pro Val Glu Asp Gln Ser 
            180                 185                 190         


Leu Pro Gly Glu Ala Arg Ala Leu Glu Gly Tyr Ala Asp Arg Gly Asn 
        195                 200                 205             


Phe Pro Ala His Pro Val Asn Glu Glu Lys Glu Thr Lys Glu Gly Ser 
    210                 215                 220                 


Val Ala Val Gln Ile Pro Asp Leu Leu Glu Asp Lys Ala Gln Lys Leu 
225                 230                 235                 240 


Ser Phe Cys Glu Asp Gln Asn Ala Gln Asp Arg Asn Ser Lys Gly Ser 
                245                 250                 255     


Asp Ser Leu Asn Lys Lys Val Asp Leu Thr Leu Leu Ser Pro Lys Ser 
            260                 265                 270         


Glu Asn Asp Lys Leu Lys Glu Ile Ser Leu Ala Cys Lys Ile Thr Glu 
        275                 280                 285             


Leu Glu Ser Val Ser Leu Pro Thr Pro Glu Ile Gln Ser Asp Phe Leu 
    290                 295                 300                 


His Ser Lys Val Glu Ala Pro Pro Ser Glu Val Ala Asp Thr Leu Val 
305                 310                 315                 320 


Ile Met Thr Ala Ser Lys Gly Val Arg Leu Pro Glu Pro Lys Asp Lys 
                325                 330                 335     


Ile Leu Glu Thr Pro Gln Lys Met Thr Glu Lys Ser Glu Ser Lys Thr 
            340                 345                 350         


Pro Gly Glu Gly Lys Lys Glu Asp Lys Ser Arg Met Ala Glu Pro Met 
        355                 360                 365             


Lys Gly Tyr Met Arg Pro Thr Lys Ser Arg Gly Leu Thr Pro Leu Leu 
    370                 375                 380                 


Pro Lys Ser Thr Ile Gln Glu Gln Glu Arg His Lys Gln Leu Lys Ser 
385                 390                 395                 400 


Ala Gly Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr 
                405                 410                 415     


Gly Asn Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro 
            420                 425                 430         


Glu Lys Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser 
        435                 440                 445             


Thr Ser Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala 
    450                 455                 460                 


Pro Thr Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser 
465                 470                 475                 480 


Gly Leu Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala 
                485                 490                 495     


Arg Pro Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala 
            500                 505                 510         


Asp Ala Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser 
        515                 520                 525             


Ala Pro Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys 
    530                 535                 540                 


Thr Thr Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser 
545                 550                 555                 560 


Pro Ser Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly 
                565                 570                 575     


Lys Pro Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp 
            580                 585                 590         


Leu Ser Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr 
        595                 600                 605             


Thr Leu Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val 
    610                 615                 620                 


Lys Ala Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp 
625                 630                 635                 640 


Lys Lys Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser 
                645                 650                 655     


Arg Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser 
            660                 665                 670         


Lys Val Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg 
        675                 680                 685             


Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser Lys 
    690                 695                 700                 


Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp Val 
705                 710                 715                 720 


Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala Lys 
                725                 730                 735     


Val Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala Val 
            740                 745                 750         


Lys Thr Glu Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro Gly Pro Pro 
        755                 760                 765             


Ala Gly Glu Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu Ala Gly Ala 
    770                 775                 780                 


Pro Thr Ser Ala Ser Gly Leu Asn Gly His Pro Thr Leu Ser Gly Gly 
785                 790                 795                 800 


Gly Asp Gln Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile Gln Glu Thr 
                805                 810                 815     


Asn 
    


<210>  201
<211>  6337
<212>  DNA
<213>  Homo sapiens

<400>  201
aggccccacc cgctggtggc ccggtccgcg tgtgcgccga ctctcgcact ctcctcgctc       60

cgggcgccca gactctgaga gagagcgacg gccatcatag aacagcgaag gcagtcgatc      120

ggcctgcggt ccgcttcggc attcgcaggc cgcaggcggg aggctagagc ccccaggcgc      180

acctcgcccc aaccgcccgc ggctcgggca gctctgcaga gacgtcgtgg cggcagggcc      240

agcacccatt ggtccgccac agccctccgc cctccccctc gccacgctta ttggccggag      300

cggcggcgct cgccgggtag gcggtggcgg cgtccctccc ttgcgccggc cctcaagagg      360

cgacgaggaa gcggccgcct ccctgcgccc cgcccctccg gctagctcgc tggctcccgg      420

ctcctcccga cgtctcctac ctcctcacgg ctcttcccgg cgctctcctg gctcccttct      480

gccccagctc cgtctcggcg gcggcgggca gttgcagtgg tgcagaatgg ctgacctcag      540

tcttgcagat gcattaacag aaccatctcc agacattgag ggagagataa agcgggactt      600

cattgccaca ctagaggcag aggcctttga tgatgttgtg ggagaaactg ttggaaaaac      660

agactatatt cctctcctgg atgttgatga gaaaaccggg aactcagagt caaagaagaa      720

accgtgctca gaaactagcc agattgaaga tactccatct tctaaaccaa cactcctagc      780

caatggtggt catggagtag aagggagcga tactacaggg tctccaactg aattccttga      840

agagaaaatg gcctaccagg aatacccaaa tagccagaac tggccagaag ataccaactt      900

ttgtttccaa cctgagcaag tggtcgatcc tatccagact gatcccttta agatgtacca      960

tgatgatgac ctggcagatt tggtctttcc ctccagtgcg acagctgata cttcaatatt     1020

tgcaggacaa aatgatccct tgaaagacag ttacggtatg tctccctgca acacagctgt     1080

tgtacctcag gggtggtctg tggaagcctt aaactctcca cactcagagt cctttgtttc     1140

cccagaggct gttgcagaac ctcctcagcc aacggcagtt cccttagagc tagccaagga     1200

gatagaaatg gcatcagaag agaggccacc agcacaagca ttggaaataa tgatgggact     1260

gaagactact gacatggcac catctaaaga aacagagatg gccctcgcca aggacatggc     1320

actagctaca aaaaccgagg tggcattggc taaagatatg gaatcaccca ccaaattaga     1380

tgtgacactg gccaaggaca tgcagccatc catggaatca gatatggccc tagtcaagga     1440

catggaacta cccacagaaa aagaagtggc cctggttaag gatgtcagat ggcccacaga     1500

aacagatgta tcttcagcca agaatgtggt actgcccaca gaaacagagg tagccccagc     1560

caaggatgtg acactgttga aagaaacaga gagggcatct cctataaaaa tggacttagc     1620

cccttccaag gacatgggac cacccaaaga aaacaagaaa gaaacagaga gggcatctcc     1680

tataaaaatg gacttggctc cttccaagga catgggacca cccaaagaaa acaagatagt     1740

cccagccaag gatttggtat tactctcaga aatagaggtg gcacaggcta atgacattat     1800

atcatccaca gaaatatcct ctgctgagaa ggtggctttg tcctcagaaa cagaggtagc     1860

cctggccagg gacatgacac tgcccccgga aaccaacgtg atcttgacca aggataaagc     1920

actaccttta gaagcagagg tggccccagt caaggacatg gctcaactcc cagaaacaga     1980

aatagccccg gccaaggatg tggctccgtc cacagtaaaa gaagtgggct tgttgaagga     2040

catgtctcca ctatcagaaa cagaaatggc tctgggcaag gatgtgactc cacctccaga     2100

aacagaagta gttctcatca agaacgtatg tctgcctcca gaaatggagg tggccctgac     2160

tgaggatcag gtcccagccc tcaaaacaga agcacccctg gctaaggatg gggttctgac     2220

cctggccaac aatgtgactc cagccaaaga tgttccacca ctctcagaaa cagaggcaac     2280

accagttcca attaaagaca tggaaattgc acaaacacaa aaaggaataa gtgaggattc     2340

ccatttagaa tctctgcagg atgtggggca gtcagctgca cctactttca tgatttcacc     2400

agaaaccgtc acaggaacgg ggaaaaagtg cagcttgccg gccgaggagg attctgtgtt     2460

agaaaaacta ggggaaagga aaccatgcaa cagtcaacct tctgagcttt cttcagagac     2520

ctcaggaata gccaggccag aagaaggaag gcctgtggtg agtgggacag gaaatgacat     2580

caccacccca ccgaacaagg agctcccacc aagcccagag aagaaaacaa agcctttggc     2640

caccactcaa cctgcaaaga cttcaacatc gaaagccaaa acacagccca cttctctccc     2700

taagcagcca gctcccacca ccattggtgg gttgaataaa aaacccatga gccttgcttc     2760

aggcttagtg ccagctgccc cacccaaacg ccctgccgtc gcctctgcca ggccttccat     2820

cttaccttca aaagacgtga agccaaagcc cattgcagat gcaaaggctc ctgagaagcg     2880

ggcctcacca tccaagccag cttctgcccc agcctccaga tctgggtcca agagcactca     2940

gactgttgca aaaaccacaa cagctgctgc tgttgcctca actggcccaa gcagtaggag     3000

cccctccacg ctcctgccca agaagcccac tgccattaag actgagggaa aacctgcaga     3060

agtcaagaag atgactgcaa agtctgtacc agctgacttg agtcgcccaa agagcacctc     3120

caccagttcc atgaagaaaa ccaccactct cagtgggaca gcccccgctg caggggtggt     3180

tcccagccga gtcaaggcca cacccatgcc ctcccggccc tccacaactc ctttcataga     3240

caagaagccc acctcggcca aacccagctc caccaccccc cggctcagcc gcctggccac     3300

caatacttct gctcctgatc tgaagaatgt ccgctccaag gttggctcca cggaaaacat     3360

caagcatcag cctggaggag gccgggccaa agtagagaaa aaaacagagg cagctgctac     3420

aacccgaaag cctgaatcta atgcagtcac taaaacagcc ggcccaattg caagtgcaca     3480

gaaacaacct gcggggaaag tccagatagt ctccaaaaaa gtgagctaca gccatattca     3540

gtccaagtgt ggttccaagg acaatattaa gcatgtccct ggaggtggta atgttcagat     3600

tcagaacaag aaagtggaca tctctaaggt ctcctccaag tgtgggtcta aggctaacat     3660

caagcacaag cctggtggag gagatgtcaa gattgaaagt cagaagttga acttcaagga     3720

gaaggcccag gccaaggtgg gatccctcga taatgtgggc cacctacctg caggaggtgc     3780

tgtgaagact gagggcggtg gcagcgaggc tcctctgtgt ccgggtcccc ctgctgggga     3840

ggagccggcc atctctgagg cagcgcctga agctggcgcc cccacttcag ccagtggcct     3900

caatggccac cccaccctgt cagggggtgg tgaccaaagg gaggcccaga ccttggacag     3960

ccagatccag gagacaagca tctaatgatg acattctggt ctcgtcttcc gtctcccccg     4020

tgttcccctc ttgtctcccc tgttcccctc tcccttccct cctcccatgt cactgcagat     4080

tgagacctac aggctgacgt tccgggcaaa tgccagggcc cgcaccgacc acggggccga     4140

cattgtctcc cgccccccac acttccctgg cggccccaac tcgggctccc gggtccttgg     4200

ccccctttcc cgggctgtcc actagaccag tgagcgcttg ggcgccgtgc tgggcagccc     4260

gctaggctcg ccttccctcc tgctttgcgt gcccggggca gcagcagccc tgccccacac     4320

ctcctctcac tccccagcct gggcccatct ccctgctttg gtcttgcccc atcactgcgc     4380

cactgctccg tggaggaggt tgggaggggg ttggggtggt tgaggctaag ttgggatcta     4440

ggagaggaga accagattct atcctcatct ttttttggtt ctttggtcca aacccaaaag     4500

aaactgacat gccctccctt ctccctggat ctacctggag ggaagagtgg aggtggattc     4560

cgagtggtga caggacgctg accgtggagc ttaagccact gcctctccct ctggtcccac     4620

aaatgggcgc ccccccctcc ccatgcaggt ggtgtcgggc ccttcttgct gccctgcccc     4680

aagttggggg tcagtgctgc ctgtccccat gcttaacata cccgcctagc tgctgtcaca     4740

tttttcttgt tttgtccttt tatttttttc taataaccta aaaactggca aaatagttct     4800

gcaggttgaa gccatgtcta catgaaagtc ctcagtaagt gttagaggga acagggcgga     4860

gatatcctta tgccaccccc gctggaggat gtgggcagct tagggccctg gaggcggtgc     4920

ggcagggaag aggggtgcag aggctgtggc tggtgagccg gtcaggcaca caaggggccc     4980

ttggagcgtg gactggttgg ttttgccatt ttgttgtgtg tatgctgctt ttcttttcta     5040

accaagaggc tggttttggc atctctgtcc cattccctgg gatctggtgg tcagccctag     5100

gataaaaagc cagggctgga gaacaagaaa gggccaggag atggaattcc ttcaggccgg     5160

cacccacacc ctaggacatg taagccctca tgtccaaggg agcctcatgc agatagtagg     5220

aaatcaggtc tggaaattta aaaataaaag gcatgagact aaggctatct gcttccctta     5280

tgccctgact ggagagggga gggaggagag gcaaggccca cagagggcat cccagctagg     5340

ccttgggatg gctgcagtga ggagaaatcc cgggaactgt attgacacaa agattcttat     5400

tgcacttgta ttttttgtat taaagtttgc atggtttcta ataaaggatt caaacataag     5460

tttgtagtga aatggcctgg gagattccaa gggcttctct ggagggggat tggctgcagt     5520

gtagatttgc ctctgaggag gctgccccag acttggcctc ctcatgcccc ctcctgacct     5580

ctgcccttct ctggtcctgg catccctgga gaaggtaggg gtcttgacct aagtttagat     5640

ttgatctcca tgtgcaggga ggctgtcctg ggcctgacag gtcctccccc tttctgaggt     5700

agcagtgcct tgtggaggtt tgacaccatg tccctagctc cccaagcaca caccaggaaa     5760

ctgcaggggc tcacggagga agtgctgcct gggccagggg gaccagcttt cctccgtaga     5820

gaccatgtgc agaacacttc tgctgtgcca agaacatgag ggagccagtg ttttgtcagc     5880

aggaagaaag ggcctgctgg gatgaaagtg ggaaggaaac agggttgcgt agtcaggaga     5940

cacctcaggg gcaacagcac aggcccagag tacctgctgc ctccactgcg tctgtcctgg     6000

ggtcatgagg atgctgaggt tgacgacagg ttccaggtcc tttcactcct ttggccaaag     6060

gttgggggta ggtggcccaa gtggcgtgct ctctaggtag acaacaggag tggtcagagt     6120

tccctcaaag gatcctccac tccagagcac ctgagaaggc cgggaccaga ggccctgtgt     6180

gatgtgtact ccgcagctgt ttggggtggg acatttctgt acttctcgat ttgcttatgg     6240

ctcagccatt acctgtgtca gtccatgatt ctgttgtaac agttttaaga gtaaataaat     6300

aaagctgcct gatgtcccat cacgcagaaa aaaaaaa                              6337


<210>  202
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr Glu Pro Ser Pro Asp 
1               5                   10                  15      


Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala Thr Leu Glu Ala Glu 
            20                  25                  30          


Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly Lys Thr Asp Tyr Ile 
        35                  40                  45              


Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn Ser Glu Ser Lys Lys 
    50                  55                  60                  


Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp Thr Pro Ser Ser Lys 
65                  70                  75                  80  


Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val Glu Gly Ser Asp Thr 
                85                  90                  95      


Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys Met Ala Tyr Gln Glu 
            100                 105                 110         


Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr Asn Phe Cys Phe Gln 
        115                 120                 125             


Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp Pro Phe Lys Met Tyr 
    130                 135                 140                 


His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro Ser Ser Ala Thr Ala 
145                 150                 155                 160 


Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro Leu Lys Asp Ser Tyr 
                165                 170                 175     


Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro Gln Gly Trp Ser Val 
            180                 185                 190         


Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe Val Ser Pro Glu Ala 
        195                 200                 205             


Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro Leu Glu Leu Ala Lys 
    210                 215                 220                 


Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro Ala Gln Ala Leu Glu 
225                 230                 235                 240 


Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala Pro Ser Lys Glu Thr 
                245                 250                 255     


Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala Thr Lys Thr Glu Val 
            260                 265                 270         


Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys Leu Asp Val Thr Leu 
        275                 280                 285             


Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp Met Ala Leu Val Lys 
    290                 295                 300                 


Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala Leu Val Lys Asp Val 
305                 310                 315                 320 


Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala Lys Asn Val Val Leu 
                325                 330                 335     


Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp Val Thr Leu Leu Lys 
            340                 345                 350         


Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu Thr Glu Arg Ala Ser 
    370                 375                 380                 


Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys 
385                 390                 395                 400 


Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val Leu Leu Ser Glu Ile 
                405                 410                 415     


Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser Thr Glu Ile Ser Ser 
            420                 425                 430         


Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu Val Ala Leu Ala Arg 
        435                 440                 445             


Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile Leu Thr Lys Asp Lys 
    450                 455                 460                 


Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val Lys Asp Met Ala Gln 
465                 470                 475                 480 


Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp Val Ala Pro Ser Thr 
                485                 490                 495     


Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser Pro Leu Ser Glu Thr 
            500                 505                 510         


Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro Pro Glu Thr Glu Val 
        515                 520                 525             


Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu Met Glu Val Ala Leu 
    530                 535                 540                 


Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu Ala Pro Leu Ala Lys 
545                 550                 555                 560 


Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr Pro Ala Lys Asp Val 
                565                 570                 575     


Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val Pro Ile Lys Asp Met 
            580                 585                 590         


Glu Ile Ala Gln Thr Gln Lys Gly Ile Ser Glu Asp Ser His Leu Glu 
        595                 600                 605             


Ser Leu Gln Asp Val Gly Gln Ser Ala Ala Pro Thr Phe Met Ile Ser 
    610                 615                 620                 


Pro Glu Thr Val Thr Gly Thr Gly Lys Lys Cys Ser Leu Pro Ala Glu 
625                 630                 635                 640 


Glu Asp Ser Val Leu Glu Lys Leu Gly Glu Arg Lys Pro Cys Asn Ser 
                645                 650                 655     


Gln Pro Ser Glu Leu Ser Ser Glu Thr Ser Gly Ile Ala Arg Pro Glu 
            660                 665                 670         


Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn Asp Ile Thr Thr Pro 
        675                 680                 685             


Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys Lys Thr Lys Pro Leu 
    690                 695                 700                 


Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser Lys Ala Lys Thr Gln 
705                 710                 715                 720 


Pro Thr Ser Leu Pro Lys Gln Pro Ala Pro Thr Thr Ile Gly Gly Leu 
                725                 730                 735     


Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu Val Pro Ala Ala Pro 
            740                 745                 750         


Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro Ser Ile Leu Pro Ser 
        755                 760                 765             


Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala Lys Ala Pro Glu Lys 
    770                 775                 780                 


Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro Ala Ser Arg Ser Gly 
785                 790                 795                 800 


Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr Thr Ala Ala Ala Val 
                805                 810                 815     


Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser Thr Leu Leu Pro Lys 
            820                 825                 830         


Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro Ala Glu Val Lys Lys 
        835                 840                 845             


Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser Arg Pro Lys Ser Thr 
    850                 855                 860                 


Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu Ser Gly Thr Ala Pro 
865                 870                 875                 880 


Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala Thr Pro Met Pro Ser 
                885                 890                 895     


Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys Pro Thr Ser Ala Lys 
            900                 905                 910         


Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu Ala Thr Asn Thr Ser 
        915                 920                 925             


Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val Gly Ser Thr Glu Asn 
    930                 935                 940                 


Ile Lys His Gln Pro Gly Gly Gly Arg Ala Lys Val Glu Lys Lys Thr 
945                 950                 955                 960 


Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu Ser Asn Ala Val Thr Lys 
                965                 970                 975     


Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys Gln Pro Ala Gly Lys Val 
            980                 985                 990         


Gln Ile Val Ser Lys Lys Val Ser  Tyr Ser His Ile Gln  Ser Lys Cys 
        995                 1000                 1005             


Gly Ser  Lys Asp Asn Ile Lys  His Val Pro Gly Gly  Gly Asn Val 
    1010                 1015                 1020             


Gln Ile  Gln Asn Lys Lys Val  Asp Ile Ser Lys Val  Ser Ser Lys 
    1025                 1030                 1035             


Cys Gly  Ser Lys Ala Asn Ile  Lys His Lys Pro Gly  Gly Gly Asp 
    1040                 1045                 1050             


Val Lys  Ile Glu Ser Gln Lys  Leu Asn Phe Lys Glu  Lys Ala Gln 
    1055                 1060                 1065             


Ala Lys  Val Gly Ser Leu Asp  Asn Val Gly His Leu  Pro Ala Gly 
    1070                 1075                 1080             


Gly Ala  Val Lys Thr Glu Gly  Gly Gly Ser Glu Ala  Pro Leu Cys 
    1085                 1090                 1095             


Pro Gly  Pro Pro Ala Gly Glu  Glu Pro Ala Ile Ser  Glu Ala Ala 
    1100                 1105                 1110             


Pro Glu  Ala Gly Ala Pro Thr  Ser Ala Ser Gly Leu  Asn Gly His 
    1115                 1120                 1125             


Pro Thr  Leu Ser Gly Gly Gly  Asp Gln Arg Glu Ala  Gln Thr Leu 
    1130                 1135                 1140             


Asp Ser  Gln Ile Gln Glu Thr  Ser Ile 
    1145                 1150         


<210>  203
<211>  5163
<212>  DNA
<213>  Homo sapiens

<400>  203
aagacagatg cagccaatag atacactgca gtggctgaca aaccaagtaa aaggagtaat       60

gatggaaaaa gtaaaaaggt taaaaatagt tctcctgaga agcacattct ggagaataag      120

atagatgcaa caaaaataca tgttcccatg gaaaccacag gggaccaggg aattgaagga      180

atggcctata tggacgaaaa tagaaatatt acatttacct gtcccagaac accatcagag      240

ctgataaata aatcatctcc tctagaggtt ctggaatcag cagcctgtga aaaactgccc      300

actcctactc ctcaagtagt aaaggaaggt gattcctttc cagatacctt ggcaaaaaat      360

gggcaagaga tagccccagc ccagatttcc aaatcattaa tggtagataa ctacaccaaa      420

gatggagtcc caggtcaaga aagacccaag ggtccctctg ctgttgtgcc ctctacaagc      480

acaggaggag ttgctctacc tattacaaca gccatagaaa cagttaacat tcatggagat      540

cactctctta agaataaagc tgagcttgct gattccatga aaaatgaagc agggatcgat      600

gaagggcatg tgataggaga atctgagtca gtgcacagtg gtgcgtctaa gcattcagta      660

gagaaagtca cagagctagc aaaaggtcac ctccttcctg gagtgccagt agaagaccag      720

agcctaccag gagaggccag agccctagaa ggatatgcag atagaggtaa tttcccagca      780

catccagtga atgaagagaa agagactaaa gaagggtctg ttgcagttca gattcctgac      840

ttactggaag acaaagcaca aaagctcagt ttttgtgagg accaaaatgc tcaagataga      900

aattccaaag gttcagatag tttgaataag aaggtagatc tgactctttt gtctccaaaa      960

agtgaaaatg ataaattgaa agaaattagt ctggcttgta aaatcacgga attggaaagc     1020

gtttccttgc caacaccaga aatccagtca gatttcttac atagcaaagt cgaagctcct     1080

ccttcagagg tggcggatac gttagtaata atgactgctt ccaagggtgt tcgactccca     1140

gaacccaaag ataagatttt ggagacacct cagaaaatga cagaaaaatc tgaatcaaag     1200

acaccaggag aagggaaaaa ggaagataaa agcagaatgg cagaaccaat gaaaggctac     1260

atgagaccca ccaagtcccg aggacttact ccacttttgc caaagtctac aatccaggaa     1320

caagagagac ataagcaact gaagtccgct ggaatagcca ggccagaaga aggaaggcct     1380

gtggtgagtg ggacaggaaa tgacatcacc accccaccga acaaggagct cccaccaagc     1440

ccagagaaga aaacaaagcc tttggccacc actcaacctg caaagacttc aacatcgaaa     1500

gccaaaacac agcccacttc tctccctaag cagccagctc ccaccaccat tggtgggttg     1560

aataaaaaac ccatgagcct tgcttcaggc ttagtgccag ctgccccacc caaacgccct     1620

gccgtcgcct ctgccaggcc ttccatctta ccttcaaaag acgtgaagcc aaagcccatt     1680

gcagatgcaa aggctcctga gaagcgggcc tcaccatcca agccagcttc tgccccagcc     1740

tccagatctg ggtccaagag cactcagact gttgcaaaaa ccacaacagc tgctgctgtt     1800

gcctcaactg gcccaagcag taggagcccc tccacgctcc tgcccaagaa gcccactgcc     1860

attaagactg agggaaaacc tgcagaagtc aagaagatga ctgcaaagtc tgtaccagct     1920

gacttgagtc gcccaaagag cacctccacc agttccatga agaaaaccac cactctcagt     1980

gggacagccc ccgctgcagg ggtggttccc agccgagtca aggccacacc catgccctcc     2040

cggccctcca caactccttt catagacaag aagcccacct cggccaaacc cagctccacc     2100

accccccggc tcagccgcct ggccaccaat acttctgctc ctgatctgaa gaatgtccgc     2160

tccaaggttg gctccacgga aaacatcaag catcagcctg gaggaggccg ggccaaagta     2220

gagaaaaaaa cagaggcagc tgctacaacc cgaaagcctg aatctaatgc agtcactaaa     2280

acagccggcc caattgcaag tgcacagaaa caacctgcgg ggaaagtcca gatagtctcc     2340

aaaaaagtga gctacagcca tattcagtcc aagtgtggtt ccaaggacaa tattaagcat     2400

gtccctggag gtggtaatgt tcagattcag aacaagaaag tggacatctc taaggtctcc     2460

tccaagtgtg ggtctaaggc taacatcaag cacaagcctg gtggaggaga tgtcaagatt     2520

gaaagtcaga agttgaactt caaggagaag gcccaggcca aggtgggatc cctcgataat     2580

gtgggccacc tacctgcagg aggtgctgtg aagactgagg gcggtggcag cgaggctcct     2640

ctgtgtccgg gtccccctgc tggggaggag ccggccatct ctgaggcagc gcctgaagct     2700

ggcgccccca cttcagccag tggcctcaat ggccacccca ccctgtcagg gggtggtgac     2760

caaagggagg cccagacctt ggacagccag atccaggaga caagcatcta atgatgacat     2820

tctggtctcg tcttccgtct cccccgtgtt cccctcttgt ctcccctgtt cccctctccc     2880

ttccctcctc ccatgtcact gcagattgag acctacaggc tgacgttccg ggcaaatgcc     2940

agggcccgca ccgaccacgg ggccgacatt gtctcccgcc ccccacactt ccctggcggc     3000

cccaactcgg gctcccgggt ccttggcccc ctttcccggg ctgtccacta gaccagtgag     3060

cgcttgggcg ccgtgctggg cagcccgcta ggctcgcctt ccctcctgct ttgcgtgccc     3120

ggggcagcag cagccctgcc ccacacctcc tctcactccc cagcctgggc ccatctccct     3180

gctttggtct tgccccatca ctgcgccact gctccgtgga ggaggttggg agggggttgg     3240

ggtggttgag gctaagttgg gatctaggag aggagaacca gattctatcc tcatcttttt     3300

ttggttcttt ggtccaaacc caaaagaaac tgacatgccc tcccttctcc ctggatctac     3360

ctggagggaa gagtggaggt ggattccgag tggtgacagg acgctgaccg tggagcttaa     3420

gccactgcct ctccctctgg tcccacaaat gggcgccccc ccctccccat gcaggtggtg     3480

tcgggccctt cttgctgccc tgccccaagt tgggggtcag tgctgcctgt ccccatgctt     3540

aacatacccg cctagctgct gtcacatttt tcttgttttg tccttttatt tttttctaat     3600

aacctaaaaa ctggcaaaat agttctgcag gttgaagcca tgtctacatg aaagtcctca     3660

gtaagtgtta gagggaacag ggcggagata tccttatgcc acccccgctg gaggatgtgg     3720

gcagcttagg gccctggagg cggtgcggca gggaagaggg gtgcagaggc tgtggctggt     3780

gagccggtca ggcacacaag gggcccttgg agcgtggact ggttggtttt gccattttgt     3840

tgtgtgtatg ctgcttttct tttctaacca agaggctggt tttggcatct ctgtcccatt     3900

ccctgggatc tggtggtcag ccctaggata aaaagccagg gctggagaac aagaaagggc     3960

caggagatgg aattccttca ggccggcacc cacaccctag gacatgtaag ccctcatgtc     4020

caagggagcc tcatgcagat agtaggaaat caggtctgga aatttaaaaa taaaaggcat     4080

gagactaagg ctatctgctt cccttatgcc ctgactggag aggggaggga ggagaggcaa     4140

ggcccacaga gggcatccca gctaggcctt gggatggctg cagtgaggag aaatcccggg     4200

aactgtattg acacaaagat tcttattgca cttgtatttt ttgtattaaa gtttgcatgg     4260

tttctaataa aggattcaaa cataagtttg tagtgaaatg gcctgggaga ttccaagggc     4320

ttctctggag ggggattggc tgcagtgtag atttgcctct gaggaggctg ccccagactt     4380

ggcctcctca tgccccctcc tgacctctgc ccttctctgg tcctggcatc cctggagaag     4440

gtaggggtct tgacctaagt ttagatttga tctccatgtg cagggaggct gtcctgggcc     4500

tgacaggtcc tccccctttc tgaggtagca gtgccttgtg gaggtttgac accatgtccc     4560

tagctcccca agcacacacc aggaaactgc aggggctcac ggaggaagtg ctgcctgggc     4620

cagggggacc agctttcctc cgtagagacc atgtgcagaa cacttctgct gtgccaagaa     4680

catgagggag ccagtgtttt gtcagcagga agaaagggcc tgctgggatg aaagtgggaa     4740

ggaaacaggg ttgcgtagtc aggagacacc tcaggggcaa cagcacaggc ccagagtacc     4800

tgctgcctcc actgcgtctg tcctggggtc atgaggatgc tgaggttgac gacaggttcc     4860

aggtcctttc actcctttgg ccaaaggttg ggggtaggtg gcccaagtgg cgtgctctct     4920

aggtagacaa caggagtggt cagagttccc tcaaaggatc ctccactcca gagcacctga     4980

gaaggccggg accagaggcc ctgtgtgatg tgtactccgc agctgtttgg ggtgggacat     5040

ttctgtactt ctcgatttgc ttatggctca gccattacct gtgtcagtcc atgattctgt     5100

tgtaacagtt ttaagagtaa ataaataaag ctgcctgatg tcccatcacg cagaaaaaaa     5160

aaa                                                                   5163


<210>  204
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Glu Thr Thr Gly Asp Gln Gly Ile Glu Gly Met Ala Tyr Met Asp 
1               5                   10                  15      


Glu Asn Arg Asn Ile Thr Phe Thr Cys Pro Arg Thr Pro Ser Glu Leu 
            20                  25                  30          


Ile Asn Lys Ser Ser Pro Leu Glu Val Leu Glu Ser Ala Ala Cys Glu 
        35                  40                  45              


Lys Leu Pro Thr Pro Thr Pro Gln Val Val Lys Glu Gly Asp Ser Phe 
    50                  55                  60                  


Pro Asp Thr Leu Ala Lys Asn Gly Gln Glu Ile Ala Pro Ala Gln Ile 
65                  70                  75                  80  


Ser Lys Ser Leu Met Val Asp Asn Tyr Thr Lys Asp Gly Val Pro Gly 
                85                  90                  95      


Gln Glu Arg Pro Lys Gly Pro Ser Ala Val Val Pro Ser Thr Ser Thr 
            100                 105                 110         


Gly Gly Val Ala Leu Pro Ile Thr Thr Ala Ile Glu Thr Val Asn Ile 
        115                 120                 125             


His Gly Asp His Ser Leu Lys Asn Lys Ala Glu Leu Ala Asp Ser Met 
    130                 135                 140                 


Lys Asn Glu Ala Gly Ile Asp Glu Gly His Val Ile Gly Glu Ser Glu 
145                 150                 155                 160 


Ser Val His Ser Gly Ala Ser Lys His Ser Val Glu Lys Val Thr Glu 
                165                 170                 175     


Leu Ala Lys Gly His Leu Leu Pro Gly Val Pro Val Glu Asp Gln Ser 
            180                 185                 190         


Leu Pro Gly Glu Ala Arg Ala Leu Glu Gly Tyr Ala Asp Arg Gly Asn 
        195                 200                 205             


Phe Pro Ala His Pro Val Asn Glu Glu Lys Glu Thr Lys Glu Gly Ser 
    210                 215                 220                 


Val Ala Val Gln Ile Pro Asp Leu Leu Glu Asp Lys Ala Gln Lys Leu 
225                 230                 235                 240 


Ser Phe Cys Glu Asp Gln Asn Ala Gln Asp Arg Asn Ser Lys Gly Ser 
                245                 250                 255     


Asp Ser Leu Asn Lys Lys Val Asp Leu Thr Leu Leu Ser Pro Lys Ser 
            260                 265                 270         


Glu Asn Asp Lys Leu Lys Glu Ile Ser Leu Ala Cys Lys Ile Thr Glu 
        275                 280                 285             


Leu Glu Ser Val Ser Leu Pro Thr Pro Glu Ile Gln Ser Asp Phe Leu 
    290                 295                 300                 


His Ser Lys Val Glu Ala Pro Pro Ser Glu Val Ala Asp Thr Leu Val 
305                 310                 315                 320 


Ile Met Thr Ala Ser Lys Gly Val Arg Leu Pro Glu Pro Lys Asp Lys 
                325                 330                 335     


Ile Leu Glu Thr Pro Gln Lys Met Thr Glu Lys Ser Glu Ser Lys Thr 
            340                 345                 350         


Pro Gly Glu Gly Lys Lys Glu Asp Lys Ser Arg Met Ala Glu Pro Met 
        355                 360                 365             


Lys Gly Tyr Met Arg Pro Thr Lys Ser Arg Gly Leu Thr Pro Leu Leu 
    370                 375                 380                 


Pro Lys Ser Thr Ile Gln Glu Gln Glu Arg His Lys Gln Leu Lys Ser 
385                 390                 395                 400 


Ala Gly Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr 
                405                 410                 415     


Gly Asn Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro 
            420                 425                 430         


Glu Lys Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser 
        435                 440                 445             


Thr Ser Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala 
    450                 455                 460                 


Pro Thr Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser 
465                 470                 475                 480 


Gly Leu Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala 
                485                 490                 495     


Arg Pro Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala 
            500                 505                 510         


Asp Ala Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser 
        515                 520                 525             


Ala Pro Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys 
    530                 535                 540                 


Thr Thr Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser 
545                 550                 555                 560 


Pro Ser Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly 
                565                 570                 575     


Lys Pro Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp 
            580                 585                 590         


Leu Ser Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr 
        595                 600                 605             


Thr Leu Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val 
    610                 615                 620                 


Lys Ala Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp 
625                 630                 635                 640 


Lys Lys Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser 
                645                 650                 655     


Arg Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser 
            660                 665                 670         


Lys Val Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg 
        675                 680                 685             


Ala Lys Val Glu Lys Lys Thr Glu Ala Ala Ala Thr Thr Arg Lys Pro 
    690                 695                 700                 


Glu Ser Asn Ala Val Thr Lys Thr Ala Gly Pro Ile Ala Ser Ala Gln 
705                 710                 715                 720 


Lys Gln Pro Ala Gly Lys Val Gln Ile Val Ser Lys Lys Val Ser Tyr 
                725                 730                 735     


Ser His Ile Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
            740                 745                 750         


Pro Gly Gly Gly Asn Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser 
        755                 760                 765             


Lys Val Ser Ser Lys Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro 
    770                 775                 780                 


Gly Gly Gly Asp Val Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu 
785                 790                 795                 800 


Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Val Gly His Leu Pro 
                805                 810                 815     


Ala Gly Gly Ala Val Lys Thr Glu Gly Gly Gly Ser Glu Ala Pro Leu 
            820                 825                 830         


Cys Pro Gly Pro Pro Ala Gly Glu Glu Pro Ala Ile Ser Glu Ala Ala 
        835                 840                 845             


Pro Glu Ala Gly Ala Pro Thr Ser Ala Ser Gly Leu Asn Gly His Pro 
    850                 855                 860                 


Thr Leu Ser Gly Gly Gly Asp Gln Arg Glu Ala Gln Thr Leu Asp Ser 
865                 870                 875                 880 


Gln Ile Gln Glu Thr Ser Ile 
                885         


<210>  205
<211>  3224
<212>  DNA
<213>  Homo sapiens

<400>  205
aggccccacc cgctggtggc ccggtccgcg tgtgcgccga ctctcgcact ctcctcgctc       60

cgggcgccca gactctgaga gagagcgacg gccatcatag aacagcgaag gcagtcgatc      120

ggcctgcggt ccgcttcggc attcgcaggc cgcaggcggg aggctagagc ccccaggcgc      180

acctcgcccc aaccgcccgc ggctcgggca gctctgcaga gacgtcgtgg cggcagggcc      240

agcacccatt ggtccgccac agccctccgc cctccccctc gccacgctta ttggccggag      300

cggcggcgct cgccgggtag gcggtggcgg cgtccctccc ttgcgccggc cctcaagagg      360

cgacgaggaa gcggccgcct ccctgcgccc cgcccctccg gctagctcgc tggctcccgg      420

ctcctcccga cgtctcctac ctcctcacgg ctcttcccgg cgctctcctg gctcccttct      480

gccccagctc cgtctcggcg gcggcgggca gttgcagtgg tgcagaatgg ctgacctcag      540

tcttgcagat gcattaacag aaccatctcc agacattgag ggagagataa agcgggactt      600

cattgccaca ctagaggcag aggcctttga tgatgttgtg ggagaaactg ttggaaaaac      660

agactatatt cctctcctgg atgttgatga gaaaaccggg aactcagagt caaagaagaa      720

accgtgctca gaaactagcc agattgaaga tactccatct tctaaaccaa cactcctagc      780

caatggtggt catggagtag aagggagcga tactacagaa gcctagcgtg tctctcaaca      840

ctggggctgc tgcaacacca gaccagtgat ctttcctaag catcgttata cttctaaaac      900

cttcagcatt ttgcagagct ttgcttttca ttcctggaca tgatgtagaa gaaactgagg      960

gtagttcttc ggggcctatt tctgctgatg cctgagcaaa caacctgctt cctcttgtgc     1020

tctgcagggt ttgatggagc ctcatttccc tttgtgaaca caaagtgcaa aatgaattct     1080

ttttaatttt agtaattttt acaaaggtta tctaatgtct tttatttctt gttttcttta     1140

tgattttatc atttgattca ttctcacatt tttttccttt aaatattttt agttgacctt     1200

tttcctttgg ttttcaaatg ttcaacatga atcagaatag tgtaacacca aatgagaaca     1260

tgtgttttca taaaggggtt gaggccacca gtactgcagc gaatttcctt ttcttctccc     1320

tcctccttcc ttctctgagc ttgcttttag ggaaggttaa tcttacaggc tacctatgtt     1380

tctctccacc ttactaaaat ctaaataatg atagatattt taagttttta aattgagtag     1440

ttctgagtaa tcctagaata tttttccaaa ttaaataatc ctttattatt tgcaagttgg     1500

gccaaatttt tttttttttg gagacggact cttaacaatc taagattgtt tcaacaggac     1560

tttcttattc ccattcctaa ttttttcaaa ctaattgctt aaatctagaa ccagttgaga     1620

ttagtactgt acaatggtat gctttgattg tatttataga aatataacat aaaacatgga     1680

ccatgttttg aaatcttaga ggaattctgg tttaaaatct gaaatacttt aaagttttct     1740

atccttttac tgattatgca gcttcttata acccccaagg tacagattat ttcagcttaa     1800

aagaaataat tggcaccatg ttctgagaaa gattttgaga tatacattgt tttttgtttt     1860

tgagacaggg tctcactctt gcctaggctg gagtgcggtg gcgcgatctt ggcttactgc     1920

accctctgcc tcccaggttc aagtggttct cctgcctcag cctcccaagt agctgggatt     1980

ataggtgtgc gccaccacac cagctaattt ttgtattttt agtagagacg gggttttact     2040

ttgttggcca ggctggtctc gaactcctga tctcaagtga tccacccgcc ttggccaccc     2100

aaagtgctgg gattacaggt gtgagacact gtgcctggcc agatatacat tgttttagat     2160

cccctgatac agaactactt ttgagatggt aagattagaa tatcatgaaa gtttaaactg     2220

aatccttgca gcgacttccg gaatttagga agcattccct cttctacagg ggtctggtca     2280

caagggctgg attctctgac aaaaatttct tctatggatt ctggacagaa gacacttgag     2340

ggtgatatgt tttaaaggaa agaggttatg cttatcttct tagcagttga taaaatatta     2400

aaactctctt gccatagaga atacaccatc aaagaaaaca caaccctttc cctttggtgt     2460

acagttattt attaagttga ttttggggtt tctttcgcca gggatctttt caaaactggt     2520

agtagttatt tttaaaaatc atgtttgaca tctttctatt gctcgtaacc agtccctgta     2580

gctgtctaag ttatgggtgg agaagcctgg gtatgacttt ccgttgtgta cactcacact     2640

tcatgattga catttattta ttcttttatt tccatttggt tatgcttatt tttgtttgaa     2700

atttgttttt ttcaaatatg tttccttttt gaacttacag aattgttgaa attttctact     2760

aacagccagc taaaatttgg tatatgttag ctctatctgt ttcacttgga cgtttcattt     2820

tgaaagaaag aaattttatg tttcacatat agttttatac aaagtagcca gtcccataat     2880

gaaatgctgt attgccatag tggtcacacc caagtggtcc agtatctcaa tggtgaggca     2940

gccagactgg tcagggctgc tttgttgaaa tgtgatgatt ttcatatgcc ttctttctct     3000

ttctctctct cttttttttt ccttttttgg cccaatgttg aagatgtaga actttgtttt     3060

taaataatgt ttttataatt tcattcgtat acctaagttt gtattttttg tgactttgga     3120

cttcaacagt ttgtatattg ggacttctaa tgtgattact gtactaaata aattccacta     3180

ataaacatct tacattaaca ccttaaaaaa aaaaaaaaaa aaaa                      3224


<210>  206
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr Glu Pro Ser Pro Asp 
1               5                   10                  15      


Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala Thr Leu Glu Ala Glu 
            20                  25                  30          


Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly Lys Thr Asp Tyr Ile 
        35                  40                  45              


Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn Ser Glu Ser Lys Lys 
    50                  55                  60                  


Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp Thr Pro Ser Ser Lys 
65                  70                  75                  80  


Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val Glu Gly Ser Asp Thr 
                85                  90                  95      


Thr Glu Ala 
            


<210>  207
<211>  4987
<212>  DNA
<213>  Homo sapiens

<400>  207
ggggcagcag gtgctggcca ccacattgtc cagcaaggtg gcagcagagg cctcctaggt       60

ccccttccta ggaaaggagc ctgggctgcc ctgatgagtc tcctgtctct ctctctcccg      120

caggatgaag atgagacgct acaagctctt tctcatgttc tgtatggccg gcctgtgcct      180

catctccttc ctgcacttct tcaagaccct gtcctatgtc accttccccc gagaactggc      240

ctccctcagc cctaacctgg tgtccagctt tttctggaac aatgccccgg tcacgcccca      300

ggccagcccc gagccaggag gccctgacct gctgcgtacc ccactctact cccactcgcc      360

cctgctgcag ccgctgccgc ccagcaaggc ggccgaggag ctccaccggg tggacttggt      420

gctgcccgag gacaccaccg agtatttcgt gcgcaccaag gccggcggcg tctgcttcaa      480

acccggcacc aagatgctgg agaggccgcc cccgggacgg ccggaggaga agcctgaggg      540

ggccaacggc tcctcggccc ggcggccacc ccggtacctc ctgagcgccc gggagcgcac      600

ggggggccga ggcgcccggc gcaagtgggt ggagtgcgtg tgcctgcccg gctggcacgg      660

acccagctgc ggcgtgccca ctgtggtgca gtactccaac ctgcccacca aggagcggct      720

ggtgcccagg gaggtgccgc gccgcgtcat caacgccatc aacgtcaacc acgagttcga      780

cctgctggac gtgcgcttcc acgagctggg cgacgtggtg gacgcctttg tggtgtgcga      840

gtccaacttc acggcttatg gggagccgcg gccgctcaag ttccgggaga tgctgaccaa      900

tggcaccttc gagtacatcc gccacaaggt gctctatgtc ttcctggacc acttcccgcc      960

cggcggccgg caggacggct ggatcgccga cgactacctg cgcaccttcc tcacccagga     1020

cggcgtctcg cggctgcgca acctgcggcc cgacgacgtc ttcatcattg acgatgcgga     1080

cgagatcccg gcccgtgacg gcgtcctttt cctcaagctc tacgatggct ggaccgagcc     1140

cttcgccttc cacatgcgca agtcgctcta cggcttcttc tggaagcagc cgggcaccct     1200

ggaggtggtg tcaggctgca cggtggacat gctgcaggca gtgtatgggc tggacggcat     1260

ccgcctgcgc cgccgccagt actacaccat gcccaacttc agacagtatg agaaccgcac     1320

cggccacatc ctggtgcagt ggtcgctggg cagccccctg cacttcgccg gctggcactg     1380

ctcctggtgc ttcacgcccg agggcatcta cttcaagctc gtgtccgccc agaatggcga     1440

cttcccacgc tggggtgact acgaggacaa gcgggacctg aactacatcc gcggcctgat     1500

ccgcaccggg ggctggttcg acggcacgca gcaggagtac ccgcctgcag accccagcga     1560

gcacatgtat gcgcccaagt acctgctgaa gaactacgac cggttccact acctgctgga     1620

caacccctac caggagccca ggagcacggc ggcgggcggg tggcgccaca ggggtcccga     1680

gggaaggccg cccgcccggg gcaaactgga cgaggcggaa gtctagagct gcatgatctg     1740

atagggtttg tgacagggcg ggggtggcgg cggcccctag cgctatctcc ctgcctcctg     1800

ccggctcctt ggttcttgag gggaccagga gtgggtgggg agtgggggtg ggggtagggt     1860

ttccctactg aagcccttgt gaatcaaggg tcaggccttt gagctcagaa aatatccctc     1920

ctgttgggag agggcgcagg ccgtgacgtc tgggtggccc ttatgactgc caagactgct     1980

gtggccagga ggtgccactg gagtgtgcgt ggtggtccct gggtagcggg ggagggtagg     2040

caggattggg gaagagagcc tgcaggatct caccaggcag cctctggggg gtggccaggc     2100

cgggaaaaag cccaccattt ggcatccctg ggccttgggc tccgtgtggg agaccggcct     2160

gccaggagga cccagggctc tgtaagtaga tgcatttggg tccaggagga agcgtggaca     2220

cctcgtaggg aagagatgaa aaagccacat cctaccaaga ggaggtgctg agggatgctt     2280

tgcagtgtag tcagaagtgc tgggccagat ggagacagaa ctccaccccc tgccgcaaag     2340

gacaggacct ggctgccctg ggatgctggt gcctgagtct gtctctgtgc acccctcagg     2400

ctgtcgtgag ccaacacagg ggcctggaga accctgagga gctttccttt tggttctaaa     2460

cccggcgttg acgttccttc tccctttcac attgctgtct tgtggactgt gcactcagtc     2520

cttgcaaggc caagagtcca gttgtaggtg tggccttgag ggggaagtgg ggaggagaag     2580

actgacatga gtcctctgca cggatccgtc tctccctccc catcacccct tccttctgac     2640

acccagtccc agctgtccac tgtcccaggt gcagtcactg ttgtgccctt ccttggggca     2700

ggctggctgg gggccagaaa ggggccatga ggctgtcttg ggcccaaaaa gggacaataa     2760

ggccagttgt atgcttcctg ttcctcatag cttgccttgg tggggatgtc tttgttggag     2820

ttgattctga gctgctgtga ttaggagacc ctgaaataca gtggtttaag caagatggaa     2880

gcttgtttct aattagtcta gattgagatg gcccagagct ggtagggcag ctctgcgttt     2940

cttcatacgc accttccaat tctgggtaca cagcggctgc tccagcgccc accctcctgt     3000

gtgcatccaa gcctggggga agcagaaata gacaagaggg cacacccact ttttgctaaa     3060

ggcatgagcc agaattggca ggctcacctc tgctggcctc tcattggctg ggactcagtc     3120

acatggccac aagcagctgc tagggaacct gggaagtgta gtcttcagcg gggccgccat     3180

gtgcctggcc tcaccttggg agttatctta ttgatggagg agaagagaat ggatatgggg     3240

gaccagtagc atctctggga gagggggagg gagcagcaat aactcagtcg tcggatccag     3300

ctctcattgt cagagtttcc ggaacagctt gctcctgttt ccctcactgt gcagcccagg     3360

gctgggggca gtgaggagct tgcagctctg tgggaagggg aaacaccccc tcccctcggc     3420

ccctcagacg ctacccaatg atgccggttt gcagagttgg cctgtggaat ggctcatgtt     3480

tgtgcgtgtg tgtgtgtata tttatgggca tgggtgcatg cttggtgtgt atttgtacat     3540

gtctgtattg ctgtgtccct gtaaatacat gcttgtgtat ggatggaaga ggccaggccc     3600

aggcctggcc tcttcctcgg gcctgtggcc acacctcctg cagctcccca aaatgactga     3660

ggcagaaagc ccttggggag cctagaaagc aaagctaaag gggatgcagg gtctgtctgt     3720

ctgtctgtct ttcagtctga ggaatgagaa tcctgacctg agggctgtgc agctgagagc     3780

ccactacctc cccagcccct ctcggcccca gccgcatcat cccacctgtc ccctcccccc     3840

cacctccagt ggggctttct ccagatgtct tatggttggg ggtttcctga tgggccagga     3900

gaggagggca tcttcttgcg acagcactgt ctgggttaag tgcccagtga gggcatggtg     3960

tggggagctg gcctcagagg agccgctggt gggcaagcgt gaagtgggct gaggggctct     4020

gagccacttt gctcccatct aggggactgc cccccatgga actcctttga agtcacagca     4080

gccttccttt ctgtttgctc ttggggctga gaggtggctc aaacactcgg ggtccctatg     4140

gctctgggtc aatctaggcc aggctgcacc ccatggacag ggagtctcag ggctcctgat     4200

catgcccagg ccctggcctg gggcctccct ccttggcagc tttcccaccc ccacgcccct     4260

ggcatcctca gttgctatgg gatgcccctc cagggcacca gctcagggct aagcgaagga     4320

agataggagc agctcagagc tgccaggctc tgccttcctc acagacctgg tggggcaggt     4380

cctgttcaca gcagcaggag tgaaggcctg gccatcggtg gagagggcag ctgtcagagg     4440

gctgggggcc agggcacagg attgaagagt ttcacatatc atcacagcat acactgggaa     4500

tttggtgggg gcagaagaac ccagggccac tccctcaata tgaagggaaa ccaagctgaa     4560

tgtgaccacc ggcacactgc tgccatgtcc catgtccacc tttctccccg ggaataactg     4620

gccctgagac ccctagaccc aaggaggcct gtccatgcca agcatccggg aagcatggct     4680

ggccttatcc acccatgggt cacgtcggtt cccaggggca gcatgggaga tctttggggg     4740

caacagggag agtctgggtg gggagacggg acttgtccaa gcagaaggca ggaccctggg     4800

aaatgcataa tgtaaggaca tcaataatag tattattttt tttgtaaggg aaaatcaata     4860

tgtacattct gaaatcattt tctctgtaaa tggttggatt tcatttcacc cttaaaggga     4920

tgcttaaagg agaagataat attaataata aaaacagcta caaagtctga aaaaaaaaaa     4980

aaaaaaa                                                               4987


<210>  208
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly Arg Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly 
                165                 170                 175     


Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn 
            180                 185                 190         


Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val 
        195                 200                 205             


Ile Asn Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg 
    210                 215                 220                 


Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser 
225                 230                 235                 240 


Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met 
                245                 250                 255     


Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val 
            260                 265                 270         


Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala 
        275                 280                 285             


Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu 
    290                 295                 300                 


Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu 
305                 310                 315                 320 


Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp 
                325                 330                 335     


Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly Phe Phe 
            340                 345                 350         


Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp 
        355                 360                 365             


Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg 
    370                 375                 380                 


Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly 
385                 390                 395                 400 


His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly 
                405                 410                 415     


Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu 
            420                 425                 430         


Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp 
        435                 440                 445             


Lys Arg Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp 
    450                 455                 460                 


Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His 
465                 470                 475                 480 


Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr 
                485                 490                 495     


Leu Leu Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly 
            500                 505                 510         


Trp Arg His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu 
        515                 520                 525             


Asp Glu Ala Glu Val 
    530             


<210>  209
<211>  5102
<212>  DNA
<213>  Homo sapiens

<400>  209
gagcggccgc gccgggtccc cgggacgggg tggaagtggg ggtgggggga ggggatcggg       60

gccgggccgg ggccgcgctg cctgcgatgc cgggcgcccg ccgcagccgc tgccgccgga      120

gcccgggatg gggcgagagg ctgcggcgga cgccagcatc tccccgccgg ggaccccggg      180

ggccgcggag ccgccgccgc cgctgctgcc gccgttgctg agacccagcg ggcgatggga      240

tgaagatgag acgctacaag ctctttctca tgttctgtat ggccggcctg tgcctcatct      300

ccttcctgca cttcttcaag accctgtcct atgtcacctt cccccgagaa ctggcctccc      360

tcagccctaa cctggtgtcc agctttttct ggaacaatgc cccggtcacg ccccaggcca      420

gccccgagcc aggaggccct gacctgctgc gtaccccact ctactcccac tcgcccctgc      480

tgcagccgct gccgcccagc aaggcggccg aggagctcca ccgggtggac ttggtgctgc      540

ccgaggacac caccgagtat ttcgtgcgca ccaaggccgg cggcgtctgc ttcaaacccg      600

gcaccaagat gctggagagg ccgcccccgg gacggccgga ggagaagcct gagggggcca      660

acggctcctc ggcccggcgg ccaccccggt acctcctgag cgcccgggag cgcacggggg      720

gccgaggcgc ccggcgcaag tgggtggagt gcgtgtgcct gcccggctgg cacggaccca      780

gctgcggcgt gcccactgtg gtgcagtact ccaacctgcc caccaaggag cggctggtgc      840

ccagggaggt gccgcgccgc gtcatcaacg ccatcaacgt caaccacgag ttcgacctgc      900

tggacgtgcg cttccacgag ctgggcgacg tggtggacgc ctttgtggtg tgcgagtcca      960

acttcacggc ttatggggag ccgcggccgc tcaagttccg ggagatgctg accaatggca     1020

ccttcgagta catccgccac aaggtgctct atgtcttcct ggaccacttc ccgcccggcg     1080

gccggcagga cggctggatc gccgacgact acctgcgcac cttcctcacc caggacggcg     1140

tctcgcggct gcgcaacctg cggcccgacg acgtcttcat cattgacgat gcggacgaga     1200

tcccggcccg tgacggcgtc cttttcctca agctctacga tggctggacc gagcccttcg     1260

ccttccacat gcgcaagtcg ctctacggct tcttctggaa gcagccgggc accctggagg     1320

tggtgtcagg ctgcacggtg gacatgctgc aggcagtgta tgggctggac ggcatccgcc     1380

tgcgccgccg ccagtactac accatgccca acttcagaca gtatgagaac cgcaccggcc     1440

acatcctggt gcagtggtcg ctgggcagcc ccctgcactt cgccggctgg cactgctcct     1500

ggtgcttcac gcccgagggc atctacttca agctcgtgtc cgcccagaat ggcgacttcc     1560

cacgctgggg tgactacgag gacaagcggg acctgaacta catccgcggc ctgatccgca     1620

ccgggggctg gttcgacggc acgcagcagg agtacccgcc tgcagacccc agcgagcaca     1680

tgtatgcgcc caagtacctg ctgaagaact acgaccggtt ccactacctg ctggacaacc     1740

cctaccagga gcccaggagc acggcggcgg gcgggtggcg ccacaggggt cccgagggaa     1800

ggccgcccgc ccggggcaaa ctggacgagg cggaagtcta gagctgcatg atctgatagg     1860

gtttgtgaca gggcgggggt ggcggcggcc cctagcgcta tctccctgcc tcctgccggc     1920

tccttggttc ttgaggggac caggagtggg tggggagtgg gggtgggggt agggtttccc     1980

tactgaagcc cttgtgaatc aagggtcagg cctttgagct cagaaaatat ccctcctgtt     2040

gggagagggc gcaggccgtg acgtctgggt ggcccttatg actgccaaga ctgctgtggc     2100

caggaggtgc cactggagtg tgcgtggtgg tccctgggta gcgggggagg gtaggcagga     2160

ttggggaaga gagcctgcag gatctcacca ggcagcctct ggggggtggc caggccggga     2220

aaaagcccac catttggcat ccctgggcct tgggctccgt gtgggagacc ggcctgccag     2280

gaggacccag ggctctgtaa gtagatgcat ttgggtccag gaggaagcgt ggacacctcg     2340

tagggaagag atgaaaaagc cacatcctac caagaggagg tgctgaggga tgctttgcag     2400

tgtagtcaga agtgctgggc cagatggaga cagaactcca ccccctgccg caaaggacag     2460

gacctggctg ccctgggatg ctggtgcctg agtctgtctc tgtgcacccc tcaggctgtc     2520

gtgagccaac acaggggcct ggagaaccct gaggagcttt ccttttggtt ctaaacccgg     2580

cgttgacgtt ccttctccct ttcacattgc tgtcttgtgg actgtgcact cagtccttgc     2640

aaggccaaga gtccagttgt aggtgtggcc ttgaggggga agtggggagg agaagactga     2700

catgagtcct ctgcacggat ccgtctctcc ctccccatca ccccttcctt ctgacaccca     2760

gtcccagctg tccactgtcc caggtgcagt cactgttgtg cccttccttg gggcaggctg     2820

gctgggggcc agaaaggggc catgaggctg tcttgggccc aaaaagggac aataaggcca     2880

gttgtatgct tcctgttcct catagcttgc cttggtgggg atgtctttgt tggagttgat     2940

tctgagctgc tgtgattagg agaccctgaa atacagtggt ttaagcaaga tggaagcttg     3000

tttctaatta gtctagattg agatggccca gagctggtag ggcagctctg cgtttcttca     3060

tacgcacctt ccaattctgg gtacacagcg gctgctccag cgcccaccct cctgtgtgca     3120

tccaagcctg ggggaagcag aaatagacaa gagggcacac ccactttttg ctaaaggcat     3180

gagccagaat tggcaggctc acctctgctg gcctctcatt ggctgggact cagtcacatg     3240

gccacaagca gctgctaggg aacctgggaa gtgtagtctt cagcggggcc gccatgtgcc     3300

tggcctcacc ttgggagtta tcttattgat ggaggagaag agaatggata tgggggacca     3360

gtagcatctc tgggagaggg ggagggagca gcaataactc agtcgtcgga tccagctctc     3420

attgtcagag tttccggaac agcttgctcc tgtttccctc actgtgcagc ccagggctgg     3480

gggcagtgag gagcttgcag ctctgtggga aggggaaaca ccccctcccc tcggcccctc     3540

agacgctacc caatgatgcc ggtttgcaga gttggcctgt ggaatggctc atgtttgtgc     3600

gtgtgtgtgt gtatatttat gggcatgggt gcatgcttgg tgtgtatttg tacatgtctg     3660

tattgctgtg tccctgtaaa tacatgcttg tgtatggatg gaagaggcca ggcccaggcc     3720

tggcctcttc ctcgggcctg tggccacacc tcctgcagct ccccaaaatg actgaggcag     3780

aaagcccttg gggagcctag aaagcaaagc taaaggggat gcagggtctg tctgtctgtc     3840

tgtctttcag tctgaggaat gagaatcctg acctgagggc tgtgcagctg agagcccact     3900

acctccccag cccctctcgg ccccagccgc atcatcccac ctgtcccctc ccccccacct     3960

ccagtggggc tttctccaga tgtcttatgg ttgggggttt cctgatgggc caggagagga     4020

gggcatcttc ttgcgacagc actgtctggg ttaagtgccc agtgagggca tggtgtgggg     4080

agctggcctc agaggagccg ctggtgggca agcgtgaagt gggctgaggg gctctgagcc     4140

actttgctcc catctagggg actgcccccc atggaactcc tttgaagtca cagcagcctt     4200

cctttctgtt tgctcttggg gctgagaggt ggctcaaaca ctcggggtcc ctatggctct     4260

gggtcaatct aggccaggct gcaccccatg gacagggagt ctcagggctc ctgatcatgc     4320

ccaggccctg gcctggggcc tccctccttg gcagctttcc cacccccacg cccctggcat     4380

cctcagttgc tatgggatgc ccctccaggg caccagctca gggctaagcg aaggaagata     4440

ggagcagctc agagctgcca ggctctgcct tcctcacaga cctggtgggg caggtcctgt     4500

tcacagcagc aggagtgaag gcctggccat cggtggagag ggcagctgtc agagggctgg     4560

gggccagggc acaggattga agagtttcac atatcatcac agcatacact gggaatttgg     4620

tgggggcaga agaacccagg gccactccct caatatgaag ggaaaccaag ctgaatgtga     4680

ccaccggcac actgctgcca tgtcccatgt ccacctttct ccccgggaat aactggccct     4740

gagaccccta gacccaagga ggcctgtcca tgccaagcat ccgggaagca tggctggcct     4800

tatccaccca tgggtcacgt cggttcccag gggcagcatg ggagatcttt gggggcaaca     4860

gggagagtct gggtggggag acgggacttg tccaagcaga aggcaggacc ctgggaaatg     4920

cataatgtaa ggacatcaat aatagtatta ttttttttgt aagggaaaat caatatgtac     4980

attctgaaat cattttctct gtaaatggtt ggatttcatt tcacccttaa agggatgctt     5040

aaaggagaag ataatattaa taataaaaac agctacaaag tctgaaaaaa aaaaaaaaaa     5100

aa                                                                    5102


<210>  210
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly Arg Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly 
                165                 170                 175     


Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn 
            180                 185                 190         


Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val 
        195                 200                 205             


Ile Asn Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg 
    210                 215                 220                 


Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser 
225                 230                 235                 240 


Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met 
                245                 250                 255     


Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val 
            260                 265                 270         


Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala 
        275                 280                 285             


Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu 
    290                 295                 300                 


Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu 
305                 310                 315                 320 


Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp 
                325                 330                 335     


Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly Phe Phe 
            340                 345                 350         


Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp 
        355                 360                 365             


Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg 
    370                 375                 380                 


Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly 
385                 390                 395                 400 


His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly 
                405                 410                 415     


Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu 
            420                 425                 430         


Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp 
        435                 440                 445             


Lys Arg Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp 
    450                 455                 460                 


Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His 
465                 470                 475                 480 


Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr 
                485                 490                 495     


Leu Leu Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly 
            500                 505                 510         


Trp Arg His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu 
        515                 520                 525             


Asp Glu Ala Glu Val 
    530             


<210>  211
<211>  3044
<212>  DNA
<213>  Homo sapiens

<400>  211
aagtttggta gagtgtgttg tggggacagc agtatggtgt gagggaagga gagagttcag       60

tctattataa tcattagtct attgacttgt ggtaattgag ctataggaga taaattccta      120

cttactctac acatttaatg gactcttcct cccaccccat cttccctgtc cctttctttt      180

tccacagcag ctctgcaacg ggccaatagc ttccagtctc caaccccaag caaataccag      240

aactggagga gagaattctg gtggagtttg acgccagtga acaaaagaac tatgtcacct      300

cctaaggacc cttctccttc tcttcctctt ccttcatcgt cttcccattc atcttcccca      360

ccatcttctt cttcaaccag tgtttctggg aatgctccag atggttcctc cccgcctcag      420

atgacagctt ctgagcccct ctcgcaagtc tcgagaggtc atccaagtcc tcccacccca      480

aactttcgga ggcgagccgt agcccaagga gcacccaggg aaattcccct gtatctgcct      540

catcacccaa agccagagtg ggcagagtac tgcctggtga gccctggtga agatggcctc      600

tcagaccctg cagagatgac ttctgatgag tgccagccag cagaggcccc tcttggggac      660

atcggaagca accacagaga cccacacccc atctggggga aggacaggag ctggacaggg      720

caagagctat ctcccttggc tggagaagac cgggaaaaag ggagtactgg agccaggaag      780

gaagaagagg gagggccagt gctggtaaag gagaagttgg gcctgaagaa gttagtcctc      840

actcaggagc agaagaccat gttgttggat tggaatgact ccatccctga gagtgtgcac      900

ctcaaagctg gggagcgaat ttcccagaaa agtgctgaga atggtagagg aggccgtgtg      960

ctaaaaccag tccgccccct gctgctccct agggcagcag gagagcccct gccaacccag     1020

agaggggccc aggagaagat ggggacccct gcggaacaag ctcaagggga gcgaaacgtg     1080

cctccaccca agtccccact gcggctcata gccaatgcca tccgaaggtc tctagagccc     1140

ctcctttcca actctgaagg cgggaagaag gcctgggcca agcaagaatc caaaactttg     1200

cccgcacagg cctgcactcg ctcattcagc cttcggaaaa ccaattccaa taaagacggg     1260

gaccagcatt cccctgggag aaaccagtcc tcagccttta gccctcctga ccctgccctc     1320

cgcacccaca gtttgcccaa tcggccatcc aaggtctttc ctgcacttag gtccccaccc     1380

tgcagcaaga ttgaagatgt ccccacactc ctcgagaaag tgagtttgca agagaacttc     1440

ccagatgctt ctaagcctcc aaagaaaaga atctcacttt tttcctccct cagactcaaa     1500

gacaaatctt ttgagagttt cctccaagaa tccagacaaa gaaaggacat cagggacctc     1560

tttggcagcc ccaagaggaa ggtgctgcct gaagatagtg cgcaggccct ggagaagctg     1620

ctgcagcctt tcaaaagcac ctccctgcgc caggcagctc ctcctcctcc tcctcctcct     1680

cctcctcctc ctcctcctcc tacagcggga ggtgcagact ccaagaactt tcccctcaga     1740

gcacaggtaa cagaggcttc ctcttctgcc tcttcaacct cctcctcctc tgcagatgaa     1800

gaatttgatc cccagctttc cttgcagtta aaggagaaga agacacttag aagaagaaag     1860

aagctagaaa aagcaatgaa gcagttggtt aagcaagaag aattgaaaag actctataag     1920

gctcaggcca tccagaggca gctggaggag gtggaggagc ggcagagggc ttctgagatc     1980

cagggtgtga ggctggagaa ggcgttgcga ggagaagcag attcaggcac acaggatgaa     2040

gcacagcttt tgcaggaatg gtttaagctg gttctggaga agaataaatt aatgcgatat     2100

gagtcggagc tcctaatcat ggcccaggaa ctggaattag aagatcatca aagcagactg     2160

gagcagaaac tgagagagaa aatgctcaag gaggagagcc agaaagatga gaaggatcta     2220

aacgaagagc aagaagtatt caccgagctg atgcaagtga ttgagcaaag ggacaaactc     2280

gtcgattcct tagaggaaca acgcatcaga gaaaaagccg aggaccagca ctttgaaagc     2340

ttcgtattct ccagaggctg tcagctgagc aggacttgag gaggcccgta gtccctctcc     2400

ctggctgcac gttgggaccg gatcaggcca agtgcaccac acaccctcat gggtctttct     2460

gcaggattta tcatccctgg aacttgttat accttactgc attttttaaa attaaaattc     2520

tcttgcacgc atggcagctt cccaaggttc ttccagagat tcaaatgaag aaaacccaaa     2580

gactctttgg caattggcag tcaacttcag ccaggctctc agactggagg tgttgttggc     2640

agatgaccag cattgttttc cctagaaagt gacacaaaga cttgactttc ctgctacttt     2700

tatcattttc cttcccaatt cattgagtta catactttaa gatttttgag aagctgcctt     2760

ttcattaata tatccatatt tgcctttttt gtatggatga ccagtttcca aatgtcagaa     2820

agaagcagcc gcagtttaaa gattaggtta atatttaaat tgtgtttcca gagaaagagg     2880

agaaaccttg agattactga ttacataaag caaataactc atatagcagg tgttaattca     2940

atccagggtg aatttaattt accaggtgca tttataagcc ttaatataat atacataagc     3000

aatgagagct taatagaaca tttgagcctt aattttattt taag                      3044


<210>  212
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ser Pro Pro Lys Asp Pro Ser Pro Ser Leu Pro Leu Pro Ser Ser 
1               5                   10                  15      


Ser Ser His Ser Ser Ser Pro Pro Ser Ser Ser Ser Thr Ser Val Ser 
            20                  25                  30          


Gly Asn Ala Pro Asp Gly Ser Ser Pro Pro Gln Met Thr Ala Ser Glu 
        35                  40                  45              


Pro Leu Ser Gln Val Ser Arg Gly His Pro Ser Pro Pro Thr Pro Asn 
    50                  55                  60                  


Phe Arg Arg Arg Ala Val Ala Gln Gly Ala Pro Arg Glu Ile Pro Leu 
65                  70                  75                  80  


Tyr Leu Pro His His Pro Lys Pro Glu Trp Ala Glu Tyr Cys Leu Val 
                85                  90                  95      


Ser Pro Gly Glu Asp Gly Leu Ser Asp Pro Ala Glu Met Thr Ser Asp 
            100                 105                 110         


Glu Cys Gln Pro Ala Glu Ala Pro Leu Gly Asp Ile Gly Ser Asn His 
        115                 120                 125             


Arg Asp Pro His Pro Ile Trp Gly Lys Asp Arg Ser Trp Thr Gly Gln 
    130                 135                 140                 


Glu Leu Ser Pro Leu Ala Gly Glu Asp Arg Glu Lys Gly Ser Thr Gly 
145                 150                 155                 160 


Ala Arg Lys Glu Glu Glu Gly Gly Pro Val Leu Val Lys Glu Lys Leu 
                165                 170                 175     


Gly Leu Lys Lys Leu Val Leu Thr Gln Glu Gln Lys Thr Met Leu Leu 
            180                 185                 190         


Asp Trp Asn Asp Ser Ile Pro Glu Ser Val His Leu Lys Ala Gly Glu 
        195                 200                 205             


Arg Ile Ser Gln Lys Ser Ala Glu Asn Gly Arg Gly Gly Arg Val Leu 
    210                 215                 220                 


Lys Pro Val Arg Pro Leu Leu Leu Pro Arg Ala Ala Gly Glu Pro Leu 
225                 230                 235                 240 


Pro Thr Gln Arg Gly Ala Gln Glu Lys Met Gly Thr Pro Ala Glu Gln 
                245                 250                 255     


Ala Gln Gly Glu Arg Asn Val Pro Pro Pro Lys Ser Pro Leu Arg Leu 
            260                 265                 270         


Ile Ala Asn Ala Ile Arg Arg Ser Leu Glu Pro Leu Leu Ser Asn Ser 
        275                 280                 285             


Glu Gly Gly Lys Lys Ala Trp Ala Lys Gln Glu Ser Lys Thr Leu Pro 
    290                 295                 300                 


Ala Gln Ala Cys Thr Arg Ser Phe Ser Leu Arg Lys Thr Asn Ser Asn 
305                 310                 315                 320 


Lys Asp Gly Asp Gln His Ser Pro Gly Arg Asn Gln Ser Ser Ala Phe 
                325                 330                 335     


Ser Pro Pro Asp Pro Ala Leu Arg Thr His Ser Leu Pro Asn Arg Pro 
            340                 345                 350         


Ser Lys Val Phe Pro Ala Leu Arg Ser Pro Pro Cys Ser Lys Ile Glu 
        355                 360                 365             


Asp Val Pro Thr Leu Leu Glu Lys Val Ser Leu Gln Glu Asn Phe Pro 
    370                 375                 380                 


Asp Ala Ser Lys Pro Pro Lys Lys Arg Ile Ser Leu Phe Ser Ser Leu 
385                 390                 395                 400 


Arg Leu Lys Asp Lys Ser Phe Glu Ser Phe Leu Gln Glu Ser Arg Gln 
                405                 410                 415     


Arg Lys Asp Ile Arg Asp Leu Phe Gly Ser Pro Lys Arg Lys Val Leu 
            420                 425                 430         


Pro Glu Asp Ser Ala Gln Ala Leu Glu Lys Leu Leu Gln Pro Phe Lys 
        435                 440                 445             


Ser Thr Ser Leu Arg Gln Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro 
    450                 455                 460                 


Pro Pro Pro Pro Pro Pro Thr Ala Gly Gly Ala Asp Ser Lys Asn Phe 
465                 470                 475                 480 


Pro Leu Arg Ala Gln Val Thr Glu Ala Ser Ser Ser Ala Ser Ser Thr 
                485                 490                 495     


Ser Ser Ser Ser Ala Asp Glu Glu Phe Asp Pro Gln Leu Ser Leu Gln 
            500                 505                 510         


Leu Lys Glu Lys Lys Thr Leu Arg Arg Arg Lys Lys Leu Glu Lys Ala 
        515                 520                 525             


Met Lys Gln Leu Val Lys Gln Glu Glu Leu Lys Arg Leu Tyr Lys Ala 
    530                 535                 540                 


Gln Ala Ile Gln Arg Gln Leu Glu Glu Val Glu Glu Arg Gln Arg Ala 
545                 550                 555                 560 


Ser Glu Ile Gln Gly Val Arg Leu Glu Lys Ala Leu Arg Gly Glu Ala 
                565                 570                 575     


Asp Ser Gly Thr Gln Asp Glu Ala Gln Leu Leu Gln Glu Trp Phe Lys 
            580                 585                 590         


Leu Val Leu Glu Lys Asn Lys Leu Met Arg Tyr Glu Ser Glu Leu Leu 
        595                 600                 605             


Ile Met Ala Gln Glu Leu Glu Leu Glu Asp His Gln Ser Arg Leu Glu 
    610                 615                 620                 


Gln Lys Leu Arg Glu Lys Met Leu Lys Glu Glu Ser Gln Lys Asp Glu 
625                 630                 635                 640 


Lys Asp Leu Asn Glu Glu Gln Glu Val Phe Thr Glu Leu Met Gln Val 
                645                 650                 655     


Ile Glu Gln Arg Asp Lys Leu Val Asp Ser Leu Glu Glu Gln Arg Ile 
            660                 665                 670         


Arg Glu Lys Ala Glu Asp Gln His Phe Glu Ser Phe Val Phe Ser Arg 
        675                 680                 685             


Gly Cys Gln Leu Ser Arg Thr 
    690                 695 


<210>  213
<211>  85
<212>  DNA
<213>  Homo sapiens

<400>  213
atggtgttat caagtgtaac agcaactcca tgtggactgt gtaccaattt ccagtggaga       60

tgctgttact tttgatggtt accaa                                             85


<210>  214
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  214
atcattcaga aatggtatac aggaaaatga cctatgaatt gacagacaat atagctgagt       60

ttgtctgtca tttctttagg ccaatattct gtatgactgt gctacttcaa                 110


<210>  215
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  215
cgcctcctac cgcagtgctt gacgggaggc ggagcgggga acgaggccgt cggccatttt       60

gtgtctgctt cctgtgggac gtggtggtag ccgt                                   94


<210>  216
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  216
aggctgaggt agtagtttgt acagtttgag ggtctatgat accacccggt acaggagata       60

actgtacagg ccactgcctt gcca                                              84


<210>  217
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  217
ccttggagta aagtagcagc acataatggt ttgtggattt tgaaaaggtg caggccatat       60

tgtgctgcct caaaaataca agg                                               83


<210>  218
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  218
gtcagcagtg ccttagcagc acgtaaatat tggcgttaag attctaaaat tatctccagt       60

attaactgtg ctgctgaagt aaggttgac                                         89


<210>  219
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  219
gttccactct agcagcacgt aaatattggc gtagtgaaat atatattaaa caccaatatt       60

actgtgctgc tttagtgtga c                                                 81


<210>  220
<211>  2554
<212>  DNA
<213>  Homo sapiens

<400>  220
ggattggctg ttcggagcgg cgaggggctt ggcgggagct tccagtcgct cgagagcgga       60

gagcggcacc atggccccgc gggggcggcg gcggccgcgg cctcacaggt ctgagggcgc      120

aagacgttca aagaacactt tagaaagaac acattccatg aaagataaag ctggtcaaaa      180

gtgcaagcct attgacgtgt tcgactttcc tgataattct gatgtctcaa gcattggcag      240

gctgggtgaa aatgagaaag atgaagaaac ttatgagacc tttgatcctc ctttacatag      300

cacagctata tatgctgatg aagaagaatt ctccaaacat tgtggactgt ctctctcttc      360

aactcctcca ggaaaagaag caaaaagaag ttcagacact tctggaaatg aagcaagtga      420

aatcgaatct gtaaaaatta gtgcaaaaaa gccaggaaga aagctcaggc ccattagtga      480

tgactctgaa agcattgaag aaagtgatac aaggagaaaa gttaaatcag cagagaaaat      540

aagtacacaa cgtcatgagg ttattcgaac cacagcgtct tcagaacttt cagagaaacc      600

agctgagtct gtcacttcta aaaagacagg accccttagt gcccagccct ctgttgaaaa      660

agagaacttg gcaatagaaa gtcaatcgaa aactcagaaa aaagggaaga tatctcatga      720

caaaaggaag aaatcaagaa gtaaagccat aggctcagat acttctgaca ttgtgcacat      780

ttggtgtcca gaaggaatga aaaccagtga catcaaggag ttgaatattg ttttgcctga      840

atttgagaaa acccacctag agcatcaaca aagaatagaa tctaaagttt gtaaggcagc      900

catcgccaca ttttatgtta atgttaaaga acaattcatc aaaatgctta aagaaagcca      960

gatgttgaca aatctgaaaa ggaagaatgc taagatgatt tcagatatcg aaaagaaaag     1020

gcagcgtatg attgaagtcc aggatgaact gcttcggtta gagccacagc tgaaacaact     1080

acaaacaaaa tatgatgaac ttaaagagag aaagtcttcc cttaggaatg cagcatattt     1140

cttatctaat ttaaaacagc tttatcaaga ttattcagat gttcaagctc aagaaccaaa     1200

cgtaaaggaa acgtatgatt catccagcct tccagctctg ttatttaaag caagaacact     1260

tctgggagcc gaaagccatc tgcgaaatat caaccatcag ttagagaagc tccttgacca     1320

gggatgagaa gagcagtcta ctaaaatgtg cctataggaa gactagtctc atgctgttac     1380

cttctgaaac tgtaccttta taaatcaatt gttttgcaaa gaagttatgg cctacttaga     1440

atctaaaatt tgttattcaa attaaatggc tgtgaacaat gttaaatagc atcagtttgt     1500

ccaatagttt taaaggccat aatcatcttt tctggttaat atcttgagta attttaaaat     1560

gttgacacct taatcggtcc caggtatgag ctataataaa cttgtaaaat taagttgatg     1620

tgaacataat tttgattaat taataaggcg atttctcctg aatttacacc aaagctaatt     1680

tttaatgaaa ttggtttaca gaagtaaaaa acaaaaattg gaaagcaaag taataaaact     1740

tagtttatat aaacaggttg aatgatatat ttatcaaatc tcacagacat caggcaaatt     1800

atagcctggt gacaaaagtg ttcatagtga attagttact cttgtaatac ttctataatt     1860

agttcatcag gaatttcatc cacttcactg ttataactga gaagactgtt ctctgcagct     1920

tcagctaatt cagcatcttc agtagcttct aaaaaataag catcatcaat gccattatcc     1980

cagacagcat cagcagatgc acctgttgac agcctgctag gtgatggttt atgaggattc     2040

tgggtttcat tgctcctagt ttcatctgct tcatctgttg taaactcttc ttcctttatt     2100

tcagtggtga agggatagag agtgggatag gaaaatattt actcaggata tgtgatttaa     2160

ccttatactc tatgttgaag taaggtatta agtgacagat actaaagtga atatgcagga     2220

ggaatgctgt ctccgatatc tcaccgtggg aatgagtgca ctgattcaaa cgttgctgca     2280

ctgaagctca gacacacttg aaactccaaa tttgaaatta cctacagttc tgtgcacata     2340

cttttcaata ctccccgacg gaagagcaag ggtggattta attttttaac aagtggacag     2400

tccagctgaa gacaaatcag aagataaatt tgctatcttg acaatggact tagtacccat     2460

gctttaaatt ttaaagtatt tagcaaatcg taaacatgga ttgaaaaaag attaaaaaca     2520

gttgccaaaa tatgactgga ttgtatatta aaaa                                 2554


<210>  221
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Ala Pro Arg Gly Arg Arg Arg Pro Arg Pro His Arg Ser Glu Gly 
1               5                   10                  15      


Ala Arg Arg Ser Lys Asn Thr Leu Glu Arg Thr His Ser Met Lys Asp 
            20                  25                  30          


Lys Ala Gly Gln Lys Cys Lys Pro Ile Asp Val Phe Asp Phe Pro Asp 
        35                  40                  45              


Asn Ser Asp Val Ser Ser Ile Gly Arg Leu Gly Glu Asn Glu Lys Asp 
    50                  55                  60                  


Glu Glu Thr Tyr Glu Thr Phe Asp Pro Pro Leu His Ser Thr Ala Ile 
65                  70                  75                  80  


Tyr Ala Asp Glu Glu Glu Phe Ser Lys His Cys Gly Leu Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Pro Gly Lys Glu Ala Lys Arg Ser Ser Asp Thr Ser Gly 
            100                 105                 110         


Asn Glu Ala Ser Glu Ile Glu Ser Val Lys Ile Ser Ala Lys Lys Pro 
        115                 120                 125             


Gly Arg Lys Leu Arg Pro Ile Ser Asp Asp Ser Glu Ser Ile Glu Glu 
    130                 135                 140                 


Ser Asp Thr Arg Arg Lys Val Lys Ser Ala Glu Lys Ile Ser Thr Gln 
145                 150                 155                 160 


Arg His Glu Val Ile Arg Thr Thr Ala Ser Ser Glu Leu Ser Glu Lys 
                165                 170                 175     


Pro Ala Glu Ser Val Thr Ser Lys Lys Thr Gly Pro Leu Ser Ala Gln 
            180                 185                 190         


Pro Ser Val Glu Lys Glu Asn Leu Ala Ile Glu Ser Gln Ser Lys Thr 
        195                 200                 205             


Gln Lys Lys Gly Lys Ile Ser His Asp Lys Arg Lys Lys Ser Arg Ser 
    210                 215                 220                 


Lys Ala Ile Gly Ser Asp Thr Ser Asp Ile Val His Ile Trp Cys Pro 
225                 230                 235                 240 


Glu Gly Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro 
                245                 250                 255     


Glu Phe Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys 
            260                 265                 270         


Val Cys Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln 
        275                 280                 285             


Phe Ile Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg 
    290                 295                 300                 


Lys Asn Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met 
305                 310                 315                 320 


Ile Glu Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln 
                325                 330                 335     


Leu Gln Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg 
            340                 345                 350         


Asn Ala Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr 
        355                 360                 365             


Ser Asp Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser 
    370                 375                 380                 


Ser Ser Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala 
385                 390                 395                 400 


Glu Ser His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp 
                405                 410                 415     


Gln Gly 
        


<210>  222
<211>  6725
<212>  DNA
<213>  Homo sapiens

<400>  222
cgccgccatt ttcccagagc gagaggcagt gacactgagc gggcgcaggg ggccgagtcg       60

gagaccgtgc cggagttcgg gagcggcaac agagtgggca tagacactcc gagcagcctc      120

gccgtcgtct ctgcgttcct gttgactgcc tggctgcccc ctcccctact cctcggttcc      180

tggtgaagag gctgcgcgct gctgtttggg gagggggtgt gtggagccgg gtcctgtgtc      240

cgcagtggct gctgtcgggg ggtcgcctgt tcgcggaggt gcggagagac tccttggggg      300

tcgagcactg tggctggcat gccccagtgt tttggatacc aatgcatagg actccatagt      360

aatcgaattt accagaggcg aacgtcatga gcatagtgat cccattgggg gttgatacag      420

cagagacgtc atacttggaa atggctgcag gttcagaacc agaatccgta gaagctagcc      480

ctgtggtagt tgagaaatcc aacagttatc cccaccagtt atataccagc agctcacatc      540

attcacacag ttacattggt ttgccctatg cggaccataa ttatggtgct cgtcctcctc      600

cgacacctcc ggcttcccct cctccatcag tccttattag caaaaatgaa gtaggcatat      660

ttaccactcc taattttgat gaaacttcca gtgctactac aatcagcaca tctgaggatg      720

gaagttatgg tactgatgta accaggtgca tatgtggttt tacacatgat gatggataca      780

tgatctgttg tgacaaatgc agcgtttggc aacatattga ctgcatgggg attgataggc      840

agcatattcc tgatacatat ctatgtgaac gttgtcagcc taggaatttg gataaagaga      900

gggcagtgct actacaacgc cggaaaaggg aaaatatgtc agatggtgat accagtgcaa      960

ctgagagtgg tgatgaggtt cctgtggaat tatatactgc atttcagcat actccaacat     1020

caattacttt aactgcttca agagtttcca aagttaatga taaaagaagg aaaaaaagcg     1080

gggagaaaga acaacacatt tcaaaatgta aaaaggcatt tcgtgaagga tctaggaagt     1140

catcaagagt taagggttca gctccagaga ttgatccttc atctgatggt tcaaattttg     1200

gatgggagac aaagatcaaa gcatggatgg atcgatatga agaagcaaat aacaaccagt     1260

acagtgaggg tgttcagagg gaggcacaaa gaatagctct gagattaggc aatggaaatg     1320

acaaaaaaga gatgaataaa tccgatttga ataccaacaa tttgctcttc aaacctcctg     1380

tagagagcca tatacaaaag aataagaaaa ttcttaaatc tgcaaaagat ttgcctcctg     1440

atgcacttat cattgaatac agagggaagt ttatgctgag agaacagttt gaagcaaatg     1500

ggtatttctt taaaagacca tacccttttg tgttattcta ctctaaattt catgggctag     1560

aaatgtgtgt tgatgcaagg acttttggga atgaggctcg attcatcagg cggtcttgta     1620

cacccaatgc agaggtgagg catgaaattc aagatggaac catacatctt tatatttatt     1680

ctatacacag tattccaaag ggaactgaaa ttactattgc ctttgatttt gactatggaa     1740

attgtaagta caaggtggac tgtgcatgcc tcaaagaaaa cccagagtgc cctgttctaa     1800

aacgtagttc tgaatccatg gaaaatatca atagtggtta tgagaccaga cggaaaaaag     1860

gaaaaaaaga caaagatatt tcaaaagaaa aagatacaca aaatcagaat attactttgg     1920

attgtgaagg aacgaccaac aaaatgaaga gcccagaaac taaacaaaga aagctttctc     1980

cactgagact atcagtatca aataatcagg aaccagattt tattgatgat atagaagaaa     2040

aaactcctat tagtaatgaa gtagaaatgg aatcagagga gcagattgca gaaaggaaaa     2100

ggaagatgac aagagaagaa agaaaaatgg aagcaatttt gcaagctttt gccagacttg     2160

aaaagagaga gaaaagaaga gaacaagctt tggaaaggat cagcacagcc aaaactgaag     2220

ttaaaactga atgtaaagat acacagattg tcagtgatgc tgaagttatt caggaacaag     2280

caaaagaaga aaatgctagc aagccaaccc ctgccaaagt aaatagaact aaacagagaa     2340

aaagtttttc tcggagtagg actcacattg gacagcagcg tcggagacac agaactgtca     2400

gcatgtgttc agatatccag ccatcttctc ctgatataga agttacttca caacaaaatg     2460

atattgaaaa tactgtactt acaatagaac cagaaactga aactgcacta gcagaaataa     2520

ttactgaaac tgaagttcca gcacttaata aatgtcctac caagtacccc aaaacaaaga     2580

agcacttggt taatgaatgg ttaagtgaga agaatgagaa gacaggaaaa ccttcagatg     2640

gcctttcaga aaggcctcta cgcataacta cagatcctga agtgttagct acacaactca     2700

attctttacc aggtctcact tacagccccc atgtatactc cactcctaag cattatatta     2760

gatttacttc accattcctt tcagaaaaaa ggagaagaaa agaacctact gaaaacattt     2820

ctggttcatg caagaagcga tggttgaaac aagctctgga agaagaaaat tcagcaattt     2880

tacatagatt taattcaccc tgtcaagaaa gatccagaag tcctgcagtc aatggtgaaa     2940

ataaaagtcc actactatta aatgacagct gttcccttcc agatttaact acaccactaa     3000

aaaaacgaag attttatcag ttgctagatt cggtttactc agaaacctcc acacctactc     3060

cttccccgta tgctacacca actcacaccg atattactcc tatggaccca tcttttgcca     3120

cgcctccacg gataaaatca gatgatgaaa cttgtagaaa tggttataaa cccatatatt     3180

caccagttac cccagtaact cctggtacac caggaaatac catgcacttt gagaatattt     3240

cttccccaga aagttctcca gaaataaaga gacgcactta tagtcaagag ggatatgaca     3300

gatcttcaac catgttaaca ttggggcctt ttagaaattc taatttaact gaactgggtc     3360

tgcaagaaat aaagactatt ggttatacga gccctaggag taggactgaa gtcaacaggc     3420

agtgtcctgg agaaaaggaa cctgtgtcag accttcagct aggactcgat gcagttgagc     3480

caactgccct acataaaacc ctggaaacgc ctgcacatga cagggctgag cccaacagcc     3540

aactggactc gactcactct ggacggggca caatgtattc ttcctgggta aagagccctg     3600

acagaacagg agttaacttc tcagtgaact ccaacttgag ggacctgaca ccctcgcatc     3660

agttggaggt tggaggaggc ttccgaataa gtgagtcaaa gtgcctgatg caggatgata     3720

ctagaggcat gtttatggaa acaactgtgt tttgtacttc cgaagatggg cttgtatctg     3780

gtttcggacg gactgttaat gacaatttga tcgacgggaa ttgcacaccc cagaatccac     3840

cacaaaagaa aaaggtttct ctattagaat accgtaagag acaacgtgaa gctaggaaaa     3900

gtggctctaa gacagagaac tttccactca ttagtgtatc accccatgca agtggaagct     3960

tgagcaacaa tggtgatggc tgtgccagca gtaatgacaa tggggagcag gtggaccaca     4020

ctgctagcct acctttacca acaccagcta cagtttataa tgccacttct gaagaaacta     4080

gcaataactg ccctgttaag gatgctactg ctagtgagaa gaatgaacca gaagttcaat     4140

ggactgcctc aacttcagtg gaacaagtca gagaaaggag ttatcagaga gctttacttc     4200

tcagtgatca ccgaaaagat aaagatagtg ggggagaatc accatgtgtc tcatgttcac     4260

cgagtcatgt tcagtcttca ccttcatctc attcaaatca cataccccag ttgcaagcta     4320

agggcccagt cccttctttc agtgaactta tggaagaccc tgatcctgaa aatccagaac     4380

ccacaactac gaatgaatgt ccatccccag atacttctca aaatacttgt aaaagtcctc     4440

caaaaatgag caagcctggt tcacctggat ctgtaattcc tgctcaagca cacgggaaaa     4500

tattcacaaa accagatccc caatgggact ccacagttag tgcatccgaa gctgaaaatg     4560

gtgttcacct aaaaacagag ctccaacaaa aacagctatc aaataacaac caagcacttt     4620

caaagaatca tcctcctcag acacacgttc gtaattcatc tgagcaactt tcacaaaagc     4680

tgccttctgt gccaacaaag ttgcactgtc ctccatcacc tcacctagaa aatcctccaa     4740

agtcatccac gcctcacaca cctgtacagc atggttatct ttcaccaaag cctccttcac     4800

agcagttagg atctccctac aggcctcatc attcacagtc acctcaagtt ggaacacctc     4860

agcgagagcc tcaaagaaac ttttatccag cagcacagaa ccttccagcc aatactcagc     4920

aggcaacttc tggaacatta tttacacaga caccctcagg acaatcttca gcaacataca     4980

gtcagtttaa ccaacaaagt ctgaacagca cggcaccacc ccctccacct cctccacctc     5040

cttcttcgtc ttactatcaa aaccagcagc cctctgcaaa ctttcagaat tataatcagc     5100

tcaaaggtag tctttctcaa caaactgtgt ttacatcagg accaaatcaa gcacttcctg     5160

gcaccacaag ccagcaaaca gttccaggac accacgtgac tccagggcat tttttgccct     5220

ctcagaaccc taccattcac catcaaactg ctgctgccgt agtcccccct cctcctccac     5280

caccacctgc tccaggaccg caccttgtac aacagccgaa ttcccatcag caacactctg     5340

tagcacatgt agtagggcct gttcatgcgg tcacccctgg gtcgcatatt cattctcaaa     5400

ctgctggaca ccacttaccc ccacccccac cccctcctgg tcctgcccct catcaccatc     5460

caccacccca tccatccaca ggactccaag gtctacaagc acaacaccag catgttgtaa     5520

attcagcacc cccaccaccc cctccgccgc caccttccag tgttttggct tctgggcatc     5580

ataccacatc agctcaagcc ttacaccacc cacctcatca aggacctcca ctttttcctt     5640

cgagtgctca tccaactgta ccaccgtatc cctcacaagc tacacatcat accactttgg     5700

gaccgggacc ccagcaccag ccttctggaa cagggccaca ttgtccatta cctgtcacag     5760

gtcctcatct ccagccccaa ggaccaaaca gtattccaac acctactgct tcagggttct     5820

gtcctcatcc tggctctgtg gccctgccac atggggttca aggacctcag caggcatctc     5880

cagtgcctgg acagattcca attcacagag cacaggtgcc accaacattt caaaacaatt     5940

accatgggtc agggtggcat taaaatggac tccaaaaaca tttttttaaa tgttctgtaa     6000

gataaactgt atatttcata tgtacctgtt aaggtacttt ttaaagcttg tacatgaacc     6060

tttgtataaa aaacaccagt gctctttcgt tgtatttttc tcatttttgc tttttaaaat     6120

tcctttaaaa aatgtgctgt taagccagta ttaggtatct ttattttgta agtgaacatt     6180

ccagctgttt ttttctggca gatctgatgc tgatttgatg ctgtatgatc tttttttttt     6240

ttttagttaa attcatttag tgaatgttct attattttat acatacacat taagtactca     6300

gctaagtaat ggcactatga ggattttttt tttctttcct gtcagcagca gttctgtgaa     6360

tgcatcttag gtataaaaat gcaatacaga tttttatatt ttggtgtgga catggctcat     6420

tttgttttac cagttatttg caagcaaaat gtaatttaat gtatagatga tttctaatgt     6480

ctcctgacaa actgtaaata ctgcatttct tttgcgtata taattgctta cagcttttct     6540

catttgatat atagcattgt acatatgaca agtcttttgc aaaactgtgt gatctttgtg     6600

aaagtagtac agtatatgac ctttaatttc ttttttattt taaatatact gtcacactga     6660

agcactggtt gggcatttta attcatgtta ataaatcaca attatgtcag ttttaaaaaa     6720

aaaaa                                                                 6725


<210>  223
<211>  1858
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Val  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Arg Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Ser  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Phe Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Glu Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  224
<211>  6873
<212>  DNA
<213>  Homo sapiens

<400>  224
cgccgccatt ttcccagagc gagaggcagt gacactgagc gggcgcaggg ggccgagtcg       60

gagaccgtgc cggagttcgg gagcggcaac agagtgggca tagacactcc gagcagcctc      120

gccgtcgtct ctgcgttcct gttgactgcc tggctgcccc ctcccctact cctcggttcc      180

tggtgaagag gctgcgcgct gctgtttggg gagggggtgt gtggagccgg gtcctgtgtc      240

cgcagtggct gctgtcgggg ggtcgcctgt tcgcggaggt gcggagagac tccttggggg      300

tcgagcacat aacggggttc gggtgtctcg tgtgtgaaca tcacaggtct attctggata      360

agcaggtttt gtgaagacat ttattctttc ttggacctca gatttaccag acatctcatg      420

ggtttgtgga tgcacttaga tgtttgcaat gagcactgtg gctggcatgc cccagtgttt      480

tggataccaa tgcataggac tccatagtaa tcgaatttac cagaggcgaa cgtcatgagc      540

atagtgatcc cattgggggt tgatacagca gagacgtcat acttggaaat ggctgcaggt      600

tcagaaccag aatccgtaga agctagccct gtggtagttg agaaatccaa cagttatccc      660

caccagttat ataccagcag ctcacatcat tcacacagtt acattggttt gccctatgcg      720

gaccataatt atggtgctcg tcctcctccg acacctccgg cttcccctcc tccatcagtc      780

cttattagca aaaatgaagt aggcatattt accactccta attttgatga aacttccagt      840

gctactacaa tcagcacatc tgaggatgga agttatggta ctgatgtaac caggtgcata      900

tgtggtttta cacatgatga tggatacatg atctgttgtg acaaatgcag cgtttggcaa      960

catattgact gcatggggat tgataggcag catattcctg atacatatct atgtgaacgt     1020

tgtcagccta ggaatttgga taaagagagg gcagtgctac tacaacgccg gaaaagggaa     1080

aatatgtcag atggtgatac cagtgcaact gagagtggtg atgaggttcc tgtggaatta     1140

tatactgcat ttcagcatac tccaacatca attactttaa ctgcttcaag agtttccaaa     1200

gttaatgata aaagaaggaa aaaaagcggg gagaaagaac aacacatttc aaaatgtaaa     1260

aaggcatttc gtgaaggatc taggaagtca tcaagagtta agggttcagc tccagagatt     1320

gatccttcat ctgatggttc aaattttgga tgggagacaa agatcaaagc atggatggat     1380

cgatatgaag aagcaaataa caaccagtac agtgagggtg ttcagaggga ggcacaaaga     1440

atagctctga gattaggcaa tggaaatgac aaaaaagaga tgaataaatc cgatttgaat     1500

accaacaatt tgctcttcaa acctcctgta gagagccata tacaaaagaa taagaaaatt     1560

cttaaatctg caaaagattt gcctcctgat gcacttatca ttgaatacag agggaagttt     1620

atgctgagag aacagtttga agcaaatggg tatttcttta aaagaccata cccttttgtg     1680

ttattctact ctaaatttca tgggctagaa atgtgtgttg atgcaaggac ttttgggaat     1740

gaggctcgat tcatcaggcg gtcttgtaca cccaatgcag aggtgaggca tgaaattcaa     1800

gatggaacca tacatcttta tatttattct atacacagta ttccaaaggg aactgaaatt     1860

actattgcct ttgattttga ctatggaaat tgtaagtaca aggtggactg tgcatgcctc     1920

aaagaaaacc cagagtgccc tgttctaaaa cgtagttctg aatccatgga aaatatcaat     1980

agtggttatg agaccagacg gaaaaaagga aaaaaagaca aagatatttc aaaagaaaaa     2040

gatacacaaa atcagaatat tactttggat tgtgaaggaa cgaccaacaa aatgaagagc     2100

ccagaaacta aacaaagaaa gctttctcca ctgagactat cagtatcaaa taatcaggaa     2160

ccagatttta ttgatgatat agaagaaaaa actcctatta gtaatgaagt agaaatggaa     2220

tcagaggagc agattgcaga aaggaaaagg aagatgacaa gagaagaaag aaaaatggaa     2280

gcaattttgc aagcttttgc cagacttgaa aagagagaga aaagaagaga acaagctttg     2340

gaaaggatca gcacagccaa aactgaagtt aaaactgaat gtaaagatac acagattgtc     2400

agtgatgctg aagttattca ggaacaagca aaagaagaaa atgctagcaa gccaacccct     2460

gccaaagtaa atagaactaa acagagaaaa agtttttctc ggagtaggac tcacattgga     2520

cagcagcgtc ggagacacag aactgtcagc atgtgttcag atatccagcc atcttctcct     2580

gatatagaag ttacttcaca acaaaatgat attgaaaata ctgtacttac aatagaacca     2640

gaaactgaaa ctgcactagc agaaataatt actgaaactg aagttccagc acttaataaa     2700

tgtcctacca agtaccccaa aacaaagaag cacttggtta atgaatggtt aagtgagaag     2760

aatgagaaga caggaaaacc ttcagatggc ctttcagaaa ggcctctacg cataactaca     2820

gatcctgaag tgttagctac acaactcaat tctttaccag gtctcactta cagcccccat     2880

gtatactcca ctcctaagca ttatattaga tttacttcac cattcctttc agaaaaaagg     2940

agaagaaaag aacctactga aaacatttct ggttcatgca agaagcgatg gttgaaacaa     3000

gctctggaag aagaaaattc agcaatttta catagattta attcaccctg tcaagaaaga     3060

tccagaagtc ctgcagtcaa tggtgaaaat aaaagtccac tactattaaa tgacagctgt     3120

tcccttccag atttaactac accactaaaa aaacgaagat tttatcagtt gctagattcg     3180

gtttactcag aaacctccac acctactcct tccccgtatg ctacaccaac tcacaccgat     3240

attactccta tggacccatc ttttgccacg cctccacgga taaaatcaga tgatgaaact     3300

tgtagaaatg gttataaacc catatattca ccagttaccc cagtaactcc tggtacacca     3360

ggaaatacca tgcactttga gaatatttct tccccagaaa gttctccaga aataaagaga     3420

cgcacttata gtcaagaggg atatgacaga tcttcaacca tgttaacatt ggggcctttt     3480

agaaattcta atttaactga actgggtctg caagaaataa agactattgg ttatacgagc     3540

cctaggagta ggactgaagt caacaggcag tgtcctggag aaaaggaacc tgtgtcagac     3600

cttcagctag gactcgatgc agttgagcca actgccctac ataaaaccct ggaaacgcct     3660

gcacatgaca gggctgagcc caacagccaa ctggactcga ctcactctgg acggggcaca     3720

atgtattctt cctgggtaaa gagccctgac agaacaggag ttaacttctc agtgaactcc     3780

aacttgaggg acctgacacc ctcgcatcag ttggaggttg gaggaggctt ccgaataagt     3840

gagtcaaagt gcctgatgca ggatgatact agaggcatgt ttatggaaac aactgtgttt     3900

tgtacttccg aagatgggct tgtatctggt ttcggacgga ctgttaatga caatttgatc     3960

gacgggaatt gcacacccca gaatccacca caaaagaaaa aggtttctct attagaatac     4020

cgtaagagac aacgtgaagc taggaaaagt ggctctaaga cagagaactt tccactcatt     4080

agtgtatcac cccatgcaag tggaagcttg agcaacaatg gtgatggctg tgccagcagt     4140

aatgacaatg gggagcaggt ggaccacact gctagcctac ctttaccaac accagctaca     4200

gtttataatg ccacttctga agaaactagc aataactgcc ctgttaagga tgctactgct     4260

agtgagaaga atgaaccaga agttcaatgg actgcctcaa cttcagtgga acaagtcaga     4320

gaaaggagtt atcagagagc tttacttctc agtgatcacc gaaaagataa agatagtggg     4380

ggagaatcac catgtgtctc atgttcaccg agtcatgttc agtcttcacc ttcatctcat     4440

tcaaatcaca taccccagtt gcaagctaag ggcccagtcc cttctttcag tgaacttatg     4500

gaagaccctg atcctgaaaa tccagaaccc acaactacga atgaatgtcc atccccagat     4560

acttctcaaa atacttgtaa aagtcctcca aaaatgagca agcctggttc acctggatct     4620

gtaattcctg ctcaagcaca cgggaaaata ttcacaaaac cagatcccca atgggactcc     4680

acagttagtg catccgaagc tgaaaatggt gttcacctaa aaacagagct ccaacaaaaa     4740

cagctatcaa ataacaacca agcactttca aagaatcatc ctcctcagac acacgttcgt     4800

aattcatctg agcaactttc acaaaagctg ccttctgtgc caacaaagtt gcactgtcct     4860

ccatcacctc acctagaaaa tcctccaaag tcatccacgc ctcacacacc tgtacagcat     4920

ggttatcttt caccaaagcc tccttcacag cagttaggat ctccctacag gcctcatcat     4980

tcacagtcac ctcaagttgg aacacctcag cgagagcctc aaagaaactt ttatccagca     5040

gcacagaacc ttccagccaa tactcagcag gcaacttctg gaacattatt tacacagaca     5100

ccctcaggac aatcttcagc aacatacagt cagtttaacc aacaaagtct gaacagcacg     5160

gcaccacccc ctccacctcc tccacctcct tcttcgtctt actatcaaaa ccagcagccc     5220

tctgcaaact ttcagaatta taatcagctc aaaggtagtc tttctcaaca aactgtgttt     5280

acatcaggac caaatcaagc acttcctggc accacaagcc agcaaacagt tccaggacac     5340

cacgtgactc cagggcattt tttgccctct cagaacccta ccattcacca tcaaactgct     5400

gctgccgtag tcccccctcc tcctccacca ccacctgctc caggaccgca ccttgtacaa     5460

cagccgaatt cccatcagca acactctgta gcacatgtag tagggcctgt tcatgcggtc     5520

acccctgggt cgcatattca ttctcaaact gctggacacc acttaccccc acccccaccc     5580

cctcctggtc ctgcccctca tcaccatcca ccaccccatc catccacagg actccaaggt     5640

ctacaagcac aacaccagca tgttgtaaat tcagcacccc caccaccccc tccgccgcca     5700

ccttccagtg ttttggcttc tgggcatcat accacatcag ctcaagcctt acaccaccca     5760

cctcatcaag gacctccact ttttccttcg agtgctcatc caactgtacc accgtatccc     5820

tcacaagcta cacatcatac cactttggga ccgggacccc agcaccagcc ttctggaaca     5880

gggccacatt gtccattacc tgtcacaggt cctcatctcc agccccaagg accaaacagt     5940

attccaacac ctactgcttc agggttctgt cctcatcctg gctctgtggc cctgccacat     6000

ggggttcaag gacctcagca ggcatctcca gtgcctggac agattccaat tcacagagca     6060

caggtgccac caacatttca aaacaattac catgggtcag ggtggcatta aaatggactc     6120

caaaaacatt tttttaaatg ttctgtaaga taaactgtat atttcatatg tacctgttaa     6180

ggtacttttt aaagcttgta catgaacctt tgtataaaaa acaccagtgc tctttcgttg     6240

tatttttctc atttttgctt tttaaaattc ctttaaaaaa tgtgctgtta agccagtatt     6300

aggtatcttt attttgtaag tgaacattcc agctgttttt ttctggcaga tctgatgctg     6360

atttgatgct gtatgatctt tttttttttt ttagttaaat tcatttagtg aatgttctat     6420

tattttatac atacacatta agtactcagc taagtaatgg cactatgagg attttttttt     6480

tctttcctgt cagcagcagt tctgtgaatg catcttaggt ataaaaatgc aatacagatt     6540

tttatatttt ggtgtggaca tggctcattt tgttttacca gttatttgca agcaaaatgt     6600

aatttaatgt atagatgatt tctaatgtct cctgacaaac tgtaaatact gcatttcttt     6660

tgcgtatata attgcttaca gcttttctca tttgatatat agcattgtac atatgacaag     6720

tcttttgcaa aactgtgtga tctttgtgaa agtagtacag tatatgacct ttaatttctt     6780

ttttatttta aatatactgt cacactgaag cactggttgg gcattttaat tcatgttaat     6840

aaatcacaat tatgtcagtt ttaaaaaaaa aaa                                  6873


<210>  225
<211>  1858
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Val  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Arg Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Ser  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Phe Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Glu Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  226
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  226
gagcacgtgc gcgtcctcgc tgctcacatt tcggcggagg gcgcgctccc tggaaaattc       60

cactcctgtg ctagctccac cctatgcggc ttttctccta cccgacgctc ttcactctca      120

gctcccttcc cggcggcctt tgcgggaaca agatggcagc ccccatacct caagggttct      180

cttgtttatc gagggttttg ggctggtggt ctcggcagcc agttctggtg actcagtccg      240

cagctatagt tccagtaaga actaaaaaac gtttcacacc tcctatttat caacctaaat      300

ttaaaacaga aaaggagttt atgcaacatg cccggaaagc aggattggtt attcctccag      360

aaaaatcgga ccgttccata catctggcct gtacagctgg tatatttgat gcctatgttc      420

ctcctgaggg tgatgcacgc atatcatctc tttcaaagga gggactgata gagagaactg      480

aacgaatgaa gaagactatg gcatcacaag tgtcaatccg gaggataaaa gactatgatg      540

ccaactttaa aataaaggac ttccctgaaa aagctaagga tatctttatt gaagctcacc      600

tttgtctaaa taactcagac catgaccgac ttcatacctt ggtaactgaa cactgttttc      660

cagacatgac ttgggacatc aaatataaga ccgtccgctg gagctttgtg gaatctttag      720

agccctctca tgttgttcaa gttcgctgtt caagtatgat gaaccagggc aacgtgtacg      780

gccagatcac cgtacgcatg cacacccggc agactctggc catctatgac cggtttggcc      840

ggttgatgta tggacaggaa gatgtaccca aggatgtcct ggagtatgtt gtattcgaaa      900

agcagttgac aaacccctat ggaagctgga gaatgcatac caagatcgtt cccccatggg      960

caccccctaa gcagcccatc cttaagacgg tgatgatccc tggccctcag ctgaaaccag     1020

aagaagaata tgaagaggca caaggagagg cccagaagcc tcagctagcc tgatgacaaa     1080

aatgacttct agggtgaagc ctgggtgatg aggctgctgg aagctttgaa gtctcccatt     1140

cccctcatgc tataaaaaga actacctttg ttctctccca tcctgctcag gtcttttcag     1200

cagtctcatc atcagcaacc atgactgatg actgggccct agcaggtggc aggtataaca     1260

tggccatgga cactcttctt ttttaaattt tatgtctagc ttctgagtct agatgaaaga     1320

cagtatgttt cagagaacat tggatatcag tttttcccac agcagggact gtgagagaca     1380

accagcagca tcctctttgt aatcacaggg cagggatcag agtttgaaat gaaatgttgt     1440

cagggtgttg gaaaaatttt ggtgagttct gcacatttcc cctggttcag gctgggcatg     1500

gaccagcctt cagatggcag aagtggaaga tgagcctact tgtgagcgat gtgactttaa     1560

ggaaatgaag actggggaag aataattagt gtttataaga catttaagag gccctttttc     1620

atatactgac tcactgatga atcagcattt gcattttatg gaaaaatata aatccaaaga     1680

aataatttat cccttaaaaa aaaaaaaaaa aaa                                  1713


<210>  227
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ala Ala Pro Ile Pro Gln Gly Phe Ser Cys Leu Ser Arg Val Leu 
1               5                   10                  15      


Gly Trp Trp Ser Arg Gln Pro Val Leu Val Thr Gln Ser Ala Ala Ile 
            20                  25                  30          


Val Pro Val Arg Thr Lys Lys Arg Phe Thr Pro Pro Ile Tyr Gln Pro 
        35                  40                  45              


Lys Phe Lys Thr Glu Lys Glu Phe Met Gln His Ala Arg Lys Ala Gly 
    50                  55                  60                  


Leu Val Ile Pro Pro Glu Lys Ser Asp Arg Ser Ile His Leu Ala Cys 
65                  70                  75                  80  


Thr Ala Gly Ile Phe Asp Ala Tyr Val Pro Pro Glu Gly Asp Ala Arg 
                85                  90                  95      


Ile Ser Ser Leu Ser Lys Glu Gly Leu Ile Glu Arg Thr Glu Arg Met 
            100                 105                 110         


Lys Lys Thr Met Ala Ser Gln Val Ser Ile Arg Arg Ile Lys Asp Tyr 
        115                 120                 125             


Asp Ala Asn Phe Lys Ile Lys Asp Phe Pro Glu Lys Ala Lys Asp Ile 
    130                 135                 140                 


Phe Ile Glu Ala His Leu Cys Leu Asn Asn Ser Asp His Asp Arg Leu 
145                 150                 155                 160 


His Thr Leu Val Thr Glu His Cys Phe Pro Asp Met Thr Trp Asp Ile 
                165                 170                 175     


Lys Tyr Lys Thr Val Arg Trp Ser Phe Val Glu Ser Leu Glu Pro Ser 
            180                 185                 190         


His Val Val Gln Val Arg Cys Ser Ser Met Met Asn Gln Gly Asn Val 
        195                 200                 205             


Tyr Gly Gln Ile Thr Val Arg Met His Thr Arg Gln Thr Leu Ala Ile 
    210                 215                 220                 


Tyr Asp Arg Phe Gly Arg Leu Met Tyr Gly Gln Glu Asp Val Pro Lys 
225                 230                 235                 240 


Asp Val Leu Glu Tyr Val Val Phe Glu Lys Gln Leu Thr Asn Pro Tyr 
                245                 250                 255     


Gly Ser Trp Arg Met His Thr Lys Ile Val Pro Pro Trp Ala Pro Pro 
            260                 265                 270         


Lys Gln Pro Ile Leu Lys Thr Val Met Ile Pro Gly Pro Gln Leu Lys 
        275                 280                 285             


Pro Glu Glu Glu Tyr Glu Glu Ala Gln Gly Glu Ala Gln Lys Pro Gln 
    290                 295                 300                 


Leu Ala 
305     


<210>  228
<211>  1536
<212>  DNA
<213>  Homo sapiens

<400>  228
agcttctccc ccatgccttc cctttcacgc ttccgtcctg acgcaaacgt ggggccgcct       60

tccgcactgc gggcttgtcc ttggccctgc cctactcagt ttcctgaagc atgcgcagtt      120

gcctttccgt caattcctgt cctgggcgta cgtcaagatg gcggcgtctg tattaaacac      180

cgtgctgagg cggcttccta tgctatctct cttccgaggt tctcacagag ttcaggttcc      240

cctccagact ctttgcacca aagctccctc tgaggaagat tctttgtcct cagttcccat      300

ttctccttat aaggatgagc cctggaaata tctggaatca gaagaatacc aggagcgata      360

tggttctcgc cccgtctggg ctgactaccg ccgcaaccac aagggtggtg tacccccaca      420

gcggactcgg aagacatgta ttcgtcggaa taaagttgtt gggaatccct gccccatctg      480

tcgagatcac aagttgcatg ttgactttag gaacgtgaag ctcttggagc aatttgtctg      540

cgcccacacg ggtatcatct tctatgctcc atacacagga gtctgtgtga agcagcacaa      600

gcggttgacc caggccatcc agaaagccag ggatcatggt ctcctcattt accacatccc      660

ccaggttgaa ccacgggacc ttgacttcag tacctctcat ggggctgtga gtgctactcc      720

gccagccccc accctggtct caggtgaccc ctggtaccca tggtacaact ggaaacagcc      780

accggagaga gaactgtctc gccttcgccg gctttaccag ggtcatctcc aagaagagag      840

tggcccccca cctgagtcaa tgcccaagat gccccctaga acaccagcgg aagcctcctc      900

cactgggcag acaggccctc agagtgctct gtaggagctg tagactggga agagaggcca      960

ggcgtggtgg ctcactcctg taatcccagc actttgggaa gccaaggtgg gctgatcact     1020

tgatcccagg agtttgagac cagcctgggc accatggtga aacctcgtct ttaccaaaaa     1080

atacaaaaat tagctgggtg tggtggtgca cacctgtagt ctcaactatt ggggaggcta     1140

aggtaggatc acttgatccc aggaggcgga ggttgcagtg agttgcagtc acacccctgc     1200

actccagcct gggtgacagc tagaccctgt ctcaaaaaaa aaaaaaaaga ctgggaagag     1260

agctagaggg actaggagat aatgtgtatg taggtttatg tgatgggata tcaccctgaa     1320

gagttgtgtc ttttgtggcc agtgacaaat ccaggaaatg aatgttgctg atagggataa     1380

atcttgaggc tgagggcggg tggtacagat gtgtatggga aaccccaacc cctatatatt     1440

gtaaatagat gggctgggct aaacattgtt gccgtttcat acttctacca actcagcttt     1500

tacacaataa agctctactg tctctggttt gcttaa                               1536


<210>  229
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ala Ala Ser Val Leu Asn Thr Val Leu Arg Arg Leu Pro Met Leu 
1               5                   10                  15      


Ser Leu Phe Arg Gly Ser His Arg Val Gln Val Pro Leu Gln Thr Leu 
            20                  25                  30          


Cys Thr Lys Ala Pro Ser Glu Glu Asp Ser Leu Ser Ser Val Pro Ile 
        35                  40                  45              


Ser Pro Tyr Lys Asp Glu Pro Trp Lys Tyr Leu Glu Ser Glu Glu Tyr 
    50                  55                  60                  


Gln Glu Arg Tyr Gly Ser Arg Pro Val Trp Ala Asp Tyr Arg Arg Asn 
65                  70                  75                  80  


His Lys Gly Gly Val Pro Pro Gln Arg Thr Arg Lys Thr Cys Ile Arg 
                85                  90                  95      


Arg Asn Lys Val Val Gly Asn Pro Cys Pro Ile Cys Arg Asp His Lys 
            100                 105                 110         


Leu His Val Asp Phe Arg Asn Val Lys Leu Leu Glu Gln Phe Val Cys 
        115                 120                 125             


Ala His Thr Gly Ile Ile Phe Tyr Ala Pro Tyr Thr Gly Val Cys Val 
    130                 135                 140                 


Lys Gln His Lys Arg Leu Thr Gln Ala Ile Gln Lys Ala Arg Asp His 
145                 150                 155                 160 


Gly Leu Leu Ile Tyr His Ile Pro Gln Val Glu Pro Arg Asp Leu Asp 
                165                 170                 175     


Phe Ser Thr Ser His Gly Ala Val Ser Ala Thr Pro Pro Ala Pro Thr 
            180                 185                 190         


Leu Val Ser Gly Asp Pro Trp Tyr Pro Trp Tyr Asn Trp Lys Gln Pro 
        195                 200                 205             


Pro Glu Arg Glu Leu Ser Arg Leu Arg Arg Leu Tyr Gln Gly His Leu 
    210                 215                 220                 


Gln Glu Glu Ser Gly Pro Pro Pro Glu Ser Met Pro Lys Met Pro Pro 
225                 230                 235                 240 


Arg Thr Pro Ala Glu Ala Ser Ser Thr Gly Gln Thr Gly Pro Gln Ser 
                245                 250                 255     


Ala Leu 
        


<210>  230
<211>  3466
<212>  DNA
<213>  Homo sapiens

<400>  230
aattacggcc ggattccgga gtcctttcca gctccctctt cggccgggtt tcccgccgaa       60

tacaaaggcg cactgtgaac tggctctttc tttccgccaa tcatttccgc cagccattca      120

tcaccgattt tcttcatctt cccctccctc ttccgtcccg cagtccccga cctgttagct      180

ctcggttagt taagggactc gggtccttcc gaactgcgca tgcgccaccg cgtctgcagg      240

gggagaagcg ggcaggggcg caggcgcagt agtgtgatcc cctggccagt ccctaagcac      300

gtgggttggg ttgtcctgct tggctgcgga gggagtggaa cctcgatatt ggtggtgtcc      360

atcgtgggca gcggactaat aaaggccatg gcgccagcag aaatcctgaa cgggaaggag      420

atctccgcgc aaataagggc gagactgaaa aatcaagtca ctcagttgaa ggagcaagta      480

cctggtttca caccacgcct ggcaatatta caggttggca acagagatga ttccaatctt      540

tatataaatg tgaagctgaa ggctgctgaa gagattggga tcaaagccac tcacattaag      600

ttaccaagaa caaccacaga atctgaggtg atgaagtaca ttacatcttt gaatgaagac      660

tctactgtac atgggttctt agtgcagcta cctttagatt cagagaattc cattaacact      720

gaagaagtga tcaatgctat tgcacccgag aaggatgtgg atggattgac tagcatcaat      780

gctgggaaac ttgctagagg tgacctcaat gactgtttca ttccttgtac gcctaaggga      840

tgcttggaac tcatcaaaga gacaggggtg ccgattgccg gaaggcatgc tgtggtggtt      900

gggcgcagta aaatagttgg ggccccgatg catgacttgc ttctgtggaa caatgccaca      960

gtgaccacct gccactccaa gactgcccat ctggatgagg aggtaaataa aggtgacatc     1020

ctggtggttg caactggtca gcctgaaatg gttaaagggg agtggatcaa acctggggca     1080

atagtcatcg actgtggaat caattatgtc ccagatgata aaaaaccaaa tgggagaaaa     1140

gttgtgggtg atgtggcata cgacgaggcc aaagagaggg cgagcttcat cactcctgtt     1200

cctggcggcg tagggcccat gacagttgca atgctcatgc agagcacagt agagagtgcc     1260

aagcgtttcc tggagaaatt taagccagga aagtggatga ttcagtataa caaccttaac     1320

ctcaagacac ctgttccaag tgacattgat atatcacgat cttgtaaacc gaagcccatt     1380

ggtaagctgg ctcgagaaat tggtctgctg tctgaagagg tagaattata tggtgaaaca     1440

aaggccaaag ttctgctgtc agcactagaa cgcctgaagc accggcctga tgggaaatac     1500

gtggtggtga ctggaataac tccaacaccc ctgggagaag ggaaaagcac aactacaatc     1560

gggctagtgc aagcccttgg tgcccatctc taccagaatg tctttgcgtg tgtgcgacag     1620

ccttctcagg gccccacctt tggaataaaa ggtggcgctg caggaggcgg ctactcccag     1680

gtcattccta tggaagagtt taatctccac ctcacaggtg acatccatgc catcactgca     1740

gctaataacc tcgttgctgc ggccattgat gctcggatat ttcatgaact gacccagaca     1800

gacaaggctc tctttaatcg tttggtgcca tcagtaaatg gagtgagaag gttctctgac     1860

atccaaatcc gaaggttaaa gagactaggc attgaaaaga ctgaccctac cacactgaca     1920

gatgaagaga taaacagatt tgcaagattg gacattgatc cagaaaccat aacttggcaa     1980

agagtgttgg ataccaatga tagattcctg aggaagatca cgattggaca ggctccaacg     2040

gagaagggtc acacacggac ggcccagttt gatatctctg tggccagtga aattatggct     2100

gtcctggctc tcaccacttc tctagaagac atgagagaga gactgggcaa aatggtggtg     2160

gcatccagta agaaaggaga gcccgtcagt gccgaagatc tgggggtgag tggtgcactg     2220

acagtgctta tgaaggacgc aatcaagccc aatctcatgc agacactgga gggcactcca     2280

gtgtttgtcc atgctggccc gtttgccaac atcgcacatg gcaattcctc catcattgca     2340

gaccggatcg cactcaagct tgttggccca gaagggtttg tagtgacgga agcaggattt     2400

ggagcagaca ttggaatgga aaagtttttt aacatcaaat gccggtattc cggcctctgc     2460

ccccacgtgg tggtgcttgt tgccactgtc agggctctca agatgcacgg gggcggcccc     2520

acggtcactg ctggactgcc tcttcccaag gcttacatac aggagaacct ggagctggtt     2580

gaaaaaggct tcagtaactt gaagaaacaa attgaaaatg ccagaatgtt tggaattcca     2640

gtagtagtgg ccgtgaatgc attcaagacg gatacagagt ctgagctgga cctcatcagc     2700

cgcctttcca gagaacatgg ggcttttgat gccgtgaagt gcactcactg ggcagaaggg     2760

ggcaagggtg ccttagccct ggctcaggcc gtccagagag cagcacaagc acccagcagc     2820

ttccagctcc tttatgacct caagctccca gttgaggata aaatcaggat cattgcacag     2880

aagatctatg gagcagatga cattgaatta cttcccgaag ctcaacacaa agctgaagtc     2940

tacacgaagc agggctttgg gaatctcccc atctgcatgg ctaaaacaca cttgtctttg     3000

tctcacaacc cagagcaaaa aggtgtccct acaggcttca ttctgcccat tcgcgacatc     3060

cgcgccagcg ttggggctgg ttttctgtac cccttagtag gaacgatgag cacaatgcct     3120

ggactcccca cccggccctg tttttatgat attgatttgg accctgaaac agaacaggtg     3180

aatggattat tctaaacaga tcaccatcca tcttcaagaa gctactttga aagtctggcc     3240

agtgtctatt caggcccact gggagttagg aagtataagt aagccaagag aagtcagccc     3300

ctgcccagaa gatctgaaac taatagtagg agtttcccca gaagtcattt tcagccttaa     3360

ttctcatcat gtataaatta acataaatca tgcatgtctg tttactttag tgacgttcca     3420

cagaataaaa ggaaacaagt ttgccatcaa aaaaaaaaaa aaaaaa                    3466


<210>  231
<211>  935
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Ala Pro Ala Glu Ile Leu Asn Gly Lys Glu Ile Ser Ala Gln Ile 
1               5                   10                  15      


Arg Ala Arg Leu Lys Asn Gln Val Thr Gln Leu Lys Glu Gln Val Pro 
            20                  25                  30          


Gly Phe Thr Pro Arg Leu Ala Ile Leu Gln Val Gly Asn Arg Asp Asp 
        35                  40                  45              


Ser Asn Leu Tyr Ile Asn Val Lys Leu Lys Ala Ala Glu Glu Ile Gly 
    50                  55                  60                  


Ile Lys Ala Thr His Ile Lys Leu Pro Arg Thr Thr Thr Glu Ser Glu 
65                  70                  75                  80  


Val Met Lys Tyr Ile Thr Ser Leu Asn Glu Asp Ser Thr Val His Gly 
                85                  90                  95      


Phe Leu Val Gln Leu Pro Leu Asp Ser Glu Asn Ser Ile Asn Thr Glu 
            100                 105                 110         


Glu Val Ile Asn Ala Ile Ala Pro Glu Lys Asp Val Asp Gly Leu Thr 
        115                 120                 125             


Ser Ile Asn Ala Gly Lys Leu Ala Arg Gly Asp Leu Asn Asp Cys Phe 
    130                 135                 140                 


Ile Pro Cys Thr Pro Lys Gly Cys Leu Glu Leu Ile Lys Glu Thr Gly 
145                 150                 155                 160 


Val Pro Ile Ala Gly Arg His Ala Val Val Val Gly Arg Ser Lys Ile 
                165                 170                 175     


Val Gly Ala Pro Met His Asp Leu Leu Leu Trp Asn Asn Ala Thr Val 
            180                 185                 190         


Thr Thr Cys His Ser Lys Thr Ala His Leu Asp Glu Glu Val Asn Lys 
        195                 200                 205             


Gly Asp Ile Leu Val Val Ala Thr Gly Gln Pro Glu Met Val Lys Gly 
    210                 215                 220                 


Glu Trp Ile Lys Pro Gly Ala Ile Val Ile Asp Cys Gly Ile Asn Tyr 
225                 230                 235                 240 


Val Pro Asp Asp Lys Lys Pro Asn Gly Arg Lys Val Val Gly Asp Val 
                245                 250                 255     


Ala Tyr Asp Glu Ala Lys Glu Arg Ala Ser Phe Ile Thr Pro Val Pro 
            260                 265                 270         


Gly Gly Val Gly Pro Met Thr Val Ala Met Leu Met Gln Ser Thr Val 
        275                 280                 285             


Glu Ser Ala Lys Arg Phe Leu Glu Lys Phe Lys Pro Gly Lys Trp Met 
    290                 295                 300                 


Ile Gln Tyr Asn Asn Leu Asn Leu Lys Thr Pro Val Pro Ser Asp Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Ser Cys Lys Pro Lys Pro Ile Gly Lys Leu Ala Arg 
                325                 330                 335     


Glu Ile Gly Leu Leu Ser Glu Glu Val Glu Leu Tyr Gly Glu Thr Lys 
            340                 345                 350         


Ala Lys Val Leu Leu Ser Ala Leu Glu Arg Leu Lys His Arg Pro Asp 
        355                 360                 365             


Gly Lys Tyr Val Val Val Thr Gly Ile Thr Pro Thr Pro Leu Gly Glu 
    370                 375                 380                 


Gly Lys Ser Thr Thr Thr Ile Gly Leu Val Gln Ala Leu Gly Ala His 
385                 390                 395                 400 


Leu Tyr Gln Asn Val Phe Ala Cys Val Arg Gln Pro Ser Gln Gly Pro 
                405                 410                 415     


Thr Phe Gly Ile Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ser Gln Val 
            420                 425                 430         


Ile Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala 
        435                 440                 445             


Ile Thr Ala Ala Asn Asn Leu Val Ala Ala Ala Ile Asp Ala Arg Ile 
    450                 455                 460                 


Phe His Glu Leu Thr Gln Thr Asp Lys Ala Leu Phe Asn Arg Leu Val 
465                 470                 475                 480 


Pro Ser Val Asn Gly Val Arg Arg Phe Ser Asp Ile Gln Ile Arg Arg 
                485                 490                 495     


Leu Lys Arg Leu Gly Ile Glu Lys Thr Asp Pro Thr Thr Leu Thr Asp 
            500                 505                 510         


Glu Glu Ile Asn Arg Phe Ala Arg Leu Asp Ile Asp Pro Glu Thr Ile 
        515                 520                 525             


Thr Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile 
    530                 535                 540                 


Thr Ile Gly Gln Ala Pro Thr Glu Lys Gly His Thr Arg Thr Ala Gln 
545                 550                 555                 560 


Phe Asp Ile Ser Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr 
                565                 570                 575     


Thr Ser Leu Glu Asp Met Arg Glu Arg Leu Gly Lys Met Val Val Ala 
            580                 585                 590         


Ser Ser Lys Lys Gly Glu Pro Val Ser Ala Glu Asp Leu Gly Val Ser 
        595                 600                 605             


Gly Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met 
    610                 615                 620                 


Gln Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala 
625                 630                 635                 640 


Asn Ile Ala His Gly Asn Ser Ser Ile Ile Ala Asp Arg Ile Ala Leu 
                645                 650                 655     


Lys Leu Val Gly Pro Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly 
            660                 665                 670         


Ala Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Tyr Ser 
        675                 680                 685             


Gly Leu Cys Pro His Val Val Val Leu Val Ala Thr Val Arg Ala Leu 
    690                 695                 700                 


Lys Met His Gly Gly Gly Pro Thr Val Thr Ala Gly Leu Pro Leu Pro 
705                 710                 715                 720 


Lys Ala Tyr Ile Gln Glu Asn Leu Glu Leu Val Glu Lys Gly Phe Ser 
                725                 730                 735     


Asn Leu Lys Lys Gln Ile Glu Asn Ala Arg Met Phe Gly Ile Pro Val 
            740                 745                 750         


Val Val Ala Val Asn Ala Phe Lys Thr Asp Thr Glu Ser Glu Leu Asp 
        755                 760                 765             


Leu Ile Ser Arg Leu Ser Arg Glu His Gly Ala Phe Asp Ala Val Lys 
    770                 775                 780                 


Cys Thr His Trp Ala Glu Gly Gly Lys Gly Ala Leu Ala Leu Ala Gln 
785                 790                 795                 800 


Ala Val Gln Arg Ala Ala Gln Ala Pro Ser Ser Phe Gln Leu Leu Tyr 
                805                 810                 815     


Asp Leu Lys Leu Pro Val Glu Asp Lys Ile Arg Ile Ile Ala Gln Lys 
            820                 825                 830         


Ile Tyr Gly Ala Asp Asp Ile Glu Leu Leu Pro Glu Ala Gln His Lys 
        835                 840                 845             


Ala Glu Val Tyr Thr Lys Gln Gly Phe Gly Asn Leu Pro Ile Cys Met 
    850                 855                 860                 


Ala Lys Thr His Leu Ser Leu Ser His Asn Pro Glu Gln Lys Gly Val 
865                 870                 875                 880 


Pro Thr Gly Phe Ile Leu Pro Ile Arg Asp Ile Arg Ala Ser Val Gly 
                885                 890                 895     


Ala Gly Phe Leu Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly 
            900                 905                 910         


Leu Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Pro Glu Thr 
        915                 920                 925             


Glu Gln Val Asn Gly Leu Phe 
    930                 935 


<210>  232
<211>  2879
<212>  DNA
<213>  Homo sapiens

<400>  232
catctctccc gccctctcca gagtcgactg aagtttccga ggagacttct caggctgggc       60

tggacacacc tttccaagga cccccaaact ctgctccgtg cacgtcaaat gctcctttcc      120

cttgtgtcca accccctacc cctctcccta acacccctct tctcaacaag actcagcctc      180

tccccgaggt gggtgagcat ccttgaggtt tcccaccctt aactgctgtg tccccggatg      240

gagccagaga aatgtggtgg gggggccggg gccagagttt caacattgcc ccccagaagg      300

aggagccaga gatggggtct gtccaggaaa ataggatgcc ggagcccagg agtcgtcagc      360

ctagcagttg cctggcctcc agatgcctcc caggggagca gatcctagca tgggccccag      420

gggtgaggaa gggcctggaa ccagaattgt ctggaaccct gatctgtacc aactttaggg      480

tcaccttcca gccctgtgga tggcagtgga atcaggacac tcccttgaac agtgaatacg      540

attttgccct ggtcaacatt ggacgattag aggctgtgag cggcttgtcc cgagtccagc      600

tcctccgtcc agggtccctg cataaattta tccctgagga gattctgatt catggccgag      660

acttccggct gctcagagtt ggttttgagg ctggaggcct agagcctcag gcttttcagg      720

tgaccatggc cattgtccaa gccagagctc agagcaatca agcccaacag tattcgggga      780

taaccctgag caaggctggc cagggttctg gctccagaaa accaccaatt cctctcatgg      840

agacagcgga agactgggag actgagcgga agaagcaggc agccagaggc tggagggtca      900

gcacggtcaa cgagaggttc gacgtagcca ccagcctccc ccgttacttc tgggtcccta      960

accgaattct ggacagtgag gtcaggagag catttggcca ctttcatcag ggccgtggac     1020

cgcgcttgtc ctggcatcac cctgggggca gtgatcttct ccgctgtgga ggcttctata     1080

cagccagtga ccctaacaag gaggatatca gagcagtgga gttgatgctc caggctgggc     1140

attcagatgt tgtcctggta gacactatgg atgagctgcc cagccttgca gatgtccaac     1200

ttgcccacct gaggctgagg gccctctgcc tgcctgattc atctgtagct gaggataaat     1260

ggctttcagc cctggaagga acacgatggc tggactatgt cagggcttgt cttcgaaagg     1320

ccagtgacat ttcagtatta gtgacatcca gggttcgttc tgtaatactt caagagcgcg     1380

gtgatcgtga tctcaatggc ctcctctctt cactcgtcca gctgctttca gcccccgaag     1440

cccgaacact gtttggcttc caatcactag tacagcgaga gtgggtggca gctggacatc     1500

ccttcctgac tcggcttggg ggaactgggg ccagtgaaga ggctccggtg tttctcctct     1560

tccttgattg tgtctggcag ctcctccagc agtttccagc tgattttgaa ttctctgagt     1620

ttttccttct tgctcttcat gacagtgtca gggttcctga cacccttacc ttcctgagaa     1680

ataccccctg ggagcgcgga aagcagagcg gacagttaaa ctcctataca caagtctaca     1740

ccccaggata ctcccagcct ccagctggga actcttttaa cctgcagctg tctgtctggg     1800

actgggattt acgttatagc aatgcacaga tactacaatt ccagaatcct ggctatgacc     1860

cagaacactg tccagattcc tggctcccta gaccacagcc aagcttcatg gttcctggac     1920

cccccagttc tgtgtggctc ttctctagag gagcattgac ccccctgaat cagctctgtc     1980

cttggcggga cagtccttcc ctgctggcag tctcttctcg ttggctccct cgacctgcta     2040

tctcctctga aagcctggct gaccaggaat ggggtctccc ctcacattgg ggagcttgcc     2100

ctttacctcc agggctgctg ctgcctgggt atctgggacc ccagatcagg ctctggagac     2160

gctgctacct gaggggaagg cctgaggtcc agatgggcct ctcagctccc acaatctctg     2220

gcctccagga tgagctatcc catcttcagg agttattacg gaaatggaca ccaagaatat     2280

ctcctgagga tcactccaag aaaagagatc cacataccat tctcaatccc actgaaattg     2340

ctggcattct caaaggcagg gcagaggggg atctggggta gaggagggtt ctgtctaatc     2400

tttttttttt ttttttgtat ctgcacttgc agcctcagct ttcacacttc agcccttaag     2460

ttcactaaga aggtctgagt ttctgctgca gatagtggtg ttaactgctc caactcttgt     2520

cttgcttagt ttctacaaat atttttgctt cttgtcattt gaaggattaa gaaacaaaaa     2580

caatccagaa attgatcggt ttttttaggc caatcccatc ccttctggat aaccagatgt     2640

taaatcatga gatcagagat gctgttcatc agtcccaaca agatggccta gaaatcgcat     2700

tctcacctcg ccttgctgct gctttaattc caagttctat ttcttccctt atagttttct     2760

atgggaatga ggcggataca ggaaacaccc tatctcctct gtatttttgt agtggaattt     2820

ctatttaagg ggctcattaa agcatagtat ttatacacaa aaaaaaaaaa aaaaaaaaa      2879


<210>  233
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Trp Trp Gly Gly Arg Gly Gln Ser Phe Asn Ile Ala Pro Gln Lys 
1               5                   10                  15      


Glu Glu Pro Glu Met Gly Ser Val Gln Glu Asn Arg Met Pro Glu Pro 
            20                  25                  30          


Arg Ser Arg Gln Pro Ser Ser Cys Leu Ala Ser Arg Cys Leu Pro Gly 
        35                  40                  45              


Glu Gln Ile Leu Ala Trp Ala Pro Gly Val Arg Lys Gly Leu Glu Pro 
    50                  55                  60                  


Glu Leu Ser Gly Thr Leu Ile Cys Thr Asn Phe Arg Val Thr Phe Gln 
65                  70                  75                  80  


Pro Cys Gly Trp Gln Trp Asn Gln Asp Thr Pro Leu Asn Ser Glu Tyr 
                85                  90                  95      


Asp Phe Ala Leu Val Asn Ile Gly Arg Leu Glu Ala Val Ser Gly Leu 
            100                 105                 110         


Ser Arg Val Gln Leu Leu Arg Pro Gly Ser Leu His Lys Phe Ile Pro 
        115                 120                 125             


Glu Glu Ile Leu Ile His Gly Arg Asp Phe Arg Leu Leu Arg Val Gly 
    130                 135                 140                 


Phe Glu Ala Gly Gly Leu Glu Pro Gln Ala Phe Gln Val Thr Met Ala 
145                 150                 155                 160 


Ile Val Gln Ala Arg Ala Gln Ser Asn Gln Ala Gln Gln Tyr Ser Gly 
                165                 170                 175     


Ile Thr Leu Ser Lys Ala Gly Gln Gly Ser Gly Ser Arg Lys Pro Pro 
            180                 185                 190         


Ile Pro Leu Met Glu Thr Ala Glu Asp Trp Glu Thr Glu Arg Lys Lys 
        195                 200                 205             


Gln Ala Ala Arg Gly Trp Arg Val Ser Thr Val Asn Glu Arg Phe Asp 
    210                 215                 220                 


Val Ala Thr Ser Leu Pro Arg Tyr Phe Trp Val Pro Asn Arg Ile Leu 
225                 230                 235                 240 


Asp Ser Glu Val Arg Arg Ala Phe Gly His Phe His Gln Gly Arg Gly 
                245                 250                 255     


Pro Arg Leu Ser Trp His His Pro Gly Gly Ser Asp Leu Leu Arg Cys 
            260                 265                 270         


Gly Gly Phe Tyr Thr Ala Ser Asp Pro Asn Lys Glu Asp Ile Arg Ala 
        275                 280                 285             


Val Glu Leu Met Leu Gln Ala Gly His Ser Asp Val Val Leu Val Asp 
    290                 295                 300                 


Thr Met Asp Glu Leu Pro Ser Leu Ala Asp Val Gln Leu Ala His Leu 
305                 310                 315                 320 


Arg Leu Arg Ala Leu Cys Leu Pro Asp Ser Ser Val Ala Glu Asp Lys 
                325                 330                 335     


Trp Leu Ser Ala Leu Glu Gly Thr Arg Trp Leu Asp Tyr Val Arg Ala 
            340                 345                 350         


Cys Leu Arg Lys Ala Ser Asp Ile Ser Val Leu Val Thr Ser Arg Val 
        355                 360                 365             


Arg Ser Val Ile Leu Gln Glu Arg Gly Asp Arg Asp Leu Asn Gly Leu 
    370                 375                 380                 


Leu Ser Ser Leu Val Gln Leu Leu Ser Ala Pro Glu Ala Arg Thr Leu 
385                 390                 395                 400 


Phe Gly Phe Gln Ser Leu Val Gln Arg Glu Trp Val Ala Ala Gly His 
                405                 410                 415     


Pro Phe Leu Thr Arg Leu Gly Gly Thr Gly Ala Ser Glu Glu Ala Pro 
            420                 425                 430         


Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Leu Gln Gln Phe 
        435                 440                 445             


Pro Ala Asp Phe Glu Phe Ser Glu Phe Phe Leu Leu Ala Leu His Asp 
    450                 455                 460                 


Ser Val Arg Val Pro Asp Thr Leu Thr Phe Leu Arg Asn Thr Pro Trp 
465                 470                 475                 480 


Glu Arg Gly Lys Gln Ser Gly Gln Leu Asn Ser Tyr Thr Gln Val Tyr 
                485                 490                 495     


Thr Pro Gly Tyr Ser Gln Pro Pro Ala Gly Asn Ser Phe Asn Leu Gln 
            500                 505                 510         


Leu Ser Val Trp Asp Trp Asp Leu Arg Tyr Ser Asn Ala Gln Ile Leu 
        515                 520                 525             


Gln Phe Gln Asn Pro Gly Tyr Asp Pro Glu His Cys Pro Asp Ser Trp 
    530                 535                 540                 


Leu Pro Arg Pro Gln Pro Ser Phe Met Val Pro Gly Pro Pro Ser Ser 
545                 550                 555                 560 


Val Trp Leu Phe Ser Arg Gly Ala Leu Thr Pro Leu Asn Gln Leu Cys 
                565                 570                 575     


Pro Trp Arg Asp Ser Pro Ser Leu Leu Ala Val Ser Ser Arg Trp Leu 
            580                 585                 590         


Pro Arg Pro Ala Ile Ser Ser Glu Ser Leu Ala Asp Gln Glu Trp Gly 
        595                 600                 605             


Leu Pro Ser His Trp Gly Ala Cys Pro Leu Pro Pro Gly Leu Leu Leu 
    610                 615                 620                 


Pro Gly Tyr Leu Gly Pro Gln Ile Arg Leu Trp Arg Arg Cys Tyr Leu 
625                 630                 635                 640 


Arg Gly Arg Pro Glu Val Gln Met Gly Leu Ser Ala Pro Thr Ile Ser 
                645                 650                 655     


Gly Leu Gln Asp Glu Leu Ser His Leu Gln Glu Leu Leu Arg Lys Trp 
            660                 665                 670         


Thr Pro Arg Ile Ser Pro Glu Asp His Ser Lys Lys Arg Asp Pro His 
        675                 680                 685             


Thr Ile Leu Asn Pro Thr Glu Ile Ala Gly Ile Leu Lys Gly Arg Ala 
    690                 695                 700                 


Glu Gly Asp Leu Gly 
705                 


<210>  234
<211>  2368
<212>  DNA
<213>  Homo sapiens

<400>  234
ccctgttagg tctggagctc cccacagaca ctgatctcag tttcccccga gagtgtgagt       60

gtaggcctct acaggcagct gcctctgggg agttggggag cctaggggtt aactctagac      120

ccccctcaac cctctggacc aaagtctgtc caggaaaata ggatgccgga gcccaggagt      180

cgtcagccta gcagttgcct ggcctccaga tgcctcccag ggtcaccttc cagccctgtg      240

gatggcagtg gaatcaggac actcccttga acagtgaata cgattttgcc ctggtcaaca      300

ttggacgatt agaggctgtg agcggcttgt cccgagtcca gctcctccgt ccagggtccc      360

tgcataaatt tatccctgag gagattctga ttcatggccg agacttccgg ctgctcagag      420

ttggttttga ggctggaggc ctagagcctc aggcttttca ggtgaccatg gccattgtcc      480

aagccagagc tcagagcaat caagcccaac agtattcggg gataaccctg agcaaggctg      540

gccagggttc tggctccaga aaaccaccaa ttcctctcat ggagacagcg gaagactggg      600

agactgagcg gaagaagcag gcagccagag gctggagggt cagcacggtc aacgagaggt      660

tcgacgtagc caccagcctc ccccgttact tctgggtccc taaccgaatt ctggacagtg      720

aggtcaggag agcatttggc cactttcatc agggccgtgg accgcgcttg tcctggcatc      780

accctggggg cagtgatctt ctccgctgtg gaggcttcta tacagccagt gaccctaaca      840

aggaggatat cagagcagtg gagttgatgc tccaggctgg gcattcagat gttgtcctgg      900

tagacactat ggatgagctg cccagccttg cagatgtcca acttgcccac ctgaggctga      960

gggccctctg cctgcctgat tcatctgtag ctgaggataa atggctttca gccctggaag     1020

gaacacgatg gctggactat gtcagggctt gtcttcgaaa ggccagtgac atttcagtat     1080

tagtgacatc cagggttcgt tctgtaatac ttcaagagcg cggtgatcgt gatctcaatg     1140

gcctcctctc ttcactcgtc cagctgcttt cagcccccga agcccgaaca ctgtttggct     1200

tccaatcact agtacagcga gagtgggtgg cagctggaca tcccttcctg actcggcttg     1260

ggggaactgg ggccagtgaa gaggctccgg tgtttctcct cttccttgat tgtgtctggc     1320

agctcctcca gcagtttcca gctgattttg aattctctga gtttttcctt cttgctcttc     1380

atgacagtgt cagggttcct gacaccctta ccttcctgag aaataccccc tgggagcgcg     1440

gaaagcagag cggacagtta aactcctata cacaagtcta caccccagga tactcccagc     1500

ctccagctgg gaactctttt aacctgcagc tgtctgtctg ggactgggat ttacgttata     1560

gcaatgcaca gatactacaa ttccagaatc ctggctatga cccagaacac tgtccagatt     1620

cctggctccc tagaccacag ccaagcttca tggttcctgg accccccagt tctgtgtggc     1680

tcttctctag aggagcattg acccccctga atcagctctg tccttggcgg gacagtcctt     1740

ccctgctggc agtctcttct cgttggctcc ctcgacctgc tatctcctct gaaagcctgg     1800

ctgaccagga atggggtctc ccctcacatt ggggagcttg ccctttacct ccagggctgc     1860

tgctgcctgg gtatctggga ccccagatca ggctctggag acgctgctac ctgaggggaa     1920

ggcctgaggt ccagatgggc ctctcagctc ccacaatctc tggcctccag gatgagctat     1980

cccatcttca ggagttatta cggaaatgga caccaagaat atctcctgag gatcactcca     2040

agaaaagaga tccacatacc attctcaatc ccactgaaat tgctggcatt ctcaaaggcc     2100

aatcccatcc cttctggata accagatgtt aaatcatgag atcagagatg ctgttcatca     2160

gtcccaacaa gatggcctag aaatcgcatt ctcacctcgc cttgctgctg ctttaattcc     2220

aagttctatt tcttccctta tagttttcta tgggaatgag gcggatacag gaaacaccct     2280

atctcctctg tatttttgta gtggaatttc tatttaaggg gctcattaaa gcatagtatt     2340

tatacacaaa aaaaaaaaaa aaaaaaaa                                        2368


<210>  235
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Pro Pro Arg Val Thr Phe Gln Pro Cys Gly Trp Gln Trp Asn Gln 
1               5                   10                  15      


Asp Thr Pro Leu Asn Ser Glu Tyr Asp Phe Ala Leu Val Asn Ile Gly 
            20                  25                  30          


Arg Leu Glu Ala Val Ser Gly Leu Ser Arg Val Gln Leu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu His Lys Phe Ile Pro Glu Glu Ile Leu Ile His Gly Arg 
    50                  55                  60                  


Asp Phe Arg Leu Leu Arg Val Gly Phe Glu Ala Gly Gly Leu Glu Pro 
65                  70                  75                  80  


Gln Ala Phe Gln Val Thr Met Ala Ile Val Gln Ala Arg Ala Gln Ser 
                85                  90                  95      


Asn Gln Ala Gln Gln Tyr Ser Gly Ile Thr Leu Ser Lys Ala Gly Gln 
            100                 105                 110         


Gly Ser Gly Ser Arg Lys Pro Pro Ile Pro Leu Met Glu Thr Ala Glu 
        115                 120                 125             


Asp Trp Glu Thr Glu Arg Lys Lys Gln Ala Ala Arg Gly Trp Arg Val 
    130                 135                 140                 


Ser Thr Val Asn Glu Arg Phe Asp Val Ala Thr Ser Leu Pro Arg Tyr 
145                 150                 155                 160 


Phe Trp Val Pro Asn Arg Ile Leu Asp Ser Glu Val Arg Arg Ala Phe 
                165                 170                 175     


Gly His Phe His Gln Gly Arg Gly Pro Arg Leu Ser Trp His His Pro 
            180                 185                 190         


Gly Gly Ser Asp Leu Leu Arg Cys Gly Gly Phe Tyr Thr Ala Ser Asp 
        195                 200                 205             


Pro Asn Lys Glu Asp Ile Arg Ala Val Glu Leu Met Leu Gln Ala Gly 
    210                 215                 220                 


His Ser Asp Val Val Leu Val Asp Thr Met Asp Glu Leu Pro Ser Leu 
225                 230                 235                 240 


Ala Asp Val Gln Leu Ala His Leu Arg Leu Arg Ala Leu Cys Leu Pro 
                245                 250                 255     


Asp Ser Ser Val Ala Glu Asp Lys Trp Leu Ser Ala Leu Glu Gly Thr 
            260                 265                 270         


Arg Trp Leu Asp Tyr Val Arg Ala Cys Leu Arg Lys Ala Ser Asp Ile 
        275                 280                 285             


Ser Val Leu Val Thr Ser Arg Val Arg Ser Val Ile Leu Gln Glu Arg 
    290                 295                 300                 


Gly Asp Arg Asp Leu Asn Gly Leu Leu Ser Ser Leu Val Gln Leu Leu 
305                 310                 315                 320 


Ser Ala Pro Glu Ala Arg Thr Leu Phe Gly Phe Gln Ser Leu Val Gln 
                325                 330                 335     


Arg Glu Trp Val Ala Ala Gly His Pro Phe Leu Thr Arg Leu Gly Gly 
            340                 345                 350         


Thr Gly Ala Ser Glu Glu Ala Pro Val Phe Leu Leu Phe Leu Asp Cys 
        355                 360                 365             


Val Trp Gln Leu Leu Gln Gln Phe Pro Ala Asp Phe Glu Phe Ser Glu 
    370                 375                 380                 


Phe Phe Leu Leu Ala Leu His Asp Ser Val Arg Val Pro Asp Thr Leu 
385                 390                 395                 400 


Thr Phe Leu Arg Asn Thr Pro Trp Glu Arg Gly Lys Gln Ser Gly Gln 
                405                 410                 415     


Leu Asn Ser Tyr Thr Gln Val Tyr Thr Pro Gly Tyr Ser Gln Pro Pro 
            420                 425                 430         


Ala Gly Asn Ser Phe Asn Leu Gln Leu Ser Val Trp Asp Trp Asp Leu 
        435                 440                 445             


Arg Tyr Ser Asn Ala Gln Ile Leu Gln Phe Gln Asn Pro Gly Tyr Asp 
    450                 455                 460                 


Pro Glu His Cys Pro Asp Ser Trp Leu Pro Arg Pro Gln Pro Ser Phe 
465                 470                 475                 480 


Met Val Pro Gly Pro Pro Ser Ser Val Trp Leu Phe Ser Arg Gly Ala 
                485                 490                 495     


Leu Thr Pro Leu Asn Gln Leu Cys Pro Trp Arg Asp Ser Pro Ser Leu 
            500                 505                 510         


Leu Ala Val Ser Ser Arg Trp Leu Pro Arg Pro Ala Ile Ser Ser Glu 
        515                 520                 525             


Ser Leu Ala Asp Gln Glu Trp Gly Leu Pro Ser His Trp Gly Ala Cys 
    530                 535                 540                 


Pro Leu Pro Pro Gly Leu Leu Leu Pro Gly Tyr Leu Gly Pro Gln Ile 
545                 550                 555                 560 


Arg Leu Trp Arg Arg Cys Tyr Leu Arg Gly Arg Pro Glu Val Gln Met 
                565                 570                 575     


Gly Leu Ser Ala Pro Thr Ile Ser Gly Leu Gln Asp Glu Leu Ser His 
            580                 585                 590         


Leu Gln Glu Leu Leu Arg Lys Trp Thr Pro Arg Ile Ser Pro Glu Asp 
        595                 600                 605             


His Ser Lys Lys Arg Asp Pro His Thr Ile Leu Asn Pro Thr Glu Ile 
    610                 615                 620                 


Ala Gly Ile Leu Lys Gly Gln Ser His Pro Phe Trp Ile Thr Arg Cys 
625                 630                 635                 640 


<210>  236
<211>  2379
<212>  DNA
<213>  Homo sapiens

<400>  236
gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc       60

ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag      120

ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc      180

cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag      240

agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg      300

gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa      360

ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac      420

gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc      480

caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg      540

gtagtggaaa accagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg      600

aactatgacc tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac      660

ttctaccagc agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg      720

aagaaattcg agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc      780

tcgccctcct acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc      840

gggagcttct ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg      900

gtgaaccaga gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc      960

caggactgta tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc     1020

tcctaccagg ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc     1080

tgctccacct ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac     1140

ccctcggtgg tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg     1200

caagactcca gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc     1260

ccgcagggca gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc     1320

gactctgagg aggaacaaga agatgaggaa gaaatcgatg ttgtttctgt ggaaaagagg     1380

caggctcctg gcaaaaggtc agagtctgga tcaccttctg ctggaggcca cagcaaacct     1440

cctcacagcc cactggtcct caagaggtgc cacgtctcca cacatcagca caactacgca     1500

gcgcctccct ccactcggaa ggactatcct gctgccaaga gggtcaagtt ggacagtgtc     1560

agagtcctga gacagatcag caacaaccga aaatgcacca gccccaggtc ctcggacacc     1620

gaggagaatg tcaagaggcg aacacacaac gtcttggagc gccagaggag gaacgagcta     1680

aaacggagct tttttgccct gcgtgaccag atcccggagt tggaaaacaa tgaaaaggcc     1740

cccaaggtag ttatccttaa aaaagccaca gcatacatcc tgtccgtcca agcagaggag     1800

caaaagctca tttctgaaga ggacttgttg cggaaacgac gagaacagtt gaaacacaaa     1860

cttgaacagc tacggaactc ttgtgcgtaa ggaaaagtaa ggaaaacgat tccttctaac     1920

agaaatgtcc tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc     1980

acaaccttgg ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt     2040

ggactttggg cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat     2100

ttgtatttaa gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata     2160

ttgccattaa atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat     2220

cctagtatat agtacctagt attataggta ctataaaccc taattttttt tatttaagta     2280

cattttgctt tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc     2340

aaatatatca ttgagccaaa tcttaaaaaa aaaaaaaaa                            2379


<210>  237
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  238
<211>  1117
<212>  DNA
<213>  Homo sapiens

<400>  238
atgcgttgct gggttatttt aatcattcta ggcatcgttt tcctccttat gcctctatca       60

ttcctcccta tctacactaa catcccacgc tctgaacgcg cgcccattaa tacccttctt      120

tcctccactc tccctgggac tcttgatcaa agcgcggccc tttccccagc cttagcgagg      180

cgccctgcag cctggtacgc gcgtggcgtg gcggtgggcg cgcagtgcgt tctcggtgtg      240

gagggcagct gttccgcctg cgatgattta tactcacagg acaaggatgc ggtttgtcaa      300

acagtactgc tacggaggag cagcagagaa agggagaggg tttgagaggg agcaaaagaa      360

aatggtaggc gcgcgtagtt aattcatgcg gctctcttac tctgtttaca tcctagagct      420

agagtgctcg gctgcccggc tgagtctcct ccccaccttc cccaccctcc ccaccctccc      480

cataagcgcc cctcccgggt tcccaaagca gagggcgtgg gggaaaagaa aaaagatcct      540

ctctcgctaa tctccgccca ccggcccttt ataatgcgag ggtctggacg gctgaggacc      600

cccgagctgt gctgctcgcg gccgccaccg ccgggccccg gccgtccctg gctcccctcc      660

tgcctcgaga agggcagggc ttctcagagg cttggcggga aaaagaacgg agggagggat      720

cgcgctgagt ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc      780

gagaggcaga gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct      840

gcgctgcggg cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc      900

agccctcccg ctgatccccc agccagcggt ccgcaaccct tgccgcatcc acgaaacttt      960

gcccatagca gcgggcgggc actttgcact ggaacttaca acacccgagc aaggacgcga     1020

ctctcccgac gcggggaggc tattctgccc atttggggac acttccccgc cgctgccagg     1080

acccgcttct ctgaaaggct ctccttgcag ctgctta                              1117


<210>  239
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Arg Cys Trp Val Ile Leu Ile Ile Leu Gly Ile Val Phe Leu Leu 
1               5                   10                  15      


Met Pro Leu Ser Phe Leu Pro Ile Tyr Thr Asn Ile Pro Arg Ser Glu 
            20                  25                  30          


Arg Ala Pro Ile Asn Thr Leu Leu Ser Ser Thr Leu Pro Gly Thr Leu 
        35                  40                  45              


Asp Gln Ser Ala Ala Leu Ser Pro Ala Leu Ala Arg Arg Pro Ala Ala 
    50                  55                  60                  


Trp Tyr Ala Arg Gly Val Ala Val Gly Ala Gln Cys Val Leu Gly Val 
65                  70                  75                  80  


Glu Gly Ser Cys Ser Ala Cys Asp Asp Leu Tyr Ser Gln Asp Lys Asp 
                85                  90                  95      


Ala Val Cys Gln Thr Val Leu Leu Arg Arg Ser Ser Arg Glu Arg Glu 
            100                 105                 110         


Arg Val 
        


<210>  240
<211>  1117
<212>  DNA
<213>  Homo sapiens

<400>  240
atgcgttgct gggttatttt aatcattcta ggcatcgttt tcctccttat gcctctatca       60

ttcctcccta tctacactaa catcccacgc tctgaacgcg cgcccattaa tacccttctt      120

tcctccactc tccctgggac tcttgatcaa agcgcggccc tttccccagc cttagcgagg      180

cgccctgcag cctggtacgc gcgtggcgtg gcggtgggcg cgcagtgcgt tctcggtgtg      240

gagggcagct gttccgcctg cgatgattta tactcacagg acaaggatgc ggtttgtcaa      300

acagtactgc tacggaggag cagcagagaa agggagaggg tttgagaggg agcaaaagaa      360

aatggtaggc gcgcgtagtt aattcatgcg gctctcttac tctgtttaca tcctagagct      420

agagtgctcg gctgcccggc tgagtctcct ccccaccttc cccaccctcc ccaccctccc      480

cataagcgcc cctcccgggt tcccaaagca gagggcgtgg gggaaaagaa aaaagatcct      540

ctctcgctaa tctccgccca ccggcccttt ataatgcgag ggtctggacg gctgaggacc      600

cccgagctgt gctgctcgcg gccgccaccg ccgggccccg gccgtccctg gctcccctcc      660

tgcctcgaga agggcagggc ttctcagagg cttggcggga aaaagaacgg agggagggat      720

cgcgctgagt ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc      780

gagaggcaga gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct      840

gcgctgcggg cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc      900

agccctcccg ctgatccccc agccagcggt ccgcaaccct tgccgcatcc acgaaacttt      960

gcccatagca gcgggcgggc actttgcact ggaacttaca acacccgagc aaggacgcga     1020

ctctcccgac gcggggaggc tattctgccc atttggggac acttccccgc cgctgccagg     1080

acccgcttct ctgaaaggct ctccttgcag ctgctta                              1117


<210>  241
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Arg Cys Trp Val Ile Leu Ile Ile Leu Gly Ile Val Phe Leu Leu 
1               5                   10                  15      


Met Pro Leu Ser Phe Leu Pro Ile Tyr Thr Asn Ile Pro Arg Ser Glu 
            20                  25                  30          


Arg Ala Pro Ile Asn Thr Leu Leu Ser Ser Thr Leu Pro Gly Thr Leu 
        35                  40                  45              


Asp Gln Ser Ala Ala Leu Ser Pro Ala Leu Ala Arg Arg Pro Ala Ala 
    50                  55                  60                  


Trp Tyr Ala Arg Gly Val Ala Val Gly Ala Gln Cys Val Leu Gly Val 
65                  70                  75                  80  


Glu Gly Ser Cys Ser Ala Cys Asp Asp Leu Tyr Ser Gln Asp Lys Asp 
                85                  90                  95      


Ala Val Cys Gln Thr Val Leu Leu Arg Arg Ser Ser Arg Glu Arg Glu 
            100                 105                 110         


Arg Val 
        


<210>  242
<211>  3576
<212>  DNA
<213>  Homo sapiens

<400>  242
gaaaggtcac agcgcggcag cgggtctggc tggcggcagc ggcgggaggg agccgagaga       60

cccgagtgca cgtgtggaga agcggcggca caagcgcggc ggcgggagac actcccgccc      120

ccaccagact caagccctca ctcgactctc gcggccttcg ttgctcgcac agctccctgc      180

ccaggctagg aggccggctt gcggggttga gtggcccgag ctaagggtgc ggagacctaa      240

gggcggcgac tacgacggcg ttgatatcgg tggtaacgac ggcctcagca ggcggggaag      300

atgaaaggta gccggatcga gctgggagat gtgacaccac acaatattaa acagttgaaa      360

agattgaatc aggtcatctt tccagtcagc tacaatgaca agttctacaa ggatgtgctg      420

gaggttggcg agctagcaaa acttgcctat ttcaatgata ttgctgtagg tgcagtatgc      480

tgtagggtgg atcattcaca gaatcagaag agactttaca tcatgacact aggatgtctg      540

gcaccttacc gaaggctagg aataggaact aaaatgttaa atcatgtctt aaacatctgt      600

gaaaaagatg gtacttttga caacatttat ctgcatgtcc agatcagcaa tgagtcggca      660

attgacttct acaggaagtt tggctttgag attattgaga caaagaagaa ctactataag      720

aggatagagc ccgcagatgc tcatgtgctg cagaaaaacc tcaaagttcc ttctggtcag      780

aatgcagatg tgcaaaagac agacaactga acaaattaca aatgaacttt cttgcacttg      840

cttgtcgcca aataaaagag aggcccattg attcctcccc caccccaaca cttttctttt      900

aaagcttttc tccctccttg ttcttgtttt tctttcttcc tttccttttc tctgagagtt      960

ttaatacttt caaggacttt aaaaaaataa tcatgtttga attgttttct cttatttttg     1020

tgaggtggtt tgaaggaagg acaaggtaga tctgtttagt tttgcagttg aagttagatg     1080

gtcctaaaca tttaattgtc aaataatttc aaatttaatg tcctgctttc acattgaagg     1140

gcagagccta caaaacattg tatatttcaa aagacaaaaa gaagcagcag cagtatcttg     1200

ttctctaatt catagacaag ttgagtgtgt ttgtggtact ttgggttttt aaacactttg     1260

ggatactaat ccctagacat tgccttcact ccacctttag tccttctgag cactctctcg     1320

ggagttggaa cattgttatc cttgtaagaa atactaagct tatgttgatt tttaagtaat     1380

tatatcttct cttcttgctg gtgggtgggg cagtttggtt tagtgttata ctttggtcta     1440

agtatttgag ttaaactgct tttttgctaa tgagtgggct ggttgttagc aggtttgttt     1500

ttcctgctgt tgattgttac tagtggcatt aacttttaga atttgggctg gtgagattaa     1560

ttttttttaa tatcccagct agagatatgg cctttaactg acctaaagag gtgtgttgtg     1620

atttaatttt ttcccgttcc tttttcttca gtaaacccaa caatagtcta accttaaaaa     1680

ttgagttgat gtccttatag gtcactaccc ctaaataaac ctgaagcagg tgttttctct     1740

tggacatact aaaaaatacc taaaaggaag cttagatggg ctgtgacaca aaaaattcaa     1800

ttactgtcat ctaatgccag ctgttaaaag tgtggccact gagcatttga ttttatagga     1860

aaaaatagta tttttgagaa taacatagct gtgctattgc acatctgttg gaggacatcc     1920

cagatttgct tatactcagt gcctgtgata ttgagtttaa ggatttgagg caggggtaat     1980

tattaaacat attgcttcta ttcttggaaa aatagaagtg taaaatgtta ataatacaaa     2040

tgtcactgtg acctcctcca ctgtgaggac tggtttatgc cagatcattt tccggcacac     2100

acggagtggc tttgacagat tgataacttt gtaagatggg agacatctga aatattcatg     2160

ttttcctttt gtagtcccat ctccactatt tagaaatgtt ctcagacttt aaaataatgc     2220

acagggcttg agctttctgt catttgactt taaaaggaag tttcattcat atttatcctc     2280

ttatgtaaaa ttgcggtata aagtctcatt tccaaatatg ttaaatgaca aaattatttt     2340

ataaaatgtt tatgcacact ttataacctt aagtttttat ttgagaatgt gaaagtacaa     2400

agtgcagtag acttcaacaa tcttgagtgc caagaataat acagaaaaag aagacagttg     2460

atgaatgagt ttatagggtt ctaatcttaa gatggtaaaa atgtagaaag accttgctgg     2520

ttttttgggg gtattcgttt cttaaacaat ccaaatctaa gcttagaaga aaagtttagc     2580

gttaagcacc tttatcttca tgaataagct tcagcttgct cttggcaaga gaagagtgct     2640

tgagttacag aaggcataag tagtttgaag aatgcagcag cctttttgta aacttcccag     2700

atatcaaaat agactttgat atataaatgg ttttctgaga tgacactgcc tctatttcta     2760

taaccatttc acctggacta tctaaccagt cctatgaatg tatccctaaa tgtggttatt     2820

gaaaacctaa tagctgcctc atgacaagta catgttattt aaggaggaaa aaatattaaa     2880

ttttgaattg agtgtgtagg ctccctatca ttatatatag agtttctttt tccacggtag     2940

tcagtgactt aacctgaatt gtaaatgttt gtaaagggtt aattgtccta catcaaactt     3000

agttaaataa ttccatccac ttatggagga ggaggagaat gtggaagagg taaaaagctg     3060

ggcacaagtt catatgccta tgagtcagta aagactgaag taatgtccta tgttgagctg     3120

gttattttga tatatgataa taattatctt tgaagtagaa caattctgtt aactggaaaa     3180

tcacaggata tatccatcat atttttcagg acagatagtt tttactgtgg ggcaaatagg     3240

ttaaaattac actatgttag ttgcatttag gttttaaagc aaagaatctg tagagaaatc     3300

tatgcaatat atagtttgtc cagattagct ttcatttggg gaatgaagtt ctgaaatatc     3360

taaagcagtt tactcatcaa ttgaaaagtc ctccaaaaag agaactattg ggaaaccatg     3420

gtgtggtggt ggaaaagaaa agctccctca gttttttgga gggaataact taaaaaaata     3480

cttaaatggc taagtttact tggtgcagtt aagaattaaa cttgtcaatt ttaacattgc     3540

tgttacatct gaaataaact tatgtgatgt tctggt                               3576


<210>  243
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Lys Gly Ser Arg Ile Glu Leu Gly Asp Val Thr Pro His Asn Ile 
1               5                   10                  15      


Lys Gln Leu Lys Arg Leu Asn Gln Val Ile Phe Pro Val Ser Tyr Asn 
            20                  25                  30          


Asp Lys Phe Tyr Lys Asp Val Leu Glu Val Gly Glu Leu Ala Lys Leu 
        35                  40                  45              


Ala Tyr Phe Asn Asp Ile Ala Val Gly Ala Val Cys Cys Arg Val Asp 
    50                  55                  60                  


His Ser Gln Asn Gln Lys Arg Leu Tyr Ile Met Thr Leu Gly Cys Leu 
65                  70                  75                  80  


Ala Pro Tyr Arg Arg Leu Gly Ile Gly Thr Lys Met Leu Asn His Val 
                85                  90                  95      


Leu Asn Ile Cys Glu Lys Asp Gly Thr Phe Asp Asn Ile Tyr Leu His 
            100                 105                 110         


Val Gln Ile Ser Asn Glu Ser Ala Ile Asp Phe Tyr Arg Lys Phe Gly 
        115                 120                 125             


Phe Glu Ile Ile Glu Thr Lys Lys Asn Tyr Tyr Lys Arg Ile Glu Pro 
    130                 135                 140                 


Ala Asp Ala His Val Leu Gln Lys Asn Leu Lys Val Pro Ser Gly Gln 
145                 150                 155                 160 


Asn Ala Asp Val Gln Lys Thr Asp Asn 
                165                 


<210>  244
<211>  9848
<212>  DNA
<213>  Homo sapiens

<400>  244
ctatgagtct ggcaggaagc tgaacagttt tacaaattag gcaatcaaga ctcaggattt       60

aagtgacttg gactgaactg gctcaatttc ttcaaatata gagagtacaa agaaacctgg      120

tcaatcttac tactgtcctt gaaagaatgt tttttcctaa ttcagcaagg caaaactgtt      180

agcaaaagtg ttcttcaaca agggatctgt gattgtatgt taaaaagctt tctctaaggt      240

acttatcact taagtaacaa tgacctgatt catttttgtt ttttgtgggg aattgtaaca      300

gtaaggaaat catggttctt cactgtttta gtgagatagg tgaattttgg aattgtgtac      360

caactgaggt aaggcaaaag tctacagtaa aactgttaga attctactta aaaatatgaa      420

tagaaaatgc agaaaatcag taaataaaaa taaatctaca gaccagttgc atgcagagtg      480

agtttgaatg tgtcatgtat gatgctgagt tactgatgtg actctgagca catgtgactc      540

tgtgggctca ccccatagga cttggtattc tctgctgggt tcacactatc tctaattagg      600

gaacatttaa gcttatgttt actgtgttag agaacatcga cttaaatcta ccctattaac      660

aaatagagtt tctcaggttg ttttgttgct ttgctctgcc gaagttcaat ttagaccatt      720

tctaattaaa ttaaacgtga atgagagaag actgttagaa gaggtaaaca ttctcagttc      780

ttccagaatt cttcctaaaa agtagctgaa ccaccctttc cctggggttt agcagagatt      840

gtgagttgcc tcatggaagg caggggccat gctttattga caatatttat ttccagaacc      900

tcaatgagga caaagcttat aaaaagcatt cagtacacac tggctgaata aaccaatgag      960

ctgcagtctg gaagccttcc cgggacagac tctctggact ttagtaaaat agagagcttc     1020

cttggaggtc cccacacact tatcttgaca gtgaccttat tggtttgtaa tgaattgttg     1080

atgtttcttt cccactagaa aattatctcc cagaagttat tttttgtcag ctgtgaatct     1140

ctataatctg tgaacacaca cacacacaca cacacacaca cacacacaca catattaatt     1200

gaattgtaga ggttttttat gtctagactt cttatactaa gagggtacca tagacagcat     1260

ataggcatga aacaattaac tcaaaagcaa aaattttatt aagacagaac tgagacgagg     1320

gttccagtat cttgagagtc tcccctggcc agtgtttctt gtctccttca cctatgcacc     1380

catctgacaa tttaaaaaac taaagcttgg agattcatgt tggcaatttt ttattattag     1440

tgtacgtggt atatatagct tttccgcaat ttggttggag aaatgttttg ctagcttccc     1500

agaaactagc agccttcacc aaagtggggg ctgtcttaag gtgtgccccc ttaccttggg     1560

ataaagctat gtgctatgga atcacacaag cccgtgtttg tatttttttc attttaattt     1620

ttaaacactt gcataaaatt aaggggtaaa gtgcagtttg gcttcatgga tctattgctt     1680

taggggaagt ctgggctttt agagtgacca tcacttgcat aatgtacatt gtacccatta     1740

agtaatttct catccctcaa ccccttccaa cctccaaccc ttcttagtct ctagtgtgat     1800

tgttccacac tctacatcca cattatttag ctctccctta tttagctccc ctgtatacat     1860

tatttagctc ccccttatga atgagaacat gcagtgttgg attttcagaa agcctttctg     1920

agccttggtt ttctcatctg tgtaagtggg atttgaatgc cttcctgagg gactctcaac     1980

cctagcttaa cccctctcct ctcctccctc cctgcactaa tgcctgtggc tctcttctgt     2040

ctgctagggt gggatcgaaa gttaaaaata tcagcatatt tcaaccttat ttcagttttc     2100

ttgacattgt tttagaaact tgagtgttac tcctcccttt accacagcta ggttatcgtg     2160

ttctttcaca gtgcttttag tgtttttttt cctatgtcat tatgttctgt gttagtctgc     2220

cccgcaagac tctaagcttt atgatgatta gagactttgt ctgctttatt tatgcatgcc     2280

taacaatcag ttttgaatct tgcacaaatg ttgagtgcac ggttaatgag ggaatatgta     2340

gtgtttgggt taaaaggcat gagctccaca gcaagcctga gcgtggagtc agtgagctga     2400

ggtgaatggg accatctcca gtttcaagat gatcttatcg ggatcaaact gatgtaaaaa     2460

atcttatttt gtactacaat aaaagtttaa aactgaaaaa aaatcatgta attgaaatta     2520

aatgagcttt ttttgttttc tgtggttcat aacaaaatac ttgaaactgg gcagtttata     2580

aagaaaagga atttatttct tacagttatg gaggttgaaa agtccaaggt tgaagggact     2640

tcttgctggt agggactctc tgtagagtcc cgaggtgaca cagggcatca cacggtgagg     2700

ggctgagcat gttagcttag ttctctcttc ctcttcttat gaagccactg gtcccatgcc     2760

attaaaaccc attaaaccat taacccagga attaagtttc aacatgagtt ttggaggcga     2820

caaatattca aatcatagca ttgatttgaa tatttgtagg gctctacaac aaggccactg     2880

tgtcacccag gttagtaacc aataaaacat acatttttca ttagtgtctc tcagttgctg     2940

aagtatgagg accctgactg atagctttca tctgtattat tggtggtcgg gatgatatta     3000

ttttatatgt cctaaacagc accaaatata aagatctcta taatgtcctt aaattttttt     3060

tttaatttag cttttaaagt tatttgaggt ttgtagattt tgctgtttat ctcacaaaat     3120

aactctgttt cagttactct gtcttggact tactattttc accagttgaa atgtgttgta     3180

ggaatactgg atggaattca gcatatgtaa gttctaggcc catttttctt ttttagcaaa     3240

taagctttgc cattatagtt acatttacat tacttatgcc ctgaaggcct aagtcttatt     3300

tgtgtagtga ataggaacac acacacacac agacacacag acacacacac atttatcaaa     3360

atttgataat atgtaattaa tttagtatta tcaacttggg aattactgaa ttcttttgct     3420

gtgcataaag attattgaag agcagcatct actcccttag aattttcaca tctagtattc     3480

tttctttata ttgttaaaat aattttaata atgatctaaa ttggatataa attcaggtaa     3540

ttattgccat cattttgtat aagtactgtc gtatctggta ctagttgtct ctgacagcaa     3600

aataaaacat gatgatcaat attttggatt gatttttttc tgctgggacg atgtgagcat     3660

acactgatta gagctgattt ttgctgctga tcagtctcta tgaggcaaaa tttcaataat     3720

tgttttgttt ttaggtgact ttcttctctg atgtccagac tgatttgcag attgcaaaga     3780

tccactctta taatagaaag agatgccatt agattagaaa aaaagccact tatcacagga     3840

attacgtgct aacacagtgg ttcaccttaa tgttctctct ttataatgcc ccctttcaag     3900

atgtgcataa ttgatattgc cataagcact ctcctattct ttttgcacag ctaaaagaat     3960

agagtggatt agaatacaga gtaaagtctc aggattgcac aacagaatta atcctgttct     4020

atgtcataaa atattgcatt cattagaaat gaatattttc attgcaaatg aactgagacc     4080

ggcaggtaga cggagtgatt ccttttattt tgtttctctt agaaggaatg attccaacaa     4140

atggtaaaaa tacaactaag gtttggcatg tgccaatcac ctatttcaca atgtattttt     4200

tagaggaaaa cacacacaca cacacacaca cacacacaca catatatgta tatcacaaag     4260

taaccctttt ctcttgtggc agtatctcct taggtcccat tcatttttag aacccacatg     4320

tattcttagc accctgtgat acttgctacc agagtgaaca tattttccca gccacaacct     4380

gattgcatgt tctggattat actcatattc tccagaaata atttaaggat tgagttcaat     4440

aatcgtgctc ccgaggtggg tgccatctga aatctaaccc ataatgttta cctgcggtga     4500

tgatcaagaa cctctcttga gagaattagg cccttaggga tattttagag caacgtttag     4560

attttttaaa taacaaaaat catgatcaag aacatctgtt gaaagaatta ggcctttatg     4620

gatattttag agcaatgttt agatttttta aataacaaaa atgctaatga gaatgatgat     4680

ggattctgct tgttgagtgc tttttgtctt cataaatttc catgagaaag gtgttaatgt     4740

gtccatttta tgaattagtc atctgacact cagaacacct aaataacttg ctggaggtca     4800

cacagctggg tgagcgacgg agccagaatt tgacctcagc actgcctgat tatgaagctg     4860

tgtgttctgt ctgctttcag ctgctgcctc ttatttccag ttccaaggtc agtctaaaac     4920

agtcctccca aacacccaca tatgttgaat ccttatgctg aaggcaggtg gtgccatggg     4980

cttttcaggg tgagtggttt atttttcaag aagcacagag aattaattca ttaagtggaa     5040

cttgagaggc tactcaaata tctgagctgc tgagaagttc aaccttttta attatctgga     5100

gtgagacttc ccacaatgtt aaaccttcag aatggtgcca gactcagaag ctcctctgca     5160

gtgattctga attgacagaa tacagtcaaa tagccaagat gaagtcaaga tctgaacatt     5220

ccaaccagcg tgttgcaatg gttctgccac acaggaaaaa ggaaaggcgg gcttttgttg     5280

ctagtgaagg gataatgacc aattaaaaaa ataaaactga gcaaagagag acaaagaagg     5340

aaatgagaca gggaaagaga gaacatagag atgagcataa aaattgcaga gaaagtgagt     5400

aaatgtagtg tcagaaaaga taaaaaaagg tgaaatattt tgtgtaaggg atgacaacag     5460

ggtgtcaagt gacagctatt ctaagagcac aaaagaaacc tgagactaaa gaaagaaatc     5520

atttttgtga ttaagagaag gattaggaaa caaaaaacaa tttaattatt acagataata     5580

ttgctaagta ttttcgttac acatatgaag tacttctgcg tgtgatattt catttaatcc     5640

cctcacaata ttcctgcgta attggttaag tggatatttc agactttatt tcagaaatat     5700

agaaacttag tgcttgattt gtctagtttc taaaataagt ggtagagttg aaacaagaaa     5760

atgtgtgttt tttttcacta ggtgctgcta gacatccttg tgtgatgtta aaagtacatc     5820

tgccataaca tggctttacc acgtatgctt gggggcattt aattactggg ctagtctggt     5880

cttcttttga aataccccta ggggatagcg acatgtaaaa agtgcagcac tgagtgtatt     5940

tcaactattg cattttacta acctgagatt gtcagggtgc ttttattata aaatggagat     6000

caagtatgga aaaaaggtat tacttctgtt actaccgctt tggtggttat agaaggtgat     6060

gaactgaaac atcaggacct gtggattttg caacagagac aaggccaaac tggctcacct     6120

gcagaataaa caaagggtaa tgtctataaa gagaattgtg aataacggtg cttatctgtt     6180

gttcctgtct acccaggatc tcttttctca tcttcttggt tgtgaataca ttaggtgggg     6240

ttgactcatc tccccttctc tatccaacat agattggcat atgctttgca ctgggccagt     6300

gttctccttg gctactttct gccagagtac atggaaaaaa caggtattgc tcagttgtat     6360

agggatctgg ggttgccact taccatttta tccatgccat ggtgggagcc tgatggaaaa     6420

cccaggacag gtggagccct tggccccact gattgagcct ccagaaaata ggatcgcctg     6480

aatccttgga cttgccattt ggggtaacaa ataaatcctc aagctagtat aagttgagat     6540

ctggtcactg taaatcagtc aaatacaaat gcaggtagct ggtgcatcat aataataacc     6600

aacacttatt gaatgtatgc tatactagta agcattcttt aatcacttca ttctcgcagc     6660

aatcctatga cgtgcatgtc cattactgtc tccatttcac aggaagaaac agagacagac     6720

ttgttagatg acttgttaaa gatcagagat aggaagaagc agagctggga tttgaactca     6780

ggaagtctag ctgtactctg tgaactctag tcattctcta tctctctttg tgtatatccc     6840

cttgccatat atgtgtaaat gcctttatct ttctatatgt gtatctatat ctgtctgtat     6900

gttatctctc tgaaatatgc aaattattgg caagaattga atttatgtta caaattagaa     6960

cattaatgtt ggttctgtgc atggaaatta gtatctcaaa tttcatccca gtgtcatgga     7020

caagaataga aatttctatt agagcttaaa aagaaactat agatctatga gtgttttgaa     7080

aagagcacaa taggaaaatt aaaataagta taatattgaa gcatccatat tatatgacat     7140

taagtctcag taagagactg agttagctga tcaaatcttt tagcagtaaa aacaaaacaa     7200

aacagacaaa aaaacagagg caatcacgta taagcactag ggcatattta atatgactgt     7260

tattgaggag aagactgcag ttgggaagaa tctttgaaca gatacttact aaaaactaaa     7320

atattttgtg agtcagaaca tttagccaat ccagctacta agatatttca aagtcgaatg     7380

agttatcaca aagctagaag acaaaaaaca ctgtactggg gaagctgtct aatttagtta     7440

atccagttaa ctaacttagg cagttagtga gtctggtgcc aagctacatg tcgaatcgaa     7500

agggttaagt ttttcacctt gcatcactga tataaggtgc tcggaaaagt aaattttatt     7560

actaagaagt gtcaagctcc tatgtaactt ccttttgcaa gaaaaaaagc aagaaaagta     7620

ggtaaacact taaaaaaatc tgctcttatg cttttggaaa aaagaatttt ctaagaatcg     7680

tggttatgat ttaggacaga ggtaagcaaa tgggccaaat ctggcccacc acctgttctt     7740

gtaaggcctg tatacttgga acgattttta tgtttataaa tggttgataa aagttacaag     7800

aagaataata ttgttacttg tgaaaattat atgaaattta aattttaatg tccatacata     7860

agttttattg gaatatagcc acactaattt ccatattgcc tatgactgct tttgtgctat     7920

gccagcagag ttgagtaatt gtggtaaaga ttgtataacc tgcaaagcct aaaacatgta     7980

ctggtccttt acagaagcaa tttgccaacc ctctatttgg ataatagagc aatggtattg     8040

ggaggtactt gaaatgttgt aaggaagcag agttagtgcc tagaaacaaa caaagtgaca     8100

aataagtaag tatatgtggg taggttttaa acatccttcc tattgtcttg atattgtttc     8160

ctgaattaaa accgtaaacc aaaattgcat ccaaatatgc agtgcagttt tagaacctct     8220

tttttttttt gaatctttat tctatttatt accaatatga taagttatac aacctttctc     8280

agccttggtt ttctcaatgg aaaaattaca gaaataattc tcttttttgt gacaagttta     8340

cacaaccttc tttgggaggt gatgtagtgg gttatcaatt tcagcataac atagaacaca     8400

tgtatttaat aatagaatga cttcatgaac actgtgtcct gttgaaatat gtagtctcat     8460

aaagataaag cagggacata tttgggtttt ggaatgaggt tttcttaaaa tacccatgta     8520

aattctgaaa acgtagccat tcttggactt cattcacctc atcaatggac ttggaaaagg     8580

aagcaggatt caaaaaatga aggtcagcta gcaggaagat tatgatcccc attcaccatt     8640

gtactgcaat ctagaaattg cagttctggt gtggacatag gagaggcaaa gaaaagagtg     8700

ctaaaaaagg gccaagtaat tccatatttt ggagttgact gtcagattgt tgtgcttatg     8760

ctgtttgtct gtttataatt accaaccagc tttttttctt atctctacgt ttataaattc     8820

tacccatgta ttatatttat ttaaaaacat ttgaagcata taacgtatac aaaatgtata     8880

tctcactgtg caggctgaag aatgataatc aatttttcca tgtacccatc tttaatctct     8940

caaacactgt ttcctctgtg ttcttaggaa atactttttc tattttctat tctaattgct     9000

tgtgtatatg tgtcctaaat tcttctgaaa tactgtgagt ttcttcaatg catgattctt     9060

gactcattca tgtttggttc ccattacctt caacatgtaa ggatgtaaat aaatatgtgt     9120

agagtgagtg agtgaatgca ttgcaagctc tctgtggtga gaactcattt attatcttac     9180

tattcctttc agttactatg cttaggggca attaacaaat gttggaattg aatgcattga     9240

aaggtcctgt tagtctgtct aggcacctct tgaatgtttg tgcaaggcac tgtgctgtgt     9300

tatgtgttgt tcattcatgt tcatgaaagt aataaaatat aaaacttact gaggagtttg     9360

agactatcct gtctgttcat tgaagacctc atattgtcat attacttgca attgtaattg     9420

tcgtattctt tctttctctt tccagctatt tctggtagtc atgtcaagtt gagtttatat     9480

gctaggtttg atgaagaggc agcatggagt gtgattggaa aaatggagtg tgatctaatg     9540

gaaataaact ggggagaact tagcagggcc agttggttca gattctcctc tgtatcctgt     9600

ttcttcagag ataggatttt gctttcttct gggaatatgg aagccactct agaatgaggg     9660

tcttatgacc cacttcaagg gaaggtcaga aaaatccttc ctggatttta ggaccaaatt     9720

tgaggggaag gtgagaatga ccttcctgct tctgctatag tctccaatgt caaggtgcca     9780

tatttttggg ctaacatgtc ttaaacccca tcaaactgta ttatctaatc cttggtttcc     9840

tcatctgc                                                              9848


<210>  245
<211>  770
<212>  DNA
<213>  Homo sapiens

<400>  245
agtatgccgg cagccccgcc ctgtgtgcgg tgtctaagga ttccgtcccc aagcaaggac       60

aacatattat cttccccgcc cttctctttt ctacagtatc tgttacctca gtcagattga      120

ggatgcacat atactgggaa aataatcgac ttccagcgtc cctcatgtag tctctacctg      180

attcaggaat ctctaaccca gtatcggaac gttaagcggc ttctccgctt tcctgccgtg      240

agaaactcga ggtgacaacc tccgtttccg gttggctccg gttgcagagt tgagtgtcct      300

gagaggtcag attgctgtca gacatggccc atgaacatgg acatgagcat ggacatcata      360

aaatggaact tccagattat agacaatgga agatagaagg gacaccatta gaaactatcc      420

agaagaagct ggctgcaaaa gggctaaggg atccatgggg ccgcaatgaa gcttggagat      480

acatgggtgg ctttgcaaag agtgtttcct tttctgatgt attctttaaa ggattcaaat      540

ggggatttgc tgcatttgtg gtagctgtag gagctgaata ttacctggag tccctgaata      600

aagataagaa gcatcactga agataatacc tggaagcatc atagtggttt cttaactctc      660

caaaataaga tttcttctct gtagcctact tgtctggttt atcccttaca gaatattagt      720

aagatttaat caattaaaat atatatatat gccaaaaaaa aaaaaaaaaa                 770


<210>  246
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ala His Glu His Gly His Glu His Gly His His Lys Met Glu Leu 
1               5                   10                  15      


Pro Asp Tyr Arg Gln Trp Lys Ile Glu Gly Thr Pro Leu Glu Thr Ile 
            20                  25                  30          


Gln Lys Lys Leu Ala Ala Lys Gly Leu Arg Asp Pro Trp Gly Arg Asn 
        35                  40                  45              


Glu Ala Trp Arg Tyr Met Gly Gly Phe Ala Lys Ser Val Ser Phe Ser 
    50                  55                  60                  


Asp Val Phe Phe Lys Gly Phe Lys Trp Gly Phe Ala Ala Phe Val Val 
65                  70                  75                  80  


Ala Val Gly Ala Glu Tyr Tyr Leu Glu Ser Leu Asn Lys Asp Lys Lys 
                85                  90                  95      


His His 
        


<210>  247
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  247
gctgcaaacg tctcgctgag gtcatccttt acggcaggcg tccgcgtcgc tagctagtcg       60

ttctgaagcg gcggccagag aagagtcaag ggcacgagca tcgggtagcc atgcctttct      120

tggacatcca gaaaaggttc ggccttaaca tagatcgatg gttgacaatc cagagtggtg      180

aacagcccta caagatggct ggtcgatgcc atgcttttga aaaagaatgg atagaatgtg      240

cacatggaat cggttatact cgggcagaga aagagtgcaa gatagaatat gatgatttcg      300

tagagtgttt gcttcggcag aaaacgatga gacgtgcagg taccatcagg aagcagcggg      360

ataagctgat aaaggaagga aagtacaccc ctccacctca ccacattggc aagggggagc      420

ctcggccctg aacagagcag ctgctgatgt ctggaggctg attttcctgt tctctgttct      480

ccactggaaa ggttgtttac gacaaacctc cttgtcaaag tgtgtaaaaa taaaggattg      540

ctccatccta tttgttctat tttctcttgg aaaaaaaaaa aaaa                       584


<210>  248
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg 
1               5                   10                  15      


Trp Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg 
            20                  25                  30          


Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly 
        35                  40                  45              


Tyr Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val 
    50                  55                  60                  


Glu Cys Leu Leu Arg Gln Lys Thr Met Arg Arg Ala Gly Thr Ile Arg 
65                  70                  75                  80  


Lys Gln Arg Asp Lys Leu Ile Lys Glu Gly Lys Tyr Thr Pro Pro Pro 
                85                  90                  95      


His His Ile Gly Lys Gly Glu Pro Arg Pro 
            100                 105     


<210>  249
<211>  6236
<212>  DNA
<213>  Homo sapiens

<400>  249
cattttgcta ggcagcggca gtggcggcgg cagcggcggc tggagcctct gattgggttt       60

cggagtccgg tactggagcc aatcagcgcg ggcagcgaac cgggggagcg aggcacggag      120

tgtacctcac agccttctag gatctccaga gtggacagga atctcacttg gagggaccat      180

ggagcagtat acagcaaaca gcaatagttc gacagagcag attgttgtcc aggcaggaca      240

gattcagcag cagcagcagg gtggtgtcac tgctgtgcag ttgcagactg aggcccaggt      300

ggcatccgcc tcaggccagc aagtccagac cctccaggta gtccaagggc agccattaat      360

ggtgcaggtc agtggaggcc agctaatcac atcaactggc caacccatca tggtccaggc      420

tgtccctggt ggacaaggtc aaaccatcat gcaagtacct gtttctggaa cacagggttt      480

gcagcaaata cagttggtcc cacctggaca gatccagatc cagggtggac aggctgtgca      540

ggtgcagggc cagcagggcc agacccagca gatcatcatc cagcagcccc agacggctgt      600

cactgctggc cagactcaga cacagcagca gattgctgtc cagggacagc aagtggcaca      660

gactgctgaa gggcagacca tcgtctatca accagttaat gcagatggca ccattctcca      720

gcaagttaca gtccctgttt caggcatgat cactatccca gcagccagtt tggcaggagc      780

acagattgtt caaacaggag ccaataccaa cacaaccagc agtgggcaag ggactgtcac      840

tgtgacacta ccagtggcag gcaatgtggt caattcagga gggatggtca tgatggttcc      900

tggggctggc tctgtgcctg ctatccaaag aatccctcta cctggagcag agatgcttga      960

agaagagcct ctctacgtga atgccaaaca ataccaccgt attcttaaga ggaggcaagc     1020

ccgagctaaa ctagaggcag aagggaaaat tccaaaggag agaaggaaat acctgcatga     1080

gtctcggcac cgtcatgcca tggcacggaa gcgtggtgaa ggtggacgat ttttctctcc     1140

aaaggaaaag gatagtcccc atatgcagga tccaaaccaa gccgatgaag aagcaatgac     1200

acagatcatc cgagtgtcct aaccccacgc catgtgatgg agctgatcaa ggtcatgttt     1260

ctcactgttc caggaaattg atcaactctt ccaatgggac attgatgatc acattctgcc     1320

ctttactaca ggacagaaac cacttagttt ttaataagtg gctcagtatt acaattgcag     1380

cgatgcctgg caaattgaag ttgcaagcct ttgtcttact ctttcagtca ggacctattt     1440

cagactgttg atgacattga catttcatgg attcggatga tgcaaggaga cacatgccac     1500

cccagcagta cacaaagcac ttaccttgac tggtgaagtc agccagccat ctcagcaggg     1560

aagaacaacc ttctcaacca aaactgcaat caggaaagca gcagcccact ccttcccatg     1620

gaatctagac agcatttatc cctctggtgg gggaatctca cactgactaa ctgaatggac     1680

gctttgtatt cagagatggc ttccaggcaa ggaagttcta tcttgtgata cggaaacaat     1740

aaattcctga gatacattct tccaatctgt ggtaataata agaattcctc tctgcccaga     1800

tggtaggttg atatttctgg actctagcca agaaaaagct aattctgggg atagaatgat     1860

aaaagactca agcactaaaa atatacattg ccgaatctct ttttctagct ttgaaaagtt     1920

gtggcctgct tgtccctctg ttgactggtc atctggacca tcgtacttgc tgtggctact     1980

tctaagacaa tgtagagggt tattaaacct tgaaactgcc tttcctaagt agagaacaag     2040

actattcaac aacttctttg ctgaagcact gaggagattt gtaatactcc taaaggaagg     2100

gccaaactag agattttcaa tcatagactt tgtgacagca tttggggaac taaaagattc     2160

atgtgtttca gcctagtggg agagagtggg ggagaggaag agagagagag agcatgtata     2220

cccgtatgtt atcatagagc acgattctcc agtggatgga tacctggaat ggatcattaa     2280

gatgaagaga gtaattcaca tttactctag aacctttaac aagcactgaa aggaagaagc     2340

ctgagatttg atccttgaca atttctggaa agcactggtc agtcacactg tcctggacag     2400

agtccaagtt acccactaaa gcttgaggtg gatgttggct tcactcctgc agcacaatgc     2460

tggccctaga aagcgagcat tttcattctt cccatggcag ctgattcttt ggtgccagtt     2520

ttcatgtttt ctccataggc cttgtgcaga aaggttttct cattgcatcc atactgtgag     2580

aataaactgc agactgaaag aaacatgcct gcagggtcag gaactgggcc actgttccca     2640

gaacgggttg tgcctcagaa atctatttct cttttagatg ttgaaccctg agagaactaa     2700

gatgatattt cagaagagtt ggctgccttc tctggaaaca aggaaaaccc aataattccg     2760

aggaacattg ggggttaaat accaagaata aaaattggtt cttctttgac ttcagcttaa     2820

ctgtattaag acagaaatta agccctctaa aaacaccaca aagagagatg attgtaatga     2880

tagaaataga ggtacagagc tatgcaaagg aaacaggaag tgaaatattc ctagtcccag     2940

ggatctggta atcgctcctg gcttccagat gtcaaaggac tgatcctttg gtaagctcac     3000

tagaaacttc tagctctaca agagtttggg atattaatgt tattcagtaa gtcccaagtt     3060

tttcagagaa tagattacta acaatgagga atttatattc cttggttaat ttaggagtct     3120

aagatgcaga gttcagaaag aaattactca gacctaactt tgagtgctta agctgccaac     3180

agttagaaga tgctatttat ttgtgtctgt aagtttgtac atagtaatgc cagccttgtt     3240

gctgaatttt ttatttgggg ggagatgact ttgaattttg tttgaaatgc ttcagttgtc     3300

attttgtcat tgcatttcaa atagctcatg acccttttct tgtggtcact ttggcacacc     3360

atagtagccc acaaagtggg ggcagggtat tgacatttgg attttttctt tgatactagt     3420

tcttttattc atttttattt gtgactgtag tgataacttt acagatggag aaagagtgaa     3480

tggatgaatg aataattggt ttaatgccta gttatgcaac ttgagtgctt tttttttttt     3540

ttgcaggata attttaagtg tatatatttt aactgcactg gtacattgaa catgtcagtg     3600

tcgatgccac tggaccaaca gagcattttg tggctatagg gtgcctgata ataatgtctt     3660

gatttttctt tgggattcaa ctatatcgaa ggtttttccc ccagcagtat gggggcgtac     3720

aggtgatcga tcattaatgt cattgcaatt gttatttttt aaaataaatt tataaaaata     3780

accgaaaagt aatgtgactt ttgaggaatc tgcaactcct gggttctagt ttgtgtttcc     3840

agtgttgaaa ttttgatctc ccccgacaag acttgtctgc atggacggtg tctctgtaaa     3900

cagtatcaaa cttgtaatgt ctgagcctct tagctttatc tccccttaat ttcttccctt     3960

ttggcccttc caccctgttg aggagatttt ttctgtcacc tgcaggctga tcatacattt     4020

gatgctacta ctgaaagtgt ttatcaaaat gtgatgaagt aattccatga ggaaaattag     4080

ccgttatcac aaaaacagcc ttaagtattg tagaatttca ggtagtgaag atgtactatt     4140

tacgttttgt tagattttgt tttggcagaa gaccaaaaca aaagtacttt tctgattgtt     4200

aaaaatccac agcatgctca ccttgttact gttttacctt acggtcgctg ggaatctaag     4260

caacaaagac tagaagcctc cgatatgcca ttatcaacac acaagagaca aacagcccga     4320

ggaagcactc aatgatgaga gcagtagacc tgccctggca gatgagagag gagaaactct     4380

ccacaatgaa ggaaaagcac tgacagtatt tgatagcttt agtcaaactg tgcttgagtt     4440

tggcttagat ttatgccagt ggaacctgtc cttaccaaat tcagagatga cccaagattc     4500

tactctgtgg tatgagggaa agacctctcg atatttatct cacaccaacg gctttatcgt     4560

aggagcgtct tcgcctcccc cgtttccagt agaaaagaca gctttgctcc tttgaaagcg     4620

cagaccgccg cacctccagc cccttctccc cggggaagta ggccccgcta agaatgtggg     4680

aaggtggtgg ggcggcgact gaagtcgctt ccgattggcg ttgtcccaag gaagcctgcg     4740

cggattgatc ggcggcaggc ctccaataga gcctgctagg cggattggct gctacgcggc     4800

tgggccctgt ttccggtacc taggcgggca gccatggtga ccggcgagcg gcatgcgacg     4860

ccgcctctgt ggcctgtgga ggcccgcttg gcggcgctgc ttcccgacct actggtcttt     4920

cggaagcctc ggggatggga acccgagctc gccacggccc agggcgtcct cctaggcgtc     4980

catgtgacgg gtgagggcga cggccggcac ttgcacttaa gtctcctggc ctgcgggaga     5040

ggcggccgtt gggtctaagc ccctggaggc ctcgacggtt acaggcctag cctcccgcga     5100

gctaaggcac agtttaactt cgtgctgcgg cttccttagg aaactttgag tatcttcgtt     5160

ttagcgtggg aggacatctt ttgggatgaa ccggctcagt ccttgagctc accccaaaga     5220

tgatgaaatt gaaactcaga ggaaaggatt tttacaggac cacgccccgg gctttgaacc     5280

cgtttttccc aaccccgagc attttctatt aagcgttctg tttcaattat tttattcgtt     5340

cagttaattc gttcttggcg tcataagtat atgcccgccg ttgttctggc cgtagctatc     5400

tagcagccac tccgcgagtc gttcatttaa caaatactta ctctgtgtca gggatatgaa     5460

gatgggtaat accaggtgcc tgtcctcact gtgtgagtgg ttctctagcc agacatgagg     5520

agggatccta ttgtttccca tagctaggca gcctaagaga gtaggggaaa gagctggctc     5580

cagatgaaaa gggcaccatc tccagctctt ggaagcagag agggtggtcc tttggattcc     5640

cagtggcagc agcaaccaac ctggccctta gtagtttcta agttacacca tgttaatgga     5700

taaaggaatt actcagcttg aagggatctg tttcctttac actggcctga tgtgtgggga     5760

gaaaggggcc aaaaagttta ggatttggag ttaacatcgt aatttctgct ttgttggtca     5820

gggtttacag cattaatgga caggttcacc ctgacctaca agtcggaacg tgacatggac     5880

aaactggccc atatcttcag ttattacatt agtgacatcg tggagcgtga gtgatcattg     5940

tagggtaaca aggtgtggtg ctgggctcct gggggtttat aaaagaaggg ggccagaagt     6000

actttaaaac aggtaccaaa gggtcattcc tttagcatca ttcatctttg gtttcttcaa     6060

gttgccactg aaaagctaga cctttgccta ttatctgcta atctacccag tctcacattc     6120

tattgactca ttgttcaaag ggggggcagg aggagctaat ttcctttgca catttgtatt     6180

ttatttcaaa ataaagtatt ctcttctaac aataacgtaa aaaaaaaaaa aaaaaa         6236


<210>  250
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Glu Gln Tyr Thr Ala Asn Ser Asn Ser Ser Thr Glu Gln Ile Val 
1               5                   10                  15      


Val Gln Ala Gly Gln Ile Gln Gln Gln Gln Gln Gly Gly Val Thr Ala 
            20                  25                  30          


Val Gln Leu Gln Thr Glu Ala Gln Val Ala Ser Ala Ser Gly Gln Gln 
        35                  40                  45              


Val Gln Thr Leu Gln Val Val Gln Gly Gln Pro Leu Met Val Gln Val 
    50                  55                  60                  


Ser Gly Gly Gln Leu Ile Thr Ser Thr Gly Gln Pro Ile Met Val Gln 
65                  70                  75                  80  


Ala Val Pro Gly Gly Gln Gly Gln Thr Ile Met Gln Val Pro Val Ser 
                85                  90                  95      


Gly Thr Gln Gly Leu Gln Gln Ile Gln Leu Val Pro Pro Gly Gln Ile 
            100                 105                 110         


Gln Ile Gln Gly Gly Gln Ala Val Gln Val Gln Gly Gln Gln Gly Gln 
        115                 120                 125             


Thr Gln Gln Ile Ile Ile Gln Gln Pro Gln Thr Ala Val Thr Ala Gly 
    130                 135                 140                 


Gln Thr Gln Thr Gln Gln Gln Ile Ala Val Gln Gly Gln Gln Val Ala 
145                 150                 155                 160 


Gln Thr Ala Glu Gly Gln Thr Ile Val Tyr Gln Pro Val Asn Ala Asp 
                165                 170                 175     


Gly Thr Ile Leu Gln Gln Val Thr Val Pro Val Ser Gly Met Ile Thr 
            180                 185                 190         


Ile Pro Ala Ala Ser Leu Ala Gly Ala Gln Ile Val Gln Thr Gly Ala 
        195                 200                 205             


Asn Thr Asn Thr Thr Ser Ser Gly Gln Gly Thr Val Thr Val Thr Leu 
    210                 215                 220                 


Pro Val Ala Gly Asn Val Val Asn Ser Gly Gly Met Val Met Met Val 
225                 230                 235                 240 


Pro Gly Ala Gly Ser Val Pro Ala Ile Gln Arg Ile Pro Leu Pro Gly 
                245                 250                 255     


Ala Glu Met Leu Glu Glu Glu Pro Leu Tyr Val Asn Ala Lys Gln Tyr 
            260                 265                 270         


His Arg Ile Leu Lys Arg Arg Gln Ala Arg Ala Lys Leu Glu Ala Glu 
        275                 280                 285             


Gly Lys Ile Pro Lys Glu Arg Arg Lys Tyr Leu His Glu Ser Arg His 
    290                 295                 300                 


Arg His Ala Met Ala Arg Lys Arg Gly Glu Gly Gly Arg Phe Phe Ser 
305                 310                 315                 320 


Pro Lys Glu Lys Asp Ser Pro His Met Gln Asp Pro Asn Gln Ala Asp 
                325                 330                 335     


Glu Glu Ala Met Thr Gln Ile Ile Arg Val Ser 
            340                 345         


<210>  251
<211>  6149
<212>  DNA
<213>  Homo sapiens

<400>  251
cattttgcta ggcagcggca gtggcggcgg cagcggcggc tggagcctct gattgggttt       60

cggagtccgg tactggagcc aatcagcgcg ggcagcgaac cgggggagcg aggcacggag      120

tgtacctcac agccttctag gatctccaga gtggacagga atctcacttg gagggaccat      180

ggagcagtat acagcaaaca gcaatagttc gacagagcag attgttgtcc aggcaggaca      240

gattcagcag caggtccaag ggcagccatt aatggtgcag gtcagtggag gccagctaat      300

cacatcaact ggccaaccca tcatggtcca ggctgtccct ggtggacaag gtcaaaccat      360

catgcaagta cctgtttctg gaacacaggg tttgcagcaa atacagttgg tcccacctgg      420

acagatccag atccagggtg gacaggctgt gcaggtgcag ggccagcagg gccagaccca      480

gcagatcatc atccagcagc cccagacggc tgtcactgct ggccagactc agacacagca      540

gcagattgct gtccagggac agcaagtggc acagactgct gaagggcaga ccatcgtcta      600

tcaaccagtt aatgcagatg gcaccattct ccagcaagtt acagtccctg tttcaggcat      660

gatcactatc ccagcagcca gtttggcagg agcacagatt gttcaaacag gagccaatac      720

caacacaacc agcagtgggc aagggactgt cactgtgaca ctaccagtgg caggcaatgt      780

ggtcaattca ggagggatgg tcatgatggt tcctggggct ggctctgtgc ctgctatcca      840

aagaatccct ctacctggag cagagatgct tgaagaagag cctctctacg tgaatgccaa      900

acaataccac cgtattctta agaggaggca agcccgagct aaactagagg cagaagggaa      960

aattccaaag gagagaagga aatacctgca tgagtctcgg caccgtcatg ccatggcacg     1020

gaagcgtggt gaaggtggac gatttttctc tccaaaggaa aaggatagtc cccatatgca     1080

ggatccaaac caagccgatg aagaagcaat gacacagatc atccgagtgt cctaacccca     1140

cgccatgtga tggagctgat caaggtcatg tttctcactg ttccaggaaa ttgatcaact     1200

cttccaatgg gacattgatg atcacattct gccctttact acaggacaga aaccacttag     1260

tttttaataa gtggctcagt attacaattg cagcgatgcc tggcaaattg aagttgcaag     1320

cctttgtctt actctttcag tcaggaccta tttcagactg ttgatgacat tgacatttca     1380

tggattcgga tgatgcaagg agacacatgc caccccagca gtacacaaag cacttacctt     1440

gactggtgaa gtcagccagc catctcagca gggaagaaca accttctcaa ccaaaactgc     1500

aatcaggaaa gcagcagccc actccttccc atggaatcta gacagcattt atccctctgg     1560

tgggggaatc tcacactgac taactgaatg gacgctttgt attcagagat ggcttccagg     1620

caaggaagtt ctatcttgtg atacggaaac aataaattcc tgagatacat tcttccaatc     1680

tgtggtaata ataagaattc ctctctgccc agatggtagg ttgatatttc tggactctag     1740

ccaagaaaaa gctaattctg gggatagaat gataaaagac tcaagcacta aaaatataca     1800

ttgccgaatc tctttttcta gctttgaaaa gttgtggcct gcttgtccct ctgttgactg     1860

gtcatctgga ccatcgtact tgctgtggct acttctaaga caatgtagag ggttattaaa     1920

ccttgaaact gcctttccta agtagagaac aagactattc aacaacttct ttgctgaagc     1980

actgaggaga tttgtaatac tcctaaagga agggccaaac tagagatttt caatcataga     2040

ctttgtgaca gcatttgggg aactaaaaga ttcatgtgtt tcagcctagt gggagagagt     2100

gggggagagg aagagagaga gagagcatgt atacccgtat gttatcatag agcacgattc     2160

tccagtggat ggatacctgg aatggatcat taagatgaag agagtaattc acatttactc     2220

tagaaccttt aacaagcact gaaaggaaga agcctgagat ttgatccttg acaatttctg     2280

gaaagcactg gtcagtcaca ctgtcctgga cagagtccaa gttacccact aaagcttgag     2340

gtggatgttg gcttcactcc tgcagcacaa tgctggccct agaaagcgag cattttcatt     2400

cttcccatgg cagctgattc tttggtgcca gttttcatgt tttctccata ggccttgtgc     2460

agaaaggttt tctcattgca tccatactgt gagaataaac tgcagactga aagaaacatg     2520

cctgcagggt caggaactgg gccactgttc ccagaacggg ttgtgcctca gaaatctatt     2580

tctcttttag atgttgaacc ctgagagaac taagatgata tttcagaaga gttggctgcc     2640

ttctctggaa acaaggaaaa cccaataatt ccgaggaaca ttgggggtta aataccaaga     2700

ataaaaattg gttcttcttt gacttcagct taactgtatt aagacagaaa ttaagccctc     2760

taaaaacacc acaaagagag atgattgtaa tgatagaaat agaggtacag agctatgcaa     2820

aggaaacagg aagtgaaata ttcctagtcc cagggatctg gtaatcgctc ctggcttcca     2880

gatgtcaaag gactgatcct ttggtaagct cactagaaac ttctagctct acaagagttt     2940

gggatattaa tgttattcag taagtcccaa gtttttcaga gaatagatta ctaacaatga     3000

ggaatttata ttccttggtt aatttaggag tctaagatgc agagttcaga aagaaattac     3060

tcagacctaa ctttgagtgc ttaagctgcc aacagttaga agatgctatt tatttgtgtc     3120

tgtaagtttg tacatagtaa tgccagcctt gttgctgaat tttttatttg gggggagatg     3180

actttgaatt ttgtttgaaa tgcttcagtt gtcattttgt cattgcattt caaatagctc     3240

atgacccttt tcttgtggtc actttggcac accatagtag cccacaaagt gggggcaggg     3300

tattgacatt tggatttttt ctttgatact agttctttta ttcattttta tttgtgactg     3360

tagtgataac tttacagatg gagaaagagt gaatggatga atgaataatt ggtttaatgc     3420

ctagttatgc aacttgagtg cttttttttt tttttgcagg ataattttaa gtgtatatat     3480

tttaactgca ctggtacatt gaacatgtca gtgtcgatgc cactggacca acagagcatt     3540

ttgtggctat agggtgcctg ataataatgt cttgattttt ctttgggatt caactatatc     3600

gaaggttttt cccccagcag tatgggggcg tacaggtgat cgatcattaa tgtcattgca     3660

attgttattt tttaaaataa atttataaaa ataaccgaaa agtaatgtga cttttgagga     3720

atctgcaact cctgggttct agtttgtgtt tccagtgttg aaattttgat ctcccccgac     3780

aagacttgtc tgcatggacg gtgtctctgt aaacagtatc aaacttgtaa tgtctgagcc     3840

tcttagcttt atctcccctt aatttcttcc cttttggccc ttccaccctg ttgaggagat     3900

tttttctgtc acctgcaggc tgatcataca tttgatgcta ctactgaaag tgtttatcaa     3960

aatgtgatga agtaattcca tgaggaaaat tagccgttat cacaaaaaca gccttaagta     4020

ttgtagaatt tcaggtagtg aagatgtact atttacgttt tgttagattt tgttttggca     4080

gaagaccaaa acaaaagtac ttttctgatt gttaaaaatc cacagcatgc tcaccttgtt     4140

actgttttac cttacggtcg ctgggaatct aagcaacaaa gactagaagc ctccgatatg     4200

ccattatcaa cacacaagag acaaacagcc cgaggaagca ctcaatgatg agagcagtag     4260

acctgccctg gcagatgaga gaggagaaac tctccacaat gaaggaaaag cactgacagt     4320

atttgatagc tttagtcaaa ctgtgcttga gtttggctta gatttatgcc agtggaacct     4380

gtccttacca aattcagaga tgacccaaga ttctactctg tggtatgagg gaaagacctc     4440

tcgatattta tctcacacca acggctttat cgtaggagcg tcttcgcctc ccccgtttcc     4500

agtagaaaag acagctttgc tcctttgaaa gcgcagaccg ccgcacctcc agccccttct     4560

ccccggggaa gtaggccccg ctaagaatgt gggaaggtgg tggggcggcg actgaagtcg     4620

cttccgattg gcgttgtccc aaggaagcct gcgcggattg atcggcggca ggcctccaat     4680

agagcctgct aggcggattg gctgctacgc ggctgggccc tgtttccggt acctaggcgg     4740

gcagccatgg tgaccggcga gcggcatgcg acgccgcctc tgtggcctgt ggaggcccgc     4800

ttggcggcgc tgcttcccga cctactggtc tttcggaagc ctcggggatg ggaacccgag     4860

ctcgccacgg cccagggcgt cctcctaggc gtccatgtga cgggtgaggg cgacggccgg     4920

cacttgcact taagtctcct ggcctgcggg agaggcggcc gttgggtcta agcccctgga     4980

ggcctcgacg gttacaggcc tagcctcccg cgagctaagg cacagtttaa cttcgtgctg     5040

cggcttcctt aggaaacttt gagtatcttc gttttagcgt gggaggacat cttttgggat     5100

gaaccggctc agtccttgag ctcaccccaa agatgatgaa attgaaactc agaggaaagg     5160

atttttacag gaccacgccc cgggctttga acccgttttt cccaaccccg agcattttct     5220

attaagcgtt ctgtttcaat tattttattc gttcagttaa ttcgttcttg gcgtcataag     5280

tatatgcccg ccgttgttct ggccgtagct atctagcagc cactccgcga gtcgttcatt     5340

taacaaatac ttactctgtg tcagggatat gaagatgggt aataccaggt gcctgtcctc     5400

actgtgtgag tggttctcta gccagacatg aggagggatc ctattgtttc ccatagctag     5460

gcagcctaag agagtagggg aaagagctgg ctccagatga aaagggcacc atctccagct     5520

cttggaagca gagagggtgg tcctttggat tcccagtggc agcagcaacc aacctggccc     5580

ttagtagttt ctaagttaca ccatgttaat ggataaagga attactcagc ttgaagggat     5640

ctgtttcctt tacactggcc tgatgtgtgg ggagaaaggg gccaaaaagt ttaggatttg     5700

gagttaacat cgtaatttct gctttgttgg tcagggttta cagcattaat ggacaggttc     5760

accctgacct acaagtcgga acgtgacatg gacaaactgg cccatatctt cagttattac     5820

attagtgaca tcgtggagcg tgagtgatca ttgtagggta acaaggtgtg gtgctgggct     5880

cctgggggtt tataaaagaa gggggccaga agtactttaa aacaggtacc aaagggtcat     5940

tcctttagca tcattcatct ttggtttctt caagttgcca ctgaaaagct agacctttgc     6000

ctattatctg ctaatctacc cagtctcaca ttctattgac tcattgttca aagggggggc     6060

aggaggagct aatttccttt gcacatttgt attttatttc aaaataaagt attctcttct     6120

aacaataacg taaaaaaaaa aaaaaaaaa                                       6149


<210>  252
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Glu Gln Tyr Thr Ala Asn Ser Asn Ser Ser Thr Glu Gln Ile Val 
1               5                   10                  15      


Val Gln Ala Gly Gln Ile Gln Gln Gln Val Gln Gly Gln Pro Leu Met 
            20                  25                  30          


Val Gln Val Ser Gly Gly Gln Leu Ile Thr Ser Thr Gly Gln Pro Ile 
        35                  40                  45              


Met Val Gln Ala Val Pro Gly Gly Gln Gly Gln Thr Ile Met Gln Val 
    50                  55                  60                  


Pro Val Ser Gly Thr Gln Gly Leu Gln Gln Ile Gln Leu Val Pro Pro 
65                  70                  75                  80  


Gly Gln Ile Gln Ile Gln Gly Gly Gln Ala Val Gln Val Gln Gly Gln 
                85                  90                  95      


Gln Gly Gln Thr Gln Gln Ile Ile Ile Gln Gln Pro Gln Thr Ala Val 
            100                 105                 110         


Thr Ala Gly Gln Thr Gln Thr Gln Gln Gln Ile Ala Val Gln Gly Gln 
        115                 120                 125             


Gln Val Ala Gln Thr Ala Glu Gly Gln Thr Ile Val Tyr Gln Pro Val 
    130                 135                 140                 


Asn Ala Asp Gly Thr Ile Leu Gln Gln Val Thr Val Pro Val Ser Gly 
145                 150                 155                 160 


Met Ile Thr Ile Pro Ala Ala Ser Leu Ala Gly Ala Gln Ile Val Gln 
                165                 170                 175     


Thr Gly Ala Asn Thr Asn Thr Thr Ser Ser Gly Gln Gly Thr Val Thr 
            180                 185                 190         


Val Thr Leu Pro Val Ala Gly Asn Val Val Asn Ser Gly Gly Met Val 
        195                 200                 205             


Met Met Val Pro Gly Ala Gly Ser Val Pro Ala Ile Gln Arg Ile Pro 
    210                 215                 220                 


Leu Pro Gly Ala Glu Met Leu Glu Glu Glu Pro Leu Tyr Val Asn Ala 
225                 230                 235                 240 


Lys Gln Tyr His Arg Ile Leu Lys Arg Arg Gln Ala Arg Ala Lys Leu 
                245                 250                 255     


Glu Ala Glu Gly Lys Ile Pro Lys Glu Arg Arg Lys Tyr Leu His Glu 
            260                 265                 270         


Ser Arg His Arg His Ala Met Ala Arg Lys Arg Gly Glu Gly Gly Arg 
        275                 280                 285             


Phe Phe Ser Pro Lys Glu Lys Asp Ser Pro His Met Gln Asp Pro Asn 
    290                 295                 300                 


Gln Ala Asp Glu Glu Ala Met Thr Gln Ile Ile Arg Val Ser 
305                 310                 315             


<210>  253
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  253
ggcggccagc ggccccggcc cggggcctgc gagcgcctcg gggcactccc ggccgaggcc       60

tgcaggggcc gccccgcgcg gggatggcgc ctcggggagc aggcacctcg gggctccgac      120

cctcgcaggg tgccagggcc agttgggaat gcgtccctgt tccccgactc aggcccaggt      180

tctcaggccc caggcctggg gccacgaatg gccctacact aggggacaca tgcgcgccct      240

gggcctcggc gatttcctcc tggtcgttct ggccgcaaac ttaaacctgc ccttgcactc      300

tccactctcc ggcccttggg acaggaagcc tccccggggc ccgcgccccc cgctccccgc      360

tcccagcgag ccggggcttt cctctgtcat ccaggctgga gtacagtggc gcaatcgtag      420

ctcactaacc tggaactcct gggctcaagc catcctccct tcttgttctc ccaaaacgtt      480

gggattacag gcatga                                                      496


<210>  254
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Arg Pro Cys Ser Pro Thr Gln Ala Gln Val Leu Arg Pro Gln Ala 
1               5                   10                  15      


Trp Gly His Glu Trp Pro Tyr Thr Arg Gly His Met Arg Ala Leu Gly 
            20                  25                  30          


Leu Gly Asp Phe Leu Leu Val Val Leu Ala Ala Asn Leu Asn Leu Pro 
        35                  40                  45              


Leu His Ser Pro Leu Ser Gly Pro Trp Asp Arg Lys Pro Pro Arg Gly 
    50                  55                  60                  


Pro Arg Pro Pro Leu Pro Ala Pro Ser Glu Pro Gly Leu Ser Ser Val 
65                  70                  75                  80  


Ile Gln Ala Gly Val Gln Trp Arg Asn Arg Ser Ser Leu Thr Trp Asn 
                85                  90                  95      


Ser Trp Ala Gln Ala Ile Leu Pro Ser Cys Ser Pro Lys Thr Leu Gly 
            100                 105                 110         


Leu Gln Ala 
        115 


<210>  255
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  255
ggcggccagc ggccccggcc cggggcctgc gagcgcctcg gggcactccc ggccgaggcc       60

tgcaggggcc gccccgcgcg gggatggcgc ctcggggagc aggcacctcg gggctccgac      120

cctcgcaggg tgccagggcc agttgggaat gcgtccctgt tccccgactc aggcccaggt      180

tctcaggccc caggcctggg gccacgaatg gccctacact aggggacaca tgcgcgccct      240

gggcctcggc gatttcctcc tggtcgttct ggccgcaaac ttaaacctgc ccttgcactc      300

tccactctcc ggcccttggg acaggaagcc tccccggggc ccgcgccccc cgctccccgc      360

tcccagcgag ccggggcttt cctctgtcat ccaggctgga gtacagtggc gcaatcgtag      420

ctcactaacc tggaactcct gggctcaagc catcctccct tcttgttctc ccaaaacgtt      480

gggattacag gcatga                                                      496


<210>  256
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Arg Pro Cys Ser Pro Thr Gln Ala Gln Val Leu Arg Pro Gln Ala 
1               5                   10                  15      


Trp Gly His Glu Trp Pro Tyr Thr Arg Gly His Met Arg Ala Leu Gly 
            20                  25                  30          


Leu Gly Asp Phe Leu Leu Val Val Leu Ala Ala Asn Leu Asn Leu Pro 
        35                  40                  45              


Leu His Ser Pro Leu Ser Gly Pro Trp Asp Arg Lys Pro Pro Arg Gly 
    50                  55                  60                  


Pro Arg Pro Pro Leu Pro Ala Pro Ser Glu Pro Gly Leu Ser Ser Val 
65                  70                  75                  80  


Ile Gln Ala Gly Val Gln Trp Arg Asn Arg Ser Ser Leu Thr Trp Asn 
                85                  90                  95      


Ser Trp Ala Gln Ala Ile Leu Pro Ser Cys Ser Pro Lys Thr Leu Gly 
            100                 105                 110         


Leu Gln Ala 
        115 


<210>  257
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  257
ggcggccagc ggccccggcc cggggcctgc gagcgcctcg gggcactccc ggccgaggcc       60

tgcaggggcc gccccgcgcg gggatggcgc ctcggggagc aggcacctcg gggctccgac      120

cctcgcaggg tgccagggcc agttgggaat gcgtccctgt tccccgactc aggcccaggt      180

tctcaggccc caggcctggg gccacgaatg gccctacact aggggacaca tgcgcgccct      240

gggcctcggc gatttcctcc tggtcgttct ggccgcaaac ttaaacctgc ccttgcactc      300

tccactctcc ggcccttggg acaggaagcc tccccggggc ccgcgccccc cgctccccgc      360

tcccagcgag ccggggcttt cctctgtcat ccaggctgga gtacagtggc gcaatcgtag      420

ctcactaacc tggaactcct gggctcaagc catcctccct tcttgttctc ccaaaacgtt      480

gggattacag tacttcacct tcctccacat catcacatag                            520


<210>  258
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Arg Pro Cys Ser Pro Thr Gln Ala Gln Val Leu Arg Pro Gln Ala 
1               5                   10                  15      


Trp Gly His Glu Trp Pro Tyr Thr Arg Gly His Met Arg Ala Leu Gly 
            20                  25                  30          


Leu Gly Asp Phe Leu Leu Val Val Leu Ala Ala Asn Leu Asn Leu Pro 
        35                  40                  45              


Leu His Ser Pro Leu Ser Gly Pro Trp Asp Arg Lys Pro Pro Arg Gly 
    50                  55                  60                  


Pro Arg Pro Pro Leu Pro Ala Pro Ser Glu Pro Gly Leu Ser Ser Val 
65                  70                  75                  80  


Ile Gln Ala Gly Val Gln Trp Arg Asn Arg Ser Ser Leu Thr Trp Asn 
                85                  90                  95      


Ser Trp Ala Gln Ala Ile Leu Pro Ser Cys Ser Pro Lys Thr Leu Gly 
            100                 105                 110         


Leu Gln Tyr Phe Thr Phe Leu His Ile Ile Thr 
        115                 120             


<210>  259
<211>  4364
<212>  DNA
<213>  Homo sapiens

<400>  259
ggcggggccg cgcacgcagc cgccgccacc acttccccct ctccctccct ccttgcgggc       60

cctcctcccc ttccctcccc tccgccccct tccccgtagg cagcccgccc gccagtccgc      120

ccgcaccgcc tccttcccag cccctagcgc tccggctggg tctctccccc gccccccagg      180

ctcccccggt cgctctcctc cggcggtcgc ccgcgctcgg tggatgtggc tggcagctgc      240

cgccccctcc ctcgctcgcc gcctgctctt cctcggccct ccgcctcctc ccctcctcct      300

tctcgtcttc agccgctcct ctcgccgccg cctccacagc ctgggcctcg ccgcgatgcc      360

ggagaagagg cccttcgagc ggctgcctgc cgatgtctcc cccatcaact acagcctttg      420

cctcaagccc gacttgctgg acttcacctt cgagggcaag ctggaggccg ccgcccaggt      480

gaggcaggcg actaatcaga ttgtgatgaa ttgtgctgat attgatatta ttacagcttc      540

atatgcacca gaaggagatg aagaaataca tgctacagga tttaactatc agaatgaaga      600

tgaaaaagtc accttgtctt tccctagtac tctgcaaaca ggtacgggaa ccttaaagat      660

agattttgtt ggagagctga atgacaaaat gaaaggtttc tatagaagta aatatactac      720

cccttctgga gaggtgcgct atgctgctgt aacacagttt gaggctactg atgcccgaag      780

ggcttttcct tgctgggatg agcctgctat caaagcaact tttgatatct cattggttgt      840

tcctaaagac agagtagctt tatcaaacat gaatgtaatt gaccggaaac cataccctga      900

tgatgaaaat ttagtggaag tgaagtttgc ccgcacacct gttatgtcta catatctggt      960

ggcatttgtt gtgggtgaat atgactttgt agaaacaagg tcaaaagatg gtgtgtgtgt     1020

ccgtgtttac actcctgttg gcaaagcaga gcaaggaaaa tttgcgttag aggttgctgc     1080

taaaaccttg cctttttata aggactactt caatgttcct tatcctctac ctaaaattga     1140

tctcattgct attgcagact ttgcagctgg tgccatggag aactggggcc ttgttactta     1200

tagggagact gcattgctta ttgatccaaa aaattcctgt tcttcatccc gccagtgggt     1260

tgctctggtt gtgggacatg aactcgccca tcaatggttt ggaaatcttg ttactatgga     1320

atggtggact catctttggt taaatgaagg ttttgcatcc tggattgaat atctgtgtgt     1380

agaccactgc ttcccagagt atgatatttg gactcagttt gtttctgctg attacacccg     1440

tgcccaggag cttgacgcct tagataacag ccatcctatt gaagtcagtg tgggccatcc     1500

atctgaggtt gatgagatat ttgatgctat atcatatagc aaaggtgcat ctgtcatccg     1560

aatgctgcat gactacattg gggataagga ctttaagaaa ggaatgaaca tgtatttaac     1620

caagttccaa caaaagaatg ctgccacaga ggatctctgg gaaagtttag aaaatgctag     1680

tggtaaacct atagcagctg tgatgaatac ctggaccaaa caaatgggat ttcccctcat     1740

ttatgtggaa gctgaacagg tagaagatga cagattattg aggttgtccc aaaagaagtt     1800

ctgtgctggt gggtcatatg ttggtgaaga ttgtccccag tggatggtcc ctatcacaat     1860

ctctactagt gaagacccca accaggccaa actaaaaatt ctaatggaca agccagagat     1920

gaatgtggtt ttgaaaaatg tcaaaccaga ccaatgggtg aagttaaact taggaacagt     1980

tgggttttat cggacccagt acagctctgc catgctggaa agtttattac caggcattcg     2040

tgacctttct ctgccccctg tggatcgact tggattacag aatgacctct tctccttggc     2100

tcgagctgga atcattagca ctgtagaggt tctaaaagtc atggaggctt ttgtgaatga     2160

gcccaattat actgtatgga gcgacctgag ctgtaacctg gggattctct caactctctt     2220

gtcccacaca gacttctatg aggaaatcca ggagtttgtg aaagatgtct tttcacctat     2280

aggggagaga ctgggctggg accccaaacc tggagaaggt catctcgatg cactcctgag     2340

gggcttggtt ctgggaaaac taggaaaagc aggacataag gcaacgttag aagaagcccg     2400

tcgtcggttt aaggaccacg tggaaggaaa acagattctc tccgctgatc tgaggagtcc     2460

tgtctatctg actgttttga agcatggtga tggcactact ttagatatta tgttaaaact     2520

tcataaacaa gcagatatgc aagaagagaa aaaccgaatc gaaagagtcc ttggcgctac     2580

tcttttgcct gacctgattc aaaaagtcct cacgtttgca ctttcagaag aggtacgtcc     2640

acaggacact gtatcggtaa ttggtggagt agctggaggc agcaagcatg gtaggaaagc     2700

tgcttggaaa ttcataaagg acaactggga agaactttat aaccgatacc agggaggatt     2760

cttaatatcc agactaataa agctatcagt tgagggattt gcagttgata aaatggctgg     2820

agaggttaag gctttcttcg agagtcaccc agctccttca gctgagcgta ccatccagca     2880

gtgttgtgaa aatattctgc tgaatgctgc ctggctaaag cgagatgctg agagcatcca     2940

ccagtacctc cttcagcgga aggcctcacc acccacagtg tgaatcctga ggtgccgcca     3000

ttggcggttc tgctgcttcg ctgcagggat aaggtggagc taccgaacag ctgattcata     3060

tgccaagaat ttggagtctt ctttcaaacc agtgggggtt ggacaatgaa tgtagttaac     3120

tggttcctgc tcacactcca gaattaaatt ctattgaaaa aggaaaatca gcaattcagc     3180

aaaaaataaa taaaaaataa aaatgtaaat atgatagtaa taaaatagag cataacgaaa     3240

ctgtgaaact ttctgaagcc ttgtcagtgg ttaaaagtat ttaacactct actgttaatg     3300

acagatgttc tgtttttata acctaccaaa aggaaactag aggcttcttg gtgaagagca     3360

tttttgtgaa gtgggttctg caaggagcct ataaagccaa gggtggtgtc catttctggg     3420

aatggttaaa cacaaaaggc tgatagctgg tatcacatag ttggagtcag tgcataattc     3480

caagtggctt tttttttttt tggcacgggg actgatcagg aagatatatt cctgcataac     3540

tcaatctgaa ccaaggattg tagtttagtt ttcctccttg ccttcccttc tgtgtgaccg     3600

accccttggc caaaaaaaaa caaaaagcaa aaaacaaaaa cctaccctgt tctggttttt     3660

ttcctccctt tagttccacc cccaaccccc attccctggt gtccttctta gagatgaaga     3720

aataataagg aaacatcttt catagccaca ttaaataaga gaaactgata tacattattt     3780

ttttcttttt aaagatgact tataagaacc ctgaaattta tataggtgag acaatagaaa     3840

taaaaagatc ttcagccagg cctttctgaa ggagttattc tgctaaaaat ggtcttagtt     3900

gtctgaaaag ccagctcttg aacctcttca caacagtatc aacactggct tctcccggtt     3960

cattttatgc gtgcgagaag tcagtggtaa ctgctgcagg gcttaataca ttagtggtaa     4020

ctggtttaaa aaacaaagac tgtaagcctg tgtgtgccac tgtttgcttc aacagtatat     4080

cctaataagc ctcacctatt taatccaatg agttttaaat ctaaatctca ttcccttctt     4140

ctttccctac cttttttttc tttttttctt aaaaaaatat tttgtgttat taacagaaat     4200

tcatatttgg tgtggcttaa cggtatttca gaaggtcatc agattgtgag actgcttcct     4260

tgaaacattt ttgtgctatt gttttaaaaa aataattaaa aaacagttgg cgttaataaa     4320

aatgtcaatg tgaaactgaa aaaaaaaaaa aaaaaaaaaa aaaa                      4364


<210>  260
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Trp Leu Ala Ala Ala Ala Pro Ser Leu Ala Arg Arg Leu Leu Phe 
1               5                   10                  15      


Leu Gly Pro Pro Pro Pro Pro Leu Leu Leu Leu Val Phe Ser Arg Ser 
            20                  25                  30          


Ser Arg Arg Arg Leu His Ser Leu Gly Leu Ala Ala Met Pro Glu Lys 
        35                  40                  45              


Arg Pro Phe Glu Arg Leu Pro Ala Asp Val Ser Pro Ile Asn Tyr Ser 
    50                  55                  60                  


Leu Cys Leu Lys Pro Asp Leu Leu Asp Phe Thr Phe Glu Gly Lys Leu 
65                  70                  75                  80  


Glu Ala Ala Ala Gln Val Arg Gln Ala Thr Asn Gln Ile Val Met Asn 
                85                  90                  95      


Cys Ala Asp Ile Asp Ile Ile Thr Ala Ser Tyr Ala Pro Glu Gly Asp 
            100                 105                 110         


Glu Glu Ile His Ala Thr Gly Phe Asn Tyr Gln Asn Glu Asp Glu Lys 
        115                 120                 125             


Val Thr Leu Ser Phe Pro Ser Thr Leu Gln Thr Gly Thr Gly Thr Leu 
    130                 135                 140                 


Lys Ile Asp Phe Val Gly Glu Leu Asn Asp Lys Met Lys Gly Phe Tyr 
145                 150                 155                 160 


Arg Ser Lys Tyr Thr Thr Pro Ser Gly Glu Val Arg Tyr Ala Ala Val 
                165                 170                 175     


Thr Gln Phe Glu Ala Thr Asp Ala Arg Arg Ala Phe Pro Cys Trp Asp 
            180                 185                 190         


Glu Pro Ala Ile Lys Ala Thr Phe Asp Ile Ser Leu Val Val Pro Lys 
        195                 200                 205             


Asp Arg Val Ala Leu Ser Asn Met Asn Val Ile Asp Arg Lys Pro Tyr 
    210                 215                 220                 


Pro Asp Asp Glu Asn Leu Val Glu Val Lys Phe Ala Arg Thr Pro Val 
225                 230                 235                 240 


Met Ser Thr Tyr Leu Val Ala Phe Val Val Gly Glu Tyr Asp Phe Val 
                245                 250                 255     


Glu Thr Arg Ser Lys Asp Gly Val Cys Val Arg Val Tyr Thr Pro Val 
            260                 265                 270         


Gly Lys Ala Glu Gln Gly Lys Phe Ala Leu Glu Val Ala Ala Lys Thr 
        275                 280                 285             


Leu Pro Phe Tyr Lys Asp Tyr Phe Asn Val Pro Tyr Pro Leu Pro Lys 
    290                 295                 300                 


Ile Asp Leu Ile Ala Ile Ala Asp Phe Ala Ala Gly Ala Met Glu Asn 
305                 310                 315                 320 


Trp Gly Leu Val Thr Tyr Arg Glu Thr Ala Leu Leu Ile Asp Pro Lys 
                325                 330                 335     


Asn Ser Cys Ser Ser Ser Arg Gln Trp Val Ala Leu Val Val Gly His 
            340                 345                 350         


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp Trp 
        355                 360                 365             


Thr His Leu Trp Leu Asn Glu Gly Phe Ala Ser Trp Ile Glu Tyr Leu 
    370                 375                 380                 


Cys Val Asp His Cys Phe Pro Glu Tyr Asp Ile Trp Thr Gln Phe Val 
385                 390                 395                 400 


Ser Ala Asp Tyr Thr Arg Ala Gln Glu Leu Asp Ala Leu Asp Asn Ser 
                405                 410                 415     


His Pro Ile Glu Val Ser Val Gly His Pro Ser Glu Val Asp Glu Ile 
            420                 425                 430         


Phe Asp Ala Ile Ser Tyr Ser Lys Gly Ala Ser Val Ile Arg Met Leu 
        435                 440                 445             


His Asp Tyr Ile Gly Asp Lys Asp Phe Lys Lys Gly Met Asn Met Tyr 
    450                 455                 460                 


Leu Thr Lys Phe Gln Gln Lys Asn Ala Ala Thr Glu Asp Leu Trp Glu 
465                 470                 475                 480 


Ser Leu Glu Asn Ala Ser Gly Lys Pro Ile Ala Ala Val Met Asn Thr 
                485                 490                 495     


Trp Thr Lys Gln Met Gly Phe Pro Leu Ile Tyr Val Glu Ala Glu Gln 
            500                 505                 510         


Val Glu Asp Asp Arg Leu Leu Arg Leu Ser Gln Lys Lys Phe Cys Ala 
        515                 520                 525             


Gly Gly Ser Tyr Val Gly Glu Asp Cys Pro Gln Trp Met Val Pro Ile 
    530                 535                 540                 


Thr Ile Ser Thr Ser Glu Asp Pro Asn Gln Ala Lys Leu Lys Ile Leu 
545                 550                 555                 560 


Met Asp Lys Pro Glu Met Asn Val Val Leu Lys Asn Val Lys Pro Asp 
                565                 570                 575     


Gln Trp Val Lys Leu Asn Leu Gly Thr Val Gly Phe Tyr Arg Thr Gln 
            580                 585                 590         


Tyr Ser Ser Ala Met Leu Glu Ser Leu Leu Pro Gly Ile Arg Asp Leu 
        595                 600                 605             


Ser Leu Pro Pro Val Asp Arg Leu Gly Leu Gln Asn Asp Leu Phe Ser 
    610                 615                 620                 


Leu Ala Arg Ala Gly Ile Ile Ser Thr Val Glu Val Leu Lys Val Met 
625                 630                 635                 640 


Glu Ala Phe Val Asn Glu Pro Asn Tyr Thr Val Trp Ser Asp Leu Ser 
                645                 650                 655     


Cys Asn Leu Gly Ile Leu Ser Thr Leu Leu Ser His Thr Asp Phe Tyr 
            660                 665                 670         


Glu Glu Ile Gln Glu Phe Val Lys Asp Val Phe Ser Pro Ile Gly Glu 
        675                 680                 685             


Arg Leu Gly Trp Asp Pro Lys Pro Gly Glu Gly His Leu Asp Ala Leu 
    690                 695                 700                 


Leu Arg Gly Leu Val Leu Gly Lys Leu Gly Lys Ala Gly His Lys Ala 
705                 710                 715                 720 


Thr Leu Glu Glu Ala Arg Arg Arg Phe Lys Asp His Val Glu Gly Lys 
                725                 730                 735     


Gln Ile Leu Ser Ala Asp Leu Arg Ser Pro Val Tyr Leu Thr Val Leu 
            740                 745                 750         


Lys His Gly Asp Gly Thr Thr Leu Asp Ile Met Leu Lys Leu His Lys 
        755                 760                 765             


Gln Ala Asp Met Gln Glu Glu Lys Asn Arg Ile Glu Arg Val Leu Gly 
    770                 775                 780                 


Ala Thr Leu Leu Pro Asp Leu Ile Gln Lys Val Leu Thr Phe Ala Leu 
785                 790                 795                 800 


Ser Glu Glu Val Arg Pro Gln Asp Thr Val Ser Val Ile Gly Gly Val 
                805                 810                 815     


Ala Gly Gly Ser Lys His Gly Arg Lys Ala Ala Trp Lys Phe Ile Lys 
            820                 825                 830         


Asp Asn Trp Glu Glu Leu Tyr Asn Arg Tyr Gln Gly Gly Phe Leu Ile 
        835                 840                 845             


Ser Arg Leu Ile Lys Leu Ser Val Glu Gly Phe Ala Val Asp Lys Met 
    850                 855                 860                 


Ala Gly Glu Val Lys Ala Phe Phe Glu Ser His Pro Ala Pro Ser Ala 
865                 870                 875                 880 


Glu Arg Thr Ile Gln Gln Cys Cys Glu Asn Ile Leu Leu Asn Ala Ala 
                885                 890                 895     


Trp Leu Lys Arg Asp Ala Glu Ser Ile His Gln Tyr Leu Leu Gln Arg 
            900                 905                 910         


Lys Ala Ser Pro Pro Thr Val 
        915                 


<210>  261
<211>  2601
<212>  DNA
<213>  Homo sapiens

<400>  261
ccgcccttgt aggctgtcca cctcaaacgg gccggacagg atatataaga gagaatgcac       60

cgtgcactac acacgcgact cccacaaggt tgcagccgga gccgcccagc tcaccgagag      120

cctagttccg gccagggtcg ccccggcaac cacgagccca gccaatcagc gccccggact      180

gcaccagagc catggtcggc agaagagcac tgatcgtact ggctcactca gagaggacgt      240

ccttcaacta tgccatgaag gaggctgctg cagcggcttt gaagaagaaa ggatgggagg      300

tggtggagtc ggacctctat gccatgaact tcaatcccat catttccaga aaggacatca      360

caggtaaact gaaggaccct gcgaactttc agtatcctgc cgagtctgtt ctggcttata      420

aagaaggcca tctgagccca gatattgtgg ctgaacaaaa gaagctggaa gccgcagacc      480

ttgtgatatt ccagttcccc ctgcagtggt ttggagtccc tgccattctg aaaggctggt      540

ttgagcgagt gttcatagga gagtttgctt acacttacgc tgccatgtat gacaaaggac      600

ccttccggag taagaaggca gtgctttcca tcaccactgg tggcagtggc tccatgtact      660

ctctgcaagg gatccacggg gacatgaatg tcattctctg gccaattcag agtggcattc      720

tgcatttctg tggcttccaa gtcttagaac ctcaactgac atatagcatt gggcacactc      780

cagcagacgc ccgaattcaa atcctggaag gatggaagaa acgcctggag aatatttggg      840

atgagacacc actgtatttt gctccaagca gcctctttga cctaaacttc caggcaggat      900

tcttaatgaa aaaagaggta caggatgagg agaaaaacaa gaaatttggc ctttctgtgg      960

gccatcactt gggcaagtcc atcccaactg acaaccagat caaagctaga aaatgagatt     1020

ccttagcctg gatttccttc taacatgtta tcaaatctgg gtatctttcc aggcttccct     1080

gacttgcttt agtttttaag atttgtgttt ttctttttcc acaaggaata aatgagaggg     1140

aatcgactgt attcgtgcat ttttggatca tttttaactg attcttatga ttactatcat     1200

ggcatataac caaaatccga ctgggctcaa gaggccactt agggaaagat gtagaaagat     1260

gctagaaaaa tgttctttaa aggcatctac acaatttaat tcctcttttt agggctaaag     1320

ttttagggta cagtttggct aggtatcatt caactctcca atgttctatt aatcacctct     1380

ctgtagttta tggcagaagg gaattgctca gagaaggaaa agactgaatc tacctgccct     1440

aagggactta acttgtttgg tagttagcca tctaatgctt gtttatgata tttcttgctt     1500

tcaattacaa agcagttact aatatgccta gcacaagtac cactcttggt cagcttttgt     1560

tgtttatata cagtacacag ataccttgaa aggaagagct aataaatctc ttctttgctg     1620

cagtcatcta cttttttttt aattaaaaaa aatttttttt tgaagcagtc ttgctctgtt     1680

acccaggctg gagtgcagtg gtgtgatctc ggctcactgc aacctctgcc tcccaggttc     1740

cagcaattct cctgcctcag cctccctagt agctgggatg acaggcgcct gccatcatgc     1800

ctgactaatt tttgtatttt tagtagagac ggcgtttcac catgttggcc aggctggtct     1860

caaactcctg acctcaggtg atccgcctac ctcagcctcc caaagtgctg ggattacagg     1920

cgtgatccac cacacctggc ccttgcaatc ttctacttta aggtttgcag agataaacca     1980

ataaatccac accgtacatc tgcaatatga attcaagaaa ggaaatagta ccttcaatac     2040

ttaaaaatag tcttccacaa aaaatacttt atttctgatc tatacaaatt ttcagaaggt     2100

tattttcttt atcattgcta aactgatgac ttactatggg atggggtcca gtcccatgac     2160

cttggggtac aattgtaaac ctagagtttt atcaactttg gtgaacagtt ttggcataat     2220

agtcaatttc tacttctgga agtcatctca ttccactgtt ggtattatat aattcaagga     2280

gaatatgata aaacactgcc ctcttgtggt gcattgaaag aagagatgag aaatgatgaa     2340

aaggttgcct gaaaaatggg agacagcctc ttacttgcca agaaaatgaa gggattggac     2400

cgagctggaa aacctccttt accagatgct gactggcact ggtggttttt gctctcgaca     2460

gtatccacaa tagctgacgg ctgggtgttt cagtttgaaa atattttgtt gccttcatct     2520

tcactgcaat tttgtgtaaa tttctcaaag atctgaatta aataaataaa attcatttct     2580

acagacccac aaaaaaaaaa a                                               2601


<210>  262
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr 
        115                 120                 125             


Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys Lys Ala Val 
    130                 135                 140                 


Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly 
145                 150                 155                 160 


Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln Ser Gly Ile 
                165                 170                 175     


Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser 
            180                 185                 190         


Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp 
        195                 200                 205             


Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala 
    210                 215                 220                 


Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys 
225                 230                 235                 240 


Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val 
                245                 250                 255     


Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala 
            260                 265                 270         


Arg Lys 
        


<210>  263
<211>  2499
<212>  DNA
<213>  Homo sapiens

<400>  263
ccgcccttgt aggctgtcca cctcaaacgg gccggacagg atatataaga gagaatgcac       60

cgtgcactac acacgcgact cccacaaggt tgcagccgga gccgcccagc tcaccgagag      120

cctagttccg gccagggtcg ccccggcaac cacgagccca gccaatcagc gccccggact      180

gcaccagagc catggtcggc agaagagcac tgatcgtact ggctcactca gagaggacgt      240

ccttcaacta tgccatgaag gaggctgctg cagcggcttt gaagaagaaa ggatgggagg      300

tggtggagtc ggacctctat gccatgaact tcaatcccat catttccaga aaggacatca      360

caggtaaact gaaggaccct gcgaactttc agtatcctgc cgagtctgtt ctggcttata      420

aagaaggcca tctgagccca gatattgtgg ctgaacaaaa gaagctggaa gccgcagacc      480

ttgtgatatt ccagttcccc ctgcagtggt ttggagtccc tgccattctg aaaggctggt      540

ttgagcgagt gttcatagga gagtttgctt acacttacgc tgccatgtat gacaaaggac      600

ccttccggag tggcattctg catttctgtg gcttccaagt cttagaacct caactgacat      660

atagcattgg gcacactcca gcagacgccc gaattcaaat cctggaagga tggaagaaac      720

gcctggagaa tatttgggat gagacaccac tgtattttgc tccaagcagc ctctttgacc      780

taaacttcca ggcaggattc ttaatgaaaa aagaggtaca ggatgaggag aaaaacaaga      840

aatttggcct ttctgtgggc catcacttgg gcaagtccat cccaactgac aaccagatca      900

aagctagaaa atgagattcc ttagcctgga tttccttcta acatgttatc aaatctgggt      960

atctttccag gcttccctga cttgctttag tttttaagat ttgtgttttt ctttttccac     1020

aaggaataaa tgagagggaa tcgactgtat tcgtgcattt ttggatcatt tttaactgat     1080

tcttatgatt actatcatgg catataacca aaatccgact gggctcaaga ggccacttag     1140

ggaaagatgt agaaagatgc tagaaaaatg ttctttaaag gcatctacac aatttaattc     1200

ctctttttag ggctaaagtt ttagggtaca gtttggctag gtatcattca actctccaat     1260

gttctattaa tcacctctct gtagtttatg gcagaaggga attgctcaga gaaggaaaag     1320

actgaatcta cctgccctaa gggacttaac ttgtttggta gttagccatc taatgcttgt     1380

ttatgatatt tcttgctttc aattacaaag cagttactaa tatgcctagc acaagtacca     1440

ctcttggtca gcttttgttg tttatataca gtacacagat accttgaaag gaagagctaa     1500

taaatctctt ctttgctgca gtcatctact ttttttttaa ttaaaaaaaa tttttttttg     1560

aagcagtctt gctctgttac ccaggctgga gtgcagtggt gtgatctcgg ctcactgcaa     1620

cctctgcctc ccaggttcca gcaattctcc tgcctcagcc tccctagtag ctgggatgac     1680

aggcgcctgc catcatgcct gactaatttt tgtattttta gtagagacgg cgtttcacca     1740

tgttggccag gctggtctca aactcctgac ctcaggtgat ccgcctacct cagcctccca     1800

aagtgctggg attacaggcg tgatccacca cacctggccc ttgcaatctt ctactttaag     1860

gtttgcagag ataaaccaat aaatccacac cgtacatctg caatatgaat tcaagaaagg     1920

aaatagtacc ttcaatactt aaaaatagtc ttccacaaaa aatactttat ttctgatcta     1980

tacaaatttt cagaaggtta ttttctttat cattgctaaa ctgatgactt actatgggat     2040

ggggtccagt cccatgacct tggggtacaa ttgtaaacct agagttttat caactttggt     2100

gaacagtttt ggcataatag tcaatttcta cttctggaag tcatctcatt ccactgttgg     2160

tattatataa ttcaaggaga atatgataaa acactgccct cttgtggtgc attgaaagaa     2220

gagatgagaa atgatgaaaa ggttgcctga aaaatgggag acagcctctt acttgccaag     2280

aaaatgaagg gattggaccg agctggaaaa cctcctttac cagatgctga ctggcactgg     2340

tggtttttgc tctcgacagt atccacaata gctgacggct gggtgtttca gtttgaaaat     2400

attttgttgc cttcatcttc actgcaattt tgtgtaaatt tctcaaagat ctgaattaaa     2460

taaataaaat tcatttctac agacccacaa aaaaaaaaa                            2499


<210>  264
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr 
        115                 120                 125             


Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Gly Ile Leu His 
    130                 135                 140                 


Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser Ile Gly 
145                 150                 155                 160 


His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp Lys Lys 
                165                 170                 175     


Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala Pro Ser 
            180                 185                 190         


Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys Lys Glu 
        195                 200                 205             


Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val Gly His 
    210                 215                 220                 


His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala Arg Lys 
225                 230                 235                 240 


<210>  265
<211>  2487
<212>  DNA
<213>  Homo sapiens

<400>  265
ccgcccttgt aggctgtcca cctcaaacgg gccggacagg atatataaga gagaatgcac       60

cgtgcactac acacgcgact cccacaaggt tgcagccgga gccgcccagc tcaccgagag      120

cctagttccg gccagggtcg ccccggcaac cacgagccca gccaatcagc gccccggact      180

gcaccagagc catggtcggc agaagagcac tgatcgtact ggctcactca gagaggacgt      240

ccttcaacta tgccatgaag gaggctgctg cagcggcttt gaagaagaaa ggatgggagg      300

tggtggagtc ggacctctat gccatgaact tcaatcccat catttccaga aaggacatca      360

caggtaaact gaaggaccct gcgaactttc agtatcctgc cgagtctgtt ctggcttata      420

aagaaggcca tctgagccca gatattgtgg ctgaacaaaa gaagctggaa gccgcagacc      480

ttgtgatatt ccagagtaag aaggcagtgc tttccatcac cactggtggc agtggctcca      540

tgtactctct gcaagggatc cacggggaca tgaatgtcat tctctggcca attcagagtg      600

gcattctgca tttctgtggc ttccaagtct tagaacctca actgacatat agcattgggc      660

acactccagc agacgcccga attcaaatcc tggaaggatg gaagaaacgc ctggagaata      720

tttgggatga gacaccactg tattttgctc caagcagcct ctttgaccta aacttccagg      780

caggattctt aatgaaaaaa gaggtacagg atgaggagaa aaacaagaaa tttggccttt      840

ctgtgggcca tcacttgggc aagtccatcc caactgacaa ccagatcaaa gctagaaaat      900

gagattcctt agcctggatt tccttctaac atgttatcaa atctgggtat ctttccaggc      960

ttccctgact tgctttagtt tttaagattt gtgtttttct ttttccacaa ggaataaatg     1020

agagggaatc gactgtattc gtgcattttt ggatcatttt taactgattc ttatgattac     1080

tatcatggca tataaccaaa atccgactgg gctcaagagg ccacttaggg aaagatgtag     1140

aaagatgcta gaaaaatgtt ctttaaaggc atctacacaa tttaattcct ctttttaggg     1200

ctaaagtttt agggtacagt ttggctaggt atcattcaac tctccaatgt tctattaatc     1260

acctctctgt agtttatggc agaagggaat tgctcagaga aggaaaagac tgaatctacc     1320

tgccctaagg gacttaactt gtttggtagt tagccatcta atgcttgttt atgatatttc     1380

ttgctttcaa ttacaaagca gttactaata tgcctagcac aagtaccact cttggtcagc     1440

ttttgttgtt tatatacagt acacagatac cttgaaagga agagctaata aatctcttct     1500

ttgctgcagt catctacttt ttttttaatt aaaaaaaatt tttttttgaa gcagtcttgc     1560

tctgttaccc aggctggagt gcagtggtgt gatctcggct cactgcaacc tctgcctccc     1620

aggttccagc aattctcctg cctcagcctc cctagtagct gggatgacag gcgcctgcca     1680

tcatgcctga ctaatttttg tatttttagt agagacggcg tttcaccatg ttggccaggc     1740

tggtctcaaa ctcctgacct caggtgatcc gcctacctca gcctcccaaa gtgctgggat     1800

tacaggcgtg atccaccaca cctggccctt gcaatcttct actttaaggt ttgcagagat     1860

aaaccaataa atccacaccg tacatctgca atatgaattc aagaaaggaa atagtacctt     1920

caatacttaa aaatagtctt ccacaaaaaa tactttattt ctgatctata caaattttca     1980

gaaggttatt ttctttatca ttgctaaact gatgacttac tatgggatgg ggtccagtcc     2040

catgaccttg gggtacaatt gtaaacctag agttttatca actttggtga acagttttgg     2100

cataatagtc aatttctact tctggaagtc atctcattcc actgttggta ttatataatt     2160

caaggagaat atgataaaac actgccctct tgtggtgcat tgaaagaaga gatgagaaat     2220

gatgaaaagg ttgcctgaaa aatgggagac agcctcttac ttgccaagaa aatgaaggga     2280

ttggaccgag ctggaaaacc tcctttacca gatgctgact ggcactggtg gtttttgctc     2340

tcgacagtat ccacaatagc tgacggctgg gtgtttcagt ttgaaaatat tttgttgcct     2400

tcatcttcac tgcaattttg tgtaaatttc tcaaagatct gaattaaata aataaaattc     2460

atttctacag acccacaaaa aaaaaaa                                         2487


<210>  266
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Ser Lys Lys Ala Val Leu Ser Ile Thr Thr Gly 
            100                 105                 110         


Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly Ile His Gly Asp Met Asn 
        115                 120                 125             


Val Ile Leu Trp Pro Ile Gln Ser Gly Ile Leu His Phe Cys Gly Phe 
    130                 135                 140                 


Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser Ile Gly His Thr Pro Ala 
145                 150                 155                 160 


Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp Lys Lys Arg Leu Glu Asn 
                165                 170                 175     


Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala Pro Ser Ser Leu Phe Asp 
            180                 185                 190         


Leu Asn Phe Gln Ala Gly Phe Leu Met Lys Lys Glu Val Gln Asp Glu 
        195                 200                 205             


Glu Lys Asn Lys Lys Phe Gly Leu Ser Val Gly His His Leu Gly Lys 
    210                 215                 220                 


Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala Arg Lys 
225                 230                 235     


<210>  267
<211>  3443
<212>  DNA
<213>  Homo sapiens

<400>  267
gtgctttact gcgcgctctg gtactgctgt ggctccccgt cctggtgcgg gacctgtgcc       60

ccgcgcttca gccctccccg cacagcctac tgattcccct gccgcccttg ctcacctcct      120

gctcgccatg gagtcgctgg ttttcgcgcg gcgctccggc cccactccct cggccgcaga      180

gctagcccgg ccgctggcgg aagggctgat caagtcgccc aagcccctaa tgaagaagca      240

ggcggtgaag cggcaccacc acaagcacaa cctgcggcac cgctacgagt tcctggagac      300

cctgggcaaa ggcacctacg ggaaggtgaa gaaggcgcgg gagagctcgg ggcgcctggt      360

ggccatcaag tcaatccgga aggacaaaat caaagatgag caagatctga tgcacatacg      420

gagggagatt gagatcatgt catcactcaa ccaccctcac atcattgcca tccatgaagt      480

gtttgagaac agcagcaaga tcgtgatcgt catggagtat gccagccggg gcgaccttta      540

tgactacatc agcgagcggc agcagctcag tgagcgcgaa gctaggcatt tcttccggca      600

gatcgtctct gccgtgcact attgccatca gaacagagtt gtccaccgag atctcaagct      660

ggagaacatc ctcttggatg ccaatgggaa tatcaagatt gctgacttcg gcctctccaa      720

cctctaccat caaggcaagt tcctgcagac attctgtggg agccccctct atgcctcgcc      780

agagattgtc aatgggaagc cctacacagg cccagaggtg gacagctggt ccctgggtgt      840

tctcctctac atcctggtgc atggcaccat gccctttgat gggcatgacc ataagatcct      900

agtgaaacag atcagcaacg gggcctaccg ggagccacct aaaccctctg atgcctgtgg      960

cctgatccgg tggctgttga tggtgaaccc cacccgccgg gccaccctgg aggatgtggc     1020

cagtcactgg tgggtcaact ggggctacgc cacccgagtg ggagagcagg aggctccgca     1080

tgagggtggg caccctggca gtgactctgc ccgcgcctcc atggctgact ggctccggcg     1140

ttcctcccgc cccctcctgg agaatggggc caaggtgtgc agcttcttca agcagcatgc     1200

acctggtggg ggaagcacca cccctggcct ggagcgccag cattcgctca agaagtcccg     1260

caaggagaat gacatggccc agtctctcca cagtgacacg gctgatgaca ctgcccatcg     1320

ccctggcaag agcaacctca agctgccaaa gggcattctc aagaagaagg tgtcagcctc     1380

tgcagaaggg gtacaggagg accctccgga gctcagccca atccctgcga gcccagggca     1440

ggctgccccg ctgctcccca agaagggcat tctcaagaag ccccgacagc gcgagtctgg     1500

ctactactcc tctcccgagc ccagtgaatc tggggagctc ttggacgcag gcgacgtgtt     1560

tgtgagtggg gatcccaagg agcagaagcc tccgcaagct tcagggctgc tcctccatcg     1620

caaaggcatc ctcaaactca atggcaagtt ctcccagaca gccttggagc tcgcggcccc     1680

caccaccttc ggctccctgg atgaactcgc cccacctcgc cccctggccc gggccagccg     1740

accctcaggg gctgtgagcg aggacagcat cctgtcctct gagtcctttg accagctgga     1800

cttgcctgaa cggctcccag agcccccact gcggggctgt gtgtctgtgg acaacctcac     1860

ggggcttgag gagcccccct cagagggccc tggaagctgc ctgaggcgct ggcggcagga     1920

tcctttgggg gacagctgct tttccctgac agactgccag gaggtgacag cgacctaccg     1980

acaggcactg agggtctgct caaagctcac ctgagtggag taggcattgc cccagcccgg     2040

tcaggctctc agatgcagct ggttgcaccc cgaggggaga tgccttctcc cccacctccc     2100

aggacctgca tcccagctca gaaggctgag agggtttgca gtggagccct gagcagggct     2160

ggatatggga agtaggcaaa tgaaatgcgc caagggttca gtgtctgtct tcagccctgc     2220

tgaacgaaga ggatactaaa gagaggggaa cgggaatgcc cgcgacagag tccacattgc     2280

ctgtttcttg tgtacatggg ggggccacag agacctggaa agagaactct cccagggccc     2340

atctcctgca tcccatgaat actctgtaca catggtgcct tctaaggaca gctccttccc     2400

tactcattcc ctgcccaagt ggggccagac ctctttacac acacattccc gttcctacca     2460

accaccagaa ctggatggtg gcacccctaa tgtgcatgag gcatcctggg aatggtctgg     2520

agtaacgctt cgttattttt atttttattt ttatttattt atttattttt ttgagacgga     2580

gtttcgctct tggtgcccag gctagagtgc aatggcgcga tctcagctca cctcaacctc     2640

cgcctcccgg gttcaagcga ttctcctgcc tcagcctccc tagtagctgg gattacaggc     2700

gcccgccacc atgcccggct aattttgtat ttttagtaga gacagggttt ctccatgttg     2760

gtcaggctgg tctcaaactc ccgacctcag gtgatccacc cacctcggcc tcccaaagtg     2820

ctgggattac aggcgtgagc caccgcgccc cacctaaccc ttccttattt agcctaggag     2880

taagagaaca caatctctgt ttcttcaatg gttctcttcc cttttccatc ctccaaacct     2940

ggcctgagcc tcctgaagtt gctgctgtga atctgaaaga cttgaaaagc ctccgcctgc     3000

tgtgtggact tcatctcaag gggcccagcc tcctctggac tccaccttgg acctcagtga     3060

ctcagaactt ctgcctctaa gctgctctaa agtccagact atggatgtgt tctctaggcc     3120

ttcaggactc tagaatgtcc atatttattt ttatgttctt ggctttgtgt tttaggaaaa     3180

gtgaatcttg ctgttttcaa taatgtgaat gctatgttct gggaaaatcc actatgacat     3240

ctaagttttg tgtacagaga gatatttttg caactatttc cacctcctcc cacaaccccc     3300

cacactccac tccacactct tgagtctctt tacctaatgg tctctaccta atggacctcc     3360

gtggccaaaa agtaccatta aaaccagaaa ggtgattgga aaaaaaaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaa                                             3443


<210>  268
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Glu Ser Leu Val Phe Ala Arg Arg Ser Gly Pro Thr Pro Ser Ala 
1               5                   10                  15      


Ala Glu Leu Ala Arg Pro Leu Ala Glu Gly Leu Ile Lys Ser Pro Lys 
            20                  25                  30          


Pro Leu Met Lys Lys Gln Ala Val Lys Arg His His His Lys His Asn 
        35                  40                  45              


Leu Arg His Arg Tyr Glu Phe Leu Glu Thr Leu Gly Lys Gly Thr Tyr 
    50                  55                  60                  


Gly Lys Val Lys Lys Ala Arg Glu Ser Ser Gly Arg Leu Val Ala Ile 
65                  70                  75                  80  


Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp Leu Met His 
                85                  90                  95      


Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His Pro His Ile 
            100                 105                 110         


Ile Ala Ile His Glu Val Phe Glu Asn Ser Ser Lys Ile Val Ile Val 
        115                 120                 125             


Met Glu Tyr Ala Ser Arg Gly Asp Leu Tyr Asp Tyr Ile Ser Glu Arg 
    130                 135                 140                 


Gln Gln Leu Ser Glu Arg Glu Ala Arg His Phe Phe Arg Gln Ile Val 
145                 150                 155                 160 


Ser Ala Val His Tyr Cys His Gln Asn Arg Val Val His Arg Asp Leu 
                165                 170                 175     


Lys Leu Glu Asn Ile Leu Leu Asp Ala Asn Gly Asn Ile Lys Ile Ala 
            180                 185                 190         


Asp Phe Gly Leu Ser Asn Leu Tyr His Gln Gly Lys Phe Leu Gln Thr 
        195                 200                 205             


Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val Asn Gly Lys 
    210                 215                 220                 


Pro Tyr Thr Gly Pro Glu Val Asp Ser Trp Ser Leu Gly Val Leu Leu 
225                 230                 235                 240 


Tyr Ile Leu Val His Gly Thr Met Pro Phe Asp Gly His Asp His Lys 
                245                 250                 255     


Ile Leu Val Lys Gln Ile Ser Asn Gly Ala Tyr Arg Glu Pro Pro Lys 
            260                 265                 270         


Pro Ser Asp Ala Cys Gly Leu Ile Arg Trp Leu Leu Met Val Asn Pro 
        275                 280                 285             


Thr Arg Arg Ala Thr Leu Glu Asp Val Ala Ser His Trp Trp Val Asn 
    290                 295                 300                 


Trp Gly Tyr Ala Thr Arg Val Gly Glu Gln Glu Ala Pro His Glu Gly 
305                 310                 315                 320 


Gly His Pro Gly Ser Asp Ser Ala Arg Ala Ser Met Ala Asp Trp Leu 
                325                 330                 335     


Arg Arg Ser Ser Arg Pro Leu Leu Glu Asn Gly Ala Lys Val Cys Ser 
            340                 345                 350         


Phe Phe Lys Gln His Ala Pro Gly Gly Gly Ser Thr Thr Pro Gly Leu 
        355                 360                 365             


Glu Arg Gln His Ser Leu Lys Lys Ser Arg Lys Glu Asn Asp Met Ala 
    370                 375                 380                 


Gln Ser Leu His Ser Asp Thr Ala Asp Asp Thr Ala His Arg Pro Gly 
385                 390                 395                 400 


Lys Ser Asn Leu Lys Leu Pro Lys Gly Ile Leu Lys Lys Lys Val Ser 
                405                 410                 415     


Ala Ser Ala Glu Gly Val Gln Glu Asp Pro Pro Glu Leu Ser Pro Ile 
            420                 425                 430         


Pro Ala Ser Pro Gly Gln Ala Ala Pro Leu Leu Pro Lys Lys Gly Ile 
        435                 440                 445             


Leu Lys Lys Pro Arg Gln Arg Glu Ser Gly Tyr Tyr Ser Ser Pro Glu 
    450                 455                 460                 


Pro Ser Glu Ser Gly Glu Leu Leu Asp Ala Gly Asp Val Phe Val Ser 
465                 470                 475                 480 


Gly Asp Pro Lys Glu Gln Lys Pro Pro Gln Ala Ser Gly Leu Leu Leu 
                485                 490                 495     


His Arg Lys Gly Ile Leu Lys Leu Asn Gly Lys Phe Ser Gln Thr Ala 
            500                 505                 510         


Leu Glu Leu Ala Ala Pro Thr Thr Phe Gly Ser Leu Asp Glu Leu Ala 
        515                 520                 525             


Pro Pro Arg Pro Leu Ala Arg Ala Ser Arg Pro Ser Gly Ala Val Ser 
    530                 535                 540                 


Glu Asp Ser Ile Leu Ser Ser Glu Ser Phe Asp Gln Leu Asp Leu Pro 
545                 550                 555                 560 


Glu Arg Leu Pro Glu Pro Pro Leu Arg Gly Cys Val Ser Val Asp Asn 
                565                 570                 575     


Leu Thr Gly Leu Glu Glu Pro Pro Ser Glu Gly Pro Gly Ser Cys Leu 
            580                 585                 590         


Arg Arg Trp Arg Gln Asp Pro Leu Gly Asp Ser Cys Phe Ser Leu Thr 
        595                 600                 605             


Asp Cys Gln Glu Val Thr Ala Thr Tyr Arg Gln Ala Leu Arg Val Cys 
    610                 615                 620                 


Ser Lys Leu Thr 
625             


<210>  269
<211>  4065
<212>  DNA
<213>  Homo sapiens

<400>  269
gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc       60

aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg      120

ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc      180

catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc      240

tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg      300

cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta      360

ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac      420

ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg      480

ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt      540

cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga      600

cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt      660

aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct      720

cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag      780

ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac      840

ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta      900

cccagaggcc tatgcctccc ccagccacac caaaggcgag cagggcctct acccgctgcc      960

cttgctcaac agcaccctgg acgacgggaa ggccaccctg accccttcca acacgccact     1020

ggggcgcaac ctctcgactc accagaccta ccccgtggtg gcagatcctc actcaccctt     1080

cgccataaag caggaaaccc ccgaggtgtc cagttctagc tccacccctt cctctttatc     1140

tagctccgcc tttttggatc tgcagcaagt cggctccggg gtcccgccct tcaatgcctt     1200

tccccatgct gcctccgtgt acgggcagtt cacgggccag gccctcctct cagggcgaga     1260

gatggtgggg cccacgctgc ccggataccc accccacatc cccaccagcg gacagggcag     1320

ctatgcctcc tctgccatcg caggcatggt ggcaggaagt gaatactctg gcaatgccta     1380

tggccacacc ccctactcct cctacagcga ggcctggcgc ttccccaact ccagcttgct     1440

gagttcccca tattattaca gttccacatc aaggccgagt gcaccgccca ccactgccac     1500

ggcctttgac catctgtagt tgccatgggg acagtgggag cgactgagca acaggaggac     1560

tcagcctggg acaggcccca gagagtcaca caaaggaatc tttatttatt acatgaaaaa     1620

taaccacaag tccagcattg cggcacactc cctgtgtggt taatttaatg aaccatgaaa     1680

gacaggatga ccttggacaa ggccaaactg tcctccaaga ctccttaatg aggggcagga     1740

gtcccaggga aagagaacca tgccatgctg aaaaagacaa aattgaagaa gaaatgtagc     1800

ccccagccgg tacccaccaa aggagagaag aagcaatagc cgaggaactt ggggggatgg     1860

cgaatggttc ctgcccgggc ccaaggggtg cacagggcac ctccatggct ccattattaa     1920

cacaactcta gcaattatgg accataagca cttccctcca gcccacaagt cacagcctgg     1980

tgccgaggct ctcctcacca gccacccagg gagtcacctc cctcagcctc ccgcctgccc     2040

cacacggagg ctctggctgt cctctttctc cactccattt gcttggctct ttctacacct     2100

ccctcttggg catgggctga gggctggagc gagtccctca gaaattccac caggctgtca     2160

gctgacctct tttgcctgct gctgtgaagg tatagcacca ccccaggtcc tcctgcagtg     2220

cggcatcccc ttggcagctg ccgtcagcca ggccagcccc agggagctta aaacagacat     2280

tccacagggc ctgggcccct gggaggtgag gtgtggtgtg cggcttcacc cagggcagaa     2340

caaggcagaa tcgcaggaaa cccgcttccc cttcctgaca gctcctgcca agccaaatgt     2400

gcttcctgca gctcacgccc accagctact gaagggaccc aaggcacccc ctgaagccag     2460

cgatagaggg tccctctctg ctccccagca gctcctgccc ccaaggcctg actgtatata     2520

ctgtaaatga aactttgttt gggtcaagct tccttctttc taacccccag actttggcct     2580

ctgagtgaaa tgtctctctt tgccctgtgg ggcttctctc cttgatgctt ctttcttttt     2640

ttaaagacaa cctgccatta ccacatgact caataaacca ttgctcttca tctcaggctt     2700

tggggttggc tggggaagga ggcatcccgg ggctgggctt tctcccaaga acatcagagc     2760

tgagtagccg acaaactcac tttggggccg tgggctggaa gggaccatct gatgccccag     2820

agctctggct tggccttctc cctctgcctt taattcacgt tgaacgctgg gtacctcact     2880

catcccaagt tcttcaacac tgagcaaatg caaggatagc acagtactga gccaaccata     2940

gactccccac aaggagttgc tgttgttatt aacaggaagc cagagaatca gcagggtggg     3000

ttagtgaggg atccgggaat agctgtgact ggagcctgca taaacagctc tgaagggaga     3060

gagaagactg ggctctcttg tgtgccaggc acagtatgga aggcttcata taagttaagc     3120

tgaaattagc cctgttttac atacagcttc attttacata tgaggaaact gaggctttga     3180

aaaaaatgag atgtcttgtc caagatgaaa agtagtagat tcaaccaagt cctcttactc     3240

taagcccaac gcttttaccc aaaaccccag agtcctcatc agggatgcca aatggttcta     3300

gacccagtgg aggttctgga gctgccactg gggatttaat ttcttttgat ttgctaaaga     3360

tttgacctga ctgaatggag aggtagagtg tagtgtggcc aggacaaggt gagggaggct     3420

gtagagactt agcactttag gccaaccacc tccaggaaat ctgggaaatg caatgtgaca     3480

gctcgggctc tgcactccag ggggctgtct ggtgtccaca tggaccttct ccatgtggga     3540

cacagctgga acaagggggc aggggcctgc agctgggatg cccaggtgaa tatgggcagc     3600

tggacaaaca acactgggat tgagtcagat agaaggggcc caaggactcc agggctggga     3660

ggacagaggc tgggagagag ggctcttacc tccttaggcc tcccaaagag cggttaggga     3720

tgctgccatg gatggcatgg cagggggaac cctcctggaa gaaaatccat ctcttctgaa     3780

gggatctgag atgcggctgg tttttcaatg gcagaacttc cctctgcagc gcgactccga     3840

atccatgaca tctgagagtc ttcctgacca caaacctctg ggatcccgag ggctccctac     3900

ccaagaatca ctttgagcac agcatcccaa ggagcccata gagcgatccc ttgcattcac     3960

agccacagcc cctctgggga cactctgtac ccccggcaga ccctttccaa ctcacaacca     4020

ataaaggggc ttgggctgtg ctttgactaa ggtgaaaaaa aaaaa                     4065


<210>  270
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr Leu Asp 
            260                 265                 270         


Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly Arg Asn 
        275                 280                 285             


Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Asp Pro His Ser Pro 
    290                 295                 300                 


Phe Ala Ile Lys Gln Glu Thr Pro Glu Val Ser Ser Ser Ser Ser Thr 
305                 310                 315                 320 


Pro Ser Ser Leu Ser Ser Ser Ala Phe Leu Asp Leu Gln Gln Val Gly 
                325                 330                 335     


Ser Gly Val Pro Pro Phe Asn Ala Phe Pro His Ala Ala Ser Val Tyr 
            340                 345                 350         


Gly Gln Phe Thr Gly Gln Ala Leu Leu Ser Gly Arg Glu Met Val Gly 
        355                 360                 365             


Pro Thr Leu Pro Gly Tyr Pro Pro His Ile Pro Thr Ser Gly Gln Gly 
    370                 375                 380                 


Ser Tyr Ala Ser Ser Ala Ile Ala Gly Met Val Ala Gly Ser Glu Tyr 
385                 390                 395                 400 


Ser Gly Asn Ala Tyr Gly His Thr Pro Tyr Ser Ser Tyr Ser Glu Ala 
                405                 410                 415     


Trp Arg Phe Pro Asn Ser Ser Leu Leu Ser Ser Pro Tyr Tyr Tyr Ser 
            420                 425                 430         


Ser Thr Ser Arg Pro Ser Ala Pro Pro Thr Thr Ala Thr Ala Phe Asp 
        435                 440                 445             


His Leu 
    450 


<210>  271
<211>  3876
<212>  DNA
<213>  Homo sapiens

<400>  271
gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc       60

aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg      120

ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc      180

catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc      240

tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg      300

cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta      360

ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac      420

ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg      480

ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt      540

cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga      600

cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt      660

aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct      720

cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag      780

ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac      840

ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta      900

cccagaggcc tatgcctccc ccagccacac caaaggcgag cagggcctct acccgctgcc      960

cttgctcaac agcaccctgg acgacgggaa ggccaccctg accccttcca acacgccact     1020

ggggcgcaac ctctcgactc accagaccta ccccgtggtg gcagggcgag agatggtggg     1080

gcccacgctg cccggatacc caccccacat ccccaccagc ggacagggca gctatgcctc     1140

ctctgccatc gcaggcatgg tggcaggaag tgaatactct ggcaatgcct atggccacac     1200

cccctactcc tcctacagcg aggcctggcg cttccccaac tccagcttgc tgagttcccc     1260

atattattac agttccacat caaggccgag tgcaccgccc accactgcca cggcctttga     1320

ccatctgtag ttgccatggg gacagtggga gcgactgagc aacaggagga ctcagcctgg     1380

gacaggcccc agagagtcac acaaaggaat ctttatttat tacatgaaaa ataaccacaa     1440

gtccagcatt gcggcacact ccctgtgtgg ttaatttaat gaaccatgaa agacaggatg     1500

accttggaca aggccaaact gtcctccaag actccttaat gaggggcagg agtcccaggg     1560

aaagagaacc atgccatgct gaaaaagaca aaattgaaga agaaatgtag cccccagccg     1620

gtacccacca aaggagagaa gaagcaatag ccgaggaact tggggggatg gcgaatggtt     1680

cctgcccggg cccaaggggt gcacagggca cctccatggc tccattatta acacaactct     1740

agcaattatg gaccataagc acttccctcc agcccacaag tcacagcctg gtgccgaggc     1800

tctcctcacc agccacccag ggagtcacct ccctcagcct cccgcctgcc ccacacggag     1860

gctctggctg tcctctttct ccactccatt tgcttggctc tttctacacc tccctcttgg     1920

gcatgggctg agggctggag cgagtccctc agaaattcca ccaggctgtc agctgacctc     1980

ttttgcctgc tgctgtgaag gtatagcacc accccaggtc ctcctgcagt gcggcatccc     2040

cttggcagct gccgtcagcc aggccagccc cagggagctt aaaacagaca ttccacaggg     2100

cctgggcccc tgggaggtga ggtgtggtgt gcggcttcac ccagggcaga acaaggcaga     2160

atcgcaggaa acccgcttcc ccttcctgac agctcctgcc aagccaaatg tgcttcctgc     2220

agctcacgcc caccagctac tgaagggacc caaggcaccc cctgaagcca gcgatagagg     2280

gtccctctct gctccccagc agctcctgcc cccaaggcct gactgtatat actgtaaatg     2340

aaactttgtt tgggtcaagc ttccttcttt ctaaccccca gactttggcc tctgagtgaa     2400

atgtctctct ttgccctgtg gggcttctct ccttgatgct tctttctttt tttaaagaca     2460

acctgccatt accacatgac tcaataaacc attgctcttc atctcaggct ttggggttgg     2520

ctggggaagg aggcatcccg gggctgggct ttctcccaag aacatcagag ctgagtagcc     2580

gacaaactca ctttggggcc gtgggctgga agggaccatc tgatgcccca gagctctggc     2640

ttggccttct ccctctgcct ttaattcacg ttgaacgctg ggtacctcac tcatcccaag     2700

ttcttcaaca ctgagcaaat gcaaggatag cacagtactg agccaaccat agactcccca     2760

caaggagttg ctgttgttat taacaggaag ccagagaatc agcagggtgg gttagtgagg     2820

gatccgggaa tagctgtgac tggagcctgc ataaacagct ctgaagggag agagaagact     2880

gggctctctt gtgtgccagg cacagtatgg aaggcttcat ataagttaag ctgaaattag     2940

ccctgtttta catacagctt cattttacat atgaggaaac tgaggctttg aaaaaaatga     3000

gatgtcttgt ccaagatgaa aagtagtaga ttcaaccaag tcctcttact ctaagcccaa     3060

cgcttttacc caaaacccca gagtcctcat cagggatgcc aaatggttct agacccagtg     3120

gaggttctgg agctgccact ggggatttaa tttcttttga tttgctaaag atttgacctg     3180

actgaatgga gaggtagagt gtagtgtggc caggacaagg tgagggaggc tgtagagact     3240

tagcacttta ggccaaccac ctccaggaaa tctgggaaat gcaatgtgac agctcgggct     3300

ctgcactcca gggggctgtc tggtgtccac atggaccttc tccatgtggg acacagctgg     3360

aacaaggggg caggggcctg cagctgggat gcccaggtga atatgggcag ctggacaaac     3420

aacactggga ttgagtcaga tagaaggggc ccaaggactc cagggctggg aggacagagg     3480

ctgggagaga gggctcttac ctccttaggc ctcccaaaga gcggttaggg atgctgccat     3540

ggatggcatg gcagggggaa ccctcctgga agaaaatcca tctcttctga agggatctga     3600

gatgcggctg gtttttcaat ggcagaactt ccctctgcag cgcgactccg aatccatgac     3660

atctgagagt cttcctgacc acaaacctct gggatcccga gggctcccta cccaagaatc     3720

actttgagca cagcatccca aggagcccat agagcgatcc cttgcattca cagccacagc     3780

ccctctgggg acactctgta cccccggcag accctttcca actcacaacc aataaagggg     3840

cttgggctgt gctttgacta aggtgaaaaa aaaaaa                               3876


<210>  272
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr Leu Asp 
            260                 265                 270         


Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly Arg Asn 
        275                 280                 285             


Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Gly Arg Glu Met Val 
    290                 295                 300                 


Gly Pro Thr Leu Pro Gly Tyr Pro Pro His Ile Pro Thr Ser Gly Gln 
305                 310                 315                 320 


Gly Ser Tyr Ala Ser Ser Ala Ile Ala Gly Met Val Ala Gly Ser Glu 
                325                 330                 335     


Tyr Ser Gly Asn Ala Tyr Gly His Thr Pro Tyr Ser Ser Tyr Ser Glu 
            340                 345                 350         


Ala Trp Arg Phe Pro Asn Ser Ser Leu Leu Ser Ser Pro Tyr Tyr Tyr 
        355                 360                 365             


Ser Ser Thr Ser Arg Pro Ser Ala Pro Pro Thr Thr Ala Thr Ala Phe 
    370                 375                 380                 


Asp His Leu 
385         


<210>  273
<211>  3986
<212>  DNA
<213>  Homo sapiens

<400>  273
gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc       60

aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg      120

ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc      180

catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc      240

tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg      300

cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta      360

ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac      420

ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg      480

ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt      540

cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga      600

cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt      660

aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct      720

cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag      780

ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac      840

ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta      900

cccagaggcc tatgcctccc ccagccacac caaaggcgag cagggcctct acccgctgcc      960

cttgctcaac agcaccctgg acgacgggaa ggccaccctg accccttcca acacgccact     1020

ggggcgcaac ctctcgactc accagaccta ccccgtggtg gcagctccgc ctttttggat     1080

ctgcagcaag tcggctccgg ggtcccgccc ttcaatgcct ttccccatgc tgcctccgtg     1140

tacgggcagt tcacgggcca ggccctcctc tcagggcgag agatggtggg gcccacgctg     1200

cccggatacc caccccacat ccccaccagc ggacagggca gctatgcctc ctctgccatc     1260

gcaggcatgg tggcaggaag tgaatactct ggcaatgcct atggccacac cccctactcc     1320

tcctacagcg aggcctggcg cttccccaac tccagcttgc tgagttcccc atattattac     1380

agttccacat caaggccgag tgcaccgccc accactgcca cggcctttga ccatctgtag     1440

ttgccatggg gacagtggga gcgactgagc aacaggagga ctcagcctgg gacaggcccc     1500

agagagtcac acaaaggaat ctttatttat tacatgaaaa ataaccacaa gtccagcatt     1560

gcggcacact ccctgtgtgg ttaatttaat gaaccatgaa agacaggatg accttggaca     1620

aggccaaact gtcctccaag actccttaat gaggggcagg agtcccaggg aaagagaacc     1680

atgccatgct gaaaaagaca aaattgaaga agaaatgtag cccccagccg gtacccacca     1740

aaggagagaa gaagcaatag ccgaggaact tggggggatg gcgaatggtt cctgcccggg     1800

cccaaggggt gcacagggca cctccatggc tccattatta acacaactct agcaattatg     1860

gaccataagc acttccctcc agcccacaag tcacagcctg gtgccgaggc tctcctcacc     1920

agccacccag ggagtcacct ccctcagcct cccgcctgcc ccacacggag gctctggctg     1980

tcctctttct ccactccatt tgcttggctc tttctacacc tccctcttgg gcatgggctg     2040

agggctggag cgagtccctc agaaattcca ccaggctgtc agctgacctc ttttgcctgc     2100

tgctgtgaag gtatagcacc accccaggtc ctcctgcagt gcggcatccc cttggcagct     2160

gccgtcagcc aggccagccc cagggagctt aaaacagaca ttccacaggg cctgggcccc     2220

tgggaggtga ggtgtggtgt gcggcttcac ccagggcaga acaaggcaga atcgcaggaa     2280

acccgcttcc ccttcctgac agctcctgcc aagccaaatg tgcttcctgc agctcacgcc     2340

caccagctac tgaagggacc caaggcaccc cctgaagcca gcgatagagg gtccctctct     2400

gctccccagc agctcctgcc cccaaggcct gactgtatat actgtaaatg aaactttgtt     2460

tgggtcaagc ttccttcttt ctaaccccca gactttggcc tctgagtgaa atgtctctct     2520

ttgccctgtg gggcttctct ccttgatgct tctttctttt tttaaagaca acctgccatt     2580

accacatgac tcaataaacc attgctcttc atctcaggct ttggggttgg ctggggaagg     2640

aggcatcccg gggctgggct ttctcccaag aacatcagag ctgagtagcc gacaaactca     2700

ctttggggcc gtgggctgga agggaccatc tgatgcccca gagctctggc ttggccttct     2760

ccctctgcct ttaattcacg ttgaacgctg ggtacctcac tcatcccaag ttcttcaaca     2820

ctgagcaaat gcaaggatag cacagtactg agccaaccat agactcccca caaggagttg     2880

ctgttgttat taacaggaag ccagagaatc agcagggtgg gttagtgagg gatccgggaa     2940

tagctgtgac tggagcctgc ataaacagct ctgaagggag agagaagact gggctctctt     3000

gtgtgccagg cacagtatgg aaggcttcat ataagttaag ctgaaattag ccctgtttta     3060

catacagctt cattttacat atgaggaaac tgaggctttg aaaaaaatga gatgtcttgt     3120

ccaagatgaa aagtagtaga ttcaaccaag tcctcttact ctaagcccaa cgcttttacc     3180

caaaacccca gagtcctcat cagggatgcc aaatggttct agacccagtg gaggttctgg     3240

agctgccact ggggatttaa tttcttttga tttgctaaag atttgacctg actgaatgga     3300

gaggtagagt gtagtgtggc caggacaagg tgagggaggc tgtagagact tagcacttta     3360

ggccaaccac ctccaggaaa tctgggaaat gcaatgtgac agctcgggct ctgcactcca     3420

gggggctgtc tggtgtccac atggaccttc tccatgtggg acacagctgg aacaaggggg     3480

caggggcctg cagctgggat gcccaggtga atatgggcag ctggacaaac aacactggga     3540

ttgagtcaga tagaaggggc ccaaggactc cagggctggg aggacagagg ctgggagaga     3600

gggctcttac ctccttaggc ctcccaaaga gcggttaggg atgctgccat ggatggcatg     3660

gcagggggaa ccctcctgga agaaaatcca tctcttctga agggatctga gatgcggctg     3720

gtttttcaat ggcagaactt ccctctgcag cgcgactccg aatccatgac atctgagagt     3780

cttcctgacc acaaacctct gggatcccga gggctcccta cccaagaatc actttgagca     3840

cagcatccca aggagcccat agagcgatcc cttgcattca cagccacagc ccctctgggg     3900

acactctgta cccccggcag accctttcca actcacaacc aataaagggg cttgggctgt     3960

gctttgacta aggtgaaaaa aaaaaa                                          3986


<210>  274
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr Leu Asp 
            260                 265                 270         


Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly Arg Asn 
        275                 280                 285             


Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Ala Pro Pro Phe Trp 
    290                 295                 300                 


Ile Cys Ser Lys Ser Ala Pro Gly Ser Arg Pro Ser Met Pro Phe Pro 
305                 310                 315                 320 


Met Leu Pro Pro Cys Thr Gly Ser Ser Arg Ala Arg Pro Ser Ser Gln 
                325                 330                 335     


Gly Glu Arg Trp Trp Gly Pro Arg Cys Pro Asp Thr His Pro Thr Ser 
            340                 345                 350         


Pro Pro Ala Asp Arg Ala Ala Met Pro Pro Leu Pro Ser Gln Ala Trp 
        355                 360                 365             


Trp Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr Pro Pro Thr 
    370                 375                 380                 


Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala Cys 
385                 390                 395             


<210>  275
<211>  3755
<212>  DNA
<213>  Homo sapiens

<400>  275
gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc       60

aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg      120

ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc      180

catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc      240

tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg      300

cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta      360

ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac      420

ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg      480

ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt      540

cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga      600

cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt      660

aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct      720

cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag      780

ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac      840

ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta      900

cccagaggcc tatgcctccc ccagccacac caaaggcgag cagggcgaga gatggtgggg      960

cccacgctgc ccggataccc accccacatc cccaccagcg gacagggcag ctatgcctcc     1020

tctgccatcg caggcatggt ggcaggaagt gaatactctg gcaatgccta tggccacacc     1080

ccctactcct cctacagcga ggcctggcgc ttccccaact ccagcttgct gagttcccca     1140

tattattaca gttccacatc aaggccgagt gcaccgccca ccactgccac ggcctttgac     1200

catctgtagt tgccatgggg acagtgggag cgactgagca acaggaggac tcagcctggg     1260

acaggcccca gagagtcaca caaaggaatc tttatttatt acatgaaaaa taaccacaag     1320

tccagcattg cggcacactc cctgtgtggt taatttaatg aaccatgaaa gacaggatga     1380

ccttggacaa ggccaaactg tcctccaaga ctccttaatg aggggcagga gtcccaggga     1440

aagagaacca tgccatgctg aaaaagacaa aattgaagaa gaaatgtagc ccccagccgg     1500

tacccaccaa aggagagaag aagcaatagc cgaggaactt ggggggatgg cgaatggttc     1560

ctgcccgggc ccaaggggtg cacagggcac ctccatggct ccattattaa cacaactcta     1620

gcaattatgg accataagca cttccctcca gcccacaagt cacagcctgg tgccgaggct     1680

ctcctcacca gccacccagg gagtcacctc cctcagcctc ccgcctgccc cacacggagg     1740

ctctggctgt cctctttctc cactccattt gcttggctct ttctacacct ccctcttggg     1800

catgggctga gggctggagc gagtccctca gaaattccac caggctgtca gctgacctct     1860

tttgcctgct gctgtgaagg tatagcacca ccccaggtcc tcctgcagtg cggcatcccc     1920

ttggcagctg ccgtcagcca ggccagcccc agggagctta aaacagacat tccacagggc     1980

ctgggcccct gggaggtgag gtgtggtgtg cggcttcacc cagggcagaa caaggcagaa     2040

tcgcaggaaa cccgcttccc cttcctgaca gctcctgcca agccaaatgt gcttcctgca     2100

gctcacgccc accagctact gaagggaccc aaggcacccc ctgaagccag cgatagaggg     2160

tccctctctg ctccccagca gctcctgccc ccaaggcctg actgtatata ctgtaaatga     2220

aactttgttt gggtcaagct tccttctttc taacccccag actttggcct ctgagtgaaa     2280

tgtctctctt tgccctgtgg ggcttctctc cttgatgctt ctttcttttt ttaaagacaa     2340

cctgccatta ccacatgact caataaacca ttgctcttca tctcaggctt tggggttggc     2400

tggggaagga ggcatcccgg ggctgggctt tctcccaaga acatcagagc tgagtagccg     2460

acaaactcac tttggggccg tgggctggaa gggaccatct gatgccccag agctctggct     2520

tggccttctc cctctgcctt taattcacgt tgaacgctgg gtacctcact catcccaagt     2580

tcttcaacac tgagcaaatg caaggatagc acagtactga gccaaccata gactccccac     2640

aaggagttgc tgttgttatt aacaggaagc cagagaatca gcagggtggg ttagtgaggg     2700

atccgggaat agctgtgact ggagcctgca taaacagctc tgaagggaga gagaagactg     2760

ggctctcttg tgtgccaggc acagtatgga aggcttcata taagttaagc tgaaattagc     2820

cctgttttac atacagcttc attttacata tgaggaaact gaggctttga aaaaaatgag     2880

atgtcttgtc caagatgaaa agtagtagat tcaaccaagt cctcttactc taagcccaac     2940

gcttttaccc aaaaccccag agtcctcatc agggatgcca aatggttcta gacccagtgg     3000

aggttctgga gctgccactg gggatttaat ttcttttgat ttgctaaaga tttgacctga     3060

ctgaatggag aggtagagtg tagtgtggcc aggacaaggt gagggaggct gtagagactt     3120

agcactttag gccaaccacc tccaggaaat ctgggaaatg caatgtgaca gctcgggctc     3180

tgcactccag ggggctgtct ggtgtccaca tggaccttct ccatgtggga cacagctgga     3240

acaagggggc aggggcctgc agctgggatg cccaggtgaa tatgggcagc tggacaaaca     3300

acactgggat tgagtcagat agaaggggcc caaggactcc agggctggga ggacagaggc     3360

tgggagagag ggctcttacc tccttaggcc tcccaaagag cggttaggga tgctgccatg     3420

gatggcatgg cagggggaac cctcctggaa gaaaatccat ctcttctgaa gggatctgag     3480

atgcggctgg tttttcaatg gcagaacttc cctctgcagc gcgactccga atccatgaca     3540

tctgagagtc ttcctgacca caaacctctg ggatcccgag ggctccctac ccaagaatca     3600

ctttgagcac agcatcccaa ggagcccata gagcgatccc ttgcattcac agccacagcc     3660

cctctgggga cactctgtac ccccggcaga ccctttccaa ctcacaacca ataaaggggc     3720

ttgggctgtg ctttgactaa ggtgaaaaaa aaaaa                                3755


<210>  276
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Gly Glu Arg Trp Trp Gly Pro Arg Cys Pro Asp Thr His 
            260                 265                 270         


Pro Thr Ser Pro Pro Ala Asp Arg Ala Ala Met Pro Pro Leu Pro Ser 
        275                 280                 285             


Gln Ala Trp Trp Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr 
    290                 295                 300                 


Pro Pro Thr Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala 
305                 310                 315                 320 


Cys 
    


<210>  277
<211>  3653
<212>  DNA
<213>  Homo sapiens

<400>  277
gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc       60

aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg      120

ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc      180

catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc      240

tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg      300

cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta      360

ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac      420

ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg      480

ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt      540

cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga      600

cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt      660

aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct      720

cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag      780

ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac      840

ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta      900

cccagaggcc tatgcctccc ccagccacac caaaggcgag caggaagtga atactctggc      960

aatgcctatg gccacacccc ctactcctcc tacagcgagg cctggcgctt ccccaactcc     1020

agcttgctga gttccccata ttattacagt tccacatcaa ggccgagtgc accgcccacc     1080

actgccacgg cctttgacca tctgtagttg ccatggggac agtgggagcg actgagcaac     1140

aggaggactc agcctgggac aggccccaga gagtcacaca aaggaatctt tatttattac     1200

atgaaaaata accacaagtc cagcattgcg gcacactccc tgtgtggtta atttaatgaa     1260

ccatgaaaga caggatgacc ttggacaagg ccaaactgtc ctccaagact ccttaatgag     1320

gggcaggagt cccagggaaa gagaaccatg ccatgctgaa aaagacaaaa ttgaagaaga     1380

aatgtagccc ccagccggta cccaccaaag gagagaagaa gcaatagccg aggaacttgg     1440

ggggatggcg aatggttcct gcccgggccc aaggggtgca cagggcacct ccatggctcc     1500

attattaaca caactctagc aattatggac cataagcact tccctccagc ccacaagtca     1560

cagcctggtg ccgaggctct cctcaccagc cacccaggga gtcacctccc tcagcctccc     1620

gcctgcccca cacggaggct ctggctgtcc tctttctcca ctccatttgc ttggctcttt     1680

ctacacctcc ctcttgggca tgggctgagg gctggagcga gtccctcaga aattccacca     1740

ggctgtcagc tgacctcttt tgcctgctgc tgtgaaggta tagcaccacc ccaggtcctc     1800

ctgcagtgcg gcatcccctt ggcagctgcc gtcagccagg ccagccccag ggagcttaaa     1860

acagacattc cacagggcct gggcccctgg gaggtgaggt gtggtgtgcg gcttcaccca     1920

gggcagaaca aggcagaatc gcaggaaacc cgcttcccct tcctgacagc tcctgccaag     1980

ccaaatgtgc ttcctgcagc tcacgcccac cagctactga agggacccaa ggcaccccct     2040

gaagccagcg atagagggtc cctctctgct ccccagcagc tcctgccccc aaggcctgac     2100

tgtatatact gtaaatgaaa ctttgtttgg gtcaagcttc cttctttcta acccccagac     2160

tttggcctct gagtgaaatg tctctctttg ccctgtgggg cttctctcct tgatgcttct     2220

ttcttttttt aaagacaacc tgccattacc acatgactca ataaaccatt gctcttcatc     2280

tcaggctttg gggttggctg gggaaggagg catcccgggg ctgggctttc tcccaagaac     2340

atcagagctg agtagccgac aaactcactt tggggccgtg ggctggaagg gaccatctga     2400

tgccccagag ctctggcttg gccttctccc tctgccttta attcacgttg aacgctgggt     2460

acctcactca tcccaagttc ttcaacactg agcaaatgca aggatagcac agtactgagc     2520

caaccataga ctccccacaa ggagttgctg ttgttattaa caggaagcca gagaatcagc     2580

agggtgggtt agtgagggat ccgggaatag ctgtgactgg agcctgcata aacagctctg     2640

aagggagaga gaagactggg ctctcttgtg tgccaggcac agtatggaag gcttcatata     2700

agttaagctg aaattagccc tgttttacat acagcttcat tttacatatg aggaaactga     2760

ggctttgaaa aaaatgagat gtcttgtcca agatgaaaag tagtagattc aaccaagtcc     2820

tcttactcta agcccaacgc ttttacccaa aaccccagag tcctcatcag ggatgccaaa     2880

tggttctaga cccagtggag gttctggagc tgccactggg gatttaattt cttttgattt     2940

gctaaagatt tgacctgact gaatggagag gtagagtgta gtgtggccag gacaaggtga     3000

gggaggctgt agagacttag cactttaggc caaccacctc caggaaatct gggaaatgca     3060

atgtgacagc tcgggctctg cactccaggg ggctgtctgg tgtccacatg gaccttctcc     3120

atgtgggaca cagctggaac aagggggcag gggcctgcag ctgggatgcc caggtgaata     3180

tgggcagctg gacaaacaac actgggattg agtcagatag aaggggccca aggactccag     3240

ggctgggagg acagaggctg ggagagaggg ctcttacctc cttaggcctc ccaaagagcg     3300

gttagggatg ctgccatgga tggcatggca gggggaaccc tcctggaaga aaatccatct     3360

cttctgaagg gatctgagat gcggctggtt tttcaatggc agaacttccc tctgcagcgc     3420

gactccgaat ccatgacatc tgagagtctt cctgaccaca aacctctggg atcccgaggg     3480

ctccctaccc aagaatcact ttgagcacag catcccaagg agcccataga gcgatccctt     3540

gcattcacag ccacagcccc tctggggaca ctctgtaccc ccggcagacc ctttccaact     3600

cacaaccaat aaaggggctt gggctgtgct ttgactaagg tgaaaaaaaa aaa            3653


<210>  278
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr Pro Pro 
            260                 265                 270         


Thr Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala Cys 
        275                 280                 285         


<210>  279
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  279
gaattacaaa ggaggccgtc tgcctccttt gtcctggatt tgggagttga gcaccttcgt       60

cgccattggc tttcctcccc cagctccagc ctctctcatc ttgggaatct gcgtcagaag      120

tcactcgcag tcccgtcagc ccagaagacg taaagcaggc taccagcaat tttgagaact      180

tgcaaaaaca gcttgcaagg aaaatgaagc ttcctatttt catagcagat gcattcacag      240

caagagcatt tcgtgggaat cctgctgctg tttgcctcct agaaaatgaa ttggatgaag      300

acatgcatca gaaaattgca agggagatga acctctctga aactgctttt atccgaaaac      360

tgcacccgac agacaacttt gcacaaagtt cctgctttgg actgagatgg tttacaccag      420

cgagtgaggt cccactctgt ggccatgcca ccctggcttc tgcagctgtg ctgtttcaca      480

aaataaaaaa catgaatagc acgctcacgt ttgtcactct gagtggagaa ctaagggcca      540

gacgagcaga ggatggcatc gtcctggact tgcctcttta tccagcccac ccccaggact      600

tccatgaagt agaggacttg ataaagactg ccataggcaa cacactggtc caggacatct      660

gttattctcc agatacccaa aagctcctcg tccgcctcag tgacgtttac aacaggtcgt      720

ttctggagaa cctgaaagtg aacacggaga atctgctgca agttgaaaac acagggaagg      780

tgaaagggct tattcttacc cttaaaggag agcctggtgg gcagacccaa gcatttgact      840

tttactcaag atattttgca ccgtgggttg gtgtggctga agacccagtg acagggtctg      900

cacacgctgt tctcagcagc tactggtccc agcatctggg gaagaaagaa atgcatggta      960

ggacagctct ttaccaattt cttttttatt tgcctaattc gaagctagtg ttccttctca     1020

tatgtactat ccccttgaaa atgtaataca atgtcatgta tcacccatgt gaaaatgaaa     1080

ggttttaaaa ttccttcacc cttaaagatc ctccacccca aacagccttc acctctgcct     1140

cccccaacat acagagactg tacagacaca gatacagtaa ctgcccaata agtgtttgtt     1200

gaataaaata gctgtataac tttgaaaaa                                       1229


<210>  280
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Lys Leu Pro Ile Phe Ile Ala Asp Ala Phe Thr Ala Arg Ala Phe 
1               5                   10                  15      


Arg Gly Asn Pro Ala Ala Val Cys Leu Leu Glu Asn Glu Leu Asp Glu 
            20                  25                  30          


Asp Met His Gln Lys Ile Ala Arg Glu Met Asn Leu Ser Glu Thr Ala 
        35                  40                  45              


Phe Ile Arg Lys Leu His Pro Thr Asp Asn Phe Ala Gln Ser Ser Cys 
    50                  55                  60                  


Phe Gly Leu Arg Trp Phe Thr Pro Ala Ser Glu Val Pro Leu Cys Gly 
65                  70                  75                  80  


His Ala Thr Leu Ala Ser Ala Ala Val Leu Phe His Lys Ile Lys Asn 
                85                  90                  95      


Met Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly Glu Leu Arg Ala 
            100                 105                 110         


Arg Arg Ala Glu Asp Gly Ile Val Leu Asp Leu Pro Leu Tyr Pro Ala 
        115                 120                 125             


His Pro Gln Asp Phe His Glu Val Glu Asp Leu Ile Lys Thr Ala Ile 
    130                 135                 140                 


Gly Asn Thr Leu Val Gln Asp Ile Cys Tyr Ser Pro Asp Thr Gln Lys 
145                 150                 155                 160 


Leu Leu Val Arg Leu Ser Asp Val Tyr Asn Arg Ser Phe Leu Glu Asn 
                165                 170                 175     


Leu Lys Val Asn Thr Glu Asn Leu Leu Gln Val Glu Asn Thr Gly Lys 
            180                 185                 190         


Val Lys Gly Leu Ile Leu Thr Leu Lys Gly Glu Pro Gly Gly Gln Thr 
        195                 200                 205             


Gln Ala Phe Asp Phe Tyr Ser Arg Tyr Phe Ala Pro Trp Val Gly Val 
    210                 215                 220                 


Ala Glu Asp Pro Val Thr Gly Ser Ala His Ala Val Leu Ser Ser Tyr 
225                 230                 235                 240 


Trp Ser Gln His Leu Gly Lys Lys Glu Met His Gly Arg Thr Ala Leu 
                245                 250                 255     


Tyr Gln Phe Leu Phe Tyr Leu Pro Asn Ser Lys Leu Val Phe Leu Leu 
            260                 265                 270         


Ile Cys Thr Ile Pro Leu Lys Met 
        275                 280 


<210>  281
<211>  2587
<212>  DNA
<213>  Homo sapiens

<400>  281
gaattacaaa ggaggccgtc tgcctccttt gtcctggatt tgggagttga gcaccttcgt       60

cgccattggc tttcctcccc cagctccagc ctctctcatc ttgggaatct gcgtcagaag      120

tcactcgcag tcccgtcagc ccagaagacg taaagcaggc taccagcaat tttgagaact      180

tgcaaaaaca gcttgcaagg aaaatgaagc ttcctatttt catagcagat gcattcacag      240

caagagcatt tcgtgggaat cctgctgctg tttgcctcct agaaaatgaa ttggatgaag      300

acatgcatca gaaaattgca agggagatga acctctctga aactgctttt atccgaaaac      360

tgcacccgac agacaacttt gcacaaagtt cctgctttgg actgagatgg tttacaccag      420

cgagtgaggt cccactctgt ggccatgcca ccctggcttc tgcagctgtg ctgtttcaca      480

aaataaaaaa catgaatagc acgctcacgt ttgtcactct gagtggagaa ctaagggcca      540

gacgagcaga ggatggcatc gtcctggact tgcctcttta tccagcccac ccccaggact      600

tccatgaagt agaggacttg ataaagactg ccataggcaa cacactggtc caggacatct      660

gttattctcc agatacccaa aagctcctcg tccgcctcag tgacgtttac aacaggtcgt      720

ttctggagaa cctgaaagtg aacacggaga atctgctgca agttgaaaac acagggaagg      780

tgaaagggct tattcttacc cttaaaggag agcctggtgg gcagacccaa gcatttgact      840

tttactcaag atattttgca ccgtgggttg gtgtggctga agacccagtg acagggtctg      900

cacacgctgt tctcagcagc tactggtccc agcatctggg gaagaaagaa atgcatgctt      960

ttcagtgttc ccaccgagga ggagagctgg gaatttccct tcgtccagac ggaagggttg     1020

acattagagg aggtgcagct gttgttttag agggcacact gacagcctag aggtggttat     1080

gctgtgacgc tgctgtctct aaccaccaag tattttctgc ttaaaaagaa atgtaagggg     1140

ctgcctttag caaatgtgcg tagtagtcta cttaatcctc atgttaaaaa tcgaaaaatg     1200

ggccaggcgc agtggctcat gcctgtaatc gtagcacttt gagaggccaa ggtgggtgga     1260

tcacctgagg tcaggggttc gacaccagcc tggccaacat ggtgaaacct cgtctctact     1320

acaaatacaa aaattagctg ggtgtggtgc cacatgcctg taattccagc tacttgggag     1380

gctgaggcat ggagaatcgc ttgaacccag gaggcagaag ttgcagtgag cagagatcac     1440

accactgcac tccagcctgg gcaacagagt aagactccat ccacacacac acacacacac     1500

acaaaattga aaagtgaaga cattttaatg gagatttaat agtgcttcca gactaatgaa     1560

ctaatggagt tttggctcca ctcatgagtg tatttgaaat gtaagtaacc agctacaaag     1620

aataatgtca cttcatttga ttatgactac caatcaagag aaggaggaat acatttctga     1680

ggagtgatac taaaccattt gagcttaaat gagtacctga ttttgcagcc attaaaatga     1740

gtcaataact atgtggaaat atagaaaaat attttataat ataatactaa gaaagaggac     1800

agtaggccat aaagtgttag cagtgttatg ctatgtctat ataaataagc atgggccatt     1860

aaaaatagca aactgaaaac agttcatgtg tggggggcaa gtttagaagt aattttaatg     1920

tatctaagaa gtgatttcct ttattgttgt actcaggtac gaagactaaa aatcaggatg     1980

aatccagaaa attaacacaa aaaagtatgt attaggctac ttcctgtcat agtgaaatta     2040

aacactcaaa gtaatgtaat ctcagctggg cgtggcggct catgcctgta atcccagcac     2100

tttggcagga caaggcagga ggatcacttg aacctaggag ttcgagacca gcctgggcaa     2160

cacagcgaga acttgtctct attaaaaaaa aaaaaaggaa tgtaatttca atctttttct     2220

tgatatatgg cttgagaatg ataatgtaaa aggaattctt ctcttacttc aataaaatgg     2280

gttttaacat aactttaaat tcagttaaat atacaatatt gaatacctat agttgacttt     2340

gggatgggga ctttttcaag tcattaagag tgtttgttta aggtgatctc attgatggta     2400

gttctcagcc gtctcaaaaa ctgcaagcta atcagtcaga cattctttaa tgaccccaat     2460

tttttcactt taattgttac catgttttct atttttactg atttttgcta aagcatgtaa     2520

gagtgaattt attatagcag taatcttgtg tttctcctga tgtgcaataa atcaataatt     2580

caccagc                                                               2587


<210>  282
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Lys Leu Pro Ile Phe Ile Ala Asp Ala Phe Thr Ala Arg Ala Phe 
1               5                   10                  15      


Arg Gly Asn Pro Ala Ala Val Cys Leu Leu Glu Asn Glu Leu Asp Glu 
            20                  25                  30          


Asp Met His Gln Lys Ile Ala Arg Glu Met Asn Leu Ser Glu Thr Ala 
        35                  40                  45              


Phe Ile Arg Lys Leu His Pro Thr Asp Asn Phe Ala Gln Ser Ser Cys 
    50                  55                  60                  


Phe Gly Leu Arg Trp Phe Thr Pro Ala Ser Glu Val Pro Leu Cys Gly 
65                  70                  75                  80  


His Ala Thr Leu Ala Ser Ala Ala Val Leu Phe His Lys Ile Lys Asn 
                85                  90                  95      


Met Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly Glu Leu Arg Ala 
            100                 105                 110         


Arg Arg Ala Glu Asp Gly Ile Val Leu Asp Leu Pro Leu Tyr Pro Ala 
        115                 120                 125             


His Pro Gln Asp Phe His Glu Val Glu Asp Leu Ile Lys Thr Ala Ile 
    130                 135                 140                 


Gly Asn Thr Leu Val Gln Asp Ile Cys Tyr Ser Pro Asp Thr Gln Lys 
145                 150                 155                 160 


Leu Leu Val Arg Leu Ser Asp Val Tyr Asn Arg Ser Phe Leu Glu Asn 
                165                 170                 175     


Leu Lys Val Asn Thr Glu Asn Leu Leu Gln Val Glu Asn Thr Gly Lys 
            180                 185                 190         


Val Lys Gly Leu Ile Leu Thr Leu Lys Gly Glu Pro Gly Gly Gln Thr 
        195                 200                 205             


Gln Ala Phe Asp Phe Tyr Ser Arg Tyr Phe Ala Pro Trp Val Gly Val 
    210                 215                 220                 


Ala Glu Asp Pro Val Thr Gly Ser Ala His Ala Val Leu Ser Ser Tyr 
225                 230                 235                 240 


Trp Ser Gln His Leu Gly Lys Lys Glu Met His Ala Phe Gln Cys Ser 
                245                 250                 255     


His Arg Gly Gly Glu Leu Gly Ile Ser Leu Arg Pro Asp Gly Arg Val 
            260                 265                 270         


Asp Ile Arg Gly Gly Ala Ala Val Val Leu Glu Gly Thr Leu Thr Ala 
        275                 280                 285             


<210>  283
<211>  3082
<212>  DNA
<213>  Homo sapiens

<400>  283
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagtccccc ccgaagggcg tgaccatccc gtaccggccc aagccgtcca      900

gctctccggt catctttgca ggtggtcagg cctataccat tcaaggacag tatgccattc      960

cacagccaga tttgaccaag ctgcaccagt tggcaatgca acagtctcat tttcccatga     1020

cgcatggcaa caccggattc agtggcattg aatccagctc tccagaggtg aaaggctatt     1080

gggcaggttt ggatgcatct gctcagacta cttctcatga actcaccatt ccaaacgatt     1140

tgattggctg cataatcggg cgtcaaggcg ccaaaatcaa tgagatccgt cagatgtctg     1200

gggcgcagat caaaattgcg aacccagtgg aaggatctac tgataggcag gttaccatca     1260

ctggatctgc tgccagcatt agcctggctc aatatctaat caatgtcagg ctttcctcgg     1320

agacgggtgg catggggagc agctagaaca atgcagattc atccataatc cctttctgct     1380

gttcaccacc acccatgatc catctgtgta gtttctgaac agtcagcgat tccaggtttt     1440

aaatagtttg taaattttca gtttctacac actttatcat ccactcgtga ttttttaatt     1500

aaagcgtttt aattcctttc tctgttcagc tgttgatgct gagatccata tttagtttta     1560

taagcttctc cctggttttt tttttttggc tcatgaattt ttctgtttgt catggaaatg     1620

taagagtgga atattaatac atttcagttt agttctgtaa tgtcaggaat ttttcaaaaa     1680

aattaaaaga tggactggag ctttttcttt gtgaatagaa actggatgcc acagtgattc     1740

atgtgggttt tattcctctt gtcttgctgt tatttttgta ccttttatcc ctcaaaggac     1800

ccttcttggg ttttgaatgg aagcctttat tccggttaag atgttttctt ctattttacc     1860

acttccatct ttttttgtgg ccctcgatcc tatttttccc tgactccatg cttggttggc     1920

ccttataaaa cttgtgccca aaagattgag gattagactt tccgaggact tacctgtcct     1980

aggggagtag gcaagcactt ccactaggga gggggtgggg gaaaggaatg acacatgaca     2040

tacatggcat acacattaag cagttgatca tatgtctgac tgggttccag tttcttggga     2100

atgttggtcc ccttgttcag gcttgcatat tttaaactaa aaatttcagt ctattgtttt     2160

tagtaacttc atttatagtc ctccataaca agttagaagg atgtatctgc taccatttat     2220

tcctataatt ttagaaagtt ggggcttgac attatactca tttagtgaga gtagatgcaa     2280

aaaagtggag gggcaggaga acttctccag acacctcaga taaagtccgg agcccaaggc     2340

tttatcttaa ccatgtatgg taccccattc attcatcaag aaaaccctca acagctgggc     2400

ctgcatggag tgttatattt caaggttttt cacaggggtt acagtaggac agtccccacc     2460

ccaatcaggc accaggataa aagcagggac ttaaacagca ccccggttct tcagcctgag     2520

ccatcacatg ctatcagtct cctaacctcc ccctgggcct taagacaggg cttgggcaga     2580

gaagataaat ggtgggacaa aaaaatgagt tacattgcca cctgagaaac ctcagagggg     2640

aggacccagc cttagcctcc ctcctcccaa gtgcaaaatg tgtaaacaga gtaaacggaa     2700

cagaaaagtg cagtctaagt ggttttctct cctgcccctc ccaccgcccc tccccccacc     2760

ccctattatt tggggataaa gaatataaag acaaccctgg cttttctatt gccttgttgc     2820

ttgctgaata taaggaatgg ggtggggcag gaaggggctt gcccttagcc acagctctac     2880

ggctgtgcct cattcatttc cacagctgcc agtgtcccta gagtttatca ggtgaattgg     2940

tcaggggatc agtctccctc gagcctgact tacggctggg acagccccat ctttctgttg     3000

attatgtggc gcatatatat atatatatgt atatatatat aatttatata aatatttctc     3060

tatgtaaaaa aaaaaaaaaa aa                                              3082


<210>  284
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Val Thr Ile 
                165                 170                 175     


Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile Phe Ala Gly Gly 
            180                 185                 190         


Gln Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln Pro Asp Leu 
        195                 200                 205             


Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe Pro Met Thr 
    210                 215                 220                 


His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser Pro Glu Val 
225                 230                 235                 240 


Lys Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln Thr Thr Ser His 
                245                 250                 255     


Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile Gly Arg Gln 
            260                 265                 270         


Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala Gln Ile Lys 
        275                 280                 285             


Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val Thr Ile Thr 
    290                 295                 300                 


Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile Asn Val Arg 
305                 310                 315                 320 


Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
                325                 330     


<210>  285
<211>  3184
<212>  DNA
<213>  Homo sapiens

<400>  285
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagactctc tcccagtccc ccccgaaggg cgtgaccatc ccgtaccggc      900

ccaagccgtc cagctctccg gtcatctttg caggtggtca ggacaggtac agcacaggca      960

gcgacagtgc gagctttccc cacaccaccc cgtccatgtg cctcaaccct gacctggagg     1020

gaccacctct agaggcctat accattcaag gacagtatgc cattccacag ccagatttga     1080

ccaagctgca ccagttggca atgcaacagt ctcattttcc catgacgcat ggcaacaccg     1140

gattcagtgg cattgaatcc agctctccag aggtgaaagg ctattggggt ttggatgcat     1200

ctgctcagac tacttctcat gaactcacca ttccaaacga tttgattggc tgcataatcg     1260

ggcgtcaagg cgccaaaatc aatgagatcc gtcagatgtc tggggcgcag atcaaaattg     1320

cgaacccagt ggaaggatct actgataggc aggttaccat cactggatct gctgccagca     1380

ttagcctggc tcaatatcta atcaatgtca ggctttcctc ggagacgggt ggcatgggga     1440

gcagctagaa caatgcagat tcatccataa tccctttctg ctgttcacca ccacccatga     1500

tccatctgtg tagtttctga acagtcagcg attccaggtt ttaaatagtt tgtaaatttt     1560

cagtttctac acactttatc atccactcgt gattttttaa ttaaagcgtt ttaattcctt     1620

tctctgttca gctgttgatg ctgagatcca tatttagttt tataagcttc tccctggttt     1680

tttttttttg gctcatgaat ttttctgttt gtcatggaaa tgtaagagtg gaatattaat     1740

acatttcagt ttagttctgt aatgtcagga atttttcaaa aaaattaaaa gatggactgg     1800

agctttttct ttgtgaatag aaactggatg ccacagtgat tcatgtgggt tttattcctc     1860

ttgtcttgct gttatttttg taccttttat ccctcaaagg acccttcttg ggttttgaat     1920

ggaagccttt attccggtta agatgttttc ttctatttta ccacttccat ctttttttgt     1980

ggccctcgat cctatttttc cctgactcca tgcttggttg gcccttataa aacttgtgcc     2040

caaaagattg aggattagac tttccgagga cttacctgtc ctaggggagt aggcaagcac     2100

ttccactagg gagggggtgg gggaaaggaa tgacacatga catacatggc atacacatta     2160

agcagttgat catatgtctg actgggttcc agtttcttgg gaatgttggt ccccttgttc     2220

aggcttgcat attttaaact aaaaatttca gtctattgtt tttagtaact tcatttatag     2280

tcctccataa caagttagaa ggatgtatct gctaccattt attcctataa ttttagaaag     2340

ttggggcttg acattatact catttagtga gagtagatgc aaaaaagtgg aggggcagga     2400

gaacttctcc agacacctca gataaagtcc ggagcccaag gctttatctt aaccatgtat     2460

ggtaccccat tcattcatca agaaaaccct caacagctgg gcctgcatgg agtgttatat     2520

ttcaaggttt ttcacagggg ttacagtagg acagtcccca ccccaatcag gcaccaggat     2580

aaaagcaggg acttaaacag caccccggtt cttcagcctg agccatcaca tgctatcagt     2640

ctcctaacct ccccctgggc cttaagacag ggcttgggca gagaagataa atggtgggac     2700

aaaaaaatga gttacattgc cacctgagaa acctcagagg ggaggaccca gccttagcct     2760

ccctcctccc aagtgcaaaa tgtgtaaaca gagtaaacgg aacagaaaag tgcagtctaa     2820

gtggttttct ctcctgcccc tcccaccgcc cctcccccca ccccctatta tttggggata     2880

aagaatataa agacaaccct ggcttttcta ttgccttgtt gcttgctgaa tataaggaat     2940

ggggtggggc aggaaggggc ttgcccttag ccacagctct acggctgtgc ctcattcatt     3000

tccacagctg ccagtgtccc tagagtttat caggtgaatt ggtcagggga tcagtctccc     3060

tcgagcctga cttacggctg ggacagcccc atctttctgt tgattatgtg gcgcatatat     3120

atatatatat gtatatatat ataatttata taaatatttc tctatgtaaa aaaaaaaaaa     3180

aaaa                                                                  3184


<210>  286
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser 
        195                 200                 205             


Phe Pro His Thr Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly 
    210                 215                 220                 


Pro Pro Leu Glu Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln 
225                 230                 235                 240 


Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe 
                245                 250                 255     


Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser 
            260                 265                 270         


Pro Glu Val Lys Gly Tyr Trp Gly Leu Asp Ala Ser Ala Gln Thr Thr 
        275                 280                 285             


Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile Gly 
    290                 295                 300                 


Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala Gln 
305                 310                 315                 320 


Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val Thr 
                325                 330                 335     


Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile Asn 
            340                 345                 350         


Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360                 365 


<210>  287
<211>  3172
<212>  DNA
<213>  Homo sapiens

<400>  287
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagtccccc ccgaagggcg tgaccatccc gtaccggccc aagccgtcca      900

gctctccggt catctttgca ggtggtcagg acaggtacag cacaggcagc gacagtgcga      960

gctttcccca caccaccccg tccatgtgcc tcaaccctga cctggaggga ccacctctag     1020

aggcctatac cattcaagga cagtatgcca ttccacagcc agatttgacc aagctgcacc     1080

agttggcaat gcaacagtct cattttccca tgacgcatgg caacaccgga ttcagtggca     1140

ttgaatccag ctctccagag gtgaaaggct attggggttt ggatgcatct gctcagacta     1200

cttctcatga actcaccatt ccaaacgatt tgattggctg cataatcggg cgtcaaggcg     1260

ccaaaatcaa tgagatccgt cagatgtctg gggcgcagat caaaattgcg aacccagtgg     1320

aaggatctac tgataggcag gttaccatca ctggatctgc tgccagcatt agcctggctc     1380

aatatctaat caatgtcagg ctttcctcgg agacgggtgg catggggagc agctagaaca     1440

atgcagattc atccataatc cctttctgct gttcaccacc acccatgatc catctgtgta     1500

gtttctgaac agtcagcgat tccaggtttt aaatagtttg taaattttca gtttctacac     1560

actttatcat ccactcgtga ttttttaatt aaagcgtttt aattcctttc tctgttcagc     1620

tgttgatgct gagatccata tttagtttta taagcttctc cctggttttt tttttttggc     1680

tcatgaattt ttctgtttgt catggaaatg taagagtgga atattaatac atttcagttt     1740

agttctgtaa tgtcaggaat ttttcaaaaa aattaaaaga tggactggag ctttttcttt     1800

gtgaatagaa actggatgcc acagtgattc atgtgggttt tattcctctt gtcttgctgt     1860

tatttttgta ccttttatcc ctcaaaggac ccttcttggg ttttgaatgg aagcctttat     1920

tccggttaag atgttttctt ctattttacc acttccatct ttttttgtgg ccctcgatcc     1980

tatttttccc tgactccatg cttggttggc ccttataaaa cttgtgccca aaagattgag     2040

gattagactt tccgaggact tacctgtcct aggggagtag gcaagcactt ccactaggga     2100

gggggtgggg gaaaggaatg acacatgaca tacatggcat acacattaag cagttgatca     2160

tatgtctgac tgggttccag tttcttggga atgttggtcc ccttgttcag gcttgcatat     2220

tttaaactaa aaatttcagt ctattgtttt tagtaacttc atttatagtc ctccataaca     2280

agttagaagg atgtatctgc taccatttat tcctataatt ttagaaagtt ggggcttgac     2340

attatactca tttagtgaga gtagatgcaa aaaagtggag gggcaggaga acttctccag     2400

acacctcaga taaagtccgg agcccaaggc tttatcttaa ccatgtatgg taccccattc     2460

attcatcaag aaaaccctca acagctgggc ctgcatggag tgttatattt caaggttttt     2520

cacaggggtt acagtaggac agtccccacc ccaatcaggc accaggataa aagcagggac     2580

ttaaacagca ccccggttct tcagcctgag ccatcacatg ctatcagtct cctaacctcc     2640

ccctgggcct taagacaggg cttgggcaga gaagataaat ggtgggacaa aaaaatgagt     2700

tacattgcca cctgagaaac ctcagagggg aggacccagc cttagcctcc ctcctcccaa     2760

gtgcaaaatg tgtaaacaga gtaaacggaa cagaaaagtg cagtctaagt ggttttctct     2820

cctgcccctc ccaccgcccc tccccccacc ccctattatt tggggataaa gaatataaag     2880

acaaccctgg cttttctatt gccttgttgc ttgctgaata taaggaatgg ggtggggcag     2940

gaaggggctt gcccttagcc acagctctac ggctgtgcct cattcatttc cacagctgcc     3000

agtgtcccta gagtttatca ggtgaattgg tcaggggatc agtctccctc gagcctgact     3060

tacggctggg acagccccat ctttctgttg attatgtggc gcatatatat atatatatgt     3120

atatatatat aatttatata aatatttctc tatgtaaaaa aaaaaaaaaa aa             3172


<210>  288
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Val Thr Ile 
                165                 170                 175     


Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile Phe Ala Gly Gly 
            180                 185                 190         


Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser Phe Pro His Thr 
        195                 200                 205             


Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly Pro Pro Leu Glu 
    210                 215                 220                 


Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln Pro Asp Leu Thr 
225                 230                 235                 240 


Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe Pro Met Thr His 
                245                 250                 255     


Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser Pro Glu Val Lys 
            260                 265                 270         


Gly Tyr Trp Gly Leu Asp Ala Ser Ala Gln Thr Thr Ser His Glu Leu 
        275                 280                 285             


Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala 
    290                 295                 300                 


Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala 
305                 310                 315                 320 


Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val Thr Ile Thr Gly Ser 
                325                 330                 335     


Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile Asn Val Arg Leu Ser 
            340                 345                 350         


Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360     


<210>  289
<211>  3094
<212>  DNA
<213>  Homo sapiens

<400>  289
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagactctc tcccagtccc ccccgaaggg cgtgaccatc ccgtaccggc      900

ccaagccgtc cagctctccg gtcatctttg caggtggtca ggcctatacc attcaaggac      960

agtatgccat tccacagcca gatttgacca agctgcacca gttggcaatg caacagtctc     1020

attttcccat gacgcatggc aacaccggat tcagtggcat tgaatccagc tctccagagg     1080

tgaaaggcta ttgggcaggt ttggatgcat ctgctcagac tacttctcat gaactcacca     1140

ttccaaacga tttgattggc tgcataatcg ggcgtcaagg cgccaaaatc aatgagatcc     1200

gtcagatgtc tggggcgcag atcaaaattg cgaacccagt ggaaggatct actgataggc     1260

aggttaccat cactggatct gctgccagca ttagcctggc tcaatatcta atcaatgtca     1320

ggctttcctc ggagacgggt ggcatgggga gcagctagaa caatgcagat tcatccataa     1380

tccctttctg ctgttcacca ccacccatga tccatctgtg tagtttctga acagtcagcg     1440

attccaggtt ttaaatagtt tgtaaatttt cagtttctac acactttatc atccactcgt     1500

gattttttaa ttaaagcgtt ttaattcctt tctctgttca gctgttgatg ctgagatcca     1560

tatttagttt tataagcttc tccctggttt tttttttttg gctcatgaat ttttctgttt     1620

gtcatggaaa tgtaagagtg gaatattaat acatttcagt ttagttctgt aatgtcagga     1680

atttttcaaa aaaattaaaa gatggactgg agctttttct ttgtgaatag aaactggatg     1740

ccacagtgat tcatgtgggt tttattcctc ttgtcttgct gttatttttg taccttttat     1800

ccctcaaagg acccttcttg ggttttgaat ggaagccttt attccggtta agatgttttc     1860

ttctatttta ccacttccat ctttttttgt ggccctcgat cctatttttc cctgactcca     1920

tgcttggttg gcccttataa aacttgtgcc caaaagattg aggattagac tttccgagga     1980

cttacctgtc ctaggggagt aggcaagcac ttccactagg gagggggtgg gggaaaggaa     2040

tgacacatga catacatggc atacacatta agcagttgat catatgtctg actgggttcc     2100

agtttcttgg gaatgttggt ccccttgttc aggcttgcat attttaaact aaaaatttca     2160

gtctattgtt tttagtaact tcatttatag tcctccataa caagttagaa ggatgtatct     2220

gctaccattt attcctataa ttttagaaag ttggggcttg acattatact catttagtga     2280

gagtagatgc aaaaaagtgg aggggcagga gaacttctcc agacacctca gataaagtcc     2340

ggagcccaag gctttatctt aaccatgtat ggtaccccat tcattcatca agaaaaccct     2400

caacagctgg gcctgcatgg agtgttatat ttcaaggttt ttcacagggg ttacagtagg     2460

acagtcccca ccccaatcag gcaccaggat aaaagcaggg acttaaacag caccccggtt     2520

cttcagcctg agccatcaca tgctatcagt ctcctaacct ccccctgggc cttaagacag     2580

ggcttgggca gagaagataa atggtgggac aaaaaaatga gttacattgc cacctgagaa     2640

acctcagagg ggaggaccca gccttagcct ccctcctccc aagtgcaaaa tgtgtaaaca     2700

gagtaaacgg aacagaaaag tgcagtctaa gtggttttct ctcctgcccc tcccaccgcc     2760

cctcccccca ccccctatta tttggggata aagaatataa agacaaccct ggcttttcta     2820

ttgccttgtt gcttgctgaa tataaggaat ggggtggggc aggaaggggc ttgcccttag     2880

ccacagctct acggctgtgc ctcattcatt tccacagctg ccagtgtccc tagagtttat     2940

caggtgaatt ggtcagggga tcagtctccc tcgagcctga cttacggctg ggacagcccc     3000

atctttctgt tgattatgtg gcgcatatat atatatatat gtatatatat ataatttata     3060

taaatatttc tctatgtaaa aaaaaaaaaa aaaa                                 3094


<210>  290
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro 
        195                 200                 205             


Gln Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His 
    210                 215                 220                 


Phe Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser 
225                 230                 235                 240 


Ser Pro Glu Val Lys Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln 
                245                 250                 255     


Thr Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile 
            260                 265                 270         


Ile Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly 
        275                 280                 285             


Ala Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln 
    290                 295                 300                 


Val Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu 
305                 310                 315                 320 


Ile Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
                325                 330                 335 


<210>  291
<211>  3043
<212>  DNA
<213>  Homo sapiens

<400>  291
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagtccccc ccgaagggcg tgaccatccc gtaccggccc aagccgtcca      900

gctctccggt catctttgca ggtggtcagg cctataccat tcaaggacag tatgccattc      960

cacagccaga tttgaccaag ctgcaccagt tggcaatgca acagtctcat tttcccatga     1020

cgcatggcaa caccggattc agtgcaggtt tggatgcatc tgctcagact acttctcatg     1080

aactcaccat tccaaacgat ttgattggct gcataatcgg gcgtcaaggc gccaaaatca     1140

atgagatccg tcagatgtct ggggcgcaga tcaaaattgc gaacccagtg gaaggatcta     1200

ctgataggca ggttaccatc actggatctg ctgccagcat tagcctggct caatatctaa     1260

tcaatgtcag gctttcctcg gagacgggtg gcatggggag cagctagaac aatgcagatt     1320

catccataat ccctttctgc tgttcaccac cacccatgat ccatctgtgt agtttctgaa     1380

cagtcagcga ttccaggttt taaatagttt gtaaattttc agtttctaca cactttatca     1440

tccactcgtg attttttaat taaagcgttt taattccttt ctctgttcag ctgttgatgc     1500

tgagatccat atttagtttt ataagcttct ccctggtttt ttttttttgg ctcatgaatt     1560

tttctgtttg tcatggaaat gtaagagtgg aatattaata catttcagtt tagttctgta     1620

atgtcaggaa tttttcaaaa aaattaaaag atggactgga gctttttctt tgtgaataga     1680

aactggatgc cacagtgatt catgtgggtt ttattcctct tgtcttgctg ttatttttgt     1740

accttttatc cctcaaagga cccttcttgg gttttgaatg gaagccttta ttccggttaa     1800

gatgttttct tctattttac cacttccatc tttttttgtg gccctcgatc ctatttttcc     1860

ctgactccat gcttggttgg cccttataaa acttgtgccc aaaagattga ggattagact     1920

ttccgaggac ttacctgtcc taggggagta ggcaagcact tccactaggg agggggtggg     1980

ggaaaggaat gacacatgac atacatggca tacacattaa gcagttgatc atatgtctga     2040

ctgggttcca gtttcttggg aatgttggtc cccttgttca ggcttgcata ttttaaacta     2100

aaaatttcag tctattgttt ttagtaactt catttatagt cctccataac aagttagaag     2160

gatgtatctg ctaccattta ttcctataat tttagaaagt tggggcttga cattatactc     2220

atttagtgag agtagatgca aaaaagtgga ggggcaggag aacttctcca gacacctcag     2280

ataaagtccg gagcccaagg ctttatctta accatgtatg gtaccccatt cattcatcaa     2340

gaaaaccctc aacagctggg cctgcatgga gtgttatatt tcaaggtttt tcacaggggt     2400

tacagtagga cagtccccac cccaatcagg caccaggata aaagcaggga cttaaacagc     2460

accccggttc ttcagcctga gccatcacat gctatcagtc tcctaacctc cccctgggcc     2520

ttaagacagg gcttgggcag agaagataaa tggtgggaca aaaaaatgag ttacattgcc     2580

acctgagaaa cctcagaggg gaggacccag ccttagcctc cctcctccca agtgcaaaat     2640

gtgtaaacag agtaaacgga acagaaaagt gcagtctaag tggttttctc tcctgcccct     2700

cccaccgccc ctccccccac cccctattat ttggggataa agaatataaa gacaaccctg     2760

gcttttctat tgccttgttg cttgctgaat ataaggaatg gggtggggca ggaaggggct     2820

tgcccttagc cacagctcta cggctgtgcc tcattcattt ccacagctgc cagtgtccct     2880

agagtttatc aggtgaattg gtcaggggat cagtctccct cgagcctgac ttacggctgg     2940

gacagcccca tctttctgtt gattatgtgg cgcatatata tatatatatg tatatatata     3000

taatttatat aaatatttct ctatgtaaaa aaaaaaaaaa aaa                       3043


<210>  292
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Val Thr Ile 
                165                 170                 175     


Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile Phe Ala Gly Gly 
            180                 185                 190         


Gln Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln Pro Asp Leu 
        195                 200                 205             


Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe Pro Met Thr 
    210                 215                 220                 


His Gly Asn Thr Gly Phe Ser Ala Gly Leu Asp Ala Ser Ala Gln Thr 
225                 230                 235                 240 


Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile 
                245                 250                 255     


Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala 
            260                 265                 270         


Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val 
        275                 280                 285             


Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile 
    290                 295                 300                 


Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
305                 310                 315             


<210>  293
<211>  3187
<212>  DNA
<213>  Homo sapiens

<400>  293
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagactctc tcccagtccc ccccgaaggg cgtgaccatc ccgtaccggc      900

ccaagccgtc cagctctccg gtcatctttg caggtggtca ggacaggtac agcacaggca      960

gcgacagtgc gagctttccc cacaccaccc cgtccatgtg cctcaaccct gacctggagg     1020

gaccacctct agaggcctat accattcaag gacagtatgc cattccacag ccagatttga     1080

ccaagctgca ccagttggca atgcaacagt ctcattttcc catgacgcat ggcaacaccg     1140

gattcagtgg cattgaatcc agctctccag aggtgaaagg ctattgggca ggtttggatg     1200

catctgctca gactacttct catgaactca ccattccaaa cgatttgatt ggctgcataa     1260

tcgggcgtca aggcgccaaa atcaatgaga tccgtcagat gtctggggcg cagatcaaaa     1320

ttgcgaaccc agtggaagga tctactgata ggcaggttac catcactgga tctgctgcca     1380

gcattagcct ggctcaatat ctaatcaatg tcaggctttc ctcggagacg ggtggcatgg     1440

ggagcagcta gaacaatgca gattcatcca taatcccttt ctgctgttca ccaccaccca     1500

tgatccatct gtgtagtttc tgaacagtca gcgattccag gttttaaata gtttgtaaat     1560

tttcagtttc tacacacttt atcatccact cgtgattttt taattaaagc gttttaattc     1620

ctttctctgt tcagctgttg atgctgagat ccatatttag ttttataagc ttctccctgg     1680

tttttttttt ttggctcatg aatttttctg tttgtcatgg aaatgtaaga gtggaatatt     1740

aatacatttc agtttagttc tgtaatgtca ggaatttttc aaaaaaatta aaagatggac     1800

tggagctttt tctttgtgaa tagaaactgg atgccacagt gattcatgtg ggttttattc     1860

ctcttgtctt gctgttattt ttgtaccttt tatccctcaa aggacccttc ttgggttttg     1920

aatggaagcc tttattccgg ttaagatgtt ttcttctatt ttaccacttc catctttttt     1980

tgtggccctc gatcctattt ttccctgact ccatgcttgg ttggccctta taaaacttgt     2040

gcccaaaaga ttgaggatta gactttccga ggacttacct gtcctagggg agtaggcaag     2100

cacttccact agggaggggg tgggggaaag gaatgacaca tgacatacat ggcatacaca     2160

ttaagcagtt gatcatatgt ctgactgggt tccagtttct tgggaatgtt ggtccccttg     2220

ttcaggcttg catattttaa actaaaaatt tcagtctatt gtttttagta acttcattta     2280

tagtcctcca taacaagtta gaaggatgta tctgctacca tttattccta taattttaga     2340

aagttggggc ttgacattat actcatttag tgagagtaga tgcaaaaaag tggaggggca     2400

ggagaacttc tccagacacc tcagataaag tccggagccc aaggctttat cttaaccatg     2460

tatggtaccc cattcattca tcaagaaaac cctcaacagc tgggcctgca tggagtgtta     2520

tatttcaagg tttttcacag gggttacagt aggacagtcc ccaccccaat caggcaccag     2580

gataaaagca gggacttaaa cagcaccccg gttcttcagc ctgagccatc acatgctatc     2640

agtctcctaa cctccccctg ggccttaaga cagggcttgg gcagagaaga taaatggtgg     2700

gacaaaaaaa tgagttacat tgccacctga gaaacctcag aggggaggac ccagccttag     2760

cctccctcct cccaagtgca aaatgtgtaa acagagtaaa cggaacagaa aagtgcagtc     2820

taagtggttt tctctcctgc ccctcccacc gcccctcccc ccacccccta ttatttgggg     2880

ataaagaata taaagacaac cctggctttt ctattgcctt gttgcttgct gaatataagg     2940

aatggggtgg ggcaggaagg ggcttgccct tagccacagc tctacggctg tgcctcattc     3000

atttccacag ctgccagtgt ccctagagtt tatcaggtga attggtcagg ggatcagtct     3060

ccctcgagcc tgacttacgg ctgggacagc cccatctttc tgttgattat gtggcgcata     3120

tatatatata tatgtatata tatataattt atataaatat ttctctatgt aaaaaaaaaa     3180

aaaaaaa                                                               3187


<210>  294
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser 
        195                 200                 205             


Phe Pro His Thr Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly 
    210                 215                 220                 


Pro Pro Leu Glu Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln 
225                 230                 235                 240 


Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe 
                245                 250                 255     


Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser 
            260                 265                 270         


Pro Glu Val Lys Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln Thr 
        275                 280                 285             


Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile 
    290                 295                 300                 


Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala 
305                 310                 315                 320 


Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val 
                325                 330                 335     


Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile 
            340                 345                 350         


Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360                 365     


<210>  295
<211>  3175
<212>  DNA
<213>  Homo sapiens

<400>  295
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagtccccc ccgaagggcg tgaccatccc gtaccggccc aagccgtcca      900

gctctccggt catctttgca ggtggtcagg acaggtacag cacaggcagc gacagtgcga      960

gctttcccca caccaccccg tccatgtgcc tcaaccctga cctggaggga ccacctctag     1020

aggcctatac cattcaagga cagtatgcca ttccacagcc agatttgacc aagctgcacc     1080

agttggcaat gcaacagtct cattttccca tgacgcatgg caacaccgga ttcagtggca     1140

ttgaatccag ctctccagag gtgaaaggct attgggcagg tttggatgca tctgctcaga     1200

ctacttctca tgaactcacc attccaaacg atttgattgg ctgcataatc gggcgtcaag     1260

gcgccaaaat caatgagatc cgtcagatgt ctggggcgca gatcaaaatt gcgaacccag     1320

tggaaggatc tactgatagg caggttacca tcactggatc tgctgccagc attagcctgg     1380

ctcaatatct aatcaatgtc aggctttcct cggagacggg tggcatgggg agcagctaga     1440

acaatgcaga ttcatccata atccctttct gctgttcacc accacccatg atccatctgt     1500

gtagtttctg aacagtcagc gattccaggt tttaaatagt ttgtaaattt tcagtttcta     1560

cacactttat catccactcg tgatttttta attaaagcgt tttaattcct ttctctgttc     1620

agctgttgat gctgagatcc atatttagtt ttataagctt ctccctggtt tttttttttt     1680

ggctcatgaa tttttctgtt tgtcatggaa atgtaagagt ggaatattaa tacatttcag     1740

tttagttctg taatgtcagg aatttttcaa aaaaattaaa agatggactg gagctttttc     1800

tttgtgaata gaaactggat gccacagtga ttcatgtggg ttttattcct cttgtcttgc     1860

tgttattttt gtacctttta tccctcaaag gacccttctt gggttttgaa tggaagcctt     1920

tattccggtt aagatgtttt cttctatttt accacttcca tctttttttg tggccctcga     1980

tcctattttt ccctgactcc atgcttggtt ggcccttata aaacttgtgc ccaaaagatt     2040

gaggattaga ctttccgagg acttacctgt cctaggggag taggcaagca cttccactag     2100

ggagggggtg ggggaaagga atgacacatg acatacatgg catacacatt aagcagttga     2160

tcatatgtct gactgggttc cagtttcttg ggaatgttgg tccccttgtt caggcttgca     2220

tattttaaac taaaaatttc agtctattgt ttttagtaac ttcatttata gtcctccata     2280

acaagttaga aggatgtatc tgctaccatt tattcctata attttagaaa gttggggctt     2340

gacattatac tcatttagtg agagtagatg caaaaaagtg gaggggcagg agaacttctc     2400

cagacacctc agataaagtc cggagcccaa ggctttatct taaccatgta tggtacccca     2460

ttcattcatc aagaaaaccc tcaacagctg ggcctgcatg gagtgttata tttcaaggtt     2520

tttcacaggg gttacagtag gacagtcccc accccaatca ggcaccagga taaaagcagg     2580

gacttaaaca gcaccccggt tcttcagcct gagccatcac atgctatcag tctcctaacc     2640

tccccctggg ccttaagaca gggcttgggc agagaagata aatggtggga caaaaaaatg     2700

agttacattg ccacctgaga aacctcagag gggaggaccc agccttagcc tccctcctcc     2760

caagtgcaaa atgtgtaaac agagtaaacg gaacagaaaa gtgcagtcta agtggttttc     2820

tctcctgccc ctcccaccgc ccctcccccc accccctatt atttggggat aaagaatata     2880

aagacaaccc tggcttttct attgccttgt tgcttgctga atataaggaa tggggtgggg     2940

caggaagggg cttgccctta gccacagctc tacggctgtg cctcattcat ttccacagct     3000

gccagtgtcc ctagagttta tcaggtgaat tggtcagggg atcagtctcc ctcgagcctg     3060

acttacggct gggacagccc catctttctg ttgattatgt ggcgcatata tatatatata     3120

tgtatatata tataatttat ataaatattt ctctatgtaa aaaaaaaaaa aaaaa          3175


<210>  296
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Val Thr Ile 
                165                 170                 175     


Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile Phe Ala Gly Gly 
            180                 185                 190         


Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser Phe Pro His Thr 
        195                 200                 205             


Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly Pro Pro Leu Glu 
    210                 215                 220                 


Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln Pro Asp Leu Thr 
225                 230                 235                 240 


Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe Pro Met Thr His 
                245                 250                 255     


Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser Pro Glu Val Lys 
            260                 265                 270         


Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln Thr Thr Ser His Glu 
        275                 280                 285             


Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly 
    290                 295                 300                 


Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile 
305                 310                 315                 320 


Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val Thr Ile Thr Gly 
                325                 330                 335     


Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile Asn Val Arg Leu 
            340                 345                 350         


Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360         


<210>  297
<211>  1454
<212>  DNA
<213>  Homo sapiens

<400>  297
ggtaaggtgt agctgttctg tcccagtccc cgtagctctg caccgagcag aagaggtcta       60

gggtcacgca ggggccatgg ctgaggcact tgggcttggt tctggcaggc ggagcggacg      120

gggctgagag cggggcccta cgggcggaag aggagcactg gaagaaggaa gagacaaatg      180

ttggggtcta cggattcagt tccagtttaa tgatgtggcc ctctaaggag ataattttgc      240

cttaaacaga aagacttgac cctcttaggt gtcataccta agatcagtgt gttttttgtg      300

tccaattctt ttatcaccaa aaaagagaag aaatattgca gtgaatgaag attcctctgc      360

attttagcac tgctttttca actgtagttg gcttttgaat gaggatgaca atggaagaga      420

tgaagaatga agctgagacc acatccatgg tttctatgcc cctctatgca gtcatgtatc      480

ctgtgtttaa tgagctagaa cgagtaaatc tgtctgcagc ccagacactg agagccgctt      540

tcatcaaggc tgaaaaagaa aatccaggtc tcacacaaga catcattatg aaaattttag      600

agaaaaaaag cgtggaagtt aacttcacgg agtcccttct tcgtatggca gctgatgatg      660

tagaagagta tatgattgaa cgaccagagc cagaattcca agacctaaac gaaaaggcac      720

gagcacttaa acaaattctc agtaagatcc cagatgagat caatgacaga gtgaggtttc      780

tgcagacaat caaggatata gctagtgcaa taaaagaact tcttgataca gtgaataatg      840

tcttcaagaa atatcaatac cagaaccgca gggcacttga acaccaaaag aaagaatttg      900

taaagtactc caaaagtttc agtgatactc tgaaaacgta ttttaaagat ggcaaggcaa      960

taaatgtgtt cgtaagtgcc aaccgactaa ttcatcaaac caacttaata cttcagacct     1020

tcaaaactgt ggcctgaaag ttgtatatgt taagagatgt acttctcagt ggcagtattg     1080

aactgccttt atctgtaaat tttaaagttt gactgtataa attatcagtc cctcctgaag     1140

ggatctaatc caggatgttg aatgggatta ttgccatctt acaccatatt tttgtaaaat     1200

gtagcttaat cataatctca cactgaagat tttgcatcac ttttgctatt atcattcttt     1260

taagaattat aagccaaaag aatttacgcc ttaatgtgtc attatataac attccttaaa     1320

agaattgtaa atattggtgt ttgtttctga cattttaact tgaaagcgat atgctgcaag     1380

ataatgtatt taacaatatt tggtggcaaa tattcaataa atagtttaca tctgttaaaa     1440

aaaaaaaaaa aaaa                                                       1454


<210>  298
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Arg Met Thr Met Glu Glu Met Lys Asn Glu Ala Glu Thr Thr Ser 
1               5                   10                  15      


Met Val Ser Met Pro Leu Tyr Ala Val Met Tyr Pro Val Phe Asn Glu 
            20                  25                  30          


Leu Glu Arg Val Asn Leu Ser Ala Ala Gln Thr Leu Arg Ala Ala Phe 
        35                  40                  45              


Ile Lys Ala Glu Lys Glu Asn Pro Gly Leu Thr Gln Asp Ile Ile Met 
    50                  55                  60                  


Lys Ile Leu Glu Lys Lys Ser Val Glu Val Asn Phe Thr Glu Ser Leu 
65                  70                  75                  80  


Leu Arg Met Ala Ala Asp Asp Val Glu Glu Tyr Met Ile Glu Arg Pro 
                85                  90                  95      


Glu Pro Glu Phe Gln Asp Leu Asn Glu Lys Ala Arg Ala Leu Lys Gln 
            100                 105                 110         


Ile Leu Ser Lys Ile Pro Asp Glu Ile Asn Asp Arg Val Arg Phe Leu 
        115                 120                 125             


Gln Thr Ile Lys Asp Ile Ala Ser Ala Ile Lys Glu Leu Leu Asp Thr 
    130                 135                 140                 


Val Asn Asn Val Phe Lys Lys Tyr Gln Tyr Gln Asn Arg Arg Ala Leu 
145                 150                 155                 160 


Glu His Gln Lys Lys Glu Phe Val Lys Tyr Ser Lys Ser Phe Ser Asp 
                165                 170                 175     


Thr Leu Lys Thr Tyr Phe Lys Asp Gly Lys Ala Ile Asn Val Phe Val 
            180                 185                 190         


Ser Ala Asn Arg Leu Ile His Gln Thr Asn Leu Ile Leu Gln Thr Phe 
        195                 200                 205             


Lys Thr Val Ala 
    210         


<210>  299
<211>  1313
<212>  DNA
<213>  Homo sapiens

<400>  299
gatccgggag ttgaagaggg ctgcaaggtg ggaagtgaag tcagtgcctc agttgctgct       60

ttctcctcta aatcttggtc tcttgtttgg aagtgactaa cagcattttg gcatgagaaa      120

gccctaaaaa gatcagtgtg ttttttgtgt ccaattcttt tatcaccaaa aaagagaaga      180

aatattgcag tgaatgaaga ttcctctgca ttttagcact gctttttcaa ctgtagttgg      240

cttttgaatg aggatgacaa tggaagagat gaagaatgaa gctgagacca catccatggt      300

ttctatgccc ctctatgcag tcatgtatcc tgtgtttaat gagctagaac gagtaaatct      360

gtctgcagcc cagacactga gagccgcttt catcaaggct gaaaaagaaa atccaggtct      420

cacacaagac atcattatga aaattttaga gaaaaaaagc gtggaagtta acttcacgga      480

gtcccttctt cgtatggcag ctgatgatgt agaagagtat atgattgaac gaccagagcc      540

agaattccaa gacctaaacg aaaaggcacg agcacttaaa caaattctca gtaagatccc      600

agatgagatc aatgacagag tgaggtttct gcagacaatc aaggatatag ctagtgcaat      660

aaaagaactt cttgatacag tgaataatgt cttcaagaaa tatcaatacc agaaccgcag      720

ggcacttgaa caccaaaaga aagaatttgt aaagtactcc aaaagtttca gtgatactct      780

gaaaacgtat tttaaagatg gcaaggcaat aaatgtgttc gtaagtgcca accgactaat      840

tcatcaaacc aacttaatac ttcagacctt caaaactgtg gcctgaaagt tgtatatgtt      900

aagagatgta cttctcagtg gcagtattga actgccttta tctgtaaatt ttaaagtttg      960

actgtataaa ttatcagtcc ctcctgaagg gatctaatcc aggatgttga atgggattat     1020

tgccatctta caccatattt ttgtaaaatg tagcttaatc ataatctcac actgaagatt     1080

ttgcatcact tttgctatta tcattctttt aagaattata agccaaaaga atttacgcct     1140

taatgtgtca ttatataaca ttccttaaaa gaattgtaaa tattggtgtt tgtttctgac     1200

attttaactt gaaagcgata tgctgcaaga taatgtattt aacaatattt ggtggcaaat     1260

attcaataaa tagtttacat ctgttaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1313


<210>  300
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Arg Met Thr Met Glu Glu Met Lys Asn Glu Ala Glu Thr Thr Ser 
1               5                   10                  15      


Met Val Ser Met Pro Leu Tyr Ala Val Met Tyr Pro Val Phe Asn Glu 
            20                  25                  30          


Leu Glu Arg Val Asn Leu Ser Ala Ala Gln Thr Leu Arg Ala Ala Phe 
        35                  40                  45              


Ile Lys Ala Glu Lys Glu Asn Pro Gly Leu Thr Gln Asp Ile Ile Met 
    50                  55                  60                  


Lys Ile Leu Glu Lys Lys Ser Val Glu Val Asn Phe Thr Glu Ser Leu 
65                  70                  75                  80  


Leu Arg Met Ala Ala Asp Asp Val Glu Glu Tyr Met Ile Glu Arg Pro 
                85                  90                  95      


Glu Pro Glu Phe Gln Asp Leu Asn Glu Lys Ala Arg Ala Leu Lys Gln 
            100                 105                 110         


Ile Leu Ser Lys Ile Pro Asp Glu Ile Asn Asp Arg Val Arg Phe Leu 
        115                 120                 125             


Gln Thr Ile Lys Asp Ile Ala Ser Ala Ile Lys Glu Leu Leu Asp Thr 
    130                 135                 140                 


Val Asn Asn Val Phe Lys Lys Tyr Gln Tyr Gln Asn Arg Arg Ala Leu 
145                 150                 155                 160 


Glu His Gln Lys Lys Glu Phe Val Lys Tyr Ser Lys Ser Phe Ser Asp 
                165                 170                 175     


Thr Leu Lys Thr Tyr Phe Lys Asp Gly Lys Ala Ile Asn Val Phe Val 
            180                 185                 190         


Ser Ala Asn Arg Leu Ile His Gln Thr Asn Leu Ile Leu Gln Thr Phe 
        195                 200                 205             


Lys Thr Val Ala 
    210         


<210>  301
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  301
tgcaaggtgg gaagtgaagt cagtgcctca gttgctgatc agtgtgtttt ttgtgtccaa       60

ttcttttatc accaaaaaag agaagaaata ttgcagtgaa tgaagattcc tctgcatttt      120

agcactgctt tttcaactgt agttggcttt tgaatgagga tgacaatgga agagatgaag      180

aatgaagctg agaccacatc catggtttct atgcccctct atgcagtcat gtatcctgtg      240

tttaatgagc tagaacgagt aaatctgtct gcagcccaga cactgagagc cgctttcatc      300

aaggctgaaa aagaaaatcc aggtctcaca caagacatca ttatgaaaat tttagagaaa      360

aaaagcgtgg aagttaactt cacggagtcc cttcttcgta tggcagctga tgatgtagaa      420

gagtatatga ttgaacgacc agagccagaa ttccaagacc taaacgaaaa ggcacgagca      480

cttaaacaaa ttctcagtaa gatcccagat gagatcaatg acagagtgag gtttctgcag      540

acaatcaagg atatagctag tgcaataaaa gaacttcttg atacagtgaa taatgtcttc      600

aagaaatatc aataccagaa ccgcagggca cttgaacacc aaaagaaaga atttgtaaag      660

tactccaaaa gtttcagtga tactctgaaa acgtatttta aagatggcaa ggcaataaat      720

gtgttcgtaa gtgccaaccg actaattcat caaaccaact taatacttca gaccttcaaa      780

actgtggcct gaaagttgta tatgttaaga gatgtacttc tcagtggcag tattgaactg      840

cctttatctg taaattttaa agtttgactg tataaattat cagtccctcc tgaagggatc      900

taatccagga tgttgaatgg gattattgcc atcttacacc atatttttgt aaaatgtagc      960

ttaatcataa tctcacactg aagattttgc atcacttttg ctattatcat tcttttaaga     1020

attataagcc aaaagaattt acgccttaat gtgtcattat ataacattcc ttaaaagaat     1080

tgtaaatatt ggtgtttgtt tctgacattt taacttgaaa gcgatatgct gcaagataat     1140

gtatttaaca atatttggtg gcaaatattc aataaatagt ttacatctgt taaaaaaaaa     1200

aaaaaaaaaa aa                                                         1212


<210>  302
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Arg Met Thr Met Glu Glu Met Lys Asn Glu Ala Glu Thr Thr Ser 
1               5                   10                  15      


Met Val Ser Met Pro Leu Tyr Ala Val Met Tyr Pro Val Phe Asn Glu 
            20                  25                  30          


Leu Glu Arg Val Asn Leu Ser Ala Ala Gln Thr Leu Arg Ala Ala Phe 
        35                  40                  45              


Ile Lys Ala Glu Lys Glu Asn Pro Gly Leu Thr Gln Asp Ile Ile Met 
    50                  55                  60                  


Lys Ile Leu Glu Lys Lys Ser Val Glu Val Asn Phe Thr Glu Ser Leu 
65                  70                  75                  80  


Leu Arg Met Ala Ala Asp Asp Val Glu Glu Tyr Met Ile Glu Arg Pro 
                85                  90                  95      


Glu Pro Glu Phe Gln Asp Leu Asn Glu Lys Ala Arg Ala Leu Lys Gln 
            100                 105                 110         


Ile Leu Ser Lys Ile Pro Asp Glu Ile Asn Asp Arg Val Arg Phe Leu 
        115                 120                 125             


Gln Thr Ile Lys Asp Ile Ala Ser Ala Ile Lys Glu Leu Leu Asp Thr 
    130                 135                 140                 


Val Asn Asn Val Phe Lys Lys Tyr Gln Tyr Gln Asn Arg Arg Ala Leu 
145                 150                 155                 160 


Glu His Gln Lys Lys Glu Phe Val Lys Tyr Ser Lys Ser Phe Ser Asp 
                165                 170                 175     


Thr Leu Lys Thr Tyr Phe Lys Asp Gly Lys Ala Ile Asn Val Phe Val 
            180                 185                 190         


Ser Ala Asn Arg Leu Ile His Gln Thr Asn Leu Ile Leu Gln Thr Phe 
        195                 200                 205             


Lys Thr Val Ala 
    210         


<210>  303
<211>  5447
<212>  DNA
<213>  Homo sapiens

<400>  303
gggtggtgca gggcaggggt ggtatatcct gtctgacgga gggcgggcct cgccagtgcc       60

agagagggac gaaccagggt ggaagcgcca ggagcagctg cagggagccc tcacgcggac      120

cacgcactct atggccgtag ggagccgctg agagcgagaa gagcacgctc ctgcccgccc      180

gctgcaccgc acctcgcctc gcctctctgc tctcctaggc cccggccgcg cgccacccgc      240

ctcccgccac catgaaccac tcgccgctca agaccgcctt ggcgtacgaa tgcttccagg      300

accaggacaa ctccacgttg gctttgccgt cggaccaaaa gatgaaaaca ggcacgtctg      360

gcaggcagcg cgtgcaggag caggtgatga tgaccgtcaa gcggcagaag tccaagtctt      420

cccagtcgtc caccctgagc cactccaatc gaggttccat gtatgatggc ttggctgaca      480

attacaacta tgggaccacc agcaggagca gctactactc caagttccag gcagggaatg      540

gctcatgggg atatccgatc tacaatggaa ccctcaagcg ggagcctgac aacaggcgct      600

tcagctccta cagccagatg gagaactgga gccggcacta cccccggggc agctgtaaca      660

ccaccggcgc aggcagcgac atctgcttca tgcagaaaat caaggcgagc cgcagtgagc      720

ccgacctcta ctgtgaccca cggggcaccc tgcgcaaggg cacgctgggc agcaagggcc      780

agaagaccac ccagaaccgc tacagctttt acagcacctg cagtggtcag aaggccataa      840

agaagtgccc tgtgcgcccg ccctcttgtg cctccaagca ggaccctgtg tatatcccgc      900

ccatctcctg caacaaggac ctgtcctttg gccactctag ggccagctcc aagatctgca      960

gtgaggacat cgagtgcagt gggctgacca tccccaaggc tgtgcagtac ctgagctccc     1020

aggatgagaa gtaccaggcc attggggcct attacatcca gcatacctgc ttccaggatg     1080

aatctgccaa gcaacaggtc tatcagctgg gaggcatctg caagctggtg gacctcctcc     1140

gcagccccaa ccagaacgtc cagcaggccg cggcaggggc cctgcgcaac ctggtgttca     1200

ggagcaccac caacaagctg gagacccgga ggcagaatgg gatccgcgag gcagtcagcc     1260

tcctgaggag aaccgggaac gccgagatcc agaagcagct gactgggctg ctctggaacc     1320

tgtcttccac tgacgagctg aaggaggaac tcattgccga cgccctgcct gttctggccg     1380

accgcgtcat cattcccttc tctggctggt gcgatggcaa tagcaacatg tcccgggaag     1440

tggtggaccc tgaggtcttc ttcaatgcca caggctgctt gagaaagaga ctgggcatgc     1500

gggagcttct ggctcttgtt ccgcaaaggg ccactagtag cagggtgaac ctgagctcgg     1560

ccgatgcagg ccgccagacc atgcgtaact actcagggct cattgattcc ctcatggcct     1620

atgtccagaa ctgtgtagcg gccagccgct gtgacgacaa gtctgtggaa aactgcatgt     1680

gtgttctgca caacctctcc taccgcctgg acgccgaggt gcccacccgc taccgccagc     1740

tggagtataa cgcccgcaac gcctacaccg agaagtcctc cactggctgc ttcagcaaca     1800

agagcgacaa gatgatgaac aacaactatg actgccccct gcctgaggaa gagaccaacc     1860

ccaagggcag cggctggttg taccattcag atgccatccg cacctacctg aacctcatgg     1920

gcaagagcaa gaaagatgct accctggagg cctgtgctgg tgccctgcag aacctgacag     1980

ccagcaaggg gctgatgtcc agtggcatga gccagttgat tgggctgaag gaaaagggcc     2040

tgccacaaat tgcccgcctc ctgcaatctg gcaactctga tgtggtgcgg tccggagcct     2100

ccctcctgag caacatgtcc cgccaccctc tgctgcacag agtgatgggg aaccaggtgt     2160

tcccggaggt gaccaggctc ctcaccagcc acactggcaa taccagcaac tccgaagaca     2220

tcttgtcctc ggcctgctac actgtgagga acctgatggc ctcgcagcca caactggcca     2280

agcagtactt ctccagcagc atgctcaaca acatcatcaa cctgtgccga agcagtgcct     2340

cacccaaggc cgcagaagct gcccggcttc tcctgtctga catgtggtcc agcaaggaac     2400

tgcagggtgt cctcagacag caaggtttcg ataggaacat gctgggaacc ttagctgggg     2460

ccaacagcct caggaacttc acctcccgat tctaagaaga gactgtccaa gcaagttagg     2520

cttgcaggaa gatatgaccc agctgagaag ccctcaggcc tcgctggatg gggttttctg     2580

tccatcctgt gcagtatttg ggaaagttca caagaaactg agaagaaacc taaaaactgt     2640

ggatagtgga aagattttta gatttttttt ttccttgggg aaactggcag gcaatggggg     2700

ttagggaggt tggggcgggg ggggctttct tgagttaaag gggcttatat gtgatgtcaa     2760

tatttcttcc tctgagaaat ggtatatata tgtgtataat gtaagtgtgt gcatgcatgt     2820

gcgcgtgcat gtgtgtgtgt gtgagtgtct taaagcataa ccacaaactg caaaaagcta     2880

ggtaagctat tttgttgcag ctcataaggt ggtgaaaagg actctcctgt gtttcttact     2940

cataggcaag gacaacatgt gctttttggt gagctgctca taattcctga aatgtgtggt     3000

gccagggcaa gggggccatc actgcagtca ggccctcaga ggagtcctgc aggcttccta     3060

ccagtggtct ccaggggtgc aggagtaact ggggctgggc cagcctcccc acttacaagg     3120

ctgctttcca ggaagggagg tctggtgtat ctcatgggag aatctggggt gtctgtaatg     3180

tcacccctcc agcagcgcca caaggactga ggttgggtag gtgtggggtt ccagaggaca     3240

gcaggacact ctcgcatact ttgccaaatg aggcctgctc agaggagtag gagctgaaag     3300

atggtgcctt ccaccctctt gggctgtgtg cccatcagag caggctcagc ctgcaaaggc     3360

cctgcattca gaggtcttgt aatctacttg ttgcaggaga aagaaggtaa aaaatgattt     3420

ttttaagaaa agctatttta ttgcagctct ttcccaagag ctgttctggg aatggctggt     3480

cttcatattc ccagtggaga ggggaacaag tggggctggg catataccta ttccggcttc     3540

tagtgggatg gagttggggt atagaaatta accaggaaga tgtttccacc aagcctgctg     3600

tgagtcaatt gagggagtgt ttggggtccc aggagacttg gacgggggga gtttgggtag     3660

actaggaaag gaaagtgcca tatcagggta ccggtaccgg caagctcaca tctcagccag     3720

gggccatgcc ccacttcccc tgaccccagc tgtcttgtct ccactctgtg aaacccacag     3780

gggatgtgat aaacagggct attaggggta tcagccacgt cgagccccca gactctgtgc     3840

acttcagacc agcagcagca ggagggctcc cgagggcctt atgagaaaac ctgtgtggac     3900

atcccttggt gtacactaag acagagcaga gcccagcgct cccaagcctt cctccttcca     3960

gcttctacct ccatgctagc attgctggtg ttagagagga attaacttcc tggtctgtgc     4020

ccttctctag aagaatataa gatgctcctc ctcctcaccc cttctcagcc tcctcccaag     4080

tcttcctctt ctgcaccacc cccgagtcca aacccacctc ttgccccagc attcaggctg     4140

gaaaacactg atgtggactc agtatgataa ctgagatggg ggacgccaga catgtgagga     4200

cgctgtcctc cgagaggtgt ccccggctgt tagccagctg tgctgtggtg ctgtgggtct     4260

gtcataccct cccttgcttc tgttcacact gggaggccca ctcctggctc acctctccct     4320

ctcagggacc cacgtgggag cctggatccc tggactgtcc tgggcatagg tttcaggggc     4380

ctcctttgtt gtcatcagaa cccagaggaa ttcttctcct aaaaaatacg tatggcatac     4440

caatctgtgc ggggcagtgt cctaagcact tagactacat cagggaagaa cacagaccac     4500

atccctgtcc tcatgcggct tatgttttct ggaggaaagt ggagacacaa gtccttggct     4560

ttagggctcc cccggctggg ggctgtgcag tccggtcagg gcgggagggg aaatgcaccg     4620

ctgcatgtga accttaccag cccaggcgga tgccccttcc ccttagcact accctggcct     4680

cctgcatccc ctcgcctcat gttcctccca ccttcaaaga atgaagagcc ccatgggccc     4740

agcccctgcc ctgggaacca ggcagccttc cagacctcag gggctgaggc agactattag     4800

ggcagggctg actttggtga cactgcccat tccctctcag gccagctcag gtcacccggg     4860

cctctgaccc aggcctgtca ctttgagagg ggcaaaactg agaggggctt ttcctagaga     4920

aagagaacaa ggagcttgcc aggcttcatg tagccgacac acgtctcagg attttaagtc     4980

cacattggcc tcacactacc agggccaatg cccaaaataa ggagttccaa tttggggcca     5040

aatgaggaag gacacagact ctgccctggg atctcctgtg ctagcggcca atgacaaatc     5100

cagtcattgg ccaccagcca cctctgcagt ggggaccaca ctagcagccc tgactccaca     5160

ctcctcctgg ggacccaaga ggcagtgttg ctgtctgcat gtccaccttg gaatctggct     5220

gaactggctg gcaggaccaa gactgcggct ggggtgggca gggaagggaa gccgggggct     5280

gctgtgaggg atcttggagc ttccctgtag cccaccttcc ccttgcttca tgtttgtaga     5340

ggaaccttgt gccggccagg cccagtttcc ttgtgtgata cactaatgta tttgcttttt     5400

ttggaaatag agaaaatcaa taaattgcta gtgtttcttt gaacttt                   5447


<210>  304
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Lys Arg Leu Gly Met 
                405                 410                 415     


Arg Glu Leu Leu Ala Leu Val Pro Gln Arg Ala Thr Ser Ser Arg Val 
            420                 425                 430         


Asn Leu Ser Ser Ala Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser 
        435                 440                 445             


Gly Leu Ile Asp Ser Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala 
    450                 455                 460                 


Ser Arg Cys Asp Asp Lys Ser Val Glu Asn Cys Met Cys Val Leu His 
465                 470                 475                 480 


Asn Leu Ser Tyr Arg Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln 
                485                 490                 495     


Leu Glu Tyr Asn Ala Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly 
            500                 505                 510         


Cys Phe Ser Asn Lys Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys 
        515                 520                 525             


Pro Leu Pro Glu Glu Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr 
    530                 535                 540                 


His Ser Asp Ala Ile Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys 
545                 550                 555                 560 


Lys Asp Ala Thr Leu Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr 
                565                 570                 575     


Ala Ser Lys Gly Leu Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu 
            580                 585                 590         


Lys Glu Lys Gly Leu Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn 
        595                 600                 605             


Ser Asp Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg 
    610                 615                 620                 


His Pro Leu Leu His Arg Val Met Gly Asn Gln Val Phe Pro Glu Val 
625                 630                 635                 640 


Thr Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp 
                645                 650                 655     


Ile Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln 
            660                 665                 670         


Pro Gln Leu Ala Lys Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile 
        675                 680                 685             


Ile Asn Leu Cys Arg Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala 
    690                 695                 700                 


Arg Leu Leu Leu Ser Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val 
705                 710                 715                 720 


Leu Arg Gln Gln Gly Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly 
                725                 730                 735     


Ala Asn Ser Leu Arg Asn Phe Thr Ser Arg Phe 
            740                 745         


<210>  305
<211>  5388
<212>  DNA
<213>  Homo sapiens

<400>  305
gggtggtgca gggcaggggt ggtatatcct gtctgacgga gggcgggcct cgccagtgcc       60

agagagggac gaaccagggt ggaagcgcca ggagcagctg cagggagccc tcacgcggac      120

ctcgcactct atggccgtag ggagccgctg agagcgagaa gagcacgctc ctgcccgccc      180

gctgcaccgc acctcgcctc gcctctctgc tctcctaggc cccggccgcg cgccacccgc      240

ctcccgccac catgaaccac tcgccgctca agaccgcctt ggcgtacgaa tgcttccagg      300

accaggacaa ctccacgttg gctttgccgt cggaccaaaa gatgaaaaca ggcacgtctg      360

gcaggcagcg cgtgcaggag caggtgatga tgaccgtcaa gcggcagaag tccaagtctt      420

cccagtcgtc caccctgagc cactccaatc gaggttccat gtatgatggc ttggctgaca      480

attacaacta tgggaccacc agcaggagca gctactactc caagttccag gcagggaatg      540

gctcatgggg atatccgatc tacaatggaa ccctcaagcg ggagcctgac aacaggcgct      600

tcagctccta cagccagatg gagaactgga gccggcacta cccccggggc agctgtaaca      660

ccaccggcgc aggcagcgac atctgcttca tgcagaaaat caaggcgagc cgcagtgagc      720

ccgacctcta ctgtgaccca cggggcaccc tgcgcaaggg cacgctgggc agcaagggcc      780

agaagaccac ccagaaccgc tacagctttt acagcacctg cagtggtcag aaggccataa      840

agaagtgccc tgtgcgcccg ccctcttgtg cctccaagca ggaccctgtg tatatcccgc      900

ccatctcctg caacaaggac ctgtcctttg gccactctag ggccagctcc aagatctgca      960

gtgaggacat cgagtgcagt gggctgacca tccccaaggc tgtgcagtac ctgagctccc     1020

aggatgagaa gtaccaggcc attggggcct attacatcca gcatacctgc ttccaggatg     1080

aatctgccaa gcaacaggtc tatcagctgg gaggcatctg caagctggtg gacctcctcc     1140

gcagccccaa ccagaacgtc cagcaggccg cggcaggggc cctgcgcaac ctggtgttca     1200

ggagcaccac caacaagctg gagacccgga ggcagaatgg gatccgcgag gcagtcagcc     1260

tcctgaggag aaccgggaac gccgagatcc agaagcagct gactgggctg ctctggaacc     1320

tgtcttccac tgacgagctg aaggaggaac tcattgccga cgccctgcct gttctggccg     1380

accgcgtcat cattcccttc tctggctggt gcgatggcaa tagcaacatg tcccgggaag     1440

tggtggaccc tgaggtcttc ttcaatgcca caggctgctt gaggaacctg agctcggccg     1500

atgcaggccg ccagaccatg cgtaactact cagggctcat tgattccctc atggcctatg     1560

tccagaactg tgtagcggcc agccgctgtg acgacaagtc tgtggaaaac tgcatgtgtg     1620

ttctgcacaa cctctcctac cgcctggacg ccgaggtgcc cacccgctac cgccagctgg     1680

agtataacgc ccgcaacgcc tacaccgaga agtcctccac tggctgcttc agcaacaaga     1740

gcgacaagat gatgaacaac aactatgact gccccctgcc tgaggaagag accaacccca     1800

agggcagcgg ctggttgtac cattcagatg ccatccgcac ctacctgaac ctcatgggca     1860

agagcaagaa agatgctacc ctggaggcct gtgctggtgc cctgcagaac ctgacagcca     1920

gcaaggggct gatgtccagt ggcatgagcc agttgattgg gctgaaggaa aagggcctgc     1980

cacaaattgc ccgcctcctg caatctggca actctgatgt ggtgcggtcc ggagcctccc     2040

tcctgagcaa catgtcccgc caccctctgc tgcacagagt gatggggaac caggtgttcc     2100

cggaggtgac caggctcctc accagccaca ctggcaatac cagcaactcc gaagacatct     2160

tgtcctcggc ctgctacact gtgaggaacc tgatggcctc gcagccacaa ctggccaagc     2220

agtacttctc cagcagcatg ctcaacaaca tcatcaacct gtgccgaagc agtgcctcac     2280

ccaaggccgc agaagctgcc cggcttctcc tgtctgacat gtggtccagc aaggaactgc     2340

agggtgtcct cagacagcaa ggtttcgata ggaacatgct gggaacctta gctggggcca     2400

acagcctcag gaacttcacc tcccgattct aagaagagac tgtccaagca agttaggctt     2460

gcaggaagat atgacccagc tgagaagccc tcaggcctcg ctggatgggg ttttctgtcc     2520

atcctatgca gtatttggga aagttcacaa gaaactgaga agaaacctaa aaactgtgga     2580

tagtggaaag atttttagat tttttttttc cttggggaaa ctggcaggca atgggggtta     2640

gggaggttgg ggcggtgggg gctttcttga gttaaagggg cttatatgtg atgtcaatat     2700

ttcttcctct gagaaatggt atatatatgt gtataatgta agtgtgtgca tgcatgtgcg     2760

cgtgcatgtg tgtgtgtgtg agtgtcttaa agcataacca caaactgcaa aaagctaggt     2820

aagctatttt gttgcagctc ataaggtggt gaaaaggact ctcctgtgtt tcttactcat     2880

aggcaaggac aacatgtgct ttttggtgag ctgctcataa ttcctgaaat gtgtggtgcc     2940

agggcaaggg ggccatcact gcagtcaggc cctcagagga gtcctgcagg cttcctacca     3000

gtggtctcca ggggtgcagg agtaactggg gctgggccag cctccccact tacaaggctg     3060

ctttccagga agggaggtct ggtgtatctc atgggagaat ctggggtgtc tgtaatgtca     3120

cccctccagc agcgccacaa ggactgaggt tgggtaggtg tggggttcca gaggacagca     3180

ggacactctc gcatactttg ccaaatgagg cctgctcaga ggagtaggag ctgaaagatg     3240

gtgccttcca ccctcttggg ctgtgtgccc atcagagcag gctcagcctg caaaggccct     3300

gcattcagag gtcttgtaat ctacttgttg caggagaaag aaggtaaaaa atgatttttt     3360

taagaaaagc tattttattg cagctctttc ccaagagctg ttctgggaat ggctggtctt     3420

catattccca gtggagaggg gaacaagtgg ggctgggcat atacctattc cggcttctag     3480

tgggatggag ttggggtata gaaattaacc aggaagatgt ttccaccaag cctgctgtga     3540

gtcaattgag ggagtgtttg gggtcccagg agacttggac ggggggagtt tgggtagact     3600

aggaaaggaa agtgccatat cagggtaccg gtaccggcaa gctcacatct cagccagggg     3660

ccatgcccca cttcccctga ccccagctgt cttgtctcca ctctgtgaaa cccacagggg     3720

atgtgataaa cagggctatt aggggtatca gccacgtcga gcccccagac tctgtgcact     3780

tcagaccagc agcagcagga gggctcccga gggccttatg agaaaacctg tgtggacatc     3840

ccttggtgta cactaagaca gagcagagcc cagcgctccc aagccttcct ccttccagct     3900

tctacctcca tgctagcatt gctggtgtta gagaggaatt aacttcctgg tctgtgccct     3960

tctctagaag aatataagat gctcctcctc ctcacccctt ctcagcctcc tcccaagtct     4020

tcctcttctg caccaccccc gagtccaaac ccacctcttg ccccagcatt caggctggaa     4080

aacactgatg tggactcagt atgataactg agatggggga cgccagacat gtgaggacgc     4140

tgtcctccga gaggtgtccc cggctgttag ccagctgtgc tgtggtgctg tgggtctgtc     4200

ataccctccc ttgcttctgt tcacactggg aggcccactc ctggctcacc tctccctctc     4260

agggacccac gtgggagcct ggatccctgg actgtcctgg gcataggttt caggggcctc     4320

ctttgttgtc atcagaaccc agaggaattc ttctcctaaa aaatacgtat ggcataccaa     4380

tctgtgcggg gcagtgtcct aagcacttag actacatcag ggaagaacac agaccacatc     4440

cctgtcctca tgcggcttat gttttctgga ggaaagtgga gacacaagtc cttggcttta     4500

gggctccccc ggctgggggc tgtgcagtcc ggtcagggcg ggaggggaaa tgcaccgctg     4560

catgtgaacc ttaccagccc aggcggatgc cccttcccct tagcactacc ctggcctcct     4620

gcatcccctc gcctcatgtt cctcccacct tcaaagaatg aagagcccca tgggcccagc     4680

ccctgccctg ggaaccaggc agccttccag acctcagggg ctgaggcaga ctattagggc     4740

agggctgact ttggtgacac tgcccattcc ctctcaggcc agctcaggtc acccgggcct     4800

ctgacccagg cctgtcactt tgagaggggc aaaactgaga ggggcttttc ctagagaaag     4860

agaacaagga gcttgccagg cttcatgtag ccgacacacg tctcaggatt ttaagtccac     4920

attggcctca cactaccagg gccaatgccc aaaataagga gttccaattt ggggccaaat     4980

gaggaaggac acagactctg ccctgggatc tcctgtgcta gcggccaatg acaaatccag     5040

tcattggcca ccagccacct ctgcagtggg gaccacacta gcagccctga ctccacactc     5100

ctcctgggga cccaagaggc agtgttgctg tctgcatgtc caccttggaa tctggctgaa     5160

ctggctggca ggaccaagac tgcggctggg gtgggcaggg aagggaagcc gggggctgct     5220

gtgagggatc ttggagcttc cctgtagccc accttcccct tgcttcatgt ttgtagagga     5280

accttgtgcc ggccaggccc agtttccttg tgtgatacac taatgtattt gctttttttg     5340

gaaatagaga aaatcaataa attgctagtg tttctttgaa aaaaaaaa                  5388


<210>  306
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Asn Leu Ser Ser Ala 
                405                 410                 415     


Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser Gly Leu Ile Asp Ser 
            420                 425                 430         


Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala Ser Arg Cys Asp Asp 
        435                 440                 445             


Lys Ser Val Glu Asn Cys Met Cys Val Leu His Asn Leu Ser Tyr Arg 
    450                 455                 460                 


Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln Leu Glu Tyr Asn Ala 
465                 470                 475                 480 


Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly Cys Phe Ser Asn Lys 
                485                 490                 495     


Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys Pro Leu Pro Glu Glu 
            500                 505                 510         


Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr His Ser Asp Ala Ile 
        515                 520                 525             


Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys Lys Asp Ala Thr Leu 
    530                 535                 540                 


Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr Ala Ser Lys Gly Leu 
545                 550                 555                 560 


Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu Lys Glu Lys Gly Leu 
                565                 570                 575     


Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn Ser Asp Val Val Arg 
            580                 585                 590         


Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg His Pro Leu Leu His 
        595                 600                 605             


Arg Val Met Gly Asn Gln Val Phe Pro Glu Val Thr Arg Leu Leu Thr 
    610                 615                 620                 


Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp Ile Leu Ser Ser Ala 
625                 630                 635                 640 


Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln Pro Gln Leu Ala Lys 
                645                 650                 655     


Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile Ile Asn Leu Cys Arg 
            660                 665                 670         


Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala Arg Leu Leu Leu Ser 
        675                 680                 685             


Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val Leu Arg Gln Gln Gly 
    690                 695                 700                 


Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly Ala Asn Ser Leu Arg 
705                 710                 715                 720 


Asn Phe Thr Ser Arg Phe 
                725     


<210>  307
<211>  5728
<212>  DNA
<213>  Homo sapiens

<400>  307
ccgggacaga ctggcgggcg ggcgggcact gacgccgcgg ggccggagcg ggccgcgcgg       60

tgggagcagc ggcgccgtcg gtccccgtca gggctccgtg ggtccccgac ccgcccctgg      120

ccgggccatg gcgggcgccc agcccggcgt ccacgcgctg cagttggagc cgcccaccgt      180

ggtggagacc ctgcggcgcg ggagtaagtt catcaaatgg gacgaggaga cctccagtcg      240

gaacctggtg accctgcgtg tggaccccaa tggcttcttc ttgtactgga cgggccccaa      300

catggaggtg gacacactgg acatcagttc catcagggac acacggacag gccggtacgc      360

ccgcctgccc aaggacccca agatccggga agttctgggc tttgggggtc ccgatgcccg      420

gctggaggag aagctgatga cggtggtgtc tgggccagac ccagtgaaca cagtgttctt      480

gaacttcatg gccgtgcagg atgacacagc caaggtctgg tctgaggagc tattcaagct      540

ggctatgaac atcctggctc agaacgcctc ccggaacacc ttcctgcgca aagcatacac      600

gaagctgaag ctgcaggtga accaggatgg tcggatcccc gtcaagaaca tcctgaagat      660

gttctcagca gacaagaagc gggtggagac tgcgctggaa tcctgtggcc tcaaattcaa      720

ccggagtgag tccatccggc ctgatgagtt ttccttggaa atctttgagc ggttcctgaa      780

caagctgtgt ctgcggccgg acattgacaa gatcctgctg gagataggcg ccaagggcaa      840

gccatacctg acgctggagc agctcatgga cttcatcaac cagaagcaac gcgacccgag      900

actcaacgaa gtgctgtacc cgcccctgcg gccctcccag gcccggctgc tcatcgaaaa      960

gtatgagccc aaccagcagt ttctggagcg agaccagatg tccatggagg gctttagccg     1020

ctacctggga ggcgaggaga atggcatcct gcccctggaa gccctggatc tgagcacgga     1080

catgacccag ccactgagtg cctacttcat caactcctcg cataacacct atctcactgc     1140

ggggcagctg gctgggacct cgtcggtgga gatgtaccgc caggcactac tatggggctg     1200

ccgctgcgtg gagctggacg tgtggaaggg acggccgcct gaggaggaac ccttcattac     1260

ccacggcttc accatgacca cagaggtgcc tctgcgcgac gtgctggagg ccattgccga     1320

gactgccttc aagacctcgc cctaccccgt catcctctcc ttcgagaacc atgtggactc     1380

ggcaaagcaa caggcaaaga tggctgagta ctgccgctcc atctttggag acgcgctact     1440

catcgagcct ctggacaagt acccgctggc cccaggcgtt cccctgccca gcccccagga     1500

cctgatgggc cgtatcctgg tgaagaacaa gaagcggcac cgacccagcg caggtggccc     1560

agacagcgcc gggcgcaagc ggcccctgga gcagagcaat tctgccctga gcgagagctc     1620

cgcggccacc gagccctcct ccccgcagct ggggtctccc agctctgaca gctgcccagg     1680

cctgagcaat ggggaggagg tagggcttga gaagcccagc ctggagcctc agaagtctct     1740

gggtgacgag ggcctgaacc gaggccccta tgttcttgga cctgctgacc gtgaggatga     1800

ggaggaagat gaggaagagg aggaacagac agaccccaaa aagccaacta cagatgaggg     1860

cacagccagc agcgaggtga atgccactga ggagatgtcc acgcttgtca actacatcga     1920

acctgtcaag ttcaagtcct ttgaggctgc tcgaaagagg aacaaatgct tcgagatgtc     1980

gtcctttgtg gagaccaagg ccatggagca actgaccaag agccccatgg agtttgtgga     2040

atacaacaag cagcagctca gccgcatcta ccccaagggc acccgcgtgg actcctccaa     2100

ctacatgccc cagctcttct ggaacgtagg gtgccagctt gttgcgctca acttccagac     2160

cctcgatgtg gcgatgcagc tcaacgcggg cgtttttgag tacaacgggc gcagcgggta     2220

cctgctcaag ccggagttca tgcggcggcc ggacaagtcc ttcgacccct tcactgaggt     2280

catcgtggat ggcatcgtgg ccaatgcctt gcgggtcaag gtgatctcag ggcagttcct     2340

gtccgacagg aaggtgggca tctacgtgga ggtggacatg tttggcctcc ctgttgatac     2400

gcggcgcaag taccgcaccc ggacctctca ggggaactcg ttcaaccccg tgtgggacga     2460

agagcccttc gacttcccca aggtggtgct gcccacgctg gcttcacttc gcattgcagc     2520

ctttgaggag gggggtaaat tcgtagggca ccggatcctg cctgtctctg ccatccgctc     2580

cggataccac tacgtctgcc tgcggaacga ggccaaccaa ccgctgtgcc tgccggccct     2640

gctcatctac accgaagcct cggactacat tcctgacgac caccaggact atgcggaggc     2700

cctgatcaac cccattaagc acgtcagcct gatggaccag agggcccggc agctggccgc     2760

cctcattggg gagagtgagg ctcaggctgg ccaagagacg tgccaggaca cccagtctca     2820

gcagctgggg tctcagccgt cctcaaaccc cacccccagc ccactggatg cctccccccg     2880

ccggccccct ggccccacca cctcccctgc cagcacctcc ctcagcagcc cagggcagcg     2940

tgatgatctc atcgccagca tcctctcaga ggtggccccc accccgctgg atgagctccg     3000

aggtcacaag gctctggtca agctccggag ccggcaagag cgagacctgc gggagctgcg     3060

caagaagcat cagcggaagg cagtcaccct cacccgccgc ctgctggatg gcctggctca     3120

ggcacaggct gagggcaggt gccggctgcg gccaggtgcc ctaggtgggg ccgctgatgt     3180

ggaggacacg aaggaggggg aggacgaggc aaagcggtat caggagttcc agaacagaca     3240

ggtgcagagc ctgctggagc tgcgggaggc ccaggtggac gcagaggccc agcggaggct     3300

ggaacacctg agacaggctc tgcagcggct cagggaggtc gtccttgatg caaacacaac     3360

tcagttcaag aggctgaaag agatgaacga gagggagaag aaggagctgc agaagatcct     3420

ggacagaaag cgccataaca gcatctcgga ggccaagatg agggacaagc ataagaagga     3480

ggcggaactg acggagatta accgtcggca catcactgag tcagtcaact ccatccgtcg     3540

gctggaggag gcccagaagc agcggcatga ccgtcttgtg gctgggcagc agcaggtcct     3600

gcaacagctg gcagaagagg agcccaagct gctggcccag ctggcccagg agtgtcagga     3660

gcagcgggcg aggctccccc aggagatccg ccggagcctg ctgggcgaga tgccggaggg     3720

gctgggggac gggcctctgg tggcctgtgc cagcaacggt cacgcacccg ggagcagcgg     3780

gcacctgtcg ggcgctgact cggagagcca ggaggagaac acgcagctct gaactggctg     3840

agcgaggtgg ccacagggcc agggcgggcg ctgggtggag ggcaggaggc aatgacacta     3900

atgctttttt tttttttttt taacttttta tctagaaatt ttattttttt aaacccgggg     3960

caagtacctc agctaactcc cttcatcctc ctggggcccc tccttcctgc cctcagtctt     4020

aggttagggc cttggtcagg gctttgctcc ctgtgacacc cacaccctcg agctagcagc     4080

gtctcctccc ttccccggga gagctggctg gagacttgga gctccgggaa gtaggagtca     4140

catttttttc tctattcttt ggggattttt tttacatgaa taaaagtgga tttcagggac     4200

cctgtgtgca gtgtgatttg gggtgacagg actctgggcc ctaagtttcc tcatctataa     4260

aatggacttt gggcatttgg tggggttgag gtcacgcctc cagccaaggg ctgctgggtt     4320

gaacctgagc ttgccctgcc gagtctgctg agcttccgtg gccttctgct tgtgccctct     4380

gcccccaagc cgctgttcct gttcccccat ccccatgact ttcgtctctc cgaggctctc     4440

cctgttctct cttttctgag gctcaggcct ctgcttcagg aagccttccc tgccccgctt     4500

cctgtggcct gatatgaccc aaacgcctag tatcttccgc tggggctgct ctgggccccc     4560

gacaggcagt tgactctatc aggtgatgga tcggccaggg tggagcaggg cagctcagaa     4620

cctgcccaac accgggggac ctgggtcttc agaaataggt gggcagtagg cctgcctgtg     4680

actctggggg aagggaagtg gacagtcaca gacacgcagg ggctgggcca cccagcatcc     4740

cctcatccct gtgagggaga tgttatgcct gttttacaga tgaggagact gaggcccgga     4800

gccatctgtc gtgtgctagg ccacagctaa gtcaagacgt cctgacctgg aggcagggca     4860

ggcctggacc ctccgtggtg gactgtcttc agccagcctg gacctgtccc atgcctcaag     4920

accagcgaaa agtggcagag agcccacagt gcgggctcca gggcggggct gggctcgcag     4980

cagggtcggc ttggcacctc ttcaaggcct ctcccagctt cctggctctt cccaggctgc     5040

ccgcctgcat ccctcctcca ggggaaggcg gcctcttatc tgggcttatc tcctgccaat     5100

tgagtatctt ctttgctttg tttttgctgc agcctcaggc aaacagatgg ggtggggagg     5160

ccagggaaac aggctccgga gtagggccct cctccctcag ggtcaatgca atggccccag     5220

acttcctcac ttcttctgtg ggacgctgcc ctatccccca gttctgctca ctccagtgta     5280

ttccgtatct aggctcctca gcagccaact cccaccttcc tgactctagc tggtgtccac     5340

tgagggacac actccaagtc agttcccagg tcctcaaata ccagctgaat gtctaacttc     5400

tgggtgtgac attccagccc ctagaagcct ggcctctgct gctcccctgt ccttccatgg     5460

gtccactcct ccttgcgccg ggggggatga ccctcacctc accttccggt cgcagctcta     5520

gctgcctcct ccctgaagcc ctctctgact gccctgccga ttccgggccc tcgggagctt     5580

ccgcgagcag ggccgtggcg caatgcatct ctgtgcccgg caccaagaac cggcccgggt     5640

tatagggggc gccaataaat ctttctggaa cggagccccc gctctgtccg ggtccccgca     5700

tgaagcctca gtttccagcg accgcgct                                        5728


<210>  308
<211>  1234
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
1               5                   10                  15      


Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
            20                  25                  30          


Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
        35                  40                  45              


Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
    50                  55                  60                  


Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
65                  70                  75                  80  


Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                85                  90                  95      


Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
            100                 105                 110         


Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
        115                 120                 125             


Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
    130                 135                 140                 


Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
145                 150                 155                 160 


Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                165                 170                 175     


Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
            180                 185                 190         


Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
        195                 200                 205             


Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
    210                 215                 220                 


Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
225                 230                 235                 240 


Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                245                 250                 255     


Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
            260                 265                 270         


Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
        275                 280                 285             


Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
    290                 295                 300                 


Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
305                 310                 315                 320 


Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                325                 330                 335     


Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
            340                 345                 350         


Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
        355                 360                 365             


Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
    370                 375                 380                 


Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
385                 390                 395                 400 


Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                405                 410                 415     


Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
            420                 425                 430         


Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
        435                 440                 445             


Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
    450                 455                 460                 


Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
465                 470                 475                 480 


Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                485                 490                 495     


Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
            500                 505                 510         


Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
        515                 520                 525             


Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
    530                 535                 540                 


Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
545                 550                 555                 560 


Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                565                 570                 575     


Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
            580                 585                 590         


Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
        595                 600                 605             


Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
    610                 615                 620                 


Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
625                 630                 635                 640 


Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                645                 650                 655     


Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
            660                 665                 670         


Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
        675                 680                 685             


Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
    690                 695                 700                 


Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
705                 710                 715                 720 


Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                725                 730                 735     


Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
            740                 745                 750         


Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
        755                 760                 765             


Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
    770                 775                 780                 


Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
785                 790                 795                 800 


Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                805                 810                 815     


Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
            820                 825                 830         


Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
        835                 840                 845             


Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
    850                 855                 860                 


His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
865                 870                 875                 880 


Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                885                 890                 895     


Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
            900                 905                 910         


Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
        915                 920                 925             


Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
    930                 935                 940                 


Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
945                 950                 955                 960 


Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                965                 970                 975     


Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
            980                 985                 990         


Leu Asp Gly Leu Ala Gln Ala Gln  Ala Glu Gly Arg Cys  Arg Leu Arg 
        995                 1000                 1005             


Pro Gly  Ala Leu Gly Gly Ala  Ala Asp Val Glu Asp  Thr Lys Glu 
    1010                 1015                 1020             


Gly Glu  Asp Glu Ala Lys Arg  Tyr Gln Glu Phe Gln  Asn Arg Gln 
    1025                 1030                 1035             


Val Gln  Ser Leu Leu Glu Leu  Arg Glu Ala Gln Val  Asp Ala Glu 
    1040                 1045                 1050             


Ala Gln  Arg Arg Leu Glu His  Leu Arg Gln Ala Leu  Gln Arg Leu 
    1055                 1060                 1065             


Arg Glu  Val Val Leu Asp Ala  Asn Thr Thr Gln Phe  Lys Arg Leu 
    1070                 1075                 1080             


Lys Glu  Met Asn Glu Arg Glu  Lys Lys Glu Leu Gln  Lys Ile Leu 
    1085                 1090                 1095             


Asp Arg  Lys Arg His Asn Ser  Ile Ser Glu Ala Lys  Met Arg Asp 
    1100                 1105                 1110             


Lys His  Lys Lys Glu Ala Glu  Leu Thr Glu Ile Asn  Arg Arg His 
    1115                 1120                 1125             


Ile Thr  Glu Ser Val Asn Ser  Ile Arg Arg Leu Glu  Glu Ala Gln 
    1130                 1135                 1140             


Lys Gln  Arg His Asp Arg Leu  Val Ala Gly Gln Gln  Gln Val Leu 
    1145                 1150                 1155             


Gln Gln  Leu Ala Glu Glu Glu  Pro Lys Leu Leu Ala  Gln Leu Ala 
    1160                 1165                 1170             


Gln Glu  Cys Gln Glu Gln Arg  Ala Arg Leu Pro Gln  Glu Ile Arg 
    1175                 1180                 1185             


Arg Ser  Leu Leu Gly Glu Met  Pro Glu Gly Leu Gly  Asp Gly Pro 
    1190                 1195                 1200             


Leu Val  Ala Cys Ala Ser Asn  Gly His Ala Pro Gly  Ser Ser Gly 
    1205                 1210                 1215             


His Leu  Ser Gly Ala Asp Ser  Glu Ser Gln Glu Glu  Asn Thr Gln 
    1220                 1225                 1230             


Leu 
    


<210>  309
<211>  8412
<212>  DNA
<213>  Homo sapiens

<400>  309
agccgcgtca acggcccttc gcagcgggcg cgctgtcaga cctcagtctg gcggctgcat       60

tgctgggcgc gccgctctcg tctgatccct gctggggacg gttgcccggg caggatcctt      120

tacgatccct tctcggtttc tccgtcgtca cagggaataa atctcgctcg aaactcactg      180

gaccgctcct agaaaggcga aaagatattc aggagccctt ccattttcct tccagtaggc      240

accgaaccca gcattttcgg caaccgctgc tggcagtttt gccaggtgtt tgttaccttg      300

aaaaatggct actggacagg atcgagtggt tgctctcgtg gacatggact gtttttttgt      360

tcaagtggag cagcggcaaa atcctcattt gaggaataaa ccttgtgcag ttgtacagta      420

caaatcatgg aagggtggtg gaataattgc agtgagttat gaagctcgtg catttggagt      480

cactagaagt atgtgggcag atgatgctaa gaagttatgt ccagatcttc tactggcaca      540

agttcgtgag tcccgtggga aagctaacct caccaagtac cgggaagcca gtgttgaagt      600

gatggagata atgtctcgtt ttgctgtgat tgaacgtgcc agcattgatg aggcttacgt      660

agatctgacc agtgctgtac aagagagact acaaaagcta caaggtcagc ctatctcggc      720

agacttgttg ccaagcactt acattgaagg gttgccccaa ggccctacaa cggcagaaga      780

gactgttcag aaagagggga tgcgaaaaca aggcttattt caatggctcg attctcttca      840

gattgataac ctcacctctc cagacctgca gctcaccgtg ggagcagtga ttgtggagga      900

aatgagagca gccatagaga gggagactgg ttttcagtgt tcagctggaa tttcacacaa      960

taaggtcctg gcaaaactgg cctgtggact aaacaagccc aaccgccaaa ccctggtttc     1020

acatgggtca gtcccacagc tcttcagcca aatgcccatt cgcaaaatcc gtagtcttgg     1080

aggaaagcta ggggcctctg tcattgagat cctagggata gaatacatgg gtgaactgac     1140

ccagttcact gaatcccagc tccagagtca ttttggggag aagaatgggt cttggctata     1200

tgccatgtgc cgagggattg aacatgatcc agttaaaccc aggcaactac ccaaaaccat     1260

tggctgtagt aagaacttcc caggaaaaac agctcttgct actcgggaac aggtacaatg     1320

gtggctgttg caattagccc aggaactaga ggagagactg actaaagacc gaaatgataa     1380

tgacagggta gccacccagc tggttgtgag cattcgtgta caaggagaca aacgcctcag     1440

cagcctgcgc cgctgctgtg cccttacccg ctatgatgct cacaagatga gccatgatgc     1500

atttactgtc atcaagaact gtaatacttc tggaatccag acagaatggt ctcctcctct     1560

cacaatgctt ttcctctgtg ctacaaaatt ttctgcctct gccccttcat cttctacaga     1620

catcaccagc ttcttgagca gtgacccaag ttctctgcca aaggtgccag ttaccagctc     1680

agaagctaag acccagggaa gtggcccagc ggtgacagcc actaagaaag caaccacgtc     1740

tctggaatca ttcttccaaa aagctgcaga aaggcagaaa gttaaagaag cttcgctttc     1800

atctcttact gctcccactc aggctcccat gagcaattca ccatccaagc cctcattacc     1860

ttttcaaacc agtcaaagta caggaactga gcccttcttt aagcagaaaa gtctgcttct     1920

aaagcagaaa cagcttaata attcttcagt ttcttccccc caacaaaacc catggtccaa     1980

ctgtaaagca ttaccaaact ctttaccaac agagtatcca gggtgtgtcc ctgtttgtga     2040

aggggtgtcg aagctagaag aatcctctaa agcaactcct gcagagatgg atttggccca     2100

caacagccaa agcatgcacg cctcttcagc ttccaaatct gtgctggagg tgactcagaa     2160

agcaacccca aatccaagtc ttctagctgc tgaggaccaa gtgccctgtg agaagtgtgg     2220

ctccctggta ccggtatggg atatgccaga acacatggac tatcattttg cattggagtt     2280

gcagaaatcc tttttgcagc cccactcttc aaacccccag gttgtttctg ccgtatctca     2340

tcaaggcaaa agaaatccca agagcccttt ggcctgcact aataaacgcc ccaggcctga     2400

gggcatgcaa acattggaat cattttttaa gccattaaca cattagtgct gccctcaggc     2460

ttgcctgtag gatttaatat tttttatctt tacagatctt tatctttaat attttatctt     2520

tacagatttc cctgagaaag ggaattatga aatttttaat acaaaaaata atccatttag     2580

gtgctgagtt acggtcccat ctcttcacag gcatggattc taatcccact gctgacagag     2640

atgtaaaaat tcatcctacc agagttttta atctttagca tttagggagg cagtgtcata     2700

aagtaaaaag tgtgtgggcc ttggagtcta agagacgtgg ttgcaaactt agctctggtt     2760

attgcaatga gggccttgaa caagtcattt tcttcacatt ctcatctgta aaatggagat     2820

aataccttac agattattgc agattaataa caatgtattc aaattatgta actcggccgg     2880

gtacaatggc tcacgcctgt aatcctaaca ctttgggagg ccgaggcaga cagatcacct     2940

gaggtcagga gtttgagacc agcctggcca acatggcaaa accatctcta ctaaaaatag     3000

aaaaattagc caggcacgtt ccaggcacct gtgatcccag ctacttagag gctgaggcag     3060

aagaattgct ttaaccttgg aggcggaggt tgcattgagc tgagatcatg ctagtgcgct     3120

ccagcctggg caacagagcg agacttcatc tcagaaaata aaaaataggg gccaggcaca     3180

gtggctcata cctgtaatgc cagcactttg ggaggccaag gcgggcagat cacgaggtca     3240

ggagtttcag accaatatgg tgaaacccca tctctactaa aattacaaaa aaaattatcc     3300

aggcgtggtg gtgcacgcct gtaatcccag ctactcagga ggctaaggca ggagaatcac     3360

ttgaacccag gaggcagagg ttggagtgag ctgagatcgc gccaccgcac tccagcctgg     3420

gcaacagagc gagactccat ctcaaacaaa aacaagaaca aaaacaaaca taaagttggc     3480

acagaaaagg gaccaagttt aaaaaagggt tttaaatgta atgagacttg catagttaaa     3540

aaaaaaaaag ggattatttt tatttttatt ttttattttt gagacggagt ctccctctgt     3600

cgtcaggcta gaatgcagtg gtgcgttctc agctcaccgc aacctccgtc tcctgggttc     3660

aagcaattct cctgcctcag cctcccaagt agctgggact acaggcacgt gctaccacac     3720

tcagctaatt tttgtatttt taatagagat gaggtttcac catgttggcc aggatggtct     3780

cgattgcttg acctcatgat ccgcctgcct cgacctccca aagttgctgg gattacagat     3840

gttagccacc gatcctggcc cccccaaaaa aaggatttta agaaaaactt ctcttggccg     3900

ggcgcagtgg ctcacgcctg caatcccagc actttgggag gccgaggcgg gcggatcaca     3960

aggtcaggag atcgagacca cggtgaaacc ccgtctctac taaaaaatac aaaaaaaaat     4020

tagccgggtg cggtggcagg cgcctgtagt cccagctact cgggaggctg aggcaggaga     4080

atggtgtgaa cccgggaggc ggagcttgca gtgagccgag agcgcgccac tgcactccag     4140

cctgggtgac agagcgagac tccgtctcaa aaaaaaaaaa aaaagaaaaa cttctcttta     4200

ggctgggtgc ggttcctcat gcctataatc ccagcattta gggaggctga ggtgagtgga     4260

ttgcaggagc tcaggagttc gagaccagcc tgggcaaggt ggcaaaaccc cgtctctact     4320

aaaaaaaatt agctgggctt ggtggcaggc gcctgtaatc ccaggtactc gggagactga     4380

ggcaggagaa ttgcttgaac ctggaaggtg gaggttgcag tgagttgaga tcacaccaat     4440

gcactccagc cagggtgaga gtgagagact gtctcaaaaa aaaaaaaaac aaaagaaaaa     4500

cttctctcta gctctgtgac gggcagttca gataatacct tcaccagatt tacctgtttt     4560

cagctgaaga atgtgagatg aagccttgaa accctaaaag tgatatggta actagggcag     4620

gtctttctgt acataaaagt gacttaataa acagtgaatt tcatacaggt aaaccctatt     4680

ataccctcag ttctaaccat tggcctatct cttgcgtttt gttctaatgt agaattagat     4740

tgctacttga ctagttcagg aactctgttt agatctgata agtcataatc aaatcttgcc     4800

aggcgtggtg gtttatgcct gttatcccag cactttggga ggccaaggca ggtggaccac     4860

gtgaagtcag gagttcaaga caagcatggc caacatggcg aaaccctgta tctactaaaa     4920

atacaaaaat tagccgggca tggtggtggg tgcgtgtaat cccagctagt tgggaggctg     4980

aggcaggaga atcacttgaa cctgggaggc agaggttgca gtgagccgag atttccactg     5040

cattccagcc tgggcgatag agtaactctg tctcaaaaaa acccactaga tcatctctag     5100

aacattgcta ctcccaagta tgatttgagg aacagcagcc tcagtatcac cagggaactt     5160

attagaaata gtctcagcct caccactatt cccacttaat tgtaatctga tattaacaag     5220

atttcccaat gtgggtcagg tgtggtggct catgcctgta atcccacact ttgggaggcc     5280

aaggtgggcg gatcacttga ggctgggagt ttgagaccag gctggccaac atggggaaaa     5340

cccatctcta caaaaaataa caaaaattag gtgtgtgtgg tgacgcatgc gtgtaatccc     5400

agctacttag gaggctgagg caggagaatc acttgaatct gggaggcaga ggttgtagtg     5460

agctgagatt gtgccactgc actccagtct gggcaacaga gtgacactgt ttaaaaaaaa     5520

aaaaattccc aatgtgggcc gggtgcagtg gctcatgcct gtaatcccag cactttggga     5580

ggctgaggtg ggtgtatcac gaggtcaaga gatcaaggcc atcctggcca acatggtgaa     5640

accccgtctc tactgaaaat acaactgggc gtggtggtgc acgcctgtag tcccagctac     5700

ttgggaggct gaggcagaag aattgcttga cctgggaggc ggagcttgca gtgagcccag     5760

atcgtgccac tgcactgcac cctggcgaca cagcaagact gtctcaaaaa aaaaaaaatt     5820

cccaatgtgt atcttaaagt ttgagaaatg ctgatctaaa agatactaat gaccaggtgt     5880

gtagaggaca ttttcttaag cccttaagta caaatttaag aggtaagtgc ttcagccatt     5940

agggttactg gcttgttcat ctttcccact gagtgtaaat atttagctta gggtttaaaa     6000

tttgttatgt agctttttgc acttgtccat gtttatacta ctgtattatt attatttttt     6060

tttgagatgg agtctcgctg tgtagccagg ctggagtgca gtggtgcaat cttggctcac     6120

tgcaacctcc gtctctcggg ttcaagcaat tctcctgcct cagcttcccg aatagctgag     6180

actacaagcg tgcaccacca tgcccagcta atttttgtat ttttagtaga gacaggtttt     6240

caccatgttg gccaggctgg tctctatcta gacctcgtga tccatccgcc tcggcctccc     6300

aaagtgctgg gattataggc atgagccacc acgcccagcc tatagtactg tattcttatt     6360

ctccactctt gtgtgtgaaa agtcagctct tttggctttt ctgttatggg gaaacttgaa     6420

ttacacaggg aacccaactg aagaaaatga actgaagtag gtggcgctgg gtgaagtggg     6480

cccagagaat ggtgtacaca tccctcccat acatataccc aaacttctat ttttttatgt     6540

gacggagttt ctctcatcgc cccggctgga atgcaatggc acgatctcgg ctcactgcaa     6600

cctccgcctc ccgggttcaa gcgattctcc tgcatcagcc tcctgagtag ctgggattat     6660

aggcatgcac catcacgcct ggctaatttt tgtattttta gtagagatgg ggtttcgcca     6720

cgttggccag gctggtcttg aactcttgat ctcaagtgat ccacccgccc tggcctccca     6780

aagtgctggg attacaggcc tgagccacca ggccagcccc aacttctact ttttatttta     6840

tttataaatt gggggggggg ttctatattt agtttgaaga ggtggggaag atttgaaaac     6900

cactagattt accaggaaat ttttttcttc aaaaatattt tctgctttta tgatacttga     6960

atatctaata aaagacaata tttagccagt cacggtggct gatgcttgta atcctaacac     7020

tttgggaggc tgaggtgggt ggactactgg agccctggag ttcaaaaccg gcctaagcca     7080

catggcaaaa cagtctttac aaaaaataca aagatggtgg cttatgcctg tagtcgtacc     7140

tactcaggag gctgaggttg ggaggatcac ctgaatctgg gagtttgggg ctgcaataag     7200

ccatgattgt gccgctgcac tccagcctgg gtgacagtct gagaccctgt ctcaaaaaaa     7260

aaaaaaaaaa aaaaaaaaaa aaagactaca ttcactgtat acgtggcctt ttccccctaa     7320

ctagctatgt agcttcttaa aggcaaagat tcttcatagt gctttgcaca tgataggtgc     7380

tgatactcat tggatgaatg tatatagtga agaattttag atctgattac cacaattggg     7440

atcataaaca tgtataaact ccttgggagt ctgccttata tactttttat ccccctaaat     7500

gttccattaa tgttgcagag aggctcacta gttcctggag atgtcttatt aagtactgaa     7560

atgtgatttt ccaaaatttt ctttacaata caggcaaaag ataagtaaat tgtggacaaa     7620

gctttcatct ctatcagcag ctatagagag gaagtaaaca gcttagcccc taatacagga     7680

ggaagttgtt caactacagg cttgttagta gcaagttaaa ccagttacat tttataaaac     7740

agcctgagtg gtagggaagc tatcacttta atactctaga ggcagaatgc cacataggac     7800

tttgggtcac atatttcttt tccagggtct cctcaaaatg cagtttctat ttacagttga     7860

ctttggcccc tatttaccca taaaatgtca aaatcaagta gtatgaacat ggaaacagga     7920

gcagggacta aggtttggtc aagtggccct cattgttcca agagtaattt aggctatgta     7980

aacttgaaaa atatgggacc agattacctt ttgtctctaa attctactct tctttaagta     8040

gctggcactg tatctctgcc agggcacaga agtgggctcc ttactattct gaccactagc     8100

aagtggccaa ctcttcaaat acagggtagc tacctatttc acgtgaaagg cctcagtatt     8160

ctgctcactt gaactacgga aaataggcca caatacttgg ttacaatact ggaactctga     8220

acctatgtgg aggagagaaa aacaatggtg aacgagatac cagctgggct ctttccacat     8280

tcagggctca gcagtgttgg ggtttcactt gtctctaatc ctgaagaggt atctagccct     8340

ggaaggaagc tgagcctgta gctaacgcat aagcacagtg tattcaataa aacattttta     8400

ttctgtacaa ta                                                         8412


<210>  310
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Thr Gly Gln Asp Arg Val Val Ala Leu Val Asp Met Asp Cys 
1               5                   10                  15      


Phe Phe Val Gln Val Glu Gln Arg Gln Asn Pro His Leu Arg Asn Lys 
            20                  25                  30          


Pro Cys Ala Val Val Gln Tyr Lys Ser Trp Lys Gly Gly Gly Ile Ile 
        35                  40                  45              


Ala Val Ser Tyr Glu Ala Arg Ala Phe Gly Val Thr Arg Ser Met Trp 
    50                  55                  60                  


Ala Asp Asp Ala Lys Lys Leu Cys Pro Asp Leu Leu Leu Ala Gln Val 
65                  70                  75                  80  


Arg Glu Ser Arg Gly Lys Ala Asn Leu Thr Lys Tyr Arg Glu Ala Ser 
                85                  90                  95      


Val Glu Val Met Glu Ile Met Ser Arg Phe Ala Val Ile Glu Arg Ala 
            100                 105                 110         


Ser Ile Asp Glu Ala Tyr Val Asp Leu Thr Ser Ala Val Gln Glu Arg 
        115                 120                 125             


Leu Gln Lys Leu Gln Gly Gln Pro Ile Ser Ala Asp Leu Leu Pro Ser 
    130                 135                 140                 


Thr Tyr Ile Glu Gly Leu Pro Gln Gly Pro Thr Thr Ala Glu Glu Thr 
145                 150                 155                 160 


Val Gln Lys Glu Gly Met Arg Lys Gln Gly Leu Phe Gln Trp Leu Asp 
                165                 170                 175     


Ser Leu Gln Ile Asp Asn Leu Thr Ser Pro Asp Leu Gln Leu Thr Val 
            180                 185                 190         


Gly Ala Val Ile Val Glu Glu Met Arg Ala Ala Ile Glu Arg Glu Thr 
        195                 200                 205             


Gly Phe Gln Cys Ser Ala Gly Ile Ser His Asn Lys Val Leu Ala Lys 
    210                 215                 220                 


Leu Ala Cys Gly Leu Asn Lys Pro Asn Arg Gln Thr Leu Val Ser His 
225                 230                 235                 240 


Gly Ser Val Pro Gln Leu Phe Ser Gln Met Pro Ile Arg Lys Ile Arg 
                245                 250                 255     


Ser Leu Gly Gly Lys Leu Gly Ala Ser Val Ile Glu Ile Leu Gly Ile 
            260                 265                 270         


Glu Tyr Met Gly Glu Leu Thr Gln Phe Thr Glu Ser Gln Leu Gln Ser 
        275                 280                 285             


His Phe Gly Glu Lys Asn Gly Ser Trp Leu Tyr Ala Met Cys Arg Gly 
    290                 295                 300                 


Ile Glu His Asp Pro Val Lys Pro Arg Gln Leu Pro Lys Thr Ile Gly 
305                 310                 315                 320 


Cys Ser Lys Asn Phe Pro Gly Lys Thr Ala Leu Ala Thr Arg Glu Gln 
                325                 330                 335     


Val Gln Trp Trp Leu Leu Gln Leu Ala Gln Glu Leu Glu Glu Arg Leu 
            340                 345                 350         


Thr Lys Asp Arg Asn Asp Asn Asp Arg Val Ala Thr Gln Leu Val Val 
        355                 360                 365             


Ser Ile Arg Val Gln Gly Asp Lys Arg Leu Ser Ser Leu Arg Arg Cys 
    370                 375                 380                 


Cys Ala Leu Thr Arg Tyr Asp Ala His Lys Met Ser His Asp Ala Phe 
385                 390                 395                 400 


Thr Val Ile Lys Asn Cys Asn Thr Ser Gly Ile Gln Thr Glu Trp Ser 
                405                 410                 415     


Pro Pro Leu Thr Met Leu Phe Leu Cys Ala Thr Lys Phe Ser Ala Ser 
            420                 425                 430         


Ala Pro Ser Ser Ser Thr Asp Ile Thr Ser Phe Leu Ser Ser Asp Pro 
        435                 440                 445             


Ser Ser Leu Pro Lys Val Pro Val Thr Ser Ser Glu Ala Lys Thr Gln 
    450                 455                 460                 


Gly Ser Gly Pro Ala Val Thr Ala Thr Lys Lys Ala Thr Thr Ser Leu 
465                 470                 475                 480 


Glu Ser Phe Phe Gln Lys Ala Ala Glu Arg Gln Lys Val Lys Glu Ala 
                485                 490                 495     


Ser Leu Ser Ser Leu Thr Ala Pro Thr Gln Ala Pro Met Ser Asn Ser 
            500                 505                 510         


Pro Ser Lys Pro Ser Leu Pro Phe Gln Thr Ser Gln Ser Thr Gly Thr 
        515                 520                 525             


Glu Pro Phe Phe Lys Gln Lys Ser Leu Leu Leu Lys Gln Lys Gln Leu 
    530                 535                 540                 


Asn Asn Ser Ser Val Ser Ser Pro Gln Gln Asn Pro Trp Ser Asn Cys 
545                 550                 555                 560 


Lys Ala Leu Pro Asn Ser Leu Pro Thr Glu Tyr Pro Gly Cys Val Pro 
                565                 570                 575     


Val Cys Glu Gly Val Ser Lys Leu Glu Glu Ser Ser Lys Ala Thr Pro 
            580                 585                 590         


Ala Glu Met Asp Leu Ala His Asn Ser Gln Ser Met His Ala Ser Ser 
        595                 600                 605             


Ala Ser Lys Ser Val Leu Glu Val Thr Gln Lys Ala Thr Pro Asn Pro 
    610                 615                 620                 


Ser Leu Leu Ala Ala Glu Asp Gln Val Pro Cys Glu Lys Cys Gly Ser 
625                 630                 635                 640 


Leu Val Pro Val Trp Asp Met Pro Glu His Met Asp Tyr His Phe Ala 
                645                 650                 655     


Leu Glu Leu Gln Lys Ser Phe Leu Gln Pro His Ser Ser Asn Pro Gln 
            660                 665                 670         


Val Val Ser Ala Val Ser His Gln Gly Lys Arg Asn Pro Lys Ser Pro 
        675                 680                 685             


Leu Ala Cys Thr Asn Lys Arg Pro Arg Pro Glu Gly Met Gln Thr Leu 
    690                 695                 700                 


Glu Ser Phe Phe Lys Pro Leu Thr His 
705                 710             


<210>  311
<211>  4540
<212>  DNA
<213>  Homo sapiens

<400>  311
attctggggt tcgtttagag gtttgaattt tctcggagaa agacaggccg gccacgagga       60

aaacagaaac aagccgcagc aacatctaag cccttgaaag gatcctgaga gaggggggaa      120

agggaaaaca gcagccacca gcccaaccac ttgtgtcttc tgccccttcc cacctatctt      180

gcccacccca ccagcccacg ctgcttggga cttgaaatct gtggccgaag gaccgtcact      240

acataacttc aaaaataatc aaccaccctc ccttcccaaa ccacccaaat tcactcatcc      300

agcgtttact tttttgaatc cactcagaac ttttttctgc gacccccctc cctaaatgga      360

gttgggtggg ggggaaatga atactgagtt ggcctttatt ttttaaaaga ctttttgatc      420

caatgaggcc ccctaaataa ttgagttttg ggtcctggtt ggttgtttta ttttttttcc      480

tccaaaattt taccccctcc cccctgagcc cgaggtgctg acgtcgcaaa aaaattggat      540

aaaaccacca tcatgggttc gggtcccata gaccccaaag aacttctcaa gggcctggac      600

agcttcctta accgagatgg ggaagtcaaa agtgtggatg ggatttccaa gatcttcagt      660

ttgatgaagg aagcacgaaa gatggtgagt cgatgcactt acttgaacat tctcctgcag      720

acccgttcac cagaaatatt ggtcaaattt attgacgttg gcggctacaa acttcttaac      780

aattggctga cgtattcaaa gacaaccaac aacattcccc tcctccagca aattctactg      840

accctgcagc atctaccgct cactgtagac catctcaagc agaacaacac agctaaactg      900

gtgaagcagc tgagcaagtc aagtgaggat gaagagctcc ggaaattggc ctcagtcctt      960

gtcagcgact ggatggctgt catccgctct cagagcagta cccagcctgc tgagaaagat     1020

aagaagaaac gtaaagatga aggaaaaagt cgaactaccc ttcctgagcg acctttgaca     1080

gaggtgaagg ctgagacccg ggctgaggag gccccagaga agaagaggga gaagcccaag     1140

tctcttcgca ccacagcacc cagtcatgcc aagttccgtt ccactggact agagctggag     1200

acaccatcct tggtgcctgt gaagaagaat gccagcacag tggtggtttc tgacaagtac     1260

aaccttaaac ccatccccct caaacgtcag agcaacgtag ctgctccagg agatgccact     1320

ccccctgcag agaagaaata caagccactc aacacaacac ctaatgccac caaagagatc     1380

aaagtgaaga tcatcccgcc acagcctatg gagggcctgg gctttctgga tgctcttaat     1440

tcagcccctg ttccaggcat caaaattaag aagaaaaaaa aagtactgtc acctacggct     1500

gccaagccaa gcccctttga agggaaaacg agcacagaac caagcacagc caaaccttct     1560

tccccagaac cagcaccacc ttctgaggca atggacgcag accgtccagg caccccggtt     1620

ccccctgttg aagtcccgga gctcatggat acagcctctt tggagccagg agctctggat     1680

gccaagccag tggagagtcc tggagatcct aaccaactga cccggaaagg caggaagagg     1740

aaaagtgtga catggcctga ggaaggcaaa ctgagagaat atttctattt tgaattggat     1800

gaaactgaac gagtaaatgt gaataagatc aaggactttg gtgaggcggc taagcgagag     1860

atactgtcag accgacatgc atttgagaca gcgcggcgtc tgagccatga taacatggag     1920

gagaaggtgc cctgggtgtg cccccggccc ctggttctgc cctcacctct tgtcacccct     1980

ggaagcaata gtcaggagcg atatatccag gctgagcggg agaagggaat ccttcaggag     2040

ctcttcctga acaaggagag tcctcatgag cctgatcctg agccctacga gcccataccc     2100

cctaaactca tccccctaga tgaggagtgt tccatggatg agactccgta tgttgagact     2160

ctggaacctg gggggtcagg tggctcacct gatggggcag gaggctccaa gttgcctcca     2220

gttctggcca atcttatggg aagcatgggt gctggaaagg gcccccaagg ccctggagga     2280

ggaggcatta atgtccaaga gatcctcacc tccatcatgg gtagcccaaa cagtcatcct     2340

tcagaggaac tactgaaaca accagactat tcggacaaga tcaagcagat gctggtgcca     2400

catggactcc taggccctgg cccaatagcc aatggtttcc caccaggggg tcctgggggc     2460

cccaagggca tgcagcactt tccccctgga cctgggggac ctatgccagg tccccatgga     2520

ggccctggtg ggccagtggg tccacgtctt ctgggtcctc caccccctcc ccggggaggt     2580

gatcccttct gggatggccc gggcgaccct atgcggggtg gcccaatgcg ggggggtcca     2640

ggaccaggtc ctggaccata ccatagaggc cgaggtggcc gaggaggaaa cgaacctcct     2700

cctcctcctc ctccattccg aggcgccaga ggaggtcgct ctggaggagg acccccaaat     2760

ggacgagggg gccctggtgg gggcatggtt ggaggtggtg ggcatcgtcc tcacgaaggc     2820

cctggtgggg gcatgggcaa cagcagtgga catcgtcccc acgaaggccc tggcggtggc     2880

atgggaagtg ggcatcgccc ccatgaaggc cctggtggta gcatgggtgg gggtggagga     2940

catcgtcccc acgaaggccc tggcggtggc atcagtggtg gcagtggcca tcgtccccat     3000

gaaggccctg gcggaggaat gggtgccggt ggtggacatc gcccccacga aggccctggc     3060

ggaagcatgg gtggaagtgg tggacatcgt ccccatgaag gccctggaca cggggggccc     3120

catggccacc ggcctcatga tgtccctggt caccgaggcc atgaccatcg agggccgcca     3180

cctcatgagc accgtggcca tgatggtcct ggccacgggg gagggggcca ccgagggcac     3240

gatggaggcc acagccatgg aggagacatg tcaaaccgcc ctgtctgccg acatttcatg     3300

atgaagggca actgccgcta tgagaacaac tgtgccttct accacccggg tgtcaatggg     3360

ccccccctgc cctagggacc atttgcctgc cctgttcaca caacccctgt ggactgcagc     3420

ctcgctcttt ccaccctgtt atggcttctg tgaggcccat tttccctttt ccccagctga     3480

tgaggagccg gccccctcag ttcccacttg cttgggttcc tgggggtttt ctgatcactg     3540

gtgcgcattg atgtacatat tttcctccag tctggggagg agagagactg gaaacgttcc     3600

tggactgctg aagaggagac ccagttggct tcactttttg agaagattcg ccctgtaccc     3660

caaacccctt tccagtatta cccttaatgc ttgagaacct aaagctggtt atcctggcga     3720

acacccctac ccttctattg cgggtcccca catgcacaca gaactctgac acaggatcag     3780

ctgcacttaa gaaatcatcc cagctaagtt cattattcct catggggtgg ggagatgctg     3840

aaaggggtat tgtatatccc actgcactga gagggctcaa tcagctggat ttgagttctg     3900

gaacacacat catccccacc cctcccccag cgtgggctca ccattcttag tcctttctca     3960

agtgggacct tcaactttct gtgaacaccc agtctgcgtc ctgggtctgc taggttcgat     4020

gatggcgaac tcgtatctgc atccggtgca agttttagct ggcagaggtg agaccggtgg     4080

tgctggtctg cctttgccaa ctatagccag tctggagact tgataaaata cttcagtgag     4140

accagcttct catcaacttg ggcccggcgt gctgggcctg aaagtcacac tacatgcact     4200

gcctttggga gtcagctcac tccctgctcc cacctggaac cttgccagcg tgaaggaggc     4260

ttccaggtac ttcaccctgt caaccacctc tgaatcccca ccaggcgcct tcctgggtgg     4320

attcaacaag atgattttgc cctttcccag ttctctcctt cactttggca tcagttgttt     4380

tctatgaaaa cagtggattg gttgggtttt gtgcagggtc ttgggttaga gccaaaatgg     4440

atttgaggat gagtattttt ttttttggtt ttgtatattt tgtacattaa taataaacag     4500

tggaaagaga agcagcttaa aaaaaaaaaa aaaaaaaaaa                           4540


<210>  312
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 
1               5                   10                  15      


Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 
            20                  25                  30          


Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 
        35                  40                  45              


Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 
    50                  55                  60                  


Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 
65                  70                  75                  80  


Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 
                85                  90                  95      


Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 
            100                 105                 110         


Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 
        115                 120                 125             


Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 
    130                 135                 140                 


Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 
145                 150                 155                 160 


Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 
                165                 170                 175     


Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 
            180                 185                 190         


Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 
        195                 200                 205             


Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 
    210                 215                 220                 


Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 
225                 230                 235                 240 


Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 
                245                 250                 255     


Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 
            260                 265                 270         


Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 
        275                 280                 285             


Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 
    290                 295                 300                 


Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 
305                 310                 315                 320 


Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 
                325                 330                 335     


Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 
            340                 345                 350         


Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 
        355                 360                 365             


Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 
    370                 375                 380                 


Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 
385                 390                 395                 400 


Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 
                405                 410                 415     


Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 
            420                 425                 430         


Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 
    450                 455                 460                 


Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 
465                 470                 475                 480 


Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 
                485                 490                 495     


Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 
            500                 505                 510         


Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 
        515                 520                 525             


Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 
545                 550                 555                 560 


Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 
                565                 570                 575     


Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 
            580                 585                 590         


Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 
        595                 600                 605             


Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 
    610                 615                 620                 


Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 
625                 630                 635                 640 


Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 
                645                 650                 655     


Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 
            660                 665                 670         


Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 
        675                 680                 685             


Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 
    690                 695                 700                 


Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 
                725                 730                 735     


Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 
            740                 745                 750         


Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 
        755                 760                 765             


Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 
    770                 775                 780                 


Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 
785                 790                 795                 800 


Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 
                805                 810                 815     


Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 
            820                 825                 830         


Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 
        835                 840                 845             


Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 
    850                 855                 860                 


Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 
865                 870                 875                 880 


Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 
                885                 890                 895     


Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 
            900                 905                 910         


Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 
        915                 920                 925             


Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 
    930                 935                 940 


<210>  313
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  313
tcgctttgtg attcttgatc cggaacttgt cacccaggaa ccccggaaga ggtagctcac       60

gcgatagaaa cgtgttcgct gcccagaaga agggaaggcg cgagtgagga aaggaggtac      120

tgtagatgcc ctccaaatcc ttggttatgg aatatttggc tcatcccagt acactcggct      180

tggctgttgg agttgcttgt ggcatgtgcc tgggctggag ccttcgagta tgctttggga      240

tgctccccaa aagcaagacg agcaagacac acacagatac tgaaagtgaa gcaagcatct      300

tgggagacag cggggagtac aagatgattc ttgtggttcg aaatgactta aagatgggaa      360

aagggaaagt ggctgcccag tgctctcatg ctgctgtttc agcctacaag cagattcaaa      420

gaagaaatcc tgaaatgctc aaacaatggg aatactgtgg ccagcccaag gtggtggtca      480

aagctcctga tgaagaaacc ctgattgcat tattggccca tgcaaaaatg ctgggactga      540

ctgtaagttt aattcaagat gctggacgta ctcagattgc accaggctct caaactgtcc      600

tagggattgg gccaggacca gcagacctaa ttgacaaagt cactggtcac ctaaaacttt      660

actaggtgga ctttgatatg acaacaaccc ctccatcaca agtgtttgaa gcctgtcaga      720

ttctaacaac aaaagctgaa tttcttcacc caacttaaat gttcttgaga tgaaaataaa      780

acctattccc atgttctaaa aaaa                                             804


<210>  314
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Pro Ser Lys Ser Leu Val Met Glu Tyr Leu Ala His Pro Ser Thr 
1               5                   10                  15      


Leu Gly Leu Ala Val Gly Val Ala Cys Gly Met Cys Leu Gly Trp Ser 
            20                  25                  30          


Leu Arg Val Cys Phe Gly Met Leu Pro Lys Ser Lys Thr Ser Lys Thr 
        35                  40                  45              


His Thr Asp Thr Glu Ser Glu Ala Ser Ile Leu Gly Asp Ser Gly Glu 
    50                  55                  60                  


Tyr Lys Met Ile Leu Val Val Arg Asn Asp Leu Lys Met Gly Lys Gly 
65                  70                  75                  80  


Lys Val Ala Ala Gln Cys Ser His Ala Ala Val Ser Ala Tyr Lys Gln 
                85                  90                  95      


Ile Gln Arg Arg Asn Pro Glu Met Leu Lys Gln Trp Glu Tyr Cys Gly 
            100                 105                 110         


Gln Pro Lys Val Val Val Lys Ala Pro Asp Glu Glu Thr Leu Ile Ala 
        115                 120                 125             


Leu Leu Ala His Ala Lys Met Leu Gly Leu Thr Val Ser Leu Ile Gln 
    130                 135                 140                 


Asp Ala Gly Arg Thr Gln Ile Ala Pro Gly Ser Gln Thr Val Leu Gly 
145                 150                 155                 160 


Ile Gly Pro Gly Pro Ala Asp Leu Ile Asp Lys Val Thr Gly His Leu 
                165                 170                 175     


Lys Leu Tyr 
            


<210>  315
<211>  3788
<212>  DNA
<213>  Homo sapiens

<400>  315
gcgcgggcgc gcgcggcggc ggcgcgttcc gttccgggcc gaggctcgcg gcggaaaagt       60

tgcggggcat agacgagcgg ccccgggacg ggcagctagc gcgaccctga gccggcgccc      120

gtggtccggc catggacgac ctcgacgccc tgctggcgga cttggagtct accacctccc      180

acatctccaa acggcctgtg ttcttgtcgg aggagacccc ctactcatac ccaactggaa      240

accacacata ccaggagatt gccgtgccac cccccgtccc cccacccccg tccagcgagg      300

ccctcaatgg cacaatcctt gaccccttag accagtggca gcccagcagc tcccgattca      360

tccaccagca gcctcagtcc tcatcacctg tgtacggctc cagtgccaaa acttccagtg      420

tctccaaccc tcaggacagt gttggctctc cgtgctcccg agtgggtgag gaggagcacg      480

tctacagctt ccccaacaag cagaaatcag ctgagccttc acccaccgta atgagcacgt      540

ccctgggcag caacctttct gaactcgacc gcctgctgct ggaactgaac gctgtacagc      600

ataacccgcc aggcttccct gcagatgagg ccaactcaag ccccccgctt cctggggccc      660

tgagccccct ctatggtgtc ccagagacta acagcccctt gggaggcaaa gctgggcccc      720

tgacgaaaga gaagcctaag cggaatgggg gccggggcct ggaggacgtg cggcccagtg      780

tggagagtct cttggatgaa ctggagagct ccgtgcccag ccccgtccct gccatcactg      840

tgaaccaggg cgagatgagc agcccgcagc gcgtcacctc cacccaacag cagacacgca      900

tctcggcctc ctctgccacc agggagctgg acgagctgat ggcttcgctg tcggatttca      960

agatccaggg cctggagcaa agagcggatg gggagcggtg ctgggcggcc ggctggcctc     1020

gggacggcgg gcggagcagc cccggagggc aggacgaggg agggttcatg gcccagggga     1080

agacagggag cagctcaccc cctggggggc ccccgaagcc cgggagccag ctggacagca     1140

tgctggggag cctgcagtct gacctgaaca agctgggggt cgccacagtc gccaaaggag     1200

tctgcggggc ctgcaagaag cccatcgccg ggcaggttgt gaccgccatg gggaagacgt     1260

ggcaccccga gcacttcgtc tgcacccact gccaggagga gatcggatcc cggaacttct     1320

tcgagcggga tggacagccc tactgtgaaa aggactacca caacctcttc tccccgcgct     1380

gctactactg caacggcccc atcctggata aagtggtgac agcccttgac cggacgtggc     1440

accctgaaca cttcttctgt gcacagtgtg gagccttctt tggtcccgaa gggttccacg     1500

agaaggacgg caaggcctac tgtcgcaagg actacttcga catgttcgca cccaagtgtg     1560

gcggctgcgc ccgggccatc ctggagaact atatctcagc cctcaacacg ctgtggcatc     1620

ctgagtgctt tgtgtgccgg gaatgcttca cgccattcgt gaacggcagc ttcttcgagc     1680

acgacgggca gccctactgt gaggtgcact accacgagcg gcgcggctcg ctgtgttctg     1740

gctgccagaa gcccatcacc ggccgctgca tcaccgccat ggccaagaag ttccaccccg     1800

agcacttcgt ctgtgccttc tgcctcaagc agctcaacaa gggcaccttc aaggagcaga     1860

acgacaagcc ttactgtcag aactgcttcc tcaagctctt ctgctaggtg ccctgcccct     1920

gtctctgccc cccttcccca gccagcatcc ccaactgcga ctgtgaccta gagacttcac     1980

ccgggggtga aggggtaaac ccgactgaaa ctggaaccct tgtcctccgc tggtgcggga     2040

tggacagagg gccgtgaggg gtccccctgc ttgtcttcac ccctgccaga gcctctgggc     2100

cccctcctcc ctcctgtagc tctccctagg ctgcccactc tccatcctcc ccaggggtag     2160

aggctggggg ctccacccca gcccatgtac gtccccacga actggcctgg ccagcacccc     2220

acactggagc catctcttcc tcatatttca gcagtgcagc cggggggcag ggaagggcag     2280

gcagggtctg ttggggtctc tttttatcct tattcctccc ccgacctaat tgtctttgtt     2340

ctgtgattat tgggggacac ccggctccct ccagacaatg ccagcataaa tccatccatc     2400

caaaggcaga gaaccaaagg ggccatggaa ggttctctgt gctcctccta cccttccagt     2460

gccctaggcc tggcgactgc ccctgccttt tagacccgcc ctcccctttt atacctgctc     2520

ttgttctact gagaaaagcc tctccagcaa taatgttttc tagtcacttc ctccgtctcc     2580

gggacggcgt gcctggacac tgtaccgact ttgatagatt tctacactga ggtttgaatt     2640

catatcgcct gagttgcttt tacttctcta tacaaaatga ttttgaagag attttaaaga     2700

cgttcccttt tgtattctct tcctcatcca ccgccactgg gcctgtcact gatggtggct     2760

ctggtgtgaa gtttgctttg tactgagggt tggggtgggg aagcaatttg tattttattg     2820

tttcttagca caagcaggtg aactgggagc agctctgtga ctccccctct ttcacttcat     2880

agctcaccag gactgtttta taaactgctg tatttggaaa ccccttcttt acttcccagg     2940

ccagcaagct cttcactgaa actggttgaa gggtgttgca cccttttggg cctagaattc     3000

tgaactttat ctgttctgtt tctgtgggag gagaagggga agtatgtttt ggggggctgc     3060

ttcctgtctg agtaagccct caggagcctc tgctcccctg tgaacccact gaaccttctg     3120

agcccccact gcttctatgg ggctctctct tctgccttct caggaaagct ggtgtctgat     3180

tttggccatc aggactctga cgtctctttg gtcttgttga tttcctctgg gcatatccct     3240

tccccagatc tgctcctccc ctttcacagg tgggatcggc actcaggggg tctggaaaga     3300

aggtcataag ggagcatgat aggatttggg gcagagggac aggctcctct ggggaaaccc     3360

cccagagctc tttaccaagg atgaaagagg agccaggcct tgggctcctg atgaggagaa     3420

aggggcccca ccggggtcta atggtgacag tccaaaccac tccactggcc tcctggcaga     3480

agccgagtgt gctggggtct ccgaagaggg tccctccttt ttgggggaag gtcagcccag     3540

cccctccaaa ggtctgatgt ctccactttc acccgcaggc cttaccgctc tgtttatagt     3600

gacccaccct agatcttccc caagagggac tggggtttct ggggtccatt ctctgagtca     3660

gtggttattt gaaaatttga ttttgatttt attttttctc tgtaaacttc caagctggct     3720

tttcccattt caattcctgt gatttatgcc aataaagttt gcccatgatt ttcaaaaaaa     3780

aaaaaaaa                                                              3788


<210>  316
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Asp Asp Leu Asp Ala Leu Leu Ala Asp Leu Glu Ser Thr Thr Ser 
1               5                   10                  15      


His Ile Ser Lys Arg Pro Val Phe Leu Ser Glu Glu Thr Pro Tyr Ser 
            20                  25                  30          


Tyr Pro Thr Gly Asn His Thr Tyr Gln Glu Ile Ala Val Pro Pro Pro 
        35                  40                  45              


Val Pro Pro Pro Pro Ser Ser Glu Ala Leu Asn Gly Thr Ile Leu Asp 
    50                  55                  60                  


Pro Leu Asp Gln Trp Gln Pro Ser Ser Ser Arg Phe Ile His Gln Gln 
65                  70                  75                  80  


Pro Gln Ser Ser Ser Pro Val Tyr Gly Ser Ser Ala Lys Thr Ser Ser 
                85                  90                  95      


Val Ser Asn Pro Gln Asp Ser Val Gly Ser Pro Cys Ser Arg Val Gly 
            100                 105                 110         


Glu Glu Glu His Val Tyr Ser Phe Pro Asn Lys Gln Lys Ser Ala Glu 
        115                 120                 125             


Pro Ser Pro Thr Val Met Ser Thr Ser Leu Gly Ser Asn Leu Ser Glu 
    130                 135                 140                 


Leu Asp Arg Leu Leu Leu Glu Leu Asn Ala Val Gln His Asn Pro Pro 
145                 150                 155                 160 


Gly Phe Pro Ala Asp Glu Ala Asn Ser Ser Pro Pro Leu Pro Gly Ala 
                165                 170                 175     


Leu Ser Pro Leu Tyr Gly Val Pro Glu Thr Asn Ser Pro Leu Gly Gly 
            180                 185                 190         


Lys Ala Gly Pro Leu Thr Lys Glu Lys Pro Lys Arg Asn Gly Gly Arg 
        195                 200                 205             


Gly Leu Glu Asp Val Arg Pro Ser Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Glu Ser Ser Val Pro Ser Pro Val Pro Ala Ile Thr Val Asn Gln Gly 
225                 230                 235                 240 


Glu Met Ser Ser Pro Gln Arg Val Thr Ser Thr Gln Gln Gln Thr Arg 
                245                 250                 255     


Ile Ser Ala Ser Ser Ala Thr Arg Glu Leu Asp Glu Leu Met Ala Ser 
            260                 265                 270         


Leu Ser Asp Phe Lys Ile Gln Gly Leu Glu Gln Arg Ala Asp Gly Glu 
        275                 280                 285             


Arg Cys Trp Ala Ala Gly Trp Pro Arg Asp Gly Gly Arg Ser Ser Pro 
    290                 295                 300                 


Gly Gly Gln Asp Glu Gly Gly Phe Met Ala Gln Gly Lys Thr Gly Ser 
305                 310                 315                 320 


Ser Ser Pro Pro Gly Gly Pro Pro Lys Pro Gly Ser Gln Leu Asp Ser 
                325                 330                 335     


Met Leu Gly Ser Leu Gln Ser Asp Leu Asn Lys Leu Gly Val Ala Thr 
            340                 345                 350         


Val Ala Lys Gly Val Cys Gly Ala Cys Lys Lys Pro Ile Ala Gly Gln 
        355                 360                 365             


Val Val Thr Ala Met Gly Lys Thr Trp His Pro Glu His Phe Val Cys 
    370                 375                 380                 


Thr His Cys Gln Glu Glu Ile Gly Ser Arg Asn Phe Phe Glu Arg Asp 
385                 390                 395                 400 


Gly Gln Pro Tyr Cys Glu Lys Asp Tyr His Asn Leu Phe Ser Pro Arg 
                405                 410                 415     


Cys Tyr Tyr Cys Asn Gly Pro Ile Leu Asp Lys Val Val Thr Ala Leu 
            420                 425                 430         


Asp Arg Thr Trp His Pro Glu His Phe Phe Cys Ala Gln Cys Gly Ala 
        435                 440                 445             


Phe Phe Gly Pro Glu Gly Phe His Glu Lys Asp Gly Lys Ala Tyr Cys 
    450                 455                 460                 


Arg Lys Asp Tyr Phe Asp Met Phe Ala Pro Lys Cys Gly Gly Cys Ala 
465                 470                 475                 480 


Arg Ala Ile Leu Glu Asn Tyr Ile Ser Ala Leu Asn Thr Leu Trp His 
                485                 490                 495     


Pro Glu Cys Phe Val Cys Arg Glu Cys Phe Thr Pro Phe Val Asn Gly 
            500                 505                 510         


Ser Phe Phe Glu His Asp Gly Gln Pro Tyr Cys Glu Val His Tyr His 
        515                 520                 525             


Glu Arg Arg Gly Ser Leu Cys Ser Gly Cys Gln Lys Pro Ile Thr Gly 
    530                 535                 540                 


Arg Cys Ile Thr Ala Met Ala Lys Lys Phe His Pro Glu His Phe Val 
545                 550                 555                 560 


Cys Ala Phe Cys Leu Lys Gln Leu Asn Lys Gly Thr Phe Lys Glu Gln 
                565                 570                 575     


Asn Asp Lys Pro Tyr Cys Gln Asn Cys Phe Leu Lys Leu Phe Cys 
            580                 585                 590     


<210>  317
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  317
gcgcgggcgc gcgcggcggc ggcgcgttcc gttccgggcc gaggctcgcg gcggaaaagt       60

tgcggggcat agacgagcgg ccccgggacg ggcagctagc gcgaccctga gccggcgccc      120

gtggtccggc catggacgac ctcgacgccc tgctggcgga cttggagtct accacctccc      180

acatctccaa acggcctgtg ttcttgtcgg aggagacccc ctactcatac ccaactggaa      240

accacacata ccaggagatt gccgtgccac cccccgtccc cccacccccg tccagcgagg      300

ccctcaatgg cacaatcctt gaccccttag accagtggca gcccagcagc tcccgattca      360

tccaccagca gcctcagtcc tcatcacctg tgtacggctc cagtgccaaa acttccagtg      420

tctccaaccc tcaggacagt gttggctctc cgtgctcccg agtgggtgag gaggagcacg      480

tctacagctt ccccaacaag cagaaatcag ctgagccttc acccaccgta atgagcacgt      540

ccctgggcag caacctttct gaactcgacc gcctgctgct ggaactgaac gctgtacagc      600

ataacccgcc aggcttccct gcagatgagg ccaactcaag ccccccgctt cctggggccc      660

tgagccccct ctatggtgtc ccagagacta acagcccctt gggaggcaaa gctgggcccc      720

tgacgaaaga gaagcctaag cggaatgggg gccggggcct ggaggacgtg cggcccagtg      780

tggagagtct cttggatgaa ctggagagct ccgtgcccag ccccgtccct gccatcactg      840

tgaaccaggg cgagatgagc agcccgcagc gcgtcacctc cacccaacag cagacacgca      900

tctcggcctc ctctgccacc agggagctgg acgagctgat ggcttcgctg tcggatttca      960

agttcatggc ccaggggaag acagggagca gctcaccccc tggggggccc ccgaagcccg     1020

ggagccagct ggacagcatg ctggggagcc tgcagtctga cctgaacaag ctgggggtcg     1080

ccacagtcgc caaaggagtc tgcggggcct gcaagaagcc catcgccggg caggttgtga     1140

ccgccatggg gaagacgtgg caccccgagc acttcgtctg cacccactgc caggaggaga     1200

tcggatcccg gaacttcttc gagcgggatg gacagcccta ctgtgaaaag gactaccaca     1260

acctcttctc cccgcgctgc tactactgca acggccccat cctggataaa gtggtgacag     1320

cccttgaccg gacgtggcac cctgaacact tcttctgtgc acagtgtgga gccttctttg     1380

gtcccgaagg gttccacgag aaggacggca aggcctactg tcgcaaggac tacttcgaca     1440

tgttcgcacc caagtgtggc ggctgcgccc gggccatcct ggagaactat atctcagccc     1500

tcaacacgct gtggcatcct gagtgctttg tgtgccggga atgcttcacg ccattcgtga     1560

acggcagctt cttcgagcac gacgggcagc cctactgtga ggtgcactac cacgagcggc     1620

gcggctcgct gtgttctggc tgccagaagc ccatcaccgg ccgctgcatc accgccatgg     1680

ccaagaagtt ccaccccgag cacttcgtct gtgccttctg cctcaagcag ctcaacaagg     1740

gcaccttcaa ggagcagaac gacaagcctt actgtcagaa ctgcttcctc aagctcttct     1800

gctaggtgcc ctgcccctgt ctctgccccc cttccccagc cagcatcccc aactgcgact     1860

gtgacctaga gacttcaccc gggggtgaag gggtaaaccc gactgaaact ggaacccttg     1920

tcctccgctg gtgcgggatg gacagagggc cgtgaggggt ccccctgctt gtcttcaccc     1980

ctgccagagc ctctgggccc cctcctccct cctgtagctc tccctaggct gcccactctc     2040

catcctcccc aggggtagag gctgggggct ccaccccagc ccatgtacgt ccccacgaac     2100

tggcctggcc agcaccccac actggagcca tctcttcctc atatttcagc agtgcagccg     2160

gggggcaggg aagggcaggc agggtctgtt ggggtctctt tttatcctta ttcctccccc     2220

gacctaattg tctttgttct gtgattattg ggggacaccc ggctccctcc agacaatgcc     2280

agcataaatc catccatcca aaggcagaga accaaagggg ccatggaagg ttctctgtgc     2340

tcctcctacc cttccagtgc cctaggcctg gcgactgccc ctgcctttta gacccgccct     2400

ccccttttat acctgctctt gttctactga gaaaagcctc tccagcaata atgttttcta     2460

gtcacttcct ccgtctccgg gacggcgtgc ctggacactg taccgacttt gatagatttc     2520

tacactgagg tttgaattca tatcgcctga gttgctttta cttctctata caaaatgatt     2580

ttgaagagat tttaaagacg ttcccttttg tattctcttc ctcatccacc gccactgggc     2640

ctgtcactga tggtggctct ggtgtgaagt ttgctttgta ctgagggttg gggtggggaa     2700

gcaatttgta ttttattgtt tcttagcaca agcaggtgaa ctgggagcag ctctgtgact     2760

ccccctcttt cacttcatag ctcaccagga ctgttttata aactgctgta tttggaaacc     2820

ccttctttac ttcccaggcc agcaagctct tcactgaaac tggttgaagg gtgttgcacc     2880

cttttgggcc tagaattctg aactttatct gttctgtttc tgtgggagga gaaggggaag     2940

tatgttttgg ggggctgctt cctgtctgag taagccctca ggagcctctg ctcccctgtg     3000

aacccactga accttctgag cccccactgc ttctatgggg ctctctcttc tgccttctca     3060

ggaaagctgg tgtctgattt tggccatcag gactctgacg tctctttggt cttgttgatt     3120

tcctctgggc atatcccttc cccagatctg ctcctcccct ttcacaggtg ggatcggcac     3180

tcagggggtc tggaaagaag gtcataaggg agcatgatag gatttggggc agagggacag     3240

gctcctctgg ggaaaccccc cagagctctt taccaaggat gaaagaggag ccaggccttg     3300

ggctcctgat gaggagaaag gggccccacc ggggtctaat ggtgacagtc caaaccactc     3360

cactggcctc ctggcagaag ccgagtgtgc tggggtctcc gaagagggtc cctccttttt     3420

gggggaaggt cagcccagcc cctccaaagg tctgatgtct ccactttcac ccgcaggcct     3480

taccgctctg tttatagtga cccaccctag atcttcccca agagggactg gggtttctgg     3540

ggtccattct ctgagtcagt ggttatttga aaatttgatt ttgattttat tttttctctg     3600

taaacttcca agctggcttt tcccatttca attcctgtga tttatgccaa taaagtttgc     3660

ccatgatttt caaaaaaaaa aaaaaaaaaa a                                    3691


<210>  318
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asp Asp Leu Asp Ala Leu Leu Ala Asp Leu Glu Ser Thr Thr Ser 
1               5                   10                  15      


His Ile Ser Lys Arg Pro Val Phe Leu Ser Glu Glu Thr Pro Tyr Ser 
            20                  25                  30          


Tyr Pro Thr Gly Asn His Thr Tyr Gln Glu Ile Ala Val Pro Pro Pro 
        35                  40                  45              


Val Pro Pro Pro Pro Ser Ser Glu Ala Leu Asn Gly Thr Ile Leu Asp 
    50                  55                  60                  


Pro Leu Asp Gln Trp Gln Pro Ser Ser Ser Arg Phe Ile His Gln Gln 
65                  70                  75                  80  


Pro Gln Ser Ser Ser Pro Val Tyr Gly Ser Ser Ala Lys Thr Ser Ser 
                85                  90                  95      


Val Ser Asn Pro Gln Asp Ser Val Gly Ser Pro Cys Ser Arg Val Gly 
            100                 105                 110         


Glu Glu Glu His Val Tyr Ser Phe Pro Asn Lys Gln Lys Ser Ala Glu 
        115                 120                 125             


Pro Ser Pro Thr Val Met Ser Thr Ser Leu Gly Ser Asn Leu Ser Glu 
    130                 135                 140                 


Leu Asp Arg Leu Leu Leu Glu Leu Asn Ala Val Gln His Asn Pro Pro 
145                 150                 155                 160 


Gly Phe Pro Ala Asp Glu Ala Asn Ser Ser Pro Pro Leu Pro Gly Ala 
                165                 170                 175     


Leu Ser Pro Leu Tyr Gly Val Pro Glu Thr Asn Ser Pro Leu Gly Gly 
            180                 185                 190         


Lys Ala Gly Pro Leu Thr Lys Glu Lys Pro Lys Arg Asn Gly Gly Arg 
        195                 200                 205             


Gly Leu Glu Asp Val Arg Pro Ser Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Glu Ser Ser Val Pro Ser Pro Val Pro Ala Ile Thr Val Asn Gln Gly 
225                 230                 235                 240 


Glu Met Ser Ser Pro Gln Arg Val Thr Ser Thr Gln Gln Gln Thr Arg 
                245                 250                 255     


Ile Ser Ala Ser Ser Ala Thr Arg Glu Leu Asp Glu Leu Met Ala Ser 
            260                 265                 270         


Leu Ser Asp Phe Lys Phe Met Ala Gln Gly Lys Thr Gly Ser Ser Ser 
        275                 280                 285             


Pro Pro Gly Gly Pro Pro Lys Pro Gly Ser Gln Leu Asp Ser Met Leu 
    290                 295                 300                 


Gly Ser Leu Gln Ser Asp Leu Asn Lys Leu Gly Val Ala Thr Val Ala 
305                 310                 315                 320 


Lys Gly Val Cys Gly Ala Cys Lys Lys Pro Ile Ala Gly Gln Val Val 
                325                 330                 335     


Thr Ala Met Gly Lys Thr Trp His Pro Glu His Phe Val Cys Thr His 
            340                 345                 350         


Cys Gln Glu Glu Ile Gly Ser Arg Asn Phe Phe Glu Arg Asp Gly Gln 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Tyr His Asn Leu Phe Ser Pro Arg Cys Tyr 
    370                 375                 380                 


Tyr Cys Asn Gly Pro Ile Leu Asp Lys Val Val Thr Ala Leu Asp Arg 
385                 390                 395                 400 


Thr Trp His Pro Glu His Phe Phe Cys Ala Gln Cys Gly Ala Phe Phe 
                405                 410                 415     


Gly Pro Glu Gly Phe His Glu Lys Asp Gly Lys Ala Tyr Cys Arg Lys 
            420                 425                 430         


Asp Tyr Phe Asp Met Phe Ala Pro Lys Cys Gly Gly Cys Ala Arg Ala 
        435                 440                 445             


Ile Leu Glu Asn Tyr Ile Ser Ala Leu Asn Thr Leu Trp His Pro Glu 
    450                 455                 460                 


Cys Phe Val Cys Arg Glu Cys Phe Thr Pro Phe Val Asn Gly Ser Phe 
465                 470                 475                 480 


Phe Glu His Asp Gly Gln Pro Tyr Cys Glu Val His Tyr His Glu Arg 
                485                 490                 495     


Arg Gly Ser Leu Cys Ser Gly Cys Gln Lys Pro Ile Thr Gly Arg Cys 
            500                 505                 510         


Ile Thr Ala Met Ala Lys Lys Phe His Pro Glu His Phe Val Cys Ala 
        515                 520                 525             


Phe Cys Leu Lys Gln Leu Asn Lys Gly Thr Phe Lys Glu Gln Asn Asp 
    530                 535                 540                 


Lys Pro Tyr Cys Gln Asn Cys Phe Leu Lys Leu Phe Cys 
545                 550                 555         


<210>  319
<211>  3834
<212>  DNA
<213>  Homo sapiens

<400>  319
gtgtactcct ggctcggctg gccggctaag gcagtttctc atcactgatg tgctctggga       60

cagctgagtg ggatgggctc ctctggggtg ggtgtggagg agtggtcgtg atgcctggaa      120

cactgcagtc actcctcaga gacacgactt ggcagccctc ctgagcctgc ctggtcacat      180

gctgcctgtc ttggaaggtc ctctgtccca agcagtggat gtgcagtttc ttcacccctg      240

cttagcttca tcaggcacaa tgcgtctttg agacgccctg ctggcggact tggagtctac      300

cacctcccac atctccaaac ggcctgtgtt cttgtcggag gagaccccct actcataccc      360

aactggaaac cacacatacc aggagattgc cgtgccaccc cccgtccccc cacccccgtc      420

cagcgaggcc ctcaatggca caatccttga ccccttagac cagtggcagc ccagcagctc      480

ccgattcatc caccagcagc ctcagtcctc atcacctgtg tacggctcca gtgccaaaac      540

ttccagtgtc tccaaccctc aggacagtgt tggctctccg tgctcccgag tgggtgagga      600

ggagcacgtc tacagcttcc ccaacaagca gaaatcagct gagccttcac ccaccgtaat      660

gagcacgtcc ctgggcagca acctttctga actcgaccgc ctgctgctgg aactgaacgc      720

tgtacagcat aacccgccag gcttccctgc agatgaggcc aactcaagcc ccccgcttcc      780

tggggccctg agccccctct atggtgtccc agagactaac agccccttgg gaggcaaagc      840

tgggcccctg acgaaagaga agcctaagcg gaatgggggc cggggcctgg aggacgtgcg      900

gcccagtgtg gagagtctct tggatgaact ggagagctcc gtgcccagcc ccgtccctgc      960

catcactgtg aaccagggcg agatgagcag cccgcagcgc gtcacctcca cccaacagca     1020

gacacgcatc tcggcctcct ctgccaccag ggagctggac gagctgatgg cttcgctgtc     1080

ggatttcaag ttcatggccc aggggaagac agggagcagc tcaccccctg gggggccccc     1140

gaagcccggg agccagctgg acagcatgct ggggagcctg cagtctgacc tgaacaagct     1200

gggggtcgcc acagtcgcca aaggagtctg cggggcctgc aagaagccca tcgccgggca     1260

ggttgtgacc gccatgggga agacgtggca ccccgagcac ttcgtctgca cccactgcca     1320

ggaggagatc ggatcccgga acttcttcga gcgggatgga cagccctact gtgaaaagga     1380

ctaccacaac ctcttctccc cgcgctgcta ctactgcaac ggccccatcc tggataaagt     1440

ggtgacagcc cttgaccgga cgtggcaccc tgaacacttc ttctgtgcac agtgtggagc     1500

cttctttggt cccgaagggt tccacgagaa ggacggcaag gcctactgtc gcaaggacta     1560

cttcgacatg ttcgcaccca agtgtggcgg ctgcgcccgg gccatcctgg agaactatat     1620

ctcagccctc aacacgctgt ggcatcctga gtgctttgtg tgccgggaat gcttcacgcc     1680

attcgtgaac ggcagcttct tcgagcacga cgggcagccc tactgtgagg tgcactacca     1740

cgagcggcgc ggctcgctgt gttctggctg ccagaagccc atcaccggcc gctgcatcac     1800

cgccatggcc aagaagttcc accccgagca cttcgtctgt gccttctgcc tcaagcagct     1860

caacaagggc accttcaagg agcagaacga caagccttac tgtcagaact gcttcctcaa     1920

gctcttctgc taggtgccct gcccctgtct ctgcccccct tccccagcca gcatccccaa     1980

ctgcgactgt gacctagaga cttcacccgg gggtgaaggg gtaaacccga ctgaaactgg     2040

aacccttgtc ctccgctggt gcgggatgga cagagggccg tgaggggtcc ccctgcttgt     2100

cttcacccct gccagagcct ctgggccccc tcctccctcc tgtagctctc cctaggctgc     2160

ccactctcca tcctccccag gggtagaggc tgggggctcc accccagccc atgtacgtcc     2220

ccacgaactg gcctggccag caccccacac tggagccatc tcttcctcat atttcagcag     2280

tgcagccggg gggcagggaa gggcaggcag ggtctgttgg ggtctctttt tatccttatt     2340

cctcccccga cctaattgtc tttgttctgt gattattggg ggacacccgg ctccctccag     2400

acaatgccag cataaatcca tccatccaaa ggcagagaac caaaggggcc atggaaggtt     2460

ctctgtgctc ctcctaccct tccagtgccc taggcctggc gactgcccct gccttttaga     2520

cccgccctcc ccttttatac ctgctcttgt tctactgaga aaagcctctc cagcaataat     2580

gttttctagt cacttcctcc gtctccggga cggcgtgcct ggacactgta ccgactttga     2640

tagatttcta cactgaggtt tgaattcata tcgcctgagt tgcttttact tctctataca     2700

aaatgatttt gaagagattt taaagacgtt cccttttgta ttctcttcct catccaccgc     2760

cactgggcct gtcactgatg gtggctctgg tgtgaagttt gctttgtact gagggttggg     2820

gtggggaagc aatttgtatt ttattgtttc ttagcacaag caggtgaact gggagcagct     2880

ctgtgactcc ccctctttca cttcatagct caccaggact gttttataaa ctgctgtatt     2940

tggaaacccc ttctttactt cccaggccag caagctcttc actgaaactg gttgaagggt     3000

gttgcaccct tttgggccta gaattctgaa ctttatctgt tctgtttctg tgggaggaga     3060

aggggaagta tgttttgggg ggctgcttcc tgtctgagta agccctcagg agcctctgct     3120

cccctgtgaa cccactgaac cttctgagcc cccactgctt ctatggggct ctctcttctg     3180

ccttctcagg aaagctggtg tctgattttg gccatcagga ctctgacgtc tctttggtct     3240

tgttgatttc ctctgggcat atcccttccc cagatctgct cctccccttt cacaggtggg     3300

atcggcactc agggggtctg gaaagaaggt cataagggag catgatagga tttggggcag     3360

agggacaggc tcctctgggg aaacccccca gagctcttta ccaaggatga aagaggagcc     3420

aggccttggg ctcctgatga ggagaaaggg gccccaccgg ggtctaatgg tgacagtcca     3480

aaccactcca ctggcctcct ggcagaagcc gagtgtgctg gggtctccga agagggtccc     3540

tcctttttgg gggaaggtca gcccagcccc tccaaaggtc tgatgtctcc actttcaccc     3600

gcaggcctta ccgctctgtt tatagtgacc caccctagat cttccccaag agggactggg     3660

gtttctgggg tccattctct gagtcagtgg ttatttgaaa atttgatttt gattttattt     3720

tttctctgta aacttccaag ctggcttttc ccatttcaat tcctgtgatt tatgccaata     3780

aagtttgccc atgattttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           3834


<210>  320
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Ser Thr Ser Leu Gly Ser Asn Leu Ser Glu Leu Asp Arg Leu Leu 
1               5                   10                  15      


Leu Glu Leu Asn Ala Val Gln His Asn Pro Pro Gly Phe Pro Ala Asp 
            20                  25                  30          


Glu Ala Asn Ser Ser Pro Pro Leu Pro Gly Ala Leu Ser Pro Leu Tyr 
        35                  40                  45              


Gly Val Pro Glu Thr Asn Ser Pro Leu Gly Gly Lys Ala Gly Pro Leu 
    50                  55                  60                  


Thr Lys Glu Lys Pro Lys Arg Asn Gly Gly Arg Gly Leu Glu Asp Val 
65                  70                  75                  80  


Arg Pro Ser Val Glu Ser Leu Leu Asp Glu Leu Glu Ser Ser Val Pro 
                85                  90                  95      


Ser Pro Val Pro Ala Ile Thr Val Asn Gln Gly Glu Met Ser Ser Pro 
            100                 105                 110         


Gln Arg Val Thr Ser Thr Gln Gln Gln Thr Arg Ile Ser Ala Ser Ser 
        115                 120                 125             


Ala Thr Arg Glu Leu Asp Glu Leu Met Ala Ser Leu Ser Asp Phe Lys 
    130                 135                 140                 


Phe Met Ala Gln Gly Lys Thr Gly Ser Ser Ser Pro Pro Gly Gly Pro 
145                 150                 155                 160 


Pro Lys Pro Gly Ser Gln Leu Asp Ser Met Leu Gly Ser Leu Gln Ser 
                165                 170                 175     


Asp Leu Asn Lys Leu Gly Val Ala Thr Val Ala Lys Gly Val Cys Gly 
            180                 185                 190         


Ala Cys Lys Lys Pro Ile Ala Gly Gln Val Val Thr Ala Met Gly Lys 
        195                 200                 205             


Thr Trp His Pro Glu His Phe Val Cys Thr His Cys Gln Glu Glu Ile 
    210                 215                 220                 


Gly Ser Arg Asn Phe Phe Glu Arg Asp Gly Gln Pro Tyr Cys Glu Lys 
225                 230                 235                 240 


Asp Tyr His Asn Leu Phe Ser Pro Arg Cys Tyr Tyr Cys Asn Gly Pro 
                245                 250                 255     


Ile Leu Asp Lys Val Val Thr Ala Leu Asp Arg Thr Trp His Pro Glu 
            260                 265                 270         


His Phe Phe Cys Ala Gln Cys Gly Ala Phe Phe Gly Pro Glu Gly Phe 
        275                 280                 285             


His Glu Lys Asp Gly Lys Ala Tyr Cys Arg Lys Asp Tyr Phe Asp Met 
    290                 295                 300                 


Phe Ala Pro Lys Cys Gly Gly Cys Ala Arg Ala Ile Leu Glu Asn Tyr 
305                 310                 315                 320 


Ile Ser Ala Leu Asn Thr Leu Trp His Pro Glu Cys Phe Val Cys Arg 
                325                 330                 335     


Glu Cys Phe Thr Pro Phe Val Asn Gly Ser Phe Phe Glu His Asp Gly 
            340                 345                 350         


Gln Pro Tyr Cys Glu Val His Tyr His Glu Arg Arg Gly Ser Leu Cys 
        355                 360                 365             


Ser Gly Cys Gln Lys Pro Ile Thr Gly Arg Cys Ile Thr Ala Met Ala 
    370                 375                 380                 


Lys Lys Phe His Pro Glu His Phe Val Cys Ala Phe Cys Leu Lys Gln 
385                 390                 395                 400 


Leu Asn Lys Gly Thr Phe Lys Glu Gln Asn Asp Lys Pro Tyr Cys Gln 
                405                 410                 415     


Asn Cys Phe Leu Lys Leu Phe Cys 
            420                 


<210>  321
<211>  2437
<212>  DNA
<213>  Homo sapiens

<400>  321
ctgcaatggc ggctctagac tccctgtcgc tcttcactag cctcggcctg agcgagcaga       60

aggcccgcga gacgctcaag aactcggctc tgagcgcgca gctgcgcgag gccgctactc      120

aggctcagca gaccctgggt tccaccattg acaaagctac cgggatcctg ttatatggct      180

tggcctcccg actcagggat acccggcgtc tctccttcct tgtaagctac atagccagta      240

agaagatcca cactgagccc cagctaagcg ctgcccttga gtatgtgcgg agtcacccct      300

tggaccccat cgacactgtg gacttcgagc gggaatgtgg cgtgggtgtc attgtgaccc      360

cagagcagat tgaggaggct gtggaggctg ctattaacag gcaccggccc cagctcctgg      420

tggaacgtta ccatttcaac atggggctgc tgatgggaga ggctcgggct gtgctgaagt      480

gggcagatgg caaaatgatc aagaatgaag tggacatgca ggtcctccac cttctgggcc      540

ccaagttgga ggctgatctg gagaagaagt tcaaggtggc aaaagctcgg ctagaagaaa      600

cagaccggag gacggcaaag gatgtggtgg agaatggcga gactgctgac cagaccctgt      660

ctctgatgga gcagctccgg ggggaggccc ttaagttcca caagcctggt gagaactaca      720

agaccccagg ctatgtggtc actccacaca ccatgaatct actaaagcag cacctggaga      780

ttactggtgg gcaggtacgt acccggttcc cgccagaacc caatggaatc ctgcatattg      840

gacatgccaa agccatcaat ttcaactttg gctatgccaa ggccaacaat ggcatctgtt      900

ttctgcgttt tgatgacacc aaccctgaga aggaggaagc aaagttcttc acggccatct      960

gtgacatggt agcctggcta ggctacacac cttacaaagt cacatatgcg tctgactatt     1020

ttgaccagct atatgcgtgg gctgtggagc tcatccgcag gggtctggct tatgtgtgcc     1080

accagcgagg agaggagctc aaaggccata atactctgcc ttcaccctgg agagaccgtc     1140

ccatggagga gtcactgctg ctctttgagg caatgcgcaa gggcaagttt tcagagggcg     1200

aggccacact acggatgaag ctggtgatgg aggatggcaa gatggaccct gtagcctatc     1260

gagtcaagta tacaccacac caccgcacag gggacaaatg gtgcatctat cccacctacg     1320

actacacaca ctgcctctgt gactccatcg agcacatcac tcactcactc tgcaccaagg     1380

aattccaggc ccgacgctct tcctacttct ggctttgcaa tgcactggac gtctattgcc     1440

ctgtgcagtg ggagtatggc cgcctcaacc tgcactatgc tgttgtctct aagaggaaga     1500

tcctccagct tgtagcaact ggtgctgtgc gggactggga tgacccacgg ctctttacac     1560

tcacggccct gcgacggcgg ggcttcccac ctgaggccat caacaacttc tgtgcccggg     1620

tgggagtgac tgtggcacaa accacaatgg agccacatct tctagaagcc tgtgtgcgtg     1680

atgtgctgaa tgacacagcc ccacgagcca tggctgtgct ggagtcacta cgggtcatca     1740

tcaccaactt tcctgctgcc aagtccttgg acatccaggt gcccaacttc ccagctgatg     1800

agaccaaagg cttccatcag gttccctttg cacccattgt cttcattgag aggactgact     1860

tcaaggagga gccagagcca ggatttaagc gcctggcttg gggccagcct gtgggcctga     1920

ggcatacagg ctacgtcatt gagctgcagc atgttgtcaa gggccccagt ggttgtgtag     1980

agagtctgga ggtgacctgc agacgggcag atgctggaga gaagccaaag gcctttattc     2040

actgggtgtc acagcctttg atgtgtgagg ttcgcctcta tgagcgacta ttccagcaca     2100

agaaccctga agatcctact gaggtgcctg gtggattttt aagtgacctg aacctggcat     2160

cactacacgt ggtggatgca gcattagtgg actgctctgt ggccctggca aaacccttcg     2220

acaagttcca gtttgagcgt cttggatatt tctccgtgga tccagacagc catcagggaa     2280

agcttgtctt taaccgaact gtcacactga aggaagaccc aggaaaggtg tgagctggaa     2340

gcactgaacc tacctcatcc tcctggaggg tgtggctacc ctcgccaccc caaattccat     2400

gtcaataaag aacagctaaa ttctcctaga aaaaaaa                              2437


<210>  322
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Ala Ala Leu Asp Ser Leu Ser Leu Phe Thr Ser Leu Gly Leu Ser 
1               5                   10                  15      


Glu Gln Lys Ala Arg Glu Thr Leu Lys Asn Ser Ala Leu Ser Ala Gln 
            20                  25                  30          


Leu Arg Glu Ala Ala Thr Gln Ala Gln Gln Thr Leu Gly Ser Thr Ile 
        35                  40                  45              


Asp Lys Ala Thr Gly Ile Leu Leu Tyr Gly Leu Ala Ser Arg Leu Arg 
    50                  55                  60                  


Asp Thr Arg Arg Leu Ser Phe Leu Val Ser Tyr Ile Ala Ser Lys Lys 
65                  70                  75                  80  


Ile His Thr Glu Pro Gln Leu Ser Ala Ala Leu Glu Tyr Val Arg Ser 
                85                  90                  95      


His Pro Leu Asp Pro Ile Asp Thr Val Asp Phe Glu Arg Glu Cys Gly 
            100                 105                 110         


Val Gly Val Ile Val Thr Pro Glu Gln Ile Glu Glu Ala Val Glu Ala 
        115                 120                 125             


Ala Ile Asn Arg His Arg Pro Gln Leu Leu Val Glu Arg Tyr His Phe 
    130                 135                 140                 


Asn Met Gly Leu Leu Met Gly Glu Ala Arg Ala Val Leu Lys Trp Ala 
145                 150                 155                 160 


Asp Gly Lys Met Ile Lys Asn Glu Val Asp Met Gln Val Leu His Leu 
                165                 170                 175     


Leu Gly Pro Lys Leu Glu Ala Asp Leu Glu Lys Lys Phe Lys Val Ala 
            180                 185                 190         


Lys Ala Arg Leu Glu Glu Thr Asp Arg Arg Thr Ala Lys Asp Val Val 
        195                 200                 205             


Glu Asn Gly Glu Thr Ala Asp Gln Thr Leu Ser Leu Met Glu Gln Leu 
    210                 215                 220                 


Arg Gly Glu Ala Leu Lys Phe His Lys Pro Gly Glu Asn Tyr Lys Thr 
225                 230                 235                 240 


Pro Gly Tyr Val Val Thr Pro His Thr Met Asn Leu Leu Lys Gln His 
                245                 250                 255     


Leu Glu Ile Thr Gly Gly Gln Val Arg Thr Arg Phe Pro Pro Glu Pro 
            260                 265                 270         


Asn Gly Ile Leu His Ile Gly His Ala Lys Ala Ile Asn Phe Asn Phe 
        275                 280                 285             


Gly Tyr Ala Lys Ala Asn Asn Gly Ile Cys Phe Leu Arg Phe Asp Asp 
    290                 295                 300                 


Thr Asn Pro Glu Lys Glu Glu Ala Lys Phe Phe Thr Ala Ile Cys Asp 
305                 310                 315                 320 


Met Val Ala Trp Leu Gly Tyr Thr Pro Tyr Lys Val Thr Tyr Ala Ser 
                325                 330                 335     


Asp Tyr Phe Asp Gln Leu Tyr Ala Trp Ala Val Glu Leu Ile Arg Arg 
            340                 345                 350         


Gly Leu Ala Tyr Val Cys His Gln Arg Gly Glu Glu Leu Lys Gly His 
        355                 360                 365             


Asn Thr Leu Pro Ser Pro Trp Arg Asp Arg Pro Met Glu Glu Ser Leu 
    370                 375                 380                 


Leu Leu Phe Glu Ala Met Arg Lys Gly Lys Phe Ser Glu Gly Glu Ala 
385                 390                 395                 400 


Thr Leu Arg Met Lys Leu Val Met Glu Asp Gly Lys Met Asp Pro Val 
                405                 410                 415     


Ala Tyr Arg Val Lys Tyr Thr Pro His His Arg Thr Gly Asp Lys Trp 
            420                 425                 430         


Cys Ile Tyr Pro Thr Tyr Asp Tyr Thr His Cys Leu Cys Asp Ser Ile 
        435                 440                 445             


Glu His Ile Thr His Ser Leu Cys Thr Lys Glu Phe Gln Ala Arg Arg 
    450                 455                 460                 


Ser Ser Tyr Phe Trp Leu Cys Asn Ala Leu Asp Val Tyr Cys Pro Val 
465                 470                 475                 480 


Gln Trp Glu Tyr Gly Arg Leu Asn Leu His Tyr Ala Val Val Ser Lys 
                485                 490                 495     


Arg Lys Ile Leu Gln Leu Val Ala Thr Gly Ala Val Arg Asp Trp Asp 
            500                 505                 510         


Asp Pro Arg Leu Phe Thr Leu Thr Ala Leu Arg Arg Arg Gly Phe Pro 
        515                 520                 525             


Pro Glu Ala Ile Asn Asn Phe Cys Ala Arg Val Gly Val Thr Val Ala 
    530                 535                 540                 


Gln Thr Thr Met Glu Pro His Leu Leu Glu Ala Cys Val Arg Asp Val 
545                 550                 555                 560 


Leu Asn Asp Thr Ala Pro Arg Ala Met Ala Val Leu Glu Ser Leu Arg 
                565                 570                 575     


Val Ile Ile Thr Asn Phe Pro Ala Ala Lys Ser Leu Asp Ile Gln Val 
            580                 585                 590         


Pro Asn Phe Pro Ala Asp Glu Thr Lys Gly Phe His Gln Val Pro Phe 
        595                 600                 605             


Ala Pro Ile Val Phe Ile Glu Arg Thr Asp Phe Lys Glu Glu Pro Glu 
    610                 615                 620                 


Pro Gly Phe Lys Arg Leu Ala Trp Gly Gln Pro Val Gly Leu Arg His 
625                 630                 635                 640 


Thr Gly Tyr Val Ile Glu Leu Gln His Val Val Lys Gly Pro Ser Gly 
                645                 650                 655     


Cys Val Glu Ser Leu Glu Val Thr Cys Arg Arg Ala Asp Ala Gly Glu 
            660                 665                 670         


Lys Pro Lys Ala Phe Ile His Trp Val Ser Gln Pro Leu Met Cys Glu 
        675                 680                 685             


Val Arg Leu Tyr Glu Arg Leu Phe Gln His Lys Asn Pro Glu Asp Pro 
    690                 695                 700                 


Thr Glu Val Pro Gly Gly Phe Leu Ser Asp Leu Asn Leu Ala Ser Leu 
705                 710                 715                 720 


His Val Val Asp Ala Ala Leu Val Asp Cys Ser Val Ala Leu Ala Lys 
                725                 730                 735     


Pro Phe Asp Lys Phe Gln Phe Glu Arg Leu Gly Tyr Phe Ser Val Asp 
            740                 745                 750         


Pro Asp Ser His Gln Gly Lys Leu Val Phe Asn Arg Thr Val Thr Leu 
        755                 760                 765             


Lys Glu Asp Pro Gly Lys Val 
    770                 775 


<210>  323
<211>  3883
<212>  DNA
<213>  Homo sapiens

<400>  323
aggcgttaac ccagggaagg cagtggcaag atggcgtccc tggatcgggt gaaggtactg       60

gtgttgggag actcaggtgt tgggaaatct tcgttagtcc atctcctatg ccaaaatcaa      120

gtgctgggaa atccatcatg gactgtgggc tgctcagtgg atgtcagagt tcatgattac      180

aaagaaggaa ccccagaaga gaagacctac tacatagaat tatgggatgt tggaggctct      240

gtgggcagtg ccagcagcgt gaaaagcaca agagcagtat tctacaactc cgtaaatggt      300

attattttcg tacacgactt aacaaataag aagtcctccc aaaacttgcg tcgttggtca      360

ttggaagctc tcaacaggga tttggtgcca actggagtct tggtgacaaa tggggattat      420

gatcaagaac agtttgctga taaccaaata ccactgttgg taatagggac taaactggac      480

cagattcatg aaacaaagcg ccatgaagtt ttaactagga ctgctttcct ggctgaggat      540

ttcaatccag aagaaattaa tttggactgc acaaatccac ggtacttagc tgcaggttct      600

tccaatgctg tcaagctcag taggtttttt gataaggtca tagagaagag atacttttta      660

agagaaggta atcagattcc aggctttcct gatcggaaaa gatttggggc aggaacatta      720

aagagccttc attatgactg aattacactc atcctttgga agagtgagca agcagtggca      780

gtttttcaca gctcatcttg ctgtgttcaa ttattaccat cacagccttt taacaaaatc      840

atcttaaaat gctacccttc agccttaccc tttaatggaa aaatgaaagg aagtgacaat      900

acgggaggtc caaactttgt ccctgttctc tgtgttcctt acctttctgt ccctgtgtat      960

agattatgta aaagccttgt gtaaatatga gatgttgtca aaatgatgca gtaaatgagc     1020

aatgacagtg tactgcagag aaaatttact cttgcctaga actggagggt ttttatgggt     1080

ctgtaatttt cccacactca ttgctgaaag cttaattaag tacttcaaaa acgtatctcc     1140

attgttttac cttcttgagg ggaacggtct tgttaaccag ccctgagttg tctaccccaa     1200

acaatctctg tcattttcaa agatgcaaaa tggtgttatt taattgtctc caccattgtc     1260

acacacagga atgcctaata atagcaaccc ttgtctccct cttctctcct ttgcaaatgg     1320

ctcagtgact ggaagaggcg gactaatagc cagagttaaa tataaataca aattaataat     1380

acatagagaa cagcaatacc agaaaaaaag aattctggta aaatgatgtg aaaaattgac     1440

agctccctca ctcttaaggt tgctgctata tacagtctag gttttctgtt tggaaatagg     1500

tagggtaaaa tctaagacct gcacaagggc agtgagagac atttacagcc tcctctctat     1560

ttgttttttt aaggaaaagt caactcctga aatgtccctt agctataatc agaaaactaa     1620

gaatattatt ctgtgtcaac aatgtattta tggagagaag taaaaataag ttccacagca     1680

acacatttac atgaattatg aactaggatt cttggatttc ataatcactc caaagctttt     1740

tggggatggt gtgtgtgtgt gtgtgtgtcc gtaattgttc atcattactt tttttaacct     1800

atctttttgc ttgcttaatc ttctctgccc cagttcttcc tgagtatatg aatttgattt     1860

ctaaaaacaa tttattcaac actctatcac ccgtattctc tctctggctc tgctgcaggt     1920

ctctgcactc ctgattttgc tccatacttt taaataacaa taataaatat acagttttca     1980

tttctcattt aaaaaatagg tggaaaacac caaattcact ttctgttcca ttttaattag     2040

gtttcagaag tatcttggaa atcaaggtat gctgcaagag gatattaaaa taagaatgtt     2100

agagagtcct tttagaaagg cagtcttggg aatttggaaa aggattttta aagcagcttt     2160

catcagctag actgttctcc agcctttctt tacttcctct ttgaaaggac atagccctgg     2220

tttctttttg acacaaagga aagctatgca aatcatgatc tgtatgtaga attggtcaca     2280

agtatgttgt tgcataggct gtacagttgg gaagtagaaa ccaaatgcta cccagagacc     2340

taacccaatt aagctctttg tatttctcct tcaagaaata aatcttcctt ccttctttct     2400

tcctctttct tttaatttta aaaaaattca tcctgatttt tttattttct atcttattta     2460

aaaaataaaa ataggccagg cgcggtggct cacaccttta atcccaacac tttgggaggc     2520

gggtcgatca cttgatatca ggagtttgag accagcctgg ccaacatagg gaaaccctgt     2580

ctctactaaa aatacaaaaa ttagccaggc ctggtggcac gcgcctgtaa tcccagctac     2640

ttgggaggct gaggcaggag aatcacttga acctgggagg tggaggttgc agtgagtcaa     2700

gatcgtgtca ctgcactcca gcctaggtga cagagtgaga ctccaactaa aagaaaataa     2760

ataaataaat atataaatat ataaataaat aataaaagta aactattgct gatgactcca     2820

gggtcaatct ggaaaaatta acagtattcc tcaactccat tactttctgc agccaagctt     2880

gattccttga attatagttt tctaagaaaa aatagttttt aataatctaa ggtaaatttg     2940

ttgcaattat tagcagcagc ataataaggc tttttgcgca aatgaatgtt attagctaga     3000

gttattcaaa aaagaatgaa gcacaatttt tgctaggact tcttgagaac tattcataaa     3060

aatgctttta gataataaac aagtataaat gtcaaaatat ttttttaaaa gtataattgg     3120

ccaggtgctg gctcacgcct ataatcccag cactctagga gactgaggca ggaggatcac     3180

ttgagctcgg gagtttgagg ctgcagtgat tcatgattgc accactgcct tccagcagcc     3240

tgatgacaga gtgggactcc atctctttac atatgtatat cttactctct tgatgggaca     3300

agttggtaga aataaagatt ttttttttct gttgtgattt cggtgtctga ccaattttct     3360

gactcattgt gaaggtgacc agatatgaag gcatatatat gactactcct ctgtccctta     3420

ggtgtataag acttagctgg aatccaacta aagatttggg ctggtctctc catcttaacg     3480

ttgatgggat tcaggacaca taaccccaaa atattgcacc ctgttatttg agaaaactgc     3540

agaagcaagg tttctcatac cttcccctta ccccttctcc cctgaagcag gccataaacc     3600

ctaagtgact gttccctgaa gtagatcata aaaccttcat tccataggta ccctttatcc     3660

tcacagatac agagacacca agaagaatct ggacaaatag gacttgctaa gttctccaca     3720

gtttattacc attagattat gtccttttgt cctctgatta tacttctgca taagactgta     3780

cataaaaata cacaagtttt cctatttctt ttttgtcttc atttctgaag attcctgtca     3840

tgtaaaactt acagtaaata aatgtgtgtg cttttctcaa taa                       3883


<210>  324
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Ala Ser Leu Asp Arg Val Lys Val Leu Val Leu Gly Asp Ser Gly 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Val His Leu Leu Cys Gln Asn Gln Val Leu 
            20                  25                  30          


Gly Asn Pro Ser Trp Thr Val Gly Cys Ser Val Asp Val Arg Val His 
        35                  40                  45              


Asp Tyr Lys Glu Gly Thr Pro Glu Glu Lys Thr Tyr Tyr Ile Glu Leu 
    50                  55                  60                  


Trp Asp Val Gly Gly Ser Val Gly Ser Ala Ser Ser Val Lys Ser Thr 
65                  70                  75                  80  


Arg Ala Val Phe Tyr Asn Ser Val Asn Gly Ile Ile Phe Val His Asp 
                85                  90                  95      


Leu Thr Asn Lys Lys Ser Ser Gln Asn Leu Arg Arg Trp Ser Leu Glu 
            100                 105                 110         


Ala Leu Asn Arg Asp Leu Val Pro Thr Gly Val Leu Val Thr Asn Gly 
        115                 120                 125             


Asp Tyr Asp Gln Glu Gln Phe Ala Asp Asn Gln Ile Pro Leu Leu Val 
    130                 135                 140                 


Ile Gly Thr Lys Leu Asp Gln Ile His Glu Thr Lys Arg His Glu Val 
145                 150                 155                 160 


Leu Thr Arg Thr Ala Phe Leu Ala Glu Asp Phe Asn Pro Glu Glu Ile 
                165                 170                 175     


Asn Leu Asp Cys Thr Asn Pro Arg Tyr Leu Ala Ala Gly Ser Ser Asn 
            180                 185                 190         


Ala Val Lys Leu Ser Arg Phe Phe Asp Lys Val Ile Glu Lys Arg Tyr 
        195                 200                 205             


Phe Leu Arg Glu Gly Asn Gln Ile Pro Gly Phe Pro Asp Arg Lys Arg 
    210                 215                 220                 


Phe Gly Ala Gly Thr Leu Lys Ser Leu His Tyr Asp 
225                 230                 235     


<210>  325
<211>  1888
<212>  DNA
<213>  Homo sapiens

<400>  325
gttgctttgc ggcgttttcc gcggggaaac tgtgtaaagg gtggggaaac ttgaaagttg       60

gatgctgcag acccggcatg ggtagcaaga aactaaaacg agtgggttta tcacaagagc      120

tgtgtgaccg tctgagtaga catcagatcc ttacctgtca ggacttttta tgtctttccc      180

cactggagct tatgaaggtg actggtctga gttatcgagg tgtccatgaa cttctatgta      240

tggtcagcag ggcctgtgcc ccaaagatgc aaacggctta tgggataaaa gcacaaaggt      300

ctgctgattt ctcaccagca ttcttatcta ctaccctttc tgctttggac gaagccctgc      360

atggtggtgt ggcttgtgga tccctcacag agattacagg tccaccaggt tgtggaaaaa      420

ctcagttttg tataatgatg agcattttgg ctacattacc caccaacatg ggaggattag      480

aaggagctgt ggtgtacatt gacacagagt ctgcatttag tgctgaaaga ctggttgaaa      540

tagcagaatc ccgttttccc agatatttta acactgaaga aaagttactt ttgacaagta      600

gtaaagttca tctttatcgg gaactcacct gtgatgaagt tctacaaagg attgaatctt      660

tggaagaaga aattatctca aaaggaatta aacttgtgat tcttgactct gttgcttctg      720

tggtcagaaa ggagtttgat gcacaacttc aaggcaatct caaagaaaga aacaagttct      780

tggcaagaga ggcatcctcc ttgaagtatt tggctgagga gttttcaatc ccagttatct      840

tgacgaatca gattacaacc catctgagtg gagccctggc ttctcaggca gacctggtgt      900

ctccagctga tgatttgtcc ctgtctgaag gcacttctgg atccagctgt gtgatagccg      960

cactaggaaa tacctggagt cacagtgtga atacccggct gatcctccag taccttgatt     1020

cagagagaag acagattctt attgccaagt cccctctggc tcccttcacc tcatttgtct     1080

acaccatcaa ggaggaaggc ctggttcttc aagcctatgg aaattcctag agacagataa     1140

atgtgcaaac ctgttcatct tgccaagaaa aatccgcttt tctgccacag aaacaaaata     1200

ttgggaaaga gtcttgtggt gaaacaccca tcgttctctg ctaaaacatt tggttgctac     1260

tgtgtagact cagcttaagt catggaattc tagaggatgt atctcacaag taggatcaag     1320

aacaagccca acagtaatct gcatcataag ctgatttgat accatggcac tgacaatggg     1380

cactgatttg ataccatggc actgacaatg ggcacacagg gaacaggaaa tgggaatgag     1440

agcaagggtt gggttgtgtt cgtggaacac ataggttttt tttttttaac tttctctttc     1500

taaaatattt cattttgatg gaggtgaaat ttatataaga tgaaattaac cattttaaag     1560

taaacaattc cgtggcaact agatatcatg atgtgcaacc agcatctctg tctagttcca     1620

aatattttca tcaccccaaa agcaagaccc ataaccatta tgcaagtgtt cctatttccc     1680

cctcctccca gctcctggaa acccaccaat ctactttgtt gctatggctt tacctattct     1740

ggatatttca tataaatgga atcatatagt gtctgtcttc tttcactagt atgttttcaa     1800

gtctcctcca tggtgtagcg tgcatcagta cttcattctt tttatggctg aataatattg     1860

cattgtcagg aaaaaaaaaa aaaaaaaa                                        1888


<210>  326
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Ala Tyr Gly Asn Ser 
            340                 345                 350 


<210>  327
<211>  2513
<212>  DNA
<213>  Homo sapiens

<400>  327
gttttccgcg gggaaactgt gtaaagggtg gggaaacttg aaagttggat gctgcagacc       60

cggcatgggt agcaagaaac taaaacgagt gggtttatca caagagctgt gtgaccgtct      120

gagtagacat cagatcctta cctgtcagga ctttttatgt ctttccccac tggagcttat      180

gaaggtgact ggtctgagtt atcgaggtgt ccatgaactt ctatgtatgg tcagcagggc      240

ctgtgcccca aagatgcaaa cggcttatgg gataaaagca caaaggtctg ctgatttctc      300

accagcattc ttatctacta ccctttctgc tttggacgaa gccctgcatg gtggtgtggc      360

ttgtggatcc ctcacagaga ttacaggtcc accaggttgt ggaaaaactc agttttgtat      420

aatgatgagc attttggcta cattacccac caacatggga ggattagaag gagctgtggt      480

gtacattgac acagagtctg catttagtgc tgaaagactg gttgaaatag cagaatcccg      540

ttttcccaga tattttaaca ctgaagaaaa gttacttttg acaagtagta aagttcatct      600

ttatcgggaa ctcacctgtg atgaagttct acaaaggatt gaatctttgg aagaagaaat      660

tatctcaaaa ggaattaaac ttgtgattct tgactctgtt gcttctgtgg tcagaaagga      720

gtttgatgca caacttcaag gcaatctcaa agaaagaaac aagttcttgg caagagaggc      780

atcctccttg aagtatttgg ctgaggagtt ttcaatccca gttatcttga cgaatcagat      840

tacaacccat ctgagtggag ccctggcttc tcaggcagac ctggtgtctc cagctgatga      900

tttgtccctg tctgaaggca cttctggatc cagctgtgtg atagccgcac taggaaatac      960

ctggagtcac agtgtgaata cccggctgat cctccagtac cttgattcag agagaagaca     1020

gattcttatt gccaagtccc ctctggctcc cttcacctca tttgtctaca ccatcaagga     1080

ggaaggcctg gttcttcaag agacaacatt ttgctctgtc acccaagctg aactgaactg     1140

ggctccagaa atcctcccac ctcagcctcc tgagcagcta ggactacaga tgtgccacca     1200

tacccagcta attttttaat tttttgtaga ggtggggtct cattatgttg cccaagctga     1260

tctcaaactc ctggcttcaa gagatccacc cacctcagcc tcccaaagcg ctaggattac     1320

aagtatgaga ctttgccatt ccaatgagaa ttttgtcctt agcaatctca tccaatggcc     1380

actggagatg tgtgtagggc cacaagaatg agaaaggggg caatggagtg acaggtgacc     1440

tgctcaggtg cccctcccca gaccaaatgt cccaggcaca cagcccatgc cctccaccat     1500

ggagtacatt ttctccctgg cttgctgctg agctaaagga ccagggacgt ggaaacagga     1560

ggtgaactaa ggcaccccgc cacccactgt ggcagcttga atttcttgag gctgagacaa     1620

actaggatcc agtagcctag attttgcccc agtttctcca ctgagtattt actcagtgct     1680

cctgagccga tgccttcccc tctgcctaga tgaaccacag cattttggta aatgcctcag     1740

catgttagga gcgctggaac gtttattctc ttccctccca attatccact ctaatggagc     1800

agaacactta catggaaaat cctaaacatg gaagatgatt taaaaatgat tcaccctgga     1860

atacatgctt ccagttgctt ctacaggttt accttgctaa aggcatttcg cttcctttgc     1920

tgttacaata agcttgcctg ccttgaagaa aagaagacca gggccaaagg gaaatcagtc     1980

aagggagcct gttttgtctg aaataatgca tccatgaaca aatgaattga gtataactgt     2040

ctttttacat cagtgtttct gtggaattaa gagaacatcc aaggccactc ctagcttgag     2100

tagattaaat ttgtccttgt gtttggagca agggttgtga agtctgtctg gcccatcaaa     2160

tgaccaatgg cttttaagga aggactaagt gacttatgac cagaacaagg gagcagcctg     2220

agtcagtctc cccaatgtct acattgtgtt atttatacta gcaaaaaaat agacacaact     2280

aaatgttcga ccatatggta ttggttaaat taacatctat acgatggaat actagatggt     2340

cattaaaatt atgtgtcaga agaaggctta atctcatggg aaagtgttca caccatatta     2400

ttaaagagaa aaaacagatt ataaagcaat atgcatacaa tgtagtagtt ctgtaagaaa     2460

aaagtattat gtgcatttta actggaaaaa tatgtataaa aatgttaaca gtg            2513


<210>  328
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Glu Thr Thr Phe Cys Ser Val 
            340                 345                 350         


Thr Gln Ala Glu Leu Asn Trp Ala Pro Glu Ile Leu Pro Pro Gln Pro 
        355                 360                 365             


Pro Glu Gln Leu Gly Leu Gln Met Cys His His Thr Gln Leu Ile Phe 
    370                 375                 380                 


<210>  329
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  329
gttttccgcg gggaaactgt gtaaagggtg gggaaacttg aaagttggat gctgcagacc       60

cggcatgggt agcaagaaac taaaacgagt gggtttatca caagagctgt gtgaccgtct      120

gagtagacat cagatcctta cctgtcagga ctttttatgt ctttccccac tggagcttat      180

gaaggtgact ggtctgagtt atcgaggtgt ccatgaactt ctatgtatgg tcagcagggc      240

ctgtgcccca aagatgcaaa cggcttatgg gataaaagca caaaggtctg ctgatttctc      300

accagcattc ttatctacta ccctttctgc tttggacgaa gccctgcatg gtggtgtggc      360

ttgtggatcc ctcacagaga ttacaggtcc accaggttgt ggaaaaactc agttttgtat      420

aatgatgagc attttggcta cattacccac caacatggga ggattagaag gagctgtggt      480

gtacattgac acagagtctg catttagtgc tgaaagactg gttgaaatag cagaatcccg      540

ttttcccaga tattttaaca ctgaagaaaa gttacttttg acaagtagta aagttcatct      600

ttatcgggaa ctcacctgtg atgaagttct acaaaggatt gaatctttgg aagaagaaat      660

tatctcaaaa ggaattaaac ttgtgattct tgactctgtt gcttctgtgg tcagaaagga      720

gtttgatgca caacttcaag gcaatctcaa agaaagaaac aagttcttgg caagagaggc      780

atcctccttg aagtatttgg ctgaggagtt ttcaatccca gttatcttga cgaatcagat      840

tacaacccat ctgagtggag ccctggcttc tcaggcagac ctggtgtctc cagctgatga      900

tttgtccctg tctgaaggca cttctggatc cagctgtgtg atagccgcac taggaaatac      960

ctggagtcac agtgtgaata cccggctgat cctccagtac cttgattcag agagaagaca     1020

gattcttatt gccaagtccc ctctggctcc cttcacctca tttgtctaca ccatcaagga     1080

ggaaggcctg gttcttcaag gccaagagaa gccataggga tactgtgacc tttgtctaga     1140

gttgatgggg gtgtgatttg tgaaataaaa caggaccgta ctgcttggaa gaaggaaacg     1200

gaagctgaca taatggggat taattagttg attgctgttg agatggtaac agatttgctc     1260

ctaaaccatt gagctagcga tttcagacct agcagggaag gtgaagatga agaagccttt     1320

gttcaggtct ctagatgtgt agggctgagg gctttgccgc catgggatgt caacagccat     1380

aataataatt tgcacttata tagcaccttt caaccaggca cctcaaagcg gtttaaccac     1440

attaattaat taaagcccac aatcctcctg gggagaggag gaggatgact aacaagattt     1500

gtaattacag gagggaacat ttccgaataa agtattgtct accagaaaaa aaaaaaaaaa     1560

aaaaaa                                                                1566


<210>  330
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Gly Ser Lys Lys Leu Lys Arg Val Gly Leu Ser Gln Glu Leu Cys 
1               5                   10                  15      


Asp Arg Leu Ser Arg His Gln Ile Leu Thr Cys Gln Asp Phe Leu Cys 
            20                  25                  30          


Leu Ser Pro Leu Glu Leu Met Lys Val Thr Gly Leu Ser Tyr Arg Gly 
        35                  40                  45              


Val His Glu Leu Leu Cys Met Val Ser Arg Ala Cys Ala Pro Lys Met 
    50                  55                  60                  


Gln Thr Ala Tyr Gly Ile Lys Ala Gln Arg Ser Ala Asp Phe Ser Pro 
65                  70                  75                  80  


Ala Phe Leu Ser Thr Thr Leu Ser Ala Leu Asp Glu Ala Leu His Gly 
                85                  90                  95      


Gly Val Ala Cys Gly Ser Leu Thr Glu Ile Thr Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Gln Phe Cys Ile Met Met Ser Ile Leu Ala Thr Leu Pro 
        115                 120                 125             


Thr Asn Met Gly Gly Leu Glu Gly Ala Val Val Tyr Ile Asp Thr Glu 
    130                 135                 140                 


Ser Ala Phe Ser Ala Glu Arg Leu Val Glu Ile Ala Glu Ser Arg Phe 
145                 150                 155                 160 


Pro Arg Tyr Phe Asn Thr Glu Glu Lys Leu Leu Leu Thr Ser Ser Lys 
                165                 170                 175     


Val His Leu Tyr Arg Glu Leu Thr Cys Asp Glu Val Leu Gln Arg Ile 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Ile Ile Ser Lys Gly Ile Lys Leu Val Ile 
        195                 200                 205             


Leu Asp Ser Val Ala Ser Val Val Arg Lys Glu Phe Asp Ala Gln Leu 
    210                 215                 220                 


Gln Gly Asn Leu Lys Glu Arg Asn Lys Phe Leu Ala Arg Glu Ala Ser 
225                 230                 235                 240 


Ser Leu Lys Tyr Leu Ala Glu Glu Phe Ser Ile Pro Val Ile Leu Thr 
                245                 250                 255     


Asn Gln Ile Thr Thr His Leu Ser Gly Ala Leu Ala Ser Gln Ala Asp 
            260                 265                 270         


Leu Val Ser Pro Ala Asp Asp Leu Ser Leu Ser Glu Gly Thr Ser Gly 
        275                 280                 285             


Ser Ser Cys Val Ile Ala Ala Leu Gly Asn Thr Trp Ser His Ser Val 
    290                 295                 300                 


Asn Thr Arg Leu Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile 
305                 310                 315                 320 


Leu Ile Ala Lys Ser Pro Leu Ala Pro Phe Thr Ser Phe Val Tyr Thr 
                325                 330                 335     


Ile Lys Glu Glu Gly Leu Val Leu Gln Gly Gln Glu Lys Pro 
            340                 345                 350 


<210>  331
<211>  2097
<212>  DNA
<213>  Homo sapiens

<400>  331
ggtccttcag cctcgttccc gggcagtata aagtttgctg tctcctttgt tcgccctcgt       60

tgcgcagtag tgctagcggc ttcgcggttc ggtcctcgca cccggcagcc gccactggtg      120

ctgagctgct aggaagcccc tatcgccgag ctcgttggag cttgaaccca ttgtcacccc      180

tccgactcac cggcccaaaa aaaaaaaaac atggttgaag cagatcgccc aggaaagctc      240

ttcattggtg ggcttaatac ggaaacaaat gagaaagctc ttgaagcagt atttggcaaa      300

tatggacgaa tagtggaagt actcttgatg aaagaccgtg aaaccaacaa atcaagagga      360

tttgcttttg tcacctttga aagcccagca gacgctaagg atgcagccag agacatgaat      420

ggaaagtcat tagatggaaa agccatcaag gtggaacaag ccaccaaacc atcatttgaa      480

agtggtagac gtggaccgcc tccacctcca agaagtagag gccctccaag aggtcttaga      540

ggtggaagag gaggaagtgg aggaaccagg ggacctccct cacggggagg acacatggat      600

gacggtggat attccatgaa ttttaacatg agttcttcca ggggaccact cccagtaaaa      660

agaggaccac caccaagaag tgggggtcct cctcctaaga gatctgcacc ttcaggacca      720

gttcgcagta gcagtggaat gggaggaaga gctcctgtat cacgtggaag agatagttat      780

ggaggtccac ctcgaaggga accgctgccc tctcgtagag atgtttattt gtccccaaga      840

gatgatgggt attctactaa agacagctat tcaagcagag attacccaag ttctcgtgat      900

actagagatt atgcaccacc accacgagat tatacttacc gtgattatgg tcattccagt      960

tcacgtgatg actatccatc aagaggatat agcgatagag atggatatgg tcgtgatcgt     1020

gactattcag atcatccaag tggaggttcc tacagagatt catatgagag ttatggtaac     1080

tcacgtagtg ctccacctac acgagggccc ccgccatctt atggtggaag cagtcgctat     1140

gatgattaca gcagctcacg tgacggatat ggtggaagtc gagacagtta ctcaagcagc     1200

cgaagtgatc tctactcaag tggtcgtgat cgggttggca gacaagaaag agggcttccc     1260

ccttctatgg aaagggggta ccctcctcca cgtgattcct acagcagttc aagccgcgga     1320

gcaccaagag gtggtggccg tggaggaagc cgatctgata gagggggagg cagaagcaga     1380

tactagaaac aaacaaaact ttggaccaaa atcccagttc aaagaaacaa aaagtggaaa     1440

ctattctatc ataactaccc aaggactact aaaaggaaaa attgtgttac tttttttaaa     1500

ttccctgtta agttcccctc cataattttt atgttcttgt gaggaaaaaa gtaaaacatg     1560

tttaatttta tttgactttc gcattgcttt tcaacaagca aatgttaaat gtgttaagac     1620

ttgtactagt gttgtaactt tccaagtaaa agtatcccct aaaggccact tcctatctga     1680

tttttcccag caaatgaggc aggcaattct aagatcttcc acaaaacatc tagccatcta     1740

aaatggagag atgaatcatt ctacctatac aaacaagcta gctattagag ggtggttggg     1800

gtatgctact cataagattt cagggtgtct tccaactgaa atctcaatgt tctcagtacg     1860

aaaaacctga aatcacatgc ctatgtaagg aaagtgctat tcacccagta aacccaaaaa     1920

agcaaatgga taatgctggc cattttgcct ttctgacatt tccttgggaa tctgcaagaa     1980

cctccccttt cccttccccc aataagacca tttaagtgtg tgttaaacaa ctacagaata     2040

ctaaataaaa agtttggcca aaaccaacca tgaagctgca aaaaaaaaaa aaaaaaa        2097


<210>  332
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn 
1               5                   10                  15      


Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly 
            20                  25                  30          


Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser 
        35                  40                  45              


Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp 
    50                  55                  60                  


Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys 
65                  70                  75                  80  


Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Ser Gly Arg Arg Gly Pro 
                85                  90                  95      


Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Leu Arg Gly Gly 
            100                 105                 110         


Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His 
        115                 120                 125             


Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg 
    130                 135                 140                 


Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro 
145                 150                 155                 160 


Pro Pro Lys Arg Ser Ala Pro Ser Gly Pro Val Arg Ser Ser Ser Gly 
                165                 170                 175     


Met Gly Gly Arg Ala Pro Val Ser Arg Gly Arg Asp Ser Tyr Gly Gly 
            180                 185                 190         


Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser 
        195                 200                 205             


Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp 
    210                 215                 220                 


Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp 
225                 230                 235                 240 


Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro 
                245                 250                 255     


Ser Arg Gly Tyr Ser Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr 
            260                 265                 270         


Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr 
        275                 280                 285             


Gly Asn Ser Arg Ser Ala Pro Pro Thr Arg Gly Pro Pro Pro Ser Tyr 
    290                 295                 300                 


Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr 
305                 310                 315                 320 


Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser 
                325                 330                 335     


Ser Gly Arg Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser 
            340                 345                 350         


Met Glu Arg Gly Tyr Pro Pro Pro Arg Asp Ser Tyr Ser Ser Ser Ser 
        355                 360                 365             


Arg Gly Ala Pro Arg Gly Gly Gly Arg Gly Gly Ser Arg Ser Asp Arg 
    370                 375                 380                 


Gly Gly Gly Arg Ser Arg Tyr 
385                 390     


<210>  333
<211>  1224
<212>  DNA
<213>  Homo sapiens

<400>  333
cggggaccca ggccgggccc ggggagccca gtgctgagct ctagagcccg ccaggccgcc       60

gcctcctcgc gccctctgcc tttactgtca gtgtcgcccc tcgcaaagag tcatggaaga      120

cggtccgctg ccagatctca gagacatcga gctgaagctg gggcgcaaag tgcccgagag      180

cctagcgcgc tcgctgcgcg gggaggagcc ggcgccccgg gaaggggctg cggaccccag      240

cggggttggt gggagctgca gcagcagcag tagctgcagc agcttcgcgc cctccgtgtc      300

ctcctcgtct tcatcctccc ctgcctccgg ctccccacga cgtagccacc ccagcgccct      360

ggagaggcta gagaccaaac tgcacatcct caggcaggag atggtgaacc tcagagccac      420

tgacgtaagg ctcatgcgtc aattgctcct catcaatgag agcatcgagt ccatcaagtg      480

gatgattgag gaaaaggcca ccgttaccag ccgaggcagc agtctcagtg gcagcctgtg      540

tagtttgctg gagagtcaga gcacctcctt acgtggcagc tacaacagcc tccatgatgg      600

cagtgatggg ctggatggca tctcggtagg gagctacctg gacactttgg cagatgatgt      660

accaggccat cagacccctt cagacttgga tcagttcagt gacagctcta tcatagagga      720

ctctcaagct ctgcacaagc atcccaagct ggattctgag tactactgct ttggctaatg      780

atccacgttt ttgcatggga ctgatgtgca attaacttgt atgtatcctt cttctctgct      840

gctatatttt tggtgtgatt tattttaata aggcaacctt tttaaagaag cttattttta      900

aactgcttaa tgaaatttct gttgctccta atacttctca tctagactga tttatttttc      960

tctgttacat ctctattttt atttattgta ataatctttc tcccttctct tacagtagca     1020

cagacaaagt agagggggaa aataagcaat aattgtttct gcttttgttt tcagagtgag     1080

gggtcaggga ttatatgaaa cactttgcta agttttacaa taaaccaaag tctgatcact     1140

tccttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaa                                            1224


<210>  334
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Glu Asp Gly Pro Leu Pro Asp Leu Arg Asp Ile Glu Leu Lys Leu 
1               5                   10                  15      


Gly Arg Lys Val Pro Glu Ser Leu Ala Arg Ser Leu Arg Gly Glu Glu 
            20                  25                  30          


Pro Ala Pro Arg Glu Gly Ala Ala Asp Pro Ser Gly Val Gly Gly Ser 
        35                  40                  45              


Cys Ser Ser Ser Ser Ser Cys Ser Ser Phe Ala Pro Ser Val Ser Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Pro Ala Ser Gly Ser Pro Arg Arg Ser His Pro 
65                  70                  75                  80  


Ser Ala Leu Glu Arg Leu Glu Thr Lys Leu His Ile Leu Arg Gln Glu 
                85                  90                  95      


Met Val Asn Leu Arg Ala Thr Asp Val Arg Leu Met Arg Gln Leu Leu 
            100                 105                 110         


Leu Ile Asn Glu Ser Ile Glu Ser Ile Lys Trp Met Ile Glu Glu Lys 
        115                 120                 125             


Ala Thr Val Thr Ser Arg Gly Ser Ser Leu Ser Gly Ser Leu Cys Ser 
    130                 135                 140                 


Leu Leu Glu Ser Gln Ser Thr Ser Leu Arg Gly Ser Tyr Asn Ser Leu 
145                 150                 155                 160 


His Asp Gly Ser Asp Gly Leu Asp Gly Ile Ser Val Gly Ser Tyr Leu 
                165                 170                 175     


Asp Thr Leu Ala Asp Asp Val Pro Gly His Gln Thr Pro Ser Asp Leu 
            180                 185                 190         


Asp Gln Phe Ser Asp Ser Ser Ile Ile Glu Asp Ser Gln Ala Leu His 
        195                 200                 205             


Lys His Pro Lys Leu Asp Ser Glu Tyr Tyr Cys Phe Gly 
    210                 215                 220     


<210>  335
<211>  4023
<212>  DNA
<213>  Homo sapiens

<400>  335
ggagtcggag ggcggggagc tcggaggagg gcgcccggag ttgtggagac agccgatcgg       60

gaagtcgccg cgcttggccg gcgcagcccg ttctcgggct tcttcgctgc cgccctccgt      120

ctgcgccgcg ggcctcggcg ccgtggggcg gcccggggtg cgctcgcccg ccccggcccc      180

ggccactgcc gcgcgcgggc gggatgtggc gcctggtgcc cctgaagctg ggccgcctgt      240

cccgtgcact gaagctggcg gcgctcggca gcctgttggt gctgatgctg ctgcactcgc      300

cgtcgctgct cgcctcttgg cagcgcaacg agctcgccga ccggcgtttc ctgcagctca      360

ataagtgccc ggcgtgcttc ggcacgagct ggtgccgccg tttcctcaac ggccaggtgg      420

gcttcgagac gtggggccgc ctgcgcctgc tggacttcct caacgtgaag aacgtgtact      480

tcgcgcagta cggcgagccc cgcgagggcg gccgccggcg cgtggtgctc aagcgcctgg      540

gttcgcagcg cgagctggcg cagctcgacc agagcatctg caagcgggcc accggccggc      600

cgcgctgcga cctgctccag gccatgcccc gcaccgagtt cgcgcgtctc aacggcgacg      660

tgcggctgct cacgccggag gcggtggagg gttggtcaga cctggtgcac tgcccctcgc      720

agcgcttgct ggaccgcctg gtgcgccgct acgccgagac caaggactcg ggcagtttcc      780

tgctgcgcaa cctcaaggac tcggagcgca tgcagctgct gctcaccctg gccttcaacc      840

ccgagccgct ggtgctacag agttttccat ctgatgaagg ttggccattt gcaaagtatc      900

tcggagcttg tggaagaatg gtggctgtaa attacgttgg agaagaactg tggagttatt      960

ttaatgcacc atgggagaaa agagttgacc ttgcttggca gttaatggaa atagcagagc     1020

agcttacaaa caatgacttt gaatttgcac tctacctcct ggacgtcagc tttgacaatt     1080

ttgcagttgg tccaagagat gggaaggtaa tcattgtgga tgctgaaaat gttttagttg     1140

ccgacaaaag attaattaga caaaataagc ctgagaattg ggatgtatgg tatgagagca     1200

agtttgatga ctgtgacaag gaggcttgct tatcattttc gaaagaaatc ctttgtgctc     1260

gtgtcactgt ggaccacaat tactatgctg tttgtcaaaa cctcttatct agacatgcca     1320

cctggcgtgg cacttctgga ggactccttc atgatccacc aagtgaaatt gccaaagatg     1380

gccgactgga ggccttgctg gatgagtgca ccaaccccaa gaagcgctat ggccgattcc     1440

aggctgcaaa agaactgcga ggctatctag cacagttaag tcacaatgtg aggtagtcag     1500

cagtgatctt ttccttttct ttgctgaaat agcactggca aaactaaacc accaaaaaac     1560

tgcctagaat aaacaaagtg tggaagtatg gcatcagagg atgatgaact tctggtagat     1620

cttacattaa cacccgtcaa aataagacat tactgtccat caaacttctc atgatgcttc     1680

tgcaagtctg ttcttcactt tggagattgg gataccattg accgcttttt cccctcccca     1740

tacctgagtg gatgatactg ttaagctatt ggaaaggagt ctgatagtta catggcttgt     1800

gtatcaaagg gtacttggta cttagattgc atttctatca tgattttgtg aatctcttgc     1860

atttactttg aatgtcaagt tagattggcc tgttttatag gccacatttt ccttctgatg     1920

tgtaaaatca tttcccattt tttaaaagtt ttacacaacc aggttactat aggtattcat     1980

ttaaatttta atataagtag ttttcattca gtgctatgcg gtacatactt aactgttagg     2040

gcaggactcc caggtttact gtttttacag agatcttagt atttcatcat gtaaataatt     2100

tacctctccc tgaccttcta tgctttacca ttgcatgata atatcatttc aggttattta     2160

agagttaaat ccctcaatgc cagtaattat aagtatacac tgaacatggc gttcagcata     2220

tgctacaaaa tggcactgtg tcctttgcta aaaggcttca agaataatac actagcagtc     2280

tacacttcga ttgaagaaac aataaaagtc aatgttttta atgctaacta gtccaagata     2340

gtaatgcaca tgccaaagaa atattaagac acattcctat ggttaggact gaaaatagaa     2400

ttggtcacct tcttatccca cttcagtatt ttagctgtca ctcttaaatt aagatctacc     2460

tgttccttta atgctgacag ttgagctact gctgatattt aaaacgtgta taacttaaag     2520

accttcgact cttttattca ttggtagttt ttccaaaatg aatatggtga tcactgttgg     2580

aatttactta ggcatcagaa ccttttactt actgatacac taggaacttg tactgtaaag     2640

cttgtctgcc cattgtgatc ttctttaccc aattgctaaa tatcagaaca tcaaatttaa     2700

atatgtgagt agaaaaatta acaaatactg tgtaaaagtt ttgtctattt aaaagctgtt     2760

ctttgtaaaa agttggctct cactagcaca ggtaacattt ttctgtttga agttgttttt     2820

ttttgtttgc agtaaagttt ggggcagtgg gttctgggct gacttactga aatcagaaag     2880

tgattgaaac atgcacaacc aaagccaagg ttttcctttt cattcattta gcaaatatgt     2940

gttgatcctc aagccccatg ccaggtgcat ttgtagctgc tataaaccat ctgaacgtga     3000

catggtcaag taactgtcaa ctgtgtcagc ataggtactt cttaagttga catgccatta     3060

tttaggatgc ctctttcatg ttatttgatt attgtgatgg aaattctctt tgtaccacct     3120

taaattagtt tgttaatcca aagtggagga agacagcaat aaaatgaatc caagtttaaa     3180

aatgggaaga catagggtaa gagctctcta ttataaaact gattgcattg tgtttcttct     3240

tacacatcag tatattgcat agctctcaat gaaacattga cgaacttgct aagcttactt     3300

tttacaaact caaaaaatcc tttaaagggc ataggaaaaa aaatcattca acaataatac     3360

ccatttgctt ccttagagct atactaaagt atagaatttc aaaacaggac acccttagat     3420

tttccaccta ttcgtaacat ggacgctgga actcacagga gagctgtctg tggttccaca     3480

aacatcatat tttttggtga gtgactgtgg ttgtgattac agagcaagaa gtaaggctct     3540

ccaggcagtg atggctactt caggtatgac taccatgaga gactatgtgg aatttctttt     3600

atctttggag atgtttgaga agctagtaaa agaattagga atttaaaatt acagggaaaa     3660

atatgtatgt gaaaagcaat aagtattttg ttctctttgc tatccagatg ctcacactca     3720

gatatttatt atacagcagc agtctatatt tttaatcatt gcccattaat agacgcagtg     3780

aaatattttt gaatcaaaca tttggggttt gtatgtgcat ttaaattgtc ttttgtactg     3840

tatgttactg tttaatttga atattttatc agaactgtct ccctgtgcct ttataatata     3900

aagttgtttc tgcaactttt aatgatctta ataaagaata ctttaagaac catattttgc     3960

taactctgtc ttcaactctg caagtttttc ttgagcaaaa aacaaataaa aaattagtta     4020

att                                                                   4023


<210>  336
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Trp Arg Leu Val Pro Leu Lys Leu Gly Arg Leu Ser Arg Ala Leu 
1               5                   10                  15      


Lys Leu Ala Ala Leu Gly Ser Leu Leu Val Leu Met Leu Leu His Ser 
            20                  25                  30          


Pro Ser Leu Leu Ala Ser Trp Gln Arg Asn Glu Leu Ala Asp Arg Arg 
        35                  40                  45              


Phe Leu Gln Leu Asn Lys Cys Pro Ala Cys Phe Gly Thr Ser Trp Cys 
    50                  55                  60                  


Arg Arg Phe Leu Asn Gly Gln Val Gly Phe Glu Thr Trp Gly Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Phe Leu Asn Val Lys Asn Val Tyr Phe Ala Gln Tyr 
                85                  90                  95      


Gly Glu Pro Arg Glu Gly Gly Arg Arg Arg Val Val Leu Lys Arg Leu 
            100                 105                 110         


Gly Ser Gln Arg Glu Leu Ala Gln Leu Asp Gln Ser Ile Cys Lys Arg 
        115                 120                 125             


Ala Thr Gly Arg Pro Arg Cys Asp Leu Leu Gln Ala Met Pro Arg Thr 
    130                 135                 140                 


Glu Phe Ala Arg Leu Asn Gly Asp Val Arg Leu Leu Thr Pro Glu Ala 
145                 150                 155                 160 


Val Glu Gly Trp Ser Asp Leu Val His Cys Pro Ser Gln Arg Leu Leu 
                165                 170                 175     


Asp Arg Leu Val Arg Arg Tyr Ala Glu Thr Lys Asp Ser Gly Ser Phe 
            180                 185                 190         


Leu Leu Arg Asn Leu Lys Asp Ser Glu Arg Met Gln Leu Leu Leu Thr 
        195                 200                 205             


Leu Ala Phe Asn Pro Glu Pro Leu Val Leu Gln Ser Phe Pro Ser Asp 
    210                 215                 220                 


Glu Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val 
225                 230                 235                 240 


Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro 
                245                 250                 255     


Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu 
            260                 265                 270         


Gln Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val 
        275                 280                 285             


Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile 
    290                 295                 300                 


Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln 
305                 310                 315                 320 


Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp 
                325                 330                 335     


Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala 
            340                 345                 350         


Arg Val Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu 
        355                 360                 365             


Ser Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp 
    370                 375                 380                 


Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp 
385                 390                 395                 400 


Glu Cys Thr Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys 
                405                 410                 415     


Glu Leu Arg Gly Tyr Leu Ala Gln Leu Ser His Asn Val Arg 
            420                 425                 430 


<210>  337
<211>  4373
<212>  DNA
<213>  Homo sapiens

<400>  337
atgggcgacg acttaacatt aacaaggtct cttcaaactt tgccagagct aaagtctaaa       60

agacaagggt catcgccaca gcaacgcgtc ctggccgcaa ggcaggcctg ggcccagcct      120

gagaagcgag ggggaaccaa gctcctcagg gacccgacgg gcggcgccgc ttctggagtg      180

agaggcgccc ggactcccca ctcgcccccg cgcgcgctgc tcgcccggga ccagcaggcg      240

cagctcaagc gtcccgggcg agagtgcgcg tgcgcgcgac cgcgggtccc gcgctccctc      300

ccccccctcc gcgcctctat aacttggcgg gcaaggaggc ggcgcccgcg gagtcggagg      360

gcggggagct cggaggaggg cgcccggagt tgtggagaca gccgatcggg aagtcgccgc      420

gcttggccgg cgcagcccgt tctcgggctt cttcgctgcc gccctccgtc tgcgccgcgg      480

gcctcggcgc cgtggggcgg cccggggtgc gctcgcccgc cccggccccg gccactgccg      540

cgcgcgggcg ggatgtggcg cctggtgccc ctgaagctgg gccgcctgtc ccgtgcactg      600

aagctggcgg cgctcggcag cctgttggtg ctgatgctgc tgcactcgcc gtcgctgctc      660

gcctcttggc agcgcaacga gctcgccgac cggcgtttcc tgcagctcaa taagtgcccg      720

gcgtgcttcg gcacgagctg gtgccgccgt ttcctcaacg gccaggtggg cttcgagacg      780

tggggccgcc tgcgcctgct ggacttcctc aacgtgaaga acgtgtactt cgcgcagtac      840

ggcgagcccc gcgagggcgg ccgccggcgc gtggtgctca agcgcctggg ttcgcagcgc      900

gagctggcgc agctcgacca gagcatctgc aagcgggcca ccggccggcc gcgctgcgac      960

ctgctccagg ccatgccccg caccgagttc gcgcgtctca acggcgacgt gcggctgctc     1020

acgccggagg cggtggaggg ttggtcagac ctggtgcact gcccctcgca gcgcttgctg     1080

gaccgcctgg tgcgccgcta cgccgagacc aaggactcgg gcagtttcct gctgcgcaac     1140

ctcaaggact cggagcgcat gcagctgctg ctcaccctgg ccttcaaccc cgagccgctg     1200

gtgctacaga gttttccatc tgatgaaggt tggccatttg caaagtatct cggagcttgt     1260

ggaagaatgg tggctgtaaa ttacgttgga gaagaactgt ggagttattt taatgcacca     1320

tgggagaaaa gagttgacct tgcttggcag ttaatggaaa tagcagagca gcttacaaac     1380

aatgactttg aatttgcact ctacctcctg gacgtcagct ttgacaattt tgcagttggt     1440

ccaagagatg ggaaggtaat cattgtggat gctgaaaatg ttttagttgc cgacaaaaga     1500

ttaattagac aaaataagcc tgagaattgg gatgtatggt atgagagcaa gtttgatgac     1560

tgtgacaagg aggcttgctt atcattttcg aaagaaatcc tttgtgctcg tgtcactgtg     1620

gaccacaatt actatgctgt ttgtcaaaac ctcttatcta gacatgccac ctggcgtggc     1680

acttctggag gactccttca tgatccacca agtgaaattg ccaaagatgg ccgactggag     1740

gccttgctgg atgagtgcac caaccccaag aagcgctatg gccgattcca ggctgcaaaa     1800

gaactgcgag gctatctagc acagttaagt cacaatgtga ggtagtcagc agtgatcttt     1860

tccttttctt tgctgaaata gcactggcaa aactaaacca ccaaaaaact gcctagaata     1920

aacaaagtgt ggaagtatgg catcagagga tgatgaactt ctggtagatc ttacattaac     1980

acccgtcaaa ataagacatt actgtccatc aaacttctca tgatgcttct gcaagtctgt     2040

tcttcacttt ggagattggg ataccattga ccgctttttc ccctccccat acctgagtgg     2100

atgatactgt taagctattg gaaaggagtc tgatagttac atggcttgtg tatcaaaggg     2160

tacttggtac ttagattgca tttctatcat gattttgtga atctcttgca tttactttga     2220

atgtcaagtt agattggcct gttttatagg ccacattttc cttctgatgt gtaaaatcat     2280

ttcccatttt ttaaaagttt tacacaacca ggttactata ggtattcatt taaattttaa     2340

tataagtagt tttcattcag tgctatgcgg tacatactta actgttaggg caggactccc     2400

aggtttactg tttttacaga gatcttagta tttcatcatg taaataattt acctctccct     2460

gaccttctat gctttaccat tgcatgataa tatcatttca ggttatttaa gagttaaatc     2520

cctcaatgcc agtaattata agtatacact gaacatggcg ttcagcatat gctacaaaat     2580

ggcactgtgt cctttgctaa aaggcttcaa gaataataca ctagcagtct acacttcgat     2640

tgaagaaaca ataaaagtca atgtttttaa tgctaactag tccaagatag taatgcacat     2700

gccaaagaaa tattaagaca cattcctatg gttaggactg aaaatagaat tggtcacctt     2760

cttatcccac ttcagtattt tagctgtcac tcttaaatta agatctacct gttcctttaa     2820

tgctgacagt tgagctactg ctgatattta aaacgtgtat aacttaaaga ccttcgactc     2880

ttttattcat tggtagtttt tccaaaatga atatggtgat cactgttgga atttacttag     2940

gcatcagaac cttttactta ctgatacact aggaacttgt actgtaaagc ttgtctgccc     3000

attgtgatct tctttaccca attgctaaat atcagaacat caaatttaaa tatgtgagta     3060

gaaaaattaa caaatactgt gtaaaagttt tgtctattta aaagctgttc tttgtaaaaa     3120

gttggctctc actagcacag gtaacatttt tctgtttgaa gttgtttttt tttgtttgca     3180

gtaaagtttg gggcagtggg ttctgggctg acttactgaa atcagaaagt gattgaaaca     3240

tgcacaacca aagccaaggt tttccttttc attcatttag caaatatgtg ttgatcctca     3300

agccccatgc caggtgcatt tgtagctgct ataaaccatc tgaacgtgac atggtcaagt     3360

aactgtcaac tgtgtcagca taggtacttc ttaagttgac atgccattat ttaggatgcc     3420

tctttcatgt tatttgatta ttgtgatgga aattctcttt gtaccacctt aaattagttt     3480

gttaatccaa agtggaggaa gacagcaata aaatgaatcc aagtttaaaa atgggaagac     3540

atagggtaag agctctctat tataaaactg attgcattgt gtttcttctt acacatcagt     3600

atattgcata gctctcaatg aaacattgac gaacttgcta agcttacttt ttacaaactc     3660

aaaaaatcct ttaaagggca taggaaaaaa aatcattcaa caataatacc catttgcttc     3720

cttagagcta tactaaagta tagaatttca aaacaggaca cccttagatt ttccacctat     3780

tcgtaacatg gacgctggaa ctcacaggag agctgtctgt ggttccacaa acatcatatt     3840

ttttggtgag tgactgtggt tgtgattaca gagcaagaag taaggctctc caggcagtga     3900

tggctacttc aggtatgact accatgagag actatgtgga atttctttta tctttggaga     3960

tgtttgagaa gctagtaaaa gaattaggaa tttaaaatta cagggaaaaa tatgtatgtg     4020

aaaagcaata agtattttgt tctctttgct atccagatgc tcacactcag atatttatta     4080

tacagcagca gtctatattt ttaatcattg cccattaata gacgcagtga aatatttttg     4140

aatcaaacat ttggggtttg tatgtgcatt taaattgtct tttgtactgt atgttactgt     4200

ttaatttgaa tattttatca gaactgtctc cctgtgcctt tataatataa agttgtttct     4260

gcaactttta atgatcttaa taaagaatac tttaagaacc atattttgct aactctgtct     4320

tcaactctgc aagtttttct tgagcaaaaa acaaataaaa aattagttaa ttc            4373


<210>  338
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Gly Asp Asp Leu Thr Leu Thr Arg Ser Leu Gln Thr Leu Pro Glu 
1               5                   10                  15      


Leu Lys Ser Lys Arg Gln Gly Ser Ser Pro Gln Gln Arg Val Leu Ala 
            20                  25                  30          


Ala Arg Gln Ala Trp Ala Gln Pro Glu Lys Arg Gly Gly Thr Lys Leu 
        35                  40                  45              


Leu Arg Asp Pro Thr Gly Gly Ala Ala Ser Gly Val Arg Gly Ala Arg 
    50                  55                  60                  


Thr Pro His Ser Pro Pro Arg Ala Leu Leu Ala Arg Asp Gln Gln Ala 
65                  70                  75                  80  


Gln Leu Lys Arg Pro Gly Arg Glu Cys Ala Cys Ala Arg Pro Arg Val 
                85                  90                  95      


Pro Arg Ser Leu Pro Pro Leu Arg Ala Ser Ile Thr Trp Arg Ala Arg 
            100                 105                 110         


Arg Arg Arg Pro Arg Ser Arg Arg Ala Gly Ser Ser Glu Glu Gly Ala 
        115                 120                 125             


Arg Ser Cys Gly Asp Ser Arg Ser Gly Ser Arg Arg Ala Trp Pro Ala 
    130                 135                 140                 


Gln Pro Val Leu Gly Leu Leu Arg Cys Arg Pro Pro Ser Ala Pro Arg 
145                 150                 155                 160 


Ala Ser Ala Pro Trp Gly Gly Pro Gly Cys Ala Arg Pro Pro Arg Pro 
                165                 170                 175     


Arg Pro Leu Pro Arg Ala Gly Gly Met Trp Arg Leu Val Pro Leu Lys 
            180                 185                 190         


Leu Gly Arg Leu Ser Arg Ala Leu Lys Leu Ala Ala Leu Gly Ser Leu 
        195                 200                 205             


Leu Val Leu Met Leu Leu His Ser Pro Ser Leu Leu Ala Ser Trp Gln 
    210                 215                 220                 


Arg Asn Glu Leu Ala Asp Arg Arg Phe Leu Gln Leu Asn Lys Cys Pro 
225                 230                 235                 240 


Ala Cys Phe Gly Thr Ser Trp Cys Arg Arg Phe Leu Asn Gly Gln Val 
                245                 250                 255     


Gly Phe Glu Thr Trp Gly Arg Leu Arg Leu Leu Asp Phe Leu Asn Val 
            260                 265                 270         


Lys Asn Val Tyr Phe Ala Gln Tyr Gly Glu Pro Arg Glu Gly Gly Arg 
        275                 280                 285             


Arg Arg Val Val Leu Lys Arg Leu Gly Ser Gln Arg Glu Leu Ala Gln 
    290                 295                 300                 


Leu Asp Gln Ser Ile Cys Lys Arg Ala Thr Gly Arg Pro Arg Cys Asp 
305                 310                 315                 320 


Leu Leu Gln Ala Met Pro Arg Thr Glu Phe Ala Arg Leu Asn Gly Asp 
                325                 330                 335     


Val Arg Leu Leu Thr Pro Glu Ala Val Glu Gly Trp Ser Asp Leu Val 
            340                 345                 350         


His Cys Pro Ser Gln Arg Leu Leu Asp Arg Leu Val Arg Arg Tyr Ala 
        355                 360                 365             


Glu Thr Lys Asp Ser Gly Ser Phe Leu Leu Arg Asn Leu Lys Asp Ser 
    370                 375                 380                 


Glu Arg Met Gln Leu Leu Leu Thr Leu Ala Phe Asn Pro Glu Pro Leu 
385                 390                 395                 400 


Val Leu Gln Ser Phe Pro Ser Asp Glu Gly Trp Pro Phe Ala Lys Tyr 
                405                 410                 415     


Leu Gly Ala Cys Gly Arg Met Val Ala Val Asn Tyr Val Gly Glu Glu 
            420                 425                 430         


Leu Trp Ser Tyr Phe Asn Ala Pro Trp Glu Lys Arg Val Asp Leu Ala 
        435                 440                 445             


Trp Gln Leu Met Glu Ile Ala Glu Gln Leu Thr Asn Asn Asp Phe Glu 
    450                 455                 460                 


Phe Ala Leu Tyr Leu Leu Asp Val Ser Phe Asp Asn Phe Ala Val Gly 
465                 470                 475                 480 


Pro Arg Asp Gly Lys Val Ile Ile Val Asp Ala Glu Asn Val Leu Val 
                485                 490                 495     


Ala Asp Lys Arg Leu Ile Arg Gln Asn Lys Pro Glu Asn Trp Asp Val 
            500                 505                 510         


Trp Tyr Glu Ser Lys Phe Asp Asp Cys Asp Lys Glu Ala Cys Leu Ser 
        515                 520                 525             


Phe Ser Lys Glu Ile Leu Cys Ala Arg Val Thr Val Asp His Asn Tyr 
    530                 535                 540                 


Tyr Ala Val Cys Gln Asn Leu Leu Ser Arg His Ala Thr Trp Arg Gly 
545                 550                 555                 560 


Thr Ser Gly Gly Leu Leu His Asp Pro Pro Ser Glu Ile Ala Lys Asp 
                565                 570                 575     


Gly Arg Leu Glu Ala Leu Leu Asp Glu Cys Thr Asn Pro Lys Lys Arg 
            580                 585                 590         


Tyr Gly Arg Phe Gln Ala Ala Lys Glu Leu Arg Gly Tyr Leu Ala Gln 
        595                 600                 605             


Leu Ser His Asn Val Arg 
    610                 


<210>  339
<211>  4427
<212>  DNA
<213>  Homo sapiens

<400>  339
atggcagtgg gcgagaagaa accaaagaga acctgtactg tcagggtgac ttggggtgga       60

gcagacgttg cacactggag cgaatgccac cgagtcagtg acgcagagtc tccagttatc      120

gggtcatcgc cacagcaacg cgtcctggcc gcaaggcagg cctgggccca gcctgagaag      180

cgagggggaa ccaagctcct cagggacccg acgggcggcg ccgcttctgg agtgagaggc      240

gcccggactc cccactcgcc cccgcgcgcg ctgctcgccc gggaccagca ggcgcagctc      300

aagcgtcccg ggcgagagtg cgcgtgcgcg cgaccgcggg tcccgcgctc cctccccccc      360

ctccgcgcct ctataacttg gcgggcaagg aggcggcgcc cgcggagtcg gagggcgggg      420

agctcggagg agggcgcccg gagttgtgga gacagccgat cgggaagtcg ccgcgcttgg      480

ccggcgcagc ccgttctcgg gcttcttcgc tgccgccctc cgtctgcgcc gcgggcctcg      540

gcgccgtggg gcggcccggg gtgcgctcgc ccgccccggc cccggccact gccgcgcgcg      600

ggcgggatgt ggcgcctggt gcccctgaag ctgggccgcc tgtcccgtgc actgaagctg      660

gcggcgctcg gcagcctgtt ggtgctgatg ctgctgcact cgccgtcgct gctcgcctct      720

tggcagcgca acgagctcgc cgaccggcgt ttcctgcagc tcaataagtg cccggcgtgc      780

ttcggcacga gctggtgccg ccgtttcctc aacggccagg tgggcttcga gacgtggggc      840

cgcctgcgcc tgctggactt cctcaacgtg aagaacgtgt acttcgcgca gtacggcgag      900

ccccgcgagg gcggccgccg gcgcgtggtg ctcaagcgcc tgggttcgca gcgcgagctg      960

gcgcagctcg accagagcat ctgcaagcgg gccaccggcc ggccgcgctg cgacctgctc     1020

caggccatgc cccgcaccga gttcgcgcgt ctcaacggcg acgtgcggct gctcacgccg     1080

gaggcggtgg agggttggtc agacctggtg cactgcccct cgcagcgctt gctggaccgc     1140

ctggtgcgcc gctacgccga gaccaaggac tcgggcagtt tcctgctgcg caacctcaag     1200

gactcggagc gcatgcagct gctgctcacc ctggccttca accccgagcc gctggtgcta     1260

cagagttttc catctgatga aggttggcca tttgcaaagt atctcggagc ttgtggaaga     1320

atggtggctg taaattacgt tggagaagaa ctgtggagtt attttaatgc accatgggag     1380

aaaagagttg accttgcttg gcagttaatg gaaatagcag agcagcttac aaacaatgac     1440

tttgaatttg cactctacct cctggacgtc agctttgaca attttgcagt tggtccaaga     1500

gatgggaagg taatcattgt ggatgctgaa aatgttttag ttgccgacaa aagattaatt     1560

agacaaaata agcctgagaa ttgggatgta tggtatgaga gcaagtttga tgactgtgac     1620

aaggaggctt gcttatcatt ttcgaaagaa atcctttgtg ctcgtgtcac tgtggaccac     1680

aattactatg ctgtttgtca aaacctctta tctagacatg ccacctggcg tggcacttct     1740

ggaggactcc ttcatgatcc accaagtgaa attgccaaag atggccgact ggaggccttg     1800

ctggatgagt gcaccaaccc caagaagcgc tatggccgat tccaggctgc aaaagaactg     1860

cgaggctatc tagcacagtt aagtcacaat gtgaggtagt cagcagtgat cttttccttt     1920

tctttgctga aatagcactg gcaaaactaa accaccaaaa aactgcctag aataaacaaa     1980

gtgtggaagt atggcatcag aggatgatga acttctggta gatcttacat taacacccgt     2040

caaaataaga cattactgtc catcaaactt ctcatgatgc ttctgcaagt ctgttcttca     2100

ctttggagat tgggatacca ttgaccgctt tttcccctcc ccatacctga gtggatgata     2160

ctgttaagct attggaaagg agtctgatag ttacatggct tgtgtatcaa agggtacttg     2220

gtacttagat tgcatttcta tcatgatttt gtgaatctct tgcatttact ttgaatgtca     2280

agttagattg gcctgtttta taggccacat tttccttctg atgtgtaaaa tcatttccca     2340

ttttttaaaa gttttacaca accaggttac tataggtatt catttaaatt ttaatataag     2400

tagttttcat tcagtgctat gcggtacata cttaactgtt agggcaggac tcccaggttt     2460

actgttttta cagagatctt agtatttcat catgtaaata atttacctct ccctgacctt     2520

ctatgcttta ccattgcatg ataatatcat ttcaggttat ttaagagtta aatccctcaa     2580

tgccagtaat tataagtata cactgaacat ggcgttcagc atatgctaca aaatggcact     2640

gtgtcctttg ctaaaaggct tcaagaataa tacactagca gtctacactt cgattgaaga     2700

aacaataaaa gtcaatgttt ttaatgctaa ctagtccaag atagtaatgc acatgccaaa     2760

gaaatattaa gacacattcc tatggttagg actgaaaata gaattggtca ccttcttatc     2820

ccacttcagt attttagctg tcactcttaa attaagatct acctgttcct ttaatgctga     2880

cagttgagct actgctgata tttaaaacgt gtataactta aagaccttcg actcttttat     2940

tcattggtag tttttccaaa atgaatatgg tgatcactgt tggaatttac ttaggcatca     3000

gaacctttta cttactgata cactaggaac ttgtactgta aagcttgtct gcccattgtg     3060

atcttcttta cccaattgct aaatatcaga acatcaaatt taaatatgtg agtagaaaaa     3120

ttaacaaata ctgtgtaaaa gttttgtcta tttaaaagct gttctttgta aaaagttggc     3180

tctcactagc acaggtaaca tttttctgtt tgaagttgtt tttttttgtt tgcagtaaag     3240

tttggggcag tgggttctgg gctgacttac tgaaatcaga aagtgattga aacatgcaca     3300

accaaagcca aggttttcct tttcattcat ttagcaaata tgtgttgatc ctcaagcccc     3360

atgccaggtg catttgtagc tgctataaac catctgaacg tgacatggtc aagtaactgt     3420

caactgtgtc agcataggta cttcttaagt tgacatgcca ttatttagga tgcctctttc     3480

atgttatttg attattgtga tggaaattct ctttgtacca ccttaaatta gtttgttaat     3540

ccaaagtgga ggaagacagc aataaaatga atccaagttt aaaaatggga agacataggg     3600

taagagctct ctattataaa actgattgca ttgtgtttct tcttacacat cagtatattg     3660

catagctctc aatgaaacat tgacgaactt gctaagctta ctttttacaa actcaaaaaa     3720

tcctttaaag ggcataggaa aaaaaatcat tcaacaataa tacccatttg cttccttaga     3780

gctatactaa agtatagaat ttcaaaacag gacaccctta gattttccac ctattcgtaa     3840

catggacgct ggaactcaca ggagagctgt ctgtggttcc acaaacatca tattttttgg     3900

tgagtgactg tggttgtgat tacagagcaa gaagtaaggc tctccaggca gtgatggcta     3960

cttcaggtat gactaccatg agagactatg tggaatttct tttatctttg gagatgtttg     4020

agaagctagt aaaagaatta ggaatttaaa attacaggga aaaatatgta tgtgaaaagc     4080

aataagtatt ttgttctctt tgctatccag atgctcacac tcagatattt attatacagc     4140

agcagtctat atttttaatc attgcccatt aatagacgca gtgaaatatt tttgaatcaa     4200

acatttgggg tttgtatgtg catttaaatt gtcttttgta ctgtatgtta ctgtttaatt     4260

tgaatatttt atcagaactg tctccctgtg cctttataat ataaagttgt ttctgcaact     4320

tttaatgatc ttaataaaga atactttaag aaccatattt tgctaactct gtcttcaact     4380

ctgcaagttt ttcttgagca aaaaacaaat aaaaaattag ttaattc                   4427


<210>  340
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Ala Val Gly Glu Lys Lys Pro Lys Arg Thr Cys Thr Val Arg Val 
1               5                   10                  15      


Thr Trp Gly Gly Ala Asp Val Ala His Trp Ser Glu Cys His Arg Val 
            20                  25                  30          


Ser Asp Ala Glu Ser Pro Val Ile Gly Ser Ser Pro Gln Gln Arg Val 
        35                  40                  45              


Leu Ala Ala Arg Gln Ala Trp Ala Gln Pro Glu Lys Arg Gly Gly Thr 
    50                  55                  60                  


Lys Leu Leu Arg Asp Pro Thr Gly Gly Ala Ala Ser Gly Val Arg Gly 
65                  70                  75                  80  


Ala Arg Thr Pro His Ser Pro Pro Arg Ala Leu Leu Ala Arg Asp Gln 
                85                  90                  95      


Gln Ala Gln Leu Lys Arg Pro Gly Arg Glu Cys Ala Cys Ala Arg Pro 
            100                 105                 110         


Arg Val Pro Arg Ser Leu Pro Pro Leu Arg Ala Ser Ile Thr Trp Arg 
        115                 120                 125             


Ala Arg Arg Arg Arg Pro Arg Ser Arg Arg Ala Gly Ser Ser Glu Glu 
    130                 135                 140                 


Gly Ala Arg Ser Cys Gly Asp Ser Arg Ser Gly Ser Arg Arg Ala Trp 
145                 150                 155                 160 


Pro Ala Gln Pro Val Leu Gly Leu Leu Arg Cys Arg Pro Pro Ser Ala 
                165                 170                 175     


Pro Arg Ala Ser Ala Pro Trp Gly Gly Pro Gly Cys Ala Arg Pro Pro 
            180                 185                 190         


Arg Pro Arg Pro Leu Pro Arg Ala Gly Gly Met Trp Arg Leu Val Pro 
        195                 200                 205             


Leu Lys Leu Gly Arg Leu Ser Arg Ala Leu Lys Leu Ala Ala Leu Gly 
    210                 215                 220                 


Ser Leu Leu Val Leu Met Leu Leu His Ser Pro Ser Leu Leu Ala Ser 
225                 230                 235                 240 


Trp Gln Arg Asn Glu Leu Ala Asp Arg Arg Phe Leu Gln Leu Asn Lys 
                245                 250                 255     


Cys Pro Ala Cys Phe Gly Thr Ser Trp Cys Arg Arg Phe Leu Asn Gly 
            260                 265                 270         


Gln Val Gly Phe Glu Thr Trp Gly Arg Leu Arg Leu Leu Asp Phe Leu 
        275                 280                 285             


Asn Val Lys Asn Val Tyr Phe Ala Gln Tyr Gly Glu Pro Arg Glu Gly 
    290                 295                 300                 


Gly Arg Arg Arg Val Val Leu Lys Arg Leu Gly Ser Gln Arg Glu Leu 
305                 310                 315                 320 


Ala Gln Leu Asp Gln Ser Ile Cys Lys Arg Ala Thr Gly Arg Pro Arg 
                325                 330                 335     


Cys Asp Leu Leu Gln Ala Met Pro Arg Thr Glu Phe Ala Arg Leu Asn 
            340                 345                 350         


Gly Asp Val Arg Leu Leu Thr Pro Glu Ala Val Glu Gly Trp Ser Asp 
        355                 360                 365             


Leu Val His Cys Pro Ser Gln Arg Leu Leu Asp Arg Leu Val Arg Arg 
    370                 375                 380                 


Tyr Ala Glu Thr Lys Asp Ser Gly Ser Phe Leu Leu Arg Asn Leu Lys 
385                 390                 395                 400 


Asp Ser Glu Arg Met Gln Leu Leu Leu Thr Leu Ala Phe Asn Pro Glu 
                405                 410                 415     


Pro Leu Val Leu Gln Ser Phe Pro Ser Asp Glu Gly Trp Pro Phe Ala 
            420                 425                 430         


Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala Val Asn Tyr Val Gly 
        435                 440                 445             


Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp Glu Lys Arg Val Asp 
    450                 455                 460                 


Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln Leu Thr Asn Asn Asp 
465                 470                 475                 480 


Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser Phe Asp Asn Phe Ala 
                485                 490                 495     


Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val Asp Ala Glu Asn Val 
            500                 505                 510         


Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn Lys Pro Glu Asn Trp 
        515                 520                 525             


Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys Asp Lys Glu Ala Cys 
    530                 535                 540                 


Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg Val Thr Val Asp His 
545                 550                 555                 560 


Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser Arg His Ala Thr Trp 
                565                 570                 575     


Arg Gly Thr Ser Gly Gly Leu Leu His Asp Pro Pro Ser Glu Ile Ala 
            580                 585                 590         


Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu Cys Thr Asn Pro Lys 
        595                 600                 605             


Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys Glu Leu Arg Gly Tyr Leu 
    610                 615                 620                 


Ala Gln Leu Ser His Asn Val Arg 
625                 630         


<210>  341
<211>  3986
<212>  DNA
<213>  Homo sapiens

<400>  341
cgaaagctgt cgtggaggcg gagggaggag aaatgggcgg gaggccttgg agatagctag       60

agacccggcg aataccaggt tgtcatggag tcatggggcc catctcgcgc atgcgccagc      120

taacccgccg ggctggtcat ggagcggcga ccctggccct agagtaatcc atatgcaaag      180

actacctgtg atccagcttc cagccctctt agacatggag aggaaagtcc catcgagaga      240

gagccccaga agactctctg ccaagccagg ccgaggcacg gagatgaaaa aactagcccg      300

accacttggt gtggtggctg ctgactcaga caaggactcc ggcttttcag atgggagctc      360

agaatgtctg agctctgccg agcagatgga gtcagaggac gtggtgagcg ccctgggctg      420

gagcagagag gacaagctga ggcagaacgc cagagcggca aaccacgcct tccccacact      480

gtcccctatg gttgtcatga agaacgtgct ggtcaagcag ggcagcagct catcccagct      540

ccagtcctgg actgtccagc cctcctttga agtgatctca gcgcagccac agctctttgt      600

ccttcatcca cctgtgccat ctcctgtcag cccatgccac actggtgaga aaaagtcaga      660

gtccagaaac tacttgccca ttctaaattc ttataccaaa atagccccgc acccaggcaa      720

aaggggcctc agctccgaag aaagaggaac aagtggggca ccgaagaaaa tctgcgtgga      780

gagactgggg ccaagcctgt cttccagtga gccagccaag cctggccgtg tgctatccag      840

tcctttcact ccagccctac ccagctccaa gctcaccgag gactcggctc tgcaaggagt      900

gccctccctt ggggctggcg gaagcccaca gactcttcag cctgtgtcca gcagtcatgt      960

agccaaagcc cccagtctga cctttgcttc gcccgccagt cctgtatgtg catcagacag     1020

cactctgcat ggcttagaga gcagctcccc tctctcccca ctgtcagcca gttacagttc     1080

acctctgtgg gctgcggagc acctctgccg cagcccagac atcttccctg agcagaggca     1140

gaacaagcat aggcgctttc agaataccct agccgtcctc cggaagtctg gtttgctggg     1200

aatcactctg aaagccaagg agttgattcg tcagaaccaa gcaactcagg tggaactgga     1260

ccagctgaag gagcaaaccc agatgtttat agaggccacc aagagcaggg ctcctcaggc     1320

gtgggccaag ttgcaggcgt cactcacatc tgggtccagt cattcaggca gtgacctaga     1380

cacattgtct gaccccccag acatatagca cagaagcatt tccagttgtt tgagttaact     1440

cctttgcgtt cacaactaca cttgttttcc acagcctatt taagagcttt tctttctaaa     1500

gtcacccaca aagccacgtg ccagtccctg gctgctgtct taatctgtgg cccatgcaca     1560

ggttaagtgt gttaagttcg tgaggacctc cagctggaag tgtctgtgag tccctttccc     1620

ttagcctgca cgcgcttagc tggtccttgg gacaagggag agacggctgt gtctcttcta     1680

gctgttactt cccatcctcc tcctcactgt ccaggaccat ggtgcagtga catggatgag     1740

tgcacacagt gacacttgtc caacagccaa ggagtaggtg acctaaggat cccttcactg     1800

tcctccttca agtatgttag tcatggagaa aaagaagagg atgtgttttc attttaccag     1860

gtgtggtctg ttgagtgaaa cctagaatgc tttgggccag gtgcctgggg gcaagcattt     1920

accacatgag gctttgttcc ttacacttga aaggtaaggg agaaagggca aagccatctg     1980

actcacaccg atcacacact gatctcactt ataccagtag gcaaatactt cagattttta     2040

aaatatagaa tggatttaat actgtctgga attgtatttg atgaattgct tttttgattt     2100

aagggtcaaa gaaggcagca ttttggtcac tagctggaag gttttagtaa tttatgctgg     2160

aaatagcaca acccatcaga ggcttgagat gggcctgtag gatggctccg tgagtaaagg     2220

tgcttactgc caatgacctg agtctgaccc ctgaacccca tgatagaccg agggaaccta     2280

ctactgtaca tgcacataca ccatgataaa tggatataaa attaaaaata gaagtcaacg     2340

tcaaaacaag gtaaaacaat cacaagcttg agatggcttc agtgggtcct cggggtctag     2400

tgtaagtcca ccctcagctg tctcttgtct gtacctcacc cagctgtgtc tgagggaaaa     2460

atgatcatgc ttataaattt aagttaagta aaccccaggc cacagcaacc agaaaacatc     2520

cattttcaca tctgggttct cactcatgcc ctgtcatgat ggggacactg tggaacagtc     2580

ttgcaccttt gtttgatgtg ggcagcaggg ctgaagtgtg atgtccctct ctgaggctgg     2640

tcttagggtg gagagcttaa ggagatccca ttgtcttcag cttccctgtg tctaagtggt     2700

aaagatccca aggcttgtat cctgcctgtt aaaattttca tcctcctgga aatctttgtt     2760

ctttacaaat taacttgggt tttatgacca gcctcatctt tttctgcaga gagtgtgctc     2820

ttggggcttt actaggtcca gttaaggttc acatttatta catagctggt tgtaattcta     2880

acatagttta aaaagtataa gactcaggtt ggctccactg tgctcataaa gatatatgat     2940

ttagatgcga ctggtttaaa aatgatcaac ttggtaaaat ctctgttctt tggtcaacat     3000

agaattatta cttgctgttt gctttctgaa agtttctaaa atcagagtca gtgtttctgg     3060

gtaggctcga ctccttccct tgattccgtg gtattgtgtt ctgcactcca ctgggaagca     3120

tccttcctgg cagaatgttt ggcaggaagg ctgcagagac aggagcattc agagcagcct     3180

gcaccagctg tgccttactg tgtgtcagaa ggctgggagc acttgctggg agccaagtat     3240

actactgcac tggaaaagcc ctctgtggtg ctgtaagtca tgggactctc ttcccacatt     3300

cgggtttcat ttcctgtcct gtccccataa gagatgatga gagccaccgt ggatcctcac     3360

tgctgagtgg tgggagggtt ggccccgtca ctgctcctct gtgatcctag aggcacagct     3420

gcacatctct aggctgctag catagtgctc tgttcctgga gcagctggaa gcagacagac     3480

tccagtagag aatcctttga ggcccgagag cagaccagca cttagagaaa gtctggagtg     3540

gaccagaaga atcttcattg gttgcccaag gctgtgagta gcaatggcct tagtgcatgc     3600

tatgagctct tctgaagcat tatgtagggc cgttgttttc tcaaggtgag gagtcaattt     3660

taactcagac cagcccacag gagaaccctt gtcagttgta ttggcaatat cggacacagt     3720

tagaaaggtt cccgactgaa attggttata gaatgcactg tcatttgtaa tgtactacac     3780

tgtttttatt gattatggta ctgtctgacc tatcttttct ggtatgactc cttcagcaga     3840

cacattgctt ctgcccatat actgaagcga ctccttaggg tagagactac caaatgtgag     3900

ttcttctaag aaagtgtgaa gtcatgtaga aattgactgt gaaatgtcaa aaaaaaaaaa     3960

aataaaagtc atgtacttga aagcta                                          3986


<210>  342
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Gln Arg Leu Pro Val Ile Gln Leu Pro Ala Leu Leu Asp Met Glu 
1               5                   10                  15      


Arg Lys Val Pro Ser Arg Glu Ser Pro Arg Arg Leu Ser Ala Lys Pro 
            20                  25                  30          


Gly Arg Gly Thr Glu Met Lys Lys Leu Ala Arg Pro Leu Gly Val Val 
        35                  40                  45              


Ala Ala Asp Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser Ser Glu 
    50                  55                  60                  


Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Val Val Ser Ala 
65                  70                  75                  80  


Leu Gly Trp Ser Arg Glu Asp Lys Leu Arg Gln Asn Ala Arg Ala Ala 
                85                  90                  95      


Asn His Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys Asn Val 
            100                 105                 110         


Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp Thr Val 
        115                 120                 125             


Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Phe Val Leu 
    130                 135                 140                 


His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly Glu Lys 
145                 150                 155                 160 


Lys Ser Glu Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr Thr Lys 
                165                 170                 175     


Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Ser Glu Glu Arg Gly 
            180                 185                 190         


Thr Ser Gly Ala Pro Lys Lys Ile Cys Val Glu Arg Leu Gly Pro Ser 
        195                 200                 205             


Leu Ser Ser Ser Glu Pro Ala Lys Pro Gly Arg Val Leu Ser Ser Pro 
    210                 215                 220                 


Phe Thr Pro Ala Leu Pro Ser Ser Lys Leu Thr Glu Asp Ser Ala Leu 
225                 230                 235                 240 


Gln Gly Val Pro Ser Leu Gly Ala Gly Gly Ser Pro Gln Thr Leu Gln 
                245                 250                 255     


Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser Leu Thr Phe Ala 
            260                 265                 270         


Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr Leu His Gly Leu 
        275                 280                 285             


Glu Ser Ser Ser Pro Leu Ser Pro Leu Ser Ala Ser Tyr Ser Ser Pro 
    290                 295                 300                 


Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp Ile Phe Pro Glu 
305                 310                 315                 320 


Gln Arg Gln Asn Lys His Arg Arg Phe Gln Asn Thr Leu Ala Val Leu 
                325                 330                 335     


Arg Lys Ser Gly Leu Leu Gly Ile Thr Leu Lys Ala Lys Glu Leu Ile 
            340                 345                 350         


Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln Leu Lys Glu Gln 
        355                 360                 365             


Thr Gln Met Phe Ile Glu Ala Thr Lys Ser Arg Ala Pro Gln Ala Trp 
    370                 375                 380                 


Ala Lys Leu Gln Ala Ser Leu Thr Ser Gly Ser Ser His Ser Gly Ser 
385                 390                 395                 400 


Asp Leu Asp Thr Leu Ser Asp Pro Pro Asp Ile 
                405                 410     


<210>  343
<211>  3980
<212>  DNA
<213>  Homo sapiens

<400>  343
ctgtcgtgga ggcggaggga ggagaaatgg gcgggaggcc ttggagatag ctagagaccc       60

ggcgaatacc aggttgtcat ggagtcatgg ggcccatctc gcgcatgcgc cagctaaccc      120

gccgggctgg tcatggagcg gcgaccctgg ccctagagta atccatatgc aaagactacc      180

tgtgatccag cttccagccc tcttagacat ggagaggaaa gtcccatcga gagagagccc      240

cagaagactc tctgccaagc caggccgagg cacggagatg aaaaaactag cccgaccact      300

tggtgtggtg gctgctgact cagacaagga ctccggcttt tcagatggga gctcagaatg      360

tctgagctct gccgagcaga tggagtcaga ggacgtggtg agcgccctgg gctggagcag      420

agaggacaag ctgaggcaga acgccagagc ggcaaaccac gccttcccca cactgtcccc      480

tatggttgtc atgaagaacg tgctggtcaa gcagggcagc agctcatccc agctccagtc      540

ctggactgtc cagccctcct ttgaagtgat ctcagcgcag ccacagctct ttgtccttca      600

tccacctgtg ccatctcctg tcagcccatg ccacactggt gagaaaaagt cagagtccag      660

aaactacttg cccattctaa attcttatac caaaatagcc ccgcacccag gcaaaagggg      720

cctcagctcc gaagaaagag gaacaagtgg ggcaccgaag aaaatctgcg tggagagact      780

ggggccaagc ctgtcttcca gtgagccagc caagcctggc cgtgtgctat ccagtccttt      840

cactccagcc ctacccagct ccaagctcac cgaggactcg gctctgcaag gagtgccctc      900

ccttggggct ggcggaagcc cacagactct tcagcctgtg tccagcagtc atgtagccaa      960

agcccccagt ctgacctttg cttcgcccgc cagtcctgta tgtgcatcag acagcactct     1020

gcatggctta gagagcagct cccctctctc cccactgtca gccagttaca gttcacctct     1080

gtgggctgcg gagcacctct gccgcagccc agacatcttc cctgagcaga ggcagaacaa     1140

gcataggcgc tttcagaata ccctagccgt cctccggaag tctggtttgc tgggaatcac     1200

tctgaaagcc aaggagttga ttcgtcagaa ccaagcaact caggtggaac tggaccagct     1260

gaaggagcaa acccagatgt ttatagaggc caccaagagc agggctcctc aggcgtgggc     1320

caagttgcag gcgtcactca catctgggtc cagtcattca ggcagtgacc tagacacatt     1380

gtctgacccc ccagacatat agcacagaag catttccagt tgtttgagtt aactcctttg     1440

cgttcacaac tacacttgtt ttccacagcc tatttaagag cttttctttc taaagtcacc     1500

cacaaagcca cgtgccagtc cctggctgct gtcttaatct gtggcccatg cacaggttaa     1560

gtgtgttaag ttcgtgagga cctccagctg gaagtgtctg tgagtccctt tcccttagcc     1620

tgcacgcgct tagctggtcc ttgggacaag ggagagacgg ctgtgtctct tctagctgtt     1680

acttcccatc ctcctcctca ctgtccagga ccatggtgca gtgacatgga tgagtgcaca     1740

cagtgacact tgtccaacag ccaaggagta ggtgacctaa ggatcccttc actgtcctcc     1800

ttcaagtatg ttagtcatgg agaaaaagaa gaggatgtgt tttcatttta ccaggtgtgg     1860

tctgttgagt gaaacctaga atgctttggg ccaggtgcct gggggcaagc atttaccaca     1920

tgaggctttg ttccttacac ttgaaaggta agggagaaag ggcaaagcca tctgactcac     1980

accgatcaca cactgatctc acttatacca gtaggcaaat acttcagatt tttaaaatat     2040

agaatggatt taatactgtc tggaattgta tttgatgaat tgcttttttg atttaagggt     2100

caaagaaggc agcattttgg tcactagctg gaaggtttta gtaatttatg ctggaaatag     2160

cacaacccat cagaggcttg agatgggcct gtaggatggc tccgtgagta aaggtgctta     2220

ctgccaatga cctgagtctg acccctgaac cccatgatag accgagggaa cctactactg     2280

tacatgcaca tacaccatga taaatggata taaaattaaa aatagaagtc aacgtcaaaa     2340

caaggtaaaa caatcacaag cttgagatgg cttcagtggg tcctcggggt ctagtgtaag     2400

tccaccctca gctgtctctt gtctgtacct cacccagctg tgtctgaggg aaaaatgatc     2460

atgcttataa atttaagtta agtaaacccc aggccacagc aaccagaaaa catccatttt     2520

cacatctggg ttctcactca tgccctgtca tgatggggac actgtggaac agtcttgcac     2580

ctttgtttga tgtgggcagc agggctgaag tgtgatgtcc ctctctgagg ctggtcttag     2640

ggtggagagc ttaaggagat cccattgtct tcagcttccc tgtgtctaag tggtaaagat     2700

cccaaggctt gtatcctgcc tgttaaaatt ttcatcctcc tggaaatctt tgttctttac     2760

aaattaactt gggttttatg accagcctca tctttttctg cagagagtgt gctcttgggg     2820

ctttactagg tccagttaag gttcacattt attacatagc tggttgtaat tctaacatag     2880

tttaaaaagt ataagactca ggttggctcc actgtgctca taaagatata tgatttagat     2940

gcgactggtt taaaaatgat caacttggta aaatctctgt tctttggtca acatagaatt     3000

attacttgct gtttgctttc tgaaagtttc taaaatcaga gtcagtgttt ctgggtaggc     3060

tcgactcctt cccttgattc cgtggtattg tgttctgcac tccactggga agcatccttc     3120

ctggcagaat gtttggcagg aaggctgcag agacaggagc attcagagca gcctgcacca     3180

gctgtgcctt actgtgtgtc agaaggctgg gagcacttgc tgggagccaa gtatactact     3240

gcactggaaa agccctctgt ggtgctgtaa gtcatgggac tctcttccca cattcgggtt     3300

tcatttcctg tcctgtcccc ataagagatg atgagagcca ccgtggatcc tcactgctga     3360

gtggtgggag ggttggcccc gtcactgctc ctctgtgatc ctagaggcac agctgcacat     3420

ctctaggctg ctagcatagt gctctgttcc tggagcagct ggaagcagac agactccagt     3480

agagaatcct ttgaggcccg agagcagacc agcacttaga gaaagtctgg agtggaccag     3540

aagaatcttc attggttgcc caaggctgtg agtagcaatg gccttagtgc atgctatgag     3600

ctcttctgaa gcattatgta gggccgttgt tttctcaagg tgaggagtca attttaactc     3660

agaccagccc acaggagaac ccttgtcagt tgtattggca atatcggaca cagttagaaa     3720

ggttcccgac tgaaattggt tatagaatgc actgtcattt gtaatgtact acactgtttt     3780

tattgattat ggtactgtct gacctatctt ttctggtatg actccttcag cagacacatt     3840

gcttctgccc atatactgaa gcgactcctt agggtagaga ctaccaaatg tgagttcttc     3900

taagaaagtg tgaagtcatg tagaaattga ctgtgaaatg tcaaaaaaaa aaaaaataaa     3960

agtcatgtac ttgaaagcta                                                 3980


<210>  344
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Gln Arg Leu Pro Val Ile Gln Leu Pro Ala Leu Leu Asp Met Glu 
1               5                   10                  15      


Arg Lys Val Pro Ser Arg Glu Ser Pro Arg Arg Leu Ser Ala Lys Pro 
            20                  25                  30          


Gly Arg Gly Thr Glu Met Lys Lys Leu Ala Arg Pro Leu Gly Val Val 
        35                  40                  45              


Ala Ala Asp Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser Ser Glu 
    50                  55                  60                  


Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Val Val Ser Ala 
65                  70                  75                  80  


Leu Gly Trp Ser Arg Glu Asp Lys Leu Arg Gln Asn Ala Arg Ala Ala 
                85                  90                  95      


Asn His Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys Asn Val 
            100                 105                 110         


Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp Thr Val 
        115                 120                 125             


Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Phe Val Leu 
    130                 135                 140                 


His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly Glu Lys 
145                 150                 155                 160 


Lys Ser Glu Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr Thr Lys 
                165                 170                 175     


Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Ser Glu Glu Arg Gly 
            180                 185                 190         


Thr Ser Gly Ala Pro Lys Lys Ile Cys Val Glu Arg Leu Gly Pro Ser 
        195                 200                 205             


Leu Ser Ser Ser Glu Pro Ala Lys Pro Gly Arg Val Leu Ser Ser Pro 
    210                 215                 220                 


Phe Thr Pro Ala Leu Pro Ser Ser Lys Leu Thr Glu Asp Ser Ala Leu 
225                 230                 235                 240 


Gln Gly Val Pro Ser Leu Gly Ala Gly Gly Ser Pro Gln Thr Leu Gln 
                245                 250                 255     


Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser Leu Thr Phe Ala 
            260                 265                 270         


Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr Leu His Gly Leu 
        275                 280                 285             


Glu Ser Ser Ser Pro Leu Ser Pro Leu Ser Ala Ser Tyr Ser Ser Pro 
    290                 295                 300                 


Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp Ile Phe Pro Glu 
305                 310                 315                 320 


Gln Arg Gln Asn Lys His Arg Arg Phe Gln Asn Thr Leu Ala Val Leu 
                325                 330                 335     


Arg Lys Ser Gly Leu Leu Gly Ile Thr Leu Lys Ala Lys Glu Leu Ile 
            340                 345                 350         


Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln Leu Lys Glu Gln 
        355                 360                 365             


Thr Gln Met Phe Ile Glu Ala Thr Lys Ser Arg Ala Pro Gln Ala Trp 
    370                 375                 380                 


Ala Lys Leu Gln Ala Ser Leu Thr Ser Gly Ser Ser His Ser Gly Ser 
385                 390                 395                 400 


Asp Leu Asp Thr Leu Ser Asp Pro Pro Asp Ile 
                405                 410     


<210>  345
<211>  3980
<212>  DNA
<213>  Homo sapiens

<400>  345
ctgtcgtgga ggcggaggga ggagaaatgg gcgggaggcc ttggagatag ctagagaccc       60

ggcgaatacc aggttgtcat ggagtcatgg ggcccatctc gcgcatgcgc cagctaaccc      120

gccgggctgg tcatggagcg gcgaccctgg ccctagagta atccatatgc aaagactacc      180

tgtgatccag cttccagccc tcttagacat ggagaggaaa gtcccatcga gagagagccc      240

cagaagactc tctgccaagc caggccgagg cacggagatg aaaaaactag cccgaccact      300

tggtgtggtg gctgctgact cagacaagga ctccggcttt tcagatggga gctcagaatg      360

tctgagctct gccgagcaga tggagtcaga ggacgtggtg agcgccctgg gctggagcag      420

agaggacaag ctgaggcaga acgccagagc ggcaaaccac gccttcccca cactgtcccc      480

tatggttgtc atgaagaacg tgctggtcaa gcagggcagc agctcatccc agctccagtc      540

ctggactgtc cagccctcct ttgaagtgat ctcagcgcag ccacagctct ttgtccttca      600

tccacctgtg ccatctcctg tcagcccatg ccacactggt gagaaaaagt cagagtccag      660

aaactacttg cccattctaa attcttatac caaaatagcc ccgcacccag gcaaaagggg      720

cctcagctcc gaagaaagag gaacaagtgg ggcaccgaag aaaatctgcg tggagagact      780

ggggccaagc ctgtcttcca gtgagccagc caagcctggc cgtgtgctat ccagtccttt      840

cactccagcc ctacccagct ccaagctcac cgaggactcg gctctgcaag gagtgccctc      900

ccttggggct ggcggaagcc cacagactct tcagcctgtg tccagcagtc atgtagccaa      960

agcccccagt ctgacctttg cttcgcccgc cagtcctgta tgtgcatcag acagcactct     1020

gcatggctta gagagcagct cccctctctc cccactgtca gccagttaca gttcacctct     1080

gtgggctgcg gagcacctct gccgcagccc agacatcttc cctgagcaga ggcagaacaa     1140

gcataggcgc tttcagaata ccctagccgt cctccggaag tctggtttgc tgggaatcac     1200

tctgaaagcc aaggagttga ttcgtcagaa ccaagcaact caggtggaac tggaccagct     1260

gaaggagcaa acccagatgt ttatagaggc caccaagagc agggctcctc aggcgtgggc     1320

caagttgcag gcgtcactca catctgggtc cagtcattca ggcagtgacc tagacacatt     1380

gtctgacccc ccagacatat agcacagaag catttccagt tgtttgagtt aactcctttg     1440

cgttcacaac tacacttgtt ttccacagcc tatttaagag cttttctttc taaagtcacc     1500

cacaaagcca cgtgccagtc cctggctgct gtcttaatct gtggcccatg cacaggttaa     1560

gtgtgttaag ttcgtgagga cctccagctg gaagtgtctg tgagtccctt tcccttagcc     1620

tgcacgcgct tagctggtcc ttgggacaag ggagagacgg ctgtgtctct tctagctgtt     1680

acttcccatc ctcctcctca ctgtccagga ccatggtgca gtgacatgga tgagtgcaca     1740

cagtgacact tgtccaacag ccaaggagta ggtgacctaa ggatcccttc actgtcctcc     1800

ttcaagtatg ttagtcatgg agaaaaagaa gaggatgtgt tttcatttta ccaggtgtgg     1860

tctgttgagt gaaacctaga atgctttggg ccaggtgcct gggggcaagc atttaccaca     1920

tgaggctttg ttccttacac ttgaaaggta agggagaaag ggcaaagcca tctgactcac     1980

accgatcaca cactgatctc acttatacca gtaggcaaat acttcagatt tttaaaatat     2040

agaatggatt taatactgtc tggaattgta tttgatgaat tgcttttttg atttaagggt     2100

caaagaaggc agcattttgg tcactagctg gaaggtttta gtaatttatg ctggaaatag     2160

cacaacccat cagaggcttg agatgggcct gtaggatggc tccgtgagta aaggtgctta     2220

ctgccaatga cctgagtctg acccctgaac cccatgatag accgagggaa cctactactg     2280

tacatgcaca tacaccatga taaatggata taaaattaaa aatagaagtc aacgtcaaaa     2340

caaggtaaaa caatcacaag cttgagatgg cttcagtggg tcctcggggt ctagtgtaag     2400

tccaccctca gctgtctctt gtctgtacct cacccagctg tgtctgaggg aaaaatgatc     2460

atgcttataa atttaagtta agtaaacccc aggccacagc aaccagaaaa catccatttt     2520

cacatctggg ttctcactca tgccctgtca tgatggggac actgtggaac agtcttgcac     2580

ctttgtttga tgtgggcagc agggctgaag tgtgatgtcc ctctctgagg ctggtcttag     2640

ggtggagagc ttaaggagat cccattgtct tcagcttccc tgtgtctaag tggtaaagat     2700

cccaaggctt gtatcctgcc tgttaaaatt ttcatcctcc tggaaatctt tgttctttac     2760

aaattaactt gggttttatg accagcctca tctttttctg cagagagtgt gctcttgggg     2820

ctttactagg tccagttaag gttcacattt attacatagc tggttgtaat tctaacatag     2880

tttaaaaagt ataagactca ggttggctcc actgtgctca taaagatata tgatttagat     2940

gcgactggtt taaaaatgat caacttggta aaatctctgt tctttggtca acatagaatt     3000

attacttgct gtttgctttc tgaaagtttc taaaatcaga gtcagtgttt ctgggtaggc     3060

tcgactcctt cccttgattc cgtggtattg tgttctgcac tccactggga agcatccttc     3120

ctggcagaat gtttggcagg aaggctgcag agacaggagc attcagagca gcctgcacca     3180

gctgtgcctt actgtgtgtc agaaggctgg gagcacttgc tgggagccaa gtatactact     3240

gcactggaaa agccctctgt ggtgctgtaa gtcatgggac tctcttccca cattcgggtt     3300

tcatttcctg tcctgtcccc ataagagatg atgagagcca ccgtggatcc tcactgctga     3360

gtggtgggag ggttggcccc gtcactgctc ctctgtgatc ctagaggcac agctgcacat     3420

ctctaggctg ctagcatagt gctctgttcc tggagcagct ggaagcagac agactccagt     3480

agagaatcct ttgaggcccg agagcagacc agcacttaga gaaagtctgg agtggaccag     3540

aagaatcttc attggttgcc caaggctgtg agtagcaatg gccttagtgc atgctatgag     3600

ctcttctgaa gcattatgta gggccgttgt tttctcaagg tgaggagtca attttaactc     3660

agaccagccc acaggagaac ccttgtcagt tgtattggca atatcggaca cagttagaaa     3720

ggttcccgac tgaaattggt tatagaatgc actgtcattt gtaatgtact acactgtttt     3780

tattgattat ggtactgtct gacctatctt ttctggtatg actccttcag cagacacatt     3840

gcttctgccc atatactgaa gcgactcctt agggtagaga ctaccaaatg tgagttcttc     3900

taagaaagtg tgaagtcatg tagaaattga ctgtgaaatg tcaaaaaaaa aaaaaataaa     3960

agtcatgtac ttgaaagcta                                                 3980


<210>  346
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Gln Arg Leu Pro Val Ile Gln Leu Pro Ala Leu Leu Asp Met Glu 
1               5                   10                  15      


Arg Lys Val Pro Ser Arg Glu Ser Pro Arg Arg Leu Ser Ala Lys Pro 
            20                  25                  30          


Gly Arg Gly Thr Glu Met Lys Lys Leu Ala Arg Pro Leu Gly Val Val 
        35                  40                  45              


Ala Ala Asp Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser Ser Glu 
    50                  55                  60                  


Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Val Val Ser Ala 
65                  70                  75                  80  


Leu Gly Trp Ser Arg Glu Asp Lys Leu Arg Gln Asn Ala Arg Ala Ala 
                85                  90                  95      


Asn His Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys Asn Val 
            100                 105                 110         


Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp Thr Val 
        115                 120                 125             


Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Phe Val Leu 
    130                 135                 140                 


His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly Glu Lys 
145                 150                 155                 160 


Lys Ser Glu Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr Thr Lys 
                165                 170                 175     


Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Ser Glu Glu Arg Gly 
            180                 185                 190         


Thr Ser Gly Ala Pro Lys Lys Ile Cys Val Glu Arg Leu Gly Pro Ser 
        195                 200                 205             


Leu Ser Ser Ser Glu Pro Ala Lys Pro Gly Arg Val Leu Ser Ser Pro 
    210                 215                 220                 


Phe Thr Pro Ala Leu Pro Ser Ser Lys Leu Thr Glu Asp Ser Ala Leu 
225                 230                 235                 240 


Gln Gly Val Pro Ser Leu Gly Ala Gly Gly Ser Pro Gln Thr Leu Gln 
                245                 250                 255     


Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser Leu Thr Phe Ala 
            260                 265                 270         


Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr Leu His Gly Leu 
        275                 280                 285             


Glu Ser Ser Ser Pro Leu Ser Pro Leu Ser Ala Ser Tyr Ser Ser Pro 
    290                 295                 300                 


Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp Ile Phe Pro Glu 
305                 310                 315                 320 


Gln Arg Gln Asn Lys His Arg Arg Phe Gln Asn Thr Leu Ala Val Leu 
                325                 330                 335     


Arg Lys Ser Gly Leu Leu Gly Ile Thr Leu Lys Ala Lys Glu Leu Ile 
            340                 345                 350         


Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln Leu Lys Glu Gln 
        355                 360                 365             


Thr Gln Met Phe Ile Glu Ala Thr Lys Ser Arg Ala Pro Gln Ala Trp 
    370                 375                 380                 


Ala Lys Leu Gln Ala Ser Leu Thr Ser Gly Ser Ser His Ser Gly Ser 
385                 390                 395                 400 


Asp Leu Asp Thr Leu Ser Asp Pro Pro Asp Ile 
                405                 410     


<210>  347
<211>  3508
<212>  DNA
<213>  Homo sapiens

<400>  347
gttttccagc cccgaaggag tcctttgggg ttggaggagg ggcgcgagcg cgcggcaaat       60

cgggcgggaa gaggtaaaaa aggaactggg agcgcgccgc ggcggttcct gtccttacag      120

ttgcgctgcc cagggaccga tgttgcgcga ggaaaatgcg ggacgcccag gtcggtgctc      180

ggcccagact tatgcccgtg ttttcacagc ccacactcgt gcccgaagcc ccttaccccg      240

ccccgggctg tggtctgtgg gctgtgggac gagctgcggc gcgggccatt tctgagcagt      300

ggaggtttca agtaatccac taacaaccag ttccaaattc tgtcatcaaa tcctgtgctg      360

ctgttcctcg tggtaataga tgcatattat ttcttttatt taaaagaaat gaatgtgact      420

agtattgcat taagagctga aacttggctt ttagctgcat ggcatgttaa agtacctccg      480

atgtggctgg aagcttgtat taactggatt caagaagaaa ataataatgt taacttgagt      540

caggcccaaa tgaataaaca agtgtttgag cagtggctcc ttactgatct gagggatttg      600

gagcatcctc ttttacccga tggcatttta gaaattccaa aaggagaatt aaatggattt      660

tatgctctgc agattaattc cttggttgat gtaagtcagc ctgcatactc ccagatacag      720

aagttgagag gaaagaatac aacaaatgat ctagttacag ctgaagcaca agtaacccca      780

aaaccttggg aagcaaagcc ttcacgaatg ttgatgctgc agctaactga tggaatcgta      840

caaatacagg gaatggaata tcagcctatt ccaattcttc atagtgatct tcctccaggt      900

acaaaaattt tgatttatgg aaatatatct ttccgtcttg gtgttctctt attgaaacca      960

gaaaacgtga aagtgttagg aggtgaagta gatgctcttt tagaagaata tgcccaagaa     1020

aaagtacttg caagattaat aggggaacct gatcttgtag tttcagtcat accaaacaat     1080

tctaacgaaa acattcccag agttacagat gttctagatc ctgcattagg tccttctgat     1140

gaagaactct tggcaagtct tgatgaaaat gatgagctta cagcaaataa tgacacttcc     1200

tcagaacgat gtttcaccac aggtagttcc tcaaatacca ttcccacaag acagtcaagt     1260

tttgagccag aatttgttat ttctccaaga ccaaaagagg aaccatcaaa cctatctata     1320

catgtaatgg atggagaatt agatgacttt tcactggagg aggccttgct tttagaagaa     1380

actgtccaga aagaacagat ggaaactaag gaattgcaac cattgacttt taacagaaat     1440

gccgatcgaa gtatagagag attttcacat aatcctaata ctacgaataa cttttctttg     1500

acttgcaaaa atggaaacaa taattggagt gaaaaaaatg tatctgaaca aatgactaat     1560

gaagacaaat catttggttg tccatctgtt agagaccaaa acaggagtat tttttcagtt     1620

cattgtaatg tacccttagc ccatgatttt acaaataaag aaaagaactt agagacagat     1680

aataaaataa aacaaaccag cagttcagat agccattcct taaataataa aatattaaat     1740

agagaggtgg tcaactatgt acagaaaagg aattcacaaa tttctaatga aaatgattgt     1800

aatttacaga gttgttcttt aagatcatca gagaatagca ttaatctttc tattgccatg     1860

gatttgtatt ctccaccctt tgtctatttg tctgttctaa tggccagcaa accaaaggaa     1920

gttacaacag tgaaagtgaa agcatttatt gtaaccttaa ctggaaatct ctcaagttct     1980

ggtggtattt ggagtataac tgcaaaggtg tctgatggta ctgcatatct agatgtagac     2040

tttgtggatg aaatacttac tagcttgata gggttctcag taccagaaat gaaacagtca     2100

aaaaaggatc ctcttcaata ccaaaagttc ctggaagggt tgcagaaatg tcaaagagat     2160

ctaatagatt tgtgctgtct aatgactatt tcatttaatc cttccttgtc taaagcaatg     2220

gtactggcat tacaagatgt taatatggaa caccttgaga atctaaagaa gcggttaaat     2280

aaataattaa actaaaatag tattaggaac aattaaaaac aacaaggaaa tatttagaat     2340

ttgttcacaa ttttacttat gatactttgt gtaaaaagga aaaatgaaat ttcatagctt     2400

atttcagttt aattttaaag tgtttaatca tgtttgttat atgtggagct tttgaaaata     2460

agttaatctt tttttttttt tttttaatgt cagggtattg ctctgttgcc caggctagag     2520

tgcagtggca tgatcatagg ttattgcatc aacctcttga gctcaagcga tcctcctgcc     2580

ttagcctctt gagttgctgg gactataggc atgtaccacc atgcccagct aatttataat     2640

tactattatt gttttgtagg gacagagttt tgctatgttg cccagattgg tctcaaactc     2700

ctggcctctc actcctgccg tcatggcctc caaagtttac tttttttaaa agtaactgtt     2760

agatggagga atatggtgac ccactattgt tgagaaattt gttttccact tgtcacgtca     2820

cataagatga ttgctaaaat attgtactgg tgttcggtgg tgagtcatat ttttgaaagt     2880

taataattat aaataggtaa tttccttcta atatgttggt actgtctatg gccataccac     2940

cctgaacatg cctgagcttg tcataatatg ttgagtaccc aaaagatttg tttatattgt     3000

taatcttagg gaaaaaaaat taaaatccag tagatcagaa catcaggctt tcagatacaa     3060

attgatttac tggtttttat tttgctgatt ataatatttg gtatatttaa ggtaatctag     3120

ttaactagat gctatttcat agattatatt gaatgattta aaactttatt ttcaaggata     3180

gtttatttta aatggcatat tgaaaacatc attattaaga tccagtaggt aggacattta     3240

ttggattaaa atgaagcatt tatctatgtc tttaggtgtc attgttccct ttctgaatta     3300

gctgtacata taagccttcc tttggtttta agtactgatt tttttttaaa aaaaagaggg     3360

actgtttacc attcttccac tgtgctgtta taaagttgta tttgaaaggt aatgttgttt     3420

ttattaatct tttgtcttaa aataatttaa agtgctttga attttaaaac attaaacaaa     3480

tccttaaata acaaaaaaaa aaaaaaaa                                        3508


<210>  348
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Asn Val Thr Ser Ile Ala Leu Arg Ala Glu Thr Trp Leu Leu Ala 
1               5                   10                  15      


Ala Trp His Val Lys Val Pro Pro Met Trp Leu Glu Ala Cys Ile Asn 
            20                  25                  30          


Trp Ile Gln Glu Glu Asn Asn Asn Val Asn Leu Ser Gln Ala Gln Met 
        35                  40                  45              


Asn Lys Gln Val Phe Glu Gln Trp Leu Leu Thr Asp Leu Arg Asp Leu 
    50                  55                  60                  


Glu His Pro Leu Leu Pro Asp Gly Ile Leu Glu Ile Pro Lys Gly Glu 
65                  70                  75                  80  


Leu Asn Gly Phe Tyr Ala Leu Gln Ile Asn Ser Leu Val Asp Val Ser 
                85                  90                  95      


Gln Pro Ala Tyr Ser Gln Ile Gln Lys Leu Arg Gly Lys Asn Thr Thr 
            100                 105                 110         


Asn Asp Leu Val Thr Ala Glu Ala Gln Val Thr Pro Lys Pro Trp Glu 
        115                 120                 125             


Ala Lys Pro Ser Arg Met Leu Met Leu Gln Leu Thr Asp Gly Ile Val 
    130                 135                 140                 


Gln Ile Gln Gly Met Glu Tyr Gln Pro Ile Pro Ile Leu His Ser Asp 
145                 150                 155                 160 


Leu Pro Pro Gly Thr Lys Ile Leu Ile Tyr Gly Asn Ile Ser Phe Arg 
                165                 170                 175     


Leu Gly Val Leu Leu Leu Lys Pro Glu Asn Val Lys Val Leu Gly Gly 
            180                 185                 190         


Glu Val Asp Ala Leu Leu Glu Glu Tyr Ala Gln Glu Lys Val Leu Ala 
        195                 200                 205             


Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn 
    210                 215                 220                 


Ser Asn Glu Asn Ile Pro Arg Val Thr Asp Val Leu Asp Pro Ala Leu 
225                 230                 235                 240 


Gly Pro Ser Asp Glu Glu Leu Leu Ala Ser Leu Asp Glu Asn Asp Glu 
                245                 250                 255     


Leu Thr Ala Asn Asn Asp Thr Ser Ser Glu Arg Cys Phe Thr Thr Gly 
            260                 265                 270         


Ser Ser Ser Asn Thr Ile Pro Thr Arg Gln Ser Ser Phe Glu Pro Glu 
        275                 280                 285             


Phe Val Ile Ser Pro Arg Pro Lys Glu Glu Pro Ser Asn Leu Ser Ile 
    290                 295                 300                 


His Val Met Asp Gly Glu Leu Asp Asp Phe Ser Leu Glu Glu Ala Leu 
305                 310                 315                 320 


Leu Leu Glu Glu Thr Val Gln Lys Glu Gln Met Glu Thr Lys Glu Leu 
                325                 330                 335     


Gln Pro Leu Thr Phe Asn Arg Asn Ala Asp Arg Ser Ile Glu Arg Phe 
            340                 345                 350         


Ser His Asn Pro Asn Thr Thr Asn Asn Phe Ser Leu Thr Cys Lys Asn 
        355                 360                 365             


Gly Asn Asn Asn Trp Ser Glu Lys Asn Val Ser Glu Gln Met Thr Asn 
    370                 375                 380                 


Glu Asp Lys Ser Phe Gly Cys Pro Ser Val Arg Asp Gln Asn Arg Ser 
385                 390                 395                 400 


Ile Phe Ser Val His Cys Asn Val Pro Leu Ala His Asp Phe Thr Asn 
                405                 410                 415     


Lys Glu Lys Asn Leu Glu Thr Asp Asn Lys Ile Lys Gln Thr Ser Ser 
            420                 425                 430         


Ser Asp Ser His Ser Leu Asn Asn Lys Ile Leu Asn Arg Glu Val Val 
        435                 440                 445             


Asn Tyr Val Gln Lys Arg Asn Ser Gln Ile Ser Asn Glu Asn Asp Cys 
    450                 455                 460                 


Asn Leu Gln Ser Cys Ser Leu Arg Ser Ser Glu Asn Ser Ile Asn Leu 
465                 470                 475                 480 


Ser Ile Ala Met Asp Leu Tyr Ser Pro Pro Phe Val Tyr Leu Ser Val 
                485                 490                 495     


Leu Met Ala Ser Lys Pro Lys Glu Val Thr Thr Val Lys Val Lys Ala 
            500                 505                 510         


Phe Ile Val Thr Leu Thr Gly Asn Leu Ser Ser Ser Gly Gly Ile Trp 
        515                 520                 525             


Ser Ile Thr Ala Lys Val Ser Asp Gly Thr Ala Tyr Leu Asp Val Asp 
    530                 535                 540                 


Phe Val Asp Glu Ile Leu Thr Ser Leu Ile Gly Phe Ser Val Pro Glu 
545                 550                 555                 560 


Met Lys Gln Ser Lys Lys Asp Pro Leu Gln Tyr Gln Lys Phe Leu Glu 
                565                 570                 575     


Gly Leu Gln Lys Cys Gln Arg Asp Leu Ile Asp Leu Cys Cys Leu Met 
            580                 585                 590         


Thr Ile Ser Phe Asn Pro Ser Leu Ser Lys Ala Met Val Leu Ala Leu 
        595                 600                 605             


Gln Asp Val Asn Met Glu His Leu Glu Asn Leu Lys Lys Arg Leu Asn 
    610                 615                 620                 


Lys 
625 


<210>  349
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  349
ggggtgatga aggcctgcac ctggtcccct ccccaactct gctctgctcc tgaag            55


<210>  350
<211>  616
<212>  DNA
<213>  Homo sapiens

<400>  350
cttccttttg cgggtggcgg cgaacgcgga gagcacgcca tgaaggcctc gggcacgcta       60

cgagagtaca aggtagtggg tcgctgcctg cccaccccca aatgccacac gccgcccctc      120

taccgcatgc gaatctttgc gcctaatcat gtcgtcgcca agtcccgctt ctggtacttt      180

gtatctcagt taaagaagat gaagaagtct tcaggggaga ttgtctactg tgggcaggtg      240

tttgagaagt cccccctgcg ggtgaagaac ttcaggatct ggctgcgcta tgactcccgg      300

agcggcaccc acaacatgta ccgggaatac cgggacctga ccaccgcagg cgctgtcacc      360

cagtgctacc gagacatggg tgcccggcac cgcgcccgag cccactccat tcagatcatg      420

aaggtggagg agatcgcggc cagcaagtgc cgccggccgg ctgtcaagca gttccacgac      480

tccaagatca agttcccgct gccccaccgg gtcctgcgcc gtcagcacaa gccacgcttc      540

accaccaaga ggcccaacac cttcttctag gtgcagggcc ctcgtccggg tgtgccccaa      600

ataaactcag gaacgc                                                      616


<210>  351
<211>  4906
<212>  DNA
<213>  Homo sapiens

<400>  351
aacgaggccc ttagggtcgg cttaggcggt tccctgacca aggcgccaga aaagggcctg       60

gctcaagcaa gcacgggcgg cgtgcagtac agcacaccta gccccgattc ttcaacagtt      120

ctcgccctcc gagcctagca caacgagcct caccgaaacc gtacaccgcc accaggacac      180

tccgtgatgg gggatcacca ccctcagaaa gaggaagcga ctagcaggcg cgcaatcccg      240

cgagaccagg aggccccgcc cgaagcccgg cctctgtgac cggaagtgag gcgttttgcc      300

ccgcccccgt ggccgatacc tcgcgagact tggcgaaggc cttccttttt cgtctgggct      360

gccaacatgc catccagact gaggaagacc cggaaactta ggggccacgt gagccacggc      420

cacggccgca taggcaagca ccggaagcac cccggcggcc gcggtaatgc tggtggtctg      480

catcaccacc ggatcaactt cgacaaatac cacccaggct actttgggaa agttggtatg      540

aagcattacc acttaaagag gaaccagagc ttctgcccaa ctgtcaacct tgacaaattg      600

tggactttgg tcagtgaaca gacacgggtg aatgctgcta aaaacaagac tggggctgct      660

cccatcattg atgtggtgcg atcgggctac tacaaagttc tgggaaaggg aaagctccca      720

aagcagcctg tcatcgtgaa ggccaaattc ttcagcagaa gagctgagga gaagattaag      780

agtgttgggg gggcctgtgt cctggtggct tgaagccaca tggagggagt ttcattaaat      840

gctaactact ttttccttgt ggtgtgagtg taggttcttc agtggcacct ctacatcctg      900

tgtgcattgg gagcccaggt tctagtactt agggtatgaa gacatggggt cctctcctga      960

cttccctcaa atatatggta aacgtaagac caacacagac gttggccagt taaacatttc     1020

tgtttataaa gtcagaataa tacctgttga tcactgaaag gcctgcatgt attgtactct     1080

gaattttaca gtgaatgaga gaatgtaccc taattgttca acagggctca aaaggaaaga     1140

ttccattttg atgggtcaca ttctaaagag gggcagtgtg ataggaatga gatggtcctt     1200

taggacttaa gttctcagcc caaggttttt ccacgtggcc ccctcatctt tttttttttt     1260

ttaaacggag tctctcttgc caggctggag tgcagtggca cgatctcggc tcactgcagc     1320

ctccgcctcc caggttaagc gattctcctg cctcagcttc ctgactaact gggattacag     1380

gcgcccacca ccatgcccag ctaatttttg tattttcagt agagatgggg tttcaccatg     1440

ttggccatgc tggtctctaa ctcctaacct caagtgatct gcccacatcg gcctccaaaa     1500

gttctgggat tatagtgtga gccactgcgc ccggccatgg ctccttaatc ttgatccaaa     1560

ttattgttac atccagaatg tgatgaatca aaatctcgag atgggggtcc agcaatctga     1620

aatttcagta tgccagggct tttctgtatg tcaaagtggg tttgaaatag ttaatttttc     1680

ttctagtctg aaatgtatcg ggaaaatttg gaaatcctga aggctggaaa ttgaaataag     1740

tttttctagg atttgtgtct cttgctattg gaaaactgat ggtgaccaat tcatgtttac     1800

aaataagatc ctcatagatc tcggtaaatt ataatttgct acagttttat ggttcttcct     1860

gtgattttga gctttttttg acccaaaata atacagtcta aaactataga caaataagat     1920

ggcacttaga ctcctgggtt ttagttagtg gaggtttcct tagtgcactg tggggtcata     1980

ataagccgag aaccatggct gtctatggga cacatctgtc aggacaacct ttagaggatg     2040

ttggggatca aatagaaggc acagagaagc actgaattgg cttacataag aataggctag     2100

aattacaagt agtgaaacct cgattcagct ggacaatttt aaacaaatgt atcatttggc     2160

ttgtatcttc tgttgtgctg gagaagttag aaataagggc tctccagacc agcctgacca     2220

acctggagaa accttgtctc tactaaatac acaaaattag ccaggcgtgg tggcacatgc     2280

ctgtaatccc agctactttg gaggctgagc caggagaatc tccaggaggc ggaggttgct     2340

gtgagccgag atcgtgccat tgcactccag cttgggcaac aagagtgaaa ctctgtccac     2400

cccccccaaa aaaagtaagg gctctccatt agggcccata gaggacttgt aatatggaac     2460

ctgaatccaa ggatcccaca ataagtggtc agtagttcat gatgaattaa aagactcaat     2520

atttggtctt cacccaatac ctgtgtgact tttagtccta atttcctcat ctttaaaatt     2580

tcagtgaaag tgcctacctg aggattgtgt agattaaaat ggaaaccgtg cacttaattt     2640

tttgttttgt tttgagacgg agtctcgctc tgtcgcccag gctggagtgc agtggtgcga     2700

tctcagatca ctgcaagctc cgcctcctag gttcagacca ttctcctgcc tcagcttccc     2760

aagtagctgg gactacaggc gcccgccact gcgcccggct aattttttgc atttttagta     2820

gagacagggt ttcaccgtgt tagccaggat ggtctcgatc tcctgatctg cccgcctcag     2880

cctcccaaag tgctgggatt acaggcatga gccaccgcgc ccggcccagg cacttaattt     2940

ttgtgtttga cttagtaact taagtgcaaa ctattacggg agcagatgga gtcaattggc     3000

cttcatgtga ttgtcagtgg gaaattggtc caagcagagg gaatactggt tcaggaaact     3060

ggtttgggaa ggttaggcaa acgggaagtg ctatggtgga gagaaagatt actctggccg     3120

ggctgtaaag gacggctaca atgggaggct gaaggcagaa ccaagaaaat gggagtgagt     3180

atggaaaagg tacgattcag acggcataat ggacgggact tggagactga attgtagtgg     3240

gccgaccaca aaatgataag gcatggaagg aagtagagtt tggggggaag gatccctagt     3300

cccttaatgg ctaccttctt ccccaggagt tgttaggcca tccgatcccc tggcctggga     3360

aagaaacact gatttcgttg ctggcttgtt cactcaccag aagctacagc tactaacagt     3420

tctaaaaact gtttcatgtg atgaggaaca gacgaaaata gttttgagcc ctaagtccgc     3480

cgattccagt gctttcttga acccgcattt actaaaatat tttcatgact gccaagcttt     3540

gaatagcctg ctgtgttcat ggaggctcat actggcgatc tctagtggct ggctaaagct     3600

tgaattgcaa aagatctaat ttctggtcta atgtatatat gccttaaata tagttgcgtt     3660

caaacgtggg agctgcaggt gcaacttgat tttatgacaa atggctgcca cataatttgc     3720

acaagcagtg ctcgtcaagg gcagctaaat caggcgagct ttcaatcaaa ataaatgtac     3780

tactaaaccc tacttagcgg ctaactagcc caagagcaga cagcccacgg acggactgca     3840

agtcggaagc gcgggcggaa gctgtgcagc gcccacctgg tggctccatc ggccgcgttc     3900

atcagtcagc acgacccgac ctcagtggcg tcctcacaac acagaccgga ccttgggtct     3960

taccccggca cctgagaacc acttccggtg agtagcttct acttccggag acgatgactc     4020

ccccgcgtcc cagaccggaa gaagcccggc ggagaccggc ctcgctcggc cacttccggc     4080

aagggcggag ccggccagtg gtgcgcgagc gcagataact cccctggaga ggcgggatgt     4140

tcaactccac ccctggtcct tgggcggccg tgggtcccct tcgaagcgga ggaatggcca     4200

acctcgccgc acttcgagcc cctttagggt gcgtttaaga acagtgggcg tggcctttac     4260

gtaaatcttc gagatgggaa cctccagaat ttgtctcaat tgtctaaaag gtaatgagcg     4320

tcagcgacat tcaagggcac tttgggctaa aaaagaaagt gcttgtacac ggatggaaat     4380

attctagaag aacataaaag gaatttcctc ttaggaggtt agggaaatga gcacgaagta     4440

tgttttggtg cagttttttg ttcaacccaa tgcgtatttt catattgaga ggcaatataa     4500

atggagcgaa agtatcttga gaaaaaaaaa aaaactacca gaacttgccg ttgctgaaaa     4560

gtaatatttt ctctttcgag agttttcatg gccttttaaa ttacaccccc acctccacag     4620

gcaaataaat ttgttttgga atgcatacca catcatctgg ctctagaaac gtattttgtg     4680

tagctcccct agcaagaata taggttaaag cgtaaattta attcctggct ctattttaca     4740

tcccaatttt tattttcctc tcattcccac tttacgttgt ttcaaataac ctagtttgtg     4800

tatccctgta agtcattttg gtataaagta ggttataagt gtacatgcga aaagatgttt     4860

ttaacaaaaa tgtaactgaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    4906


<210>  352
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Pro Ser Arg Leu Arg Lys Thr Arg Lys Leu Arg Gly His Val Ser 
1               5                   10                  15      


His Gly His Gly Arg Ile Gly Lys His Arg Lys His Pro Gly Gly Arg 
            20                  25                  30          


Gly Asn Ala Gly Gly Leu His His His Arg Ile Asn Phe Asp Lys Tyr 
        35                  40                  45              


His Pro Gly Tyr Phe Gly Lys Val Gly Met Lys His Tyr His Leu Lys 
    50                  55                  60                  


Arg Asn Gln Ser Phe Cys Pro Thr Val Asn Leu Asp Lys Leu Trp Thr 
65                  70                  75                  80  


Leu Val Ser Glu Gln Thr Arg Val Asn Ala Ala Lys Asn Lys Thr Gly 
                85                  90                  95      


Ala Ala Pro Ile Ile Asp Val Val Arg Ser Gly Tyr Tyr Lys Val Leu 
            100                 105                 110         


Gly Lys Gly Lys Leu Pro Lys Gln Pro Val Ile Val Lys Ala Lys Phe 
        115                 120                 125             


Phe Ser Arg Arg Ala Glu Glu Lys Ile Lys Ser Val Gly Gly Ala Cys 
    130                 135                 140                 


Val Leu Val Ala 
145             


<210>  353
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  353
ggaagttata ctagaatagg cagcccaggc ttccggttct aggtgcttca ggagccgtgg       60

cttaaggtgc agacatggcc aagtccacac catacaccac cagtcccgaa aatggcacag      120

aaatggtatc aagaaaccgc gatcacaaag atacaaatct cttaaggggg tggactccaa      180

gttcctgagg aacatgcgct ttgccaagaa gcacaaaaga agggcctaaa gaagatgcac      240

accaacaatg ccaaggccat gagtccacgt gccgaggctc tcaaggccct cgtaaagccc      300

aaggaggtta agcccaagat cccaaagggt gtcagccata aacttgatcg acttgcctac      360

attgcccacc ccaaccttgg gaagcttgct cgtgcccgca tggccaaggg gctcaggctg      420

tgccggccca aggccaaggc caaggatcaa accaaggccc aggctgcagc tccagcttca      480

gtttcagctc aggctcccaa agctgcccag tgccctacaa agacttcaga gtagatatct      540

ctgtctgcca acgtgaggac agaaggacag gtgccaccca ccccgggctg ccgtctgcat      600

ggggctgggg tcctcctgcg ctattggtac aaataagcct gaggcagaaa aaaaaaa         657


<210>  354
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  354
atggccaagt ccaagaacca cagcacaaac aaccagtccc gaaaaaggca cagaaatggt       60

atcaagaaac cccgatcacg aagatatgaa tctcttaagg ggatggaccc caagttcccg      120

aggaacatgt gctttgccaa gaagcaaaac aagaaggtcc taaagaagat gcaggccaac      180

agtgacaagg ccatgagtgc acgtgctgag gttatcaagg ccctcgtaaa gcccaaggag      240

gttaagctca agatcccaaa gggtgtcagc tgcaagctcg atcgacttgc ctacattgcc      300

caccccaagc ttgggaagcg ggctcgtgcc cgcattgcca aggggctcag gctgtgctgg      360

ccaaaggcca aggccaagga tcaaaccaag gcccaggctg cagctccagc ttcagttcca      420

gctcaggctc ccaaaggtgc ccaggcccct acaaaggctt cagagtag                   468


<210>  355
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Ala Lys Ser Lys Asn His Ser Thr Asn Asn Gln Ser Arg Lys Arg 
1               5                   10                  15      


His Arg Asn Gly Ile Lys Lys Pro Arg Ser Arg Arg Tyr Glu Ser Leu 
            20                  25                  30          


Lys Gly Met Asp Pro Lys Phe Pro Arg Asn Met Cys Phe Ala Lys Lys 
        35                  40                  45              


Gln Asn Lys Lys Val Leu Lys Lys Met Gln Ala Asn Ser Asp Lys Ala 
    50                  55                  60                  


Met Ser Ala Arg Ala Glu Val Ile Lys Ala Leu Val Lys Pro Lys Glu 
65                  70                  75                  80  


Val Lys Leu Lys Ile Pro Lys Gly Val Ser Cys Lys Leu Asp Arg Leu 
                85                  90                  95      


Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 
            100                 105                 110         


Ala Lys Gly Leu Arg Leu Cys Trp Pro Lys Ala Lys Ala Lys Asp Gln 
        115                 120                 125             


Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro Ala Gln Ala Pro 
    130                 135                 140                 


Lys Gly Ala Gln Ala Pro Thr Lys Ala Ser Glu 
145                 150                 155 


<210>  356
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  356
atggccaagt ccaagaacca cagcacaaac aaccagtccc gaaaaaggca cagaaatggt       60

atcaagaaac cccgatcacg aagatatgaa tctcttaagg ggatggaccc caagttcccg      120

aggaacatgt gctttgccaa gaagcaaaac aagaaggtcc taaagaagat gcaggccaac      180

agtgacaagg ccatgagtgc acgtgctgag gttatcaagg ccctcgtaaa gcccaaggag      240

gttaagctca agatcccaaa gggtgtcagc tgcaagctcg atcgacttgc ctacattgcc      300

caccccaagc ttgggaagcg ggctcgtgcc cgcattgcca aggggctcag gctgtgctgg      360

ccaaaggcca aggccaagga tcaaaccaag gcccaggctg cagctccagc ttcagttcca      420

gctcaggctc ccaaaggtgc ccaggcccct acaaaggctt cagagtag                   468


<210>  357
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Ala Lys Ser Lys Asn His Ser Thr Asn Asn Gln Ser Arg Lys Arg 
1               5                   10                  15      


His Arg Asn Gly Ile Lys Lys Pro Arg Ser Arg Arg Tyr Glu Ser Leu 
            20                  25                  30          


Lys Gly Met Asp Pro Lys Phe Pro Arg Asn Met Cys Phe Ala Lys Lys 
        35                  40                  45              


Gln Asn Lys Lys Val Leu Lys Lys Met Gln Ala Asn Ser Asp Lys Ala 
    50                  55                  60                  


Met Ser Ala Arg Ala Glu Val Ile Lys Ala Leu Val Lys Pro Lys Glu 
65                  70                  75                  80  


Val Lys Leu Lys Ile Pro Lys Gly Val Ser Cys Lys Leu Asp Arg Leu 
                85                  90                  95      


Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 
            100                 105                 110         


Ala Lys Gly Leu Arg Leu Cys Trp Pro Lys Ala Lys Ala Lys Asp Gln 
        115                 120                 125             


Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro Ala Gln Ala Pro 
    130                 135                 140                 


Lys Gly Ala Gln Ala Pro Thr Lys Ala Ser Glu 
145                 150                 155 


<210>  358
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  358
atggccaagt ccaagaacca cagcacaaac aaccagtccc gaaaaaggca cagaaatggt       60

atcaagaaac cccgatcacg aagatatgaa tctcttaagg ggatggaccc caagttcccg      120

aggaacatgt gctttgccaa gaagcaaaac aagaaggtcc taaagaagat gcaggccaac      180

agtgacaagg ccatgagtgc acgtgctgag gttatcaagg ccctcgtaaa gcccaaggag      240

gttaagctca agatcccaaa gggtgtcagc tgcaagctcg atcgacttgc ctacattgcc      300

caccccaagc ttgggaagcg ggctcgtgcc cgcattgcca aggggctcag gctgtgctgg      360

ccaaaggcca aggccaagga tcaaaccaag gcccaggctg cagctccagc ttcagttcca      420

gctcaggctc ccaaaggtgc ccaggcccct acaaaggctt cagagtag                   468


<210>  359
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Ala Lys Ser Lys Asn His Ser Thr Asn Asn Gln Ser Arg Lys Arg 
1               5                   10                  15      


His Arg Asn Gly Ile Lys Lys Pro Arg Ser Arg Arg Tyr Glu Ser Leu 
            20                  25                  30          


Lys Gly Met Asp Pro Lys Phe Pro Arg Asn Met Cys Phe Ala Lys Lys 
        35                  40                  45              


Gln Asn Lys Lys Val Leu Lys Lys Met Gln Ala Asn Ser Asp Lys Ala 
    50                  55                  60                  


Met Ser Ala Arg Ala Glu Val Ile Lys Ala Leu Val Lys Pro Lys Glu 
65                  70                  75                  80  


Val Lys Leu Lys Ile Pro Lys Gly Val Ser Cys Lys Leu Asp Arg Leu 
                85                  90                  95      


Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 
            100                 105                 110         


Ala Lys Gly Leu Arg Leu Cys Trp Pro Lys Ala Lys Ala Lys Asp Gln 
        115                 120                 125             


Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro Ala Gln Ala Pro 
    130                 135                 140                 


Lys Gly Ala Gln Ala Pro Thr Lys Ala Ser Glu 
145                 150                 155 


<210>  360
<211>  1348
<212>  DNA
<213>  Homo sapiens

<400>  360
ccagatttgg ctttatatag cggacccgta aggccgaccg gcctctaccg gcgggatttg       60

atggcgtgat gtctcacaga aagttctccg ctcccagaca tgggtccctc ggcttcctgc      120

ctcggaagcg cagcagcagg catcgtggga aggtgaagag cttccctaag gatgacccgt      180

ccaagccggt ccacctcaca gccttcctgg gatacaaggc tggcatgact cacatcgtgc      240

gggaagtcga caggccggga tccaaggtga acaagaagga ggtggtggag gctgtgacca      300

ttgtagagac accacccatg gtggttgtgg gcattgtggg ctacgtggaa acccctcgag      360

gcctccggac cttcaagact gtctttgctg agcacatcag tgatgaatgc aagaggcgtt      420

tctataagaa ttggcataaa tctaagaaga aggcctttac caagtactgc aagaaatggc      480

aggatgagga tggcaagaag cagctggaga aggacttcag cagcatgaag aagtactgcc      540

aagtcatccg tgtcattgcc cacacccaga tgcgcctgct tcctctgcgc cagaagaagg      600

cccacctgat ggagatccag gtgaacggag gcactgtggc cgagaagctg gactgggccc      660

gcgagaggct tgagcagcag gtacctgtga accaagtgtt tgggcaggat gagatgatcg      720

acgtcatcgg ggtgaccaag ggcaaaggct acaaaggggt caccagtcgt tggcacacca      780

agaagctgcc ccgcaagacc caccgaggcc tgcgcaaggt ggcctgtatt ggggcatggc      840

atcctgctcg tgtagccttc tctgtggcac gcgctgggca gaaaggctac catcaccgca      900

ctgagatcaa caagaagatt tataagattg gccagggcta ccttatcaag gacggcaagc      960

tgatcaagaa caatgcctcc actgactatg acctatctga caagagcatc aaccctctgg     1020

gtggctttgt ccactatggt gaagtgacca atgactttgt catgctgaaa ggctgtgtgg     1080

tgggaaccaa gaagcgggtg ctcaccctcc gcaagtcctt gctggtgcag acgaagcggc     1140

gggctctgga gaagattgac cttaagttca ttgacaccac ctccaagttt ggccatggcc     1200

gcttccagac catggaggag aagaaagcat tcatgggacc actgaagaaa gaccgaattg     1260

caaaggaaga aggagcttaa tgccaggaac agattttgca gttggtgggg tctcaataaa     1320

agttattttc cactgacaaa aaaaaaaa                                        1348


<210>  361
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15      


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30          


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60                  


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110         


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Glu Asp Gly Lys Lys 
    130                 135                 140                 


Gln Leu Glu Lys Asp Phe Ser Ser Met Lys Lys Tyr Cys Gln Val Ile 
145                 150                 155                 160 


Arg Val Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys 
                165                 170                 175     


Lys Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190         


Lys Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn 
        195                 200                 205             


Gln Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys 
    210                 215                 220                 


Gly Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240 


Pro Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255     


Trp His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys 
            260                 265                 270         


Gly Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly 
        275                 280                 285             


Gln Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser 
    290                 295                 300                 


Thr Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe 
305                 310                 315                 320 


Val His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys 
                325                 330                 335     


Val Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350         


Val Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile 
        355                 360                 365             


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu 
    370                 375                 380                 


Lys Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Ala 
            


<210>  362
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  362
ccagatttgg ctttatatag cggacccgta aggccgaccg gcctctaccg gcgggatttg       60

atggcgtgat gtctcacaga aagttctccg ctcccagaca tgggtccctc ggcttcctgc      120

ctcggaagcg cagcagcagg catcgtggga aggtgaagag cttccctaag gatgacccgt      180

ccaagccggt ccacctcaca gccttcctgg gatacaaggc tggcatgact cacatcgtgc      240

gggaagtcga caggccggga tccaaggtga acaagaagga ggtggtggag gctgtgacca      300

ttgtagagac accacccatg gtggttgtgg gcattgtggg ctacgtggaa acccctcgag      360

gcctccggac cttcaagact gtctttgctg agcacatcag tgatgaatgc aagaggcgtt      420

tctataagaa ttggcataaa tctaagaaga aggcccacct gatggagatc caggtgaacg      480

gaggcactgt ggccgagaag ctggactggg cccgcgagag gcttgagcag caggtacctg      540

tgaaccaagt gtttgggcag gatgagatga tcgacgtcat cggggtgacc aagggcaaag      600

gctacaaagg ggtcaccagt cgttggcaca ccaagaagct gccccgcaag acccaccgag      660

gcctgcgcaa ggtggcctgt attggggcat ggcatcctgc tcgtgtagcc ttctctgtgg      720

cacgcgctgg gcagaaaggc taccatcacc gcactgagat caacaagaag atttataaga      780

ttggccaggg ctaccttatc aaggacggca agctgatcaa gaacaatgcc tccactgact      840

atgacctatc tgacaagagc atcaaccctc tgggtggctt tgtccactat ggtgaagtga      900

ccaatgactt tgtcatgctg aaaggctgtg tggtgggaac caagaagcgg gtgctcaccc      960

tccgcaagtc cttgctggtg cagacgaagc ggcgggctct ggagaagatt gaccttaagt     1020

tcattgacac cacctccaag tttggccatg gccgcttcca gaccatggag gagaagaaag     1080

cattcatggg accactgaag aaagaccgaa ttgcaaagga agaaggagct taatgccagg     1140

aacagatttt gcagttggtg gggtctcaat aaaagttatt ttccactgac aaaaaaaaaa     1200

a                                                                     1201


<210>  363
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15      


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30          


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60                  


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110         


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu Lys 
    130                 135                 140                 


Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn Gln 
145                 150                 155                 160 


Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys Gly 
                165                 170                 175     


Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu Pro 
            180                 185                 190         


Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala Trp 
        195                 200                 205             


His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys Gly 
    210                 215                 220                 


Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly Gln 
225                 230                 235                 240 


Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser Thr 
                245                 250                 255     


Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe Val 
            260                 265                 270         


His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys Val 
        275                 280                 285             


Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu Val 
    290                 295                 300                 


Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile Asp 
305                 310                 315                 320 


Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu Lys 
                325                 330                 335     


Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu Glu 
            340                 345                 350         


Gly Ala 
        


<210>  364
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  364
cttttttctt cctcttccgg ggacgttgtc tgcaggcact cagaatggtc cagcgtttga       60

cataccgacg taggctttcc tacaatacag cctctaacaa aactaggctg tcccgaaccc      120

ctggtaatag aattgtttac ctttatacca agaaggttgg gaaagcacca aaatctgcat      180

gtggtgtgtg cccaggcaga cttcgagggg ttcgtgctgt aagacctaaa gttcttatga      240

gattgtccaa aacaaagaaa catgtcagca gggcctatgg tggttccatg tgtgctaaat      300

gtgttcgtga caggatcaag cgtgctttcc ttatcgagga gcagaaaatc gttgtgaaag      360

tgttgaaggc acaagcacag agtcagaaag ctaaataaaa aaatgaaact tttttgagta      420

ataaaaatga aaagacgctg tccaatagaa aaagttggtg tgctggagct acctcacctc      480

agcttgagag agccagttgt gtgcatctct ttccagtttt gcatccagtg acgtctgctt      540

ggcatcttga gattgttatg gtgagagtat ttacacctca gcaaatgctg caaaatcctg      600

ttttccccca gagagctgga ggttaaatac taccagcaca tccctagata ctactcaagt      660

tacagtatat gatcactaat atagtatgct cttggtacca ggagctctga tatatatctg      720

gtacatgttt gataatgact tgattgttat tataagtact tattaatact tcgattctgt      780

aaagagttta gggtttgatt ttataaaatc caaaatgagc cttttattga atccagttct      840

ctatgtgacc agttctctgt atgaatggaa gggaaaagaa ttaaaaatct tgcaaagggg      900

aaaaaaaaaa aaaaaaaa                                                    918


<210>  365
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210>  366
<211>  1003
<212>  DNA
<213>  Homo sapiens

<400>  366
gtctgcaggt atggatgttg ttctcttttc cctgtcttta tttccttacc aatcggctgc       60

catccgagga gctgaggaag cctagagctc tcagaagcag tcctttgagc tggtgtaggg      120

gcactcagaa tggtccagcg tttgacatac cgacgtaggc tttcctacaa tacagcctct      180

aacaaaacta ggctgtcccg aacccctggt aatagaattg tttaccttta taccaagaag      240

gttgggaaag caccaaaatc tgcatgtggt gtgtgcccag gcagacttcg aggggttcgt      300

gctgtaagac ctaaagttct tatgagattg tccaaaacaa agaaacatgt cagcagggcc      360

tatggtggtt ccatgtgtgc taaatgtgtt cgtgacagga tcaagcgtgc tttccttatc      420

gaggagcaga aaatcgttgt gaaagtgttg aaggcacaag cacagagtca gaaagctaaa      480

taaaaaaatg aaactttttt gagtaataaa aatgaaaaga cgctgtccaa tagaaaaagt      540

tggtgtgctg gagctacctc acctcagctt gagagagcca gttgtgtgca tctctttcca      600

gttttgcatc cagtgacgtc tgcttggcat cttgagattg ttatggtgag agtatttaca      660

cctcagcaaa tgctgcaaaa tcctgttttc ccccagagag ctggaggtta aatactacca      720

gcacatccct agatactact caagttacag tatatgatca ctaatatagt atgctcttgg      780

taccaggagc tctgatatat atctggtaca tgtttgataa tgacttgatt gttattataa      840

gtacttatta atacttcgat tctgtaaaga gtttagggtt tgattttata aaatccaaaa      900

tgagcctttt attgaatcca gttctctatg tgaccagttc tctgtatgaa tggaagggaa      960

aagaattaaa aatcttgcaa aggggaaaaa aaaaaaaaaa aaa                       1003


<210>  367
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Val Gln Arg Leu Thr Tyr Arg Arg Arg Leu Ser Tyr Asn Thr Ala 
1               5                   10                  15      


Ser Asn Lys Thr Arg Leu Ser Arg Thr Pro Gly Asn Arg Ile Val Tyr 
            20                  25                  30          


Leu Tyr Thr Lys Lys Val Gly Lys Ala Pro Lys Ser Ala Cys Gly Val 
        35                  40                  45              


Cys Pro Gly Arg Leu Arg Gly Val Arg Ala Val Arg Pro Lys Val Leu 
    50                  55                  60                  


Met Arg Leu Ser Lys Thr Lys Lys His Val Ser Arg Ala Tyr Gly Gly 
65                  70                  75                  80  


Ser Met Cys Ala Lys Cys Val Arg Asp Arg Ile Lys Arg Ala Phe Leu 
                85                  90                  95      


Ile Glu Glu Gln Lys Ile Val Val Lys Val Leu Lys Ala Gln Ala Gln 
            100                 105                 110         


Ser Gln Lys Ala Lys 
        115         


<210>  368
<211>  434
<212>  DNA
<213>  Homo sapiens

<400>  368
acttccgctc gtccgcctaa taccgcgcct gcgcaccgcg tctcttcctt tctgggctcg       60

gacctaggtc gcggcgacat ggccaaacgt accaagaaag tcgggatcgt cggtaaatac      120

gggacccgct atggggcctc cctccggaaa atggtgaaga aaattgaaat cagccagcac      180

gccaagtaca cttgctcttt ctgtggcaaa accaagatga agagacgagc tgtggggatc      240

tggcactgtg gttcctgcat gaagacagtg gctggcggtg cctggacgta caataccact      300

tccgctgtca cggtaaagtc cgccatcaga agactgaagg agttgaaaga ccagtagacg      360

ctcctctact ctttgagaca tcactggcct ataataaatg ggttaattta tgtaacaaaa      420

aaaaaaaaaa aaaa                                                        434


<210>  369
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Ala Lys Arg Thr Lys Lys Val Gly Ile Val Gly Lys Tyr Gly Thr 
1               5                   10                  15      


Arg Tyr Gly Ala Ser Leu Arg Lys Met Val Lys Lys Ile Glu Ile Ser 
            20                  25                  30          


Gln His Ala Lys Tyr Thr Cys Ser Phe Cys Gly Lys Thr Lys Met Lys 
        35                  40                  45              


Arg Arg Ala Val Gly Ile Trp His Cys Gly Ser Cys Met Lys Thr Val 
    50                  55                  60                  


Ala Gly Gly Ala Trp Thr Tyr Asn Thr Thr Ser Ala Val Thr Val Lys 
65                  70                  75                  80  


Ser Ala Ile Arg Arg Leu Lys Glu Leu Lys Asp Gln 
                85                  90          


<210>  370
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  370
cttttcctgt ggcagcagcc gggctgagag gagcgtggct gtctcctctc tccgccatgg       60

cgtgtgctcg cccactgata tcggtgtact ccgaaaaggg ggagtcatct ggcaaaaatg      120

tcactttgcc tgctgtattc aaggctccta ttcgaccaga tattgtgaac tttgttcaca      180

ccaacttgcg caaaaacaac agacagccct atgctgtcag tgaattagca ggtcatcaga      240

ctagtgctga gtcttggggt actggcagag ctgtggctcg aattcccaga gttcgaggtg      300

gtgggactca ccgctctggc cagggtgctt ttggaaacat gtgtcgtgga ggccgaatgt      360

ttgcaccaac caaaacctgg cgccgttggc atcgtagagt gaacacaacc caaaaacgat      420

acgccatctg ttctgccctg gctgcctcag ccctaccagc actggtcatg tctaaaggtc      480

atcgtattga ggaagttcct gaacttcctt tggtagttga agataaagtt gaaggctaca      540

agaagaccaa ggaagctgtt ttgctcctta agaaacttaa agcctggaat gatatcaaaa      600

aggtctatgc ctctcagcga atgagagctg gcaaaggcaa aatgagaaac cgtcgccgta      660

tccagcgcag gggcccgtgc atcatctata atgaggataa tggtatcatc aaggccttca      720

gaaacatccc tggaattact ctgcttaatg taagcaagct gaacattttg aagcttgctc      780

ctggtgggca tgtgggacgt ttctgcattt ggactgaaag tgctttccgg aagttagatg      840

aattgtacgg cacttggcgt aaagccgctt ccctcaagag taactacaat cttcccatgc      900

acaagatgat taatacagat cttagcagaa tcttgaaaag cccagagatc caaagagccc      960

ttcgagcacc acgcaagaag atccatcgca gagtcctaaa gaagaaccca ctgaaaaact     1020

tgagaatcat gttgaagcta aacccatatg caaagaccat gcgccggaac accattcttc     1080

gccaggccag gaatcacaag ctccgggtgg ataaggcagc tgctgcagca gcggcactac     1140

aagccaaatc agatgagaag gcggcggttg caggcaagaa gcctgtggta ggtaagaaag     1200

gaaagaaggc tgctgttggt gttaagaagc agaagaagcc tctggtggga aaaaaggcag     1260

cagctaccaa gaaaccagcc cctgaaaaga agcctgcaga gaagaaacct actacagagg     1320

agaagaagcc tgctgcataa actcttaaat ttgattattc cataaaggtc aaatcatttt     1380

ggacagcttc ttttgaataa agacctgatt atacaggcag tgagaaacat gaaaaaaaaa     1440

aaaaaaaaa                                                             1449


<210>  371
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Ala Cys Ala Arg Pro Leu Ile Ser Val Tyr Ser Glu Lys Gly Glu 
1               5                   10                  15      


Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile 
            20                  25                  30          


Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu Arg Lys Asn Asn 
        35                  40                  45              


Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly His Gln Thr Ser Ala 
    50                  55                  60                  


Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Arg Ile Pro Arg Val Arg 
65                  70                  75                  80  


Gly Gly Gly Thr His Arg Ser Gly Gln Gly Ala Phe Gly Asn Met Cys 
                85                  90                  95      


Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg Trp His 
            100                 105                 110         


Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser Ala Leu 
        115                 120                 125             


Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His Arg Ile 
    130                 135                 140                 


Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly 
145                 150                 155                 160 


Tyr Lys Lys Thr Lys Glu Ala Val Leu Leu Leu Lys Lys Leu Lys Ala 
                165                 170                 175     


Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg Ala Gly 
            180                 185                 190         


Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly Pro Cys 
        195                 200                 205             


Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile 
    210                 215                 220                 


Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu Lys Leu 
225                 230                 235                 240 


Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu Ser Ala 
                245                 250                 255     


Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala Ala Ser 
            260                 265                 270         


Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Ile Asn Thr Asp 
        275                 280                 285             


Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu Arg Ala 
    290                 295                 300                 


Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro Leu Lys 
305                 310                 315                 320 


Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr Met Arg 
                325                 330                 335     


Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg Val Asp 
            340                 345                 350         


Lys Ala Ala Ala Ala Ala Ala Ala Leu Gln Ala Lys Ser Asp Glu Lys 
        355                 360                 365             


Ala Ala Val Ala Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys 
    370                 375                 380                 


Ala Ala Val Gly Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Lys Pro Ala Pro Glu Lys Lys Pro Ala Glu Lys 
                405                 410                 415     


Lys Pro Thr Thr Glu Glu Lys Lys Pro Ala Ala 
            420                 425         


<210>  372
<211>  890
<212>  DNA
<213>  Homo sapiens

<400>  372
tttcctttct ctctcctccc gccgcccaag atgccgaaag gaaagaaggc caagggaaag       60

aaggtggctc cggccccagc tgtcgtgaag aagcaggagg ctaagaaagt ggtgaatccc      120

ctgtttgaga aaaggcctaa gaattttggc attggacagg acatccagcc caaaagagac      180

ctcacccgct ttgtgaaatg gccccgctat atcaggttgc agcggcagag agccatcctc      240

tataagcggc tgaaagtgcc tcctgcgatt aaccagttca cccaggccct ggaccgccaa      300

acagctactc agctgcttaa gctggcccac aagtacagac cagagacaaa gcaagagaag      360

aagcagagac tgttggcccg ggccgagaag aaggctgctg gcaaagggga cgtcccaacg      420

aagagaccac ctgtccttcg agcaggagtt aacaccgtca ccaccttggt ggagaacaag      480

aaagctcagc tggtggtgat tgcacacgac gtggatccca tcgagctggt tgtcttcttg      540

cctgccctgt gtcgtaaaat gggggtccct tactgcatta tcaagggaaa ggcaagactg      600

ggacgtctag tccacaggaa gacctgcacc actgtcgcct tcacacaggt gaactcggaa      660

gacaaaggcg ctttggctaa gctggtggaa gctatcagga ccaattacaa tgacagatac      720

gatgagatcc gccgtcactg gggtggcaat gtcctgggtc ctaagtctgt ggctcgtatc      780

gccaagctcg aaaaggcaaa ggctaaagaa cttgccacta aactgggtta aatgtacact      840

gttgagtttt ctgtacataa aaataattga aataatacaa attttccttc                 890


<210>  373
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Pro Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala Pro 
1               5                   10                  15      


Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe 
            20                  25                  30          


Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys 
        35                  40                  45              


Arg Asp Leu Thr Arg Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln 
    50                  55                  60                  


Arg Gln Arg Ala Ile Leu Tyr Lys Arg Leu Lys Val Pro Pro Ala Ile 
65                  70                  75                  80  


Asn Gln Phe Thr Gln Ala Leu Asp Arg Gln Thr Ala Thr Gln Leu Leu 
                85                  90                  95      


Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Gln 
            100                 105                 110         


Arg Leu Leu Ala Arg Ala Glu Lys Lys Ala Ala Gly Lys Gly Asp Val 
        115                 120                 125             


Pro Thr Lys Arg Pro Pro Val Leu Arg Ala Gly Val Asn Thr Val Thr 
    130                 135                 140                 


Thr Leu Val Glu Asn Lys Lys Ala Gln Leu Val Val Ile Ala His Asp 
145                 150                 155                 160 


Val Asp Pro Ile Glu Leu Val Val Phe Leu Pro Ala Leu Cys Arg Lys 
                165                 170                 175     


Met Gly Val Pro Tyr Cys Ile Ile Lys Gly Lys Ala Arg Leu Gly Arg 
            180                 185                 190         


Leu Val His Arg Lys Thr Cys Thr Thr Val Ala Phe Thr Gln Val Asn 
        195                 200                 205             


Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile Arg Thr 
    210                 215                 220                 


Asn Tyr Asn Asp Arg Tyr Asp Glu Ile Arg Arg His Trp Gly Gly Asn 
225                 230                 235                 240 


Val Leu Gly Pro Lys Ser Val Ala Arg Ile Ala Lys Leu Glu Lys Ala 
                245                 250                 255     


Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly 
            260                 265     


<210>  374
<211>  549
<212>  DNA
<213>  Homo sapiens

<400>  374
ctctcttcca caggaggcct acacgccgcc gcttgtgctg cagccatgtc tctagtgatc       60

cctgaaaagt tccagcatat tttgcgagta ctcaacacca acatcgatgg gcggcggaaa      120

atagcctttg ccatcactgc cattaagggt gtgggccgaa gatatgctca tgtggtgttg      180

aggaaagcag acattgacct caccaagagg gcgggagaac tcactgagga tgaggtggaa      240

cgtgtgatca ccattatgca gaatccacgc cagtacaaga tcccagactg gttcttgaac      300

agacagaagg atgtaaagga tggaaaatac agccaggtcc tagccaatgg tctggacaac      360

aagctccgtg aagacctgga gcgactgaag aagattcggg cccatagagg gctgcgtcac      420

ttctggggcc ttcgtgtccg aggccagcac accaagacca ctggccgccg tggccgcacc      480

gtgggtgtgt ccaagaagaa ataagtctgt aggccttgtc tgttaataaa tagtttatat      540

acaaaaaaa                                                              549


<210>  375
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu 
1               5                   10                  15      


Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala 
            20                  25                  30          


Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala 
        35                  40                  45              


Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val 
    50                  55                  60                  


Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro 
65                  70                  75                  80  


Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser 
                85                  90                  95      


Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu 
            100                 105                 110         


Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly 
        115                 120                 125             


Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg 
    130                 135                 140                 


Thr Val Gly Val Ser Lys Lys Lys 
145                 150         


<210>  376
<211>  1109
<212>  DNA
<213>  Homo sapiens

<400>  376
ggctggattc ccgtcgtaac ttaaagggaa attttcacaa tgtccggagc ccttgatgtc       60

ctgcaaatga aggaggagga tgtccttaag ttccttgcag caggaaccca cttaggtggc      120

accaatcttg acttccagat ggaacagtac atctataaaa ggaaaagtga tggcatctat      180

atcataaatc tcaagaggac ctgggagaag cttctgctgg cagctcgtgc aattgttgcc      240

attgaaaacc ctgctgatgt cagtgttata tcctccagga atactggcca gagggctgtg      300

ctgaagtttg ctgctgccac tggagccact ccaattgctg gccgcttcac tcctggaacc      360

ttcactaacc agatccaggc agccttccgg gagccacggc ttcttgtggt tactgacccc      420

agggctgacc accagcctct cacggaggca tcttatgtta acctacctac cattgcgctg      480

tgtaacacag attctcctct gcgctatgtg gacattgcca tcccatgcaa caacaaggga      540

gctcactcag tgggtttgat gtggtggatg ctggctcggg aagttctgcg catgcgtggc      600

accatttccc gtgaacaccc atgggaggtc atgcctgatc tgtacttcta cagagatcct      660

gaagagattg aaaaagaaga gcaggctgct gctgagaagg cagtgaccaa ggaggaattt      720

cagggtgaat ggactgctcc cgctcctgag ttcactgcta ctcagcctga ggttgcagac      780

tggtctgaag gtgtacaggt gccctctgtg cctattcagc aattccctac tgaagactgg      840

agcgctcagc ctgccacgga agactggtct gcagctccca ctgctcaggc cactgaatgg      900

gtaggagcaa ccactgactg gtcttaagct gttcttgcat aggctcttaa gcagcatgga      960

aaaatggttg atggaaaata aacatcagtt tctaaaagtt gtcttcattt agtttgcttt     1020

ttactccaga tcagaatacc tgggattgca tatcaaagca taataataaa tacatgtctc     1080

gacatgagtt gtacttctaa aaaaaaaaa                                       1109


<210>  377
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp 
                165                 170                 175     


Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255     


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala 
            260                 265                 270         


Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285             


Gly Ala Thr Thr Asp Trp Ser 
    290                 295 


<210>  378
<211>  1155
<212>  DNA
<213>  Homo sapiens

<400>  378
cgcctgtctt ttccgtgcta cctgcagagg ggtccatacg gcgttgttct ggattcccgt       60

cgtaacttaa agggaaattt tcacaatgtc cggagccctt gatgtcctgc aaatgaagga      120

ggaggatgtc cttaagttcc ttgcagcagg aacccactta ggtggcacca atcttgactt      180

ccagatggaa cagtacatct ataaaaggaa aagtgatggc atctatatca taaatctcaa      240

gaggacctgg gagaagcttc tgctggcagc tcgtgcaatt gttgccattg aaaaccctgc      300

tgatgtcagt gttatatcct ccaggaatac tggccagagg gctgtgctga agtttgctgc      360

tgccactgga gccactccaa ttgctggccg cttcactcct ggaaccttca ctaaccagat      420

ccaggcagcc ttccgggagc cacggcttct tgtggttact gaccccaggg ctgaccacca      480

gcctctcacg gaggcatctt atgttaacct acctaccatt gcgctgtgta acacagattc      540

tcctctgcgc tatgtggaca ttgccatccc atgcaacaac aagggagctc actcagtggg      600

tttgatgtgg tggatgctgg ctcgggaagt tctgcgcatg cgtggcacca tttcccgtga      660

acacccatgg gaggtcatgc ctgatctgta cttctacaga gatcctgaag agattgaaaa      720

agaagagcag gctgctgctg agaaggcagt gaccaaggag gaatttcagg gtgaatggac      780

tgctcccgct cctgagttca ctgctactca gcctgaggtt gcagactggt ctgaaggtgt      840

acaggtgccc tctgtgccta ttcagcaatt ccctactgaa gactggagcg ctcagcctgc      900

cacggaagac tggtctgcag ctcccactgc tcaggccact gaatgggtag gagcaaccac      960

tgactggtct taagctgttc ttgcataggc tcttaagcag catggaaaaa tggttgatgg     1020

aaaataaaca tcagtttcta aaagttgtct tcatttagtt tgctttttac tccagatcag     1080

aatacctggg attgcatatc aaagcataat aataaataca tgtctcgaca tgagttgtac     1140

ttctaaaaaa aaaaa                                                      1155


<210>  379
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp 
                165                 170                 175     


Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255     


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala 
            260                 265                 270         


Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285             


Gly Ala Thr Thr Asp Trp Ser 
    290                 295 


<210>  380
<211>  1075
<212>  DNA
<213>  Homo sapiens

<400>  380
gttttcttcg aagatttggg gctccgcgat acagttagga tggctgtagt acctctgctg       60

ttgttggggg gtttgtggag cgctgtggga gcgtccagcc tgggtgtcgt tacttgcggc      120

tccgtggtga agctactcaa tacgcgccac aacgtccgac tgcactcaca cgacgtgcgc      180

tatgggtcag gtagtgggca gcagtcagtg acaggtgtaa cctctgtgga tgacagcaac      240

agttactgga ggatacgggg gaagagtgcc acagtgtgtg agaggggaac ccccatcaag      300

tgtggccagc ccatccggct gacacatgtc aacactggcc gaaacctcca tagtcaccac      360

ttcacttcac ctctttctgg aaaccaggaa gtgagtgctt ttggtgagga aggtgaaggt      420

gattatctgg atgactggac agtgctctgt aatggaccct actgggtgag agatggtgag      480

gtgcggttca aacactcttc cactgaggta ctgctgtctg tcacaggaga acaatatggt      540

cgacctatca gtgggcaaaa agaggtgcat ggcatggccc agccaagtca gaacaactac      600

tggaaagcca tggaaggcat cttcatgaag cccagtgagt tgttgaaggc agaagcccac      660

catgcagagc tgtgaatcta gaggctctga gccactgtta acgcacaatg ttcacagaca      720

tctgttgctg cctcaccttg ggatccctgc cacaagttcc ttgggcagtg gccatgtcac      780

cattgagatg aagatataca acagaaaata gtggctgtgt ttggaagctt cagccctgca      840

catttgaact agtcactctc ccagacttgc gtgggtcagt tctttctgag tagaggactt      900

gctggtaaag gggcagatgc tttttattag tactgataaa acaaactgag ggaaacatcc      960

ctcttagctg ggaaactttt actcttcagg agcttggcat catggactgt taatgtatgt     1020

gattttcccc ctattttctc tctccaaaat gataaaaaca ataattttat tatga          1075


<210>  381
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Ala Val Val Pro Leu Leu Leu Leu Gly Gly Leu Trp Ser Ala Val 
1               5                   10                  15      


Gly Ala Ser Ser Leu Gly Val Val Thr Cys Gly Ser Val Val Lys Leu 
            20                  25                  30          


Leu Asn Thr Arg His Asn Val Arg Leu His Ser His Asp Val Arg Tyr 
        35                  40                  45              


Gly Ser Gly Ser Gly Gln Gln Ser Val Thr Gly Val Thr Ser Val Asp 
    50                  55                  60                  


Asp Ser Asn Ser Tyr Trp Arg Ile Arg Gly Lys Ser Ala Thr Val Cys 
65                  70                  75                  80  


Glu Arg Gly Thr Pro Ile Lys Cys Gly Gln Pro Ile Arg Leu Thr His 
                85                  90                  95      


Val Asn Thr Gly Arg Asn Leu His Ser His His Phe Thr Ser Pro Leu 
            100                 105                 110         


Ser Gly Asn Gln Glu Val Ser Ala Phe Gly Glu Glu Gly Glu Gly Asp 
        115                 120                 125             


Tyr Leu Asp Asp Trp Thr Val Leu Cys Asn Gly Pro Tyr Trp Val Arg 
    130                 135                 140                 


Asp Gly Glu Val Arg Phe Lys His Ser Ser Thr Glu Val Leu Leu Ser 
145                 150                 155                 160 


Val Thr Gly Glu Gln Tyr Gly Arg Pro Ile Ser Gly Gln Lys Glu Val 
                165                 170                 175     


His Gly Met Ala Gln Pro Ser Gln Asn Asn Tyr Trp Lys Ala Met Glu 
            180                 185                 190         


Gly Ile Phe Met Lys Pro Ser Glu Leu Leu Lys Ala Glu Ala His His 
        195                 200                 205             


Ala Glu Leu 
    210     


<210>  382
<211>  5189
<212>  DNA
<213>  Homo sapiens

<400>  382
ggactgcgaa aggagcaggg ttgcggagct agggctccag cctgcggccg cgcattcttg       60

cgtctggcca gccgcgagct ctaagggtcg gccccgcccg gtccgccccc gcggctccct      120

gccaggctct cgcgggcgcg ctcggggtgg ggcctcgcgg ctggcggaga tgcggccggg      180

gctgcgcggt ggtgatgcga gcctgctggg cggcgcgccg gggcagccgg agccgcgcgc      240

cgcggcgctg taatcggaca ccaagagcgc tcgcccccgg cctccggcca ctttccattc      300

actccgaggt gcttgattga gcgacgcgga gaagagctcc gggtgccgcg gcactgcagc      360

gctgagattc ctttacaaag aaactcagag gaccgggaag aaagaatttc acctttgcga      420

cgtgctagaa aataaggtcg tctgggaaaa ggactggaga cacaagcgca tccaaccccg      480

gtagcaaact gatgactttt ccgtgctgat ttctttcaac ctcggtattt tcccttggat      540

attaacttgc atatctgaag aaatggcatt ccggacaatt tgcgtgttgg ttggagtatt      600

tatttgttct atctgtgtga aaggatcttc ccagccccaa gcaagagttt atttaacatt      660

tgatgaactt cgagaaacca agacctctga atacttcagc ctttcccacc atcctttaga      720

ctacaggatt ttattaatgg atgaagatca ggaccggata tatgtgggaa gcaaagatca      780

cattctttcc ctgaatatta acaatataag tcaagaagct ttgagtgttt tctggccagc      840

atctacaatc aaagttgaag aatgcaaaat ggctggcaaa gatcccacac acggctgtgg      900

gaactttgtc cgtgtaattc agactttcaa tcgcacacat ttgtatgtct gtgggagtgg      960

cgctttcagt cctgtctgta cttacttgaa cagagggagg agatcagagg accaagtttt     1020

catgattgac tccaagtgtg aatctggaaa aggacgctgc tctttcaacc ccaacgtgaa     1080

cacggtgtct gttatgatca atgaggagct tttctctgga atgtatatag atttcatggg     1140

gacagatgct gctatttttc gaagtttaac caagaggaat gcggtcagaa ctgatcaaca     1200

taattccaaa tggctaagtg aacctatgtt tgtagatgca catgtcatcc cagatggtac     1260

tgatccaaat gatgctaagg tgtacttctt cttcaaagaa aaactgactg acaataacag     1320

gagcacgaaa cagattcatt ccatgattgc tcgaatatgt cctaatgaca ctggtggact     1380

gcgtagcctt gtcaacaagt ggaccacttt cttaaaggcg aggctggtgt gctcggtaac     1440

agatgaagac ggcccagaaa cacactttga tgaattagag gatgtgtttc tgctggaaac     1500

tgataacccg aggacaacac tagtgtatgg catttttaca acatcaagct cagttttcaa     1560

aggatcagcc gtgtgtgtgt atcatttatc tgatatacag actgtgttta atgggccttt     1620

tgcccacaaa gaagggccca atcatcagct gatttcctat cagggcagaa ttccatatcc     1680

tcgccctgga acttgtccag gaggagcatt tacacccaat atgcgaacca ccaaggagtt     1740

cccagatgat gttgtcactt ttattcggaa ccatcctctc atgtacaatt ccatctaccc     1800

aatccacaaa aggcctttga ttgttcgtat tggcactgac tacaagtata caaagatagc     1860

tgtggatcga gtgaacgctg ctgatgggag ataccatgtc ctgtttctcg gaacagatcg     1920

gggtactgtg caaaaagtgg ttgttcttcc tactaacaac tctgtcagtg gcgagctcat     1980

tctggaggag ctggaagtct ttaagaatca tgctcctata acaacaatga aaatttcatc     2040

taaaaagcaa cagttgtatg tgagttccaa tgaaggggtt tcccaggtat ctctgcaccg     2100

ctgccacatc tatggtacag cctgtgctga ctgctgcctg gcgcgggacc cttattgcgc     2160

ctgggatggc cattcctgtt ccagattcta cccaactggg aaacggagga gccgaagaca     2220

agatgtgaga catggaaacc cactgactca atgcagagga tttaatctaa aagcatacag     2280

aaatgcagct gaaattgtgc agtatggagt aaaaaataac accacttttc tggagtgtgc     2340

ccccaagtct ccgcaggcat ctatcaagtg gctgttacag aaagacaaag acaggaggaa     2400

agaggttaag ctgaatgaac gaataatagc cacttcacag ggactcctga tccgctctgt     2460

tcagggttct gaccaaggac tttatcactg cattgctaca gaaaatagtt tcaagcagac     2520

catagccaag atcaacttca aagttttaga ttcagaaatg gtggctgttg tgacggacaa     2580

atggtcccca tggacctggg ccagctctgt gagggcttta cccttccacc cgaaggacat     2640

catgggggca ttcagccact cagaaatgca gatgattaac caatattgca aagacactcg     2700

gcagcaacat cagcagggag atgaatcaca gaaaatgaga ggggactatg gcaagttaaa     2760

ggccctcatc aatagtcgga aaagtagaaa caggaggaat cagttgccag agtcataata     2820

ttttcttatg tgggtcttat gcttccatta acaaatgctc tgtcttcaat gatcaaattt     2880

tgagcaaaga aacttgtgct ttaccaaggg gaattactga aaaaggtgat tactcctgaa     2940

gtgagtttta cacgaactga aatgagcatg cattttcttg tatgatagtg actagcacta     3000

gacatgtcat ggtcctcatg gtgcatataa atatatttaa cttaacccag attttattta     3060

tatctttatt caccttttct tcaaaatcga tatggtggct gcaaaactag aattgttgca     3120

tccctcaatt gaatgagggc catatccctg tggtattcct ttcctgcttt ggggctttag     3180

aattctaatt gtcagtgatt ttgtatatga aaacaagttc caaatccaca gcttttacgt     3240

agtaaaagtc ataaatgcat atgacagaat ggctatcaaa agaaatagaa aaggaagacg     3300

gcatttaaag ttgtataaaa acacgagtta ttcataaaga gaaaatgatg agtttttatg     3360

gttccaatga aatatgttgg ggttttttta agattgtaaa aataatcagt tactggtatc     3420

tgtcactgac ctttgtttcc ttattcagga agataaaaat cagtaaccta ccccatgaag     3480

atatttggtg ggagttatat cagtgaagca gtttggttta tattcttatg ttatcacctt     3540

ccaaacaaaa gcacttactt tttttggaag ttatttattt tagactcaaa gaatataatc     3600

ttgcactact cagttattac tgtttgttct cttattccct agtctgtgtg gcaaattaaa     3660

caatataaga aggaaaaatt tgaagtatta gacttctaaa taaggggtga aatcatcaga     3720

aagaaaaatc aaagtagaaa ctactaattt tttaagagga atttataaca aatatggcta     3780

gttttcaact tcagtactca aattcaatga ttcttccttt tattaaaacc agtctcagat     3840

atcatactga tttttaagtc aacactatat attttatgat cttttcagtg tgatggcaag     3900

gtgcttgtta tgtctagaaa gtaagaaaac aatatgagga gacattctgt ctttcaaaag     3960

gtaatggtac atacgttcac tggtctctaa gtgtaaaagt agtaaatttt gtgatgaata     4020

aaataattat ctcctaattg tatgttagaa taattttatt agaataattt catactgaaa     4080

ttattttctc caaataaaaa ttagatggaa aaatgtgaaa aaaattattc atgctctcat     4140

atatatttta aaaacactac ttttgctttt ttatttacct tttaagacat tttcatgctt     4200

ccaggtaaaa acagatattg taccatgtac ctaatccaaa tatcatataa acattttatt     4260

tatagttaat aatctatgat gaaggtaatt aaagtagatt atggcctttt taagtattgc     4320

agtctaaaac ttcaaaaact aaaatcattg tcaaaattaa tatgattatt aatcagaata     4380

tcagaatatg attcactatt taaactatga taaattatga taatatatga ggaggcctcg     4440

ctatagcaaa aatagttaaa atgctgacat aacaccaaac ttcatttttt aaaaaatctg     4500

ttgttccaaa tgtgtataat tttaaagtaa tttctaaagc agtttattat aatggtttgc     4560

ctgcttaaaa ggtataatta aacttctttt ctcttctaca ttgacacaca gaaatgtgtc     4620

aatgtaaagc caaaaccatc ttctgtgttt atggccaatc tattctcaaa gttaaaagta     4680

aaattgtttc agagtcacag ttccctttat ttcacataag cccaaactga tagacagtaa     4740

cggtgtttag ttttatacta tatttgtgct atttaattct ttctattttc acaattatta     4800

aattgtgtac actttcatta cttttaaaaa tgtagaaatt cttcatgaac ataactctgc     4860

tgaatgtaaa agaaaatttt ttttcaaaaa tgctgttaat gtatactact ggtggttgat     4920

tggttttatt ttatgtagct tgacaattca gtgacttaat atctattcca tttgtattgt     4980

acataaaatt ttctagaaat acactttttt ccaaagtgta agtttgtgaa tagattttag     5040

catgatgaaa ctgtcataat ggtgaatgtt caatctgtgt aagaaaacaa actaaatgta     5100

gttgtcacac taaaatttaa ttggatattg atgaaatcat tggcctggca aaataaaaca     5160

tgttgaattc cccaaaaaaa aaaaaaaaa                                       5189


<210>  383
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Arg Arg Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Arg Lys Ser Arg Asn Arg Arg Asn Gln Leu Pro Glu Ser 
            740                 745                 750     


<210>  384
<211>  3969
<212>  DNA
<213>  Homo sapiens

<400>  384
agagcgggcc gagggggcgg ggtcacgagc cgccagccgc cgggtggagg gtcccggccg       60

ggagccgcgg aaagagtagg gctccccaga caacggggtc cgacgagcag ttgggcacgg      120

gctgagtccg cctgccggca gaatgtccct ggctgcttat tgcgtcatct gttgcagaag      180

aataggaacc tctacttccc caccaaaaag tggcacacac tggagagata tcagaaatat      240

aataaagttt actggatcac ttattttagg aggttcttta tttcttacat atgaagttct      300

ggccctgaag aaggctgtga cattagatac tcaagtggta gaacgagaaa aaatgaagtc      360

atatatatat gtgcacacag tttctttaga caaaggagaa aatcatggta ttgcctggca      420

ggcaagaaaa gaacttcaca aagcagtaag aaaagtattg gcaacatcag ccaagatact      480

gcggaatcca tttgctgatc cttttagtac agttgatata gaagatcatg agtgtgctgt      540

gtggctgctc ctacggaaga gcaagtcaga tgacaaaacc acgcgactcg aggctgtgcg      600

ggaaatgtcg gagacccatc actggcatga ttaccagtat aggataattg ctcaagcctg      660

tgatccgaaa actcttattg gtttggcacg aagcgaagag agtgatcttc gcttttttct      720

cctaccacct cctttgccat ctttaaaaga agattcttcc actgaagaag agctcagaca      780

gttgctggct tccttacctc aaacagagct agatgagtgt atccagtatt ttacatcttt      840

ggctcttagt gaaagcagtc agagtctagc tgctcagaag ggtggtttat ggtgttttgg      900

aggaaatgga cttccttatg ctgaaagttt tggagaagtt ccttcagcaa cagtggaaat      960

gttctgttta gaagctatag taaaacattc tgagatatcc acacattgtg ataaaatcga     1020

agcaaatgga ggcctgcagc tacttcagag gctgtaccga cttcacaagg actgccctaa     1080

agtacagaga aatataatgc gtgtcattgg aaatatggct ttgaatgaac atcttcattc     1140

ttctatagtt cgctcaggct gggtttccat catggcagaa gcaatgaaat ctccccacat     1200

tatggagtcc tcacacgctg ccagaatcct ggcaaatcta gaccgagaaa ctgtgcaaga     1260

aaaatatcag gatggcgtat atgtgctgca tccccaatat cgaacaagtc agcccattaa     1320

agcagatgtc ctttttattc atggccttat gggagcagca ttcaaaacat ggcgccagca     1380

ggacagtgag caggctgtaa ttgaaaaacc tatggaggat gaagacagat atacgacgtg     1440

ctggcccaag acatggttag caaaagactg tcctgctctc cgaattatat ctgtggagta     1500

tgacaccagc ctcagcgact ggagagcaag gtgccctatg gaaagaaagt ccattgcatt     1560

cagaagcaac gaacttctta ggaagctcag agctgctggt gttggggata ggccagtggt     1620

ttggatatca catagcatgg gaggtcttct tgtcaaaaag atgctgttgg aagcctctac     1680

gaagccagaa atgagtactg ttatcaacaa taccagagga ataatttttt atagtgtccc     1740

tcatcatgga tcacgtttgg ctgaatactc tgttaatatt cgctatcttc tcttcccctc     1800

gttggaagtc aaagaactca gcaaggattc tcctgcactt aaaacactac aagatgactt     1860

tctggagttt gctaaagaca aaaacttcca ggtgctgaat tttgtggaaa cactaccaac     1920

ctacattggc agcatgatta agctccatgt ggtacctgtg gaatcagcag atttaggcat     1980

tggagatcta attcctgtgg atgttaacca tttgaacatt tgtaagccaa agaaaaagga     2040

tgcttttttg taccagcgta ctttacaatt cattcgtgaa gctttagcca aagaccttga     2100

aaactaacag ttgtgctctt ccagttttca tatgtgaatt cagtgcaaga aacttggtgt     2160

tctgtttctt cttttaagct ctatgcaatc atgcaaacat agtgatcata gcgtcaacat     2220

ggtctggagt gtgttgcaga ctacagaaca ttgttctccc ttcaagcgct gtaaagcacc     2280

aacccggaag tggcaggcac agaaggaagg gctggattgg gcccctttgg tgtaaagaag     2340

tccctgtgtg ctgctttatg gttcgcagtg ttgggcttgg tgactggagc aaagctgctg     2400

tgagagagtg tcctttccca tctgtgactt tcctggtgca tccaggaggg gcacggcagg     2460

ttctgaggta actcaactta ccataaaaat gccattaaga gagtacctaa aatggagaga     2520

agaatgaact agaacattca agactctttt acttctgggt attgatttgc tgtacatttt     2580

taaagtttga gtttttagct cagttctacc ttttatctga cacattatta ctagtgttaa     2640

ctttgttaga cttattgtca tgtctgggtc agttccttgt atctattttc gtattcctga     2700

gaacaaatct ttttcttaga aaaattctag cttataataa ttcttttcag actgtagctg     2760

cctatgcttg gaatttgtcc tagataagga taaagtagct aatccattat tgatcacagt     2820

atgaagtaaa actattctaa gccattatat gaattagcaa ttcttagtat caagattctc     2880

agattctctt tggctaaata aacctttctt cttccttgct catttgcaag tggtattaat     2940

tgacctctat agcatgtgag tagtagataa tcatgtcgat gacctttttt tctttagagt     3000

aacagcatta ttgagatata atttacatac cataagattc acccttttaa attatacaat     3060

tcatttttgt tttgttttgt ttgtttagag acagggtctg actctgttgc ccaagctgga     3120

gtgcagtggc atgatcatag ctcattgtaa cctcaaactc ctgggctcaa gagatccttt     3180

tgcttcagcc tcccaagcag ctaggactac aggcacatgc caccacactt gggtaattaa     3240

aaaataaata aatacttttt tgtagagaca gggtctcact gtgttgccca ggtctcaaac     3300

tcccgatctc aagccaccct cccaaaatgc tgtgattata ggccagagcc attgttccca     3360

ggctcaattc attggttttt agtatagttc actgagttgt gcaacatcat tgctatttaa     3420

tttcaggcta tttcatcatc cccaaaagaa ccccataccc atgagcagtc agttcccacc     3480

tctgctttcc caagcctgcg gtaaacacta atctgttttc tgtctctatg gatttgggaa     3540

ttttatgtaa atggaatcat acaatatgtg gccctctctg ccttcttcct tctattagca     3600

tgttttcaag gttcattcat gatatagcat gtatcagtac tacttcattt ctttttatgg     3660

ccgaaattac tccattgtat gatatgccat gtttctttat ccattcatca gctgatggac     3720

atctaggttc tgttcatttt tgtctatgat aaataatgct accatgatca tttgtgtaca     3780

aatttatgtg tggatagatg tttttgattc tcttgggtgg aattgctggt caaatggtaa     3840

gtctatgttt aaattttgaa gatggtgaac ttttgtagaa tgagatagtc gaagctaaaa     3900

ctggagtatg gcatctgaag gtaaatggct catcaataaa ctcgatatca acaattaatt     3960

gtttcattg                                                             3969


<210>  385
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ser Leu Ala Ala Tyr Cys Val Ile Cys Cys Arg Arg Ile Gly Thr 
1               5                   10                  15      


Ser Thr Ser Pro Pro Lys Ser Gly Thr His Trp Arg Asp Ile Arg Asn 
            20                  25                  30          


Ile Ile Lys Phe Thr Gly Ser Leu Ile Leu Gly Gly Ser Leu Phe Leu 
        35                  40                  45              


Thr Tyr Glu Val Leu Ala Leu Lys Lys Ala Val Thr Leu Asp Thr Gln 
    50                  55                  60                  


Val Val Glu Arg Glu Lys Met Lys Ser Tyr Ile Tyr Val His Thr Val 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Glu Asn His Gly Ile Ala Trp Gln Ala Arg Lys 
                85                  90                  95      


Glu Leu His Lys Ala Val Arg Lys Val Leu Ala Thr Ser Ala Lys Ile 
            100                 105                 110         


Leu Arg Asn Pro Phe Ala Asp Pro Phe Ser Thr Val Asp Ile Glu Asp 
        115                 120                 125             


His Glu Cys Ala Val Trp Leu Leu Leu Arg Lys Ser Lys Ser Asp Asp 
    130                 135                 140                 


Lys Thr Thr Arg Leu Glu Ala Val Arg Glu Met Ser Glu Thr His His 
145                 150                 155                 160 


Trp His Asp Tyr Gln Tyr Arg Ile Ile Ala Gln Ala Cys Asp Pro Lys 
                165                 170                 175     


Thr Leu Ile Gly Leu Ala Arg Ser Glu Glu Ser Asp Leu Arg Phe Phe 
            180                 185                 190         


Leu Leu Pro Pro Pro Leu Pro Ser Leu Lys Glu Asp Ser Ser Thr Glu 
        195                 200                 205             


Glu Glu Leu Arg Gln Leu Leu Ala Ser Leu Pro Gln Thr Glu Leu Asp 
    210                 215                 220                 


Glu Cys Ile Gln Tyr Phe Thr Ser Leu Ala Leu Ser Glu Ser Ser Gln 
225                 230                 235                 240 


Ser Leu Ala Ala Gln Lys Gly Gly Leu Trp Cys Phe Gly Gly Asn Gly 
                245                 250                 255     


Leu Pro Tyr Ala Glu Ser Phe Gly Glu Val Pro Ser Ala Thr Val Glu 
            260                 265                 270         


Met Phe Cys Leu Glu Ala Ile Val Lys His Ser Glu Ile Ser Thr His 
        275                 280                 285             


Cys Asp Lys Ile Glu Ala Asn Gly Gly Leu Gln Leu Leu Gln Arg Leu 
    290                 295                 300                 


Tyr Arg Leu His Lys Asp Cys Pro Lys Val Gln Arg Asn Ile Met Arg 
305                 310                 315                 320 


Val Ile Gly Asn Met Ala Leu Asn Glu His Leu His Ser Ser Ile Val 
                325                 330                 335     


Arg Ser Gly Trp Val Ser Ile Met Ala Glu Ala Met Lys Ser Pro His 
            340                 345                 350         


Ile Met Glu Ser Ser His Ala Ala Arg Ile Leu Ala Asn Leu Asp Arg 
        355                 360                 365             


Glu Thr Val Gln Glu Lys Tyr Gln Asp Gly Val Tyr Val Leu His Pro 
    370                 375                 380                 


Gln Tyr Arg Thr Ser Gln Pro Ile Lys Ala Asp Val Leu Phe Ile His 
385                 390                 395                 400 


Gly Leu Met Gly Ala Ala Phe Lys Thr Trp Arg Gln Gln Asp Ser Glu 
                405                 410                 415     


Gln Ala Val Ile Glu Lys Pro Met Glu Asp Glu Asp Arg Tyr Thr Thr 
            420                 425                 430         


Cys Trp Pro Lys Thr Trp Leu Ala Lys Asp Cys Pro Ala Leu Arg Ile 
        435                 440                 445             


Ile Ser Val Glu Tyr Asp Thr Ser Leu Ser Asp Trp Arg Ala Arg Cys 
    450                 455                 460                 


Pro Met Glu Arg Lys Ser Ile Ala Phe Arg Ser Asn Glu Leu Leu Arg 
465                 470                 475                 480 


Lys Leu Arg Ala Ala Gly Val Gly Asp Arg Pro Val Val Trp Ile Ser 
                485                 490                 495     


His Ser Met Gly Gly Leu Leu Val Lys Lys Met Leu Leu Glu Ala Ser 
            500                 505                 510         


Thr Lys Pro Glu Met Ser Thr Val Ile Asn Asn Thr Arg Gly Ile Ile 
        515                 520                 525             


Phe Tyr Ser Val Pro His His Gly Ser Arg Leu Ala Glu Tyr Ser Val 
    530                 535                 540                 


Asn Ile Arg Tyr Leu Leu Phe Pro Ser Leu Glu Val Lys Glu Leu Ser 
545                 550                 555                 560 


Lys Asp Ser Pro Ala Leu Lys Thr Leu Gln Asp Asp Phe Leu Glu Phe 
                565                 570                 575     


Ala Lys Asp Lys Asn Phe Gln Val Leu Asn Phe Val Glu Thr Leu Pro 
            580                 585                 590         


Thr Tyr Ile Gly Ser Met Ile Lys Leu His Val Val Pro Val Glu Ser 
        595                 600                 605             


Ala Asp Leu Gly Ile Gly Asp Leu Ile Pro Val Asp Val Asn His Leu 
    610                 615                 620                 


Asn Ile Cys Lys Pro Lys Lys Lys Asp Ala Phe Leu Tyr Gln Arg Thr 
625                 630                 635                 640 


Leu Gln Phe Ile Arg Glu Ala Leu Ala Lys Asp Leu Glu Asn 
                645                 650                 


<210>  386
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  386
agctgccaaa ttcgccaact agaggaggga gaggcggagc ttgggtccct gtagaagcca       60

gaggcgcagt ctggactgta gtttcccggg agagacgaaa gcaggaacga gagcggagcg      120

gagcacagtc cgccgagcac aagctccagc atcccgtcag gggttgcagg tgtgtgggag      180

gcttgaaact gttacaatat ggctttcctt ggactcttct ctttgctggt tctgcaaagt      240

atggctacag gggccacttt ccctgaggaa gccattgctg acttgtcagt gaatatgtat      300

aatcgtctta gagccactgg tgaagatgaa aatattctct tctctccatt gagtattgct      360

cttgcaatgg gaatgatgga acttggggcc caaggatcta cccagaaaga aatccgccac      420

tcaatgggat atgacagcct aaaaaatggt gaagaatttt ctttcttgaa ggagttttca      480

aacatggtaa ctgctaaaga gagccaatat gtgatgaaaa ttgccaattc cttgtttgtg      540

caaaatggat ttcatgtcaa tgaggagttt ttgcaaatga tgaaaaaata ttttaatgca      600

gcagtaaatc atgtggactt cagtcaaaat gtagccgtgg ccaactacat caataagtgg      660

gtggagaata acacaaacaa tctggtgaaa gatttggtat ccccaaggga ttttgatgct      720

gccacttatc tggccctcat taatgctgtc tatttcaagg ggaactggaa gtcgcagttt      780

aggcctgaaa atactagaac cttttctttc actaaagatg atgaaagtga agtccaaatt      840

ccaatgatgt atcagcaagg agaattttat tatggggaat ttagtgatgg ctccaatgaa      900

gctggtggta tctaccaagt cctagaaata ccatatgaag gagatgaaat aagcatgatg      960

ctggtgctgt ccagacagga agttcctctt gctactctgg agccattagt caaagcacag     1020

ctggttgaag aatgggcaaa ctctgtgaag aagcaaaaag tagaagtata cctgcccagg     1080

ttcacagtgg aacaggaaat tgatttaaaa gatgttttga aggctcttgg aataactgaa     1140

attttcatca aagatgcaaa tttgacaggc ctctctgata ataaggagat ttttctttcc     1200

aaagcaattc acaagtcctt cctagaggtt aatgaagaag gctcagaagc tgctgctgtc     1260

tcaggaatga ttgcaattag taggatggct gtgctgtatc ctcaagttat tgtcgaccat     1320

ccatttttct ttcttatcag aaacaggaga actggtacaa ttctattcat gggacgagtc     1380

atgcatcctg aaacaatgaa cacaagtgga catgatttcg aagaacttta agttacttta     1440

tttgaataac aaggaaaaca gtaactaagc acattatgtt tgcaactggt atatatttag     1500

gatttgtgtt ttacagtata tcttaagata atatttaaaa tagttccaga taaaaacaat     1560

atatgtaaat tataagtaac ttgtcaagga atgttatcag tattaagcta atggtcctgt     1620

tatgtcattg tgtttgtgtg ctgttgttta aaataaaagt acctattgaa catgtgaaaa     1680

aaaaaaaaaa aaaaaa                                                     1696


<210>  387
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ala Phe Leu Gly Leu Phe Ser Leu Leu Val Leu Gln Ser Met Ala 
1               5                   10                  15      


Thr Gly Ala Thr Phe Pro Glu Glu Ala Ile Ala Asp Leu Ser Val Asn 
            20                  25                  30          


Met Tyr Asn Arg Leu Arg Ala Thr Gly Glu Asp Glu Asn Ile Leu Phe 
        35                  40                  45              


Ser Pro Leu Ser Ile Ala Leu Ala Met Gly Met Met Glu Leu Gly Ala 
    50                  55                  60                  


Gln Gly Ser Thr Gln Lys Glu Ile Arg His Ser Met Gly Tyr Asp Ser 
65                  70                  75                  80  


Leu Lys Asn Gly Glu Glu Phe Ser Phe Leu Lys Glu Phe Ser Asn Met 
                85                  90                  95      


Val Thr Ala Lys Glu Ser Gln Tyr Val Met Lys Ile Ala Asn Ser Leu 
            100                 105                 110         


Phe Val Gln Asn Gly Phe His Val Asn Glu Glu Phe Leu Gln Met Met 
        115                 120                 125             


Lys Lys Tyr Phe Asn Ala Ala Val Asn His Val Asp Phe Ser Gln Asn 
    130                 135                 140                 


Val Ala Val Ala Asn Tyr Ile Asn Lys Trp Val Glu Asn Asn Thr Asn 
145                 150                 155                 160 


Asn Leu Val Lys Asp Leu Val Ser Pro Arg Asp Phe Asp Ala Ala Thr 
                165                 170                 175     


Tyr Leu Ala Leu Ile Asn Ala Val Tyr Phe Lys Gly Asn Trp Lys Ser 
            180                 185                 190         


Gln Phe Arg Pro Glu Asn Thr Arg Thr Phe Ser Phe Thr Lys Asp Asp 
        195                 200                 205             


Glu Ser Glu Val Gln Ile Pro Met Met Tyr Gln Gln Gly Glu Phe Tyr 
    210                 215                 220                 


Tyr Gly Glu Phe Ser Asp Gly Ser Asn Glu Ala Gly Gly Ile Tyr Gln 
225                 230                 235                 240 


Val Leu Glu Ile Pro Tyr Glu Gly Asp Glu Ile Ser Met Met Leu Val 
                245                 250                 255     


Leu Ser Arg Gln Glu Val Pro Leu Ala Thr Leu Glu Pro Leu Val Lys 
            260                 265                 270         


Ala Gln Leu Val Glu Glu Trp Ala Asn Ser Val Lys Lys Gln Lys Val 
        275                 280                 285             


Glu Val Tyr Leu Pro Arg Phe Thr Val Glu Gln Glu Ile Asp Leu Lys 
    290                 295                 300                 


Asp Val Leu Lys Ala Leu Gly Ile Thr Glu Ile Phe Ile Lys Asp Ala 
305                 310                 315                 320 


Asn Leu Thr Gly Leu Ser Asp Asn Lys Glu Ile Phe Leu Ser Lys Ala 
                325                 330                 335     


Ile His Lys Ser Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala 
            340                 345                 350         


Ala Val Ser Gly Met Ile Ala Ile Ser Arg Met Ala Val Leu Tyr Pro 
        355                 360                 365             


Gln Val Ile Val Asp His Pro Phe Phe Phe Leu Ile Arg Asn Arg Arg 
    370                 375                 380                 


Thr Gly Thr Ile Leu Phe Met Gly Arg Val Met His Pro Glu Thr Met 
385                 390                 395                 400 


Asn Thr Ser Gly His Asp Phe Glu Glu Leu 
                405                 410 


<210>  388
<211>  1929
<212>  DNA
<213>  Homo sapiens

<400>  388
agtttcccgg gagagacgaa agcaggaacg agagcggagc ggagcacagt ccgccgagca       60

caagctccag catcccgtca ggggttgcag gtgtgtggga ggtaagcgtg ggtccttctt      120

cggggcgtct gcactgccct ggagaaaacg tcttccaata ggaattacat caagacacag      180

ctaaaagagt ccgcgttggg ttaggaaacc ggtgcaaaac ctctcgggtg aaagatttac      240

atttttcgac tttaagggca aaaaagcaaa aggaagcttg actctgggta taaagggcgt      300

ggttagtgtt tttggtttga gttgcaccag taaaactgtt ctgggagatc tgaagattga      360

gaaaaatcct gctaattgag gacgaggtgg atgttatctg gtggatgtta taggcttgaa      420

actgttacaa tatggctttc cttggactct tctctttgct ggttctgcaa agtatggcta      480

caggggccac tttccctgag gaagccattg ctgacttgtc agtgaatatg tataatcgtc      540

ttagagccac tggtgaagat gaaaatattc tcttctctcc attgagtatt gctcttgcaa      600

tgggaatgat ggaacttggg gcccaaggat ctacccagaa agaaatccgc cactcaatgg      660

gatatgacag cctaaaaaat ggtgaagaat tttctttctt gaaggagttt tcaaacatgg      720

taactgctaa agagagccaa tatgtgatga aaattgccaa ttccttgttt gtgcaaaatg      780

gatttcatgt caatgaggag tttttgcaaa tgatgaaaaa atattttaat gcagcagtaa      840

atcatgtgga cttcagtcaa aatgtagccg tggccaacta catcaataag tgggtggaga      900

ataacacaaa caatctggtg aaagatttgg tatccccaag ggattttgat gctgccactt      960

atctggccct cattaatgct gtctatttca aggggaactg gaagtcgcag tttaggcctg     1020

aaaatactag aaccttttct ttcactaaag atgatgaaag tgaagtccaa attccaatga     1080

tgtatcagca aggagaattt tattatgggg aatttagtga tggctccaat gaagctggtg     1140

gtatctacca agtcctagaa ataccatatg aaggagatga aataagcatg atgctggtgc     1200

tgtccagaca ggaagttcct cttgctactc tggagccatt agtcaaagca cagctggttg     1260

aagaatgggc aaactctgtg aagaagcaaa aagtagaagt atacctgccc aggttcacag     1320

tggaacagga aattgattta aaagatgttt tgaaggctct tggaataact gaaattttca     1380

tcaaagatgc aaatttgaca ggcctctctg ataataagga gatttttctt tccaaagcaa     1440

ttcacaagtc cttcctagag gttaatgaag aaggctcaga agctgctgct gtctcaggaa     1500

tgattgcaat tagtaggatg gctgtgctgt atcctcaagt tattgtcgac catccatttt     1560

tctttcttat cagaaacagg agaactggta caattctatt catgggacga gtcatgcatc     1620

ctgaaacaat gaacacaagt ggacatgatt tcgaagaact ttaagttact ttatttgaat     1680

aacaaggaaa acagtaacta agcacattat gtttgcaact ggtatatatt taggatttgt     1740

gttttacagt atatcttaag ataatattta aaatagttcc agataaaaac aatatatgta     1800

aattataagt aacttgtcaa ggaatgttat cagtattaag ctaatggtcc tgttatgtca     1860

ttgtgtttgt gtgctgttgt ttaaaataaa agtacctatt gaacatgtga aaaaaaaaaa     1920

aaaaaaaaa                                                             1929


<210>  389
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Ala Phe Leu Gly Leu Phe Ser Leu Leu Val Leu Gln Ser Met Ala 
1               5                   10                  15      


Thr Gly Ala Thr Phe Pro Glu Glu Ala Ile Ala Asp Leu Ser Val Asn 
            20                  25                  30          


Met Tyr Asn Arg Leu Arg Ala Thr Gly Glu Asp Glu Asn Ile Leu Phe 
        35                  40                  45              


Ser Pro Leu Ser Ile Ala Leu Ala Met Gly Met Met Glu Leu Gly Ala 
    50                  55                  60                  


Gln Gly Ser Thr Gln Lys Glu Ile Arg His Ser Met Gly Tyr Asp Ser 
65                  70                  75                  80  


Leu Lys Asn Gly Glu Glu Phe Ser Phe Leu Lys Glu Phe Ser Asn Met 
                85                  90                  95      


Val Thr Ala Lys Glu Ser Gln Tyr Val Met Lys Ile Ala Asn Ser Leu 
            100                 105                 110         


Phe Val Gln Asn Gly Phe His Val Asn Glu Glu Phe Leu Gln Met Met 
        115                 120                 125             


Lys Lys Tyr Phe Asn Ala Ala Val Asn His Val Asp Phe Ser Gln Asn 
    130                 135                 140                 


Val Ala Val Ala Asn Tyr Ile Asn Lys Trp Val Glu Asn Asn Thr Asn 
145                 150                 155                 160 


Asn Leu Val Lys Asp Leu Val Ser Pro Arg Asp Phe Asp Ala Ala Thr 
                165                 170                 175     


Tyr Leu Ala Leu Ile Asn Ala Val Tyr Phe Lys Gly Asn Trp Lys Ser 
            180                 185                 190         


Gln Phe Arg Pro Glu Asn Thr Arg Thr Phe Ser Phe Thr Lys Asp Asp 
        195                 200                 205             


Glu Ser Glu Val Gln Ile Pro Met Met Tyr Gln Gln Gly Glu Phe Tyr 
    210                 215                 220                 


Tyr Gly Glu Phe Ser Asp Gly Ser Asn Glu Ala Gly Gly Ile Tyr Gln 
225                 230                 235                 240 


Val Leu Glu Ile Pro Tyr Glu Gly Asp Glu Ile Ser Met Met Leu Val 
                245                 250                 255     


Leu Ser Arg Gln Glu Val Pro Leu Ala Thr Leu Glu Pro Leu Val Lys 
            260                 265                 270         


Ala Gln Leu Val Glu Glu Trp Ala Asn Ser Val Lys Lys Gln Lys Val 
        275                 280                 285             


Glu Val Tyr Leu Pro Arg Phe Thr Val Glu Gln Glu Ile Asp Leu Lys 
    290                 295                 300                 


Asp Val Leu Lys Ala Leu Gly Ile Thr Glu Ile Phe Ile Lys Asp Ala 
305                 310                 315                 320 


Asn Leu Thr Gly Leu Ser Asp Asn Lys Glu Ile Phe Leu Ser Lys Ala 
                325                 330                 335     


Ile His Lys Ser Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala 
            340                 345                 350         


Ala Val Ser Gly Met Ile Ala Ile Ser Arg Met Ala Val Leu Tyr Pro 
        355                 360                 365             


Gln Val Ile Val Asp His Pro Phe Phe Phe Leu Ile Arg Asn Arg Arg 
    370                 375                 380                 


Thr Gly Thr Ile Leu Phe Met Gly Arg Val Met His Pro Glu Thr Met 
385                 390                 395                 400 


Asn Thr Ser Gly His Asp Phe Glu Glu Leu 
                405                 410 


<210>  390
<211>  1570
<212>  DNA
<213>  Homo sapiens

<400>  390
tgaggtcaga aggcggaacc gctgctggga gacggcggga tctctttcgc catggctgcc       60

gggccgatct ccgagcggaa tcaggatgcc actgtgtacg tggggggcct ggatgagaag      120

gttagtgaac cgctgctgtg ggaactgttt ctccaggctg gaccagtagt caacacccac      180

atgccaaagg atagagtcac tggccagcac caaggctatg gctttgtgga attcttgagt      240

gaggaagatg ctgactatgc cattaagatc atgaacatga tcaaactcta tgggaagcca      300

atacgggtga acaaagcatc agctcacaac aaaaacctgg atgtaggggc caacattttc      360

attgggaacc tggaccctga gattgatgag aagttgcttt atgatacttt cagcgccttt      420

ggggtcatct tacaaacccc caaaattatg cgggaccctg acacaggcaa ctccaaaggt      480

tatgccttta ttaattttgc ttcatttgat gcttcggatg cagcaattga agccatgaat      540

gggcagtacc tctgtaaccg tcctatcacc gtatcttatg ccttcaagaa ggactccaag      600

ggtgagcgcc atggctcagc agccgaacga cttctggcag ctcagaaccc gctctcccag      660

gctgatcgcc ctcatcagct gtttgcagat gcacctcctc caccctctgc tcccaatcct      720

gtggtatcat cattggggtc tgggcttcct ccaccaggca tgcctcctcc tggctccttc      780

ccacccccag tgccacctcc tggagccctc ccacctggga tacccccagc catgccccca      840

ccacctatgc ctcctggggc tgcaggacat ggccccccat cggcaggaac cccaggggca      900

ggacatcctg gtcatggaca ctcacatcct cacccattcc caccgggtgg gatgccccat      960

ccagggatgt ctcagatgca gcttgcacac catggccctc atggcttagg acatccccac     1020

gctggacccc caggctctgg gggccagcca ccgccccgac caccacctgg aatgcctcat     1080

cctggacctc ctccaatggg catgcccccc cgagggcctc cattcggatc tcccatgggt     1140

cacccaggtc ctatgcctcc gcatggtatg cgtggacctc ctccactgat gcccccccat     1200

ggatacactg gccctccacg acccccaccc tatggctacc agcgggggcc tctccctcca     1260

cccagaccca ctccccggcc accagttccc cctcgaggcc cacttcgagg ccctctccct     1320

cagtaaattc acattttcct tcctcctgtt acattttccc aatatctttt ctattccttg     1380

gaccaatcag agatgctgta gctccttggg gcaaaggtac taatcccttt cagcaccccc     1440

actccattcc cctttttaat gtaacttttt ccacaggagg tatttctttt ttatgttggt     1500

cctgagtatt ttgcaaatgc acagagaaaa taaaactaaa ctccttgtta aaaaaaaaaa     1560

aaaaaaaaaa                                                            1570


<210>  391
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr 
1               5                   10                  15      


Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu 
            20                  25                  30          


Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg 
        35                  40                  45              


Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu 
    50                  55                  60                  


Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr 
65                  70                  75                  80  


Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu 
                85                  90                  95      


Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp 
            100                 105                 110         


Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln 
        115                 120                 125             


Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr 
    130                 135                 140                 


Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu 
145                 150                 155                 160 


Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr 
                165                 170                 175     


Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu 
            180                 185                 190         


Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His 
        195                 200                 205             


Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val 
    210                 215                 220                 


Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro 
225                 230                 235                 240 


Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly 
                245                 250                 255     


Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly 
            260                 265                 270         


His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His 
        275                 280                 285             


Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro 
    290                 295                 300                 


Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly 
305                 310                 315                 320 


His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg 
                325                 330                 335     


Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro 
            340                 345                 350         


Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met 
        355                 360                 365             


Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly 
    370                 375                 380                 


Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro 
385                 390                 395                 400 


Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly 
                405                 410                 415     


Pro Leu Arg Gly Pro Leu Pro Gln 
            420                 


<210>  392
<211>  3144
<212>  DNA
<213>  Homo sapiens

<400>  392
atgtgattcc agtatggcgt ataaataaag gcgaggagaa ggcggtggtc cgccatttcg       60

tggacgccgg gtgagtgaga gagttggttg gtgttgggcc ggaggaaagc gggaagactc      120

atcggagcgt gtggatttga gccgccgcat tttttaaccc tagatctcga aatgcatcgt      180

gattcctgtc cattggactg taaggtttat gtaggcaatc ttggaaacaa tggcaacaag      240

acggaattgg aacgggcttt tggctactat ggaccactcc gaagtgtgtg ggttgctaga      300

aacccacccg gctttgcttt tgttgaattt gaagatcccc gagatgcagc tgatgcagtc      360

cgagagctag atggaagaac actatgtggc tgccgtgtaa gagtggaact gtcgaatggt      420

gaaaaaagaa gtagaaatcg tggcccacct ccctcttggg gtcgtcgccc tcgagatgat      480

tatcgtagga ggagtcctcc acctcgtcgc agatctccaa gaaggagaag cttctctcgc      540

agccggagca ggtccctttc tagagatagg agaagagaga gatcgctgtc tcgggagaga      600

aatcacaagc cgtcccgatc cttctctagg tctcgtagtc gatctaggtc aaatgaaagg      660

aaatagaaga cagtttgcaa gagaagtggt gtacaggaaa ttacttcatt tgacaggagt      720

atgtacagaa aattcaagtt ttgtttgaga cttcataagc ttggtgcatt tttaagatgt      780

tttagctgtt caaatctgtt tgtctcttga aacagtgaca caaaggtgta attctctatg      840

gtttgaaatg gatcatacga ggcatgtaat accaagaatt gttactttac aatgttccct      900

taagcaaaat tgaatttgct ttgaactttt agttatgcac agactgataa taaacctcta      960

aacctgccca gcggaagtgt gttttttttt aaatttaaat acagaaacaa ctggcaaaaa     1020

ttgaactaag atttactttt ttttccatag ctgggatata ggctgcagct atagttgaac     1080

aagcagtctt taaaaactgc tgtgaaacac aggccatcag ggaaaacgaa atgctgcact     1140

attaaattag aggtttttga aaaatccaac tctcatcctg ggcagaggtt gcctagttgg     1200

tatagaatgt taagtttcaa gaaagtttac ctttgcttta ggtcataagt tccttatttg     1260

attgctgtat atggatacat ggctgttcgt gacattcttt atgtgcaaat ttgtgatttc     1320

aaaaatgtcc tgccagttta agggtacatt gtagagccga actttgagtt actgtgcaag     1380

attttttttt catgctgtca tttgtaatat gttttgtgag aatccttggg attaaagttt     1440

tggttacaaa ttgttcttta acttgaaagc ctgtttttcc ttgcaaactc aaatctgtga     1500

gcttggtacc aagtccaggt ataacattcc tattggaagc catacttata ttttcttgta     1560

aagtgctttt gaattaataa aatattagca taattgtgta tagtcagttg aacccactgt     1620

taccattgtt cttatcccat gggaagcagt tggttacacg attcttattt tataagaaac     1680

agctgagagg cactatggat tagtcttctg aagtgaagga aatatagatg tcacctaagt     1740

gatagttaac ccattttttt tttttttagg catagaagcc agttcagggt ccataatatt     1800

tagtgaccaa cattttaaag tatagcagca acctggttct taaacacaaa gtaagttgcc     1860

cattaacaaa tggcttttat ctttagcatg aaaactttcc acaggtctaa aaattgcttc     1920

cattttataa tttgaggtgt tgcatgggaa ttctaagctg atccatcatg atgtaaaagt     1980

tcacaatatg gttcaaatgt aacagtgcag aattgaatat ggaggcatgc ataaccttcc     2040

tcttagaaaa tggcaggtgt tgtaatttca aatttttgtg caattagatt aaatcataat     2100

gcaacagtct tgtggcttag tttccttaaa tatgctctta agatagtttt ggattatgcg     2160

gtattgactg tcttaaatat gaaagataag tcattgcatt aagagttcaa gctaaatgga     2220

tacattaaga tacagttcct aaacaaatta tttatttcca ccttttacac aaatcttggg     2280

agaattggtg tcaggaaggt tcagccttaa agttaagcat gttcaagaaa gacacttttc     2340

agacagcctg tttatttact gagagctctg gcattgggca ttttgtcttt agtattctca     2400

catagcctac aacctgttcc tgttaggaac aagccaagat agctaagaag ttacggaagc     2460

catgcaatat gtcaattaca ttgcttttta taaatggaca acttatgtgg gcatttttgg     2520

gcagtatatg acttccttgc aggctcttaa gttggaaggg tttctgtaaa aaggacagtt     2580

acgggtataa tatggctaag agaaataata cagaacctga aataaaagta acttcaccag     2640

ggagttatcc tgacttaggt gacatacagt cccagttggc agttacttta accaggagcc     2700

ctagcataac ctcaagactc ttagaaactt tagaacatgg aaattgttaa aagctttgaa     2760

ttgcacattt agattgtggc tattaggaat ttttaaagtt gtaattccta aaataacagg     2820

tcacactaac cggtcttgtc catattcagg gttgagtgta aaaatgaaag gaatcacaaa     2880

actgaactta gacctgtggt ttaaggatca aggtgttcac tagaagtcac tgttactaat     2940

acttgatgac aatgtaaaga aacattaagg attatatttg attgttttca aagacactgg     3000

ctggatgtgg tggctcacac ttgtaattcc tagcactttg ggaggctagg gcgggtggga     3060

ggatctcttg aagccaggag ttggagacca gtctgcccaa catggcaaga ttcacatttc     3120

tattaaaagg aatatttagt ttga                                            3144


<210>  393
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  393

Met His Arg Asp Ser Cys Pro Leu Asp Cys Lys Val Tyr Val Gly Asn 
1               5                   10                  15      


Leu Gly Asn Asn Gly Asn Lys Thr Glu Leu Glu Arg Ala Phe Gly Tyr 
            20                  25                  30          


Tyr Gly Pro Leu Arg Ser Val Trp Val Ala Arg Asn Pro Pro Gly Phe 
        35                  40                  45              


Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Ala Asp Ala Val Arg 
    50                  55                  60                  


Glu Leu Asp Gly Arg Thr Leu Cys Gly Cys Arg Val Arg Val Glu Leu 
65                  70                  75                  80  


Ser Asn Gly Glu Lys Arg Ser Arg Asn Arg Gly Pro Pro Pro Ser Trp 
                85                  90                  95      


Gly Arg Arg Pro Arg Asp Asp Tyr Arg Arg Arg Ser Pro Pro Pro Arg 
            100                 105                 110         


Arg Arg Ser Pro Arg Arg Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser 
        115                 120                 125             


Leu Ser Arg Asp Arg Arg Arg Glu Arg Ser Leu Ser Arg Glu Arg Asn 
    130                 135                 140                 


His Lys Pro Ser Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser Arg Ser 
145                 150                 155                 160 


Asn Glu Arg Lys 
                


<210>  394
<211>  2991
<212>  DNA
<213>  Homo sapiens

<400>  394
acaggcgcgc gcgaggacgc gctccgggga cgcgcgagga cgccgtggcg ggagaagcgt       60

ttccggtggc ggcggaggct gcactgagcg ggacctgcga gcagcgcggg cggcagcccg      120

ggggaagcgt ccgggaccat gtctggagaa ctaccaccaa acattaacat caaggaacct      180

cgatgggatc aaagcacttt cattggacga gccaatcatt tcttcactgt aactgacccc      240

aggaacattc tgttaaccaa cgaacaactc gagagtgcga gaaaaatagt acatgattac      300

aggcaaggaa ttgttcctcc tggtcttaca gaaaatgaat tgtggagagc aaagtacatc      360

tatgattcag cttttcatcc tgacactggt gagaagatga ttttgatagg aagaatgtca      420

gcccaggttc ccatgaacat gaccatcaca ggttgtatga tgacgtttta caggactacg      480

ccggctgtgc tgttctggca gtggattaac cagtccttca atgccgtcgt caattacacc      540

aacagaagtg gagacgcacc cctcactgtc aatgagttgg gaacagctta cgtttctgca      600

acaactggtg ccgtagcaac agctctagga ctcaatgcat tgaccaagca tgtctcacca      660

ctgataggac gttttgttcc ctttgctgcc gtagctgctg ctaattgcat taatattcca      720

ttaatgaggc aaagggaact caaagttggc attcccgtca cggatgagaa tgggaaccgc      780

ttgggggagt cggcgaacgc tgcgaaacaa gccatcacgc aagttgtcgt gtccaggatt      840

ctcatggcag cccctggcat ggccatccct ccattcatta tgaacacttt ggaaaagaaa      900

gcctttttga agaggttccc atggatgagt gcacccattc aagttgggtt agttggcttc      960

tgtttggtgt ttgctacacc cctgtgttgt gccctgtttc ctcagaaaag ttccatgtct     1020

gtgacaagct tggaggccga gttgcaagct aagatccaag agagccatcc tgaattgcga     1080

cgcgtgtact tcaataaggg attgtaaagc agggaggaaa cctctgcagc tcattctgcc     1140

actgcaaagc tggtgtagcc atgctggtga gaaaaatcct gttcaacctg ggttctccca     1200

gttacggaaa ccttttaaag atccacatta gccttttaga ataaagctgc tactttaaca     1260

gagcacctgg cgtgggccaa gtgcctgata ctcccttaca ctgaatcatg ttatgattta     1320

tagaaatacc tttcctgtag cttttatagt cattgttttt caaagacgat ataccagccc     1380

tcacccaggt tttaaaaaag cactggtagg catagaatag gtgctcagta tatggtcagt     1440

aaatgttcta ttgattatca atcagtgaaa aaagaaatct gtttaaaata ctgaattttc     1500

atctcactcc cattgcaaat caaggagatc tcagcagtga actgggaaaa tacaaaagct     1560

ctgggctaat ctataaaaac ttaccctgaa atattaaggg cagtttgctt ctagtttggg     1620

gattgcgcta gcccaatgaa ggtgatgaag cttttggatt tggagggtaa aagctccttc     1680

acaccccttc caaaagtcag tcacagacca ctgcaacatg ccttccctgc tggatcatta     1740

tatacattca gattgtgagt ggattgcctt ggttgacttt taatttattg ttttttgttc     1800

ttataaagat gataatctta ccttgcagtt attgacttta tattcaatta tttacatcaa     1860

ataatgaaat aactgaaatg tacaaatgtc aaattttgga agtatattca ataccaatgc     1920

tgtatgagtg ggctgaatcc agttcattgt tttttttttg gtaagaagtg agactacagt     1980

tccagctacc tacatgtctt ttcttgtcat ccttatagat ctctttggct ttcagaaaga     2040

tacagtgata atgtgtgtat gaatcagtca caatgaattt tacttgaata ttgtatgttg     2100

cattccactt catttgaaaa taatgaaacc atgtaccact gtttacatca tctgtagtga     2160

tttcatagat aatatattta atatgacaga ttatgtttca actctgtaga tgtttaacgt     2220

catagacagt tggccctctg tatccgtgag ctctatatct gtgaattcaa ccaagtttgg     2280

atggaaaatt tttttttttt tttttttttt gagacggagt ctcgctctgt cacccaggct     2340

ggagtgcagt ggcgtagtct cggctcactg caagctccgc ctcccgggtt cacgccgttc     2400

tcctgcctca gcctctctga gaagctggga ctacaggcgc ccgccaccac gcccggctaa     2460

tttttttgta tttttagtag agacggggtt tcactgtggt ctcgatctcc tgacctcgtg     2520

atccgcccgc cttggcctcc caaggtgctg ggattacaag cgtgagccac cgcacccggc     2580

ctgaaaatat tttctaaaaa gataaaaaat atacataacg atgaaaaata atacaaattt     2640

aaaaaccaat acagtataac aactatttac atagtgctta cattgtatta ggtgttataa     2700

gcaatctaga gatgatttag caagtataca ggaggatgtg cctaggttat atgcaaatac     2760

tgtgccattt tatatcagga acttgagcat ctgcagatat tggtatcgga gggcggtcct     2820

ggaaccaagc atccacggat actgaggggt gacatttcat gaagtgtaga tcattgtatt     2880

cagagattgt aaatgaaaaa aatatagaaa ctatttagtt ttggtagatt ttttttctga     2940

caatgtgacc agactgaatt tcctcataaa gaaaaaatgg cgtgccttgt g              2991


<210>  395
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Ser Gly Glu Leu Pro Pro Asn Ile Asn Ile Lys Glu Pro Arg Trp 
1               5                   10                  15      


Asp Gln Ser Thr Phe Ile Gly Arg Ala Asn His Phe Phe Thr Val Thr 
            20                  25                  30          


Asp Pro Arg Asn Ile Leu Leu Thr Asn Glu Gln Leu Glu Ser Ala Arg 
        35                  40                  45              


Lys Ile Val His Asp Tyr Arg Gln Gly Ile Val Pro Pro Gly Leu Thr 
    50                  55                  60                  


Glu Asn Glu Leu Trp Arg Ala Lys Tyr Ile Tyr Asp Ser Ala Phe His 
65                  70                  75                  80  


Pro Asp Thr Gly Glu Lys Met Ile Leu Ile Gly Arg Met Ser Ala Gln 
                85                  90                  95      


Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Met Thr Phe Tyr Arg 
            100                 105                 110         


Thr Thr Pro Ala Val Leu Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn 
        115                 120                 125             


Ala Val Val Asn Tyr Thr Asn Arg Ser Gly Asp Ala Pro Leu Thr Val 
    130                 135                 140                 


Asn Glu Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala 
145                 150                 155                 160 


Thr Ala Leu Gly Leu Asn Ala Leu Thr Lys His Val Ser Pro Leu Ile 
                165                 170                 175     


Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn 
            180                 185                 190         


Ile Pro Leu Met Arg Gln Arg Glu Leu Lys Val Gly Ile Pro Val Thr 
        195                 200                 205             


Asp Glu Asn Gly Asn Arg Leu Gly Glu Ser Ala Asn Ala Ala Lys Gln 
    210                 215                 220                 


Ala Ile Thr Gln Val Val Val Ser Arg Ile Leu Met Ala Ala Pro Gly 
225                 230                 235                 240 


Met Ala Ile Pro Pro Phe Ile Met Asn Thr Leu Glu Lys Lys Ala Phe 
                245                 250                 255     


Leu Lys Arg Phe Pro Trp Met Ser Ala Pro Ile Gln Val Gly Leu Val 
            260                 265                 270         


Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro 
        275                 280                 285             


Gln Lys Ser Ser Met Ser Val Thr Ser Leu Glu Ala Glu Leu Gln Ala 
    290                 295                 300                 


Lys Ile Gln Glu Ser His Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys 
305                 310                 315                 320 


Gly Leu 
        


<210>  396
<211>  3385
<212>  DNA
<213>  Homo sapiens

<400>  396
ggtttcaaat tggccctttg gcctctggag caaattcaaa tgtaactctt ccccaacccc       60

ccttctcttc ttccagatta attaaaagaa gaatgaacta taatccttga agataactgg      120

gcaatttttt aagtcggagg ctgttcttac tggtgtgagg atttacacac gtcttcagtt      180

tttcagcaca gaccagcaga ccatcatttt tagaggaaat actccctctg ccctcctttt      240

tggtttcctt ggtggtaaag attaaatttg gttgcatcat tttgacttgt gtttgagtct      300

agattttatg gcacaaggaa tggcataaac ttttcatgtg ttttggttaa aacaaaccag      360

accattgcat tgaccctgga catctttaat tgagaaattg gtaactttat tttaatatgt      420

atatctgaag aattcaagaa aacaaaggca tcctcagagg tgtgcctctt ttctttatta      480

ttagaggcaa aacgaacaat tttataggat ttgtagtgaa attataccag attataagga      540

gaaccaaaac taagtcgcaa aatttattaa tttaaggggc tctcgctttg aaagtttgag      600

agtaagttac gataggcatt tgtatccatt cattactttc ctcttttcaa ataagcaact      660

aaatagaaat gctaatctca gacttaatta tttaacagaa gagtgtacca tggaaaacct      720

ccagacaaat ttctccttgg ttcagggctc aactaaaaaa ctgaatggga tgggagatga      780

tggcagcccc ccagcgaaaa aaatgataac ggacattcat gcaaatggaa aaacgataaa      840

caaggtgcca acagttaaga aggaacactt ggatgactat ggagaagcac cagtggaaac      900

tgatggagag catgttaagc gaacctgtac ttctgttcct gaaactttgc atttaaatcc      960

cagtttgaaa cacacattgg cacaattcca tttaagtagt cagagctcgc tgggtggacc     1020

agcagcattt tctgctcggc attcccaaga aagcatgtcg cctactgtat ttctgcctct     1080

tccatcacct caggttcttc ctggcccatt gctcatccct tcagatagct ccacagaact     1140

cactcagact gtgttggaag gggaatctat ttcttgtttt caagttggag gagaaaagag     1200

actctgtttg ccccaagtct taaattctgt tctccgagaa tttacactcc agcaaataaa     1260

tacagtgtgt gatgaactgt acatatattg ttcaaggtgt acttcagacc agcttcatat     1320

cttaaaggta ctgggcatac ttccattcaa tgccccatcc tgtgggctga ttacattaac     1380

tgatgcacaa agattatgta atgctttatt gcggccacga acttttcctc aaaatggtag     1440

cgtacttcct gctaaaagct cattggccca gttaaaggaa actggcagtg cctttgaagt     1500

ggagcatgaa tgcctaggca aatgtcaggg tttatttgca ccccagtttt atgttcagcc     1560

tgatgctccg tgtattcaat gtctggagtg ttgtggaatg tttgcacccc agacgtttgt     1620

gatgcattct cacagatcac ctgacaaaag aacttgccac tggggctttg aatcagctaa     1680

atggcattgc tatcttcatg tgaaccaaaa atacttagga acacctgaag aaaagaaact     1740

gaagataatt ttagaagaaa tgaaggagaa gtttagcatg agaagtggaa agagaaatca     1800

atccaagaca gatgcaccat caggaatgga attacagtca tggtatcctg ttataaagca     1860

ggaaggtgac catgtttctc agacacattc atttttacac cccagctact acttatacat     1920

gtgtgataaa gtggttgccc caaatgtgtc acttacttct gctgtatccc agtctaaaga     1980

gctcacaaag acagaggcaa atgcatcaat ctcaaataat tctacaagta aaaggaaatc     2040

tgagtctgcc acttgcaact tagtcagaga cataaacaaa gtgggaattg gccttgttgc     2100

tgccgcttca tctccgcttc ttgtgaaaga tgtcatttgt gaggatgata agggaaaaat     2160

catggaagaa gtaatgagaa cttatttaaa acaacaggaa aaactaaact tgattttgca     2220

aaagaagcaa caacttcaga tggaagtaaa aatgttgagt agttcaaaat ctatgaagga     2280

actcactgaa gaacagcaga atttacagaa agagcttgaa tctttgcaga atgaacatgc     2340

tcaaagaatg gaagaatttt atgttgaaca gaaagactta gagaaaaaat tggagcagat     2400

aatgaagcaa aaatgtacct gtgactcaaa tttagaaaaa gacaaagagg ctgaatatgc     2460

aggacagttg gcagaactga ggcagagatt ggaccatgct gaggccgata ggcaagaact     2520

ccaagatgaa ctcagacagg aacgggaagc aagacagaag ttagagatga tgataaaaga     2580

gctaaagctg caaattctga aatcatcaaa gactgctaaa gaatagaaac tgttaaagag     2640

attcatctgt gtattactga caaggttttt tttgtttgtt gcttgctttg gtaattgaat     2700

tctgaagaat ttatctgcat gacgataact aggcattcta tccatttgta gatcagagaa     2760

agtgaagaga ttatatatta gtacttaaat ttttacattt tccaaatgaa tgaaaatgta     2820

tgtttctttg tactttttta aaaaaatcag cttagtaaca atactatatg gtttcaacta     2880

gtaggtaatc tgcttatatt tctaatgcaa acttaacaat tgtgtacttt ttaaaagctg     2940

caatatgtgt tggaaaatag ctgtggtcaa ttttgttatc catatttcag actcaatttt     3000

agatacaatg gtggctttat attttaagta tatagagcta ctcaaggagt tgaatctccc     3060

cttttctcat taacacaatt tttctaagtt gatatggtgt actcattaac atacaccaaa     3120

tttactttta ctttgttcag attgtggaat gaatttccac cagttctctt ctttttaatg     3180

tgtaccctag gaggaatttt actgaggtta tagcataccc catgagcaca gtggggaaga     3240

agaatgtgtt gttatgtgct gctgctaaac agaagcagca gttgtaattt gtttttcagt     3300

ttaaatgtgg ttatagttag attttttttt aagcagcaac ttttcaaaaa taaaatgtga     3360

taatttctga aaaaaaaaaa aaaaa                                           3385


<210>  397
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Asn Ala 
            420                 425                 430         


Ser Ile Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr 
        435                 440                 445             


Cys Asn Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala 
    450                 455                 460                 


Ala Ala Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp 
465                 470                 475                 480 


Lys Gly Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln 
                485                 490                 495     


Glu Lys Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu 
            500                 505                 510         


Val Lys Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu 
        515                 520                 525             


Gln Gln Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala 
    530                 535                 540                 


Gln Arg Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys 
545                 550                 555                 560 


Leu Glu Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu 
                565                 570                 575     


Lys Asp Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln 
            580                 585                 590         


Arg Leu Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu 
        595                 600                 605             


Arg Gln Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu 
    610                 615                 620                 


Leu Lys Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
625                 630                 635             


<210>  398
<211>  3035
<212>  DNA
<213>  Homo sapiens

<400>  398
gatgtgtgtg gggttcggag ccgcgccggc acagccgaag ggagcgggcg agcggcgacg       60

gcggcggcgg cgggcacaga ttaattaaaa gaagaatgaa ctataatcct tgaagataac      120

tgggcaattt tttaagtcgg aggctgttct tactggtgtg aggatttaca cacgtcttca      180

gtttttcagc acagaccagc agaccatcat ttttagagga aatactccct ctgccctcct      240

ttttggtttc cttggtgggc tcaactaaaa aactgaatgg gatgggagat gatggcagcc      300

ccccagcgaa aaaaatgata acggacattc atgcaaatgg aaaaacgata aacaaggtgc      360

caacagttaa gaaggaacac ttggatgact atggagaagc accagtggaa actgatggag      420

agcatgttaa gcgaacctgt acttctgttc ctgaaacttt gcatttaaat cccagtttga      480

aacacacatt ggcacaattc catttaagta gtcagagctc gctgggtgga ccagcagcat      540

tttctgctcg gcattcccaa gaaagcatgt cgcctactgt atttctgcct cttccatcac      600

ctcaggttct tcctggccca ttgctcatcc cttcagatag ctccacagaa ctcactcaga      660

ctgtgttgga aggggaatct atttcttgtt ttcaagttgg aggagaaaag agactctgtt      720

tgccccaagt cttaaattct gttctccgag aatttacact ccagcaaata aatacagtgt      780

gtgatgaact gtacatatat tgttcaaggt gtacttcaga ccagcttcat atcttaaagg      840

tactgggcat acttccattc aatgccccat cctgtgggct gattacatta actgatgcac      900

aaagattatg taatgcttta ttgcggccac gaacttttcc tcaaaatggt agcgtacttc      960

ctgctaaaag ctcattggcc cagttaaagg aaactggcag tgcctttgaa gtggagcatg     1020

aatgcctagg caaatgtcag ggtttatttg caccccagtt ttatgttcag cctgatgctc     1080

cgtgtattca atgtctggag tgttgtggaa tgtttgcacc ccagacgttt gtgatgcatt     1140

ctcacagatc acctgacaaa agaacttgcc actggggctt tgaatcagct aaatggcatt     1200

gctatcttca tgtgaaccaa aaatacttag gaacacctga agaaaagaaa ctgaagataa     1260

ttttagaaga aatgaaggag aagtttagca tgagaagtgg aaagagaaat caatccaaga     1320

cagatgcacc atcaggaatg gaattacagt catggtatcc tgttataaag caggaaggtg     1380

accatgtttc tcagacacat tcatttttac accccagcta ctacttatac atgtgtgata     1440

aagtggttgc cccaaatgtg tcacttactt ctgctgtatc ccagtctaaa gagctcacaa     1500

agacagaggc aagtaagtcc atatcaagac agtcagagaa ggctcacagt agtggtaaac     1560

ttcaaaaaac agtgtcttat ccagatgtct cacttgagga acaggagaaa atggatttaa     1620

aaacaagtag agaattatgt agccgtttag atgcatcaat ctcaaataat tctacaagta     1680

aaaggaaatc tgagtctgcc acttgcaact tagtcagaga cataaacaaa gtgggaattg     1740

gccttgttgc tgccgcttca tctccgcttc ttgtgaaaga tgtcatttgt gaggatgata     1800

agggaaaaat catggaagaa gtaatgagaa cttatttaaa acaacaggaa aaactaaact     1860

tgattttgca aaagaagcaa caacttcaga tggaagtaaa aatgttgagt agttcaaaat     1920

ctatgaagga actcactgaa gaacagcaga atttacagaa agagcttgaa tctttgcaga     1980

atgaacatgc tcaaagaatg gaagaatttt atgttgaaca gaaagactta gagaaaaaat     2040

tggagcagat aatgaagcaa aaatgtacct gtgactcaaa tttagaaaaa gacaaagagg     2100

ctgaatatgc aggacagttg gcagaactga ggcagagatt ggaccatgct gaggccgata     2160

ggcaagaact ccaagatgaa ctcagacagg aacgggaagc aagacagaag ttagagatga     2220

tgataaaaga gctaaagctg caaattctga aatcatcaaa gactgctaaa gaatagaaac     2280

tgttaaagag attcatctgt gtattactga caaggttttt tttgtttgtt gcttgctttg     2340

gtaattgaat tctgaagaat ttatctgcat gacgataact aggcattcta tccatttgta     2400

gatcagagaa agtgaagaga ttatatatta gtacttaaat ttttacattt tccaaatgaa     2460

tgaaaatgta tgtttctttg tactttttta aaaaaatcag cttagtaaca atactatatg     2520

gtttcaacta gtaggtaatc tgcttatatt tctaatgcaa acttaacaat tgtgtacttt     2580

ttaaaagctg caatatgtgt tggaaaatag ctgtggtcaa ttttgttatc catatttcag     2640

actcaatttt agatacaatg gtggctttat attttaagta tatagagcta ctcaaggagt     2700

tgaatctccc cttttctcat taacacaatt tttctaagtt gatatggtgt actcattaac     2760

atacaccaaa tttactttta ctttgttcag attgtggaat gaatttccac cagttctctt     2820

ctttttaatg tgtaccctag gaggaatttt actgaggtta tagcataccc catgagcaca     2880

gtggggaaga agaatgtgtt gttatgtgct gctgctaaac agaagcagca gttgtaattt     2940

gtttttcagt ttaaatgtgg ttatagttag attttttttt aagcagcaac ttttcaaaaa     3000

taaaatgtga taatttctga aaaaaaaaaa aaaaa                                3035


<210>  399
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met Ile Thr Asp Ile 
1               5                   10                  15      


His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr Val Lys Lys Glu 
            20                  25                  30          


His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr Asp Gly Glu His 
        35                  40                  45              


Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu His Leu Asn Pro 
    50                  55                  60                  


Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser Ser Gln Ser Ser 
65                  70                  75                  80  


Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser Gln Glu Ser Met 
                85                  90                  95      


Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln Val Leu Pro Gly 
            100                 105                 110         


Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu Thr Gln Thr Val 
        115                 120                 125             


Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly Gly Glu Lys Arg 
    130                 135                 140                 


Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg Glu Phe Thr Leu 
145                 150                 155                 160 


Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile Tyr Cys Ser Arg 
                165                 170                 175     


Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu Gly Ile Leu Pro 
            180                 185                 190         


Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr Asp Ala Gln Arg 
        195                 200                 205             


Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro Gln Asn Gly Ser 
    210                 215                 220                 


Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys Glu Thr Gly Ser 
225                 230                 235                 240 


Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys Gln Gly Leu Phe 
                245                 250                 255     


Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys Ile Gln Cys Leu 
            260                 265                 270         


Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val Met His Ser His 
        275                 280                 285             


Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe Glu Ser Ala Lys 
    290                 295                 300                 


Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu Gly Thr Pro Glu 
305                 310                 315                 320 


Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys Glu Lys Phe Ser 
                325                 330                 335     


Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp Ala Pro Ser Gly 
            340                 345                 350         


Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln Glu Gly Asp His 
        355                 360                 365             


Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr Tyr Leu Tyr Met 
    370                 375                 380                 


Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr Ser Ala Val Ser 
385                 390                 395                 400 


Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys Ser Ile Ser Arg 
                405                 410                 415     


Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln Lys Thr Val Ser 
            420                 425                 430         


Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met Asp Leu Lys Thr 
        435                 440                 445             


Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile Ser Asn Asn Ser 
    450                 455                 460                 


Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn Leu Val Arg Asp 
465                 470                 475                 480 


Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala Ser Ser Pro Leu 
                485                 490                 495     


Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly Lys Ile Met Glu 
            500                 505                 510         


Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys Leu Asn Leu Ile 
        515                 520                 525             


Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys Met Leu Ser Ser 
    530                 535                 540                 


Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln Asn Leu Gln Lys 
545                 550                 555                 560 


Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg Met Glu Glu Phe 
                565                 570                 575     


Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu Gln Ile Met Lys 
            580                 585                 590         


Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp Lys Glu Ala Glu 
        595                 600                 605             


Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu Asp His Ala Glu 
    610                 615                 620                 


Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln Glu Arg Glu Ala 
625                 630                 635                 640 


Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys Leu Gln Ile Leu 
                645                 650                 655     


Lys Ser Ser Lys Thr Ala Lys Glu 
            660                 


<210>  400
<211>  3526
<212>  DNA
<213>  Homo sapiens

<400>  400
gatgtgtgtg gggttcggag ccgcgccggc acagccgaag ggagcgggcg agcggcgacg       60

gcggcggcgg cgggcacaga ttaattaaaa gaagaatgaa ctataatcct tgaagataac      120

tgggcaattt tttaagtcgg aggctgttct tactggtgtg aggatttaca cacgtcttca      180

gtttttcagc acagaccagc agaccatcat ttttagagga aatactccct ctgccctcct      240

ttttggtttc cttggtggta aagattaaat ttggttgcat cattttgact tgtgtttgag      300

tctagatttt atggcacaag gaatggcata aacttttcat gtgttttggt taaaacaaac      360

cagaccattg cattgaccct ggacatcttt aattgagaaa ttggtaactt tattttaata      420

tgtatatctg aagaattcaa gaaaacaaag gcatcctcag aggtgtgcct cttttcttta      480

ttattagagg caaaacgaac aattttatag gatttgtagt gaaattatac cagattataa      540

ggagaaccaa aactaagtcg caaaatttat taatttaagg ggctctcgct ttgaaagttt      600

gagagtaagt tacgataggc atttgtatcc attcattact ttcctctttt caaataagca      660

actaaataga aatgctaatc tcagacttaa ttatttaaca gaagagtgta ccatggaaaa      720

cctccagaca aatttctcct tggttcaggg ctcaactaaa aaactgaatg ggatgggaga      780

tgatggcagc cccccagcga aaaaaatgat aacggacatt catgcaaatg gaaaaacgat      840

aaacaaggtg ccaacagtta agaaggaaca cttggatgac tatggagaag caccagtgga      900

aactgatgga gagcatgtta agcgaacctg tacttctgtt cctgaaactt tgcatttaaa      960

tcccagtttg aaacacacat tggcacaatt ccatttaagt agtcagagct cgctgggtgg     1020

accagcagca ttttctgctc ggcattccca agaaagcatg tcgcctactg tatttctgcc     1080

tcttccatca cctcaggttc ttcctggccc attgctcatc ccttcagata gctccacaga     1140

actcactcag actgtgttgg aaggggaatc tatttcttgt tttcaagttg gaggagaaaa     1200

gagactctgt ttgccccaag tcttaaattc tgttctccga gaatttacac tccagcaaat     1260

aaatacagtg tgtgatgaac tgtacatata ttgttcaagg tgtacttcag accagcttca     1320

tatcttaaag gtactgggca tacttccatt caatgcccca tcctgtgggc tgattacatt     1380

aactgatgca caaagattat gtaatgcttt attgcggcca cgaacttttc ctcaaaatgg     1440

tagcgtactt cctgctaaaa gctcattggc ccagttaaag gaaactggca gtgcctttga     1500

agtggagcat gaatgcctag gcaaatgtca gggtttattt gcaccccagt tttatgttca     1560

gcctgatgct ccgtgtattc aatgtctgga gtgttgtgga atgtttgcac cccagacgtt     1620

tgtgatgcat tctcacagat cacctgacaa aagaacttgc cactggggct ttgaatcagc     1680

taaatggcat tgctatcttc atgtgaacca aaaatactta ggaacacctg aagaaaagaa     1740

actgaagata attttagaag aaatgaagga gaagtttagc atgagaagtg gaaagagaaa     1800

tcaatccaag acagatgcac catcaggaat ggaattacag tcatggtatc ctgttataaa     1860

gcaggaaggt gaccatgttt ctcagacaca ttcattttta caccccagct actacttata     1920

catgtgtgat aaagtggttg ccccaaatgt gtcacttact tctgctgtat cccagtctaa     1980

agagctcaca aagacagagg caagtaagtc catatcaaga cagtcagaga aggctcacag     2040

tagtggtaaa cttcaaaaaa cagtgtctta tccagatgtc tcacttgagg aacaggagaa     2100

aatggattta aaaacaagta gagaattatg tagccgttta gatgcatcaa tctcaaataa     2160

ttctacaagt aaaaggaaat ctgagtctgc cacttgcaac ttagtcagag acataaacaa     2220

agtgggaatt ggccttgttg ctgccgcttc atctccgctt cttgtgaaag atgtcatttg     2280

tgaggatgat aagggaaaaa tcatggaaga agtaatgaga acttatttaa aacaacagga     2340

aaaactaaac ttgattttgc aaaagaagca acaacttcag atggaagtaa aaatgttgag     2400

tagttcaaaa tctatgaagg aactcactga agaacagcag aatttacaga aagagcttga     2460

atctttgcag aatgaacatg ctcaaagaat ggaagaattt tatgttgaac agaaagactt     2520

agagaaaaaa ttggagcaga taatgaagca aaaatgtacc tgtgactcaa atttagaaaa     2580

agacaaagag gctgaatatg caggacagtt ggcagaactg aggcagagat tggaccatgc     2640

tgaggccgat aggcaagaac tccaagatga actcagacag gaacgggaag caagacagaa     2700

gttagagatg atgataaaag agctaaagct gcaaattctg aaatcatcaa agactgctaa     2760

agaatagaaa ctgttaaaga gattcatctg tgtattactg acaaggtttt ttttgtttgt     2820

tgcttgcttt ggtaattgaa ttctgaagaa tttatctgca tgacgataac taggcattct     2880

atccatttgt agatcagaga aagtgaagag attatatatt agtacttaaa tttttacatt     2940

ttccaaatga atgaaaatgt atgtttcttt gtactttttt aaaaaaatca gcttagtaac     3000

aatactatat ggtttcaact agtaggtaat ctgcttatat ttctaatgca aacttaacaa     3060

ttgtgtactt tttaaaagct gcaatatgtg ttggaaaata gctgtggtca attttgttat     3120

ccatatttca gactcaattt tagatacaat ggtggcttta tattttaagt atatagagct     3180

actcaaggag ttgaatctcc ccttttctca ttaacacaat ttttctaagt tgatatggtg     3240

tactcattaa catacaccaa atttactttt actttgttca gattgtggaa tgaatttcca     3300

ccagttctct tctttttaat gtgtacccta ggaggaattt tactgaggtt atagcatacc     3360

ccatgagcac agtggggaag aagaatgtgt tgttatgtgc tgctgctaaa cagaagcagc     3420

agttgtaatt tgtttttcag tttaaatgtg gttatagtta gatttttttt taagcagcaa     3480

cttttcaaaa ataaaatgtg ataatttctg aaaaaaaaaa aaaaaa                    3526


<210>  401
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys 
            420                 425                 430         


Ser Ile Ser Arg Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln 
        435                 440                 445             


Lys Thr Val Ser Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met 
    450                 455                 460                 


Asp Leu Lys Thr Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile 
465                 470                 475                 480 


Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn 
                485                 490                 495     


Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala 
            500                 505                 510         


Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly 
        515                 520                 525             


Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys 
    530                 535                 540                 


Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys 
545                 550                 555                 560 


Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln 
                565                 570                 575     


Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg 
            580                 585                 590         


Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu 
        595                 600                 605             


Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp 
    610                 615                 620                 


Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu 
625                 630                 635                 640 


Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln 
                645                 650                 655     


Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys 
            660                 665                 670         


Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
        675                 680                 


<210>  402
<211>  3433
<212>  DNA
<213>  Homo sapiens

<400>  402
ttgccggcgt ctccgagccc gcgctcccag ctgcagagcg cctggcttgc ctcccgcgcg       60

gtcaccgccg gcccgccgcc cccgctcccg cccgcgcccg gagcccctgc ctcgcgcccg      120

atggtgagca gtgtgttgtg ccgctgtgtg gcctccccgc cgccggacgc cgccgccacc      180

gccgcctctt cgtctgcctc atcgccggcg tccgtggggg acccctgcgg cggcgctatc      240

tgcgggggcc cggaccaccg gctgcgcctg tggagactct ttcagacgct cgacgtcaac      300

cgggacggcg gcctgtgtgt caacgacctg gcggtggggc tgcggcgcct gggactgcac      360

cgcaccgagg gcgagctcca gaaaattgta caagctggag ataaggacct tgatgggcag      420

ctagactttg aagaatttgt ccattatctc caagatcatg agaagaagct gaggctggtg      480

tttaagagtt tggacaaaaa gaatgatgga cgcattgacg cgcaggagat catgcagtcc      540

ctgcgggact tgggagtcaa gatatctgaa cagcaggcag aaaaaattct caagagcatg      600

gataaaaacg gcacgatgac catcgactgg aacgagtgga gagactacca cctcctccac      660

cccgtggaaa acatccccga gatcatcctc tactggaagc attccacgat ctttgatgtg      720

ggtgagaatc taacggtccc ggatgagttc acagtggagg agaggcagac ggggatgtgg      780

tggagacacc tggtggcagg aggtggggca ggggccgtat ccagaacctg cacggccccc      840

ctggacaggc tcaaggtgct catgcaggtc catgcctccc gcagcaacaa catgggcatc      900

gttggtggct tcactcagat gattcgagaa ggaggggcca ggtcactctg gcggggcaat      960

ggcatcaacg tcctcaaaat tgcccccgaa tcagccatca aattcatggc ctatgagcag     1020

atcaagcgcc ttgttggtag tgaccaggag actctgagga ttcacgagag gcttgtggca     1080

gggtccttgg caggggccat cgcccagagc agcatctacc caatggaggt cctgaagacc     1140

cggatggcgc tgcggaagac aggccagtac tcaggaatgc tggactgcgc caggaggatc     1200

ctggccagag agggggtggc cgccttctac aaaggctatg tccccaacat gctgggcatc     1260

atcccctatg ccggcatcga ccttgcagtc tacgagacgc tcaagaatgc ctggctgcag     1320

cactatgcag tgaacagcgc ggaccccggc gtgtttgtgc tcctggcctg tggcaccatg     1380

tccagtacct gtggccagct ggccagctac cccctggccc tagtcaggac ccggatgcag     1440

gcgcaagcct ctattgaggg cgctccggag gtgaccatga gcagcctctt caaacatatc     1500

ctgcggaccg agggggcctt cgggctgtac agggggctgg cccccaactt catgaaggtc     1560

atcccagctg tgagcatcag ctacgtggtc tacgagaacc tgaagatcac cctgggcgtg     1620

cagtcgcggt gacgggggga gggccgcccg gcagtggact cgctgatcct gggccgcagc     1680

ctggggtgtg cagccatctc attctgtgaa tgtgccaaca ctaagctgtc tcgagccaag     1740

ctgtgaaaac cctagacgca cccgcaggga gggtggggag agctggcagg cccagggctt     1800

gtcctgctga ccccagcaga ccctcctgtt ggttccagcg aagaccacag gcattcctta     1860

gggtccaggg tcagcaggct ccgggctcac atgtgtaagg acaggacatt ttctgcagtg     1920

cctgccaata gcgagcttgg agcctggagg ccggcttagt tcttccattt cacccttgca     1980

gccagctgtt ggccacggcc cctgccctct ggtctgccgt gcatctccct gtgccctctt     2040

gctgcctgcc tgtctgctga ggtaaggtgg gaggagggct acagcccaca tcccaccccc     2100

tcgtccaatc ccataatcca tgatgaaagg tgaggtcacg tggcctccca ggcctgactt     2160

cccaacctac agcattgacg ccaacttggc tgtgaaggaa gaggaaagga tctggccttg     2220

tggtcactgg catctgagcc ctgctgatgg ctggggctct cgggcatgct tgggagtgca     2280

gggggctcgg gctgcctggc ctggctgcac agaaggcaag tgctggggct catggtgctc     2340

tgagctggcc tggaccctgt caggatgggc cccacctcag aaccaaactc actgtcccca     2400

ctgtggcatg agggcagtgg agcaccatgt ttgagggcga agggcagagc gtttgtgtgt     2460

tctggggagg gaaggaaaag gtgttggagg ccttaattat ggactgttgg gaaaagggtt     2520

ttgtccagaa ggacaagccg gacaaatgag cgacttctgt gcttccagag gaagacgagg     2580

gagcaggagc ttggctgact gctcagagtc tgttctgacg ccctgggggt tcctgtccaa     2640

ccccagcagg ggcgcagcgg gaccagcccc acattccact tgtgtcactg cttggaacct     2700

atttattttg tatttatttg aacagagtta tgtcctaact atttttatag atttgtttaa     2760

ttaatagctt gtcattttca agttcatttt ttattcatat ttatgttcat ggttgattgt     2820

accttcccaa gcccgcccag tgggatggga ggaggaggag aaggggggcc ttgggccgct     2880

gcagtcacat ctgtccagag aaattccttt tgggactgga ggcagaaaag cggccagaag     2940

gcagcagccc tggctccttt cctttggcag gttggggaag ggcttgcccc cagccttagg     3000

atttcagggt ttgactgggg gcgtggagag agagggagga acctcaataa ccttgaaggt     3060

ggaatccagt tatttcctgc gctgcgaggg tttctttatt tcactctttt ctgaatgtca     3120

aggcagtgag gtgcctctca ctgtgaattt gtggtgggcg ggggctggag gagagggtgg     3180

gggactggct ccgtccctcc cagccttctg ctgcccttgc ttaacaatgc cggccaactg     3240

gcgacctcac ggttgcactt ccattccacc agaatgacct gatgaggaaa tcttcaatag     3300

gatgcaaaga tcaatgcaaa aattgttata tatgaacata taactggagt cgtcaaaaag     3360

caaattaaga aagaattgga cgttagaagt tgtcatttaa agcagccttc taataaagtt     3420

gtttcaaagc tga                                                        3433


<210>  403
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Val Ser Ser Val Leu Cys Arg Cys Val Ala Ser Pro Pro Pro Asp 
1               5                   10                  15      


Ala Ala Ala Thr Ala Ala Ser Ser Ser Ala Ser Ser Pro Ala Ser Val 
            20                  25                  30          


Gly Asp Pro Cys Gly Gly Ala Ile Cys Gly Gly Pro Asp His Arg Leu 
        35                  40                  45              


Arg Leu Trp Arg Leu Phe Gln Thr Leu Asp Val Asn Arg Asp Gly Gly 
    50                  55                  60                  


Leu Cys Val Asn Asp Leu Ala Val Gly Leu Arg Arg Leu Gly Leu His 
65                  70                  75                  80  


Arg Thr Glu Gly Glu Leu Gln Lys Ile Val Gln Ala Gly Asp Lys Asp 
                85                  90                  95      


Leu Asp Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu Gln Asp 
            100                 105                 110         


His Glu Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys Lys Asn 
        115                 120                 125             


Asp Gly Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg Asp Leu 
    130                 135                 140                 


Gly Val Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys Ser Met 
145                 150                 155                 160 


Asp Lys Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg Asp Tyr 
                165                 170                 175     


His Leu Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu Tyr Trp 
            180                 185                 190         


Lys His Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val Pro Asp 
        195                 200                 205             


Glu Phe Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg His Leu 
    210                 215                 220                 


Val Ala Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr Ala Pro 
225                 230                 235                 240 


Leu Asp Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg Ser Asn 
                245                 250                 255     


Asn Met Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu Gly Gly 
            260                 265                 270         


Ala Arg Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala 
        275                 280                 285             


Pro Glu Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Leu 
    290                 295                 300                 


Val Gly Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu Val Ala 
305                 310                 315                 320 


Gly Ser Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro Met Glu 
                325                 330                 335     


Val Leu Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr Ser Gly 
            340                 345                 350         


Met Leu Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val Ala Ala 
        355                 360                 365             


Phe Tyr Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro Tyr Ala 
    370                 375                 380                 


Gly Ile Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gln 
385                 390                 395                 400 


His Tyr Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu Leu Ala 
                405                 410                 415     


Cys Gly Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu 
            420                 425                 430         


Ala Leu Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Ala 
        435                 440                 445             


Pro Glu Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg Thr Glu 
    450                 455                 460                 


Gly Ala Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met Lys Val 
465                 470                 475                 480 


Ile Pro Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu Lys Ile 
                485                 490                 495     


Thr Leu Gly Val Gln Ser Arg 
            500             


<210>  404
<211>  3293
<212>  DNA
<213>  Homo sapiens

<400>  404
gaggcgtttg gaggagaccg tgatgttgca gatgctgtgg catttcctag ctagcttttt       60

ccccagggct gggtgccacg gctccagaga gggggacgat cgtgaagtca gaggcacccc      120

agcccctgcc tggagagacc agatggcaag ctttttgggg aaacaggacg gaagggctga      180

ggccacggaa aaaagaccca ccattttgct ggtggttgga cctgcagagc agtttcctaa      240

gaaaattgta caagctggag ataaggacct tgatgggcag ctagactttg aagaatttgt      300

ccattatctc caagatcatg agaagaagct gaggctggtg tttaagagtt tggacaaaaa      360

gaatgatgga cgcattgacg cgcaggagat catgcagtcc ctgcgggact tgggagtcaa      420

gatatctgaa cagcaggcag aaaaaattct caagagcatg gataaaaacg gcacgatgac      480

catcgactgg aacgagtgga gagactacca cctcctccac cccgtggaaa acatccccga      540

gatcatcctc tactggaagc attccacgat ctttgatgtg ggtgagaatc taacggtccc      600

ggatgagttc acagtggagg agaggcagac ggggatgtgg tggagacacc tggtggcagg      660

aggtggggca ggggccgtat ccagaacctg cacggccccc ctggacaggc tcaaggtgct      720

catgcaggtc catgcctccc gcagcaacaa catgggcatc gttggtggct tcactcagat      780

gattcgagaa ggaggggcca ggtcactctg gcggggcaat ggcatcaacg tcctcaaaat      840

tgcccccgaa tcagccatca aattcatggc ctatgagcag atcaagcgcc ttgttggtag      900

tgaccaggag actctgagga ttcacgagag gcttgtggca gggtccttgg caggggccat      960

cgcccagagc agcatctacc caatggaggt cctgaagacc cggatggcgc tgcggaagac     1020

aggccagtac tcaggaatgc tggactgcgc caggaggatc ctggccagag agggggtggc     1080

cgccttctac aaaggctatg tccccaacat gctgggcatc atcccctatg ccggcatcga     1140

ccttgcagtc tacgagacgc tcaagaatgc ctggctgcag cactatgcag tgaacagcgc     1200

ggaccccggc gtgtttgtgc tcctggcctg tggcaccatg tccagtacct gtggccagct     1260

ggccagctac cccctggccc tagtcaggac ccggatgcag gcgcaagcct ctattgaggg     1320

cgctccggag gtgaccatga gcagcctctt caaacatatc ctgcggaccg agggggcctt     1380

cgggctgtac agggggctgg cccccaactt catgaaggtc atcccagctg tgagcatcag     1440

ctacgtggtc tacgagaacc tgaagatcac cctgggcgtg cagtcgcggt gacgggggga     1500

gggccgcccg gcagtggact cgctgatcct gggccgcagc ctggggtgtg cagccatctc     1560

attctgtgaa tgtgccaaca ctaagctgtc tcgagccaag ctgtgaaaac cctagacgca     1620

cccgcaggga gggtggggag agctggcagg cccagggctt gtcctgctga ccccagcaga     1680

ccctcctgtt ggttccagcg aagaccacag gcattcctta gggtccaggg tcagcaggct     1740

ccgggctcac atgtgtaagg acaggacatt ttctgcagtg cctgccaata gcgagcttgg     1800

agcctggagg ccggcttagt tcttccattt cacccttgca gccagctgtt ggccacggcc     1860

cctgccctct ggtctgccgt gcatctccct gtgccctctt gctgcctgcc tgtctgctga     1920

ggtaaggtgg gaggagggct acagcccaca tcccaccccc tcgtccaatc ccataatcca     1980

tgatgaaagg tgaggtcacg tggcctccca ggcctgactt cccaacctac agcattgacg     2040

ccaacttggc tgtgaaggaa gaggaaagga tctggccttg tggtcactgg catctgagcc     2100

ctgctgatgg ctggggctct cgggcatgct tgggagtgca gggggctcgg gctgcctggc     2160

ctggctgcac agaaggcaag tgctggggct catggtgctc tgagctggcc tggaccctgt     2220

caggatgggc cccacctcag aaccaaactc actgtcccca ctgtggcatg agggcagtgg     2280

agcaccatgt ttgagggcga agggcagagc gtttgtgtgt tctggggagg gaaggaaaag     2340

gtgttggagg ccttaattat ggactgttgg gaaaagggtt ttgtccagaa ggacaagccg     2400

gacaaatgag cgacttctgt gcttccagag gaagacgagg gagcaggagc ttggctgact     2460

gctcagagtc tgttctgacg ccctgggggt tcctgtccaa ccccagcagg ggcgcagcgg     2520

gaccagcccc acattccact tgtgtcactg cttggaacct atttattttg tatttatttg     2580

aacagagtta tgtcctaact atttttatag atttgtttaa ttaatagctt gtcattttca     2640

agttcatttt ttattcatat ttatgttcat ggttgattgt accttcccaa gcccgcccag     2700

tgggatggga ggaggaggag aaggggggcc ttgggccgct gcagtcacat ctgtccagag     2760

aaattccttt tgggactgga ggcagaaaag cggccagaag gcagcagccc tggctccttt     2820

cctttggcag gttggggaag ggcttgcccc cagccttagg atttcagggt ttgactgggg     2880

gcgtggagag agagggagga acctcaataa ccttgaaggt ggaatccagt tatttcctgc     2940

gctgcgaggg tttctttatt tcactctttt ctgaatgtca aggcagtgag gtgcctctca     3000

ctgtgaattt gtggtgggcg ggggctggag gagagggtgg gggactggct ccgtccctcc     3060

cagccttctg ctgcccttgc ttaacaatgc cggccaactg gcgacctcac ggttgcactt     3120

ccattccacc agaatgacct gatgaggaaa tcttcaatag gatgcaaaga tcaatgcaaa     3180

aattgttata tatgaacata taactggagt cgtcaaaaag caaattaaga aagaattgga     3240

cgttagaagt tgtcatttaa agcagccttc taataaagtt gtttcaaagc tga            3293


<210>  405
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Leu Gln Met Leu Trp His Phe Leu Ala Ser Phe Phe Pro Arg Ala 
1               5                   10                  15      


Gly Cys His Gly Ser Arg Glu Gly Asp Asp Arg Glu Val Arg Gly Thr 
            20                  25                  30          


Pro Ala Pro Ala Trp Arg Asp Gln Met Ala Ser Phe Leu Gly Lys Gln 
        35                  40                  45              


Asp Gly Arg Ala Glu Ala Thr Glu Lys Arg Pro Thr Ile Leu Leu Val 
    50                  55                  60                  


Val Gly Pro Ala Glu Gln Phe Pro Lys Lys Ile Val Gln Ala Gly Asp 
65                  70                  75                  80  


Lys Asp Leu Asp Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu 
                85                  90                  95      


Gln Asp His Glu Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys 
            100                 105                 110         


Lys Asn Asp Gly Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg 
        115                 120                 125             


Asp Leu Gly Val Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys 
    130                 135                 140                 


Ser Met Asp Lys Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg 
145                 150                 155                 160 


Asp Tyr His Leu Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu 
                165                 170                 175     


Tyr Trp Lys His Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val 
            180                 185                 190         


Pro Asp Glu Phe Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg 
        195                 200                 205             


His Leu Val Ala Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr 
    210                 215                 220                 


Ala Pro Leu Asp Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg 
225                 230                 235                 240 


Ser Asn Asn Met Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu 
                245                 250                 255     


Gly Gly Ala Arg Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys 
            260                 265                 270         


Ile Ala Pro Glu Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys 
        275                 280                 285             


Arg Leu Val Gly Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu 
    290                 295                 300                 


Val Ala Gly Ser Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro 
305                 310                 315                 320 


Met Glu Val Leu Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr 
                325                 330                 335     


Ser Gly Met Leu Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val 
            340                 345                 350         


Ala Ala Phe Tyr Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro 
        355                 360                 365             


Tyr Ala Gly Ile Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp 
    370                 375                 380                 


Leu Gln His Tyr Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu 
385                 390                 395                 400 


Leu Ala Cys Gly Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr 
                405                 410                 415     


Pro Leu Ala Leu Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu 
            420                 425                 430         


Gly Ala Pro Glu Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg 
        435                 440                 445             


Thr Glu Gly Ala Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met 
    450                 455                 460                 


Lys Val Ile Pro Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu 
465                 470                 475                 480 


Lys Ile Thr Leu Gly Val Gln Ser Arg 
                485                 


<210>  406
<211>  3264
<212>  DNA
<213>  Homo sapiens

<400>  406
ggccgccaac atgctctgtc tgtgcctgta cgtgccggtc atcggggaag cccagaccga       60

gttccagtac tttgagtcga aggggctccc tgccgagctg aagtccattt tcaagctcag      120

tgtcttcatc ccctcccagg aattctccac ctaccgccag tggaagcagg tctgtggggt      180

gaccgcgcgg aagggagagg cgcgttcaac cgaaaattgt acaagctgga gataaggacc      240

ttgatgggca gctagacttt gaagaatttg tccattatct ccaagatcat gagaagaagc      300

tgaggctggt gtttaagagt ttggacaaaa agaatgatgg acgcattgac gcgcaggaga      360

tcatgcagtc cctgcgggac ttgggagtca agatatctga acagcaggca gaaaaaattc      420

tcaagagcat ggataaaaac ggcacgatga ccatcgactg gaacgagtgg agagactacc      480

acctcctcca ccccgtggaa aacatccccg agatcatcct ctactggaag cattccacga      540

tctttgatgt gggtgagaat ctaacggtcc cggatgagtt cacagtggag gagaggcaga      600

cggggatgtg gtggagacac ctggtggcag gaggtggggc aggggccgta tccagaacct      660

gcacggcccc cctggacagg ctcaaggtgc tcatgcaggt ccatgcctcc cgcagcaaca      720

acatgggcat cgttggtggc ttcactcaga tgattcgaga aggaggggcc aggtcactct      780

ggcggggcaa tggcatcaac gtcctcaaaa ttgcccccga atcagccatc aaattcatgg      840

cctatgagca gatcaagcgc cttgttggta gtgaccagga gactctgagg attcacgaga      900

ggcttgtggc agggtccttg gcaggggcca tcgcccagag cagcatctac ccaatggagg      960

tcctgaagac ccggatggcg ctgcggaaga caggccagta ctcaggaatg ctggactgcg     1020

ccaggaggat cctggccaga gagggggtgg ccgccttcta caaaggctat gtccccaaca     1080

tgctgggcat catcccctat gccggcatcg accttgcagt ctacgagacg ctcaagaatg     1140

cctggctgca gcactatgca gtgaacagcg cggaccccgg cgtgtttgtg ctcctggcct     1200

gtggcaccat gtccagtacc tgtggccagc tggccagcta ccccctggcc ctagtcagga     1260

cccggatgca ggcgcaagcc tctattgagg gcgctccgga ggtgaccatg agcagcctct     1320

tcaaacatat cctgcggacc gagggggcct tcgggctgta cagggggctg gcccccaact     1380

tcatgaaggt catcccagct gtgagcatca gctacgtggt ctacgagaac ctgaagatca     1440

ccctgggcgt gcagtcgcgg tgacgggggg agggccgccc ggcagtggac tcgctgatcc     1500

tgggccgcag cctggggtgt gcagccatct cattctgtga atgtgccaac actaagctgt     1560

ctcgagccaa gctgtgaaaa ccctagacgc acccgcaggg agggtgggga gagctggcag     1620

gcccagggct tgtcctgctg accccagcag accctcctgt tggttccagc gaagaccaca     1680

ggcattcctt agggtccagg gtcagcaggc tccgggctca catgtgtaag gacaggacat     1740

tttctgcagt gcctgccaat agcgagcttg gagcctggag gccggcttag ttcttccatt     1800

tcacccttgc agccagctgt tggccacggc ccctgccctc tggtctgccg tgcatctccc     1860

tgtgccctct tgctgcctgc ctgtctgctg aggtaaggtg ggaggagggc tacagcccac     1920

atcccacccc ctcgtccaat cccataatcc atgatgaaag gtgaggtcac gtggcctccc     1980

aggcctgact tcccaaccta cagcattgac gccaacttgg ctgtgaagga agaggaaagg     2040

atctggcctt gtggtcactg gcatctgagc cctgctgatg gctggggctc tcgggcatgc     2100

ttgggagtgc agggggctcg ggctgcctgg cctggctgca cagaaggcaa gtgctggggc     2160

tcatggtgct ctgagctggc ctggaccctg tcaggatggg ccccacctca gaaccaaact     2220

cactgtcccc actgtggcat gagggcagtg gagcaccatg tttgagggcg aagggcagag     2280

cgtttgtgtg ttctggggag ggaaggaaaa ggtgttggag gccttaatta tggactgttg     2340

ggaaaagggt tttgtccaga aggacaagcc ggacaaatga gcgacttctg tgcttccaga     2400

ggaagacgag ggagcaggag cttggctgac tgctcagagt ctgttctgac gccctggggg     2460

ttcctgtcca accccagcag gggcgcagcg ggaccagccc cacattccac ttgtgtcact     2520

gcttggaacc tatttatttt gtatttattt gaacagagtt atgtcctaac tatttttata     2580

gatttgttta attaatagct tgtcattttc aagttcattt tttattcata tttatgttca     2640

tggttgattg taccttccca agcccgccca gtgggatggg aggaggagga gaaggggggc     2700

cttgggccgc tgcagtcaca tctgtccaga gaaattcctt ttgggactgg aggcagaaaa     2760

gcggccagaa ggcagcagcc ctggctcctt tcctttggca ggttggggaa gggcttgccc     2820

ccagccttag gatttcaggg tttgactggg ggcgtggaga gagagggagg aacctcaata     2880

accttgaagg tggaatccag ttatttcctg cgctgcgagg gtttctttat ttcactcttt     2940

tctgaatgtc aaggcagtga ggtgcctctc actgtgaatt tgtggtgggc gggggctgga     3000

ggagagggtg ggggactggc tccgtccctc ccagccttct gctgcccttg cttaacaatg     3060

ccggccaact ggcgacctca cggttgcact tccattccac cagaatgacc tgatgaggaa     3120

atcttcaata ggatgcaaag atcaatgcaa aaattgttat atatgaacat ataactggag     3180

tcgtcaaaaa gcaaattaag aaagaattgg acgttagaag ttgtcattta aagcagcctt     3240

ctaataaagt tgtttcaaag ctga                                            3264


<210>  407
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Gln Ser Leu Arg Asp Leu Gly Val Lys Ile Ser Glu Gln Gln Ala 
1               5                   10                  15      


Glu Lys Ile Leu Lys Ser Met Asp Lys Asn Gly Thr Met Thr Ile Asp 
            20                  25                  30          


Trp Asn Glu Trp Arg Asp Tyr His Leu Leu His Pro Val Glu Asn Ile 
        35                  40                  45              


Pro Glu Ile Ile Leu Tyr Trp Lys His Ser Thr Ile Phe Asp Val Gly 
    50                  55                  60                  


Glu Asn Leu Thr Val Pro Asp Glu Phe Thr Val Glu Glu Arg Gln Thr 
65                  70                  75                  80  


Gly Met Trp Trp Arg His Leu Val Ala Gly Gly Gly Ala Gly Ala Val 
                85                  90                  95      


Ser Arg Thr Cys Thr Ala Pro Leu Asp Arg Leu Lys Val Leu Met Gln 
            100                 105                 110         


Val His Ala Ser Arg Ser Asn Asn Met Gly Ile Val Gly Gly Phe Thr 
        115                 120                 125             


Gln Met Ile Arg Glu Gly Gly Ala Arg Ser Leu Trp Arg Gly Asn Gly 
    130                 135                 140                 


Ile Asn Val Leu Lys Ile Ala Pro Glu Ser Ala Ile Lys Phe Met Ala 
145                 150                 155                 160 


Tyr Glu Gln Ile Lys Arg Leu Val Gly Ser Asp Gln Glu Thr Leu Arg 
                165                 170                 175     


Ile His Glu Arg Leu Val Ala Gly Ser Leu Ala Gly Ala Ile Ala Gln 
            180                 185                 190         


Ser Ser Ile Tyr Pro Met Glu Val Leu Lys Thr Arg Met Ala Leu Arg 
        195                 200                 205             


Lys Thr Gly Gln Tyr Ser Gly Met Leu Asp Cys Ala Arg Arg Ile Leu 
    210                 215                 220                 


Ala Arg Glu Gly Val Ala Ala Phe Tyr Lys Gly Tyr Val Pro Asn Met 
225                 230                 235                 240 


Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp Leu Ala Val Tyr Glu Thr 
                245                 250                 255     


Leu Lys Asn Ala Trp Leu Gln His Tyr Ala Val Asn Ser Ala Asp Pro 
            260                 265                 270         


Gly Val Phe Val Leu Leu Ala Cys Gly Thr Met Ser Ser Thr Cys Gly 
        275                 280                 285             


Gln Leu Ala Ser Tyr Pro Leu Ala Leu Val Arg Thr Arg Met Gln Ala 
    290                 295                 300                 


Gln Ala Ser Ile Glu Gly Ala Pro Glu Val Thr Met Ser Ser Leu Phe 
305                 310                 315                 320 


Lys His Ile Leu Arg Thr Glu Gly Ala Phe Gly Leu Tyr Arg Gly Leu 
                325                 330                 335     


Ala Pro Asn Phe Met Lys Val Ile Pro Ala Val Ser Ile Ser Tyr Val 
            340                 345                 350         


Val Tyr Glu Asn Leu Lys Ile Thr Leu Gly Val Gln Ser Arg 
        355                 360                 365     


<210>  408
<211>  3240
<212>  DNA
<213>  Homo sapiens

<400>  408
ggcagtggag cacccagcag gccgccaaca tgctctgtct gtgcctgtac gtgccggtca       60

tcggggaagc ccagaccgag ttccagtact ttgagtcgaa ggggctccct gccgagctga      120

agtccatttt caagctcagt gtcttcatcc cctcccagga attctccacc taccgccagt      180

ggaagcagaa aattgtacaa gctggagata aggaccttga tgggcagcta gactttgaag      240

aatttgtcca ttatctccaa gatcatgaga agaagctgag gctggtgttt aagagtttgg      300

acaaaaagaa tgatggacgc attgacgcgc aggagatcat gcagtccctg cgggacttgg      360

gagtcaagat atctgaacag caggcagaaa aaattctcaa gagcatggat aaaaacggca      420

cgatgaccat cgactggaac gagtggagag actaccacct cctccacccc gtggaaaaca      480

tccccgagat catcctctac tggaagcatt ccacgatctt tgatgtgggt gagaatctaa      540

cggtcccgga tgagttcaca gtggaggaga ggcagacggg gatgtggtgg agacacctgg      600

tggcaggagg tggggcaggg gccgtatcca gaacctgcac ggcccccctg gacaggctca      660

aggtgctcat gcaggtccat gcctcccgca gcaacaacat gggcatcgtt ggtggcttca      720

ctcagatgat tcgagaagga ggggccaggt cactctggcg gggcaatggc atcaacgtcc      780

tcaaaattgc ccccgaatca gccatcaaat tcatggccta tgagcagatc aagcgccttg      840

ttggtagtga ccaggagact ctgaggattc acgagaggct tgtggcaggg tccttggcag      900

gggccatcgc ccagagcagc atctacccaa tggaggtcct gaagacccgg atggcgctgc      960

ggaagacagg ccagtactca ggaatgctgg actgcgccag gaggatcctg gccagagagg     1020

gggtggccgc cttctacaaa ggctatgtcc ccaacatgct gggcatcatc ccctatgccg     1080

gcatcgacct tgcagtctac gagacgctca agaatgcctg gctgcagcac tatgcagtga     1140

acagcgcgga ccccggcgtg tttgtgctcc tggcctgtgg caccatgtcc agtacctgtg     1200

gccagctggc cagctacccc ctggccctag tcaggacccg gatgcaggcg caagcctcta     1260

ttgagggcgc tccggaggtg accatgagca gcctcttcaa acatatcctg cggaccgagg     1320

gggccttcgg gctgtacagg gggctggccc ccaacttcat gaaggtcatc ccagctgtga     1380

gcatcagcta cgtggtctac gagaacctga agatcaccct gggcgtgcag tcgcggtgac     1440

ggggggaggg ccgcccggca gtggactcgc tgatcctggg ccgcagcctg gggtgtgcag     1500

ccatctcatt ctgtgaatgt gccaacacta agctgtctcg agccaagctg tgaaaaccct     1560

agacgcaccc gcagggaggg tggggagagc tggcaggccc agggcttgtc ctgctgaccc     1620

cagcagaccc tcctgttggt tccagcgaag accacaggca ttccttaggg tccagggtca     1680

gcaggctccg ggctcacatg tgtaaggaca ggacattttc tgcagtgcct gccaatagcg     1740

agcttggagc ctggaggccg gcttagttct tccatttcac ccttgcagcc agctgttggc     1800

cacggcccct gccctctggt ctgccgtgca tctccctgtg ccctcttgct gcctgcctgt     1860

ctgctgaggt aaggtgggag gagggctaca gcccacatcc caccccctcg tccaatccca     1920

taatccatga tgaaaggtga ggtcacgtgg cctcccaggc ctgacttccc aacctacagc     1980

attgacgcca acttggctgt gaaggaagag gaaaggatct ggccttgtgg tcactggcat     2040

ctgagccctg ctgatggctg gggctctcgg gcatgcttgg gagtgcaggg ggctcgggct     2100

gcctggcctg gctgcacaga aggcaagtgc tggggctcat ggtgctctga gctggcctgg     2160

accctgtcag gatgggcccc acctcagaac caaactcact gtccccactg tggcatgagg     2220

gcagtggagc accatgtttg agggcgaagg gcagagcgtt tgtgtgttct ggggagggaa     2280

ggaaaaggtg ttggaggcct taattatgga ctgttgggaa aagggttttg tccagaagga     2340

caagccggac aaatgagcga cttctgtgct tccagaggaa gacgagggag caggagcttg     2400

gctgactgct cagagtctgt tctgacgccc tgggggttcc tgtccaaccc cagcaggggc     2460

gcagcgggac cagccccaca ttccacttgt gtcactgctt ggaacctatt tattttgtat     2520

ttatttgaac agagttatgt cctaactatt tttatagatt tgtttaatta atagcttgtc     2580

attttcaagt tcatttttta ttcatattta tgttcatggt tgattgtacc ttcccaagcc     2640

cgcccagtgg gatgggagga ggaggagaag gggggccttg ggccgctgca gtcacatctg     2700

tccagagaaa ttccttttgg gactggaggc agaaaagcgg ccagaaggca gcagccctgg     2760

ctcctttcct ttggcaggtt ggggaagggc ttgcccccag ccttaggatt tcagggtttg     2820

actgggggcg tggagagaga gggaggaacc tcaataacct tgaaggtgga atccagttat     2880

ttcctgcgct gcgagggttt ctttatttca ctcttttctg aatgtcaagg cagtgaggtg     2940

cctctcactg tgaatttgtg gtgggcgggg gctggaggag agggtggggg actggctccg     3000

tccctcccag ccttctgctg cccttgctta acaatgccgg ccaactggcg acctcacggt     3060

tgcacttcca ttccaccaga atgacctgat gaggaaatct tcaataggat gcaaagatca     3120

atgcaaaaat tgttatatat gaacatataa ctggagtcgt caaaaagcaa attaagaaag     3180

aattggacgt tagaagttgt catttaaagc agccttctaa taaagttgtt tcaaagctga     3240


<210>  409
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Leu Cys Leu Cys Leu Tyr Val Pro Val Ile Gly Glu Ala Gln Thr 
1               5                   10                  15      


Glu Phe Gln Tyr Phe Glu Ser Lys Gly Leu Pro Ala Glu Leu Lys Ser 
            20                  25                  30          


Ile Phe Lys Leu Ser Val Phe Ile Pro Ser Gln Glu Phe Ser Thr Tyr 
        35                  40                  45              


Arg Gln Trp Lys Gln Lys Ile Val Gln Ala Gly Asp Lys Asp Leu Asp 
    50                  55                  60                  


Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu Gln Asp His Glu 
65                  70                  75                  80  


Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys Lys Asn Asp Gly 
                85                  90                  95      


Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg Asp Leu Gly Val 
            100                 105                 110         


Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys Ser Met Asp Lys 
        115                 120                 125             


Asn Gly Thr Met Thr Ile Asp Trp Asn Glu Trp Arg Asp Tyr His Leu 
    130                 135                 140                 


Leu His Pro Val Glu Asn Ile Pro Glu Ile Ile Leu Tyr Trp Lys His 
145                 150                 155                 160 


Ser Thr Ile Phe Asp Val Gly Glu Asn Leu Thr Val Pro Asp Glu Phe 
                165                 170                 175     


Thr Val Glu Glu Arg Gln Thr Gly Met Trp Trp Arg His Leu Val Ala 
            180                 185                 190         


Gly Gly Gly Ala Gly Ala Val Ser Arg Thr Cys Thr Ala Pro Leu Asp 
        195                 200                 205             


Arg Leu Lys Val Leu Met Gln Val His Ala Ser Arg Ser Asn Asn Met 
    210                 215                 220                 


Gly Ile Val Gly Gly Phe Thr Gln Met Ile Arg Glu Gly Gly Ala Arg 
225                 230                 235                 240 


Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu 
                245                 250                 255     


Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Leu Val Gly 
            260                 265                 270         


Ser Asp Gln Glu Thr Leu Arg Ile His Glu Arg Leu Val Ala Gly Ser 
        275                 280                 285             


Leu Ala Gly Ala Ile Ala Gln Ser Ser Ile Tyr Pro Met Glu Val Leu 
    290                 295                 300                 


Lys Thr Arg Met Ala Leu Arg Lys Thr Gly Gln Tyr Ser Gly Met Leu 
305                 310                 315                 320 


Asp Cys Ala Arg Arg Ile Leu Ala Arg Glu Gly Val Ala Ala Phe Tyr 
                325                 330                 335     


Lys Gly Tyr Val Pro Asn Met Leu Gly Ile Ile Pro Tyr Ala Gly Ile 
            340                 345                 350         


Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gln His Tyr 
        355                 360                 365             


Ala Val Asn Ser Ala Asp Pro Gly Val Phe Val Leu Leu Ala Cys Gly 
    370                 375                 380                 


Thr Met Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu Ala Leu 
385                 390                 395                 400 


Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Ala Pro Glu 
                405                 410                 415     


Val Thr Met Ser Ser Leu Phe Lys His Ile Leu Arg Thr Glu Gly Ala 
            420                 425                 430         


Phe Gly Leu Tyr Arg Gly Leu Ala Pro Asn Phe Met Lys Val Ile Pro 
        435                 440                 445             


Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Leu Lys Ile Thr Leu 
    450                 455                 460                 


Gly Val Gln Ser Arg 
465                 


<210>  410
<211>  4961
<212>  DNA
<213>  Homo sapiens

<400>  410
acaaagagaa ggcgcccggg cggccgcggt cccgcccact gacgcgtccc cggggtgccg       60

ctataacccg ccgctcgcag ggctgctcca cagccgcgcg acgccgccgc cttagaacgc      120

ctttccagta ctgctagcag cagcccgacc acgcgttacc gcacgctcgc gcctttccct      180

tgacacggcg gacgccggag gattggggcg gcaatttgtc ttttcctttt ttattaaaat      240

tatttttcct gcctgttgtt ggatttgggg aaattttttg tttgtttttt atgatttgta      300

tttgactgag agaaacccac tgaagacgtc tgcgtgagaa tagagaccac cgaggccgac      360

tcgcgggccg ctgcacccac cgccaaggac aaaaggagcc cagcgctact agctgcaccc      420

gattcctccc agtgcttagc atgaagaagg ccgaaatggg acgattcagt atttccccgg      480

atgaagacag cagcagctac agttccaaca gcgacttcaa ctactcctac cccaccaagc      540

aagctgctct gaaaagccat tatgcagatg tagatcctga aaaccagaac tttttacttg      600

aatcgaattt ggggaagaag aagtatgaaa cagaatttca tccaggtact acttcctttg      660

gaatgtcagt atttaatctg agcaatgcga ttgtgggcag tggaatcctt gggctttctt      720

atgccatggc taatactgga attgctcttt ttataattct cttgacattt gtgtcaatat      780

tttccctgta ttctgttcat ctccttttga agactgccaa tgaaggaggg tctttattat      840

atgaacaatt gggatataag gcatttggat tagttggaaa gcttgcagca tctggatcaa      900

ttacaatgca gaacattgga gctatgtcaa gctacctctt catagtgaaa tatgagttgc      960

ctttggtgat ccaggcatta acgaacattg aagataaaac tggattgtgg tatctgaacg     1020

ggaactattt ggttctgttg gtgtcattgg tggtcattct tcctttgtcg ctgtttagaa     1080

atttaggata tttgggatat accagtggcc tttccttgtt gtgtatggtg ttctttctga     1140

ttgtggtcat ttgcaagaaa tttcaggttc cgtgtcctgt ggaagctgct ttgataatta     1200

acgaaacaat aaacaccacc ttaacacagc caacagctct tgtacctgct ttgtcacata     1260

acgtgactga aaatgactct tgcagacctc actattttat tttcaactca cagactgtct     1320

atgctgtgcc aattctgatc ttttcatttg tctgtcatcc tgctgttctt cccatctatg     1380

aagaactgaa agaccgcagc cgtagaagaa tgatgaatgt gtccaagatt tcattttttg     1440

ctatgtttct catgtatctg cttgccgccc tctttggata cctaacattt tacgaacatg     1500

ttgagtcaga attgcttcat acctactctt ctatcttggg aactgatatt cttcttctca     1560

ttgtccgtct ggctgtgtta atggctgtga ccctgacagt accagtagtt attttcccaa     1620

tccggagttc tgtaactcac ttgttgtgtg catcaaaaga tttcagttgg tggcgtcata     1680

gtctcattac agtgtctatc ttggcattta ccaatttact tgtcatcttt gtcccaacta     1740

ttagggatat ctttggtttt attggtgcat ctgcagcttc tatgttgatt tttattcttc     1800

cttctgcctt ctatatcaag ttggtgaaga aagaacctat gaaatctgta caaaagattg     1860

gggctttgtt cttcctgtta agtggtgtac tggtgatgac cggaagcatg gccttgattg     1920

ttttggattg ggtacacaat gcacctggag gtggccatta attggcacca ctcaaactca     1980

aactcagtcc atctgatgcc agtgttgagt aaactcaact actatgaaat ttcacctaat     2040

gttttcagtt tcacttcctt ttgaagtgca gattcctcgc tggttcttct gagtgcagaa     2100

taagtgaact tttttgtttt gttttgtttt tttaagaaac ttatctgtat gttagaaatg     2160

gatatgaaca acaaaaccac gagtctcggg ttaagggaag tgacaatttt attccattcc     2220

agagaatgga caaactctta acttttatca agccacatgc ttggctgtgt cattgtttaa     2280

cttggatatt ttatgatttt acttgaatgt gcctaatgga accatttgat gtgagaaaca     2340

attcttttta atttacagca aaatattgaa taaccattga caaaaacact attatttttt     2400

gtaccaaaaa tacttaaaga cctcagaagc actcttttac ttttaagaaa ttgctttttt     2460

gaactttatt cagaagcagt tatcaataaa ttccataaaa taatgtcatt ggtatttaaa     2520

aatgaatatt aatataatga aatggtttgc ctttttgtag gcataataag ccaaatactt     2580

ttttacccaa aataattttt agagaaaatg atgtaatgaa aaattgtacc atgaattagg     2640

agcatagttt tttccattta aacgtcacca ttacttaaaa gatgattgat tattgctata     2700

ccaaatcaga tgaactctgt tcatcacttt tcttctctgt ccccaaacaa tttggttcat     2760

tcagactgaa atgtttgtgt cttcaactta ttagaatgga agataatgca gatatttctg     2820

tgggaaataa aataactaat tttgaggtac caaatagtgc aattgggtaa aacagggttt     2880

attcagttgc atctgtctcc agtgttgtat tgacagctct gggtcttttt ttgggccagc     2940

ccttttttga cattgcttcc agcagtggaa aatgggcatt tgatggcaat aggccaaaat     3000

tattgtgtcc agagagtaca ctttttcaaa atgctcacct actggaagtg tgaattactt     3060

gacaatgtat ggcttagttg tgttcatgtt ttgtctacag tagaggtcta atccacaggt     3120

tacacctatg tttgatatga tataagttct ctttgcgtag gccactgggt ttctcatgca     3180

gtaagcttta taaaaactca tttgcactgg actgtcatct cattcttgta caacgtagaa     3240

ttacttgttt acatccaaca aatggttagc tagggaaaac agtgcaaact gagtgttagt     3300

agtcattttg gtccaactgc atgtcaaccc ttccatttca atcccagtta gaaatgaaaa     3360

taattacttt gaaacttggc tttaagagca catttatcgt acgtcacagt gtatggtgaa     3420

tatattatta aataatgtgg tacttcgctc atcaggcata atgtctaaaa tctaatatac     3480

ataattccat taagtggttg aaggaagcaa ataatggaat tgtcaattgg tcatctggct     3540

gtaaggtttg cccttgaact aaaaatgttg tttggggcaa gggccagaaa tgtggagaca     3600

tggtttttgt tacgcattct tgtattatat gtgactaaat ttacaaacaa gatacatgtg     3660

taattaaaga cccttatgga actggaagac gtcttgtagt gctacattgg gtgaaaccgt     3720

tggtccattt ttgtctgttt ctatgaagat aaaataattg ggggccatct agaaatagaa     3780

aggcagtggg aagacagatt ctacggcact gctttcattt aattgggctt taggcactcc     3840

attcgaatgc agaacctcac ctctagttga gaccaagaat tggcaaattt gcatgagctc     3900

ctggaaagag ttgctgactt tgtatctaag acctgccagg gaataccaag agttgtttct     3960

acagactttt tttttttttt ttgtatggga gaagatactg tggcaaccag gaaggaatgg     4020

aaaaaaaatt cttttctcta cagcaaatta atgtgaggaa gctcctccaa tcctctggct     4080

atttaaggtt caaaatcaag tgcctaggga aaattccaat ggatgatttt ctgggagcta     4140

tcttgtctac cttgaggttc ctgaacaatg aattcccatt aatgagcagt cttcagtatt     4200

aaaaccactg tcttgtcacc tcattttgca ttactgtctt ccgtggatgt ttcagttaca     4260

actgtaatgt tatttataga acaacattaa tccattaaag ctaacctatt tttcaatatt     4320

tatgataatc tatgtacata tattgtctgt ccatatgtat ttgtaaatag gttgtatata     4380

atgtcaggtt tgggtcttgg gttcaagtgt atatattcct gtaagtttct taactgcatt     4440

ttgatgaatt cacattatgt aactataaga attgtcccaa aagtacctgt acagaaaatt     4500

gaatattgaa aaattgacaa attgtgtaca aacactaaaa aaaacttgtt taaattgtat     4560

ttgcaataaa caacatcaaa ttttttcatg aaatcttggt acaaattcag atctcttatt     4620

taaaatttaa ataaggaata cattttcaaa atgcagtaat caaaatgtga tctagtgtaa     4680

tgaaataaaa tgtgatctag tgtaatggaa gacctttgag aacctgggtg tattaacttt     4740

gtgtatatag tgtaaatatc cccactgtac tgttagaggc caacaattct agtatggctt     4800

gttggcaaag agtgctacac cgtttcaatg aaacaatgta tgtttgtttt aactgaacta     4860

aaataaatac atgcttaatc ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         4961


<210>  411
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Lys Lys Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp 
1               5                   10                  15      


Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr 
            20                  25                  30          


Lys Gln Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn 
        35                  40                  45              


Gln Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr 
    50                  55                  60                  


Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met 
                85                  90                  95      


Ala Asn Thr Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu 
        115                 120                 125             


Gly Gly Ser Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu 
    130                 135                 140                 


Val Gly Lys Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly 
145                 150                 155                 160 


Ala Met Ser Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val 
                165                 170                 175     


Ile Gln Ala Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu 
            180                 185                 190         


Asn Gly Asn Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro 
        195                 200                 205             


Leu Ser Leu Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu 
    210                 215                 220                 


Ser Leu Leu Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys 
225                 230                 235                 240 


Phe Gln Val Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr 
                245                 250                 255     


Ile Asn Thr Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser 
            260                 265                 270         


His Asn Val Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe 
        275                 280                 285             


Asn Ser Gln Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val 
    290                 295                 300                 


Cys His Pro Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser 
305                 310                 315                 320 


Arg Arg Arg Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe 
                325                 330                 335     


Leu Met Tyr Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu 
            340                 345                 350         


His Val Glu Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr 
        355                 360                 365             


Asp Ile Leu Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr 
    370                 375                 380                 


Leu Thr Val Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His 
385                 390                 395                 400 


Leu Leu Cys Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile 
                405                 410                 415     


Thr Val Ser Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro 
            420                 425                 430         


Thr Ile Arg Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met 
        435                 440                 445             


Leu Ile Phe Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys 
    450                 455                 460                 


Glu Pro Met Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu 
465                 470                 475                 480 


Ser Gly Val Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp 
                485                 490                 495     


Trp Val His Asn Ala Pro Gly Gly Gly His 
            500                 505     


<210>  412
<211>  4699
<212>  DNA
<213>  Homo sapiens

<400>  412
atatagccgg gcatgcgcgc ggtgccgggg cccggacgca gtgagggggg tcggcgcgcg       60

tgtctacgcg gacgcaccgg ctaagctgct tctgccgccg ccggccgcct gggaccttgc      120

ggtgaggctg cgcggggccg aggccgcctc cgagcgccag gtttattcag tcaccatgaa      180

gctgctgctg ctgcacccgg ccttccagag ctgcctcctg ctgaccctgc ttggcttatg      240

gagaaccacc cctgaggctc acgcttcatc cctgggtgca ccagctatca gcgctgcctc      300

cttcctgcag gatctaatac atcggtatgg cgagggtgac agcctcactc tgcagcagct      360

gaaggcccta ctcaaccacc tggatgtggg agtgggccgg ggtaatgtca cccagcacgt      420

gcaaggacac aggaacctct ccacgtgctt tagttctgga gacctcttca ctgcccacaa      480

tttcagcgag cagtcgcgga ttgggagcag cgagctccag gagttctgcc ccaccatcct      540

ccagcagctg gattcccggg cctgcacctc ggagaaccag gaaaacgagg agaatgagca      600

gacggaggag gggcggccaa gcgctgttga agtgtgggga tacggtctcc tctgtgtgac      660

cgtcatctcc ctctgctccc tcctgggggc cagcgtggtg cccttcatga agaagacctt      720

ttacaagagg ctgctgctct acttcatagc tctggcgatt ggaaccctct actccaacgc      780

cctcttccag ctcatcccgg aggcatttgg tttcaaccct ctggaagatt attatgtctc      840

caagtctgca gtggtgtttg ggggctttta tcttttcttt ttcacagaga agatcttgaa      900

gattcttctt aagcagaaaa atgagcatca tcatggacac agccattatg cctctgagtc      960

gcttccctcc aagaaggacc aggaggaggg ggtgatggag aagctgcaga acggggacct     1020

ggaccacatg attcctcagc actgcagcag tgagctggac ggcaaggcgc ccatggtgga     1080

cgagaaggtc attgtgggct cgctctctgt gcaggacctg caggcttccc agagtgcttg     1140

ctactggctg aaaggtgtcc gctactctga tatcggcact ctggcctgga tgatcactct     1200

gagcgacggc ctccataatt tcatcgatgg cctggccatc ggtgcttcct tcactgtgtc     1260

agttttccaa ggcatcagca cctcggtggc catcctctgt gaggagttcc cacatgagct     1320

aggagacttt gtcatcctgc tcaacgctgg gatgagcatc caacaagctc tcttcttcaa     1380

cttcctttct gcctgctgct gctacctggg tctggccttt ggcatcctgg ccggcagcca     1440

cttctctgcc aactggattt ttgcgctagc tggaggaatg ttcttgtata tttctctggc     1500

tgatatgttc cctgagatga atgaggtctg tcaagaggat gaaaggaagg gcagcatctt     1560

gattccattt atcatccaga acctgggcct cctgactgga ttcaccatca tggtggtcct     1620

caccatgtat tcaggacaga tccagattgg gtagggctct gccaagagcc tgtgggactg     1680

gaagtcgggc cctgggctgc ccgatcgcca gcccgaggac ttaccatcca caatgcacca     1740

cggaagaggc cgttctatga aaaactgaca cagactgtat tcctgcattc aaatgtcagc     1800

cgtttgtaaa atgctgtatc ctaggaataa gctgccctgg taaccagtct ctagctagtg     1860

cctcttgccc tctcctcacc tccttttctc tcagtgactc tggaacctga atgcagctta     1920

caagacaagc ctgacttttt tctctgatta ccttggcctc ctcttggaac cagtgctgaa     1980

aggttttgaa tcctttaccc aacaatgcaa aaatagagcc aatggttata acttggctag     2040

aaatatcaag agttgaatcc atagtgtggg gcccatgact ctagctgggc accttggacc     2100

tccagctggc caatagaaga gacaggagac aggaagcctt cccatttttt caaagtctgt     2160

ttaattgcct attacttctc tcaaagagaa cctgaagtca gaacacatga gcagggtgag     2220

aggtgaggca aggttcatcc tgaatgggag aggaagtcga accactgctg tgtgtcttgt     2280

caggatgctc acttgttcct actgagatgc tggatattga ttttgtaaca gcacctggtg     2340

tttcacggct gtccgagtga gctaacgtgg cggtgtggct gcctggacct cctctttcag     2400

gttaacgctg acagaatgga ggctcaggct gtctgcaaga aaacagttgg tttggctgtg     2460

attttgacct cctcttcccc actgccatct tctaagagac tttgtagctg cctcctagaa     2520

gcacattctg agcacatttg agacctctgt gttagagggg agactgcaca aactatcctc     2580

ccccaggttg agacgtctgc agagtggcaa gctgacttgt agaaatgggg tgccatttat     2640

gctctactta gacaagggta atcagaaatg gaatcagtgc aggcaaaatt taggatttgc     2700

cgcttccata aatcaaagca tgactaatag ggggtctctg aaatgtaagg gcacaaactt     2760

cacttagggc atcgcagatg tttgcagaat ggttggccta atgattatgc tacagatggg     2820

ttttaaatga cccgtctagg ttactgcttc cttgcaaaaa aagtcgaatc ctgcattgaa     2880

ttgaatatga atttctctaa ctctctccag aaaatggatg gagataactt gtctttaaaa     2940

ctgtaggcca gccttagcca ctgtggagcc cttgcctccg agctctggct tcaaggggag     3000

ctcttctcca ggttcactag gtgaattgat ttattattat catattgata atgtgagatt     3060

ctttagccac tttggggagc ctgtctctcc agaagccttt cttagtggtg cccacagttg     3120

gagcccaggg gccatgtttg caaactgatt catgtgcatg gctgacagga gtactggttc     3180

actaccaatg cctgagcttt tctcttacat agaaaaactg tccgctctca gtaatcacaa     3240

gcagcatccg ttttgttttc tcttcttggg agacatctgt caaaccagga atattcttga     3300

aaagaacgtg agcaggaaaa actgctggtg atactttttt taagttttgt ttttatcttg     3360

cctgttggct tcaatacatt tgagaatacg ctgaagaggg aaaatttcag tgatggagat     3420

tctagattaa atatcaggac tgatttcctg gtgggattat ggtccagttt taccaaagaa     3480

ccaattcctt gaatgttgga atctaacttt ttatattgtc attattattg ttgtttttaa     3540

acggttcttt gtcttttctg ttttattttt ctcaagctgc tttcaggagc tagcagaaaa     3600

taactcaaag ttgaagactc tggaagattt tgctttaacc taactcgcat tgatgtatta     3660

aatttataat tttagcattc ccaatagatc ctatcattcc ttaaacataa taccctttgt     3720

cttggagtag aatactaagt tagagttagt ggatttctag tttaggagag gagctcaaaa     3780

ctataatctt taacaaattg aaaaatgaaa tagggtgttt tccctttttg tgcacaccta     3840

tattacctta agaaatttcc ttccatagac agctgcctca aagggaaatc ctctttaaac     3900

cgtagttggc gcagaggtca gtcctagtcg gagcttagga ggggcggaga cgctcacatc     3960

gtctgacttg agtcgccact gattgtggca acagctttgc ctcatgagtc aaaaattggc     4020

aatttctttt gatttttagt tgttgaattt gctgtttcaa gcatttgtac atattagaag     4080

tctaaggagt agcaagtcag tgggaggact ttttcacccc tggcattagc agcttcgacc     4140

tcattttcca gatgcaccag ctcctattaa taagttagca aggaaagtgt atgtcacgtg     4200

caggaacagt gaggcaggga caggggttct gctccttctc acttcaccac cggcacacag     4260

cttgcccctg tctttgcccc caaaggtatt ttgtgtctag tgtcaaattg gagctattct     4320

tcactggtcc ttaaccttgg gttttaaaaa gaaggcttct ctgtttgggt agcgtaagag     4380

ctgagtatag taagtcctct tccaaagaga tggcaatatg ctgggcatct actttaaaac     4440

aaagttgtct gatttttgca agagaggtta ggattttatt gttcttattt ccctttacag     4500

ttctgcagtt ccatcacagt atttttttaa ataactcagg tgtatgagaa gaaattagaa     4560

aagaaaatta acttatgtgg actgtaaatg ttttatttgt aagattctat aaataaagct     4620

atattctgta attgttgaga atcccacggg tgatcatttg caataaatgt ggatgtaatg     4680

aaggctgttg aaaaaaaaa                                                  4699


<210>  413
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  414
<211>  4740
<212>  DNA
<213>  Homo sapiens

<400>  414
cacacgcccg gacggctggg tggaggctgc acctggccgt ggtgccgcgc tggcgagggg       60

agaggtcaag gcgcggcctg tccgcctgga gggtgcggga tgctagagcc gcagaagggt      120

gcccagagcg tgggtcgccg cgccgaaggc tgagccaggc tcccggattc cccgcgcgga      180

cacggacgca gaacgcagac agtttattca gtcaccatga agctgctgct gctgcacccg      240

gccttccaga gctgcctcct gctgaccctg cttggcttat ggagaaccac ccctgaggct      300

cacgcttcat ccctgggtgc accagctatc agcgctgcct ccttcctgca ggatctaata      360

catcggtatg gcgagggtga cagcctcact ctgcagcagc tgaaggccct actcaaccac      420

ctggatgtgg gagtgggccg gggtaatgtc acccagcacg tgcaaggaca caggaacctc      480

tccacgtgct ttagttctgg agacctcttc actgcccaca atttcagcga gcagtcgcgg      540

attgggagca gcgagctcca ggagttctgc cccaccatcc tccagcagct ggattcccgg      600

gcctgcacct cggagaacca ggaaaacgag gagaatgagc agacggagga ggggcggcca      660

agcgctgttg aagtgtgggg atacggtctc ctctgtgtga ccgtcatctc cctctgctcc      720

ctcctggggg ccagcgtggt gcccttcatg aagaagacct tttacaagag gctgctgctc      780

tacttcatag ctctggcgat tggaaccctc tactccaacg ccctcttcca gctcatcccg      840

gaggcatttg gtttcaaccc tctggaagat tattatgtct ccaagtctgc agtggtgttt      900

gggggctttt atcttttctt tttcacagag aagatcttga agattcttct taagcagaaa      960

aatgagcatc atcatggaca cagccattat gcctctgagt cgcttccctc caagaaggac     1020

caggaggagg gggtgatgga gaagctgcag aacggggacc tggaccacat gattcctcag     1080

cactgcagca gtgagctgga cggcaaggcg cccatggtgg acgagaaggt cattgtgggc     1140

tcgctctctg tgcaggacct gcaggcttcc cagagtgctt gctactggct gaaaggtgtc     1200

cgctactctg atatcggcac tctggcctgg atgatcactc tgagcgacgg cctccataat     1260

ttcatcgatg gcctggccat cggtgcttcc ttcactgtgt cagttttcca aggcatcagc     1320

acctcggtgg ccatcctctg tgaggagttc ccacatgagc taggagactt tgtcatcctg     1380

ctcaacgctg ggatgagcat ccaacaagct ctcttcttca acttcctttc tgcctgctgc     1440

tgctacctgg gtctggcctt tggcatcctg gccggcagcc acttctctgc caactggatt     1500

tttgcgctag ctggaggaat gttcttgtat atttctctgg ctgatatgtt ccctgagatg     1560

aatgaggtct gtcaagagga tgaaaggaag ggcagcatct tgattccatt tatcatccag     1620

aacctgggcc tcctgactgg attcaccatc atggtggtcc tcaccatgta ttcaggacag     1680

atccagattg ggtagggctc tgccaagagc ctgtgggact ggaagtcggg ccctgggctg     1740

cccgatcgcc agcccgagga cttaccatcc acaatgcacc acggaagagg ccgttctatg     1800

aaaaactgac acagactgta ttcctgcatt caaatgtcag ccgtttgtaa aatgctgtat     1860

cctaggaata agctgccctg gtaaccagtc tctagctagt gcctcttgcc ctctcctcac     1920

ctccttttct ctcagtgact ctggaacctg aatgcagctt acaagacaag cctgactttt     1980

ttctctgatt accttggcct cctcttggaa ccagtgctga aaggttttga atcctttacc     2040

caacaatgca aaaatagagc caatggttat aacttggcta gaaatatcaa gagttgaatc     2100

catagtgtgg ggcccatgac tctagctggg caccttggac ctccagctgg ccaatagaag     2160

agacaggaga caggaagcct tcccattttt tcaaagtctg tttaattgcc tattacttct     2220

ctcaaagaga acctgaagtc agaacacatg agcagggtga gaggtgaggc aaggttcatc     2280

ctgaatggga gaggaagtcg aaccactgct gtgtgtcttg tcaggatgct cacttgttcc     2340

tactgagatg ctggatattg attttgtaac agcacctggt gtttcacggc tgtccgagtg     2400

agctaacgtg gcggtgtggc tgcctggacc tcctctttca ggttaacgct gacagaatgg     2460

aggctcaggc tgtctgcaag aaaacagttg gtttggctgt gattttgacc tcctcttccc     2520

cactgccatc ttctaagaga ctttgtagct gcctcctaga agcacattct gagcacattt     2580

gagacctctg tgttagaggg gagactgcac aaactatcct cccccaggtt gagacgtctg     2640

cagagtggca agctgacttg tagaaatggg gtgccattta tgctctactt agacaagggt     2700

aatcagaaat ggaatcagtg caggcaaaat ttaggatttg ccgcttccat aaatcaaagc     2760

atgactaata gggggtctct gaaatgtaag ggcacaaact tcacttaggg catcgcagat     2820

gtttgcagaa tggttggcct aatgattatg ctacagatgg gttttaaatg acccgtctag     2880

gttactgctt ccttgcaaaa aaagtcgaat cctgcattga attgaatatg aatttctcta     2940

actctctcca gaaaatggat ggagataact tgtctttaaa actgtaggcc agccttagcc     3000

actgtggagc ccttgcctcc gagctctggc ttcaagggga gctcttctcc aggttcacta     3060

ggtgaattga tttattatta tcatattgat aatgtgagat tctttagcca ctttggggag     3120

cctgtctctc cagaagcctt tcttagtggt gcccacagtt ggagcccagg ggccatgttt     3180

gcaaactgat tcatgtgcat ggctgacagg agtactggtt cactaccaat gcctgagctt     3240

ttctcttaca tagaaaaact gtccgctctc agtaatcaca agcagcatcc gttttgtttt     3300

ctcttcttgg gagacatctg tcaaaccagg aatattcttg aaaagaacgt gagcaggaaa     3360

aactgctggt gatacttttt ttaagttttg tttttatctt gcctgttggc ttcaatacat     3420

ttgagaatac gctgaagagg gaaaatttca gtgatggaga ttctagatta aatatcagga     3480

ctgatttcct ggtgggatta tggtccagtt ttaccaaaga accaattcct tgaatgttgg     3540

aatctaactt tttatattgt cattattatt gttgttttta aacggttctt tgtcttttct     3600

gttttatttt tctcaagctg ctttcaggag ctagcagaaa ataactcaaa gttgaagact     3660

ctggaagatt ttgctttaac ctaactcgca ttgatgtatt aaatttataa ttttagcatt     3720

cccaatagat cctatcattc cttaaacata ataccctttg tcttggagta gaatactaag     3780

ttagagttag tggatttcta gtttaggaga ggagctcaaa actataatct ttaacaaatt     3840

gaaaaatgaa atagggtgtt ttcccttttt gtgcacacct atattacctt aagaaatttc     3900

cttccataga cagctgcctc aaagggaaat cctctttaaa ccgtagttgg cgcagaggtc     3960

agtcctagtc ggagcttagg aggggcggag acgctcacat cgtctgactt gagtcgccac     4020

tgattgtggc aacagctttg cctcatgagt caaaaattgg caatttcttt tgatttttag     4080

ttgttgaatt tgctgtttca agcatttgta catattagaa gtctaaggag tagcaagtca     4140

gtgggaggac tttttcaccc ctggcattag cagcttcgac ctcattttcc agatgcacca     4200

gctcctatta ataagttagc aaggaaagtg tatgtcacgt gcaggaacag tgaggcaggg     4260

acaggggttc tgctccttct cacttcacca ccggcacaca gcttgcccct gtctttgccc     4320

ccaaaggtat tttgtgtcta gtgtcaaatt ggagctattc ttcactggtc cttaaccttg     4380

ggttttaaaa agaaggcttc tctgtttggg tagcgtaaga gctgagtata gtaagtcctc     4440

ttccaaagag atggcaatat gctgggcatc tactttaaaa caaagttgtc tgatttttgc     4500

aagagaggtt aggattttat tgttcttatt tccctttaca gttctgcagt tccatcacag     4560

tattttttta aataactcag gtgtatgaga agaaattaga aaagaaaatt aacttatgtg     4620

gactgtaaat gttttatttg taagattcta taaataaagc tatattctgt aattgttgag     4680

aatcccacgg gtgatcattt gcaataaatg tggatgtaat gaaggctgtt gaaaaaaaaa     4740


<210>  415
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  416
<211>  1793
<212>  DNA
<213>  Homo sapiens

<400>  416
atatagccgg gcatgcgcgc ggtgccgggg cccggacgca gtgagggggg tcggcgcgcg       60

tgtctacgcg gacgcaccgg ctaagctgct tctgccgccg ccggccgcct gggaccttgc      120

ggtgaggctg cgcggggccg aggccgcctc cgagcgccag gtttattcag tcaccatgaa      180

gctgctgctg ctgcacccgg ccttccagag ctgcctcctg ctgaccctgc ttggcttatg      240

gagaaccacc cctgaggctc acgcttcatc cctgggtgca ccagctatca gcgctgcctc      300

cttcctgcag gatctaatac atcggtatgg cgagggtgac agcctcactc tgcagcagct      360

gaaggcccta ctcaaccacc tggatgtggg agtgggccgg ggtaatgtca cccagcacgt      420

gcaaggacac aggaacctct ccacgtgctt tagttctgga gacctcttca ctgcccacaa      480

tttcagcgag cagtcgcgga ttgggagcag cgagctccag gagttctgcc ccaccatcct      540

ccagcagctg gattcccggg cctgcacctc ggagaaccag gaaaacgagg agaatgagca      600

gacggaggag gggcggccaa gcgctgttga agtgtgggga tacggtctcc tctgtgtgac      660

cgtcatctcc ctctgctccc tcctgggggc cagcgtggtg cccttcatga agaagacctt      720

ttacaagagg ctgctgctct acttcatagc tctggcgatt ggaaccctct actccaacgc      780

cctcttccag ctcatcccgg aggcatttgg tttcaaccct ctggaagatt attatgtctc      840

caagtctgca gtggtgtttg ggggctttta tcttttcttt ttcacagaga agatcttgaa      900

gattcttctt aagcagaaaa atgagcatca tcatggacac agccattatg cctctgagtc      960

gcttccctcc aagaaggacc aggaggaggg ggtgatggag aagctgcaga acggggacct     1020

ggaccacatg attcctcagc actgcagcag tgagctggac ggcaaggcgc ccatggtgga     1080

cgagaaggtc attgtgggct cgctctctgt gcaggacctg caggcttccc agagtgcttg     1140

ctactggctg aaaggtgtcc gctactctga tatcggcact ctggcctgga tgatcactct     1200

gagcgacggc ctccataatt tcatcgatgg cctggccatc ggtgcttcct tcactgtgtc     1260

agttttccaa ggcatcagca cctcggtggc catcctctgt gaggagttcc cacatgagct     1320

aggagacttt gtcatcctgc tcaacgctgg gatgagcatc caacaagctc tcttcttcaa     1380

cttcctttct gcctgctgct gctacctggg tctggccttt ggcatcctgg ccggcagcca     1440

cttctctgcc aactggattt ttgcgctagc tggaggaatg ttcttgtata tttctctggc     1500

tgatatgatg gagttttgct ctgttgccca ggctggagtg caatggtgcc atctcagctc     1560

actgcaacct ctgccgcttg ggttgaagcg attatcctgt ctaagcctcc cgagtaactg     1620

agccagccat gtttgttaat aaaaatgggg acaatactgt atatatatgg ttatatttta     1680

gctttttcac ttttcagtat ctcctgaggc ttttctcatg tcattaaata tttttctaat     1740

ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1793


<210>  417
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys 
145                 150                 155                 160 


Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro 
                165                 170                 175     


Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Met Glu Phe Cys 
        435                 440                 445             


Ser Val Ala Gln Ala Gly Val Gln Trp Cys His Leu Ser Ser Leu Gln 
    450                 455                 460                 


Pro Leu Pro Leu Gly Leu Lys Arg Leu Ser Cys Leu Ser Leu Pro Ser 
465                 470                 475                 480 


Asn 
    


<210>  418
<211>  4699
<212>  DNA
<213>  Homo sapiens

<400>  418
atatagccgg gcatgcgcgc ggtgccgggg cccggacgca gtgagggggg tcggcgcgcg       60

tgtctacgcg gacgcaccgg ctaagctgct tctgccgccg ccggccgcct gggaccttgc      120

ggtgaggctg cgcggggccg aggccgcctc cgagcgccag gtttattcag tcaccatgaa      180

gctgctgctg ctgcacccgg ccttccagag ctgcctcctg ctgaccctgc ttggcttatg      240

gagaaccacc cctgaggctc acgcttcatc cctgggtgca ccagctatca gcgctgcctc      300

cttcctgcag gatctaatac atcggtatgg cgagggtgac agcctcactc tgcagcagct      360

gaaggcccta ctcaaccacc tggatgtggg agtgggccgg ggtaatgtca cccagcacgt      420

gcaaggacac aggaacctct ccacgtgctt tagttctgga gacctcttca ctgcccacaa      480

tttcagcgag cagtcgcgga ttgggagcag cgagctccag gagttctgcc ccaccatcct      540

ccagcagctg gattcccggg cctgcacctc ggagaaccag gaaaacgagg agaatgagca      600

gacggaggag gggcggccaa gcgctgttga agtgtggggc tttggttttc tcagtgtctc      660

actgattaac ctggcctctc tcctgggagt cctcgtcctg ccctgcacag agaaagcgtt      720

tttcagccgt gtgctcactt acttcatcgc cctgtccatt ggaacgctgc tgtctaacgc      780

gctattccag ctcatcccag aggcatttgg tttcaaccct ctggaagatt attatgtctc      840

caagtctgca gtggtgtttg ggggctttta tcttttcttt ttcacagaga agatcttgaa      900

gattcttctt aagcagaaaa atgagcatca tcatggacac agccattatg cctctgagtc      960

gcttccctcc aagaaggacc aggaggaggg ggtgatggag aagctgcaga acggggacct     1020

ggaccacatg attcctcagc actgcagcag tgagctggac ggcaaggcgc ccatggtgga     1080

cgagaaggtc attgtgggct cgctctctgt gcaggacctg caggcttccc agagtgcttg     1140

ctactggctg aaaggtgtcc gctactctga tatcggcact ctggcctgga tgatcactct     1200

gagcgacggc ctccataatt tcatcgatgg cctggccatc ggtgcttcct tcactgtgtc     1260

agttttccaa ggcatcagca cctcggtggc catcctctgt gaggagttcc cacatgagct     1320

aggagacttt gtcatcctgc tcaacgctgg gatgagcatc caacaagctc tcttcttcaa     1380

cttcctttct gcctgctgct gctacctggg tctggccttt ggcatcctgg ccggcagcca     1440

cttctctgcc aactggattt ttgcgctagc tggaggaatg ttcttgtata tttctctggc     1500

tgatatgttc cctgagatga atgaggtctg tcaagaggat gaaaggaagg gcagcatctt     1560

gattccattt atcatccaga acctgggcct cctgactgga ttcaccatca tggtggtcct     1620

caccatgtat tcaggacaga tccagattgg gtagggctct gccaagagcc tgtgggactg     1680

gaagtcgggc cctgggctgc ccgatcgcca gcccgaggac ttaccatcca caatgcacca     1740

cggaagaggc cgttctatga aaaactgaca cagactgtat tcctgcattc aaatgtcagc     1800

cgtttgtaaa atgctgtatc ctaggaataa gctgccctgg taaccagtct ctagctagtg     1860

cctcttgccc tctcctcacc tccttttctc tcagtgactc tggaacctga atgcagctta     1920

caagacaagc ctgacttttt tctctgatta ccttggcctc ctcttggaac cagtgctgaa     1980

aggttttgaa tcctttaccc aacaatgcaa aaatagagcc aatggttata acttggctag     2040

aaatatcaag agttgaatcc atagtgtggg gcccatgact ctagctgggc accttggacc     2100

tccagctggc caatagaaga gacaggagac aggaagcctt cccatttttt caaagtctgt     2160

ttaattgcct attacttctc tcaaagagaa cctgaagtca gaacacatga gcagggtgag     2220

aggtgaggca aggttcatcc tgaatgggag aggaagtcga accactgctg tgtgtcttgt     2280

caggatgctc acttgttcct actgagatgc tggatattga ttttgtaaca gcacctggtg     2340

tttcacggct gtccgagtga gctaacgtgg cggtgtggct gcctggacct cctctttcag     2400

gttaacgctg acagaatgga ggctcaggct gtctgcaaga aaacagttgg tttggctgtg     2460

attttgacct cctcttcccc actgccatct tctaagagac tttgtagctg cctcctagaa     2520

gcacattctg agcacatttg agacctctgt gttagagggg agactgcaca aactatcctc     2580

ccccaggttg agacgtctgc agagtggcaa gctgacttgt agaaatgggg tgccatttat     2640

gctctactta gacaagggta atcagaaatg gaatcagtgc aggcaaaatt taggatttgc     2700

cgcttccata aatcaaagca tgactaatag ggggtctctg aaatgtaagg gcacaaactt     2760

cacttagggc atcgcagatg tttgcagaat ggttggccta atgattatgc tacagatggg     2820

ttttaaatga cccgtctagg ttactgcttc cttgcaaaaa aagtcgaatc ctgcattgaa     2880

ttgaatatga atttctctaa ctctctccag aaaatggatg gagataactt gtctttaaaa     2940

ctgtaggcca gccttagcca ctgtggagcc cttgcctccg agctctggct tcaaggggag     3000

ctcttctcca ggttcactag gtgaattgat ttattattat catattgata atgtgagatt     3060

ctttagccac tttggggagc ctgtctctcc agaagccttt cttagtggtg cccacagttg     3120

gagcccaggg gccatgtttg caaactgatt catgtgcatg gctgacagga gtactggttc     3180

actaccaatg cctgagcttt tctcttacat agaaaaactg tccgctctca gtaatcacaa     3240

gcagcatccg ttttgttttc tcttcttggg agacatctgt caaaccagga atattcttga     3300

aaagaacgtg agcaggaaaa actgctggtg atactttttt taagttttgt ttttatcttg     3360

cctgttggct tcaatacatt tgagaatacg ctgaagaggg aaaatttcag tgatggagat     3420

tctagattaa atatcaggac tgatttcctg gtgggattat ggtccagttt taccaaagaa     3480

ccaattcctt gaatgttgga atctaacttt ttatattgtc attattattg ttgtttttaa     3540

acggttcttt gtcttttctg ttttattttt ctcaagctgc tttcaggagc tagcagaaaa     3600

taactcaaag ttgaagactc tggaagattt tgctttaacc taactcgcat tgatgtatta     3660

aatttataat tttagcattc ccaatagatc ctatcattcc ttaaacataa taccctttgt     3720

cttggagtag aatactaagt tagagttagt ggatttctag tttaggagag gagctcaaaa     3780

ctataatctt taacaaattg aaaaatgaaa tagggtgttt tccctttttg tgcacaccta     3840

tattacctta agaaatttcc ttccatagac agctgcctca aagggaaatc ctctttaaac     3900

cgtagttggc gcagaggtca gtcctagtcg gagcttagga ggggcggaga cgctcacatc     3960

gtctgacttg agtcgccact gattgtggca acagctttgc ctcatgagtc aaaaattggc     4020

aatttctttt gatttttagt tgttgaattt gctgtttcaa gcatttgtac atattagaag     4080

tctaaggagt agcaagtcag tgggaggact ttttcacccc tggcattagc agcttcgacc     4140

tcattttcca gatgcaccag ctcctattaa taagttagca aggaaagtgt atgtcacgtg     4200

caggaacagt gaggcaggga caggggttct gctccttctc acttcaccac cggcacacag     4260

cttgcccctg tctttgcccc caaaggtatt ttgtgtctag tgtcaaattg gagctattct     4320

tcactggtcc ttaaccttgg gttttaaaaa gaaggcttct ctgtttgggt agcgtaagag     4380

ctgagtatag taagtcctct tccaaagaga tggcaatatg ctgggcatct actttaaaac     4440

aaagttgtct gatttttgca agagaggtta ggattttatt gttcttattt ccctttacag     4500

ttctgcagtt ccatcacagt atttttttaa ataactcagg tgtatgagaa gaaattagaa     4560

aagaaaatta acttatgtgg actgtaaatg ttttatttgt aagattctat aaataaagct     4620

atattctgta attgttgaga atcccacggg tgatcatttg caataaatgt ggatgtaatg     4680

aaggctgttg aaaaaaaaa                                                  4699


<210>  419
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu 
1               5                   10                  15      


Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser 
            20                  25                  30          


Leu Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile 
        35                  40                  45              


His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala 
    50                  55                  60                  


Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln 
65                  70                  75                  80  


His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp 
                85                  90                  95      


Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser 
            100                 105                 110         


Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg 
        115                 120                 125             


Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu 
    130                 135                 140                 


Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Phe Gly Phe Leu Ser 
145                 150                 155                 160 


Val Ser Leu Ile Asn Leu Ala Ser Leu Leu Gly Val Leu Val Leu Pro 
                165                 170                 175     


Cys Thr Glu Lys Ala Phe Phe Ser Arg Val Leu Thr Tyr Phe Ile Ala 
            180                 185                 190         


Leu Ser Ile Gly Thr Leu Leu Ser Asn Ala Leu Phe Gln Leu Ile Pro 
        195                 200                 205             


Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser 
    210                 215                 220                 


Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile 
225                 230                 235                 240 


Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser 
                245                 250                 255     


His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly 
            260                 265                 270         


Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln 
        275                 280                 285             


His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys 
    290                 295                 300                 


Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser 
305                 310                 315                 320 


Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu 
                325                 330                 335     


Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly 
            340                 345                 350         


Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser 
        355                 360                 365             


Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp 
    370                 375                 380                 


Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe 
385                 390                 395                 400 


Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly 
                405                 410                 415     


Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala 
            420                 425                 430         


Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met 
        435                 440                 445             


Asn Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro 
    450                 455                 460                 


Phe Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val 
465                 470                 475                 480 


Val Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly 
                485                 490         


<210>  420
<211>  5275
<212>  DNA
<213>  Homo sapiens

<400>  420
gagggcgggg cgcaggcgcg gttagtaccg cggtgggcgc cggggctccc gggaatctac       60

cttctcctgc ggccggcacg cggttcccag ggggccagcg gcggtcagcc gaggtcgaga      120

cgcccgcagg gtggccttag cggccggtcg taccacggca gccccgccga tcaggttcct      180

ttgggagact tcgacttgtt ggcgaaatga accggagaag aatcccaatt gggaattgcg      240

gaaaacagga ctctagggta gagaaaggtt gtagaaccaa tagggtttga gacctgatgg      300

ccaaaagaaa ggaagaaaat ttttcctctc ctaaaaatgc caaaaggcca agacaagaag      360

aattggagga ttttgataaa gatggtgacg aagacgaatg taaaggtact actttgactg      420

cagcagaagt tggaataatt gagagtattc acctaaaaaa cttcatgtgt cattcaatgc      480

ttggaccttt taagtttggt tctaatgtca actttgttgt tggcaacaat ggaagtggga      540

agagtgcagt actcacagct ctcatagtcg gtcttggtgg aagagcagtt gctactaata      600

gaggatcctc tttaaaaggt tttgtgaaag atggacagaa ctctgcagat atctcaataa      660

cattgaggaa cagaggagat gatgccttta aagccagtgt gtatggtaac tctatactta      720

tacagcaaca catcagcata gatggaagtc gatcttataa acttaaaagt gcaacaggct      780

ccgtggtttc cacgaggaaa gaagagctga ttgcaattct tgatcatttt aacatccagg      840

tggataatcc agtttctgtt ttaacacaag aaatgagcaa gcagttctta cagtctaaaa      900

atgaaggaga caaatacaaa ttcttcatga aagcaacgca acttgaacag atgaaggaag      960

attattcata cattatggaa acgaaagaaa gaacaaagga gcagatacat caaggagaag     1020

agcggcttac tgaactaaag cgccagtgtg tagagaaaga ggaacgtttt caaagtattg     1080

ctggtttaag tacaatgaag actaatttag agtccttgaa acatgaaatg gcttgggcag     1140

tggtcaatga aattgaaaaa caattgaatg ccatcagaga taatatcaaa attggagaag     1200

atcgtgctgc tagacttgac aggaaaatgg aagaacagca ggtcagactt aatgaggcag     1260

aacaaaagta caaggatatt caagacaaac tagaaaagat tagtgaagag acaaatgcac     1320

gagcaccaga atgtatggca ttgaaagcag atgttgttgc taagaaaagg gcctataatg     1380

aagctgaggt tttatataac cgatccttaa acgaatataa agcattaaag aaagatgatg     1440

agcagctttg taaacgaatt gaagagctga aaaaaagtac tgaccaatct ttggaacctg     1500

aacggttgga aagacaaaaa aaaatatctt ggttaaaaga gagagtaaag gcctttcaaa     1560

atcaagaaaa ttcagtcaat caagagatcg aacagtttca gcaagccata gaaaaggaca     1620

aagaagaaca tggcaaaatt aagagagaag aattagatgt gaagcatgca ctgagctaca     1680

atcagaggca actgaaagaa ttgaaagata gtaaaactga tcgactcaaa agatttggcc     1740

ctaatgttcc agctcttctt gaagccatag atgatgctta tagacaagga cattttacct     1800

ataaacctgt aggcccttta ggagcttgca ttcatcttcg ggacccagaa cttgctttgg     1860

ctattgaatc ttgcttaaaa gggcttctgc aggcctattg ttgccataat catgctgatg     1920

aaagggtcct tcaggcactc atgaaaaggt tttatttacc agggacctca cggccaccga     1980

taatagtttc tgagtttcgg aatgagatat atgatgtaag acacagagct gcttatcatc     2040

cagactttcc aacagttctg acagctttag aaatagataa tgcggttgtg gcaaatagcc     2100

taattgacat gagaggcata gagacagtgc tactaatcaa aaataattct gtagctcgtg     2160

cagtaatgca gtcccaaaag ccacccaaaa attgtagaga agcttttact gctgatggtg     2220

atcaagtttt tgcaggacgt tattattcat ctgaaaatac aagacctaag ttcctaagca     2280

gagatgtgga ttctgaaata agtgacttgg agaatgaggt tgaaaataag acggcccaga     2340

tattaaatct tcagcaacat ttatctgccc ttgaaaaaga tattaaacac aatgaggaac     2400

ttcttaaaag gtgccaacta cattataaag aactaaagat gaaaataaga aaaaatattt     2460

ctgaaattcg ggaacttgag aacatagaag aacaccagtc tgtagatatt gcaactttgg     2520

aagatgaagc tcaggaaaat aaaagcaaaa tgaaaatggt tgaggaacat atggagcaac     2580

aaaaagaaaa tatggagcat cttaaaagtc tgaaaataga agcagaaaat aagtatgatg     2640

caattaaatt caaaattaat caactatcgg agctagcaga cccacttaag gatgaattaa     2700

accttgctga ttctgaagtg gataaccaaa aacgagggaa acgacattat gaagaaaaac     2760

aaaaagaaca cttggatacc ttaaataaaa agaaacgaga actggatatg aaagagaaag     2820

aactagagga gaaaatgtca caagcaagac aaatctgccc agagcgtata gaagtagaaa     2880

aatctgcatc aattctggac aaagaaatta atcgattaag gcagaagata caggcagaac     2940

atgctagtca tggagatcga gaggaaataa tgaggcagta ccaagaagca agagagacct     3000

atcttgatct ggatagtaaa gtgaggactt taaaaaagtt tattaaatta ctgggagaaa     3060

tcatggagca cagattcaag acatatcaac aatttagaag gtgtttgact ttacgatgca     3120

aattatactt tgacaactta ctatctcagc gggcctattg tggaaaaatg aattttgacc     3180

acaagaatga aactctaagt atatcagttc agcctggaga aggaaataaa gctgctttca     3240

atgacatgag agccttgtct ggaggtgaac gttctttctc cacagtgtgt tttattcttt     3300

ccctgtggtc catcgcagaa tctcctttca gatgcctgga tgaatttgat gtctacatgg     3360

atatggttaa taggagaatt gccatggact tgatactgaa gatggcagat tcccagcgtt     3420

ttagacagtt tatcttgctc acacctcaaa gcatgagttc acttccatcc agtaaactga     3480

taagaattct ccgaatgtct gatcctgaaa gaggacaaac tacattgcct ttcagacctg     3540

tgactcaaga agaagatgat gaccaaaggt gatttgtaac ttaacatgcc ttgtcctgat     3600

gttgaaggat ttgtgaaggg aaaaaaaatt ctggactctt tgatataata aaatgagact     3660

ggaggcattc tgaaatgaaa gaaactcctt tatatatcca accacaatca aacatataaa     3720

taagcctgga aaaccaacta caacctgcaa tttaagatta ctattacttt aagaaaatca     3780

atttcatagt attggtttta aatcttttta agttttttta atacgatcta tttttatagg     3840

ttctttttca gaagtaaaat tttgtacata tatacatgta catatctgtt tagtttgggt     3900

tcatttctat aacattttgt aagaaaataa aagtttgagc acctgattat atttagtttt     3960

gcttttccag atattacatt ctatagttac caaaaatggt tgaagggagg gatttctcat     4020

tgcagagggt ggggtgcaag ggaataagac acttgtacgg aacactgaag ctttgccaac     4080

ttctacacat gccttttttg cagtccttta actgtccacc ctaccaagag cttataacca     4140

gtatcagaac tggataatga cgcagttttt cactctgacc tccatcatgc ttgcctgatt     4200

taaaagccct cagtttgcag tccagggact gttcaggctt gtcctcagct gagaggacac     4260

aggctagagg gactgtgcag aaccaggctg ggagaagggc tgggaaaact gggagtggag     4320

ggtggatcct catggagcag gagagtagct catggctcca ggagcctgag gccatgcagt     4380

tgatggtgag ctgacatcaa ttctaagact catcctaatt gaggggtgtt aaaaagtgtg     4440

ctgcttagaa tgaccaaata tagttattgt aaaaaatgat atttatgaac tttttatttt     4500

agaaaacatg aattttattg ctccctgtat tatttgtttg atactaggat tcatgctaaa     4560

ctttttaaga atgtattgga tatcaagaag cattccttac attagtagca ataaatatta     4620

gaataaatat gaaattgaac tattttcaga aaaagggcag tatattaaga gcagggactg     4680

ttctctagtt attgaggaaa actggacttt gtttgtgttt ttggtggagg aagaagttta     4740

agatacttta gtcttaaatt gaggtttgcc aaatgagaag ttcaaaaact tgggctttct     4800

aatcagaatt tccaggagga ggaaagtgtg tgctgaatat tttaaacatt tcccactgat     4860

catacaaagt ctgattttta aatttacact tataatgcct ttgtattaaa attattttta     4920

acatgtgctt ttccaaatta aaaatgaagt agagtatacc aaatgcataa actttcatta     4980

gctaaggaac tcatgtctga attttgttgt agttttgaat gttgtgctct ttcatacaga     5040

atgggaaaca taatcctcag gtatcccagc atctcttgtt gaattgaaga ttattcattg     5100

ctttggcctc acaaagtttt gatttcaact atcataagtg aaaatatctt cctttaatgt     5160

tctaagtagt gataatatta ctagaatgaa agaataaaaa gaaattgttc ttttaaaata     5220

tgtgtaactt ctaaaaataa aacttaaaat ttatatgtaa aaaaaaaaaa aaaaa          5275


<210>  421
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys 
1               5                   10                  15      


Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu 
            20                  25                  30          


Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile 
        35                  40                  45              


Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro 
    50                  55                  60                  


Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg 
                85                  90                  95      


Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp 
            100                 105                 110         


Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp 
        115                 120                 125             


Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln 
    130                 135                 140                 


His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr 
145                 150                 155                 160 


Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp 
                165                 170                 175     


His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu 
            180                 185                 190         


Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys 
        195                 200                 205             


Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser 
    210                 215                 220                 


Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly 
225                 230                 235                 240 


Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu 
                245                 250                 255     


Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu 
            260                 265                 270         


Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys 
        275                 280                 285             


Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala 
    290                 295                 300                 


Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu 
305                 310                 315                 320 


Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser 
                325                 330                 335     


Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp 
            340                 345                 350         


Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn 
        355                 360                 365             


Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu 
    370                 375                 380                 


Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu 
385                 390                 395                 400 


Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg 
                405                 410                 415     


Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu 
            420                 425                 430         


Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile 
        435                 440                 445             


Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Arg 
    450                 455                 460                 


Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe 
465                 470                 475                 480 


Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg 
                485                 490                 495     


Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile 
            500                 505                 510         


His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys 
        515                 520                 525             


Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val 
    530                 535                 540                 


Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro 
545                 550                 555                 560 


Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His 
                565                 570                 575     


Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu 
            580                 585                 590         


Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile 
        595                 600                 605             


Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met 
    610                 615                 620                 


Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp 
625                 630                 635                 640 


Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg 
                645                 650                 655     


Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu 
            660                 665                 670         


Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His 
        675                 680                 685             


Leu Ser Ala Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys 
    690                 695                 700                 


Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn 
705                 710                 715                 720 


Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val 
                725                 730                 735     


Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met 
            740                 745                 750         


Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His 
        755                 760                 765             


Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys 
    770                 775                 780                 


Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu 
785                 790                 795                 800 


Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg 
                805                 810                 815     


His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys 
            820                 825                 830         


Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser 
        835                 840                 845             


Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala 
    850                 855                 860                 


Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala 
865                 870                 875                 880 


Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln 
                885                 890                 895     


Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu 
            900                 905                 910         


Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys 
        915                 920                 925             


Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr 
    930                 935                 940                 


Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe 
945                 950                 955                 960 


Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly 
                965                 970                 975     


Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg 
            980                 985                 990         


Ser Phe Ser Thr Val Cys Phe Ile  Leu Ser Leu Trp Ser  Ile Ala Glu 
        995                 1000                 1005             


Ser Pro  Phe Arg Cys Leu Asp  Glu Phe Asp Val Tyr  Met Asp Met 
    1010                 1015                 1020             


Val Asn  Arg Arg Ile Ala Met  Asp Leu Ile Leu Lys  Met Ala Asp 
    1025                 1030                 1035             


Ser Gln  Arg Phe Arg Gln Phe  Ile Leu Leu Thr Pro  Gln Ser Met 
    1040                 1045                 1050             


Ser Ser  Leu Pro Ser Ser Lys  Leu Ile Arg Ile Leu  Arg Met Ser 
    1055                 1060                 1065             


Asp Pro  Glu Arg Gly Gln Thr  Thr Leu Pro Phe Arg  Pro Val Thr 
    1070                 1075                 1080             


Gln Glu  Glu Asp Asp Asp Gln  Arg 
    1085                 1090     


<210>  422
<211>  5188
<212>  DNA
<213>  Homo sapiens

<400>  422
gagggcgggg cgcaggcgcg gttagtaccg cggtgggcgc cggggctccc gggaatctac       60

cttctcctgc ggccggcacg cggttcccag ggggccagcg gcggtcagcc gaggtcgaga      120

cgcccgcagg gtggccttag cggccggtcg taccacggca gccccgccga tcaggttcct      180

ttgggagact tcgacttgtt ggcgacctga tggccaaaag aaaggaagaa aatttttcct      240

ctcctaaaaa tgccaaaagg ccaagacaag aagaattgga ggattttgat aaagatggtg      300

acgaagacga atgtaaaggt actactttga ctgcagcaga agttggaata attgagagta      360

ttcacctaaa aaacttcatg tgtcattcaa tgcttggacc ttttaagttt ggttctaatg      420

tcaactttgt tgttggcaac aatggaagtg ggaagagtgc agtactcaca gctctcatag      480

tcggtcttgg tggaagagca gttgctacta atagaggatc ctctttaaaa ggttttgtga      540

aagatggaca gaactctgca gatatctcaa taacattgag gaacagagga gatgatgcct      600

ttaaagccag tgtgtatggt aactctatac ttatacagca acacatcagc atagatggaa      660

gtcgatctta taaacttaaa agtgcaacag gctccgtggt ttccacgagg aaagaagagc      720

tgattgcaat tcttgatcat tttaacatcc aggtggataa tccagtttct gttttaacac      780

aagaaatgag caagcagttc ttacagtcta aaaatgaagg agacaaatac aaattcttca      840

tgaaagcaac gcaacttgaa cagatgaagg aagattattc atacattatg gaaacgaaag      900

aaagaacaaa ggagcagata catcaaggag aagagcggct tactgaacta aagcgccagt      960

gtgtagagaa agaggaacgt tttcaaagta ttgctggttt aagtacaatg aagactaatt     1020

tagagtcctt gaaacatgaa atggcttggg cagtggtcaa tgaaattgaa aaacaattga     1080

atgccatcag agataatatc aaaattggag aagatcgtgc tgctagactt gacaggaaaa     1140

tggaagaaca gcaggtcaga cttaatgagg cagaacaaaa gtacaaggat attcaagaca     1200

aactagaaaa gattagtgaa gagacaaatg cacgagcacc agaatgtatg gcattgaaag     1260

cagatgttgt tgctaagaaa agggcctata atgaagctga ggttttatat aaccgatcct     1320

taaacgaata taaagcatta aagaaagatg atgagcagct ttgtaaacga attgaagagc     1380

tgaaaaaaag tactgaccaa tctttggaac ctgaacggtt ggaaagacaa aaaaaaatat     1440

cttggttaaa agagagagta aaggcctttc aaaatcaaga aaattcagtc aatcaagaga     1500

tcgaacagtt tcagcaagcc atagaaaagg acaaagaaga acatggcaaa attaagagag     1560

aagaattaga tgtgaagcat gcactgagct acaatcagag gcaactgaaa gaattgaaag     1620

atagtaaaac tgatcgactc aaaagatttg gccctaatgt tccagctctt cttgaagcca     1680

tagatgatgc ttatagacaa ggacatttta cctataaacc tgtaggccct ttaggagctt     1740

gcattcatct tcgggaccca gaacttgctt tggctattga atcttgctta aaagggcttc     1800

tgcaggccta ttgttgccat aatcatgctg atgaaagggt ccttcaggca ctcatgaaaa     1860

ggttttattt accagggacc tcacggccac cgataatagt ttctgagttt cggaatgaga     1920

tatatgatgt aagacacaga gctgcttatc atccagactt tccaacagtt ctgacagctt     1980

tagaaataga taatgcggtt gtggcaaata gcctaattga catgagaggc atagagacag     2040

tgctactaat caaaaataat tctgtagctc gtgcagtaat gcagtcccaa aagccaccca     2100

aaaattgtag agaagctttt actgctgatg gtgatcaagt ttttgcagga cgttattatt     2160

catctgaaaa tacaagacct aagttcctaa gcagagatgt ggattctgaa ataagtgact     2220

tggagaatga ggttgaaaat aagacggccc agatattaaa tcttcagcaa catttatctg     2280

cccttgaaaa agatattaaa cacaatgagg aacttcttaa aaggtgccaa ctacattata     2340

aagaactaaa gatgaaaata agaaaaaata tttctgaaat tcgggaactt gagaacatag     2400

aagaacacca gtctgtagat attgcaactt tggaagatga agctcaggaa aataaaagca     2460

aaatgaaaat ggttgaggaa catatggagc aacaaaaaga aaatatggag catcttaaaa     2520

gtctgaaaat agaagcagaa aataagtatg atgcaattaa attcaaaatt aatcaactat     2580

cggagctagc agacccactt aaggatgaat taaaccttgc tgattctgaa gtggataacc     2640

aaaaacgagg gaaacgacat tatgaagaaa aacaaaaaga acacttggat accttaaata     2700

aaaagaaacg agaactggat atgaaagaga aagaactaga ggagaaaatg tcacaagcaa     2760

gacaaatctg cccagagcgt atagaagtag aaaaatctgc atcaattctg gacaaagaaa     2820

ttaatcgatt aaggcagaag atacaggcag aacatgctag tcatggagat cgagaggaaa     2880

taatgaggca gtaccaagaa gcaagagaga cctatcttga tctggatagt aaagtgagga     2940

ctttaaaaaa gtttattaaa ttactgggag aaatcatgga gcacagattc aagacatatc     3000

aacaatttag aaggtgtttg actttacgat gcaaattata ctttgacaac ttactatctc     3060

agcgggccta ttgtggaaaa atgaattttg accacaagaa tgaaactcta agtatatcag     3120

ttcagcctgg agaaggaaat aaagctgctt tcaatgacat gagagccttg tctggaggtg     3180

aacgttcttt ctccacagtg tgttttattc tttccctgtg gtccatcgca gaatctcctt     3240

tcagatgcct ggatgaattt gatgtctaca tggatatggt taataggaga attgccatgg     3300

acttgatact gaagatggca gattcccagc gttttagaca gtttatcttg ctcacacctc     3360

aaagcatgag ttcacttcca tccagtaaac tgataagaat tctccgaatg tctgatcctg     3420

aaagaggaca aactacattg cctttcagac ctgtgactca agaagaagat gatgaccaaa     3480

ggtgatttgt aacttaacat gccttgtcct gatgttgaag gatttgtgaa gggaaaaaaa     3540

attctggact ctttgatata ataaaatgag actggaggca ttctgaaatg aaagaaactc     3600

ctttatatat ccaaccacaa tcaaacatat aaataagcct ggaaaaccaa ctacaacctg     3660

caatttaaga ttactattac tttaagaaaa tcaatttcat agtattggtt ttaaatcttt     3720

ttaagttttt ttaatacgat ctatttttat aggttctttt tcagaagtaa aattttgtac     3780

atatatacat gtacatatct gtttagtttg ggttcatttc tataacattt tgtaagaaaa     3840

taaaagtttg agcacctgat tatatttagt tttgcttttc cagatattac attctatagt     3900

taccaaaaat ggttgaaggg agggatttct cattgcagag ggtggggtgc aagggaataa     3960

gacacttgta cggaacactg aagctttgcc aacttctaca catgcctttt ttgcagtcct     4020

ttaactgtcc accctaccaa gagcttataa ccagtatcag aactggataa tgacgcagtt     4080

tttcactctg acctccatca tgcttgcctg atttaaaagc cctcagtttg cagtccaggg     4140

actgttcagg cttgtcctca gctgagagga cacaggctag agggactgtg cagaaccagg     4200

ctgggagaag ggctgggaaa actgggagtg gagggtggat cctcatggag caggagagta     4260

gctcatggct ccaggagcct gaggccatgc agttgatggt gagctgacat caattctaag     4320

actcatccta attgaggggt gttaaaaagt gtgctgctta gaatgaccaa atatagttat     4380

tgtaaaaaat gatatttatg aactttttat tttagaaaac atgaatttta ttgctccctg     4440

tattatttgt ttgatactag gattcatgct aaacttttta agaatgtatt ggatatcaag     4500

aagcattcct tacattagta gcaataaata ttagaataaa tatgaaattg aactattttc     4560

agaaaaaggg cagtatatta agagcaggga ctgttctcta gttattgagg aaaactggac     4620

tttgtttgtg tttttggtgg aggaagaagt ttaagatact ttagtcttaa attgaggttt     4680

gccaaatgag aagttcaaaa acttgggctt tctaatcaga atttccagga ggaggaaagt     4740

gtgtgctgaa tattttaaac atttcccact gatcatacaa agtctgattt ttaaatttac     4800

acttataatg cctttgtatt aaaattattt ttaacatgtg cttttccaaa ttaaaaatga     4860

agtagagtat accaaatgca taaactttca ttagctaagg aactcatgtc tgaattttgt     4920

tgtagttttg aatgttgtgc tctttcatac agaatgggaa acataatcct caggtatccc     4980

agcatctctt gttgaattga agattattca ttgctttggc ctcacaaagt tttgatttca     5040

actatcataa gtgaaaatat cttcctttaa tgttctaagt agtgataata ttactagaat     5100

gaaagaataa aaagaaattg ttcttttaaa atatgtgtaa cttctaaaaa taaaacttaa     5160

aatttatatg taaaaaaaaa aaaaaaaa                                        5188


<210>  423
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys 
1               5                   10                  15      


Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu 
            20                  25                  30          


Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile 
        35                  40                  45              


Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro 
    50                  55                  60                  


Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg 
                85                  90                  95      


Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp 
            100                 105                 110         


Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp 
        115                 120                 125             


Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln 
    130                 135                 140                 


His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr 
145                 150                 155                 160 


Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp 
                165                 170                 175     


His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu 
            180                 185                 190         


Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys 
        195                 200                 205             


Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser 
    210                 215                 220                 


Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly 
225                 230                 235                 240 


Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu 
                245                 250                 255     


Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu 
            260                 265                 270         


Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys 
        275                 280                 285             


Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala 
    290                 295                 300                 


Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu 
305                 310                 315                 320 


Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser 
                325                 330                 335     


Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp 
            340                 345                 350         


Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn 
        355                 360                 365             


Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu 
    370                 375                 380                 


Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu 
385                 390                 395                 400 


Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg 
                405                 410                 415     


Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu 
            420                 425                 430         


Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile 
        435                 440                 445             


Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Arg 
    450                 455                 460                 


Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe 
465                 470                 475                 480 


Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg 
                485                 490                 495     


Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile 
            500                 505                 510         


His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys 
        515                 520                 525             


Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val 
    530                 535                 540                 


Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro 
545                 550                 555                 560 


Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His 
                565                 570                 575     


Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu 
            580                 585                 590         


Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile 
        595                 600                 605             


Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met 
    610                 615                 620                 


Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp 
625                 630                 635                 640 


Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg 
                645                 650                 655     


Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu 
            660                 665                 670         


Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His 
        675                 680                 685             


Leu Ser Ala Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys 
    690                 695                 700                 


Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn 
705                 710                 715                 720 


Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val 
                725                 730                 735     


Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met 
            740                 745                 750         


Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His 
        755                 760                 765             


Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys 
    770                 775                 780                 


Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu 
785                 790                 795                 800 


Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg 
                805                 810                 815     


His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys 
            820                 825                 830         


Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser 
        835                 840                 845             


Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala 
    850                 855                 860                 


Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala 
865                 870                 875                 880 


Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln 
                885                 890                 895     


Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu 
            900                 905                 910         


Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys 
        915                 920                 925             


Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr 
    930                 935                 940                 


Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe 
945                 950                 955                 960 


Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly 
                965                 970                 975     


Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg 
            980                 985                 990         


Ser Phe Ser Thr Val Cys Phe Ile  Leu Ser Leu Trp Ser  Ile Ala Glu 
        995                 1000                 1005             


Ser Pro  Phe Arg Cys Leu Asp  Glu Phe Asp Val Tyr  Met Asp Met 
    1010                 1015                 1020             


Val Asn  Arg Arg Ile Ala Met  Asp Leu Ile Leu Lys  Met Ala Asp 
    1025                 1030                 1035             


Ser Gln  Arg Phe Arg Gln Phe  Ile Leu Leu Thr Pro  Gln Ser Met 
    1040                 1045                 1050             


Ser Ser  Leu Pro Ser Ser Lys  Leu Ile Arg Ile Leu  Arg Met Ser 
    1055                 1060                 1065             


Asp Pro  Glu Arg Gly Gln Thr  Thr Leu Pro Phe Arg  Pro Val Thr 
    1070                 1075                 1080             


Gln Glu  Glu Asp Asp Asp Gln  Arg 
    1085                 1090     


<210>  424
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  424
tgcctcattc tagagaatgg gcactgttga tcatggtgtc caaaaatagt taatgtggct       60

aaattgagac aggttatgct tccatcacag tatgcatatt gcagtggtga caatgagacc      120

tgtaacattt                                                             130


<210>  425
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  425
gttgaggtct atcccgatgg ggcttttcct gtagcctgca catcgttgga aacgcctcat       60

agagtaactc tgtggtttta ctttactcac aggactattg ttagatctgt gggaaggaat      120

tacaagacag tt                                                          132


<210>  426
<211>  128
<212>  DNA
<213>  Homo sapiens

<400>  426
gtgcacattt cattgacctg ctttctttta tgtgagtagt gttatttctt atgtgctata       60

caaataattg aaggctaatt agcagtataa ctataaatag taatgctgcc agtctccttc      120

agacaaaa                                                               128


<210>  427
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  427
atcgaggcta gagtcacgct tgggtatcgg ctattgcctg agtgtgctag agtcctcgaa       60

gagtaactgc tgaccttatt cactggctgt gggccttatg gcacagtcag tcaccaggtt      120

agagacatgc                                                             130


<210>  428
<211>  121
<212>  DNA
<213>  Homo sapiens

<400>  428
tggtcattac caaggctttt agaatgcagt ttctcatttg ctgtggacat gaccataaaa       60

aaatttccca gtaggttttc tatctgctac tttgctagca atcagcttat tgggaacagt      120

t                                                                      121


<210>  429
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  429
tcctcctaca aaggcgtgtc tgtggttccc tgtctttgga cacgtaagaa ttggaggaaa       60

ataaatgtgg atttgggaaa ctttgaggcc agcttgcttc ttgcaggctc atgatcaacc      120

aatctcacat aa                                                          132


<210>  430
<211>  127
<212>  DNA
<213>  Homo sapiens

<400>  430
tgcacttatg tatgtttttg tttaacgtgg acaaagactt acagataggt gcaaaaaata       60

aatcctcttt tgcaacccag aactcattgt tcagtatgag ttttgataca tataagaagg      120

gatatta                                                                127


<210>  431
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  431
gccgagacta gagtcacatc ctgacacaac tcttgtcctg gtgtgctaga gtactcgaag       60

agaatctact ggtcttgatt cactggtggg ggcagtcggt gcccccgtta gtgcccagat      120

cagaaacata c                                                           131


<210>  432
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  432
gagcactgtt cgtaacccgt tagcctggct gtagctaatg ggttccattc cggtgcaata       60

gcatttccag cgacacatga ctgactgact ggtggctttc agtttcaggt cttggagaca      120

aat                                                                    123


<210>  433
<211>  149
<212>  DNA
<213>  Homo sapiens

<400>  433
tgcacactat taaagctcag ggtggaggcc agtcttggct catgaacttc tgagtgtcgg       60

aagtgtgcta tatcaatggc aggattttcg ctaacaccag tagagcttgc ctctatgact      120

ggagtttggt agtactcgct gccacatag                                        149


<210>  434
<211>  154
<212>  DNA
<213>  Homo sapiens

<400>  434
tgtgcacatt gttagagctt ggagttgagg ctactgactg gccgatgaac tcgcaagtgt       60

aggtagtgtg ctacatgagg ggcaagtttt cgctaacacc acaagggtct ctggcccaat      120

gagtggagtt tgatagtaat tcttgctaca agta                                  154


<210>  435
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  435
gcgctgtctt tgagcccccg ccgagcttcc tcgtggcgcc gggggtcaat ctgcagcgct       60

agagcatgtg cttgcgcata actggggccg cctggcctcc cgcgggcggc ctttttaacc      120

gcgagcgaca aga                                                         133


<210>  436
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  436
tgcactgcat ggtatctgca ctcagcagtt tacacctgct agggtgttca aaggtcagtg       60

ctatagaaat tcagtatctg gcatcgttgg ttttcttggc tttgtgcttg ttaaacctgg      120

tatttctact gatacagta                                                   139


<210>  437
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  437
gccctgtggt tgctggatgc tgttgtgcat ggacagctct ccagtggatt cgatgggcca       60

tagcaatcct gtgatttatg catggaggct gcttctcctc agcagctgcc atagcccggt      120

cgctggtaca tga                                                         133


<210>  438
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  438
tgcaatgatg tcgtaatttg cgtcttactc tgttctcagc gacagttgcc tgctgtcagt       60

aagctggtac agaaggttga cgaaaattct tactgagcaa                            100


<210>  439
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  439
cagtagtgat gaaattccac ttcattggtc cgtgtttctg aaccacatga ttttctcgga       60

tgttctgatg                                                              70


<210>  440
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  440
tcaaaatgat gagattccac ttaattggtc cgtgtttctg aaacacatga tatttgtgga       60

aattctgact                                                              70


<210>  441
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  441
ttgttatgat gagattccac ttaaggtccg tgtttctgaa acaaatgatt ttgtggaagt       60

tctgatt                                                                 67


<210>  442
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  442
tgcagatgat gtaaaagaat atttgctatc tgagagatgg tgatgacatt ttaaaccacc       60

aagatcgctg atgca                                                        75


<210>  443
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  443
tggcagatga tgtttgtttt cacgatggtc ttcagatgcc cacgtgggca ctgctgagaa       60

agccacttgg taaaactgat gccggaaa                                          88


<210>  444
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  444
ttgcaatgat gtgaatctct cactgaattc aaccttgaag tgcgaatcca tgagcttttt       60

aaccctgagc aa                                                           72


<210>  445
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  445
gttgcagtga tgtaaaattt cttggcctga aattactgtg aagagtaaaa ccgagctttt       60

taacactgag t                                                            71


<210>  446
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  446
ttgccaatga tggttaagaa tttcttcacc tgaataaacc atgtggtcag cattgcatct       60

gaggcaaa                                                                68


<210>  447
<211>  217
<212>  DNA
<213>  Homo sapiens

<400>  447
aagactatac tttcagggat catttctata gtgtgttact agagaagttt ctctgaacgt       60

gtagagcacc gaaaaccccg aggaagagag gtagcgtttt ctcctgagcg tgaagccggc      120

tttctggcgt tgcttggctg caactgccgt cagccattga tgatcgttct tctctccgta      180

ttggggagtg agagggagag aacgcggtct gagtggt                               217


<210>  448
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  448
cacagatgat gaacttattg acgggcggac agaaactgtg tgctgattgt cacgttctga       60

tt                                                                      62


<210>  449
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  449
cctggatgat gataagcaaa tgctgactga acatgaaggt cttaattagc tctaactgac       60

t                                                                       61


<210>  450
<211>  77
<212>  DNA
<213>  Homo sapiens

<400>  450
aaccaatgat gtaatgattc tgccaaatga aatataatga tatcactgta aaaccgttcc       60

attttgattc tgaggtt                                                      77


<210>  451
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  451
gttcagatga tgaatttaac tgttcaactg ctgaatgata acgggcatga actaaaactt       60

aattctgaca gag                                                          73


<210>  452
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  452
ctgcagtgat gactttctta ggacaccttt ggatttaccg tgaaaattaa taaattctga       60

gcagc                                                                   65


<210>  453
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  453
gatgttatga tgatgggcga aatgttcaac tgctctgaag gggctgaatg aaaatggcct       60

ttctgaacat c                                                            71


<210>  454
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  454
agtctgtgat gaattgcttt gacttctgac acctcgtatg aaaactgcac gtgcagtctg       60

attatttagc aagactgagg ctt                                               83


<210>  455
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  455
gctatgatga atttgattgc attgatcgtc tgacatgata atgtattttt gtcctctaag       60

aagttctgag ctt                                                          73


<210>  456
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  456
ctgcctctga tgaagcctgt gttggtaggg acatctgaca gtaatgatga atgccaaccg       60

ctctgatggt gg                                                           72


<210>  457
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  457
agcctgtgat gctttaagag tagtggacag aagggatttc tgaaattcta ttctgaggct       60


<210>  458
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  458
tgccacaatg atgacagttt atttgctact cttgagtgct agaatgatga ggatcttaac       60

caccattatc ttaactgagg c                                                 81


<210>  459
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  459
cagatactat gatggttgca tagttcagca gatttaatca tgaagagatg tactatctgt       60

c                                                                       61


<210>  460
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  460
gtgtaatgat gttgatcaaa tgtctgacct gaaatgagca tgtagacaaa ggta             54


<210>  461
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  461
acaatgatga taacatagtt cagcagacta acgctgatga gcaatattaa gtctttcgct       60

cctatctgat g                                                            71


<210>  462
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  462
tacatgatga tctcaatcca acttgaactc tctcactgat tac                         43


<210>  463
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  463
gctgttcgtt gatgaggctc agagtgagcg ctgggtacag cgcccgaatc ggacagtgta       60

gaaccattct ctactgcctt ccttctgaga acagc                                  95


<210>  464
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  464
gctgttcagt gatgaggcct ggaatgtgcg ctgggcacag cgcccgagac agactgcgga       60

accgttcctt gttgccttcc ttctgagaac agc                                    93


<210>  465
<211>  866
<212>  DNA
<213>  Homo sapiens

<400>  465
agcttcaatg gaaggaggga gccaagaagg gggcctggta tacattcaaa gatgataatt       60

acgacatgga ttgtgtatat tcttgctcgg aaaggtgtag ggcttccctt cctaccaata      120

accagttcgg acattgacgt tgtggaaagt gaggctgtgt ctgtactaca tcattggttg      180

aaaaaaacag aagaagaggc ttctcggggc ataaaggaaa agctgtccat caaccaccct      240

tcccagggtg taagggagaa gatgtccact gactcccctc ccacccatgg ccaggacatc      300

cacgtgacca gagatgtggt gaagcaccac ctctctaagt ctgatttgtt ggcaaaccag      360

agccaagagg tcctagagga gagaacacga atccagttca taagatggag ccacactcgt      420

atcttccaag tgccaagtga gatgacagag gacatcatgc gagatcgaat agagcaggtg      480

agacgaagca tatcccgtct tacagatgtc tcagctcagg acttcagtat gagaccctcc      540

tcctcagact gctgagagca acagatggag ctttgggaac gcggagaaca gtggggttac      600

agggagtcat catcagccct accccttggc caaccacatc tccctgctgt gtcccctggg      660

catttctcta cctcccaggt ggaagtcctt cagggtccag cagcaacctg tatcagaaga      720

acatccttct ctgcttgacc tgaagaaggg ccagacctgg gcagaaagac tccagcaggt      780

gagctcttca tgcgacagtg tcagcactgg agtcttcttg ctgaactgcg aataaagaga      840

tgtgctgttt aacaacccgc cctgtt                                           866


<210>  466
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Ile Ile Thr Thr Trp Ile Val Tyr Ile Leu Ala Arg Lys Gly Val 
1               5                   10                  15      


Gly Leu Pro Phe Leu Pro Ile Thr Ser Ser Asp Ile Asp Val Val Glu 
            20                  25                  30          


Ser Glu Ala Val Ser Val Leu His His Trp Leu Lys Lys Thr Glu Glu 
        35                  40                  45              


Glu Ala Ser Arg Gly Ile Lys Glu Lys Leu Ser Ile Asn His Pro Ser 
    50                  55                  60                  


Gln Gly Val Arg Glu Lys Met Ser Thr Asp Ser Pro Pro Thr His Gly 
65                  70                  75                  80  


Gln Asp Ile His Val Thr Arg Asp Val Val Lys His His Leu Ser Lys 
                85                  90                  95      


Ser Asp Leu Leu Ala Asn Gln Ser Gln Glu Val Leu Glu Glu Arg Thr 
            100                 105                 110         


Arg Ile Gln Phe Ile Arg Trp Ser His Thr Arg Ile Phe Gln Val Pro 
        115                 120                 125             


Ser Glu Met Thr Glu Asp Ile Met Arg Asp Arg Ile Glu Gln Val Arg 
    130                 135                 140                 


Arg Ser Ile Ser Arg Leu Thr Asp Val Ser Ala Gln Asp Phe Ser Met 
145                 150                 155                 160 


Arg Pro Ser Ser Ser Asp Cys 
                165         


<210>  467
<211>  2206
<212>  DNA
<213>  Homo sapiens

<400>  467
gagccgcgta gaaggaacgc ggcggtgtgc cccggaagcg gaagtagatt ctcctataga       60

aaggctggac tacgcggagt ggtgacgttt cctcattggg cggaaggttc gctggcactc      120

cgttggtctt ccagctggtg ggagttgacg acgtggtgct gggcgttggg accctacttt      180

atctagttcg ggaagttggg ttgtggggtc atacctgtct gtctgctccc agctttcttg      240

ggtttcttcc gacggcgtgg ggcctcgcta aggaattccc ggcccctcag ggccacggct      300

ttagcggtgt cttttgcgag ttcttcgtaa gtacatctta aagctgtcaa gatggttcta      360

gcagaccttg gaagaaaaat aacatcagca ttacgctcgt tgagcaatgc caccattatc      420

aatgaagagg tctgctattg atcttgaaga gatggcatct ggtcttaaca aaagaaaaat      480

gattcagcat gctgtattta aagaacttgt gaagcttgta gaccctggag ttaaggcatg      540

gacacccact aaaggaaaac aaaatgtgat tatgtttgtt ggattgcaag ggagtggtaa      600

aacaacaaca tgttcaaagc tagcatatta ttaccagagg aaaggttgga agacctgttt      660

aatatgtgca gacacattca gagcaggggc ttttgaccaa ctaaaacaga atgctaccaa      720

agcaagaatt ccattttatg gaagctatac agaaatggat cctgtcatca ttgcttctga      780

aggagtagag aaatttaaaa atgaaaattt tgaaattatt attgttgata caagtggccg      840

ccacaaacaa gaagactctt tgtttgaaga aatgcttcaa gttgctaatg ctatacaacc      900

tgataacatt gtttatgtga tggatgcctc cattgggcag gcttgtgaag cccaggctaa      960

ggcttttaaa gataaagtag atgtagcctc agtaatagtg acaaaacttg atggccatgc     1020

aaaaggaggt ggtgcactca gtgcagtcgc tgccacaaaa agtccgatta ttttcattgg     1080

tacaggggaa catatagatg actttgaacc tttcaaaaca cagcctttta ttagcaaact     1140

tcttggtatg ggcgacattg aaggactgat agataaagtc aacgagttga agttggatga     1200

caatgaagca cttatagaga agttgaaaca tggtcagttt acgttgcgag acatgtatga     1260

gcaatttcaa aatatcatga aaatgggccc cttcagtcag atcttgggga tgatccctgg     1320

ttttgggaca gattttatga gcaaaggaaa tgaacaggag tcaatggcaa ggctaaagaa     1380

attaatgaca ataatggata gtatgaatga tcaagaacta gacagtacgg atggtgccaa     1440

agtttttagt aaacaaccag gaagaatcca aagagtagca agaggatcgg gtgtatcaac     1500

aagagatgtt caagaacttt tgacacaata taccaagttt gcacagatgg taaaaaagat     1560

gggaggtatc aaaggacttt tcaaaggtgg cgacatgtct aagaatgtga gccagtcaca     1620

gatggcaaaa ttgaaccaac aaatggccaa aatgatggat cctagggttc ttcatcacat     1680

gggtggtatg gcaggacttc agtcaatgat gaggcagttt caacagggtg ctgctggcaa     1740

catgaaaggc atgatgggat tcaataatat gtaaagaaaa tgccttaata taaactgact     1800

cagttgaata cctaatttgc tgagacctca gcgtttccct tctttttgcg aattgggggg     1860

aaagtgtatt tttcttgctt atcatgcact ctttcctttt cttctcgccc gcttttcccc     1920

tccttttctt tttccttcct tctttcctcc ctttaatata agggagaaat acatggtttt     1980

tgtggaaatc attatatgtt tgctttagat tttcttctgt tttcaccatc ataacactta     2040

agttaaatca tgatgtaaaa ttttagtact taaaggtttt taattatctc gaaggccaag     2100

cattgcattt gtaaacagtc ctggtcagta gttaaataat gtttcaatta aagtgctgta     2160

aaataaactt caaagtggtt ataagttaaa aaaaaaaaaa aaaaaa                    2206


<210>  468
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Pro Pro Leu Ser Met Lys Arg Ser Ala Ile Asp Leu Glu Glu Met 
1               5                   10                  15      


Ala Ser Gly Leu Asn Lys Arg Lys Met Ile Gln His Ala Val Phe Lys 
            20                  25                  30          


Glu Leu Val Lys Leu Val Asp Pro Gly Val Lys Ala Trp Thr Pro Thr 
        35                  40                  45              


Lys Gly Lys Gln Asn Val Ile Met Phe Val Gly Leu Gln Gly Ser Gly 
    50                  55                  60                  


Lys Thr Thr Thr Cys Ser Lys Leu Ala Tyr Tyr Tyr Gln Arg Lys Gly 
65                  70                  75                  80  


Trp Lys Thr Cys Leu Ile Cys Ala Asp Thr Phe Arg Ala Gly Ala Phe 
                85                  90                  95      


Asp Gln Leu Lys Gln Asn Ala Thr Lys Ala Arg Ile Pro Phe Tyr Gly 
            100                 105                 110         


Ser Tyr Thr Glu Met Asp Pro Val Ile Ile Ala Ser Glu Gly Val Glu 
        115                 120                 125             


Lys Phe Lys Asn Glu Asn Phe Glu Ile Ile Ile Val Asp Thr Ser Gly 
    130                 135                 140                 


Arg His Lys Gln Glu Asp Ser Leu Phe Glu Glu Met Leu Gln Val Ala 
145                 150                 155                 160 


Asn Ala Ile Gln Pro Asp Asn Ile Val Tyr Val Met Asp Ala Ser Ile 
                165                 170                 175     


Gly Gln Ala Cys Glu Ala Gln Ala Lys Ala Phe Lys Asp Lys Val Asp 
            180                 185                 190         


Val Ala Ser Val Ile Val Thr Lys Leu Asp Gly His Ala Lys Gly Gly 
        195                 200                 205             


Gly Ala Leu Ser Ala Val Ala Ala Thr Lys Ser Pro Ile Ile Phe Ile 
    210                 215                 220                 


Gly Thr Gly Glu His Ile Asp Asp Phe Glu Pro Phe Lys Thr Gln Pro 
225                 230                 235                 240 


Phe Ile Ser Lys Leu Leu Gly Met Gly Asp Ile Glu Gly Leu Ile Asp 
                245                 250                 255     


Lys Val Asn Glu Leu Lys Leu Asp Asp Asn Glu Ala Leu Ile Glu Lys 
            260                 265                 270         


Leu Lys His Gly Gln Phe Thr Leu Arg Asp Met Tyr Glu Gln Phe Gln 
        275                 280                 285             


Asn Ile Met Lys Met Gly Pro Phe Ser Gln Ile Leu Gly Met Ile Pro 
    290                 295                 300                 


Gly Phe Gly Thr Asp Phe Met Ser Lys Gly Asn Glu Gln Glu Ser Met 
305                 310                 315                 320 


Ala Arg Leu Lys Lys Leu Met Thr Ile Met Asp Ser Met Asn Asp Gln 
                325                 330                 335     


Glu Leu Asp Ser Thr Asp Gly Ala Lys Val Phe Ser Lys Gln Pro Gly 
            340                 345                 350         


Arg Ile Gln Arg Val Ala Arg Gly Ser Gly Val Ser Thr Arg Asp Val 
        355                 360                 365             


Gln Glu Leu Leu Thr Gln Tyr Thr Lys Phe Ala Gln Met Val Lys Lys 
    370                 375                 380                 


Met Gly Gly Ile Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys Asn 
385                 390                 395                 400 


Val Ser Gln Ser Gln Met Ala Lys Leu Asn Gln Gln Met Ala Lys Met 
                405                 410                 415     


Met Asp Pro Arg Val Leu His His Met Gly Gly Met Ala Gly Leu Gln 
            420                 425                 430         


Ser Met Met Arg Gln Phe Gln Gln Gly Ala Ala Gly Asn Met Lys Gly 
        435                 440                 445             


Met Met Gly Phe Asn Asn Met 
    450                 455 


<210>  469
<211>  2298
<212>  DNA
<213>  Homo sapiens

<400>  469
gagccgcgta gaaggaacgc ggcggtgtgc cccggaagcg gaagtagatt ctcctataga       60

aaggctggac tacgcggagt ggtgacgttt cctcattggg cggaaggttc gctggcactc      120

cgttggtctt ccagctggtg ggagttgacg acgtggtgct gggcgttggg accctacttt      180

atctagttcg ggaagttggg ttgtggggtc atacctgtct gtctgctccc agctttcttg      240

ggtttcttcc gacggcgtgg ggcctcgcta aggaattccc ggcccctcag ggccacggct      300

ttagcggtgt cttttgcgag ttcttcgtaa gtacatctta aagctgtcaa gatggttcta      360

gcagaccttg gaagaaaaat aacatcagca ttacgctcgt tgagcaatgc caccattatc      420

aatgaagagg tattgaatgc tatgctaaaa gaagtctgta ccgctttgtt ggaagcagat      480

gttaatatta aactagtgaa gcaactaaga gaaaatgtta agtctgctat tgatcttgaa      540

gagatggcat ctggtcttaa caaaagaaaa atgattcagc atgctgtatt taaagaactt      600

gtgaagcttg tagaccctgg agttaaggca tggacaccca ctaaaggaaa acaaaatgtg      660

attatgtttg ttggattgca agggagtggt aaaacaacaa catgttcaaa gctagcatat      720

tattaccaga ggaaaggttg gaagacctgt ttaatatgtg cagacacatt cagagcaggg      780

gcttttgacc aactaaaaca gaatgctacc aaagcaagaa ttccatttta tggaagctat      840

acagaaatgg atcctgtcat cattgcttct gaaggagtag agaaatttaa aaatgaaaat      900

tttgaaatta ttattgttga tacaagtggc cgccacaaac aagaagactc tttgtttgaa      960

gaaatgcttc aagttgctaa tgctatacaa cctgataaca ttgtttatgt gatggatgcc     1020

tccattgggc aggcttgtga agcccaggct aaggctttta aagataaagt agatgtagcc     1080

tcagtaatag tgacaaaact tgatggccat gcaaaaggag gtggtgcact cagtgcagtc     1140

gctgccacaa aaagtccgat tattttcatt ggtacagggg aacatataga tgactttgaa     1200

cctttcaaaa cacagccttt tattagcaaa cttcttggta tgggcgacat tgaaggactg     1260

atagataaag tcaacgagtt gaagttggat gacaatgaag cacttataga gaagttgaaa     1320

catggtcagt ttacgttgcg agacatgtat gagcaatttc aaaatatcat gaaaatgggc     1380

cccttcagtc agatcttggg gatgatccct ggttttggga cagattttat gagcaaagga     1440

aatgaacagg agtcaatggc aaggctaaag aaattaatga caataatgga tagtatgaat     1500

gatcaagaac tagacagtac ggatggtgcc aaagttttta gtaaacaacc aggaagaatc     1560

caaagagtag caagaggatc gggtgtatca acaagagatg ttcaagaact tttgacacaa     1620

tataccaagt ttgcacagat ggtaaaaaag atgggaggta tcaaaggact tttcaaaggt     1680

ggcgacatgt ctaagaatgt gagccagtca cagatggcaa aattgaacca acaaatggcc     1740

aaaatgatgg atcctagggt tcttcatcac atgggtggta tggcaggact tcagtcaatg     1800

atgaggcagt ttcaacaggg tgctgctggc aacatgaaag gcatgatggg attcaataat     1860

atgtaaagaa aatgccttaa tataaactga ctcagttgaa tacctaattt gctgagacct     1920

cagcgtttcc cttctttttg cgaattgggg ggaaagtgta tttttcttgc ttatcatgca     1980

ctctttcctt ttcttctcgc ccgcttttcc cctccttttc tttttccttc cttctttcct     2040

ccctttaata taagggagaa atacatggtt tttgtggaaa tcattatatg tttgctttag     2100

attttcttct gttttcacca tcataacact taagttaaat catgatgtaa aattttagta     2160

cttaaaggtt tttaattatc tcgaaggcca agcattgcat ttgtaaacag tcctggtcag     2220

tagttaaata atgtttcaat taaagtgctg taaaataaac ttcaaagtgg ttataagtta     2280

aaaaaaaaaa aaaaaaaa                                                   2298


<210>  470
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Val Leu Ala Asp Leu Gly Arg Lys Ile Thr Ser Ala Leu Arg Ser 
1               5                   10                  15      


Leu Ser Asn Ala Thr Ile Ile Asn Glu Glu Val Leu Asn Ala Met Leu 
            20                  25                  30          


Lys Glu Val Cys Thr Ala Leu Leu Glu Ala Asp Val Asn Ile Lys Leu 
        35                  40                  45              


Val Lys Gln Leu Arg Glu Asn Val Lys Ser Ala Ile Asp Leu Glu Glu 
    50                  55                  60                  


Met Ala Ser Gly Leu Asn Lys Arg Lys Met Ile Gln His Ala Val Phe 
65                  70                  75                  80  


Lys Glu Leu Val Lys Leu Val Asp Pro Gly Val Lys Ala Trp Thr Pro 
                85                  90                  95      


Thr Lys Gly Lys Gln Asn Val Ile Met Phe Val Gly Leu Gln Gly Ser 
            100                 105                 110         


Gly Lys Thr Thr Thr Cys Ser Lys Leu Ala Tyr Tyr Tyr Gln Arg Lys 
        115                 120                 125             


Gly Trp Lys Thr Cys Leu Ile Cys Ala Asp Thr Phe Arg Ala Gly Ala 
    130                 135                 140                 


Phe Asp Gln Leu Lys Gln Asn Ala Thr Lys Ala Arg Ile Pro Phe Tyr 
145                 150                 155                 160 


Gly Ser Tyr Thr Glu Met Asp Pro Val Ile Ile Ala Ser Glu Gly Val 
                165                 170                 175     


Glu Lys Phe Lys Asn Glu Asn Phe Glu Ile Ile Ile Val Asp Thr Ser 
            180                 185                 190         


Gly Arg His Lys Gln Glu Asp Ser Leu Phe Glu Glu Met Leu Gln Val 
        195                 200                 205             


Ala Asn Ala Ile Gln Pro Asp Asn Ile Val Tyr Val Met Asp Ala Ser 
    210                 215                 220                 


Ile Gly Gln Ala Cys Glu Ala Gln Ala Lys Ala Phe Lys Asp Lys Val 
225                 230                 235                 240 


Asp Val Ala Ser Val Ile Val Thr Lys Leu Asp Gly His Ala Lys Gly 
                245                 250                 255     


Gly Gly Ala Leu Ser Ala Val Ala Ala Thr Lys Ser Pro Ile Ile Phe 
            260                 265                 270         


Ile Gly Thr Gly Glu His Ile Asp Asp Phe Glu Pro Phe Lys Thr Gln 
        275                 280                 285             


Pro Phe Ile Ser Lys Leu Leu Gly Met Gly Asp Ile Glu Gly Leu Ile 
    290                 295                 300                 


Asp Lys Val Asn Glu Leu Lys Leu Asp Asp Asn Glu Ala Leu Ile Glu 
305                 310                 315                 320 


Lys Leu Lys His Gly Gln Phe Thr Leu Arg Asp Met Tyr Glu Gln Phe 
                325                 330                 335     


Gln Asn Ile Met Lys Met Gly Pro Phe Ser Gln Ile Leu Gly Met Ile 
            340                 345                 350         


Pro Gly Phe Gly Thr Asp Phe Met Ser Lys Gly Asn Glu Gln Glu Ser 
        355                 360                 365             


Met Ala Arg Leu Lys Lys Leu Met Thr Ile Met Asp Ser Met Asn Asp 
    370                 375                 380                 


Gln Glu Leu Asp Ser Thr Asp Gly Ala Lys Val Phe Ser Lys Gln Pro 
385                 390                 395                 400 


Gly Arg Ile Gln Arg Val Ala Arg Gly Ser Gly Val Ser Thr Arg Asp 
                405                 410                 415     


Val Gln Glu Leu Leu Thr Gln Tyr Thr Lys Phe Ala Gln Met Val Lys 
            420                 425                 430         


Lys Met Gly Gly Ile Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys 
        435                 440                 445             


Asn Val Ser Gln Ser Gln Met Ala Lys Leu Asn Gln Gln Met Ala Lys 
    450                 455                 460                 


Met Met Asp Pro Arg Val Leu His His Met Gly Gly Met Ala Gly Leu 
465                 470                 475                 480 


Gln Ser Met Met Arg Gln Phe Gln Gln Gly Ala Ala Gly Asn Met Lys 
                485                 490                 495     


Gly Met Met Gly Phe Asn Asn Met 
            500                 


<210>  471
<211>  6801
<212>  DNA
<213>  Homo sapiens

<400>  471
cagggggagc accgagcacc acggtgtcgt gcgcttcgag gcgcggcgtg ggaagaaggc       60

tggttcattc tgccacccat ctgcattaag acacaaggtg ctgaccgcag agacctgcca      120

tgaaaccaca cttgaagcaa tggagacaac gaatgctttt cggaatattc gcttgggggc      180

tcctcttttt gctgattttc atctacttca ccgacagcaa ccccgctgag cctgtaccca      240

gctccctctc cttcctggag accaggaggc tcctgccggt gcaggggaag cagcgggcca      300

tcatgggcgc cgcacatgag ccctccccgc ctgggggcct ggacgcacgc caggcgctgc      360

cccgcgccca cccagccggt tcctttcatg cggggcctgg agacctgcag aaatgggccc      420

agtcccaaga tgggtttgaa cataaagagt ttttttcatc ccaggtgggg agaaaatctc      480

aaagtgcttt ctacccggag gatgacgact acttttttgc tgctggtcag ccagggtggc      540

acagccacac tcaggggaca ttgggattcc cttcccccgg ggagccaggc ccacgggagg      600

gggcttttcc ggctgcacag gtccagagga ggcgggtgaa gaagaggcac cggaggcaga      660

gaaggagcca cgtgttggag gagggcgacg acggcgacag gctgtactcc tccatgtcca      720

gggccttcct gtaccggctc tggaagggga acgtctcttc caaaatgctg aacccgcgcc      780

tgcagaaggc gatgaaggat tacctgaccg ccaacaagca cggggtgcgc ttccgcggga      840

agcgggaggc cgggctgagc agggcacagc tgctgtgcca gctgcggagc cgcgcgcgcg      900

tgcggacgct ggacggcacc gaggcgccct tttctgcgct gggctggcgg cgcctggtgc      960

ccgccgtgcc cctgagccag ctgcaccccc gcggcctgcg cagctgcgct gtcgtcatgt     1020

ctgcaggcgc aatcctcaac tcttccttgg gcgaggaaat agattctcat gatgcggttt     1080

tgagatttaa ctctgctcct acacgtggtt atgagaaaga tgttgggaat aaaaccacca     1140

tacgcatcat taattcgcag attctgacca accccagcca tcacttcatt gacagttcac     1200

tgtataaaga cgtcattttg gtggcctggg accctgcccc atattccgca aatcttaacc     1260

tgtggtacaa aaaaccggat tacaacctgt tcactccata tattcagcat cgtcagagaa     1320

acccaaatca gccattttac attcttcatc ctaaatttat atggcagctc tgggatatta     1380

tccaggagaa cactaaagag aagattcaac caaacccacc atcttctggt ttcattggaa     1440

tcctcataat gatgtccatg tgcagagagg tgcacgtgta tgaatatatc ccatccgtgc     1500

ggcagacgga gctgtgccac taccacgagc tgtactacga cgcagcctgc accctcgggg     1560

cgtaccaccc actactctat gagaagctcc tggtgcagcg cctgaacatg ggcacgcagg     1620

gggatttgca tcgcaagggc aaggtggttc ttcccggctt ccaggcggtg cactgccctg     1680

caccaagtcc agtcattcca cactcttaaa aagggtttct tgggaatcaa tgtgcaataa     1740

ggtactactg ttgtactcaa agtcacaaaa gaatacttga agatagattt tagacagtgt     1800

agttttgagt ctttaaacag taatttagtg gtggtcatga taatccttct ctttctaagc     1860

cattgagtat gtattactgc tttgaacata gaaatggttt ttttaaaaaa ataaggctca     1920

agaaagatgc aaaaccaagg atagctagaa agaaaacaca tgtatgacca tgggtatgat     1980

acctccagaa atgttaacaa cttattcttc tgccatgagt acccctcatc agggttggtt     2040

tcaatgacag gttttggtga tgttcctgac catatgaagt ggtttatgtt tagaaacatt     2100

caaattgagg gacatcattt acagcatcga gtgtgtcagt tatacatgca ttcatcatta     2160

aatatcctag gttttatgac agacattgaa attatcactc agatgtgttt aacagcaaaa     2220

aattcccagc acatcctggc aaaggctttt atttccaacc gttgcattct tcatctctgc     2280

ctcccattgc ccactgaatg ctttgctttc tgtgcatcaa gacagagttc taaaaccaga     2340

aaacatccat cttgaaaggt ccaagaaaaa gccaaattcc atatagcacc acagaggagg     2400

ccctttgttt ccctgcagta tttcaaccag gaacattagt atcacatcca ccaggaggca     2460

catcactggc aagtaacata gaatcacagg gctgcaggtg cccctggaca ctccccggtt     2520

ctggcttttc tgccttgtac ctcctcacct gcagatctac cctgcagctt ttgcatagtc     2580

agtgacacac ttgacaattg gcacagctgt gctggggaag acgggagaca ccttgctcct     2640

tccaaactag aaggaaagat tttggagcca tcaccctgtg cttctaggga tgcacgcctg     2700

tctttattat acaggtttct tgcaggtttt tatcagccag tgggaactcc acagtgatga     2760

gcactgaatc ttcactaaat cttcctacag acatttagga atccagtcct tgcttttgca     2820

gatatgtttt atgtcagcag catgacaaag ccatataatt aaataattta tgtgaaagca     2880

ttgcttatta acaaggaaaa tatgtagatg cttcagaggg aaaggcagct agagggaaat     2940

tttcatccca atatgttagc tatattcagg gttgattttt tctttaatct caactgtcac     3000

tgatacattg aaaaattttt gctatgaata tagtgaaaca gaaacattct gtaatacctt     3060

aattaaacat gctattattt caatgtataa ccaaaacata tctccatggt acagttaaga     3120

cttgttgcaa tgacaatagc agcttaatta aatgcgttct cccttgcaaa atgtatgaat     3180

gtcaggagag tttagtggaa aagttttctt tgtttcagga ttggtttctt ctagactgtt     3240

ctcaggacta ctttcttgag caagaatggc ttacagagac tgaaggcttc tgtttggtta     3300

gtctattcag cagatatgga gctggaaaac aagacatctc ctatagcttg ctataatagt     3360

gaaggagaaa ttggaaagtt ttaatcacaa taatatccaa taaaagccca ttttgagagt     3420

tttgttatta agtcaatgag aagggatagg taactttgtc ctatatatta acttatgtct     3480

aaatagacat ggttaagcca tgttcctttc taatttcttt tcttttcttt tttttttttt     3540

tttttgagac agtctctcgc tctgtcgccc aggctagagt gcagtggtgc gatcttggtt     3600

cactgccagc tctgcctccc acgttcacac cattctcctg cctcagcctc ctgagtagct     3660

ggggactaca ggcacccgcc accacgccca gctaattttt tgtattttta gtagagacag     3720

ggtttcaccg tgttagccag ggtggtctcg atctcctgac cttgtgatct gcctgcctcg     3780

gcctcccaaa gtgatgggat tataggcgtg agccaccacc gcgcccggtc attcctttct     3840

aatttcttga aaaaactttg tcttgtcctt atgtttacat gtgtgtaata atttcagcaa     3900

ctctggaatg tgggtgaggt ggctgtggtg gatgaatatt actccctacc ctccttggat     3960

ctttctagat cttccagacc attaaatgcc cctgaagctc cttttatagt tttgcaagtg     4020

gatttacttg tagacatcct tactatccag cataatcccc cttggctgac atgagaactt     4080

ggttagagga gaatttattg gggtcagtgt aaatattcaa gttcaaaagc ctcagaaccc     4140

aacactttaa agatttttaa atggaatttt gtcgtagtca ttgtactttt aaaatagtac     4200

tttcagtttc attgaggtta caagaaagac tgaagagtac aaaggaaatt tagttacaat     4260

ttttgcattt attatggcct taaagactct tgggaatcag gctctgttca acagtcaata     4320

aatgtaatac acacattaat atagtactga ctgggcgttc ttctataaaa gtttaagttc     4380

tttggcttct aagaaaatgt tgggcagtta cagttaactt gatgactact tctagtatta     4440

gccaaatggg tcctaagtgg cagcattttg ccagacattg actaaatcct tacatgccac     4500

atttactgaa ttccaataaa catatagttc ttctgtggag tagttaacag taagtggcag     4560

ctcactgaat ttctcccagg ttctgtctct tccaaaatcc tccatcctct cttatgaagg     4620

gaagctgata aaaaaaaatc ctcttggtgc aagctgaagc tgttaaggat tccttttttc     4680

actctcagga ccaacagacg ttcttttgta tttcaagata atttcacctg ttgttgttgt     4740

tgttgttgtt gttgttgttg ttgttgttgt tgttacaaag aaacaaattt tgagcagcaa     4800

tgacaattca accatatcta gattctccct accttatttc tccagccagt cacaccaggc     4860

agacgggtaa cctttaacag acctggtgtt ctcatggaat accgatgctc gtcccaggga     4920

gctgaccttt ctcactatgt ccttatagag ctgctcttac agagaacttt gtgctcagga     4980

ccaagggatg gtcaattaaa agttgcatgt aagcatcagg cttggatggg caagggaggg     5040

cttttataca tctttgaacg accaggtctt tccttgtctg cctgaaggca gagcttcgag     5100

aaacagcact tcccatgtgt ctggtcctct tggtctctca gccagacact taatcaatcc     5160

tggactctcc agtagtcctc agtcattgta gccatagcat ctgcaaaaaa agaaatgcta     5220

aaataatcat tagcgttttc aaaattagga aatcaaagta gctgggtcac tctcttacat     5280

gtgtatgagc cagttaattc tgctggacag atcatactta cgctgctgat tgactcttct     5340

gagcagtaac acatctcctg aattaattag gtaggtcccg tttgggtgct ttaagtggga     5400

tcagtcttag atgagtgcca gtatgtgatt gaatttcata cgcacaaatg ccatgattca     5460

agttctctct ccagtttttc ttatagatca acacacagta catgtggtca gttacttggt     5520

tgaatttctg cttagctgtg gtaagagaca gagaaaggga gtgaggtggg accaggggaa     5580

ttatcagaaa gacatgagtg aacctattgg ccaggtagct tccaagtatg ttctattgta     5640

ttgtctgttt tgattctgat agtttagaac tctttctgat agtttagaac tcttacccag     5700

tggttacatg actgatcaag gcaactccat ctggaaatta attgcttggg taaaatgtcc     5760

ctgagtttca acttgtcttt tatctctgga tattctctta tgagattatt atgcatgttt     5820

ctgtcacatg ggcattattt acacacttga taaatgaaag gtatttctct gtccgttcaa     5880

ggaaataaaa tgtaagttct tgttttatta aatgaatgaa gccttttggt taaaaaaaaa     5940

gtaatgtaat atgtttctgt tcaaacttga gctaatgaca tttaaggaat taaagacatt     6000

gatctagttc ttagtatgaa aagtgtacat gtagatatag ttatataatt gtgtatatac     6060

atatctacac acatggttgg ttttatattg ctttttcatc aatatttttg actgaaacct     6120

ttacaataaa ttttatttta attatgtaac cactaatatt ttgagagaag gaagcaaatg     6180

ttatatgtcc ttctgttaaa agaaaaaaaa ttcagtcctc cgccaaccgc ttcccacaca     6240

ctcatactct gcacatcttg gctacattaa aatggactga cagaattatt taaaaggcac     6300

tatgaaggta gaacactacc ttaatatttt atcctagtca gaagcctgat ttaacactga     6360

actttgaagg gaagcttagc tgtagctcat ggctttcaaa gattagaaga aacatttact     6420

ggttctatgg aaaatagtct tcttgctagg tagattggaa acaaagaaat tgcattggtg     6480

gtgttaaaat ctaacattta taacaaatcc tgttttattc tagatgaaat acttagacaa     6540

ttcttccagt ggaaaccagt gaactttttt aacagctttg ggaattcttt tgtatgataa     6600

tttttaaaat gaaatgtgta ctcttcaaac taattaaagc ttgaagtttt ccaggagtcg     6660

cattttaaaa gtgtttgtac acattttaac acttggatat tttctatttt ggttttgtat     6720

atttttatgt atacacaatg tacagacttt tttcttgtaa ataaaacatg ttttcatttg     6780

tctagaaaaa aaaaaaaaaa a                                               6801


<210>  472
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445             


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460                 


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480 


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495     


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510         


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525             


Ser 
    


<210>  473
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  473
ttccgccggg gcaggcgccg ggactccctc ctggccgccc acagcctgtg cgcattcctg       60

cattcctgcc gccgcccggg acccgagtgc cccggaggtg tccaggcgcg gtgccaggcg      120

ggtactgtgc aggttcattc tgccacccat ctgcattaag acacaaggtg ctgaccgcag      180

agacctgcca tgaaaccaca cttgaagcaa tggagacaac gaatgctttt cggaatattc      240

gcttgggggc tcctcttttt gctgattttc atctacttca ccgacagcaa ccccgctgag      300

cctgtaccca gctccctctc cttcctggag accaggaggc tcctgccggt gcaggggaag      360

cagcgggcca tcatgggcgc cgcacatgag ccctccccgc ctgggggcct ggacgcacgc      420

caggcgctgc cccgcgccca cccagccggt tcctttcatg cggggcctgg agacctgcag      480

aaatgggccc agtcccaaga tgggtttgaa cataaagagt ttttttcatc ccaggtgggg      540

agaaaatctc aaagtgcttt ctacccggag gatgacgact acttttttgc tgctggtcag      600

ccagggtggc acagccacac tcaggggaca ttgggattcc cttcccccgg ggagccaggc      660

ccacgggagg gggcttttcc ggctgcacag gtccagagga ggcgggtgaa gaagaggcac      720

cggaggcaga gaaggagcca cgtgttggag gagggcgacg acggcgacag gctgtactcc      780

tccatgtcca gggccttcct gtaccggctc tggaagggga acgtctcttc caaaatgctg      840

aacccgcgcc tgcagaaggc gatgaaggat tacctgaccg ccaacaagca cggggtgcgc      900

ttccgcggga agcgggaggc cgggctgagc agggcacagc tgctgtgcca gctgcggagc      960

cgcgcgcgcg tgcggacgct ggacggcacc gaggcgccct tttctgcgct gggctggcgg     1020

cgcctggtgc ccgccgtgcc cctgagccag ctgcaccccc gcggcctgcg cagctgcgct     1080

gtcgtcatgt ctgcaggcgc aatcctcaac tcttccttgg gcgaggaaat agattctcat     1140

gatgcggttt tgagatttaa ctctgctcct acacgtggtt atgagaaaga tgttgggaat     1200

aaaaccacca tacgcatcat taattcgcag attctgacca accccagcca tcacttcatt     1260

gacagttcac tgtataaaga cgtcattttg gtggcctggg accctgcccc atattccgca     1320

aatcttaacc tgtggtacaa aaaaccggat tacaacctgt tcactccata tattcagcat     1380

cgtcagagaa acccaaatca gccattttac attcttcatc ctaaatttat atggcagctc     1440

tgggatatta tccaggagaa cactaaagag aagattcaac caaacccacc atcttctggt     1500

ttcattggct catttgtaaa aattggccat atcagagctt gcagtgagcc gagatcacgc     1560

gactgcactc cagcctggac gacagagtga gactccatct caaaaaaaaa aaaaaaactg     1620

gccatataag aaacttaaca ttcatactgt ttaaag                               1656


<210>  474
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ser Phe Val Lys Ile Gly His Ile 
        435                 440                 445             


Arg Ala Cys Ser Glu Pro Arg Ser Arg Asp Cys Thr Pro Ala Trp Thr 
    450                 455                 460                 


Thr Glu 
465     


<210>  475
<211>  6871
<212>  DNA
<213>  Homo sapiens

<400>  475
ttccgccggg gcaggcgccg ggactccctc ctggccgccc acagcctgtg cgcattcctg       60

cattcctgcc gccgcccggg acccgagtgc cccggaggtg tccaggcgcg gtgccaggcg      120

ggtactgtgc aggttcattc tgccacccat ctgcattaag acacaaggtg ctgaccgcag      180

agacctgcca tgaaaccaca cttgaagcaa tggagacaac gaatgctttt cggaatattc      240

gcttgggggc tcctcttttt gctgattttc atctacttca ccgacagcaa ccccgctgag      300

cctgtaccca gctccctctc cttcctggag accaggaggc tcctgccggt gcaggggaag      360

cagcgggcca tcatgggcgc cgcacatgag ccctccccgc ctgggggcct ggacgcacgc      420

caggcgctgc cccgcgccca cccagccggt tcctttcatg cggggcctgg agacctgcag      480

aaatgggccc agtcccaaga tgggtttgaa cataaagagt ttttttcatc ccaggtgggg      540

agaaaatctc aaagtgcttt ctacccggag gatgacgact acttttttgc tgctggtcag      600

ccagggtggc acagccacac tcaggggaca ttgggattcc cttcccccgg ggagccaggc      660

ccacgggagg gggcttttcc ggctgcacag gtccagagga ggcgggtgaa gaagaggcac      720

cggaggcaga gaaggagcca cgtgttggag gagggcgacg acggcgacag gctgtactcc      780

tccatgtcca gggccttcct gtaccggctc tggaagggga acgtctcttc caaaatgctg      840

aacccgcgcc tgcagaaggc gatgaaggat tacctgaccg ccaacaagca cggggtgcgc      900

ttccgcggga agcgggaggc cgggctgagc agggcacagc tgctgtgcca gctgcggagc      960

cgcgcgcgcg tgcggacgct ggacggcacc gaggcgccct tttctgcgct gggctggcgg     1020

cgcctggtgc ccgccgtgcc cctgagccag ctgcaccccc gcggcctgcg cagctgcgct     1080

gtcgtcatgt ctgcaggcgc aatcctcaac tcttccttgg gcgaggaaat agattctcat     1140

gatgcggttt tgagatttaa ctctgctcct acacgtggtt atgagaaaga tgttgggaat     1200

aaaaccacca tacgcatcat taattcgcag attctgacca accccagcca tcacttcatt     1260

gacagttcac tgtataaaga cgtcattttg gtggcctggg accctgcccc atattccgca     1320

aatcttaacc tgtggtacaa aaaaccggat tacaacctgt tcactccata tattcagcat     1380

cgtcagagaa acccaaatca gccattttac attcttcatc ctaaatttat atggcagctc     1440

tgggatatta tccaggagaa cactaaagag aagattcaac caaacccacc atcttctggt     1500

ttcattggaa tcctcataat gatgtccatg tgcagagagg tgcacgtgta tgaatatatc     1560

ccatccgtgc ggcagacgga gctgtgccac taccacgagc tgtactacga cgcagcctgc     1620

accctcgggg cgtaccaccc actactctat gagaagctcc tggtgcagcg cctgaacatg     1680

ggcacgcagg gggatttgca tcgcaagggc aaggtggttc ttcccggctt ccaggcggtg     1740

cactgccctg caccaagtcc agtcattcca cactcttaaa aagggtttct tgggaatcaa     1800

tgtgcaataa ggtactactg ttgtactcaa agtcacaaaa gaatacttga agatagattt     1860

tagacagtgt agttttgagt ctttaaacag taatttagtg gtggtcatga taatccttct     1920

ctttctaagc cattgagtat gtattactgc tttgaacata gaaatggttt ttttaaaaaa     1980

ataaggctca agaaagatgc aaaaccaagg atagctagaa agaaaacaca tgtatgacca     2040

tgggtatgat acctccagaa atgttaacaa cttattcttc tgccatgagt acccctcatc     2100

agggttggtt tcaatgacag gttttggtga tgttcctgac catatgaagt ggtttatgtt     2160

tagaaacatt caaattgagg gacatcattt acagcatcga gtgtgtcagt tatacatgca     2220

ttcatcatta aatatcctag gttttatgac agacattgaa attatcactc agatgtgttt     2280

aacagcaaaa aattcccagc acatcctggc aaaggctttt atttccaacc gttgcattct     2340

tcatctctgc ctcccattgc ccactgaatg ctttgctttc tgtgcatcaa gacagagttc     2400

taaaaccaga aaacatccat cttgaaaggt ccaagaaaaa gccaaattcc atatagcacc     2460

acagaggagg ccctttgttt ccctgcagta tttcaaccag gaacattagt atcacatcca     2520

ccaggaggca catcactggc aagtaacata gaatcacagg gctgcaggtg cccctggaca     2580

ctccccggtt ctggcttttc tgccttgtac ctcctcacct gcagatctac cctgcagctt     2640

ttgcatagtc agtgacacac ttgacaattg gcacagctgt gctggggaag acgggagaca     2700

ccttgctcct tccaaactag aaggaaagat tttggagcca tcaccctgtg cttctaggga     2760

tgcacgcctg tctttattat acaggtttct tgcaggtttt tatcagccag tgggaactcc     2820

acagtgatga gcactgaatc ttcactaaat cttcctacag acatttagga atccagtcct     2880

tgcttttgca gatatgtttt atgtcagcag catgacaaag ccatataatt aaataattta     2940

tgtgaaagca ttgcttatta acaaggaaaa tatgtagatg cttcagaggg aaaggcagct     3000

agagggaaat tttcatccca atatgttagc tatattcagg gttgattttt tctttaatct     3060

caactgtcac tgatacattg aaaaattttt gctatgaata tagtgaaaca gaaacattct     3120

gtaatacctt aattaaacat gctattattt caatgtataa ccaaaacata tctccatggt     3180

acagttaaga cttgttgcaa tgacaatagc agcttaatta aatgcgttct cccttgcaaa     3240

atgtatgaat gtcaggagag tttagtggaa aagttttctt tgtttcagga ttggtttctt     3300

ctagactgtt ctcaggacta ctttcttgag caagaatggc ttacagagac tgaaggcttc     3360

tgtttggtta gtctattcag cagatatgga gctggaaaac aagacatctc ctatagcttg     3420

ctataatagt gaaggagaaa ttggaaagtt ttaatcacaa taatatccaa taaaagccca     3480

ttttgagagt tttgttatta agtcaatgag aagggatagg taactttgtc ctatatatta     3540

acttatgtct aaatagacat ggttaagcca tgttcctttc taatttcttt tcttttcttt     3600

tttttttttt tttttgagac agtctctcgc tctgtcgccc aggctagagt gcagtggtgc     3660

gatcttggtt cactgccagc tctgcctccc acgttcacac cattctcctg cctcagcctc     3720

ctgagtagct ggggactaca ggcacccgcc accacgccca gctaattttt tgtattttta     3780

gtagagacag ggtttcaccg tgttagccag ggtggtctcg atctcctgac cttgtgatct     3840

gcctgcctcg gcctcccaaa gtgatgggat tataggcgtg agccaccacc gcgcccggtc     3900

attcctttct aatttcttga aaaaactttg tcttgtcctt atgtttacat gtgtgtaata     3960

atttcagcaa ctctggaatg tgggtgaggt ggctgtggtg gatgaatatt actccctacc     4020

ctccttggat ctttctagat cttccagacc attaaatgcc cctgaagctc cttttatagt     4080

tttgcaagtg gatttacttg tagacatcct tactatccag cataatcccc cttggctgac     4140

atgagaactt ggttagagga gaatttattg gggtcagtgt aaatattcaa gttcaaaagc     4200

ctcagaaccc aacactttaa agatttttaa atggaatttt gtcgtagtca ttgtactttt     4260

aaaatagtac tttcagtttc attgaggtta caagaaagac tgaagagtac aaaggaaatt     4320

tagttacaat ttttgcattt attatggcct taaagactct tgggaatcag gctctgttca     4380

acagtcaata aatgtaatac acacattaat atagtactga ctgggcgttc ttctataaaa     4440

gtttaagttc tttggcttct aagaaaatgt tgggcagtta cagttaactt gatgactact     4500

tctagtatta gccaaatggg tcctaagtgg cagcattttg ccagacattg actaaatcct     4560

tacatgccac atttactgaa ttccaataaa catatagttc ttctgtggag tagttaacag     4620

taagtggcag ctcactgaat ttctcccagg ttctgtctct tccaaaatcc tccatcctct     4680

cttatgaagg gaagctgata aaaaaaaatc ctcttggtgc aagctgaagc tgttaaggat     4740

tccttttttc actctcagga ccaacagacg ttcttttgta tttcaagata atttcacctg     4800

ttgttgttgt tgttgttgtt gttgttgttg ttgttgttgt tgttacaaag aaacaaattt     4860

tgagcagcaa tgacaattca accatatcta gattctccct accttatttc tccagccagt     4920

cacaccaggc agacgggtaa cctttaacag acctggtgtt ctcatggaat accgatgctc     4980

gtcccaggga gctgaccttt ctcactatgt ccttatagag ctgctcttac agagaacttt     5040

gtgctcagga ccaagggatg gtcaattaaa agttgcatgt aagcatcagg cttggatggg     5100

caagggaggg cttttataca tctttgaacg accaggtctt tccttgtctg cctgaaggca     5160

gagcttcgag aaacagcact tcccatgtgt ctggtcctct tggtctctca gccagacact     5220

taatcaatcc tggactctcc agtagtcctc agtcattgta gccatagcat ctgcaaaaaa     5280

agaaatgcta aaataatcat tagcgttttc aaaattagga aatcaaagta gctgggtcac     5340

tctcttacat gtgtatgagc cagttaattc tgctggacag atcatactta cgctgctgat     5400

tgactcttct gagcagtaac acatctcctg aattaattag gtaggtcccg tttgggtgct     5460

ttaagtggga tcagtcttag atgagtgcca gtatgtgatt gaatttcata cgcacaaatg     5520

ccatgattca agttctctct ccagtttttc ttatagatca acacacagta catgtggtca     5580

gttacttggt tgaatttctg cttagctgtg gtaagagaca gagaaaggga gtgaggtggg     5640

accaggggaa ttatcagaaa gacatgagtg aacctattgg ccaggtagct tccaagtatg     5700

ttctattgta ttgtctgttt tgattctgat agtttagaac tctttctgat agtttagaac     5760

tcttacccag tggttacatg actgatcaag gcaactccat ctggaaatta attgcttggg     5820

taaaatgtcc ctgagtttca acttgtcttt tatctctgga tattctctta tgagattatt     5880

atgcatgttt ctgtcacatg ggcattattt acacacttga taaatgaaag gtatttctct     5940

gtccgttcaa ggaaataaaa tgtaagttct tgttttatta aatgaatgaa gccttttggt     6000

taaaaaaaaa gtaatgtaat atgtttctgt tcaaacttga gctaatgaca tttaaggaat     6060

taaagacatt gatctagttc ttagtatgaa aagtgtacat gtagatatag ttatataatt     6120

gtgtatatac atatctacac acatggttgg ttttatattg ctttttcatc aatatttttg     6180

actgaaacct ttacaataaa ttttatttta attatgtaac cactaatatt ttgagagaag     6240

gaagcaaatg ttatatgtcc ttctgttaaa agaaaaaaaa ttcagtcctc cgccaaccgc     6300

ttcccacaca ctcatactct gcacatcttg gctacattaa aatggactga cagaattatt     6360

taaaaggcac tatgaaggta gaacactacc ttaatatttt atcctagtca gaagcctgat     6420

ttaacactga actttgaagg gaagcttagc tgtagctcat ggctttcaaa gattagaaga     6480

aacatttact ggttctatgg aaaatagtct tcttgctagg tagattggaa acaaagaaat     6540

tgcattggtg gtgttaaaat ctaacattta taacaaatcc tgttttattc tagatgaaat     6600

acttagacaa ttcttccagt ggaaaccagt gaactttttt aacagctttg ggaattcttt     6660

tgtatgataa tttttaaaat gaaatgtgta ctcttcaaac taattaaagc ttgaagtttt     6720

ccaggagtcg cattttaaaa gtgtttgtac acattttaac acttggatat tttctatttt     6780

ggttttgtat atttttatgt atacacaatg tacagacttt tttcttgtaa ataaaacatg     6840

ttttcatttg tctagaaaaa aaaaaaaaaa a                                    6871


<210>  476
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445             


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460                 


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480 


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495     


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510         


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525             


Ser 
    


<210>  477
<211>  445
<212>  DNA
<213>  Homo sapiens

<400>  477
gcatgtgtct gctgctccct agtctgggcc atgagtgagg gtggaggcca agtctcatgc       60

atttttgcag cccccacaag actgtgcagg tggccggccc tcattgaatg cggggttaat      120

ttaactcagc ctctgtgtga gtggatgatt caggttgcca gagacagaac cctcagctta      180

gcatgggaag tagcttccct gttgaccctg agttcatctg aggttggctt ggaaggtgtg      240

ggcaccattt ggcccagttc ttacagctct gaagagagca gcaggaatgg ggctgagcag      300

ggaagacaac tttccattga aggccccttt cagggccaga actgtccctc ccaccctgca      360

gctgccctgc ctctgcccat gaggggtgag agtcaggcga cctcatgcca agtgtagaaa      420

ggggcagacg ggagccccag gttat                                            445


<210>  478
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ser Glu Gly Gly Gly Gln Val Ser Cys Ile Phe Ala Ala Pro Thr 
1               5                   10                  15      


Arg Leu Cys Arg Trp Pro Ala Leu Ile Glu Cys Gly Val Asn Leu Thr 
            20                  25                  30          


Gln Pro Leu Cys Glu Trp Met Ile Gln Val Ala Arg Asp Arg Thr Leu 
        35                  40                  45              


Ser Leu Ala Trp Glu Val Ala Ser Leu Leu Thr Leu Ser Ser Ser Glu 
    50                  55                  60                  


Val Gly Leu Glu Gly Val Gly Thr Ile Trp Pro Ser Ser Tyr Ser Ser 
65                  70                  75                  80  


Glu Glu Ser Ser Arg Asn Gly Ala Glu Gln Gly Arg Gln Leu Ser Ile 
                85                  90                  95      


Glu Gly Pro Phe Gln Gly Gln Asn Cys Pro Ser His Pro Ala Ala Ala 
            100                 105                 110         


Leu Pro Leu Pro Met Arg Gly Glu Ser Gln Ala Thr Ser Cys Gln Val 
        115                 120                 125             


<210>  479
<211>  5896
<212>  DNA
<213>  Homo sapiens

<400>  479
cgactccatt ttcctcggtg ggggcttagc gcactggagg agcggcgggc ttcagacagt       60

tatcttcagg cagagtgaga agctgcagca atgtctgatt ttgtggaaag cgaggctgag      120

gagtcagagg aagaatacaa tgatgaaggc gaggtggtac cccgagtcac caagaaattt      180

gtggaagagg aggatgatga tgaggaggag gaggaggaga acctagatga tcaggatgag      240

caaggcaact tgaaaggctt tatcaatgac gatgatgatg aagatgaagg ggaggaggat      300

gagggcagtg actctggtga ttcagaagat gatgttggcc acaagaagag aaaacgcacc      360

tcttttgatg accgcctgga ggatgatgat tttgacctca ttgaggagaa tttgggtgtc      420

aaagtcaaaa gaggacaaaa gtaccggcgt gtcaaaaaaa tgtcagatga cgaggacgat      480

gacgaggagg aatatggcaa ggaggaacat gaaaaagaag ctattgcgga agaaatcttc      540

caggatgggg aaggggaaga agggcaggag gccatggagg cccccatggc tcctccagag      600

gaggaggaag aagatgatga ggagtcagat attgacgact tcattgtgga tgatgatgga      660

cagcctctga aaaaacctaa gtggcggaaa aagcttcctg gatacacaga cgcggccctg      720

caagaagccc aggaaatctt cggtgtggac tttgactatg atgaatttga gaaatacaat      780

gagtatgatg aagaactgga ggaagagtat gagtatgagg atgatgaggc tgagggtgaa      840

atccgagtgc gccccaagaa gaccaccaag aagcgtgtga gccgtaggag catctttgaa      900

atgtatgagc ccagtgagct agaaagcagc cacctcacag atcaggacaa tgaaatccga      960

gccactgacc tgcctgagag gttccagctc cgctccatcc cagtcaaggg ggctgaagat     1020

gatgaactag aagaagaagc tgactggatc tacaggaatg cttttgccac accaaccatt     1080

tctctccagg aaagctgtga ttacctagac cgagggcagc cagccagcag cttcagtcgg     1140

aaagggccca gcacaattca gaagatcaaa gaggccctgg gcttcatgcg aaatcagcat     1200

tttgaggtgc cttttattgc cttctatcga aaggagtatg tggagcctga gttgcacatc     1260

aatgacctat ggagagtctg gcagtgggat gaaaagtgga cccagctgcg gatccgtaaa     1320

gagaacctaa cacggctgtt tgagaagatg caggcttatc agtatgaaca gatctctgct     1380

gaccctgaca aacctcttgc tgatggcatc cgggctctgg acaccactga catggagagg     1440

ctcaaggatg tccaatcaat ggatgagctg aaagatgtct acaaccattt tcttctttat     1500

tatggccgag acatccctaa gatgcagaac gccgccaaag ctagccgcaa gaagctgaag     1560

cgtgtcaggg aagagggaga tgaagaaggt gaaggtgacg aggcagaaga tgaggagcag     1620

agggggcctg agctcaagca agcctctcgc cgagacatgt acaccatctg ccagagtgct     1680

gggctagatg gcctggccaa aaagtttggg cttactcccg agcagtttgg ggagaacctg     1740

cgggatagct accagcggca cgagacagag cagtttcccg cggagccctt ggagctggcc     1800

aaggattacg tttgcagcca gttccctact ccagaagctg tgctagaagg cgcccgctac     1860

atggtagccc tgcagattgc ccgtgagccc cttgtccggc aggtgctgag gcaaaccttc     1920

caagagagag ccaagttaaa tataaccccc accaagaaag gtagaaagga tgtggatgag     1980

gcccactatg cctattcctt caagtattta aagaacaagc ctgttaagga actgagagat     2040

gaccagtttc tcaagatatg cctggctgaa gacgaagggc tcctcaccac tgacatcagc     2100

atagatttga agggagtgga aggctatggc aacgaccaga catattttga ggagataaaa     2160

cagttttact accgagatga gttcagccac caggtgcagg agtggaaccg gcagcgcacc     2220

atggccatcg aacgggcttt acagcagttc ctctatgtgc agatggccaa agaactcaag     2280

aacaagctgc tggctgaagc caaggaatat gtcataaagg cctgtagtcg aaagctctac     2340

aattggttga gagtggcacc ctaccgacca gatcagcagg tggaagaaga tgacgacttt     2400

atggacgaga accaagggaa gggcattcga gtcctcggca ttgctttctc ctctgccaga     2460

gatcaccctg tgttctgcgc cctggtcaat ggtgaaggag aagtgacaga cttccttcga     2520

ctgccccatt ttaccaaacg gcgaactgca tggagagagg aagagcggga aaagaaggct     2580

caagacattg aaacgctaaa gaaatttctc ctgaataaga agcctcatgt agtgacagtt     2640

gcaggagaga acagggacgc ccagatgttg attgaagatg tgaagcgcat tgtacatgag     2700

ctggaccagg gccagcagct gtcatctatt ggggtagagc tggttgacaa cgagttggcc     2760

attctctata tgaacagcaa gaagtcagag gcagagttcc gggattatcc tccagtgctg     2820

agacaggccg tctccctggc ccggcgcatc caggaccctc tgattgaatt tgcccaggtg     2880

tgcagttccg atgaagacat cctgtgtctc aagtttcacc ccttgcagga gcatgtggtg     2940

aaagaggagc tgctcaacgc cttgtactgt gaatttatca accgagtcaa tgaggtcggg     3000

gtcgatgtca accgtgccat tgcccaccct tacagccagg ccttgatcca gtatgtttgt     3060

ggcctgggac ctcggaaagg gacccacctc ctgaagatcc tgaagcagaa caacacccgg     3120

ctcgagagcc ggacccagct ggtcaccatg tgccacatgg gtcccaaagt cttcatgaat     3180

tgtgctggct tcctcaagat cgacacggcc tccctggggg acagcactga ctcatatatt     3240

gaagtccttg atggttcccg tgtccaccct gagacttatg agtgggctag gaagatggca     3300

gtggatgccc tggaatacga tgaatcagcc gaggatgcca atcctgcagg agcccttgaa     3360

gaaatcttgg aaaacccaga gcgactgaaa gacctggacc ttgatgcctt tgcagaagag     3420

ctggagaggc agggctatgg tgacaaacac atcacactct atgacatccg ggcagagctg     3480

agctgtcgat ataaggacct ccggacagcc taccgctctc ccaacacaga ggagatcttc     3540

aatatgttaa ccaaagaaac accagagacc ttctacattg gaaagctcat catctgcaat     3600

gtcactggca ttgcccacag gcgtccccag ggtgagagct atgaccaggc gatccgcaat     3660

gatgagacag ggctgtggca gtgccccttc tgtcagcagg acaatttccc tgaactaagc     3720

gaggtgtgga accactttga cagcggttcg tgcccaggcc aggccatcgg tgtcaaaaca     3780

cggctagaca atggtgtcac cggcttcatc cccaccaaat tcctcagtga caaagtggta     3840

aagcggccag aagaacgagt gaaggtggga atgactgttc actgccgcat catgaagatt     3900

gacattgaga agttcagtgc agacctgacc tgccgcacct cagacctcat ggacaggaac     3960

aatgagtgga agctgcccaa agacacctac tatgactttg atgctgaagc tgcagaccac     4020

aagcaggagg aggacatgaa gcggaagcag cagcggacca catacatcaa gagagtgatc     4080

gcacacccat ccttccataa tatcaatttc aagcaagcag aaaagatgat ggagaccatg     4140

gaccagggtg atgtgattat ccgaccaagc agcaagggcg agaaccacct gacagtgacc     4200

tggaaagtca gtgatggcat ctaccagcat gtggatgtgc gggaggaggg caaggaaaat     4260

gccttcagcc tgggagccac tctgtggatc aacagtgagg aattcgaaga tttggatgag     4320

attgttgctc gctatgtcca gcccatggca tcctttgccc gggaccttct gaatcacaag     4380

tattatcagg actgcagcgg tggggaccgc aagaaattag aggagctgct catcaaaact     4440

aagaaggaga agcccacctt catcccttat ttcatctgtg cctgcaagga actgcccggc     4500

aagttcctac tgggatacca gccccggggt aaacccagga tagaatatgt aacggtgact     4560

ccagagggat tccggtaccg gggccagatc ttcccaaccg tgaatggact gtttagatgg     4620

tttaaggatc actaccagga tcctgtacca ggcatcaccc ctagcagcag cagcaggacc     4680

cggacacctg cctctatcaa tgctacccca gccaacatca accttgcaga tctgacacgg     4740

gctgtgaatg ccctgcctca gaacatgact tcacagatgt tcagtgccat tgctgcggtg     4800

acaggccaag gacagaaccc taatgccacc ccagcccagt gggcctccag ccagtacggc     4860

tatggcggca gtggaggcgg cagcagtgct taccacgtat tcccaacgcc agcccagcag     4920

ccagtggcca caccactaat gacccctagc tactcctaca cgaccccaag ccagcccatc     4980

accacccctc agtaccacca gctccaggcc agcaccaccc cacagtcggc ccaggcccag     5040

ccccagccct cttccagctc ccggcaacgg cagcagcagc caaagtccaa cagccatgca     5100

gccatcgact ggggaaaaat ggcggagcag tggctgcagg aaaaggaggc agaacggcgg     5160

aaacagaagc agcggctgac acctcggccc tcccccagcc ccatgatcga aagcaccccc     5220

atgtccattg ctggcgatgc caccccactc ctggacgaga tggatcggta gggggcctgc     5280

tcctcggact ctggttacct ctgaggctgg gaaaggcctg gctgcccact gcctccctcc     5340

ctgcccctcc ttttatgtcc ataaagtggc gtgaagtgag acgttctctt tggtggtcaa     5400

cccggatggg tgacaggctg gatggccttg tgaacttgag ctcagtgtat gctaggcaac     5460

aattctcccg ctccagaccc tcaccgacca cctgtcctgg gaccaggctg ggaggggagt     5520

gtggcaggga ggaggaagag gaaggtgaga atgagtagaa cagttttgta ttctactccc     5580

tacaagccat tttgaacttc tgccctcacc ggactctggg ctgtgactgg ggcaccaaac     5640

tcagcacatg agtctcccct agctctcgtg gggagaggga tgctatttat tcagtttggg     5700

gcaggaggga gaggagggaa agtatttctg accctgatgc caacagccgg gtggctgtcc     5760

aagcaggatt gcaggggaca cagggaagca ctgcccagcc cctgcctggc tgccctttcc     5820

cccctgctgc tgccaccgct tcctgcctgt catttgaata aacagtgttt ctattgaaaa     5880

aaaaaaaaaa aaaaaa                                                     5896


<210>  480
<211>  1726
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Ser Asp Phe Val Glu Ser Glu Ala Glu Glu Ser Glu Glu Glu Tyr 
1               5                   10                  15      


Asn Asp Glu Gly Glu Val Val Pro Arg Val Thr Lys Lys Phe Val Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Glu Glu Glu Glu Glu Glu Asn Leu Asp Asp Gln 
        35                  40                  45              


Asp Glu Gln Gly Asn Leu Lys Gly Phe Ile Asn Asp Asp Asp Asp Glu 
    50                  55                  60                  


Asp Glu Gly Glu Glu Asp Glu Gly Ser Asp Ser Gly Asp Ser Glu Asp 
65                  70                  75                  80  


Asp Val Gly His Lys Lys Arg Lys Arg Thr Ser Phe Asp Asp Arg Leu 
                85                  90                  95      


Glu Asp Asp Asp Phe Asp Leu Ile Glu Glu Asn Leu Gly Val Lys Val 
            100                 105                 110         


Lys Arg Gly Gln Lys Tyr Arg Arg Val Lys Lys Met Ser Asp Asp Glu 
        115                 120                 125             


Asp Asp Asp Glu Glu Glu Tyr Gly Lys Glu Glu His Glu Lys Glu Ala 
    130                 135                 140                 


Ile Ala Glu Glu Ile Phe Gln Asp Gly Glu Gly Glu Glu Gly Gln Glu 
145                 150                 155                 160 


Ala Met Glu Ala Pro Met Ala Pro Pro Glu Glu Glu Glu Glu Asp Asp 
                165                 170                 175     


Glu Glu Ser Asp Ile Asp Asp Phe Ile Val Asp Asp Asp Gly Gln Pro 
            180                 185                 190         


Leu Lys Lys Pro Lys Trp Arg Lys Lys Leu Pro Gly Tyr Thr Asp Ala 
        195                 200                 205             


Ala Leu Gln Glu Ala Gln Glu Ile Phe Gly Val Asp Phe Asp Tyr Asp 
    210                 215                 220                 


Glu Phe Glu Lys Tyr Asn Glu Tyr Asp Glu Glu Leu Glu Glu Glu Tyr 
225                 230                 235                 240 


Glu Tyr Glu Asp Asp Glu Ala Glu Gly Glu Ile Arg Val Arg Pro Lys 
                245                 250                 255     


Lys Thr Thr Lys Lys Arg Val Ser Arg Arg Ser Ile Phe Glu Met Tyr 
            260                 265                 270         


Glu Pro Ser Glu Leu Glu Ser Ser His Leu Thr Asp Gln Asp Asn Glu 
        275                 280                 285             


Ile Arg Ala Thr Asp Leu Pro Glu Arg Phe Gln Leu Arg Ser Ile Pro 
    290                 295                 300                 


Val Lys Gly Ala Glu Asp Asp Glu Leu Glu Glu Glu Ala Asp Trp Ile 
305                 310                 315                 320 


Tyr Arg Asn Ala Phe Ala Thr Pro Thr Ile Ser Leu Gln Glu Ser Cys 
                325                 330                 335     


Asp Tyr Leu Asp Arg Gly Gln Pro Ala Ser Ser Phe Ser Arg Lys Gly 
            340                 345                 350         


Pro Ser Thr Ile Gln Lys Ile Lys Glu Ala Leu Gly Phe Met Arg Asn 
        355                 360                 365             


Gln His Phe Glu Val Pro Phe Ile Ala Phe Tyr Arg Lys Glu Tyr Val 
    370                 375                 380                 


Glu Pro Glu Leu His Ile Asn Asp Leu Trp Arg Val Trp Gln Trp Asp 
385                 390                 395                 400 


Glu Lys Trp Thr Gln Leu Arg Ile Arg Lys Glu Asn Leu Thr Arg Leu 
                405                 410                 415     


Phe Glu Lys Met Gln Ala Tyr Gln Tyr Glu Gln Ile Ser Ala Asp Pro 
            420                 425                 430         


Asp Lys Pro Leu Ala Asp Gly Ile Arg Ala Leu Asp Thr Thr Asp Met 
        435                 440                 445             


Glu Arg Leu Lys Asp Val Gln Ser Met Asp Glu Leu Lys Asp Val Tyr 
    450                 455                 460                 


Asn His Phe Leu Leu Tyr Tyr Gly Arg Asp Ile Pro Lys Met Gln Asn 
465                 470                 475                 480 


Ala Ala Lys Ala Ser Arg Lys Lys Leu Lys Arg Val Arg Glu Glu Gly 
                485                 490                 495     


Asp Glu Glu Gly Glu Gly Asp Glu Ala Glu Asp Glu Glu Gln Arg Gly 
            500                 505                 510         


Pro Glu Leu Lys Gln Ala Ser Arg Arg Asp Met Tyr Thr Ile Cys Gln 
        515                 520                 525             


Ser Ala Gly Leu Asp Gly Leu Ala Lys Lys Phe Gly Leu Thr Pro Glu 
    530                 535                 540                 


Gln Phe Gly Glu Asn Leu Arg Asp Ser Tyr Gln Arg His Glu Thr Glu 
545                 550                 555                 560 


Gln Phe Pro Ala Glu Pro Leu Glu Leu Ala Lys Asp Tyr Val Cys Ser 
                565                 570                 575     


Gln Phe Pro Thr Pro Glu Ala Val Leu Glu Gly Ala Arg Tyr Met Val 
            580                 585                 590         


Ala Leu Gln Ile Ala Arg Glu Pro Leu Val Arg Gln Val Leu Arg Gln 
        595                 600                 605             


Thr Phe Gln Glu Arg Ala Lys Leu Asn Ile Thr Pro Thr Lys Lys Gly 
    610                 615                 620                 


Arg Lys Asp Val Asp Glu Ala His Tyr Ala Tyr Ser Phe Lys Tyr Leu 
625                 630                 635                 640 


Lys Asn Lys Pro Val Lys Glu Leu Arg Asp Asp Gln Phe Leu Lys Ile 
                645                 650                 655     


Cys Leu Ala Glu Asp Glu Gly Leu Leu Thr Thr Asp Ile Ser Ile Asp 
            660                 665                 670         


Leu Lys Gly Val Glu Gly Tyr Gly Asn Asp Gln Thr Tyr Phe Glu Glu 
        675                 680                 685             


Ile Lys Gln Phe Tyr Tyr Arg Asp Glu Phe Ser His Gln Val Gln Glu 
    690                 695                 700                 


Trp Asn Arg Gln Arg Thr Met Ala Ile Glu Arg Ala Leu Gln Gln Phe 
705                 710                 715                 720 


Leu Tyr Val Gln Met Ala Lys Glu Leu Lys Asn Lys Leu Leu Ala Glu 
                725                 730                 735     


Ala Lys Glu Tyr Val Ile Lys Ala Cys Ser Arg Lys Leu Tyr Asn Trp 
            740                 745                 750         


Leu Arg Val Ala Pro Tyr Arg Pro Asp Gln Gln Val Glu Glu Asp Asp 
        755                 760                 765             


Asp Phe Met Asp Glu Asn Gln Gly Lys Gly Ile Arg Val Leu Gly Ile 
    770                 775                 780                 


Ala Phe Ser Ser Ala Arg Asp His Pro Val Phe Cys Ala Leu Val Asn 
785                 790                 795                 800 


Gly Glu Gly Glu Val Thr Asp Phe Leu Arg Leu Pro His Phe Thr Lys 
                805                 810                 815     


Arg Arg Thr Ala Trp Arg Glu Glu Glu Arg Glu Lys Lys Ala Gln Asp 
            820                 825                 830         


Ile Glu Thr Leu Lys Lys Phe Leu Leu Asn Lys Lys Pro His Val Val 
        835                 840                 845             


Thr Val Ala Gly Glu Asn Arg Asp Ala Gln Met Leu Ile Glu Asp Val 
    850                 855                 860                 


Lys Arg Ile Val His Glu Leu Asp Gln Gly Gln Gln Leu Ser Ser Ile 
865                 870                 875                 880 


Gly Val Glu Leu Val Asp Asn Glu Leu Ala Ile Leu Tyr Met Asn Ser 
                885                 890                 895     


Lys Lys Ser Glu Ala Glu Phe Arg Asp Tyr Pro Pro Val Leu Arg Gln 
            900                 905                 910         


Ala Val Ser Leu Ala Arg Arg Ile Gln Asp Pro Leu Ile Glu Phe Ala 
        915                 920                 925             


Gln Val Cys Ser Ser Asp Glu Asp Ile Leu Cys Leu Lys Phe His Pro 
    930                 935                 940                 


Leu Gln Glu His Val Val Lys Glu Glu Leu Leu Asn Ala Leu Tyr Cys 
945                 950                 955                 960 


Glu Phe Ile Asn Arg Val Asn Glu Val Gly Val Asp Val Asn Arg Ala 
                965                 970                 975     


Ile Ala His Pro Tyr Ser Gln Ala Leu Ile Gln Tyr Val Cys Gly Leu 
            980                 985                 990         


Gly Pro Arg Lys Gly Thr His Leu  Leu Lys Ile Leu Lys  Gln Asn Asn 
        995                 1000                 1005             


Thr Arg  Leu Glu Ser Arg Thr  Gln Leu Val Thr Met  Cys His Met 
    1010                 1015                 1020             


Gly Pro  Lys Val Phe Met Asn  Cys Ala Gly Phe Leu  Lys Ile Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Gly Asp Ser  Thr Asp Ser Tyr Ile  Glu Val Leu 
    1040                 1045                 1050             


Asp Gly  Ser Arg Val His Pro  Glu Thr Tyr Glu Trp  Ala Arg Lys 
    1055                 1060                 1065             


Met Ala  Val Asp Ala Leu Glu  Tyr Asp Glu Ser Ala  Glu Asp Ala 
    1070                 1075                 1080             


Asn Pro  Ala Gly Ala Leu Glu  Glu Ile Leu Glu Asn  Pro Glu Arg 
    1085                 1090                 1095             


Leu Lys  Asp Leu Asp Leu Asp  Ala Phe Ala Glu Glu  Leu Glu Arg 
    1100                 1105                 1110             


Gln Gly  Tyr Gly Asp Lys His  Ile Thr Leu Tyr Asp  Ile Arg Ala 
    1115                 1120                 1125             


Glu Leu  Ser Cys Arg Tyr Lys  Asp Leu Arg Thr Ala  Tyr Arg Ser 
    1130                 1135                 1140             


Pro Asn  Thr Glu Glu Ile Phe  Asn Met Leu Thr Lys  Glu Thr Pro 
    1145                 1150                 1155             


Glu Thr  Phe Tyr Ile Gly Lys  Leu Ile Ile Cys Asn  Val Thr Gly 
    1160                 1165                 1170             


Ile Ala  His Arg Arg Pro Gln  Gly Glu Ser Tyr Asp  Gln Ala Ile 
    1175                 1180                 1185             


Arg Asn  Asp Glu Thr Gly Leu  Trp Gln Cys Pro Phe  Cys Gln Gln 
    1190                 1195                 1200             


Asp Asn  Phe Pro Glu Leu Ser  Glu Val Trp Asn His  Phe Asp Ser 
    1205                 1210                 1215             


Gly Ser  Cys Pro Gly Gln Ala  Ile Gly Val Lys Thr  Arg Leu Asp 
    1220                 1225                 1230             


Asn Gly  Val Thr Gly Phe Ile  Pro Thr Lys Phe Leu  Ser Asp Lys 
    1235                 1240                 1245             


Val Val  Lys Arg Pro Glu Glu  Arg Val Lys Val Gly  Met Thr Val 
    1250                 1255                 1260             


His Cys  Arg Ile Met Lys Ile  Asp Ile Glu Lys Phe  Ser Ala Asp 
    1265                 1270                 1275             


Leu Thr  Cys Arg Thr Ser Asp  Leu Met Asp Arg Asn  Asn Glu Trp 
    1280                 1285                 1290             


Lys Leu  Pro Lys Asp Thr Tyr  Tyr Asp Phe Asp Ala  Glu Ala Ala 
    1295                 1300                 1305             


Asp His  Lys Gln Glu Glu Asp  Met Lys Arg Lys Gln  Gln Arg Thr 
    1310                 1315                 1320             


Thr Tyr  Ile Lys Arg Val Ile  Ala His Pro Ser Phe  His Asn Ile 
    1325                 1330                 1335             


Asn Phe  Lys Gln Ala Glu Lys  Met Met Glu Thr Met  Asp Gln Gly 
    1340                 1345                 1350             


Asp Val  Ile Ile Arg Pro Ser  Ser Lys Gly Glu Asn  His Leu Thr 
    1355                 1360                 1365             


Val Thr  Trp Lys Val Ser Asp  Gly Ile Tyr Gln His  Val Asp Val 
    1370                 1375                 1380             


Arg Glu  Glu Gly Lys Glu Asn  Ala Phe Ser Leu Gly  Ala Thr Leu 
    1385                 1390                 1395             


Trp Ile  Asn Ser Glu Glu Phe  Glu Asp Leu Asp Glu  Ile Val Ala 
    1400                 1405                 1410             


Arg Tyr  Val Gln Pro Met Ala  Ser Phe Ala Arg Asp  Leu Leu Asn 
    1415                 1420                 1425             


His Lys  Tyr Tyr Gln Asp Cys  Ser Gly Gly Asp Arg  Lys Lys Leu 
    1430                 1435                 1440             


Glu Glu  Leu Leu Ile Lys Thr  Lys Lys Glu Lys Pro  Thr Phe Ile 
    1445                 1450                 1455             


Pro Tyr  Phe Ile Cys Ala Cys  Lys Glu Leu Pro Gly  Lys Phe Leu 
    1460                 1465                 1470             


Leu Gly  Tyr Gln Pro Arg Gly  Lys Pro Arg Ile Glu  Tyr Val Thr 
    1475                 1480                 1485             


Val Thr  Pro Glu Gly Phe Arg  Tyr Arg Gly Gln Ile  Phe Pro Thr 
    1490                 1495                 1500             


Val Asn  Gly Leu Phe Arg Trp  Phe Lys Asp His Tyr  Gln Asp Pro 
    1505                 1510                 1515             


Val Pro  Gly Ile Thr Pro Ser  Ser Ser Ser Arg Thr  Arg Thr Pro 
    1520                 1525                 1530             


Ala Ser  Ile Asn Ala Thr Pro  Ala Asn Ile Asn Leu  Ala Asp Leu 
    1535                 1540                 1545             


Thr Arg  Ala Val Asn Ala Leu  Pro Gln Asn Met Thr  Ser Gln Met 
    1550                 1555                 1560             


Phe Ser  Ala Ile Ala Ala Val  Thr Gly Gln Gly Gln  Asn Pro Asn 
    1565                 1570                 1575             


Ala Thr  Pro Ala Gln Trp Ala  Ser Ser Gln Tyr Gly  Tyr Gly Gly 
    1580                 1585                 1590             


Ser Gly  Gly Gly Ser Ser Ala  Tyr His Val Phe Pro  Thr Pro Ala 
    1595                 1600                 1605             


Gln Gln  Pro Val Ala Thr Pro  Leu Met Thr Pro Ser  Tyr Ser Tyr 
    1610                 1615                 1620             


Thr Thr  Pro Ser Gln Pro Ile  Thr Thr Pro Gln Tyr  His Gln Leu 
    1625                 1630                 1635             


Gln Ala  Ser Thr Thr Pro Gln  Ser Ala Gln Ala Gln  Pro Gln Pro 
    1640                 1645                 1650             


Ser Ser  Ser Ser Arg Gln Arg  Gln Gln Gln Pro Lys  Ser Asn Ser 
    1655                 1660                 1665             


His Ala  Ala Ile Asp Trp Gly  Lys Met Ala Glu Gln  Trp Leu Gln 
    1670                 1675                 1680             


Glu Lys  Glu Ala Glu Arg Arg  Lys Gln Lys Gln Arg  Leu Thr Pro 
    1685                 1690                 1695             


Arg Pro  Ser Pro Ser Pro Met  Ile Glu Ser Thr Pro  Met Ser Ile 
    1700                 1705                 1710             


Ala Gly  Asp Ala Thr Pro Leu  Leu Asp Glu Met Asp  Arg 
    1715                 1720                 1725     


<210>  481
<211>  7709
<212>  DNA
<213>  Homo sapiens

<400>  481
aagggagctc agtaagtcac ttctgggcga ctgttgtttt atttccggtc tatgggaccc       60

ggctgcgatt tgctgctgcg gacagcagct accatcactg ctgccgccat catgtcagac      120

acggacagcg acgaagattc cgctggaggc ggcccatttt ctttagcggg tttccttttc      180

ggcaacatca atggagccgg gcagctggag ggggaaagcg tcttggatga tgaatgtaag      240

aagcacttgg caggcttggg ggctttgggg ctgggcagcc tgatcactga actcacggca      300

aatgaagaat tgaccgggac tgacggtgcc ttggtaaatg atgaagggtg ggttaggagt      360

acagaagatg ctgtggacta ttcagacatc aatgaggtgg cagaagatga aagccgaaga      420

taccagcaga cgatggggag cttgcagccc ctttgccact cagattatga tgaagatgac      480

tatgatgctg attgtgaaga cattgattgc aagttgatgc ctcctccacc tccacccccg      540

ggaccaatga agaaggataa ggaccaggat tctattactg gtgtgtctga aaatggagaa      600

ggcatcatct tgccctccat cattgcccct tcctctttgg cctcagagaa agtggacttc      660

agtagttcct ctgactcaga atctgagatg ggacctcagg aagcaacaca ggcagaatct      720

gaagatggaa agctgaccct tccattggct gggattatgc agcatgatgc caccaagctg      780

ttgccaagtg tcacagaact ttttccagaa tttcgacctg gaaaggtgtt acgttttcta      840

cgtctttttg gaccagggaa gaatgtccca tctgtttggc ggagtgctcg gagaaagagg      900

aagaagaagc accgtgagct gatacaggaa gagcagatcc aggaggtgga gtgctcagta      960

gaatcagaag tcagccagaa gtctttgtgg aactacgact acgctccacc accacctcca     1020

gagcagtgtc tctctgatga tgaaatcacg atgatggctc ctgtggagtc caaattttcc     1080

caatcaactg gagatataga taaagtgaca gataccaaac caagagtggc tgagtggcgt     1140

tatgggcctg cccgactgtg gtatgatatg ctgggtgtcc ctgaagatgg cagtgggttt     1200

gactatggct tcaaactgag aaagacagaa catgaacctg tgataaaatc tagaatgata     1260

gaggaattta ggaaacttga ggaaaacaat ggcactgatc ttctggctga tgaaaacttc     1320

ctgatggtga cacagctgca ttgggaggat gatatcatct gggatgggga ggatgtcaaa     1380

cacaaaggga caaaacctca gcgtgcaagc ctggcaggct ggcttccttc tagcatgact     1440

aggaatgcga tggcttacaa tgttcagcaa ggttttgcag ccactcttga tgatgacaaa     1500

ccttggtact ccatttttcc cattgacaat gaggatctgg tatatggacg ctgggaggac     1560

aatatcattt gggatgctca ggccatgccc cggctgttgg aacctcctgt tttgacactt     1620

gatcccaatg atgagaacct cattttggaa attcctgatg agaaggaaga ggccacctct     1680

aactccccct ccaaggagag taagaaggaa tcatctctga agaagagtcg aattctctta     1740

gggaaaacag gagtcatcaa ggaggaacca cagcagaaca tgtctcagcc agaagtgaaa     1800

gatccatgga atctctccaa tgatgagtat tattatccca agcaacaggg tcttcgaggc     1860

acctttggag ggaatattat ccagcattca attcctgctg tggaattacg gcagcccttc     1920

tttcccaccc acatggggcc catcaaactc cggcagttcc atcgcccacc tctgaaaaag     1980

tactcatttg gtgcactttc tcagccaggt ccccactcag tccaaccttt gctaaagcac     2040

atcaaaaaaa aggccaagat gagagaacaa gagaggcaag cttcaggtgg tggagagatg     2100

ttttttatgc gcacacctca ggacctcaca ggcaaagatg gtgatcttat tcttgcagaa     2160

tatagtgagg aaaatggacc cttaatgatg caggttggca tggcaaccaa gataaagaac     2220

tattataaac ggaaacctgg aaaagatcct ggagcaccag attgtaaata tggggaaact     2280

gtttactgcc atacatctcc tttcctgggt tctctccatc ctggccaatt gctgcaagca     2340

tttgagaaca acctttttcg tgctccaatt tatcttcata agatgccaga aactgatttc     2400

ttgatcattc ggacaagaca gggttactat attcgggaat tagtggatat ttttgtggtt     2460

ggccagcagt gtcccttgtt tgaagttcct gggcctaact ccaaaagggc caatacgcat     2520

attcgagact ttctacaggt ttttatttac cgccttttct ggaaaagtaa agatcggcca     2580

cggaggatac gaatggaaga tataaaaaaa gcctttcctt cccattcaga aagcagcatc     2640

cggaagaggc taaagctctg cgctgacttc aaacgcacag ggatggactc aaactggtgg     2700

gtgcttaagt ctgattttcg tttaccaacg gaagaagaga tcagagctat ggtgtcacca     2760

gagcagtgct gtgcttatta tagcatgata gctgcagagc aacgactgaa ggatgctggc     2820

tatggtgaga aatccttttt tgctccagaa gaagaaaatg aggaagattt ccagatgaag     2880

attgatgatg aagttcgcac tgccccttgg aacaccacaa gggccttcat tgctgccatg     2940

aagggcaagt gtctgctaga ggtgactggg gtggcagatc ccacggggtg tggtgaagga     3000

ttctcctatg tgaagattcc aaacaaacca acacagcaga aggatgataa agaaccgcag     3060

ccagtgaaga agacagtgac aggaacagat gcagaccttc gtcgcctttc cctgaaaaat     3120

gccaagcaac ttctacgtaa atttggtgtg cctgaggaag agattaaaaa gttgtcccgc     3180

tgggaagtga ttgatgtggt gcgcacaatg tcaacagaac aggctcgttc tggagagggg     3240

cccatgagta aatttgcccg tggatcaagg ttttctgtgg ctgagcatca agagcgttac     3300

aaagaggaat gtcagcgcat ctttgaccta cagaacaagg ttctgtcatc aactgaagtc     3360

ttatcaactg acacagacag cagctcagct gaagatagtg actttgaaga aatgggaaag     3420

aacattgaga acatgttgca gaacaagaaa accagctctc agctttcacg tgaacgggag     3480

gaacaggagc ggaaggaact acagcgaatg ctactggcag caggctcagc agcatccgga     3540

aacaatcaca gagatgatga cacagcttcc gtgactagcc ttaactcttc tgccactgga     3600

cgctgtctca agatttatcg cacgtttcga gatgaagagg ggaaagagta tgttcgctgt     3660

gagacagtcc gaaaaccagc tgtcattgat gcctatgtgc gcatacggac tacaaaagat     3720

gaggaattca ttcgaaaatt tgcccttttt gatgaacaac atcgggaaga gatgcgaaaa     3780

gaacggcgga ggattcaaga gcaactgagg cggcttaaga ggaaccagga aaaggagaag     3840

cttaagggtc ctcctgagaa gaagcccaag aaaatgaagg agcgtcctga cctaaaactg     3900

aaatgtgggg catgtggtgc cattggacac atgaggacta acaaattctg ccccctctat     3960

tatcaaacaa atgcgccacc ttccaaccct gttgccatga cagaagaaca ggaggaggag     4020

ttggaaaaga cagtcattca taatgataat gaagaactta tcaaggttga agggaccaaa     4080

attgtcttgg ggaaacagct aattgagagt gcggatgagg ttcgcagaaa atctctggtt     4140

ctcaagtttc ctaaacagca gcttcctcca aagaagaaac ggcgagttgg aaccactgtt     4200

cactgtgact atttgaatag acctcataag tccatccacc ggcgccgcac agaccctatg     4260

gtgacgctgt cgtccatctt ggagtctatc atcaatgaca tgagagatct tccaaataca     4320

taccctttcc acactccagt caatgcaaag gttgtaaagg actactacaa aatcatcact     4380

cggccaatgg acctacaaac actccgcgaa aacgtgcgta aacgcctcta cccatctcgg     4440

gaagagttca gagagcatct ggagctaatt gtgaaaaata gtgcaaccta caatgggcca     4500

aaacactcat tgactcagat ctctcaatcc atgctggatc tctgtgatga aaaactcaaa     4560

gagaaagaag acaaattagc tcgcttagag aaagctatca accccttgct ggatgatgat     4620

gaccaagtgg cgttttcttt cattctggac aacattgtca cccagaaaat gatggcagtt     4680

ccagattctt ggccatttca tcacccagtt aataagaaat ttgttccaga ttattacaaa     4740

gtgattgtca atccaatgga tttagagacc atacgtaaga acatctccaa gcacaagtat     4800

cagagtcggg agagctttct ggatgatgta aaccttattc tggccaacag tgttaagtat     4860

aatggacctg agagtcagta tactaagact gcccaggaga ttgtgaacgt ctgttaccag     4920

acattgactg agtatgatga acatttgact caacttgaga aggatatttg tactgctaaa     4980

gaagcagctt tggaggaagc agaattagaa agcctggacc caatgacccc agggccctac     5040

acgcctcagc ctcctgattt gtatgatacc aacacatccc tcagtatgtc tcgagatgcc     5100

tctgtatttc aagatgagag caatatgtct gtcttggata ttcccagtgc cactccagaa     5160

aagcaggtaa cacaggaagg tgaagatgga gatggtgatc ttgcagatga agaggaagga     5220

actgtacaac agcctcaagc cagtgtcctg tatgaggatt tgcttatgtc tgaaggagaa     5280

gatgatgagg aagatgctgg gagtgatgaa gaaggagaca atcctttctc tgctatccag     5340

ctgagtgaaa gtggaagtga ctctgatgtg ggatctggtg gaataagacc caaacaaccc     5400

cgcatgcttc aggagaacac aaggatggac atggaaaatg aagaaagcat gatgtcctat     5460

gagggagacg gtggggaggc ttcccatggt ttggaggata gcaacatcag ttatgggagc     5520

tatgaggagc ctgatcccaa gtcgaacacc caagacacaa gcttcagcag catcggtggg     5580

tatgaggtat cagaggagga agaagatgag gaggaggaag agcagcgctc tgggccgagc     5640

gtactaagcc aggtccacct gtcagaggac gaggaggaca gtgaggattt ccactccatt     5700

gctggggaca gtgacttgga ctctgatgaa tgaggcttcc tttgggcctc cttggtcagc     5760

cttccctgtt ctccagccta ggtggttcac ctttccccaa tttgttcata tttgtacagt     5820

atctgatcct gaaatcatga aattaactaa caccttagcc tttttaaaag tagtaagtaa     5880

atgataataa atcacctctc ctaatcttcc tggggcaatg tcaccctttg atttaaaaca     5940

aagcaacccc ctttccccta ccactacgga aaagagcaag ctcatttttc cgtgtcctcc     6000

tttatttaac tccatttatt gcttttggta taatttttcc ctggggaagg aggggaaatt     6060

atgaaagaac tagtaacttt atgtcctctt gatgtattag gaaatttccg gccaggcgtg     6120

gtggctcaca cctgtaatct cagcactctg ggaggccgag gcgggcagat cacctgaggt     6180

cagaagttcg agaccagctt ggccaacatg gcgaaaccgc atctctacta aaaatacaaa     6240

aattagccag gtgtggtggc gtatgcctgt taatcctagc tactcgggag gctgaggcag     6300

gagaattact tgaacccggg aggcagaggt tgcagtgagt ggaggtcacg ccactgcact     6360

ccagcctggg cgaaagagtg agattcagtc tcaaaaaaaa aaaaatttcc aagcatggta     6420

tcatctcact tttctaattt acaggctgga gcagatgaga gccctcctgc tgggacagag     6480

aattgggttc tagtggactc tgtgctacac ttaaacctgt gagacaaacc gcccattatt     6540

ttattattta attatgcaat gcctagttcc taaatggatt ggaggcaaat taccgtaaat     6600

tttgaaacag cctatatgtc agaaatgata atgttgccac ctaaatgttt tctgtccccc     6660

ccaccctccc caggggaaat ggtaggaaaa tggtaagttt cttagggcaa agactgtgtc     6720

ttctgtttct tttcatgctt aggatatggt tctgtgcata gtaggtactc agtaaatgtt     6780

cctagaatca taaaatcctc aacagatatg ttactgagca tctgcttttc atgataagca     6840

ctctatcaga tccttgggat gcaaaggtaa ataagacaaa tcccttttac ccaaagagct     6900

caccatcaag ttgggggagg gaaagtggaa ttcaaaacat gttaataaat catcatagta     6960

ctgtgagata agtgcaatta agaagctagt tataaagtat aggggaaata gaggagtaat     7020

catgtctgaa aagtcaggaa agtcttccta gaggtaattt ttaagctgat tgttttagaa     7080

ttagtagaag cttgccagat ggaaaagtcc aggcaaagtg taacatgaat gggaaaggcc     7140

acagtctaga aatggcagag tgtgttccta gtttgtttgt ttgtttgttt gtacctgcct     7200

tgttccagga aggatttaat gtggtttata ttccagtcct ttaatgctgg aagggctgag     7260

atgagactga aagatgggca ggaagtatat catcacaagc tttgtgtttg atgttaatgt     7320

gtatgatttt tatattatgg gaaataagct cttagaggag tgatataatc aggtttgtgt     7380

tttagaaatc tgtgtaatga atgaatgaag aaagaaattg aagaatcatg taacatatgt     7440

gatcgcattt ttgtaaaaga accatgtgtg tttatatgtg tttatatata tacttgtgta     7500

tgcaaaggta aaagtctgaa aggatatatg ctaactgttc acaatgataa ccccccagga     7560

atgggattgg aggggagggg gcttctgtgt ttgttatgta tgctgggtgg gatattgtgc     7620

ttttatttct atattgtttg aattttttta cagtatgtat tatttttgta ataaaaattt     7680

taaaaaattc caaaaaaaaa aaaaaaaaa                                       7709


<210>  482
<211>  1893
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Gly Pro Gly Cys Asp Leu Leu Leu Arg Thr Ala Ala Thr Ile Thr 
1               5                   10                  15      


Ala Ala Ala Ile Met Ser Asp Thr Asp Ser Asp Glu Asp Ser Ala Gly 
            20                  25                  30          


Gly Gly Pro Phe Ser Leu Ala Gly Phe Leu Phe Gly Asn Ile Asn Gly 
        35                  40                  45              


Ala Gly Gln Leu Glu Gly Glu Ser Val Leu Asp Asp Glu Cys Lys Lys 
    50                  55                  60                  


His Leu Ala Gly Leu Gly Ala Leu Gly Leu Gly Ser Leu Ile Thr Glu 
65                  70                  75                  80  


Leu Thr Ala Asn Glu Glu Leu Thr Gly Thr Asp Gly Ala Leu Val Asn 
                85                  90                  95      


Asp Glu Gly Trp Val Arg Ser Thr Glu Asp Ala Val Asp Tyr Ser Asp 
            100                 105                 110         


Ile Asn Glu Val Ala Glu Asp Glu Ser Arg Arg Tyr Gln Gln Thr Met 
        115                 120                 125             


Gly Ser Leu Gln Pro Leu Cys His Ser Asp Tyr Asp Glu Asp Asp Tyr 
    130                 135                 140                 


Asp Ala Asp Cys Glu Asp Ile Asp Cys Lys Leu Met Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Pro Gly Pro Met Lys Lys Asp Lys Asp Gln Asp Ser Ile Thr 
                165                 170                 175     


Gly Val Ser Glu Asn Gly Glu Gly Ile Ile Leu Pro Ser Ile Ile Ala 
            180                 185                 190         


Pro Ser Ser Leu Ala Ser Glu Lys Val Asp Phe Ser Ser Ser Ser Asp 
        195                 200                 205             


Ser Glu Ser Glu Met Gly Pro Gln Glu Ala Thr Gln Ala Glu Ser Glu 
    210                 215                 220                 


Asp Gly Lys Leu Thr Leu Pro Leu Ala Gly Ile Met Gln His Asp Ala 
225                 230                 235                 240 


Thr Lys Leu Leu Pro Ser Val Thr Glu Leu Phe Pro Glu Phe Arg Pro 
                245                 250                 255     


Gly Lys Val Leu Arg Phe Leu Arg Leu Phe Gly Pro Gly Lys Asn Val 
            260                 265                 270         


Pro Ser Val Trp Arg Ser Ala Arg Arg Lys Arg Lys Lys Lys His Arg 
        275                 280                 285             


Glu Leu Ile Gln Glu Glu Gln Ile Gln Glu Val Glu Cys Ser Val Glu 
    290                 295                 300                 


Ser Glu Val Ser Gln Lys Ser Leu Trp Asn Tyr Asp Tyr Ala Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Glu Gln Cys Leu Ser Asp Asp Glu Ile Thr Met Met Ala 
                325                 330                 335     


Pro Val Glu Ser Lys Phe Ser Gln Ser Thr Gly Asp Ile Asp Lys Val 
            340                 345                 350         


Thr Asp Thr Lys Pro Arg Val Ala Glu Trp Arg Tyr Gly Pro Ala Arg 
        355                 360                 365             


Leu Trp Tyr Asp Met Leu Gly Val Pro Glu Asp Gly Ser Gly Phe Asp 
    370                 375                 380                 


Tyr Gly Phe Lys Leu Arg Lys Thr Glu His Glu Pro Val Ile Lys Ser 
385                 390                 395                 400 


Arg Met Ile Glu Glu Phe Arg Lys Leu Glu Glu Asn Asn Gly Thr Asp 
                405                 410                 415     


Leu Leu Ala Asp Glu Asn Phe Leu Met Val Thr Gln Leu His Trp Glu 
            420                 425                 430         


Asp Asp Ile Ile Trp Asp Gly Glu Asp Val Lys His Lys Gly Thr Lys 
        435                 440                 445             


Pro Gln Arg Ala Ser Leu Ala Gly Trp Leu Pro Ser Ser Met Thr Arg 
    450                 455                 460                 


Asn Ala Met Ala Tyr Asn Val Gln Gln Gly Phe Ala Ala Thr Leu Asp 
465                 470                 475                 480 


Asp Asp Lys Pro Trp Tyr Ser Ile Phe Pro Ile Asp Asn Glu Asp Leu 
                485                 490                 495     


Val Tyr Gly Arg Trp Glu Asp Asn Ile Ile Trp Asp Ala Gln Ala Met 
            500                 505                 510         


Pro Arg Leu Leu Glu Pro Pro Val Leu Thr Leu Asp Pro Asn Asp Glu 
        515                 520                 525             


Asn Leu Ile Leu Glu Ile Pro Asp Glu Lys Glu Glu Ala Thr Ser Asn 
    530                 535                 540                 


Ser Pro Ser Lys Glu Ser Lys Lys Glu Ser Ser Leu Lys Lys Ser Arg 
545                 550                 555                 560 


Ile Leu Leu Gly Lys Thr Gly Val Ile Lys Glu Glu Pro Gln Gln Asn 
                565                 570                 575     


Met Ser Gln Pro Glu Val Lys Asp Pro Trp Asn Leu Ser Asn Asp Glu 
            580                 585                 590         


Tyr Tyr Tyr Pro Lys Gln Gln Gly Leu Arg Gly Thr Phe Gly Gly Asn 
        595                 600                 605             


Ile Ile Gln His Ser Ile Pro Ala Val Glu Leu Arg Gln Pro Phe Phe 
    610                 615                 620                 


Pro Thr His Met Gly Pro Ile Lys Leu Arg Gln Phe His Arg Pro Pro 
625                 630                 635                 640 


Leu Lys Lys Tyr Ser Phe Gly Ala Leu Ser Gln Pro Gly Pro His Ser 
                645                 650                 655     


Val Gln Pro Leu Leu Lys His Ile Lys Lys Lys Ala Lys Met Arg Glu 
            660                 665                 670         


Gln Glu Arg Gln Ala Ser Gly Gly Gly Glu Met Phe Phe Met Arg Thr 
        675                 680                 685             


Pro Gln Asp Leu Thr Gly Lys Asp Gly Asp Leu Ile Leu Ala Glu Tyr 
    690                 695                 700                 


Ser Glu Glu Asn Gly Pro Leu Met Met Gln Val Gly Met Ala Thr Lys 
705                 710                 715                 720 


Ile Lys Asn Tyr Tyr Lys Arg Lys Pro Gly Lys Asp Pro Gly Ala Pro 
                725                 730                 735     


Asp Cys Lys Tyr Gly Glu Thr Val Tyr Cys His Thr Ser Pro Phe Leu 
            740                 745                 750         


Gly Ser Leu His Pro Gly Gln Leu Leu Gln Ala Phe Glu Asn Asn Leu 
        755                 760                 765             


Phe Arg Ala Pro Ile Tyr Leu His Lys Met Pro Glu Thr Asp Phe Leu 
    770                 775                 780                 


Ile Ile Arg Thr Arg Gln Gly Tyr Tyr Ile Arg Glu Leu Val Asp Ile 
785                 790                 795                 800 


Phe Val Val Gly Gln Gln Cys Pro Leu Phe Glu Val Pro Gly Pro Asn 
                805                 810                 815     


Ser Lys Arg Ala Asn Thr His Ile Arg Asp Phe Leu Gln Val Phe Ile 
            820                 825                 830         


Tyr Arg Leu Phe Trp Lys Ser Lys Asp Arg Pro Arg Arg Ile Arg Met 
        835                 840                 845             


Glu Asp Ile Lys Lys Ala Phe Pro Ser His Ser Glu Ser Ser Ile Arg 
    850                 855                 860                 


Lys Arg Leu Lys Leu Cys Ala Asp Phe Lys Arg Thr Gly Met Asp Ser 
865                 870                 875                 880 


Asn Trp Trp Val Leu Lys Ser Asp Phe Arg Leu Pro Thr Glu Glu Glu 
                885                 890                 895     


Ile Arg Ala Met Val Ser Pro Glu Gln Cys Cys Ala Tyr Tyr Ser Met 
            900                 905                 910         


Ile Ala Ala Glu Gln Arg Leu Lys Asp Ala Gly Tyr Gly Glu Lys Ser 
        915                 920                 925             


Phe Phe Ala Pro Glu Glu Glu Asn Glu Glu Asp Phe Gln Met Lys Ile 
    930                 935                 940                 


Asp Asp Glu Val Arg Thr Ala Pro Trp Asn Thr Thr Arg Ala Phe Ile 
945                 950                 955                 960 


Ala Ala Met Lys Gly Lys Cys Leu Leu Glu Val Thr Gly Val Ala Asp 
                965                 970                 975     


Pro Thr Gly Cys Gly Glu Gly Phe Ser Tyr Val Lys Ile Pro Asn Lys 
            980                 985                 990         


Pro Thr Gln Gln Lys Asp Asp Lys  Glu Pro Gln Pro Val  Lys Lys Thr 
        995                 1000                 1005             


Val Thr  Gly Thr Asp Ala Asp  Leu Arg Arg Leu Ser  Leu Lys Asn 
    1010                 1015                 1020             


Ala Lys  Gln Leu Leu Arg Lys  Phe Gly Val Pro Glu  Glu Glu Ile 
    1025                 1030                 1035             


Lys Lys  Leu Ser Arg Trp Glu  Val Ile Asp Val Val  Arg Thr Met 
    1040                 1045                 1050             


Ser Thr  Glu Gln Ala Arg Ser  Gly Glu Gly Pro Met  Ser Lys Phe 
    1055                 1060                 1065             


Ala Arg  Gly Ser Arg Phe Ser  Val Ala Glu His Gln  Glu Arg Tyr 
    1070                 1075                 1080             


Lys Glu  Glu Cys Gln Arg Ile  Phe Asp Leu Gln Asn  Lys Val Leu 
    1085                 1090                 1095             


Ser Ser  Thr Glu Val Leu Ser  Thr Asp Thr Asp Ser  Ser Ser Ala 
    1100                 1105                 1110             


Glu Asp  Ser Asp Phe Glu Glu  Met Gly Lys Asn Ile  Glu Asn Met 
    1115                 1120                 1125             


Leu Gln  Asn Lys Lys Thr Ser  Ser Gln Leu Ser Arg  Glu Arg Glu 
    1130                 1135                 1140             


Glu Gln  Glu Arg Lys Glu Leu  Gln Arg Met Leu Leu  Ala Ala Gly 
    1145                 1150                 1155             


Ser Ala  Ala Ser Gly Asn Asn  His Arg Asp Asp Asp  Thr Ala Ser 
    1160                 1165                 1170             


Val Thr  Ser Leu Asn Ser Ser  Ala Thr Gly Arg Cys  Leu Lys Ile 
    1175                 1180                 1185             


Tyr Arg  Thr Phe Arg Asp Glu  Glu Gly Lys Glu Tyr  Val Arg Cys 
    1190                 1195                 1200             


Glu Thr  Val Arg Lys Pro Ala  Val Ile Asp Ala Tyr  Val Arg Ile 
    1205                 1210                 1215             


Arg Thr  Thr Lys Asp Glu Glu  Phe Ile Arg Lys Phe  Ala Leu Phe 
    1220                 1225                 1230             


Asp Glu  Gln His Arg Glu Glu  Met Arg Lys Glu Arg  Arg Arg Ile 
    1235                 1240                 1245             


Gln Glu  Gln Leu Arg Arg Leu  Lys Arg Asn Gln Glu  Lys Glu Lys 
    1250                 1255                 1260             


Leu Lys  Gly Pro Pro Glu Lys  Lys Pro Lys Lys Met  Lys Glu Arg 
    1265                 1270                 1275             


Pro Asp  Leu Lys Leu Lys Cys  Gly Ala Cys Gly Ala  Ile Gly His 
    1280                 1285                 1290             


Met Arg  Thr Asn Lys Phe Cys  Pro Leu Tyr Tyr Gln  Thr Asn Ala 
    1295                 1300                 1305             


Pro Pro  Ser Asn Pro Val Ala  Met Thr Glu Glu Gln  Glu Glu Glu 
    1310                 1315                 1320             


Leu Glu  Lys Thr Val Ile His  Asn Asp Asn Glu Glu  Leu Ile Lys 
    1325                 1330                 1335             


Val Glu  Gly Thr Lys Ile Val  Leu Gly Lys Gln Leu  Ile Glu Ser 
    1340                 1345                 1350             


Ala Asp  Glu Val Arg Arg Lys  Ser Leu Val Leu Lys  Phe Pro Lys 
    1355                 1360                 1365             


Gln Gln  Leu Pro Pro Lys Lys  Lys Arg Arg Val Gly  Thr Thr Val 
    1370                 1375                 1380             


His Cys  Asp Tyr Leu Asn Arg  Pro His Lys Ser Ile  His Arg Arg 
    1385                 1390                 1395             


Arg Thr  Asp Pro Met Val Thr  Leu Ser Ser Ile Leu  Glu Ser Ile 
    1400                 1405                 1410             


Ile Asn  Asp Met Arg Asp Leu  Pro Asn Thr Tyr Pro  Phe His Thr 
    1415                 1420                 1425             


Pro Val  Asn Ala Lys Val Val  Lys Asp Tyr Tyr Lys  Ile Ile Thr 
    1430                 1435                 1440             


Arg Pro  Met Asp Leu Gln Thr  Leu Arg Glu Asn Val  Arg Lys Arg 
    1445                 1450                 1455             


Leu Tyr  Pro Ser Arg Glu Glu  Phe Arg Glu His Leu  Glu Leu Ile 
    1460                 1465                 1470             


Val Lys  Asn Ser Ala Thr Tyr  Asn Gly Pro Lys His  Ser Leu Thr 
    1475                 1480                 1485             


Gln Ile  Ser Gln Ser Met Leu  Asp Leu Cys Asp Glu  Lys Leu Lys 
    1490                 1495                 1500             


Glu Lys  Glu Asp Lys Leu Ala  Arg Leu Glu Lys Ala  Ile Asn Pro 
    1505                 1510                 1515             


Leu Leu  Asp Asp Asp Asp Gln  Val Ala Phe Ser Phe  Ile Leu Asp 
    1520                 1525                 1530             


Asn Ile  Val Thr Gln Lys Met  Met Ala Val Pro Asp  Ser Trp Pro 
    1535                 1540                 1545             


Phe His  His Pro Val Asn Lys  Lys Phe Val Pro Asp  Tyr Tyr Lys 
    1550                 1555                 1560             


Val Ile  Val Asn Pro Met Asp  Leu Glu Thr Ile Arg  Lys Asn Ile 
    1565                 1570                 1575             


Ser Lys  His Lys Tyr Gln Ser  Arg Glu Ser Phe Leu  Asp Asp Val 
    1580                 1585                 1590             


Asn Leu  Ile Leu Ala Asn Ser  Val Lys Tyr Asn Gly  Pro Glu Ser 
    1595                 1600                 1605             


Gln Tyr  Thr Lys Thr Ala Gln  Glu Ile Val Asn Val  Cys Tyr Gln 
    1610                 1615                 1620             


Thr Leu  Thr Glu Tyr Asp Glu  His Leu Thr Gln Leu  Glu Lys Asp 
    1625                 1630                 1635             


Ile Cys  Thr Ala Lys Glu Ala  Ala Leu Glu Glu Ala  Glu Leu Glu 
    1640                 1645                 1650             


Ser Leu  Asp Pro Met Thr Pro  Gly Pro Tyr Thr Pro  Gln Pro Pro 
    1655                 1660                 1665             


Asp Leu  Tyr Asp Thr Asn Thr  Ser Leu Ser Met Ser  Arg Asp Ala 
    1670                 1675                 1680             


Ser Val  Phe Gln Asp Glu Ser  Asn Met Ser Val Leu  Asp Ile Pro 
    1685                 1690                 1695             


Ser Ala  Thr Pro Glu Lys Gln  Val Thr Gln Glu Gly  Glu Asp Gly 
    1700                 1705                 1710             


Asp Gly  Asp Leu Ala Asp Glu  Glu Glu Gly Thr Val  Gln Gln Pro 
    1715                 1720                 1725             


Gln Ala  Ser Val Leu Tyr Glu  Asp Leu Leu Met Ser  Glu Gly Glu 
    1730                 1735                 1740             


Asp Asp  Glu Glu Asp Ala Gly  Ser Asp Glu Glu Gly  Asp Asn Pro 
    1745                 1750                 1755             


Phe Ser  Ala Ile Gln Leu Ser  Glu Ser Gly Ser Asp  Ser Asp Val 
    1760                 1765                 1770             


Gly Ser  Gly Gly Ile Arg Pro  Lys Gln Pro Arg Met  Leu Gln Glu 
    1775                 1780                 1785             


Asn Thr  Arg Met Asp Met Glu  Asn Glu Glu Ser Met  Met Ser Tyr 
    1790                 1795                 1800             


Glu Gly  Asp Gly Gly Glu Ala  Ser His Gly Leu Glu  Asp Ser Asn 
    1805                 1810                 1815             


Ile Ser  Tyr Gly Ser Tyr Glu  Glu Pro Asp Pro Lys  Ser Asn Thr 
    1820                 1825                 1830             


Gln Asp  Thr Ser Phe Ser Ser  Ile Gly Gly Tyr Glu  Val Ser Glu 
    1835                 1840                 1845             


Glu Glu  Glu Asp Glu Glu Glu  Glu Glu Gln Arg Ser  Gly Pro Ser 
    1850                 1855                 1860             


Val Leu  Ser Gln Val His Leu  Ser Glu Asp Glu Glu  Asp Ser Glu 
    1865                 1870                 1875             


Asp Phe  His Ser Ile Ala Gly  Asp Ser Asp Leu Asp  Ser Asp Glu 
    1880                 1885                 1890             


<210>  483
<211>  7646
<212>  DNA
<213>  Homo sapiens

<400>  483
aagggagctc agtaagtcac ttctgggcga ctgttgtttt atttccggtc tatgggaccc       60

ggctgcgatt tgctgctgcg gacagcagct accatcactg ctgccgccat catgtcagac      120

acggacagcg acgaagattc cgctggaggc ggcccatttt ctttagcggg tttccttttc      180

ggcaacatca atggagccgg gcagctggag ggggaaagcg tcttggatga tgaatgtaag      240

aagcacttgg caggcttggg ggctttgggg ctgggcagcc tgatcactga actcacggca      300

aatgaagaat tgaccgggac tgacggtgcc ttggtaaatg atgaagggtg ggttaggagt      360

acagaagatg ctgtggacta ttcagacatc aatgaggtgg cagaagatga aagccgaaga      420

taccagcaga cgatggggag cttgcagccc ctttgccact cagattatga tgaagatgac      480

tatgatgctg attgtgaaga cattgattgc aagttgatgc ctcctccacc tccacccccg      540

ggaccaatga agaaggataa ggaccaggat tctattactg gtgagaaagt ggacttcagt      600

agttcctctg actcagaatc tgagatggga cctcaggaag caacacaggc agaatctgaa      660

gatggaaagc tgacccttcc attggctggg attatgcagc atgatgccac caagctgttg      720

ccaagtgtca cagaactttt tccagaattt cgacctggaa aggtgttacg ttttctacgt      780

ctttttggac cagggaagaa tgtcccatct gtttggcgga gtgctcggag aaagaggaag      840

aagaagcacc gtgagctgat acaggaagag cagatccagg aggtggagtg ctcagtagaa      900

tcagaagtca gccagaagtc tttgtggaac tacgactacg ctccaccacc acctccagag      960

cagtgtctct ctgatgatga aatcacgatg atggctcctg tggagtccaa attttcccaa     1020

tcaactggag atatagataa agtgacagat accaaaccaa gagtggctga gtggcgttat     1080

gggcctgccc gactgtggta tgatatgctg ggtgtccctg aagatggcag tgggtttgac     1140

tatggcttca aactgagaaa gacagaacat gaacctgtga taaaatctag aatgatagag     1200

gaatttagga aacttgagga aaacaatggc actgatcttc tggctgatga aaacttcctg     1260

atggtgacac agctgcattg ggaggatgat atcatctggg atggggagga tgtcaaacac     1320

aaagggacaa aacctcagcg tgcaagcctg gcaggctggc ttccttctag catgactagg     1380

aatgcgatgg cttacaatgt tcagcaaggt tttgcagcca ctcttgatga tgacaaacct     1440

tggtactcca tttttcccat tgacaatgag gatctggtat atggacgctg ggaggacaat     1500

atcatttggg atgctcaggc catgccccgg ctgttggaac ctcctgtttt gacacttgat     1560

cccaatgatg agaacctcat tttggaaatt cctgatgaga aggaagaggc cacctctaac     1620

tccccctcca aggagagtaa gaaggaatca tctctgaaga agagtcgaat tctcttaggg     1680

aaaacaggag tcatcaagga ggaaccacag cagaacatgt ctcagccaga agtgaaagat     1740

ccatggaatc tctccaatga tgagtattat tatcccaagc aacagggtct tcgaggcacc     1800

tttggaggga atattatcca gcattcaatt cctgctgtgg aattacggca gcccttcttt     1860

cccacccaca tggggcccat caaactccgg cagttccatc gcccacctct gaaaaagtac     1920

tcatttggtg cactttctca gccaggtccc cactcagtcc aacctttgct aaagcacatc     1980

aaaaaaaagg ccaagatgag agaacaagag aggcaagctt caggtggtgg agagatgttt     2040

tttatgcgca cacctcagga cctcacaggc aaagatggtg atcttattct tgcagaatat     2100

agtgaggaaa atggaccctt aatgatgcag gttggcatgg caaccaagat aaagaactat     2160

tataaacgga aacctggaaa agatcctgga gcaccagatt gtaaatatgg ggaaactgtt     2220

tactgccata catctccttt cctgggttct ctccatcctg gccaattgct gcaagcattt     2280

gagaacaacc tttttcgtgc tccaatttat cttcataaga tgccagaaac tgatttcttg     2340

atcattcgga caagacaggg ttactatatt cgggaattag tggatatttt tgtggttggc     2400

cagcagtgtc ccttgtttga agttcctggg cctaactcca aaagggccaa tacgcatatt     2460

cgagactttc tacaggtttt tatttaccgc cttttctgga aaagtaaaga tcggccacgg     2520

aggatacgaa tggaagatat aaaaaaagcc tttccttccc attcagaaag cagcatccgg     2580

aagaggctaa agctctgcgc tgacttcaaa cgcacaggga tggactcaaa ctggtgggtg     2640

cttaagtctg attttcgttt accaacggaa gaagagatca gagctatggt gtcaccagag     2700

cagtgctgtg cttattatag catgatagct gcagagcaac gactgaagga tgctggctat     2760

ggtgagaaat ccttttttgc tccagaagaa gaaaatgagg aagatttcca gatgaagatt     2820

gatgatgaag ttcgcactgc cccttggaac accacaaggg ccttcattgc tgccatgaag     2880

ggcaagtgtc tgctagaggt gactggggtg gcagatccca cggggtgtgg tgaaggattc     2940

tcctatgtga agattccaaa caaaccaaca cagcagaagg atgataaaga accgcagcca     3000

gtgaagaaga cagtgacagg aacagatgca gaccttcgtc gcctttccct gaaaaatgcc     3060

aagcaacttc tacgtaaatt tggtgtgcct gaggaagaga ttaaaaagtt gtcccgctgg     3120

gaagtgattg atgtggtgcg cacaatgtca acagaacagg ctcgttctgg agaggggccc     3180

atgagtaaat ttgcccgtgg atcaaggttt tctgtggctg agcatcaaga gcgttacaaa     3240

gaggaatgtc agcgcatctt tgacctacag aacaaggttc tgtcatcaac tgaagtctta     3300

tcaactgaca cagacagcag ctcagctgaa gatagtgact ttgaagaaat gggaaagaac     3360

attgagaaca tgttgcagaa caagaaaacc agctctcagc tttcacgtga acgggaggaa     3420

caggagcgga aggaactaca gcgaatgcta ctggcagcag gctcagcagc atccggaaac     3480

aatcacagag atgatgacac agcttccgtg actagcctta actcttctgc cactggacgc     3540

tgtctcaaga tttatcgcac gtttcgagat gaagagggga aagagtatgt tcgctgtgag     3600

acagtccgaa aaccagctgt cattgatgcc tatgtgcgca tacggactac aaaagatgag     3660

gaattcattc gaaaatttgc cctttttgat gaacaacatc gggaagagat gcgaaaagaa     3720

cggcggagga ttcaagagca actgaggcgg cttaagagga accaggaaaa ggagaagctt     3780

aagggtcctc ctgagaagaa gcccaagaaa atgaaggagc gtcctgacct aaaactgaaa     3840

tgtggggcat gtggtgccat tggacacatg aggactaaca aattctgccc cctctattat     3900

caaacaaatg cgccaccttc caaccctgtt gccatgacag aagaacagga ggaggagttg     3960

gaaaagacag tcattcataa tgataatgaa gaacttatca aggttgaagg gaccaaaatt     4020

gtcttgggga aacagctaat tgagagtgcg gatgaggttc gcagaaaatc tctggttctc     4080

aagtttccta aacagcagct tcctccaaag aagaaacggc gagttggaac cactgttcac     4140

tgtgactatt tgaatagacc tcataagtcc atccaccggc gccgcacaga ccctatggtg     4200

acgctgtcgt ccatcttgga gtctatcatc aatgacatga gagatcttcc aaatacatac     4260

cctttccaca ctccagtcaa tgcaaaggtt gtaaaggact actacaaaat catcactcgg     4320

ccaatggacc tacaaacact ccgcgaaaac gtgcgtaaac gcctctaccc atctcgggaa     4380

gagttcagag agcatctgga gctaattgtg aaaaatagtg caacctacaa tgggccaaaa     4440

cactcattga ctcagatctc tcaatccatg ctggatctct gtgatgaaaa actcaaagag     4500

aaagaagaca aattagctcg cttagagaaa gctatcaacc ccttgctgga tgatgatgac     4560

caagtggcgt tttctttcat tctggacaac attgtcaccc agaaaatgat ggcagttcca     4620

gattcttggc catttcatca cccagttaat aagaaatttg ttccagatta ttacaaagtg     4680

attgtcaatc caatggattt agagaccata cgtaagaaca tctccaagca caagtatcag     4740

agtcgggaga gctttctgga tgatgtaaac cttattctgg ccaacagtgt taagtataat     4800

ggacctgaga gtcagtatac taagactgcc caggagattg tgaacgtctg ttaccagaca     4860

ttgactgagt atgatgaaca tttgactcaa cttgagaagg atatttgtac tgctaaagaa     4920

gcagctttgg aggaagcaga attagaaagc ctggacccaa tgaccccagg gccctacacg     4980

cctcagcctc ctgatttgta tgataccaac acatccctca gtatgtctcg agatgcctct     5040

gtatttcaag atgagagcaa tatgtctgtc ttggatattc ccagtgccac tccagaaaag     5100

caggtaacac aggaaggtga agatggagat ggtgatcttg cagatgaaga ggaaggaact     5160

gtacaacagc ctcaagccag tgtcctgtat gaggatttgc ttatgtctga aggagaagat     5220

gatgaggaag atgctgggag tgatgaagaa ggagacaatc ctttctctgc tatccagctg     5280

agtgaaagtg gaagtgactc tgatgtggga tctggtggaa taagacccaa acaaccccgc     5340

atgcttcagg agaacacaag gatggacatg gaaaatgaag aaagcatgat gtcctatgag     5400

ggagacggtg gggaggcttc ccatggtttg gaggatagca acatcagtta tgggagctat     5460

gaggagcctg atcccaagtc gaacacccaa gacacaagct tcagcagcat cggtgggtat     5520

gaggtatcag aggaggaaga agatgaggag gaggaagagc agcgctctgg gccgagcgta     5580

ctaagccagg tccacctgtc agaggacgag gaggacagtg aggatttcca ctccattgct     5640

ggggacagtg acttggactc tgatgaatga ggcttccttt gggcctcctt ggtcagcctt     5700

ccctgttctc cagcctaggt ggttcacctt tccccaattt gttcatattt gtacagtatc     5760

tgatcctgaa atcatgaaat taactaacac cttagccttt ttaaaagtag taagtaaatg     5820

ataataaatc acctctccta atcttcctgg ggcaatgtca ccctttgatt taaaacaaag     5880

caaccccctt tcccctacca ctacggaaaa gagcaagctc atttttccgt gtcctccttt     5940

atttaactcc atttattgct tttggtataa tttttccctg gggaaggagg ggaaattatg     6000

aaagaactag taactttatg tcctcttgat gtattaggaa atttccggcc aggcgtggtg     6060

gctcacacct gtaatctcag cactctggga ggccgaggcg ggcagatcac ctgaggtcag     6120

aagttcgaga ccagcttggc caacatggcg aaaccgcatc tctactaaaa atacaaaaat     6180

tagccaggtg tggtggcgta tgcctgttaa tcctagctac tcgggaggct gaggcaggag     6240

aattacttga acccgggagg cagaggttgc agtgagtgga ggtcacgcca ctgcactcca     6300

gcctgggcga aagagtgaga ttcagtctca aaaaaaaaaa aatttccaag catggtatca     6360

tctcactttt ctaatttaca ggctggagca gatgagagcc ctcctgctgg gacagagaat     6420

tgggttctag tggactctgt gctacactta aacctgtgag acaaaccgcc cattatttta     6480

ttatttaatt atgcaatgcc tagttcctaa atggattgga ggcaaattac cgtaaatttt     6540

gaaacagcct atatgtcaga aatgataatg ttgccaccta aatgttttct gtccccccca     6600

ccctccccag gggaaatggt aggaaaatgg taagtttctt agggcaaaga ctgtgtcttc     6660

tgtttctttt catgcttagg atatggttct gtgcatagta ggtactcagt aaatgttcct     6720

agaatcataa aatcctcaac agatatgtta ctgagcatct gcttttcatg ataagcactc     6780

tatcagatcc ttgggatgca aaggtaaata agacaaatcc cttttaccca aagagctcac     6840

catcaagttg ggggagggaa agtggaattc aaaacatgtt aataaatcat catagtactg     6900

tgagataagt gcaattaaga agctagttat aaagtatagg ggaaatagag gagtaatcat     6960

gtctgaaaag tcaggaaagt cttcctagag gtaattttta agctgattgt tttagaatta     7020

gtagaagctt gccagatgga aaagtccagg caaagtgtaa catgaatggg aaaggccaca     7080

gtctagaaat ggcagagtgt gttcctagtt tgtttgtttg tttgtttgta cctgccttgt     7140

tccaggaagg atttaatgtg gtttatattc cagtccttta atgctggaag ggctgagatg     7200

agactgaaag atgggcagga agtatatcat cacaagcttt gtgtttgatg ttaatgtgta     7260

tgatttttat attatgggaa ataagctctt agaggagtga tataatcagg tttgtgtttt     7320

agaaatctgt gtaatgaatg aatgaagaaa gaaattgaag aatcatgtaa catatgtgat     7380

cgcatttttg taaaagaacc atgtgtgttt atatgtgttt atatatatac ttgtgtatgc     7440

aaaggtaaaa gtctgaaagg atatatgcta actgttcaca atgataaccc cccaggaatg     7500

ggattggagg ggagggggct tctgtgtttg ttatgtatgc tgggtgggat attgtgcttt     7560

tatttctata ttgtttgaat ttttttacag tatgtattat ttttgtaata aaaattttaa     7620

aaaattccaa aaaaaaaaaa aaaaaa                                          7646


<210>  484
<211>  1872
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Gly Pro Gly Cys Asp Leu Leu Leu Arg Thr Ala Ala Thr Ile Thr 
1               5                   10                  15      


Ala Ala Ala Ile Met Ser Asp Thr Asp Ser Asp Glu Asp Ser Ala Gly 
            20                  25                  30          


Gly Gly Pro Phe Ser Leu Ala Gly Phe Leu Phe Gly Asn Ile Asn Gly 
        35                  40                  45              


Ala Gly Gln Leu Glu Gly Glu Ser Val Leu Asp Asp Glu Cys Lys Lys 
    50                  55                  60                  


His Leu Ala Gly Leu Gly Ala Leu Gly Leu Gly Ser Leu Ile Thr Glu 
65                  70                  75                  80  


Leu Thr Ala Asn Glu Glu Leu Thr Gly Thr Asp Gly Ala Leu Val Asn 
                85                  90                  95      


Asp Glu Gly Trp Val Arg Ser Thr Glu Asp Ala Val Asp Tyr Ser Asp 
            100                 105                 110         


Ile Asn Glu Val Ala Glu Asp Glu Ser Arg Arg Tyr Gln Gln Thr Met 
        115                 120                 125             


Gly Ser Leu Gln Pro Leu Cys His Ser Asp Tyr Asp Glu Asp Asp Tyr 
    130                 135                 140                 


Asp Ala Asp Cys Glu Asp Ile Asp Cys Lys Leu Met Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Pro Gly Pro Met Lys Lys Asp Lys Asp Gln Asp Ser Ile Thr 
                165                 170                 175     


Gly Glu Lys Val Asp Phe Ser Ser Ser Ser Asp Ser Glu Ser Glu Met 
            180                 185                 190         


Gly Pro Gln Glu Ala Thr Gln Ala Glu Ser Glu Asp Gly Lys Leu Thr 
        195                 200                 205             


Leu Pro Leu Ala Gly Ile Met Gln His Asp Ala Thr Lys Leu Leu Pro 
    210                 215                 220                 


Ser Val Thr Glu Leu Phe Pro Glu Phe Arg Pro Gly Lys Val Leu Arg 
225                 230                 235                 240 


Phe Leu Arg Leu Phe Gly Pro Gly Lys Asn Val Pro Ser Val Trp Arg 
                245                 250                 255     


Ser Ala Arg Arg Lys Arg Lys Lys Lys His Arg Glu Leu Ile Gln Glu 
            260                 265                 270         


Glu Gln Ile Gln Glu Val Glu Cys Ser Val Glu Ser Glu Val Ser Gln 
        275                 280                 285             


Lys Ser Leu Trp Asn Tyr Asp Tyr Ala Pro Pro Pro Pro Pro Glu Gln 
    290                 295                 300                 


Cys Leu Ser Asp Asp Glu Ile Thr Met Met Ala Pro Val Glu Ser Lys 
305                 310                 315                 320 


Phe Ser Gln Ser Thr Gly Asp Ile Asp Lys Val Thr Asp Thr Lys Pro 
                325                 330                 335     


Arg Val Ala Glu Trp Arg Tyr Gly Pro Ala Arg Leu Trp Tyr Asp Met 
            340                 345                 350         


Leu Gly Val Pro Glu Asp Gly Ser Gly Phe Asp Tyr Gly Phe Lys Leu 
        355                 360                 365             


Arg Lys Thr Glu His Glu Pro Val Ile Lys Ser Arg Met Ile Glu Glu 
    370                 375                 380                 


Phe Arg Lys Leu Glu Glu Asn Asn Gly Thr Asp Leu Leu Ala Asp Glu 
385                 390                 395                 400 


Asn Phe Leu Met Val Thr Gln Leu His Trp Glu Asp Asp Ile Ile Trp 
                405                 410                 415     


Asp Gly Glu Asp Val Lys His Lys Gly Thr Lys Pro Gln Arg Ala Ser 
            420                 425                 430         


Leu Ala Gly Trp Leu Pro Ser Ser Met Thr Arg Asn Ala Met Ala Tyr 
        435                 440                 445             


Asn Val Gln Gln Gly Phe Ala Ala Thr Leu Asp Asp Asp Lys Pro Trp 
    450                 455                 460                 


Tyr Ser Ile Phe Pro Ile Asp Asn Glu Asp Leu Val Tyr Gly Arg Trp 
465                 470                 475                 480 


Glu Asp Asn Ile Ile Trp Asp Ala Gln Ala Met Pro Arg Leu Leu Glu 
                485                 490                 495     


Pro Pro Val Leu Thr Leu Asp Pro Asn Asp Glu Asn Leu Ile Leu Glu 
            500                 505                 510         


Ile Pro Asp Glu Lys Glu Glu Ala Thr Ser Asn Ser Pro Ser Lys Glu 
        515                 520                 525             


Ser Lys Lys Glu Ser Ser Leu Lys Lys Ser Arg Ile Leu Leu Gly Lys 
    530                 535                 540                 


Thr Gly Val Ile Lys Glu Glu Pro Gln Gln Asn Met Ser Gln Pro Glu 
545                 550                 555                 560 


Val Lys Asp Pro Trp Asn Leu Ser Asn Asp Glu Tyr Tyr Tyr Pro Lys 
                565                 570                 575     


Gln Gln Gly Leu Arg Gly Thr Phe Gly Gly Asn Ile Ile Gln His Ser 
            580                 585                 590         


Ile Pro Ala Val Glu Leu Arg Gln Pro Phe Phe Pro Thr His Met Gly 
        595                 600                 605             


Pro Ile Lys Leu Arg Gln Phe His Arg Pro Pro Leu Lys Lys Tyr Ser 
    610                 615                 620                 


Phe Gly Ala Leu Ser Gln Pro Gly Pro His Ser Val Gln Pro Leu Leu 
625                 630                 635                 640 


Lys His Ile Lys Lys Lys Ala Lys Met Arg Glu Gln Glu Arg Gln Ala 
                645                 650                 655     


Ser Gly Gly Gly Glu Met Phe Phe Met Arg Thr Pro Gln Asp Leu Thr 
            660                 665                 670         


Gly Lys Asp Gly Asp Leu Ile Leu Ala Glu Tyr Ser Glu Glu Asn Gly 
        675                 680                 685             


Pro Leu Met Met Gln Val Gly Met Ala Thr Lys Ile Lys Asn Tyr Tyr 
    690                 695                 700                 


Lys Arg Lys Pro Gly Lys Asp Pro Gly Ala Pro Asp Cys Lys Tyr Gly 
705                 710                 715                 720 


Glu Thr Val Tyr Cys His Thr Ser Pro Phe Leu Gly Ser Leu His Pro 
                725                 730                 735     


Gly Gln Leu Leu Gln Ala Phe Glu Asn Asn Leu Phe Arg Ala Pro Ile 
            740                 745                 750         


Tyr Leu His Lys Met Pro Glu Thr Asp Phe Leu Ile Ile Arg Thr Arg 
        755                 760                 765             


Gln Gly Tyr Tyr Ile Arg Glu Leu Val Asp Ile Phe Val Val Gly Gln 
    770                 775                 780                 


Gln Cys Pro Leu Phe Glu Val Pro Gly Pro Asn Ser Lys Arg Ala Asn 
785                 790                 795                 800 


Thr His Ile Arg Asp Phe Leu Gln Val Phe Ile Tyr Arg Leu Phe Trp 
                805                 810                 815     


Lys Ser Lys Asp Arg Pro Arg Arg Ile Arg Met Glu Asp Ile Lys Lys 
            820                 825                 830         


Ala Phe Pro Ser His Ser Glu Ser Ser Ile Arg Lys Arg Leu Lys Leu 
        835                 840                 845             


Cys Ala Asp Phe Lys Arg Thr Gly Met Asp Ser Asn Trp Trp Val Leu 
    850                 855                 860                 


Lys Ser Asp Phe Arg Leu Pro Thr Glu Glu Glu Ile Arg Ala Met Val 
865                 870                 875                 880 


Ser Pro Glu Gln Cys Cys Ala Tyr Tyr Ser Met Ile Ala Ala Glu Gln 
                885                 890                 895     


Arg Leu Lys Asp Ala Gly Tyr Gly Glu Lys Ser Phe Phe Ala Pro Glu 
            900                 905                 910         


Glu Glu Asn Glu Glu Asp Phe Gln Met Lys Ile Asp Asp Glu Val Arg 
        915                 920                 925             


Thr Ala Pro Trp Asn Thr Thr Arg Ala Phe Ile Ala Ala Met Lys Gly 
    930                 935                 940                 


Lys Cys Leu Leu Glu Val Thr Gly Val Ala Asp Pro Thr Gly Cys Gly 
945                 950                 955                 960 


Glu Gly Phe Ser Tyr Val Lys Ile Pro Asn Lys Pro Thr Gln Gln Lys 
                965                 970                 975     


Asp Asp Lys Glu Pro Gln Pro Val Lys Lys Thr Val Thr Gly Thr Asp 
            980                 985                 990         


Ala Asp Leu Arg Arg Leu Ser Leu  Lys Asn Ala Lys Gln  Leu Leu Arg 
        995                 1000                 1005             


Lys Phe  Gly Val Pro Glu Glu  Glu Ile Lys Lys Leu  Ser Arg Trp 
    1010                 1015                 1020             


Glu Val  Ile Asp Val Val Arg  Thr Met Ser Thr Glu  Gln Ala Arg 
    1025                 1030                 1035             


Ser Gly  Glu Gly Pro Met Ser  Lys Phe Ala Arg Gly  Ser Arg Phe 
    1040                 1045                 1050             


Ser Val  Ala Glu His Gln Glu  Arg Tyr Lys Glu Glu  Cys Gln Arg 
    1055                 1060                 1065             


Ile Phe  Asp Leu Gln Asn Lys  Val Leu Ser Ser Thr  Glu Val Leu 
    1070                 1075                 1080             


Ser Thr  Asp Thr Asp Ser Ser  Ser Ala Glu Asp Ser  Asp Phe Glu 
    1085                 1090                 1095             


Glu Met  Gly Lys Asn Ile Glu  Asn Met Leu Gln Asn  Lys Lys Thr 
    1100                 1105                 1110             


Ser Ser  Gln Leu Ser Arg Glu  Arg Glu Glu Gln Glu  Arg Lys Glu 
    1115                 1120                 1125             


Leu Gln  Arg Met Leu Leu Ala  Ala Gly Ser Ala Ala  Ser Gly Asn 
    1130                 1135                 1140             


Asn His  Arg Asp Asp Asp Thr  Ala Ser Val Thr Ser  Leu Asn Ser 
    1145                 1150                 1155             


Ser Ala  Thr Gly Arg Cys Leu  Lys Ile Tyr Arg Thr  Phe Arg Asp 
    1160                 1165                 1170             


Glu Glu  Gly Lys Glu Tyr Val  Arg Cys Glu Thr Val  Arg Lys Pro 
    1175                 1180                 1185             


Ala Val  Ile Asp Ala Tyr Val  Arg Ile Arg Thr Thr  Lys Asp Glu 
    1190                 1195                 1200             


Glu Phe  Ile Arg Lys Phe Ala  Leu Phe Asp Glu Gln  His Arg Glu 
    1205                 1210                 1215             


Glu Met  Arg Lys Glu Arg Arg  Arg Ile Gln Glu Gln  Leu Arg Arg 
    1220                 1225                 1230             


Leu Lys  Arg Asn Gln Glu Lys  Glu Lys Leu Lys Gly  Pro Pro Glu 
    1235                 1240                 1245             


Lys Lys  Pro Lys Lys Met Lys  Glu Arg Pro Asp Leu  Lys Leu Lys 
    1250                 1255                 1260             


Cys Gly  Ala Cys Gly Ala Ile  Gly His Met Arg Thr  Asn Lys Phe 
    1265                 1270                 1275             


Cys Pro  Leu Tyr Tyr Gln Thr  Asn Ala Pro Pro Ser  Asn Pro Val 
    1280                 1285                 1290             


Ala Met  Thr Glu Glu Gln Glu  Glu Glu Leu Glu Lys  Thr Val Ile 
    1295                 1300                 1305             


His Asn  Asp Asn Glu Glu Leu  Ile Lys Val Glu Gly  Thr Lys Ile 
    1310                 1315                 1320             


Val Leu  Gly Lys Gln Leu Ile  Glu Ser Ala Asp Glu  Val Arg Arg 
    1325                 1330                 1335             


Lys Ser  Leu Val Leu Lys Phe  Pro Lys Gln Gln Leu  Pro Pro Lys 
    1340                 1345                 1350             


Lys Lys  Arg Arg Val Gly Thr  Thr Val His Cys Asp  Tyr Leu Asn 
    1355                 1360                 1365             


Arg Pro  His Lys Ser Ile His  Arg Arg Arg Thr Asp  Pro Met Val 
    1370                 1375                 1380             


Thr Leu  Ser Ser Ile Leu Glu  Ser Ile Ile Asn Asp  Met Arg Asp 
    1385                 1390                 1395             


Leu Pro  Asn Thr Tyr Pro Phe  His Thr Pro Val Asn  Ala Lys Val 
    1400                 1405                 1410             


Val Lys  Asp Tyr Tyr Lys Ile  Ile Thr Arg Pro Met  Asp Leu Gln 
    1415                 1420                 1425             


Thr Leu  Arg Glu Asn Val Arg  Lys Arg Leu Tyr Pro  Ser Arg Glu 
    1430                 1435                 1440             


Glu Phe  Arg Glu His Leu Glu  Leu Ile Val Lys Asn  Ser Ala Thr 
    1445                 1450                 1455             


Tyr Asn  Gly Pro Lys His Ser  Leu Thr Gln Ile Ser  Gln Ser Met 
    1460                 1465                 1470             


Leu Asp  Leu Cys Asp Glu Lys  Leu Lys Glu Lys Glu  Asp Lys Leu 
    1475                 1480                 1485             


Ala Arg  Leu Glu Lys Ala Ile  Asn Pro Leu Leu Asp  Asp Asp Asp 
    1490                 1495                 1500             


Gln Val  Ala Phe Ser Phe Ile  Leu Asp Asn Ile Val  Thr Gln Lys 
    1505                 1510                 1515             


Met Met  Ala Val Pro Asp Ser  Trp Pro Phe His His  Pro Val Asn 
    1520                 1525                 1530             


Lys Lys  Phe Val Pro Asp Tyr  Tyr Lys Val Ile Val  Asn Pro Met 
    1535                 1540                 1545             


Asp Leu  Glu Thr Ile Arg Lys  Asn Ile Ser Lys His  Lys Tyr Gln 
    1550                 1555                 1560             


Ser Arg  Glu Ser Phe Leu Asp  Asp Val Asn Leu Ile  Leu Ala Asn 
    1565                 1570                 1575             


Ser Val  Lys Tyr Asn Gly Pro  Glu Ser Gln Tyr Thr  Lys Thr Ala 
    1580                 1585                 1590             


Gln Glu  Ile Val Asn Val Cys  Tyr Gln Thr Leu Thr  Glu Tyr Asp 
    1595                 1600                 1605             


Glu His  Leu Thr Gln Leu Glu  Lys Asp Ile Cys Thr  Ala Lys Glu 
    1610                 1615                 1620             


Ala Ala  Leu Glu Glu Ala Glu  Leu Glu Ser Leu Asp  Pro Met Thr 
    1625                 1630                 1635             


Pro Gly  Pro Tyr Thr Pro Gln  Pro Pro Asp Leu Tyr  Asp Thr Asn 
    1640                 1645                 1650             


Thr Ser  Leu Ser Met Ser Arg  Asp Ala Ser Val Phe  Gln Asp Glu 
    1655                 1660                 1665             


Ser Asn  Met Ser Val Leu Asp  Ile Pro Ser Ala Thr  Pro Glu Lys 
    1670                 1675                 1680             


Gln Val  Thr Gln Glu Gly Glu  Asp Gly Asp Gly Asp  Leu Ala Asp 
    1685                 1690                 1695             


Glu Glu  Glu Gly Thr Val Gln  Gln Pro Gln Ala Ser  Val Leu Tyr 
    1700                 1705                 1710             


Glu Asp  Leu Leu Met Ser Glu  Gly Glu Asp Asp Glu  Glu Asp Ala 
    1715                 1720                 1725             


Gly Ser  Asp Glu Glu Gly Asp  Asn Pro Phe Ser Ala  Ile Gln Leu 
    1730                 1735                 1740             


Ser Glu  Ser Gly Ser Asp Ser  Asp Val Gly Ser Gly  Gly Ile Arg 
    1745                 1750                 1755             


Pro Lys  Gln Pro Arg Met Leu  Gln Glu Asn Thr Arg  Met Asp Met 
    1760                 1765                 1770             


Glu Asn  Glu Glu Ser Met Met  Ser Tyr Glu Gly Asp  Gly Gly Glu 
    1775                 1780                 1785             


Ala Ser  His Gly Leu Glu Asp  Ser Asn Ile Ser Tyr  Gly Ser Tyr 
    1790                 1795                 1800             


Glu Glu  Pro Asp Pro Lys Ser  Asn Thr Gln Asp Thr  Ser Phe Ser 
    1805                 1810                 1815             


Ser Ile  Gly Gly Tyr Glu Val  Ser Glu Glu Glu Glu  Asp Glu Glu 
    1820                 1825                 1830             


Glu Glu  Glu Gln Arg Ser Gly  Pro Ser Val Leu Ser  Gln Val His 
    1835                 1840                 1845             


Leu Ser  Glu Asp Glu Glu Asp  Ser Glu Asp Phe His  Ser Ile Ala 
    1850                 1855                 1860             


Gly Asp  Ser Asp Leu Asp Ser  Asp Glu 
    1865                 1870         


<210>  485
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  485
gatttcggcc tgactattac ttgggccacg gaaatagcca acccttttct tccgcacggt       60

tggaggaggt cggctggtta tcgggagttg gagggctgag gtcgggaggg tggtgtgtac      120

agagctctag gacaccaggc cagtcgcggg ttttgggccg aggcctgggt tacaagcagc      180

aagtgcgcgg ttggggccac tgcgaggccg ttttagaaaa ctgtttaaaa caaagagcaa      240

ttgatggata aatcaggaat agattctctt gaccatgtga catctgatgc tgtggaactt      300

gcaaatcgaa gtgataactc ttctgatagc agcttattta aaactcagtg tatcccttac      360

tcacctaaag gggagaaaag aaaccccatt cgaaaatttg ttcgtacacc tgaaagtgtt      420

cacgcaagtg attcatcaag tgactcatct tttgaaccaa taccattgac tataaaagct      480

atttttgaaa gattcaagaa caggaaaaag agatataaaa aaaagaaaaa gaggaggtac      540

cagccaacag gaagaccacg gggaagacca gaaggaagga gaaatcctat atactcacta      600

atagataaga agaaacaatt tagaagcaga ggatctggct tcccattttt agaatcagag      660

aatgaaaaaa acgcaccttg gagaaaaatt ttaacgtttg agcaagctgt tgcaagagga      720

ttttttaact atattgaaaa actgaagtat gaacaccacc tgaaagaatc attgaagcaa      780

atgaatgttg gtgaagattt agaaaatgaa gattttgaca gtcgtagata caaatttttg      840

gatgatgatg gatccatttc tcctattgag gagtcaacag cagaggatga ggatgcaaca      900

catcttgaag ataacgaatg tgatatcaaa ttggcagggg atagtttcat agtaagttct      960

gaattccctg taagactgag tgtatactta gaagaagagg atattactga agaagctgct     1020

ttgtctaaaa agagagctac aaaagccaaa aatactggac agagaggcct gaaaatgtga     1080

caggatcatg aatgtcaaag gtgaagcata tagaaaaaac gacttcatag aaatgaataa     1140

agataaatgt ggatatatgt accagtctgg tggtgaagaa attctgaaac ccagaacttt     1200

ataacaagaa aaaaaatttt taaccctgtg aagaagtttg tgaaagaaac ttgtgaagta     1260

gtaataatta gaaaaaaaac cattaaaaca ccagagaaaa tacatagaaa aaaaaaaaaa     1320

aaa                                                                   1323


<210>  486
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Asp Lys Ser Gly Ile Asp Ser Leu Asp His Val Thr Ser Asp Ala 
1               5                   10                  15      


Val Glu Leu Ala Asn Arg Ser Asp Asn Ser Ser Asp Ser Ser Leu Phe 
            20                  25                  30          


Lys Thr Gln Cys Ile Pro Tyr Ser Pro Lys Gly Glu Lys Arg Asn Pro 
        35                  40                  45              


Ile Arg Lys Phe Val Arg Thr Pro Glu Ser Val His Ala Ser Asp Ser 
    50                  55                  60                  


Ser Ser Asp Ser Ser Phe Glu Pro Ile Pro Leu Thr Ile Lys Ala Ile 
65                  70                  75                  80  


Phe Glu Arg Phe Lys Asn Arg Lys Lys Arg Tyr Lys Lys Lys Lys Lys 
                85                  90                  95      


Arg Arg Tyr Gln Pro Thr Gly Arg Pro Arg Gly Arg Pro Glu Gly Arg 
            100                 105                 110         


Arg Asn Pro Ile Tyr Ser Leu Ile Asp Lys Lys Lys Gln Phe Arg Ser 
        115                 120                 125             


Arg Gly Ser Gly Phe Pro Phe Leu Glu Ser Glu Asn Glu Lys Asn Ala 
    130                 135                 140                 


Pro Trp Arg Lys Ile Leu Thr Phe Glu Gln Ala Val Ala Arg Gly Phe 
145                 150                 155                 160 


Phe Asn Tyr Ile Glu Lys Leu Lys Tyr Glu His His Leu Lys Glu Ser 
                165                 170                 175     


Leu Lys Gln Met Asn Val Gly Glu Asp Leu Glu Asn Glu Asp Phe Asp 
            180                 185                 190         


Ser Arg Arg Tyr Lys Phe Leu Asp Asp Asp Gly Ser Ile Ser Pro Ile 
        195                 200                 205             


Glu Glu Ser Thr Ala Glu Asp Glu Asp Ala Thr His Leu Glu Asp Asn 
    210                 215                 220                 


Glu Cys Asp Ile Lys Leu Ala Gly Asp Ser Phe Ile Val Ser Ser Glu 
225                 230                 235                 240 


Phe Pro Val Arg Leu Ser Val Tyr Leu Glu Glu Glu Asp Ile Thr Glu 
                245                 250                 255     


Glu Ala Ala Leu Ser Lys Lys Arg Ala Thr Lys Ala Lys Asn Thr Gly 
            260                 265                 270         


Gln Arg Gly Leu Lys Met 
        275             


<210>  487
<211>  6631
<212>  DNA
<213>  Homo sapiens

<400>  487
gagcttccca ggcgcgcggg ccgcgaggtt attagaggtg gagcgcgggg agggcgcgcg       60

gcgggaggcg gccgccgtta cggcgcgagc gtggtcacgt ggccgctggt caccgccgcc      120

accccctccc gccctgttct ctttcaggtc gggccgggcc cggccgcttc cgcgagcgcc      180

ctgcagactg agggagagag agagaaagag gaggggagga ggaggaggat tcagggaata      240

ggagctgggg agcccttctg cgccacagag atggggtctc actctgtcat ccaggctgga      300

atatagtggc acaatcatag cccattgtag cctccatctc aaggactcag gggatcctcc      360

cttctaggcc tcccaagtag ctgggattac aggtagttac ttttggtgac gctgtccagt      420

tcccacaatg tatcattcct tatctgaaac tagacatcct ctgcagccag aagaacaaga      480

agtaggcatt gaccccttgt ccagttactc taacaagtct ggaggagatt caaataaaaa      540

tggaagaaga acaagttcta ctttagactc tgaagggact tttaattcct ataggaaaga      600

atgggaagaa ctatttgtaa acaacaatta cttggcaaca ataaggcaga aggggattaa      660

tgggcagctg agaagcagca ggttccgcag catttgctgg aagctatttc tttgtgttct      720

tcctcaagac aaaagtcaat ggataagtag aattgaagaa ttaagagcat ggtatagcaa      780

cattaaagaa atacatatta ccaacccgag gaaggttgtt ggccaacaag atttgatgat      840

caataatcct ctttcacagg atgaagggag tctttggaac aaattcttcc aagataaaga      900

acttcgatca atgattgaac aagatgtcaa aagaacgttt cctgaaatgc agtttttcca      960

gcaagaaaat gtgagaaaaa ttcttacaga tgttcttttc tgttatgcca gagaaaacga     1020

gcagttgctt tataaacagg gcatgcacga actgttagca cctatagtct ttgtccttca     1080

ctgtgaccac caagcttttc tacatgccag tgagtctgca cagcccagtg aggaaatgaa     1140

aactgtcttg aaccctgagt atctggaaca tgatgcctat gcagtgttct cacaacttat     1200

ggaaactgct gaaccttggt tttcaacttt tgagcatgat ggtcagaagg ggaaagaaac     1260

actgatgact cccattccct ttgctagacc acaagattta gggccaacaa ttgctattgt     1320

tactaaagtc aaccagatcc aggatcatct actgaagaag catgatattg agctttacat     1380

gcacttgaac agactagaaa ttgcaccaca gatatatggg ttaaggtggg tgcggctgct     1440

atttggacga gagttccccc tgcaggacct tctggtggtc tgggatgcct tgtttgcaga     1500

cggcctcagc ctgggtttag tagattatat cttcgtagcc atgttacttt acatccgaga     1560

tgctttgatc tctagtaact accagacctg tctcggcctt ctgatgcatt acccattcat     1620

cggggatgta cactcactga ttcttaaggc tctgttcctt agagatccaa agagaaatcc     1680

aagaccagtg acttatcaat tccatccaaa tttagattat tacaaagcac gaggagcaga     1740

cctcatgaat aaaagccgga ccaatgccaa aggtgctccc ctgaatataa ataaggtctc     1800

taatagcctg attaattttg gaagaaagtt gatttcccca gcaatggctc caggcagtgc     1860

aggtggccct gtacctggag gcaacagcag tagctcctcc tctgttgtaa ttcctaccag     1920

gacctcagca gaggccccaa gccatcactt gcaacagcaa cagcagcagc agaggctgat     1980

gaaatcagaa agcatgcctg tgcaattgaa caaagggcta agttctaaaa acatcagttc     2040

atctccaagc gttgagagtt tgcctggagg aagagaattc actggctctc caccttcatc     2100

tgctactaaa aaagattcct tttttagcaa catctcacgt tctcgctcac acagcaaaac     2160

tatgggcaga aaagaatctg aagaagaatt agaagcccaa atttccttcc ttcaagggca     2220

gttgaatgac ctggatgcca tgtgcaaata ctgtgcaaag gtgatggaca ctcatcttgt     2280

aaatattcaa gatgtgatat tacaagaaaa tttggaaaaa gaagatcaaa ttctggtttc     2340

cctggcagga ttaaaacaga tcaaagacat tctaaaaggt tccctgcgtt ttaaccagag     2400

ccagctagag gccgaagaga acgaacagat caccattgcg gacaaccact actgctccag     2460

cggccagggc cagggccgag gccaaggcca gagcgttcaa atgtcagggg ccattaaaca     2520

ggcctcttca gaaacgccag ggtgcactga tagagggaat tccgatgact tcatcctgat     2580

ttccaaagat gatgatggga gcagtgccag gggctccttc tccggccagg cccagcctct     2640

tcgcaccctc agaagcacct ctgggaaaag ccaggcccca gtctgctccc cactggtgtt     2700

ctcagatcca ctgatgggcc cagcctcagc ttcctccagc aaccccagct ccagtcctga     2760

tgacgacagc agcaaggact ctggcttcac cattgtgagt cccctggaca tctgaccaca     2820

gtgcccagtc ctgccccaca gggatctagc cacccttcag tggccccaag gccagactga     2880

ggctcatcca gtggagaacc ttcttaaacc actgcttcct tcccggcatg cattttgcat     2940

tggtccagcc ctttgaaacc ccttagagag aagcatatat ggccacaaag cacagaggct     3000

taggtttgcc acatgcagac agggctttct gggcccttac ctaatcccca cccgactctt     3060

gctctgagtt agagctgagt tacgtaccca gtatcacact cacagttaga aaagaccgaa     3120

tcacaattta gaatcacttt tcctctgtcc ccttctcccc agctaagaat gtgtggcacc     3180

tccatcagtt atacttagaa ggagcagaaa tagttatttt cgtatcttct atccctcaaa     3240

gcatcagaca tgggaaaatt ggtttatacc aagaaagctt cctctgtgga aatctgtctc     3300

agcctacttt attcctgcat tgggaagcca tatcgcagag ctaaatgcaa tagaatgaac     3360

cagaactagt ggattccagg gctgggggaa aaaaaaaaag aaaaaacctc attactgacc     3420

tctcaaagtt ataaggatct ctgcaaacag gatctaagct taggaataat atttaggtgt     3480

gatatagtgt tagatttttt tgatgtatta aagaatgcat ctccaatcct taggccatat     3540

caactttggc catcaatatc tctccttaaa caattatatt tcacctttta gaatctttca     3600

tagccagaaa acaagattac tgtaagccag ttttagctgc actgatttca aaagatataa     3660

gaatattact atccttcaaa tggaaaatgc gaccttgact ttatgggata aacatctttc     3720

agacagtcag ttttctagtc aggtttctct ggtttcagag ctgtatatac ctgtcaactg     3780

aggaataaag ggaaaaaccc aagttcattc ccacccaaag tcagaatccc tcattggcct     3840

taaggtagca gtcataagac agagaattgg acctagagtc ccttctgtgg ggaataagga     3900

tacctagaga acattccaca tgccaagagg atgcaggatt tctacacaac cccttccctt     3960

cttggaagtc aagtgtaggt actgcagggc ctgtgctcag ctgtgaaccc cgtatcctgg     4020

gccccactgc cgggaccggg tctgacatgc cagtgccttc ctgggctgag cacagattag     4080

agactctccc ccttgtcagt cagcacctta ggaaaccatg atgggcacag agcatcacat     4140

gagctgtttc tctccttaaa gaagatccct ggaaaggatg cttttcctct cctttgcctg     4200

cgcaggaatt ctaacaggag tgggtgagga tggcagaggg acacagtgcc tgtctcgcct     4260

ccatcaggga gagcagccat gccagggatg actagctctt tgagcctgtc ctcagaggat     4320

ggcgaggcag ccgggcagtg gaggccttca tggtaacaaa tgaaagctca gtatagagga     4380

acagacactg tttacgtccc tcccactgct aaccttatat atctctatag acaaatgtga     4440

taatgacatg atttcccacc tgccctccaa gaaaatggtg actcactctc aagtcagcta     4500

ctgtagagag ggttctaatt ggttctgcaa tttgctctta aactctagca gggaactctc     4560

ctcttaccac atcagcatgt aaggtgaata ataactggtt ttgccagaca gcaggttgtc     4620

tgaccttcaa ccactgggca attgcctggc agatgcacac agtagctccc tggcttctgg     4680

ctctgagtgt tcctctcagc acctctgagt aagctgctgc caagcacata tccctatgac     4740

aacactttgt aaaagccgcg gggcccccat acagcgagtg accttgcaac tgtgcagggt     4800

tgccattggt cactttctca ccttgggaag gtgtcagtgt tttcagttct aaggtaagag     4860

gtgtagagct gttcccacca gggctctggg acagactgga aaggaccaca gacctggcca     4920

tccctgggca gcagggccag tgtcacctgc tgacctctag tatttccttt gccctagagc     4980

tagagtcatg atagctgagg gtcactcgcc ctgcaagagt cactaggcac ccaccatgcc     5040

aataaggctc tccgctggct ccctgcagtt ggctgggtgt ttaatagtca ctgaaaactc     5100

ccagccctgc tgcacactag aggcaggtcc tctcggtcct ctccatcctg tgcttctgtg     5160

gcccccagca agctcaccac ctccttggag gagagagaca tacaaggaca gtgggtcatg     5220

ggtagtacca gcctcaaatt cccacaggct catactcaga caattgtatt actgccttat     5280

gttttttaag tgttttttta aattcttcat agttgagtat tatttgcaat tttattagtt     5340

acagtgctat taaagaatat gtgctccttt ttattatatt atcagatact tatgtttaat     5400

tgtacatttt ttaaatcctg aatatattgt gttttgttaa caaatgtaat cagtggaacc     5460

cttcttacgt tttgattatt agcagttaaa tacattttgt atacatgaag cttagattaa     5520

ttcccatcat catcatctcc tgtttttata tgtgtcccta tgtgtttcat gcattcctct     5580

ttgatcagat tggaatttga gttaaaattt agctttgtac attacgtgtg agagttacag     5640

actagcaagt ctaattactt tgccttacct tgagtgtatg ccacagggtc agataacaca     5700

ttaaacattt agttacactg gattactctt ccaaagctga cctcctgcta atgttcagag     5760

gtaactgcaa tccggaaaga aataatatca ctgcagaaag aatgtgactc taaaaataaa     5820

ccaggacctc cctgtgattt gccttgcctg cagatgacca gttgactctt gtgctgtcag     5880

ccctggggtt gctaaggaag ctgcttcagg gagttggggg ttagttgccc gctctcaaca     5940

ggaatgcctc ctctactttg tcagagatgc tgaacaaata tcaaactctg tggcagtcat     6000

gctggcctcc taagaataac ctgtgagtca gagttgatgc acattatttt tgtttttatt     6060

ttattttttt aaggaactgc tccaagggtt cattatagaa caggagtgtg tacggaggac     6120

ttaggtcccc acatagagtg gccgttctgt ggcggctcca accaattcca tccctccttt     6180

cctgcggaca cacacctggc ccctggcccc tgccctgtgt gtctggagga ggggcactgg     6240

ggaggctgtg gagcagagag aagaggccgg atacattgag gatggcacct ggcaagccag     6300

gcttccttct caaaggccag actgctttct cagtgttact tactaaagct ctctttttat     6360

actgttaaaa agatatataa agttcgtata aacaggcttg agaccacttt gatgtaaaag     6420

ctgtcatagt agtttttctc acagtggcac aattcatttg attgatggaa tattcagtga     6480

cgccatgtat gccctatcgc ttttttctca tccatcttta tgctataact catactgatt     6540

taagaaatga tttctccttt tggcaaagcg accccattca atatggttat aataaaagac     6600

taatgtcaaa ctgagaaaaa aaaaaaaaaa a                                    6631


<210>  488
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Tyr His Ser Leu Ser Glu Thr Arg His Pro Leu Gln Pro Glu Glu 
1               5                   10                  15      


Gln Glu Val Gly Ile Asp Pro Leu Ser Ser Tyr Ser Asn Lys Ser Gly 
            20                  25                  30          


Gly Asp Ser Asn Lys Asn Gly Arg Arg Thr Ser Ser Thr Leu Asp Ser 
        35                  40                  45              


Glu Gly Thr Phe Asn Ser Tyr Arg Lys Glu Trp Glu Glu Leu Phe Val 
    50                  55                  60                  


Asn Asn Asn Tyr Leu Ala Thr Ile Arg Gln Lys Gly Ile Asn Gly Gln 
65                  70                  75                  80  


Leu Arg Ser Ser Arg Phe Arg Ser Ile Cys Trp Lys Leu Phe Leu Cys 
                85                  90                  95      


Val Leu Pro Gln Asp Lys Ser Gln Trp Ile Ser Arg Ile Glu Glu Leu 
            100                 105                 110         


Arg Ala Trp Tyr Ser Asn Ile Lys Glu Ile His Ile Thr Asn Pro Arg 
        115                 120                 125             


Lys Val Val Gly Gln Gln Asp Leu Met Ile Asn Asn Pro Leu Ser Gln 
    130                 135                 140                 


Asp Glu Gly Ser Leu Trp Asn Lys Phe Phe Gln Asp Lys Glu Leu Arg 
145                 150                 155                 160 


Ser Met Ile Glu Gln Asp Val Lys Arg Thr Phe Pro Glu Met Gln Phe 
                165                 170                 175     


Phe Gln Gln Glu Asn Val Arg Lys Ile Leu Thr Asp Val Leu Phe Cys 
            180                 185                 190         


Tyr Ala Arg Glu Asn Glu Gln Leu Leu Tyr Lys Gln Gly Met His Glu 
        195                 200                 205             


Leu Leu Ala Pro Ile Val Phe Val Leu His Cys Asp His Gln Ala Phe 
    210                 215                 220                 


Leu His Ala Ser Glu Ser Ala Gln Pro Ser Glu Glu Met Lys Thr Val 
225                 230                 235                 240 


Leu Asn Pro Glu Tyr Leu Glu His Asp Ala Tyr Ala Val Phe Ser Gln 
                245                 250                 255     


Leu Met Glu Thr Ala Glu Pro Trp Phe Ser Thr Phe Glu His Asp Gly 
            260                 265                 270         


Gln Lys Gly Lys Glu Thr Leu Met Thr Pro Ile Pro Phe Ala Arg Pro 
        275                 280                 285             


Gln Asp Leu Gly Pro Thr Ile Ala Ile Val Thr Lys Val Asn Gln Ile 
    290                 295                 300                 


Gln Asp His Leu Leu Lys Lys His Asp Ile Glu Leu Tyr Met His Leu 
305                 310                 315                 320 


Asn Arg Leu Glu Ile Ala Pro Gln Ile Tyr Gly Leu Arg Trp Val Arg 
                325                 330                 335     


Leu Leu Phe Gly Arg Glu Phe Pro Leu Gln Asp Leu Leu Val Val Trp 
            340                 345                 350         


Asp Ala Leu Phe Ala Asp Gly Leu Ser Leu Gly Leu Val Asp Tyr Ile 
        355                 360                 365             


Phe Val Ala Met Leu Leu Tyr Ile Arg Asp Ala Leu Ile Ser Ser Asn 
    370                 375                 380                 


Tyr Gln Thr Cys Leu Gly Leu Leu Met His Tyr Pro Phe Ile Gly Asp 
385                 390                 395                 400 


Val His Ser Leu Ile Leu Lys Ala Leu Phe Leu Arg Asp Pro Lys Arg 
                405                 410                 415     


Asn Pro Arg Pro Val Thr Tyr Gln Phe His Pro Asn Leu Asp Tyr Tyr 
            420                 425                 430         


Lys Ala Arg Gly Ala Asp Leu Met Asn Lys Ser Arg Thr Asn Ala Lys 
        435                 440                 445             


Gly Ala Pro Leu Asn Ile Asn Lys Val Ser Asn Ser Leu Ile Asn Phe 
    450                 455                 460                 


Gly Arg Lys Leu Ile Ser Pro Ala Met Ala Pro Gly Ser Ala Gly Gly 
465                 470                 475                 480 


Pro Val Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Val Val Ile Pro 
                485                 490                 495     


Thr Arg Thr Ser Ala Glu Ala Pro Ser His His Leu Gln Gln Gln Gln 
            500                 505                 510         


Gln Gln Gln Arg Leu Met Lys Ser Glu Ser Met Pro Val Gln Leu Asn 
        515                 520                 525             


Lys Gly Leu Ser Ser Lys Asn Ile Ser Ser Ser Pro Ser Val Glu Ser 
    530                 535                 540                 


Leu Pro Gly Gly Arg Glu Phe Thr Gly Ser Pro Pro Ser Ser Ala Thr 
545                 550                 555                 560 


Lys Lys Asp Ser Phe Phe Ser Asn Ile Ser Arg Ser Arg Ser His Ser 
                565                 570                 575     


Lys Thr Met Gly Arg Lys Glu Ser Glu Glu Glu Leu Glu Ala Gln Ile 
            580                 585                 590         


Ser Phe Leu Gln Gly Gln Leu Asn Asp Leu Asp Ala Met Cys Lys Tyr 
        595                 600                 605             


Cys Ala Lys Val Met Asp Thr His Leu Val Asn Ile Gln Asp Val Ile 
    610                 615                 620                 


Leu Gln Glu Asn Leu Glu Lys Glu Asp Gln Ile Leu Val Ser Leu Ala 
625                 630                 635                 640 


Gly Leu Lys Gln Ile Lys Asp Ile Leu Lys Gly Ser Leu Arg Phe Asn 
                645                 650                 655     


Gln Ser Gln Leu Glu Ala Glu Glu Asn Glu Gln Ile Thr Ile Ala Asp 
            660                 665                 670         


Asn His Tyr Cys Ser Ser Gly Gln Gly Gln Gly Arg Gly Gln Gly Gln 
        675                 680                 685             


Ser Val Gln Met Ser Gly Ala Ile Lys Gln Ala Ser Ser Glu Thr Pro 
    690                 695                 700                 


Gly Cys Thr Asp Arg Gly Asn Ser Asp Asp Phe Ile Leu Ile Ser Lys 
705                 710                 715                 720 


Asp Asp Asp Gly Ser Ser Ala Arg Gly Ser Phe Ser Gly Gln Ala Gln 
                725                 730                 735     


Pro Leu Arg Thr Leu Arg Ser Thr Ser Gly Lys Ser Gln Ala Pro Val 
            740                 745                 750         


Cys Ser Pro Leu Val Phe Ser Asp Pro Leu Met Gly Pro Ala Ser Ala 
        755                 760                 765             


Ser Ser Ser Asn Pro Ser Ser Ser Pro Asp Asp Asp Ser Ser Lys Asp 
    770                 775                 780                 


Ser Gly Phe Thr Ile Val Ser Pro Leu Asp Ile 
785                 790                 795 


<210>  489
<211>  6534
<212>  DNA
<213>  Homo sapiens

<400>  489
gtattgagtc accataagtg gacaaggaag gagcttctaa cagacctcat tgtacataca       60

aaattacaat catgaatgta aaggaaagca cactggaact gcttgcagct gactgcgacc      120

ttgagtctca gcttctgcat ctgtgaaatg aagatactgg tctgtgatat cagtatcaag      180

ataaaagttt ggaatgggag aaaaattctc aaagcctgaa agaaaatctg tagttacttt      240

tggtgacgct gtccagttcc cacaatgtat cattccttat ctgaaactag acatcctctg      300

cagccagaag aacaagaagt aggcattgac cccttgtcca gttactctaa caagtctgga      360

ggagattcaa ataaaaatgg aagaagaaca agttctactt tagactctga agggactttt      420

aattcctata ggaaagaatg ggaagaacta tttgtaaaca acaattactt ggcaacaata      480

aggcagaagg ggattaatgg gcagctgaga agcagcaggt tccgcagcat ttgctggaag      540

ctatttcttt gtgttcttcc tcaagacaaa agtcaatgga taagtagaat tgaagaatta      600

agagcatggt atagcaacat taaagaaata catattacca acccgaggaa ggttgttggc      660

caacaagatt tgatgatcaa taatcctctt tcacaggatg aagggagtct ttggaacaaa      720

ttcttccaag ataaagaact tcgatcaatg attgaacaag atgtcaaaag aacgtttcct      780

gaaatgcagt ttttccagca agaaaatgtg agaaaaattc ttacagatgt tcttttctgt      840

tatgccagag aaaacgagca gttgctttat aaacagggca tgcacgaact gttagcacct      900

atagtctttg tccttcactg tgaccaccaa gcttttctac atgccagtga gtctgcacag      960

cccagtgagg aaatgaaaac tgtcttgaac cctgagtatc tggaacatga tgcctatgca     1020

gtgttctcac aacttatgga aactgctgaa ccttggtttt caacttttga gcatgatggt     1080

cagaagggga aagaaacact gatgactccc attccctttg ctagaccaca agatttaggg     1140

ccaacaattg ctattgttac taaagtcaac cagatccagg atcatctact gaagaagcat     1200

gatattgagc tttacatgca cttgaacaga ctagaaattg caccacagat atatgggtta     1260

aggtgggtgc ggctgctatt tggacgagag ttccccctgc aggaccttct ggtggtctgg     1320

gatgccttgt ttgcagacgg cctcagcctg ggtttagtag attatatctt cgtagccatg     1380

ttactttaca tccgagatgc tttgatctct agtaactacc agacctgtct cggccttctg     1440

atgcattacc cattcatcgg ggatgtacac tcactgattc ttaaggctct gttccttaga     1500

gatccaaaga gaaatccaag accagtgact tatcaattcc atccaaattt agattattac     1560

aaagcacgag gagcagacct catgaataaa agccggacca atgccaaagg tgctcccctg     1620

aatataaata aggtctctaa tagcctgatt aattttggaa gaaagttgat ttccccagca     1680

atggctccag gcagtgcagg tggccctgta cctggaggca acagcagtag ctcctcctct     1740

gttgtaattc ctaccaggac ctcagcagag gccccaagcc atcacttgca acagcaacag     1800

cagcagcaga ggctgatgaa atcagaaagc atgcctgtgc aattgaacaa aggcgatgta     1860

gttacaggaa gcgatgctca ggtttctgtt cctgtccaga ctctaactga cctccaaggg     1920

ctaagttcta aaaacatcag ttcatctcca agcgttgaga gtttgcctgg aggaagagaa     1980

ttcactggct ctccaccttc atctgctact aaaaaagatt ccttttttag caacatctca     2040

cgttctcgct cacacagcaa aactatgggc agaaaagaat ctgaagaaga attagaagcc     2100

caaatttcct tccttcaagg gcagttgaat gacctggatg ccatgtgcaa atactgtgca     2160

aaggtgatgg acactcatct tgtaaatatt caagatgtga tattacaaga aaatttggaa     2220

aaagaagatc aaattctggt ttccctggca ggattaaaac agatcaaaga cattctaaaa     2280

ggttccctgc gttttaacca gagccagcta gaggccgaag agaacgaaca gatcaccatt     2340

gcggacaacc actactgctc cagcggccag ggccagggcc gaggccaagg ccagagcgtt     2400

caaatgtcag gggccattaa acaggcctct tcagaaacgc cagggtgcac tgatagaggg     2460

aattccgatg acttcatcct gatttccaaa gatgatgatg ggagcagtgc caggggctcc     2520

ttctccggcc aggcccagcc tcttcgcacc ctcagaagca cctctgggaa aagccaggcc     2580

ccagtctgct ccccactggt gttctcagat ccactgatgg gcccagcctc agcttcctcc     2640

agcaacccca gctccagtcc tgatgacgac agcagcaagg actctggctt caccattgtg     2700

agtcccctgg acatctgacc acagtgccca gtcctgcccc acagggatct agccaccctt     2760

cagtggcccc aaggccagac tgaggctcat ccagtggaga accttcttaa accactgctt     2820

ccttcccggc atgcattttg cattggtcca gccctttgaa accccttaga gagaagcata     2880

tatggccaca aagcacagag gcttaggttt gccacatgca gacagggctt tctgggccct     2940

tacctaatcc ccacccgact cttgctctga gttagagctg agttacgtac ccagtatcac     3000

actcacagtt agaaaagacc gaatcacaat ttagaatcac ttttcctctg tccccttctc     3060

cccagctaag aatgtgtggc acctccatca gttatactta gaaggagcag aaatagttat     3120

tttcgtatct tctatccctc aaagcatcag acatgggaaa attggtttat accaagaaag     3180

cttcctctgt ggaaatctgt ctcagcctac tttattcctg cattgggaag ccatatcgca     3240

gagctaaatg caatagaatg aaccagaact agtggattcc agggctgggg gaaaaaaaaa     3300

aagaaaaaac ctcattactg acctctcaaa gttataagga tctctgcaaa caggatctaa     3360

gcttaggaat aatatttagg tgtgatatag tgttagattt ttttgatgta ttaaagaatg     3420

catctccaat ccttaggcca tatcaacttt ggccatcaat atctctcctt aaacaattat     3480

atttcacctt ttagaatctt tcatagccag aaaacaagat tactgtaagc cagttttagc     3540

tgcactgatt tcaaaagata taagaatatt actatccttc aaatggaaaa tgcgaccttg     3600

actttatggg ataaacatct ttcagacagt cagttttcta gtcaggtttc tctggtttca     3660

gagctgtata tacctgtcaa ctgaggaata aagggaaaaa cccaagttca ttcccaccca     3720

aagtcagaat ccctcattgg ccttaaggta gcagtcataa gacagagaat tggacctaga     3780

gtcccttctg tggggaataa ggatacctag agaacattcc acatgccaag aggatgcagg     3840

atttctacac aaccccttcc cttcttggaa gtcaagtgta ggtactgcag ggcctgtgct     3900

cagctgtgaa ccccgtatcc tgggccccac tgccgggacc gggtctgaca tgccagtgcc     3960

ttcctgggct gagcacagat tagagactct cccccttgtc agtcagcacc ttaggaaacc     4020

atgatgggca cagagcatca catgagctgt ttctctcctt aaagaagatc cctggaaagg     4080

atgcttttcc tctcctttgc ctgcgcagga attctaacag gagtgggtga ggatggcaga     4140

gggacacagt gcctgtctcg cctccatcag ggagagcagc catgccaggg atgactagct     4200

ctttgagcct gtcctcagag gatggcgagg cagccgggca gtggaggcct tcatggtaac     4260

aaatgaaagc tcagtataga ggaacagaca ctgtttacgt ccctcccact gctaacctta     4320

tatatctcta tagacaaatg tgataatgac atgatttccc acctgccctc caagaaaatg     4380

gtgactcact ctcaagtcag ctactgtaga gagggttcta attggttctg caatttgctc     4440

ttaaactcta gcagggaact ctcctcttac cacatcagca tgtaaggtga ataataactg     4500

gttttgccag acagcaggtt gtctgacctt caaccactgg gcaattgcct ggcagatgca     4560

cacagtagct ccctggcttc tggctctgag tgttcctctc agcacctctg agtaagctgc     4620

tgccaagcac atatccctat gacaacactt tgtaaaagcc gcggggcccc catacagcga     4680

gtgaccttgc aactgtgcag ggttgccatt ggtcactttc tcaccttggg aaggtgtcag     4740

tgttttcagt tctaaggtaa gaggtgtaga gctgttccca ccagggctct gggacagact     4800

ggaaaggacc acagacctgg ccatccctgg gcagcagggc cagtgtcacc tgctgacctc     4860

tagtatttcc tttgccctag agctagagtc atgatagctg agggtcactc gccctgcaag     4920

agtcactagg cacccaccat gccaataagg ctctccgctg gctccctgca gttggctggg     4980

tgtttaatag tcactgaaaa ctcccagccc tgctgcacac tagaggcagg tcctctcggt     5040

cctctccatc ctgtgcttct gtggccccca gcaagctcac cacctccttg gaggagagag     5100

acatacaagg acagtgggtc atgggtagta ccagcctcaa attcccacag gctcatactc     5160

agacaattgt attactgcct tatgtttttt aagtgttttt ttaaattctt catagttgag     5220

tattatttgc aattttatta gttacagtgc tattaaagaa tatgtgctcc tttttattat     5280

attatcagat acttatgttt aattgtacat tttttaaatc ctgaatatat tgtgttttgt     5340

taacaaatgt aatcagtgga acccttctta cgttttgatt attagcagtt aaatacattt     5400

tgtatacatg aagcttagat taattcccat catcatcatc tcctgttttt atatgtgtcc     5460

ctatgtgttt catgcattcc tctttgatca gattggaatt tgagttaaaa tttagctttg     5520

tacattacgt gtgagagtta cagactagca agtctaatta ctttgcctta ccttgagtgt     5580

atgccacagg gtcagataac acattaaaca tttagttaca ctggattact cttccaaagc     5640

tgacctcctg ctaatgttca gaggtaactg caatccggaa agaaataata tcactgcaga     5700

aagaatgtga ctctaaaaat aaaccaggac ctccctgtga tttgccttgc ctgcagatga     5760

ccagttgact cttgtgctgt cagccctggg gttgctaagg aagctgcttc agggagttgg     5820

gggttagttg cccgctctca acaggaatgc ctcctctact ttgtcagaga tgctgaacaa     5880

atatcaaact ctgtggcagt catgctggcc tcctaagaat aacctgtgag tcagagttga     5940

tgcacattat ttttgttttt attttatttt tttaaggaac tgctccaagg gttcattata     6000

gaacaggagt gtgtacggag gacttaggtc cccacataga gtggccgttc tgtggcggct     6060

ccaaccaatt ccatccctcc tttcctgcgg acacacacct ggcccctggc ccctgccctg     6120

tgtgtctgga ggaggggcac tggggaggct gtggagcaga gagaagaggc cggatacatt     6180

gaggatggca cctggcaagc caggcttcct tctcaaaggc cagactgctt tctcagtgtt     6240

acttactaaa gctctctttt tatactgtta aaaagatata taaagttcgt ataaacaggc     6300

ttgagaccac tttgatgtaa aagctgtcat agtagttttt ctcacagtgg cacaattcat     6360

ttgattgatg gaatattcag tgacgccatg tatgccctat cgcttttttc tcatccatct     6420

ttatgctata actcatactg atttaagaaa tgatttctcc ttttggcaaa gcgaccccat     6480

tcaatatggt tataataaaa gactaatgtc aaactgagaa aaaaaaaaaa aaaa           6534


<210>  490
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Tyr His Ser Leu Ser Glu Thr Arg His Pro Leu Gln Pro Glu Glu 
1               5                   10                  15      


Gln Glu Val Gly Ile Asp Pro Leu Ser Ser Tyr Ser Asn Lys Ser Gly 
            20                  25                  30          


Gly Asp Ser Asn Lys Asn Gly Arg Arg Thr Ser Ser Thr Leu Asp Ser 
        35                  40                  45              


Glu Gly Thr Phe Asn Ser Tyr Arg Lys Glu Trp Glu Glu Leu Phe Val 
    50                  55                  60                  


Asn Asn Asn Tyr Leu Ala Thr Ile Arg Gln Lys Gly Ile Asn Gly Gln 
65                  70                  75                  80  


Leu Arg Ser Ser Arg Phe Arg Ser Ile Cys Trp Lys Leu Phe Leu Cys 
                85                  90                  95      


Val Leu Pro Gln Asp Lys Ser Gln Trp Ile Ser Arg Ile Glu Glu Leu 
            100                 105                 110         


Arg Ala Trp Tyr Ser Asn Ile Lys Glu Ile His Ile Thr Asn Pro Arg 
        115                 120                 125             


Lys Val Val Gly Gln Gln Asp Leu Met Ile Asn Asn Pro Leu Ser Gln 
    130                 135                 140                 


Asp Glu Gly Ser Leu Trp Asn Lys Phe Phe Gln Asp Lys Glu Leu Arg 
145                 150                 155                 160 


Ser Met Ile Glu Gln Asp Val Lys Arg Thr Phe Pro Glu Met Gln Phe 
                165                 170                 175     


Phe Gln Gln Glu Asn Val Arg Lys Ile Leu Thr Asp Val Leu Phe Cys 
            180                 185                 190         


Tyr Ala Arg Glu Asn Glu Gln Leu Leu Tyr Lys Gln Gly Met His Glu 
        195                 200                 205             


Leu Leu Ala Pro Ile Val Phe Val Leu His Cys Asp His Gln Ala Phe 
    210                 215                 220                 


Leu His Ala Ser Glu Ser Ala Gln Pro Ser Glu Glu Met Lys Thr Val 
225                 230                 235                 240 


Leu Asn Pro Glu Tyr Leu Glu His Asp Ala Tyr Ala Val Phe Ser Gln 
                245                 250                 255     


Leu Met Glu Thr Ala Glu Pro Trp Phe Ser Thr Phe Glu His Asp Gly 
            260                 265                 270         


Gln Lys Gly Lys Glu Thr Leu Met Thr Pro Ile Pro Phe Ala Arg Pro 
        275                 280                 285             


Gln Asp Leu Gly Pro Thr Ile Ala Ile Val Thr Lys Val Asn Gln Ile 
    290                 295                 300                 


Gln Asp His Leu Leu Lys Lys His Asp Ile Glu Leu Tyr Met His Leu 
305                 310                 315                 320 


Asn Arg Leu Glu Ile Ala Pro Gln Ile Tyr Gly Leu Arg Trp Val Arg 
                325                 330                 335     


Leu Leu Phe Gly Arg Glu Phe Pro Leu Gln Asp Leu Leu Val Val Trp 
            340                 345                 350         


Asp Ala Leu Phe Ala Asp Gly Leu Ser Leu Gly Leu Val Asp Tyr Ile 
        355                 360                 365             


Phe Val Ala Met Leu Leu Tyr Ile Arg Asp Ala Leu Ile Ser Ser Asn 
    370                 375                 380                 


Tyr Gln Thr Cys Leu Gly Leu Leu Met His Tyr Pro Phe Ile Gly Asp 
385                 390                 395                 400 


Val His Ser Leu Ile Leu Lys Ala Leu Phe Leu Arg Asp Pro Lys Arg 
                405                 410                 415     


Asn Pro Arg Pro Val Thr Tyr Gln Phe His Pro Asn Leu Asp Tyr Tyr 
            420                 425                 430         


Lys Ala Arg Gly Ala Asp Leu Met Asn Lys Ser Arg Thr Asn Ala Lys 
        435                 440                 445             


Gly Ala Pro Leu Asn Ile Asn Lys Val Ser Asn Ser Leu Ile Asn Phe 
    450                 455                 460                 


Gly Arg Lys Leu Ile Ser Pro Ala Met Ala Pro Gly Ser Ala Gly Gly 
465                 470                 475                 480 


Pro Val Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Val Val Ile Pro 
                485                 490                 495     


Thr Arg Thr Ser Ala Glu Ala Pro Ser His His Leu Gln Gln Gln Gln 
            500                 505                 510         


Gln Gln Gln Arg Leu Met Lys Ser Glu Ser Met Pro Val Gln Leu Asn 
        515                 520                 525             


Lys Gly Asp Val Val Thr Gly Ser Asp Ala Gln Val Ser Val Pro Val 
    530                 535                 540                 


Gln Thr Leu Thr Asp Leu Gln Gly Leu Ser Ser Lys Asn Ile Ser Ser 
545                 550                 555                 560 


Ser Pro Ser Val Glu Ser Leu Pro Gly Gly Arg Glu Phe Thr Gly Ser 
                565                 570                 575     


Pro Pro Ser Ser Ala Thr Lys Lys Asp Ser Phe Phe Ser Asn Ile Ser 
            580                 585                 590         


Arg Ser Arg Ser His Ser Lys Thr Met Gly Arg Lys Glu Ser Glu Glu 
        595                 600                 605             


Glu Leu Glu Ala Gln Ile Ser Phe Leu Gln Gly Gln Leu Asn Asp Leu 
    610                 615                 620                 


Asp Ala Met Cys Lys Tyr Cys Ala Lys Val Met Asp Thr His Leu Val 
625                 630                 635                 640 


Asn Ile Gln Asp Val Ile Leu Gln Glu Asn Leu Glu Lys Glu Asp Gln 
                645                 650                 655     


Ile Leu Val Ser Leu Ala Gly Leu Lys Gln Ile Lys Asp Ile Leu Lys 
            660                 665                 670         


Gly Ser Leu Arg Phe Asn Gln Ser Gln Leu Glu Ala Glu Glu Asn Glu 
        675                 680                 685             


Gln Ile Thr Ile Ala Asp Asn His Tyr Cys Ser Ser Gly Gln Gly Gln 
    690                 695                 700                 


Gly Arg Gly Gln Gly Gln Ser Val Gln Met Ser Gly Ala Ile Lys Gln 
705                 710                 715                 720 


Ala Ser Ser Glu Thr Pro Gly Cys Thr Asp Arg Gly Asn Ser Asp Asp 
                725                 730                 735     


Phe Ile Leu Ile Ser Lys Asp Asp Asp Gly Ser Ser Ala Arg Gly Ser 
            740                 745                 750         


Phe Ser Gly Gln Ala Gln Pro Leu Arg Thr Leu Arg Ser Thr Ser Gly 
        755                 760                 765             


Lys Ser Gln Ala Pro Val Cys Ser Pro Leu Val Phe Ser Asp Pro Leu 
    770                 775                 780                 


Met Gly Pro Ala Ser Ala Ser Ser Ser Asn Pro Ser Ser Ser Pro Asp 
785                 790                 795                 800 


Asp Asp Ser Ser Lys Asp Ser Gly Phe Thr Ile Val Ser Pro Leu Asp 
                805                 810                 815     


Ile 
    


<210>  491
<211>  7869
<212>  DNA
<213>  Homo sapiens

<400>  491
tgactgcatc acctggtctg tgaattttcc attagaagct tggtgtgctg ttaggtgaaa       60

gacttgctca gctatgcgtc attgggtttt atcaacatat aggcgaaaaa aatcctggtc      120

tctgagtgta cagctgagat gaaaatttct tttattggag gaagtattga gtgtgtgctc      180

tcaaatgcgg cctcagttga gtagtgcatt cctgagtttt ggaagcaaat ttgcaaacaa      240

ttgagagtcg tacagtgggt gttctaactg gattcaggtt ttttctaatg taattttttc      300

acacgtaaat taaaaagttt agaaatgtca cacataactt cataacactt tatggagaaa      360

tggttgtact tttaattttt ttctttttat ttatactcca actgactgag cagaggttgt      420

acttctaaat aactttgtgg aagtttttag taccataatt tttataattt tcattccagt      480

cctttgatat ttatgacagt acttctgaag cgcttactga gtgccggaca ctgttgtaag      540

tgctttacgg aacttgactt tttttttttt ttgagacgga ctctcgctct gtcgcccagg      600

ctggagtgca gtggtgcagt ggctcgatct cggctcactg ccacctctcc ctcatggttt      660

caaacacttc tcctgcctca gcctcccagg tagccaggat tatagccgcc cgccaccact      720

cccgactaat tttattttgt atgttctttt ttagtagaga cggaggagtt tcaccatgtt      780

ggccaggctg gtatcgacct cctgacctca agtgatgtgt ccatctcggc ctcccaaggt      840

gctggaatta caggtgtgag ccactgtgct cggcctacct tttttttttt gttttttgtt      900

tttttgaaaa ggagtttcgc tcttgtccag gctggagtat aatggtgcga tctcagctca      960

ccgcaatctc cgcctcccag attcaagcga ttctcctgcc tcagcctcct caggagctgg     1020

gattacaggc gcccaccgcc atgcccggct aatttttgta tttttagtag agacggggtt     1080

tcactatatt ggccaggctg gtctcgaact gctgacctca agtaatccgc ctgcctcagc     1140

ctcccaaagt gctgggatta cagacgtgat ccaccaggat cacaccaggc cgcgcctggc     1200

ctgctttcat tttaaaagtc aaatttgtca tccgcctcag tgcttgtaat cttttctgag     1260

tgagatactg aaatttgcag tttcgttttg cttgcacttg ttcactggac cagtagtcac     1320

tgttaaatgt aaaagtatct acttcctctg aaagtttttt attcctttat ttcctgcctg     1380

ggcttgtcct ccaccctaca tgtatgcgta gtagatttag tgtttgttat cctaaccttt     1440

aggtttaggg attgactggg tttctgactt tttatttggc caatgaggac gatacagaaa     1500

atgaagcatt ggtcattatc acattttaac gctgaaaaag taagaaggac aaccccggaa     1560

taaaatgata tcagtatcaa gataaaagtt tggaatggga gaaaaattct caaagcctga     1620

aagaaaatct gtagttactt ttggtgacgc tgtccagttc ccacaatgta tcattcctta     1680

tctgaaacta gacatcctct gcagccagaa gaacaagaag taggcattga ccccttgtcc     1740

agttactcta acaagtctgg aggagattca aataaaaatg gaagaagaac aagttctact     1800

ttagactctg aagggacttt taattcctat aggaaagaat gggaagaact atttgtaaac     1860

aacaattact tggcaacaat aaggcagaag gggattaatg ggcagctgag aagcagcagg     1920

ttccgcagca tttgctggaa gctatttctt tgtgttcttc ctcaagacaa aagtcaatgg     1980

ataagtagaa ttgaagaatt aagagcatgg tatagcaaca ttaaagaaat acatattacc     2040

aacccgagga aggttgttgg ccaacaagat ttgatgatca ataatcctct ttcacaggat     2100

gaagggagtc tttggaacaa attcttccaa gataaagaac ttcgatcaat gattgaacaa     2160

gatgtcaaaa gaacgtttcc tgaaatgcag tttttccagc aagaaaatgt gagaaaaatt     2220

cttacagatg ttcttttctg ttatgccaga gaaaacgagc agttgcttta taaacagggc     2280

atgcacgaac tgttagcacc tatagtcttt gtccttcact gtgaccacca agcttttcta     2340

catgccagtg agtctgcaca gcccagtgag gaaatgaaaa ctgtcttgaa ccctgagtat     2400

ctggaacatg atgcctatgc agtgttctca caacttatgg aaactgctga accttggttt     2460

tcaacttttg agcatgatgg tcagaagggg aaagaaacac tgatgactcc cattcccttt     2520

gctagaccac aagatttagg gccaacaatt gctattgtta ctaaagtcaa ccagatccag     2580

gatcatctac tgaagaagca tgatattgag ctttacatgc acttgaacag actagaaatt     2640

gcaccacaga tatatgggtt aaggtgggtg cggctgctat ttggacgaga gttccccctg     2700

caggaccttc tggtggtctg ggatgccttg tttgcagacg gcctcagcct gggtttagta     2760

gattatatct tcgtagccat gttactttac atccgagatg ctttgatctc tagtaactac     2820

cagacctgtc tcggccttct gatgcattac ccattcatcg gggatgtaca ctcactgatt     2880

cttaaggctc tgttccttag agatccaaag agaaatccaa gaccagtgac ttatcaattc     2940

catccaaatt tagattatta caaagcacga ggagcagacc tcatgaataa aagccggacc     3000

aatgccaaag gtgctcccct gaatataaat aaggtctcta atagcctgat taattttgga     3060

agaaagttga tttccccagc aatggctcca ggcagtgcag gtggccctgt acctggaggc     3120

aacagcagta gctcctcctc tgttgtaatt cctaccagga cctcagcaga ggccccaagc     3180

catcacttgc aacagcaaca gcagcagcag aggctgatga aatcagaaag catgcctgtg     3240

caattgaaca aagggctaag ttctaaaaac atcagttcat ctccaagcgt tgagagtttg     3300

cctggaggaa gagaattcac tggctctcca ccttcatctg ctactaaaaa agattccttt     3360

tttagcaaca tctcacgttc tcgctcacac agcaaaacta tgggcagaaa agaatctgaa     3420

gaagaattag aagcccaaat ttccttcctt caagggcagt tgaatgacct ggatgccatg     3480

tgcaaatact gtgcaaaggt gatggacact catcttgtaa atattcaaga tgtgatatta     3540

caagaaaatt tggaaaaaga agatcaaatt ctggtttccc tggcaggatt aaaacagatc     3600

aaagacattc taaaaggttc cctgcgtttt aaccagagcc agctagaggc cgaagagaac     3660

gaacagatca ccattgcgga caaccactac tgctccagcg gccagggcca gggccgaggc     3720

caaggccaga gcgttcaaat gtcaggggcc attaaacagg cctcttcaga aacgccaggg     3780

tgcactgata gagggaattc cgatgacttc atcctgattt ccaaagatga tgatgggagc     3840

agtgccaggg gctccttctc cggccaggcc cagcctcttc gcaccctcag aagcacctct     3900

gggaaaagcc aggccccagt ctgctcccca ctggtgttct cagatccact gatgggccca     3960

gcctcagctt cctccagcaa ccccagctcc agtcctgatg acgacagcag caaggactct     4020

ggcttcacca ttgtgagtcc cctggacatc tgaccacagt gcccagtcct gccccacagg     4080

gatctagcca cccttcagtg gccccaaggc cagactgagg ctcatccagt ggagaacctt     4140

cttaaaccac tgcttccttc ccggcatgca ttttgcattg gtccagccct ttgaaacccc     4200

ttagagagaa gcatatatgg ccacaaagca cagaggctta ggtttgccac atgcagacag     4260

ggctttctgg gcccttacct aatccccacc cgactcttgc tctgagttag agctgagtta     4320

cgtacccagt atcacactca cagttagaaa agaccgaatc acaatttaga atcacttttc     4380

ctctgtcccc ttctccccag ctaagaatgt gtggcacctc catcagttat acttagaagg     4440

agcagaaata gttattttcg tatcttctat ccctcaaagc atcagacatg ggaaaattgg     4500

tttataccaa gaaagcttcc tctgtggaaa tctgtctcag cctactttat tcctgcattg     4560

ggaagccata tcgcagagct aaatgcaata gaatgaacca gaactagtgg attccagggc     4620

tgggggaaaa aaaaaaagaa aaaacctcat tactgacctc tcaaagttat aaggatctct     4680

gcaaacagga tctaagctta ggaataatat ttaggtgtga tatagtgtta gatttttttg     4740

atgtattaaa gaatgcatct ccaatcctta ggccatatca actttggcca tcaatatctc     4800

tccttaaaca attatatttc accttttaga atctttcata gccagaaaac aagattactg     4860

taagccagtt ttagctgcac tgatttcaaa agatataaga atattactat ccttcaaatg     4920

gaaaatgcga ccttgacttt atgggataaa catctttcag acagtcagtt ttctagtcag     4980

gtttctctgg tttcagagct gtatatacct gtcaactgag gaataaaggg aaaaacccaa     5040

gttcattccc acccaaagtc agaatccctc attggcctta aggtagcagt cataagacag     5100

agaattggac ctagagtccc ttctgtgggg aataaggata cctagagaac attccacatg     5160

ccaagaggat gcaggatttc tacacaaccc cttcccttct tggaagtcaa gtgtaggtac     5220

tgcagggcct gtgctcagct gtgaaccccg tatcctgggc cccactgccg ggaccgggtc     5280

tgacatgcca gtgccttcct gggctgagca cagattagag actctccccc ttgtcagtca     5340

gcaccttagg aaaccatgat gggcacagag catcacatga gctgtttctc tccttaaaga     5400

agatccctgg aaaggatgct tttcctctcc tttgcctgcg caggaattct aacaggagtg     5460

ggtgaggatg gcagagggac acagtgcctg tctcgcctcc atcagggaga gcagccatgc     5520

cagggatgac tagctctttg agcctgtcct cagaggatgg cgaggcagcc gggcagtgga     5580

ggccttcatg gtaacaaatg aaagctcagt atagaggaac agacactgtt tacgtccctc     5640

ccactgctaa ccttatatat ctctatagac aaatgtgata atgacatgat ttcccacctg     5700

ccctccaaga aaatggtgac tcactctcaa gtcagctact gtagagaggg ttctaattgg     5760

ttctgcaatt tgctcttaaa ctctagcagg gaactctcct cttaccacat cagcatgtaa     5820

ggtgaataat aactggtttt gccagacagc aggttgtctg accttcaacc actgggcaat     5880

tgcctggcag atgcacacag tagctccctg gcttctggct ctgagtgttc ctctcagcac     5940

ctctgagtaa gctgctgcca agcacatatc cctatgacaa cactttgtaa aagccgcggg     6000

gcccccatac agcgagtgac cttgcaactg tgcagggttg ccattggtca ctttctcacc     6060

ttgggaaggt gtcagtgttt tcagttctaa ggtaagaggt gtagagctgt tcccaccagg     6120

gctctgggac agactggaaa ggaccacaga cctggccatc cctgggcagc agggccagtg     6180

tcacctgctg acctctagta tttcctttgc cctagagcta gagtcatgat agctgagggt     6240

cactcgccct gcaagagtca ctaggcaccc accatgccaa taaggctctc cgctggctcc     6300

ctgcagttgg ctgggtgttt aatagtcact gaaaactccc agccctgctg cacactagag     6360

gcaggtcctc tcggtcctct ccatcctgtg cttctgtggc ccccagcaag ctcaccacct     6420

ccttggagga gagagacata caaggacagt gggtcatggg tagtaccagc ctcaaattcc     6480

cacaggctca tactcagaca attgtattac tgccttatgt tttttaagtg tttttttaaa     6540

ttcttcatag ttgagtatta tttgcaattt tattagttac agtgctatta aagaatatgt     6600

gctccttttt attatattat cagatactta tgtttaattg tacatttttt aaatcctgaa     6660

tatattgtgt tttgttaaca aatgtaatca gtggaaccct tcttacgttt tgattattag     6720

cagttaaata cattttgtat acatgaagct tagattaatt cccatcatca tcatctcctg     6780

tttttatatg tgtccctatg tgtttcatgc attcctcttt gatcagattg gaatttgagt     6840

taaaatttag ctttgtacat tacgtgtgag agttacagac tagcaagtct aattactttg     6900

ccttaccttg agtgtatgcc acagggtcag ataacacatt aaacatttag ttacactgga     6960

ttactcttcc aaagctgacc tcctgctaat gttcagaggt aactgcaatc cggaaagaaa     7020

taatatcact gcagaaagaa tgtgactcta aaaataaacc aggacctccc tgtgatttgc     7080

cttgcctgca gatgaccagt tgactcttgt gctgtcagcc ctggggttgc taaggaagct     7140

gcttcaggga gttgggggtt agttgcccgc tctcaacagg aatgcctcct ctactttgtc     7200

agagatgctg aacaaatatc aaactctgtg gcagtcatgc tggcctccta agaataacct     7260

gtgagtcaga gttgatgcac attatttttg tttttatttt atttttttaa ggaactgctc     7320

caagggttca ttatagaaca ggagtgtgta cggaggactt aggtccccac atagagtggc     7380

cgttctgtgg cggctccaac caattccatc cctcctttcc tgcggacaca cacctggccc     7440

ctggcccctg ccctgtgtgt ctggaggagg ggcactgggg aggctgtgga gcagagagaa     7500

gaggccggat acattgagga tggcacctgg caagccaggc ttccttctca aaggccagac     7560

tgctttctca gtgttactta ctaaagctct ctttttatac tgttaaaaag atatataaag     7620

ttcgtataaa caggcttgag accactttga tgtaaaagct gtcatagtag tttttctcac     7680

agtggcacaa ttcatttgat tgatggaata ttcagtgacg ccatgtatgc cctatcgctt     7740

ttttctcatc catctttatg ctataactca tactgattta agaaatgatt tctccttttg     7800

gcaaagcgac cccattcaat atggttataa taaaagacta atgtcaaact gagaaaaaaa     7860

aaaaaaaaa                                                             7869


<210>  492
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Tyr His Ser Leu Ser Glu Thr Arg His Pro Leu Gln Pro Glu Glu 
1               5                   10                  15      


Gln Glu Val Gly Ile Asp Pro Leu Ser Ser Tyr Ser Asn Lys Ser Gly 
            20                  25                  30          


Gly Asp Ser Asn Lys Asn Gly Arg Arg Thr Ser Ser Thr Leu Asp Ser 
        35                  40                  45              


Glu Gly Thr Phe Asn Ser Tyr Arg Lys Glu Trp Glu Glu Leu Phe Val 
    50                  55                  60                  


Asn Asn Asn Tyr Leu Ala Thr Ile Arg Gln Lys Gly Ile Asn Gly Gln 
65                  70                  75                  80  


Leu Arg Ser Ser Arg Phe Arg Ser Ile Cys Trp Lys Leu Phe Leu Cys 
                85                  90                  95      


Val Leu Pro Gln Asp Lys Ser Gln Trp Ile Ser Arg Ile Glu Glu Leu 
            100                 105                 110         


Arg Ala Trp Tyr Ser Asn Ile Lys Glu Ile His Ile Thr Asn Pro Arg 
        115                 120                 125             


Lys Val Val Gly Gln Gln Asp Leu Met Ile Asn Asn Pro Leu Ser Gln 
    130                 135                 140                 


Asp Glu Gly Ser Leu Trp Asn Lys Phe Phe Gln Asp Lys Glu Leu Arg 
145                 150                 155                 160 


Ser Met Ile Glu Gln Asp Val Lys Arg Thr Phe Pro Glu Met Gln Phe 
                165                 170                 175     


Phe Gln Gln Glu Asn Val Arg Lys Ile Leu Thr Asp Val Leu Phe Cys 
            180                 185                 190         


Tyr Ala Arg Glu Asn Glu Gln Leu Leu Tyr Lys Gln Gly Met His Glu 
        195                 200                 205             


Leu Leu Ala Pro Ile Val Phe Val Leu His Cys Asp His Gln Ala Phe 
    210                 215                 220                 


Leu His Ala Ser Glu Ser Ala Gln Pro Ser Glu Glu Met Lys Thr Val 
225                 230                 235                 240 


Leu Asn Pro Glu Tyr Leu Glu His Asp Ala Tyr Ala Val Phe Ser Gln 
                245                 250                 255     


Leu Met Glu Thr Ala Glu Pro Trp Phe Ser Thr Phe Glu His Asp Gly 
            260                 265                 270         


Gln Lys Gly Lys Glu Thr Leu Met Thr Pro Ile Pro Phe Ala Arg Pro 
        275                 280                 285             


Gln Asp Leu Gly Pro Thr Ile Ala Ile Val Thr Lys Val Asn Gln Ile 
    290                 295                 300                 


Gln Asp His Leu Leu Lys Lys His Asp Ile Glu Leu Tyr Met His Leu 
305                 310                 315                 320 


Asn Arg Leu Glu Ile Ala Pro Gln Ile Tyr Gly Leu Arg Trp Val Arg 
                325                 330                 335     


Leu Leu Phe Gly Arg Glu Phe Pro Leu Gln Asp Leu Leu Val Val Trp 
            340                 345                 350         


Asp Ala Leu Phe Ala Asp Gly Leu Ser Leu Gly Leu Val Asp Tyr Ile 
        355                 360                 365             


Phe Val Ala Met Leu Leu Tyr Ile Arg Asp Ala Leu Ile Ser Ser Asn 
    370                 375                 380                 


Tyr Gln Thr Cys Leu Gly Leu Leu Met His Tyr Pro Phe Ile Gly Asp 
385                 390                 395                 400 


Val His Ser Leu Ile Leu Lys Ala Leu Phe Leu Arg Asp Pro Lys Arg 
                405                 410                 415     


Asn Pro Arg Pro Val Thr Tyr Gln Phe His Pro Asn Leu Asp Tyr Tyr 
            420                 425                 430         


Lys Ala Arg Gly Ala Asp Leu Met Asn Lys Ser Arg Thr Asn Ala Lys 
        435                 440                 445             


Gly Ala Pro Leu Asn Ile Asn Lys Val Ser Asn Ser Leu Ile Asn Phe 
    450                 455                 460                 


Gly Arg Lys Leu Ile Ser Pro Ala Met Ala Pro Gly Ser Ala Gly Gly 
465                 470                 475                 480 


Pro Val Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Val Val Ile Pro 
                485                 490                 495     


Thr Arg Thr Ser Ala Glu Ala Pro Ser His His Leu Gln Gln Gln Gln 
            500                 505                 510         


Gln Gln Gln Arg Leu Met Lys Ser Glu Ser Met Pro Val Gln Leu Asn 
        515                 520                 525             


Lys Gly Leu Ser Ser Lys Asn Ile Ser Ser Ser Pro Ser Val Glu Ser 
    530                 535                 540                 


Leu Pro Gly Gly Arg Glu Phe Thr Gly Ser Pro Pro Ser Ser Ala Thr 
545                 550                 555                 560 


Lys Lys Asp Ser Phe Phe Ser Asn Ile Ser Arg Ser Arg Ser His Ser 
                565                 570                 575     


Lys Thr Met Gly Arg Lys Glu Ser Glu Glu Glu Leu Glu Ala Gln Ile 
            580                 585                 590         


Ser Phe Leu Gln Gly Gln Leu Asn Asp Leu Asp Ala Met Cys Lys Tyr 
        595                 600                 605             


Cys Ala Lys Val Met Asp Thr His Leu Val Asn Ile Gln Asp Val Ile 
    610                 615                 620                 


Leu Gln Glu Asn Leu Glu Lys Glu Asp Gln Ile Leu Val Ser Leu Ala 
625                 630                 635                 640 


Gly Leu Lys Gln Ile Lys Asp Ile Leu Lys Gly Ser Leu Arg Phe Asn 
                645                 650                 655     


Gln Ser Gln Leu Glu Ala Glu Glu Asn Glu Gln Ile Thr Ile Ala Asp 
            660                 665                 670         


Asn His Tyr Cys Ser Ser Gly Gln Gly Gln Gly Arg Gly Gln Gly Gln 
        675                 680                 685             


Ser Val Gln Met Ser Gly Ala Ile Lys Gln Ala Ser Ser Glu Thr Pro 
    690                 695                 700                 


Gly Cys Thr Asp Arg Gly Asn Ser Asp Asp Phe Ile Leu Ile Ser Lys 
705                 710                 715                 720 


Asp Asp Asp Gly Ser Ser Ala Arg Gly Ser Phe Ser Gly Gln Ala Gln 
                725                 730                 735     


Pro Leu Arg Thr Leu Arg Ser Thr Ser Gly Lys Ser Gln Ala Pro Val 
            740                 745                 750         


Cys Ser Pro Leu Val Phe Ser Asp Pro Leu Met Gly Pro Ala Ser Ala 
        755                 760                 765             


Ser Ser Ser Asn Pro Ser Ser Ser Pro Asp Asp Asp Ser Ser Lys Asp 
    770                 775                 780                 


Ser Gly Phe Thr Ile Val Ser Pro Leu Asp Ile 
785                 790                 795 


<210>  493
<211>  5105
<212>  DNA
<213>  Homo sapiens

<400>  493
gtgtgcccgg gggcgggcgg gcggcagggc agcaggaccg cggccggtgc cccagccgaa       60

gccggagtcg cgcggccggg agcacgggcg ccggcatagt acaatgaggc agccagcgga      120

tcttggagcc tgagcccttg tgaagccggc aatgacaagt ctgtatggtc gccatgccga      180

gaaaaccact gacatgccaa aaccatcagc ccctaaagtg cacgtgcaga ggtccgtgtc      240

ccgagatacc atcgccattc acttctcggc atccggcgag gaggaggagg aagaggagga      300

ggagttcagg gagtactttg aggaggggct ggatgaccaa agcattgtaa cagggctgga      360

agccaaggaa gacctctatc ttgaacccca agttggccat gaccccgccg gccctgctgc      420

ctcgcctgtc ctggcagatg gactgtccgt gtcccaggcc cctgccattt tgcccgtctc      480

caagaacact gtaaagctgt tggagtcccc tgttccagca gcacaagtat taagtacagt      540

gccattggct gtgtccccag ggtcgtcttc gtcggggccc ttagctagct ctcccagtgt      600

gtcatccctt tctgagcaga aaaccagttc ttcctcccca ttgtcctctc cttctaagtc      660

tcccatcctc tcatccagtg cctcaacctc caccctttcc agtgcaaaac ccttcatgag      720

ccttgtgaag tccctgtcga ccgaggtgga gccaaaagaa tccccacacc ccgcaaggca      780

caggcacttg atgaagacat tagtcaagtc tctgtccacg gacacttccc ggcaggagtc      840

ggatacagtg tcctataagc cacctgattc caaactgaac ttacacctgt tcaagcagtt      900

cacacagccc cgaaacacag gtggagattc caaaactgca ccttcttccc cactgacttc      960

tccctctgat actcgttcct tttttaaagt gcccgaaatg gaggctaaaa ttgaagatac     1020

taaacgacgc ctttcagaag tcatctatga gccttttcag ctccttagta aaattatagg     1080

ggaagaaagt ggcagccata ggcccaaagc cttatcttca agtgcttcag aactctccaa     1140

tctgtccagc ttgaatgggc acttggaaag caataacaac tacagcatca aggaggagga     1200

gtgtgattct gagggggatg gctacggaag tgattccaac atccccagaa gtgaccaccc     1260

aaagtccact ggtgagccca caagagagat agaactgaaa agttcccagg ggagcagtct     1320

gaaggattta ggcctgaaga caagttctct agttctggag aaatgttctt tgtctgcctt     1380

agtgagcaaa gaagatgaag agttttgtga actgtacact gaggacttcg atttggaaac     1440

ggagggggag agtaaagttg ataagctctc agatattcct ctcaagccag aggtgctcgc     1500

ggaagatggt gtggtccttg acagtgagga cgaggtggac tcggccgtgc agcacccgga     1560

attgccagtg aagacgttgg gcttctttat aatgtgtgtc tatgtgtacc tcatcctccc     1620

cctcccccac tatgtgagtg gactctttct gggaattggc cttggattca tgactgcagt     1680

ttgcgtgatt tggtttttta caccaccaag tgctcataaa tatcacaagt tacacaaaaa     1740

tctgcgacac tggaacacaa gatctctgga tatcaaagaa cctgaaatac tgaagggatg     1800

gatgaatgag atttacaact atgatccaga aacctaccat gcgactttga cacattcagt     1860

ctttgttcga cttgagggtg gaaccttaag actttcaaag cccaataaaa atatatccag     1920

gagggccagc tacaatgaac ccaagccaga ggtcacctac atcagccaga aaatctatga     1980

cctctcagac agcaagattt atcttgtacc taaaactttg gctcgaaagc gaatctggaa     2040

taaaaagtac cccatttgta tcgagcttgg tcagcaagat gactttatgt ctaaagctca     2100

gactgataag gagacttcag aagagaagcc gccagctgag ggaagtgagg accctaagaa     2160

gccaccccgc cctcaggagg gaacaagatc tagccagcga gatcagatac tctatctctt     2220

tgggagaact ggccgagaaa aagaggaatg gtttaggaga tttattctgg catctaagct     2280

aaagtcggaa atcaagaagt catcgggtgt ctctggaggt aaaccagccc ccgtcttctt     2340

ggctccaggg cttttgcctg cacacagcag acacaacagt ccgtccgggc acctgaccca     2400

cagccgcagc agcagcaaag gcagtgtgga ggagatcatg tcacagccaa agcagaagga     2460

gctggcaggc agcgtgcggc agaagatgct tctcgactac agcgtgtaca tgggcaggtg     2520

tgtcccccag gaaagccgaa gcccccagag gagccccctg cagagtgcgg agagcagccc     2580

cacagctggg aagaagttgc cagaggttcc accctctgag gaggaagaac aggaagcctg     2640

ggtgaatgcc ttgcttggaa gaatattttg ggacttctta ggagagaaat actggtctga     2700

tctggtgtct aagaagatcc aaatgaaact cagcaaaata aagctcccct actttatgaa     2760

tgagctcact ctgacggaac ttgacatggg cgtggctgtg ccaaaaatcc tccaggcctt     2820

caagccttac gttgatcacc aaggactctg gattgatttg gaaatgtcct acaatgggtc     2880

ctttctgatg actctcgaga ccaaaatgaa tttgaccaaa ctaggtaaag agcctcttgt     2940

tgaagccctg aaggttggag aaattggcaa agaaggttgc aggccccggg cattctgtct     3000

ggcggacagc gatgaggaat cctccagcgc tggctcctcc gaggaagacg atgccccaga     3060

gcccagcggg ggagacaaac agctcctccc aggggctgaa gggtacgttg gaggtcatcg     3120

aacaagtaag attatgaggt ttgttgataa aattaccaag tcaaaatatt tccaaaaagc     3180

aacagagaca gagtttatta aaaagaagat cgaagaagtc tccaacacac ccctgctgct     3240

cactgttgaa gtacaagaat gtagaggaac cttggcggtc aacattccac cacccccgac     3300

tgaccgagta tggtatggtt tccgaaagcc accacatgtg gagctgaaag ctcggccaaa     3360

acttggagag agagaagtga ctttagttca tgtgacagac tggatagaga agaaactgga     3420

gcaagagttt cagaaagttt ttgtcatgcc aaacatggat gatgtttata tcactataat     3480

gcactcagcc atggaccctc gctctacttc ctgcctcctg aaagacccac ctgtggaggc     3540

tgctgatcag ccatgatggg tgatgtcaga tgttccccat attgtgacat cgagctggat     3600

gtgtggggtt cttggccgcc atctgtactg tagcactggc ctctgtgcca cagctactgt     3660

ttcttaaagg actgcttctg ccctctgcct gccagtgccc attccactgt gaggtgtcat     3720

tccctgcatc tagtgacaac tgtctggatt gcctgctgca aagctttgat ttggcaaagg     3780

agaccatgga agaatcatgg tggatccaga agttatacgt gacccacacc atggctttta     3840

aaagtctacc catgtttgtg gcagcaaatg agcacagtaa gagcaaagct gaacaacttg     3900

cctcctctac tcctccaaag cttttcttca ggcagccggt gcacagtgga ctttttcact     3960

tctatacttt gtatgcggcc ttccacactt ccagagaatg tcagtgtgca atgtgtctgg     4020

agggtgggga gaggaattct gtgagccttt tcatttcggt gacagaagag atgggcagag     4080

caacttattt tccacattaa attgtgcatt tgggaagcaa gtagccatag tacacacaca     4140

acacgctatc agcttgggta aggacagtgg gatttatgtg aacatcaggc aaagccatga     4200

gatcaaacca tcccaagcct ttcaccaatg aggtacaacc acctgggggc tagctaatct     4260

tgaatgtttt cctgagacag gagcgtatgt gaaaacatca aacactgcac atgacaggat     4320

gggtcctctc atacagatgg gatggggtta gaaagccaga gccagttttt ccatctggcg     4380

tttcctgtgt cctccaggtt tatatgggaa tcgaaacagt ttgttaatct gattgggaga     4440

gttccatggg cagatttccc ttcctgaagg ccaaaacgga gaactgctct ctttaattat     4500

ttcaagagtc aagaccaaaa gtttgctcag catcacacta catctcaaaa ttaatgttgc     4560

caacttaatt ttgtgcattt gtgtcagaat gtttagttta caaggttggg ggctctcttt     4620

gcttcgagaa gtaaacctaa taccattttt ttattgttta aagctgcatt caacgtcaaa     4680

attaccttgg gtaacttttg ataacttaca tgtgtggaca aagctaatag tggtttttta     4740

aacagcacct tgcctgaaca tgactttaaa gaaattaata tattgaaaac atgtttgaac     4800

ccttatttta attgcaccat taaaacattt gacttaaatt gtttgaccat tccagttggt     4860

gtactgttct gatttttcgt tgtgtaggcc gatctgcctg tcagagtcca cgtgtcctgg     4920

tcactggtct ttataattgt tgtgcaataa ctaaaggcta aggactagat gcactatcgt     4980

gtaaagagat tacacatgac tgtaccatgt tgcacttaat caaatagtat gtggggattt     5040

aaaatcgctt gcattgtttc acaaaataaa tatctcaatg tcaaatacta aaaaaaaaaa     5100

aaaaa                                                                 5105


<210>  494
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Thr Ser Leu Tyr Gly Arg His Ala Glu Lys Thr Thr Asp Met Pro 
1               5                   10                  15      


Lys Pro Ser Ala Pro Lys Val His Val Gln Arg Ser Val Ser Arg Asp 
            20                  25                  30          


Thr Ile Ala Ile His Phe Ser Ala Ser Gly Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Glu Glu Phe Arg Glu Tyr Phe Glu Glu Gly Leu Asp Asp Gln Ser 
    50                  55                  60                  


Ile Val Thr Gly Leu Glu Ala Lys Glu Asp Leu Tyr Leu Glu Pro Gln 
65                  70                  75                  80  


Val Gly His Asp Pro Ala Gly Pro Ala Ala Ser Pro Val Leu Ala Asp 
                85                  90                  95      


Gly Leu Ser Val Ser Gln Ala Pro Ala Ile Leu Pro Val Ser Lys Asn 
            100                 105                 110         


Thr Val Lys Leu Leu Glu Ser Pro Val Pro Ala Ala Gln Val Leu Ser 
        115                 120                 125             


Thr Val Pro Leu Ala Val Ser Pro Gly Ser Ser Ser Ser Gly Pro Leu 
    130                 135                 140                 


Ala Ser Ser Pro Ser Val Ser Ser Leu Ser Glu Gln Lys Thr Ser Ser 
145                 150                 155                 160 


Ser Ser Pro Leu Ser Ser Pro Ser Lys Ser Pro Ile Leu Ser Ser Ser 
                165                 170                 175     


Ala Ser Thr Ser Thr Leu Ser Ser Ala Lys Pro Phe Met Ser Leu Val 
            180                 185                 190         


Lys Ser Leu Ser Thr Glu Val Glu Pro Lys Glu Ser Pro His Pro Ala 
        195                 200                 205             


Arg His Arg His Leu Met Lys Thr Leu Val Lys Ser Leu Ser Thr Asp 
    210                 215                 220                 


Thr Ser Arg Gln Glu Ser Asp Thr Val Ser Tyr Lys Pro Pro Asp Ser 
225                 230                 235                 240 


Lys Leu Asn Leu His Leu Phe Lys Gln Phe Thr Gln Pro Arg Asn Thr 
                245                 250                 255     


Gly Gly Asp Ser Lys Thr Ala Pro Ser Ser Pro Leu Thr Ser Pro Ser 
            260                 265                 270         


Asp Thr Arg Ser Phe Phe Lys Val Pro Glu Met Glu Ala Lys Ile Glu 
        275                 280                 285             


Asp Thr Lys Arg Arg Leu Ser Glu Val Ile Tyr Glu Pro Phe Gln Leu 
    290                 295                 300                 


Leu Ser Lys Ile Ile Gly Glu Glu Ser Gly Ser His Arg Pro Lys Ala 
305                 310                 315                 320 


Leu Ser Ser Ser Ala Ser Glu Leu Ser Asn Leu Ser Ser Leu Asn Gly 
                325                 330                 335     


His Leu Glu Ser Asn Asn Asn Tyr Ser Ile Lys Glu Glu Glu Cys Asp 
            340                 345                 350         


Ser Glu Gly Asp Gly Tyr Gly Ser Asp Ser Asn Ile Pro Arg Ser Asp 
        355                 360                 365             


His Pro Lys Ser Thr Gly Glu Pro Thr Arg Glu Ile Glu Leu Lys Ser 
    370                 375                 380                 


Ser Gln Gly Ser Ser Leu Lys Asp Leu Gly Leu Lys Thr Ser Ser Leu 
385                 390                 395                 400 


Val Leu Glu Lys Cys Ser Leu Ser Ala Leu Val Ser Lys Glu Asp Glu 
                405                 410                 415     


Glu Phe Cys Glu Leu Tyr Thr Glu Asp Phe Asp Leu Glu Thr Glu Gly 
            420                 425                 430         


Glu Ser Lys Val Asp Lys Leu Ser Asp Ile Pro Leu Lys Pro Glu Val 
        435                 440                 445             


Leu Ala Glu Asp Gly Val Val Leu Asp Ser Glu Asp Glu Val Asp Ser 
    450                 455                 460                 


Ala Val Gln His Pro Glu Leu Pro Val Lys Thr Leu Gly Phe Phe Ile 
465                 470                 475                 480 


Met Cys Val Tyr Val Tyr Leu Ile Leu Pro Leu Pro His Tyr Val Ser 
                485                 490                 495     


Gly Leu Phe Leu Gly Ile Gly Leu Gly Phe Met Thr Ala Val Cys Val 
            500                 505                 510         


Ile Trp Phe Phe Thr Pro Pro Ser Ala His Lys Tyr His Lys Leu His 
        515                 520                 525             


Lys Asn Leu Arg His Trp Asn Thr Arg Ser Leu Asp Ile Lys Glu Pro 
    530                 535                 540                 


Glu Ile Leu Lys Gly Trp Met Asn Glu Ile Tyr Asn Tyr Asp Pro Glu 
545                 550                 555                 560 


Thr Tyr His Ala Thr Leu Thr His Ser Val Phe Val Arg Leu Glu Gly 
                565                 570                 575     


Gly Thr Leu Arg Leu Ser Lys Pro Asn Lys Asn Ile Ser Arg Arg Ala 
            580                 585                 590         


Ser Tyr Asn Glu Pro Lys Pro Glu Val Thr Tyr Ile Ser Gln Lys Ile 
        595                 600                 605             


Tyr Asp Leu Ser Asp Ser Lys Ile Tyr Leu Val Pro Lys Thr Leu Ala 
    610                 615                 620                 


Arg Lys Arg Ile Trp Asn Lys Lys Tyr Pro Ile Cys Ile Glu Leu Gly 
625                 630                 635                 640 


Gln Gln Asp Asp Phe Met Ser Lys Ala Gln Thr Asp Lys Glu Thr Ser 
                645                 650                 655     


Glu Glu Lys Pro Pro Ala Glu Gly Ser Glu Asp Pro Lys Lys Pro Pro 
            660                 665                 670         


Arg Pro Gln Glu Gly Thr Arg Ser Ser Gln Arg Asp Gln Ile Leu Tyr 
        675                 680                 685             


Leu Phe Gly Arg Thr Gly Arg Glu Lys Glu Glu Trp Phe Arg Arg Phe 
    690                 695                 700                 


Ile Leu Ala Ser Lys Leu Lys Ser Glu Ile Lys Lys Ser Ser Gly Val 
705                 710                 715                 720 


Ser Gly Gly Lys Pro Ala Pro Val Phe Leu Ala Pro Gly Leu Leu Pro 
                725                 730                 735     


Ala His Ser Arg His Asn Ser Pro Ser Gly His Leu Thr His Ser Arg 
            740                 745                 750         


Ser Ser Ser Lys Gly Ser Val Glu Glu Ile Met Ser Gln Pro Lys Gln 
        755                 760                 765             


Lys Glu Leu Ala Gly Ser Val Arg Gln Lys Met Leu Leu Asp Tyr Ser 
    770                 775                 780                 


Val Tyr Met Gly Arg Cys Val Pro Gln Glu Ser Arg Ser Pro Gln Arg 
785                 790                 795                 800 


Ser Pro Leu Gln Ser Ala Glu Ser Ser Pro Thr Ala Gly Lys Lys Leu 
                805                 810                 815     


Pro Glu Val Pro Pro Ser Glu Glu Glu Glu Gln Glu Ala Trp Val Asn 
            820                 825                 830         


Ala Leu Leu Gly Arg Ile Phe Trp Asp Phe Leu Gly Glu Lys Tyr Trp 
        835                 840                 845             


Ser Asp Leu Val Ser Lys Lys Ile Gln Met Lys Leu Ser Lys Ile Lys 
    850                 855                 860                 


Leu Pro Tyr Phe Met Asn Glu Leu Thr Leu Thr Glu Leu Asp Met Gly 
865                 870                 875                 880 


Val Ala Val Pro Lys Ile Leu Gln Ala Phe Lys Pro Tyr Val Asp His 
                885                 890                 895     


Gln Gly Leu Trp Ile Asp Leu Glu Met Ser Tyr Asn Gly Ser Phe Leu 
            900                 905                 910         


Met Thr Leu Glu Thr Lys Met Asn Leu Thr Lys Leu Gly Lys Glu Pro 
        915                 920                 925             


Leu Val Glu Ala Leu Lys Val Gly Glu Ile Gly Lys Glu Gly Cys Arg 
    930                 935                 940                 


Pro Arg Ala Phe Cys Leu Ala Asp Ser Asp Glu Glu Ser Ser Ser Ala 
945                 950                 955                 960 


Gly Ser Ser Glu Glu Asp Asp Ala Pro Glu Pro Ser Gly Gly Asp Lys 
                965                 970                 975     


Gln Leu Leu Pro Gly Ala Glu Gly Tyr Val Gly Gly His Arg Thr Ser 
            980                 985                 990         


Lys Ile Met Arg Phe Val Asp Lys  Ile Thr Lys Ser Lys  Tyr Phe Gln 
        995                 1000                 1005             


Lys Ala  Thr Glu Thr Glu Phe  Ile Lys Lys Lys Ile  Glu Glu Val 
    1010                 1015                 1020             


Ser Asn  Thr Pro Leu Leu Leu  Thr Val Glu Val Gln  Glu Cys Arg 
    1025                 1030                 1035             


Gly Thr  Leu Ala Val Asn Ile  Pro Pro Pro Pro Thr  Asp Arg Val 
    1040                 1045                 1050             


Trp Tyr  Gly Phe Arg Lys Pro  Pro His Val Glu Leu  Lys Ala Arg 
    1055                 1060                 1065             


Pro Lys  Leu Gly Glu Arg Glu  Val Thr Leu Val His  Val Thr Asp 
    1070                 1075                 1080             


Trp Ile  Glu Lys Lys Leu Glu  Gln Glu Phe Gln Lys  Val Phe Val 
    1085                 1090                 1095             


Met Pro  Asn Met Asp Asp Val  Tyr Ile Thr Ile Met  His Ser Ala 
    1100                 1105                 1110             


Met Asp  Pro Arg Ser Thr Ser  Cys Leu Leu Lys Asp  Pro Pro Val 
    1115                 1120                 1125             


Glu Ala  Ala Asp Gln Pro 
    1130                 


<210>  495
<211>  1946
<212>  DNA
<213>  Homo sapiens

<400>  495
cttgatcata tgatgaaact aggtccacat tgtctccaca aaacaaattc atcaggcagc       60

tcctcctgag ggctaagcac ttgagacact cctggaactt tctgaaagtc tttgctgttg      120

gccctgagag acctcaacct ctcttcctga gctctataca gaaactttcc ttagagacac      180

cgtgggtcac cactgctgga tctgttgtac acttcctgtg tctccagcat gtcaaggcca      240

ctccagcctg taagtcattc ggatccaggg aggcttgcta atagccaaac ccaagaggcc      300

tgtgaggcta agccaccaga agccagacac cagtcacctc tgtcaactct ggaaaacgtc      360

cgggtgctga gaaatcttca aaacaagctc tacatgaaag aaacgtcttt gcacgagatg      420

aagacagagt tagagagtta caaagaaact aatgcccagc aggcgctaca gataatgtcc      480

ctgagagatg acgtcaagaa ccttcaagac cttattgact ctctaatgaa ggttaagatg      540

ttgaaaaaca cagaatctca gagtttcgga agacataact gggatctaac tgagcgagtt      600

atagacctag agaactgtct aagggagcac ctgacgggaa gagagcccgc atggagaaag      660

gcggagcttc tggagaaaag gcggtcctgc ccctgcagat tctctcctca catgaacctg      720

aaaggactgg aagattcctt ggatattttc cctgtgaagg tgagggacaa taataaagtc      780

tgcaactctg agagagacaa cattgtttac tcggaaggac caactgaggg gcaaaccacg      840

gtcgataaag gtcaacagga tttggtctac aaagaaaaac taacgtctga attggacaga      900

gctccgtatt cctgtagctg ggaccccacc catgagcatt cccaccacca ggacttcctc      960

ggtcagttgg ctacgctact gagtgacagc attggcccca tagtagccac ggaagaagca     1020

gtgaaagaga ggatccagga aatgggtgca aacgagcagc tgtggaaatt taaaactgaa     1080

gccctgcagc aggagattca gatgctcacc aagaggctcg agcagctgca ccacctttat     1140

gaagaggctg gtgaagggtc accccacact gaagaaaatt acatggagca gaaaagaccc     1200

ttgggatacc tggacgcaaa ggaaaactcc aggacccgga ctacccacac agataaacgc     1260

agcaaattca aacggttaga gatgttattg gatattgagc ggaattccaa gatggctgca     1320

gccccaaaaa tggaggagaa aattcagaga cttcagaagc agcttagtga tttgaaattg     1380

tcaaataaaa acatgaagac tcaactgaca agaataaatg tccttaaaga caaaacaatt     1440

gagcggctca ggcaatcagt aacaaaagtt gaaacagtga aagagaagac agcagccaaa     1500

acggacaact tgaaaatccc atctgatccc gtggagcagg cagcaagacc agaggagagg     1560

gcccaccaga cgccagcccg gagccttccc gagccttcta cagtcagaag catgctgaaa     1620

ggggtctcag gacgagagca agagctcgcc gactttcggg agaccattat gaagatgttg     1680

ggatttaaca tgaaaacagc ggacaaggat gtcattaatc agctgaagct tgtcgtccaa     1740

atttatgaag tctctaacaa atcaaagatg gattctcaca gtgagcctgg acccgccaag     1800

tgagcaagtt gtgcttattc atgctgctta ttcatgcagt tatatacggc tgtacctaca     1860

gctcccagag tatagctata ttgtgaataa aattggaaag tttcatctaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1946


<210>  496
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Ser Arg Pro Leu Gln Pro Val Ser His Ser Asp Pro Gly Arg Leu 
1               5                   10                  15      


Ala Asn Ser Gln Thr Gln Glu Ala Cys Glu Ala Lys Pro Pro Glu Ala 
            20                  25                  30          


Arg His Gln Ser Pro Leu Ser Thr Leu Glu Asn Val Arg Val Leu Arg 
        35                  40                  45              


Asn Leu Gln Asn Lys Leu Tyr Met Lys Glu Thr Ser Leu His Glu Met 
    50                  55                  60                  


Lys Thr Glu Leu Glu Ser Tyr Lys Glu Thr Asn Ala Gln Gln Ala Leu 
65                  70                  75                  80  


Gln Ile Met Ser Leu Arg Asp Asp Val Lys Asn Leu Gln Asp Leu Ile 
                85                  90                  95      


Asp Ser Leu Met Lys Val Lys Met Leu Lys Asn Thr Glu Ser Gln Ser 
            100                 105                 110         


Phe Gly Arg His Asn Trp Asp Leu Thr Glu Arg Val Ile Asp Leu Glu 
        115                 120                 125             


Asn Cys Leu Arg Glu His Leu Thr Gly Arg Glu Pro Ala Trp Arg Lys 
    130                 135                 140                 


Ala Glu Leu Leu Glu Lys Arg Arg Ser Cys Pro Cys Arg Phe Ser Pro 
145                 150                 155                 160 


His Met Asn Leu Lys Gly Leu Glu Asp Ser Leu Asp Ile Phe Pro Val 
                165                 170                 175     


Lys Val Arg Asp Asn Asn Lys Val Cys Asn Ser Glu Arg Asp Asn Ile 
            180                 185                 190         


Val Tyr Ser Glu Gly Pro Thr Glu Gly Gln Thr Thr Val Asp Lys Gly 
        195                 200                 205             


Gln Gln Asp Leu Val Tyr Lys Glu Lys Leu Thr Ser Glu Leu Asp Arg 
    210                 215                 220                 


Ala Pro Tyr Ser Cys Ser Trp Asp Pro Thr His Glu His Ser His His 
225                 230                 235                 240 


Gln Asp Phe Leu Gly Gln Leu Ala Thr Leu Leu Ser Asp Ser Ile Gly 
                245                 250                 255     


Pro Ile Val Ala Thr Glu Glu Ala Val Lys Glu Arg Ile Gln Glu Met 
            260                 265                 270         


Gly Ala Asn Glu Gln Leu Trp Lys Phe Lys Thr Glu Ala Leu Gln Gln 
        275                 280                 285             


Glu Ile Gln Met Leu Thr Lys Arg Leu Glu Gln Leu His His Leu Tyr 
    290                 295                 300                 


Glu Glu Ala Gly Glu Gly Ser Pro His Thr Glu Glu Asn Tyr Met Glu 
305                 310                 315                 320 


Gln Lys Arg Pro Leu Gly Tyr Leu Asp Ala Lys Glu Asn Ser Arg Thr 
                325                 330                 335     


Arg Thr Thr His Thr Asp Lys Arg Ser Lys Phe Lys Arg Leu Glu Met 
            340                 345                 350         


Leu Leu Asp Ile Glu Arg Asn Ser Lys Met Ala Ala Ala Pro Lys Met 
        355                 360                 365             


Glu Glu Lys Ile Gln Arg Leu Gln Lys Gln Leu Ser Asp Leu Lys Leu 
    370                 375                 380                 


Ser Asn Lys Asn Met Lys Thr Gln Leu Thr Arg Ile Asn Val Leu Lys 
385                 390                 395                 400 


Asp Lys Thr Ile Glu Arg Leu Arg Gln Ser Val Thr Lys Val Glu Thr 
                405                 410                 415     


Val Lys Glu Lys Thr Ala Ala Lys Thr Asp Asn Leu Lys Ile Pro Ser 
            420                 425                 430         


Asp Pro Val Glu Gln Ala Ala Arg Pro Glu Glu Arg Ala His Gln Thr 
        435                 440                 445             


Pro Ala Arg Ser Leu Pro Glu Pro Ser Thr Val Arg Ser Met Leu Lys 
    450                 455                 460                 


Gly Val Ser Gly Arg Glu Gln Glu Leu Ala Asp Phe Arg Glu Thr Ile 
465                 470                 475                 480 


Met Lys Met Leu Gly Phe Asn Met Lys Thr Ala Asp Lys Asp Val Ile 
                485                 490                 495     


Asn Gln Leu Lys Leu Val Val Gln Ile Tyr Glu Val Ser Asn Lys Ser 
            500                 505                 510         


Lys Met Asp Ser His Ser Glu Pro Gly Pro Ala Lys 
        515                 520                 


<210>  497
<211>  2197
<212>  DNA
<213>  Homo sapiens

<400>  497
attcttcctc ttgccacacc cacagggccc gcactaagag cctaactgaa atcccgcgag       60

gatcaaccga gctcgccgaa aggagggagg aacgtatccc ttctggaggc tgtctcaggg      120

ggcagaggga ccggaccgga agtgacgtga gcgggttccg gttgtctgga gcccagcggc      180

gggtgtgaga gtccgtaagg agcagcttcc aggatcctga gatccggagc agccggggtc      240

ggagcggctc ctcaagagtt actgatctat gaaatggcag agaatggaaa aaattgtgac      300

cagagacgtg tagcaatgaa caaggaacat cataatggaa atttcacaga cccctcttca      360

gtgaatgaaa agaagaggag ggagcgggaa gaaaggcaga atattgtcct gtggagacag      420

ccgctcatta ccttgcagta tttttctctg gaaatccttg taatcttgaa ggaatggacc      480

tcaaaattat ggcatcgtca aagcattgtg gtgtcttttt tactgctgct tgctgtgctt      540

atagctacgt attatgttga aggagtgcat caacagtatg tgcaacgtat agagaaacag      600

tttcttttgt atgcctactg gataggctta ggaattttgt cttctgttgg gcttggaaca      660

gggctgcaca cctttctgct ttatctgggt ccacatatag cctcagttac attagctgct      720

tatgaatgca attcagttaa ttttcccgaa ccaccctatc ctgatcagat tatttgtcca      780

gatgaagagg gcactgaagg aaccatttct ttgtggagta tcatctcaaa agttaggatt      840

gaagcctgca tgtggggtat cggtacagca atcggagagc tgcctccata tttcatggcc      900

agagcagctc gcctctcagg tgctgaacca gatgatgaag agtatcagga atttgaagag      960

atgctggaac atgcagagtc tgcacaagac tttgcctccc gggccaaact ggcagttcaa     1020

aaactagtac agaaagttgg attttttgga attttggcct gtgcttcaat tccaaatcct     1080

ttatttgatc tggctggaat aacgtgtgga cactttctgg tacctttttg gaccttcttt     1140

ggtgcaaccc taattggaaa agcaataata aaaatgcata tccagaaaat ttttgttata     1200

ataacattca gcaagcacat agtggagcaa atggtggctt tcattggtgc tgtccccggc     1260

ataggtccat ctctgcagaa gccatttcag gagtacctgg aggctcaacg gcagaagctt     1320

caccacaaaa gcgaaatggg cacaccacag ggagaaaact ggttgtcctg gatgtttgaa     1380

aagttggtcg ttgtcatggt gtgttacttc atcctatcta tcattaactc catggcacaa     1440

agttatgcca aacgaatcca gcagcggttg aactcagagg agaaaactaa ataagtagag     1500

aaagttttaa actgcagaaa ttggagtgga tgggttctgc cttaaattgg gaggactcca     1560

agccgggaag gaaaattccc ttttccaacc tgtatcaatt tttacaactt ttttcctgaa     1620

agcagtttag tccatacttt gcactgacat actttttcct tctgtgctaa ggtaaggtat     1680

ccaccctcga tgcaatccac cttgtgtttt cttagggtgg aatgtgatgt tcagcagcaa     1740

acttgcaaca gactggcctt ctgtttgtta ctttcaaaag gcccacatga tacaattaga     1800

gaattcccac cgcacaaaaa aagttcctaa gtatgttaaa tatgtcaagc tttttaggct     1860

tgtcacaaat gattgctttg ttttcctaag tcatcaaaat gtatataaat tatctagatt     1920

ggataacagt cttgcatgtt tatcatgtta caatttaata ttccatcctg cccaaccctt     1980

cctctcccat cctcaaaaaa gggccatttt atgatgcatt gcacaccctc tggggaaatt     2040

gatctttaaa ttttgagaca gtataaggaa aatctggttg gtgtcttaca agtgagctga     2100

caccattttt tattctgtgt atttagaatg aagtcttgaa aaaaacttta taaagacatc     2160

tttaatcatt ccaaaaaaaa aaaaaaaaaa aaaaaaa                              2197


<210>  498
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Ala Glu Asn Gly Lys Asn Cys Asp Gln Arg Arg Val Ala Met Asn 
1               5                   10                  15      


Lys Glu His His Asn Gly Asn Phe Thr Asp Pro Ser Ser Val Asn Glu 
            20                  25                  30          


Lys Lys Arg Arg Glu Arg Glu Glu Arg Gln Asn Ile Val Leu Trp Arg 
        35                  40                  45              


Gln Pro Leu Ile Thr Leu Gln Tyr Phe Ser Leu Glu Ile Leu Val Ile 
    50                  55                  60                  


Leu Lys Glu Trp Thr Ser Lys Leu Trp His Arg Gln Ser Ile Val Val 
65                  70                  75                  80  


Ser Phe Leu Leu Leu Leu Ala Val Leu Ile Ala Thr Tyr Tyr Val Glu 
                85                  90                  95      


Gly Val His Gln Gln Tyr Val Gln Arg Ile Glu Lys Gln Phe Leu Leu 
            100                 105                 110         


Tyr Ala Tyr Trp Ile Gly Leu Gly Ile Leu Ser Ser Val Gly Leu Gly 
        115                 120                 125             


Thr Gly Leu His Thr Phe Leu Leu Tyr Leu Gly Pro His Ile Ala Ser 
    130                 135                 140                 


Val Thr Leu Ala Ala Tyr Glu Cys Asn Ser Val Asn Phe Pro Glu Pro 
145                 150                 155                 160 


Pro Tyr Pro Asp Gln Ile Ile Cys Pro Asp Glu Glu Gly Thr Glu Gly 
                165                 170                 175     


Thr Ile Ser Leu Trp Ser Ile Ile Ser Lys Val Arg Ile Glu Ala Cys 
            180                 185                 190         


Met Trp Gly Ile Gly Thr Ala Ile Gly Glu Leu Pro Pro Tyr Phe Met 
        195                 200                 205             


Ala Arg Ala Ala Arg Leu Ser Gly Ala Glu Pro Asp Asp Glu Glu Tyr 
    210                 215                 220                 


Gln Glu Phe Glu Glu Met Leu Glu His Ala Glu Ser Ala Gln Asp Phe 
225                 230                 235                 240 


Ala Ser Arg Ala Lys Leu Ala Val Gln Lys Leu Val Gln Lys Val Gly 
                245                 250                 255     


Phe Phe Gly Ile Leu Ala Cys Ala Ser Ile Pro Asn Pro Leu Phe Asp 
            260                 265                 270         


Leu Ala Gly Ile Thr Cys Gly His Phe Leu Val Pro Phe Trp Thr Phe 
        275                 280                 285             


Phe Gly Ala Thr Leu Ile Gly Lys Ala Ile Ile Lys Met His Ile Gln 
    290                 295                 300                 


Lys Ile Phe Val Ile Ile Thr Phe Ser Lys His Ile Val Glu Gln Met 
305                 310                 315                 320 


Val Ala Phe Ile Gly Ala Val Pro Gly Ile Gly Pro Ser Leu Gln Lys 
                325                 330                 335     


Pro Phe Gln Glu Tyr Leu Glu Ala Gln Arg Gln Lys Leu His His Lys 
            340                 345                 350         


Ser Glu Met Gly Thr Pro Gln Gly Glu Asn Trp Leu Ser Trp Met Phe 
        355                 360                 365             


Glu Lys Leu Val Val Val Met Val Cys Tyr Phe Ile Leu Ser Ile Ile 
    370                 375                 380                 


Asn Ser Met Ala Gln Ser Tyr Ala Lys Arg Ile Gln Gln Arg Leu Asn 
385                 390                 395                 400 


Ser Glu Glu Lys Thr Lys 
                405     


<210>  499
<211>  8559
<212>  DNA
<213>  Homo sapiens

<400>  499
gaatgttccc gccgcgggct ccgccccccg gccaatcgga ccggcgctcg gtgaagccca       60

gattctcttt gttccgcagc catttcaggc cccggacagg aggcagtgcc gcttcggccg      120

aaggcccgag cgcccgaggc gtctgggatg gtgtgggacc ggcaaaccaa gatggagtat      180

gagtggaaac ctgacgagca agggcttcag caaatcctgc agctgttgaa ggagtcccag      240

tccccagaca ccaccatcca gagaaccgtg caacaaaaac tggaacaact taatcagtat      300

ccagacttta acaactactt gatttttgtt cttacaaaat taaaatctga agatgaaccc      360

acaagatcat tgagtggtct tatcttgaag aataatgtga aagcacactt tcagaacttc      420

ccaaatggtg taacagactt tattaaaagt gaatgtttaa ataatattgg tgactcctct      480

cctctgatta gagccactgt tggtattttg atcacaacta tagcctccaa gggagaattg      540

cagaattggc ctgacctctt accaaaactc tgtagcctgt tggattctga agattataat      600

acctgtgagg gagcatttgg tgcccttcag aagatttgtg aagattctgc tgagatttta      660

gacagtgatg ttttagatcg tcctctcaac atcatgattc ccaaattttt acagttcttc      720

aagcatagta gtccaaaaat aaggtctcac gctgttgcat gtgtcaatca gtttatcatc      780

agtaggactc aagctctaat gttgcacatt gattctttta ttgagaatct ctttgcatta      840

gctggtgatg aagaaccaga ggtacggaaa aatgtgtgcc gagcacttgt gatgttgctc      900

gaagttcgaa tggatcgcct gcttcctcac atgcataata tagttgagta catgctacag      960

aggactcaag atcaagatga aaatgtggct ttagaagcct gtgaattttg gctaacttta     1020

gctgaacagc caatatgcaa agatgtactc gtaaggcatc ttcctaagtt gattcctgtg     1080

ttagtgaatg gcatgaagta ctcagacata gatattatcc tacttaaggg tgatgttgaa     1140

gaagacgaaa cgattcctga tagtgaacag gatatacggc cacgttttca ccgatcgagg     1200

acggtggctc agcagcatga tgaagatgga attgaagagg aagatgatga tgatgatgaa     1260

attgatgatg atgatacaat ttctgactgg aatctaagaa aatgttctgc tgctgccctg     1320

gatgttcttg caaatgtgta tcgtgatgaa ctgctgccac atattttgcc ccttttgaaa     1380

gaattacttt ttcatcatga atgggttgtt aaagaatcag gcattttggt tttaggagca     1440

attgctgaag gttgcatgca gggcatgatt ccatacttgc ctgagcttat tcctcacctt     1500

attcagtgcc tctctgataa aaaggctctt gtgcgttcca taacatgctg gactcttagc     1560

cgctatgcac actgggtggt cagccagccg ccagacacgt acctgaagcc attaatgaca     1620

gaattgctaa agcgcatcct ggacagcaac aagagagtac aagaagctgc ctgcagtgcc     1680

tttgctaccc tagaagagga ggcttgtaca gaacttgttc cttaccttgc ttatatactt     1740

gataccctgg tctttgcatt tagtaaatac cagcataaga acctgctcat tctttacgat     1800

gccataggaa cattagcaga ttcagtagga catcatttaa acaaaccaga atatattcag     1860

atgctaatgc ctccactgat ccagaaatgg aacatgttaa aggatgaaga taaagatctc     1920

ttccctttac ttgagtgcct atcttcagtt gccacagcac tgcagtctgg attccttccg     1980

tactgtgaac ctgtgtatca gcgttgtgta aacctagtac agaagactct tgcacaagcc     2040

atgctaaaca atgctcaacc agatcaatat gaagctccag ataaagattt tatgatagtg     2100

gctcttgatt tactgagtgg cctggctgaa ggacttggag gcaacattga acagctggta     2160

gcccgaagta acatcctgac actaatgtat cagtgcatgc aggataaaat gccagaagtt     2220

cgacagagtt cttttgccct gttaggtgac ctcacaaaag cttgctttca gcatgttaag     2280

ccttgtatag ctgatttcat gccaatattg ggaaccaacc taaatccaga attcatttca     2340

gtctgcaaca atgccacatg ggcaattgga gaaatctcca ttcaaatggg tatagagatg     2400

cagccttata ttcctatggt gttgcaccag cttgtagaaa tcattaacag acccaacaca     2460

ccaaagacgt tgttagagaa tacagcaata acaattggtc gtcttggtta cgtttgtcct     2520

caagaggtgg cccccatgct acagcagttt ataagaccct ggtgcacctc tctgagaaac     2580

ataagagaca atgaggaaaa ggattcagca ttccgtggaa tttgtaccat gatcagtgtg     2640

aatcccagtg gcgtaatcca agattttata tttttttgtg atgccgttgc atcatggatt     2700

aacccaaaag atgatctcag agacatgttc tgtaagatcc ttcatggatt taaaaatcaa     2760

gttggcgatg aaaattggag gcgtttctct gaccagtttc ctcttccctt aaaagagcgt     2820

cttgcagctt tttatggtgt ttaatctaat acacttaagc tgcagtccca aaattagggg     2880

tccttcagtc ttggagacta taagggagcc tctgcaccca gggaaaatgt taccctttac     2940

aggggggaag ggtaaaccag tagggaatac agtacaatcc caaccctact gggaggggcg     3000

ggagggaggt gttgccgtca ctgtattaag tcgatgttgg gaaacgtttt aacatctgga     3060

gcctttgtgg gtggaaatat gtctccagtt acaactccgc agtggatgtg aagaagcaaa     3120

aaaaaaaaaa tctattcagt ctactcacaa aacagtacat tgtggaatat tatggggaat     3180

tgtaccaaaa caagaaccat ataaatgatg cctagggaca agaaagagga acaattctat     3240

agcgcacaat aaaggaaacc taagaatggg agttacaaat agtaaagaag cttttttttt     3300

ttttttaatt taaagttttt ttatgtaagt tttcccacat gatggggcct tgttttgcat     3360

gttgatgaag aactacacaa agaaaactaa tatagttaaa agtcagcttg ccttcccgta     3420

gtagaagcag gttcttggaa gttacaattt aaggtacccc aaaaaagttg gaaataaaac     3480

aaaacaaaca taaacaatga agcaccctgt gaaatgccaa atgagtcact ccttttacct     3540

tttttggggt gggcagggag ggaggaataa atggggttgg gcatatcaaa ctaaagatga     3600

catcttaatt ttgcattgaa cattaatgta gcggatataa tttgatgatt atacttcatt     3660

agatttaatt tctaggccaa gatgttactt tttaaagtgc agtttaaggt tcaggcatgc     3720

attctggctc atagtggttg aaagtaattt aaattagtgg gaaagtagca tgcttgcatc     3780

acatagagtg agattggtat tcatttacct atgttgcgcc agtttgtgtt gcagtttacc     3840

aattcaatat agccctgcat ttaaagttcc tttttaagat ttgtggattt tatttttatt     3900

aagaacatag atatataaag tactgtagtt tacaggtagg ccttgaaata tcttttttag     3960

gatctgttag gaataagatt gatattgtat tgtgtgtaac ctgcacaatg tggaaagctg     4020

atatacctgt gcaaaatctt tgcctctgtg ctgtcagtgt gatgtgcttt ctgcatggtt     4080

atatactact agtgatttta tcaaaacttc taaaatttaa attacgtggt aaaagatctg     4140

taaaaggctg cataaatgtt agttggcaca taaagacaat tgtagaagtt gaaaaatgat     4200

tgctatattt caatgtttat tcccactcaa catactgcct tctaagcttc cctttttttg     4260

ttcaaagcat gatcttaaag atatgtttaa gttaatggat gtaatgcagg gttcctacac     4320

tgtattttgg cgcatgttgg tggccctctg tgccctagat atatgcacac agggtgcaag     4380

ttaaaagcta cagagtgaaa gttggtttgg atcctcttca tttcatttgt ttagcttttc     4440

tgttattttt ctctacttac atgtattcct gtgaataaat ccttgttaag ttaacccttt     4500

acttttcctt ccatgtgtat tttcttatat actgtgaatg tgaaaaccta actggtacac     4560

ttgatcttgt gttcatatga aagtgcaagt ctttattaat ttggattgcc tgaacagtgt     4620

atcccatgat gatgaaggaa aatggagaga tttttctttt taactctgct ggtcagagat     4680

gaagccacgc ctttccattt ttcaatgctg catatttaat ctgcaacaaa aatgttaagc     4740

cataacagcc tttttatatt ttagtttgtc acctttgcat tgcagaataa atactgaata     4800

accattttta taagcagttg ctcctctttg catggttcta ttctctaaaa gtgttgaatg     4860

atacagccat tgcactgaag tttgagctgt gtgcgtgtga atttatactg tttcaaaaat     4920

ttcaaatgca tggtagcatg tagaaaggtt tttgttacta tgtgtgtgtg tgtgttttgt     4980

tttgttttgt tctgtttttt aacgttcttt cacctttcct ctactttggc tttgcaaatt     5040

tcagtctgta gagcctgaaa ttaaattatt ttatagtgcc tgatattttt aatattataa     5100

gttggattca aagggtatac agcattttgt tttctagtac cattgcttca ctgggagctc     5160

aaaatttgcc tccctgttag tctttaataa ctgagtagag tagctttttt attcttagat     5220

tatagtgata ttctgtagtg cttcaaatac ttagaattct aatatgagag atagtttaat     5280

attctggaat agagagtatt ttaaattgaa atgaccaaat tcgatttaaa acaaacacat     5340

aacaatcttc agtaaagtta tttgaacctg tggttgacaa ttctgtattg actaaaggca     5400

atattgtcac ctgtctcatt aaaaattagt ttccagttag gcagatgaat aacactatta     5460

aaaatgcacc cagttttgta gtcacttgac tttttttttt tatttaaatg aaatttaatt     5520

tgaaaataga aaataaaatt aggtaaatat gactggcaac ctgaatttga gttgggattc     5580

tttgtgtatt tttccccctt gaggttattg tttcttccta atttatattt cagatacata     5640

gtgtagaaca ggaatttgca gaagccattt aagttatctt ttgaggtaag ctctgattta     5700

gcatttattc tgataaaatc taatacatca tgggatatat ataaagcaac ttaattcttg     5760

tggtgtagtc ttaatagttt tgaatgttga ctgaatgtct ataaaattgt gagtttgtct     5820

ttgttacatt ccagtgtttc tgcctcttgg catgcttaaa gcacggctta cttcatctgc     5880

tccttacaca ctaaaatgct gttagtgtgc tcaactacag aaatagccgc tgctaagtga     5940

tgtagatttt ctacttgaat atttttatgt tgtaggaacc tcaggaggtc agtgtttact     6000

gttttatata tgccttcttt ttcctgtttg agcttctctc tttgaaggat tctaacagaa     6060

caaagctgct gatcaaccta agttggaaac agaaagtgta attaatataa cttaaatgca     6120

tgtttggcag ttccatgtta cagtccatta gcgagtgaac ttagtgccac aggtattcat     6180

ttattcagga aagaattttg ctttttgtat tgtctaatct cttcaatgac ttcatactgt     6240

gtaaaaaaaa atcacttttt aatatttttt ggttggttat ttcccaaata atcaacatgt     6300

aaataatctt ttaagagcca gttctgatgc tttacattat tgctacttga ttttgttatg     6360

caagttagat ttcagaagaa tagattttaa aacacttaac caagccatta catcttaaaa     6420

acaaaacaag tagcatacat tttgtaatta acattgataa acactgtgat ttttttggtt     6480

aagacttttt cattgatctg aattgcttaa attgcatata ttgtaaaata ggatcagatg     6540

tatattttaa actaatttca atggattttc ctcttgaaat gctttgtcta ctcagttata     6600

aaatattcag atacaagttt tatctcaggt gaatactctt gtattgtttt tgctttggtg     6660

acatgcttat aaagggtcat cctagttaca ttctttgttt tttaagtgta tttcattgag     6720

aatctttcca tttagtctga tttttttcct aatattctag caggctgggg tggtataaag     6780

ccctcctgac aagccttttg cctacaggtt tacctgaaaa tgagctacat atggtcgtca     6840

ttttcttcaa actctcaaaa taggaaagtg gaaatttttc tcccctatat aaaattattc     6900

tgcctagcag aaatgccaga aataaattaa ttgcatctta gtctaaattt aagtcctttg     6960

ccatgaggaa aaagtggttt tttgcttcat atggtaaatc tatattattc atattgaatg     7020

tattaacaga taatggtgca aaagcattct tcccagggga agagtgtatc atgcataact     7080

gcaatttaag tccttccttt gataatactt caaaacatac acagctttgc ttactgaatt     7140

atttttgcaa ataatacaag gaggggaaac taacttgcta ctagtgttgt taatgaagta     7200

taggccttgg aacatttaag aaaactggtc ttcagatagt taagggcttg ggataattta     7260

agtgaaaagt gagatcagta atgagctgtg ttgttaacaa tattatctgg taataatacc     7320

atgcaatata gcgttgtata ccaacttagt gcattttata ctgtattaaa tatggagata     7380

cttctaatgc ctctctaaaa ttaaatttta cataaaagtt agttttattc acctttaggc     7440

tttccaagtg aattgtgact aattttttca atcttacata gatctttcac ccattagcat     7500

tacttacgta gataattctt tatgcctagt tattatacat attaattttt aaggtataca     7560

tttaaattac acaattgttc attgtggttt gtatcccaga atgtgttgtg ttttttaaaa     7620

gatgcataat agctgaatgt atgcatgact ttgaaagaag ttaaaatggt gatttttttt     7680

cacctcttgt acattttaaa accaggccaa atctatttgc caagcagtgt atcactaata     7740

agaaaagcag tttttccttt tattgcagtt tttgtttatc tgccatagaa tttccttata     7800

ctgtggcttg gtattattca agattagcta tttcgctggt attacatctt tttaaaagcc     7860

tattataaca tggttagcct ataaggcagt gttggtcccc ttctaatatt ggcctcataa     7920

aggggttcca ctgtactttc cgcatattac tgtgttgttg ttttcctttg tggatatata     7980

agcaaattga gcttgggtga tttttatgga gacaataatt agacaatact gtataattag     8040

ttttacttaa tagattatca tcttgtgaga agagatgttt aaacgtggta aatcacttca     8100

tattacaaaa cagttttaca cttaatatgt taacattggg tgcaataatt tagtagcatt     8160

agctttagtt acaaatataa ctggatcttt ctgctgacaa cttaggttgt atgagttatg     8220

cttaaaagct ttaaatctga tgtttcctgt acctgccaca ctatgttaga atgtgtcctt     8280

caaacatatc ctcctgcaac ttctcaaact gtactaaatt gatatttctt gaagtctaac     8340

tctgtgctaa cagatctcca ttttaaatag aatacggttt taatttttga taagctgctg     8400

aattttaaag agagtttttt ggggccacca aatattttgg atcatgcaga gaatatatat     8460

tgtactgtag taattttgta tttacatttg tatgatgtga cataatagat gtgaatgtta     8520

atcactgctt gactatgtta ataaagttgt ttaactata                            8559


<210>  500
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Val Trp Asp Arg Gln Thr Lys Met Glu Tyr Glu Trp Lys Pro Asp 
1               5                   10                  15      


Glu Gln Gly Leu Gln Gln Ile Leu Gln Leu Leu Lys Glu Ser Gln Ser 
            20                  25                  30          


Pro Asp Thr Thr Ile Gln Arg Thr Val Gln Gln Lys Leu Glu Gln Leu 
        35                  40                  45              


Asn Gln Tyr Pro Asp Phe Asn Asn Tyr Leu Ile Phe Val Leu Thr Lys 
    50                  55                  60                  


Leu Lys Ser Glu Asp Glu Pro Thr Arg Ser Leu Ser Gly Leu Ile Leu 
65                  70                  75                  80  


Lys Asn Asn Val Lys Ala His Phe Gln Asn Phe Pro Asn Gly Val Thr 
                85                  90                  95      


Asp Phe Ile Lys Ser Glu Cys Leu Asn Asn Ile Gly Asp Ser Ser Pro 
            100                 105                 110         


Leu Ile Arg Ala Thr Val Gly Ile Leu Ile Thr Thr Ile Ala Ser Lys 
        115                 120                 125             


Gly Glu Leu Gln Asn Trp Pro Asp Leu Leu Pro Lys Leu Cys Ser Leu 
    130                 135                 140                 


Leu Asp Ser Glu Asp Tyr Asn Thr Cys Glu Gly Ala Phe Gly Ala Leu 
145                 150                 155                 160 


Gln Lys Ile Cys Glu Asp Ser Ala Glu Ile Leu Asp Ser Asp Val Leu 
                165                 170                 175     


Asp Arg Pro Leu Asn Ile Met Ile Pro Lys Phe Leu Gln Phe Phe Lys 
            180                 185                 190         


His Ser Ser Pro Lys Ile Arg Ser His Ala Val Ala Cys Val Asn Gln 
        195                 200                 205             


Phe Ile Ile Ser Arg Thr Gln Ala Leu Met Leu His Ile Asp Ser Phe 
    210                 215                 220                 


Ile Glu Asn Leu Phe Ala Leu Ala Gly Asp Glu Glu Pro Glu Val Arg 
225                 230                 235                 240 


Lys Asn Val Cys Arg Ala Leu Val Met Leu Leu Glu Val Arg Met Asp 
                245                 250                 255     


Arg Leu Leu Pro His Met His Asn Ile Val Glu Tyr Met Leu Gln Arg 
            260                 265                 270         


Thr Gln Asp Gln Asp Glu Asn Val Ala Leu Glu Ala Cys Glu Phe Trp 
        275                 280                 285             


Leu Thr Leu Ala Glu Gln Pro Ile Cys Lys Asp Val Leu Val Arg His 
    290                 295                 300                 


Leu Pro Lys Leu Ile Pro Val Leu Val Asn Gly Met Lys Tyr Ser Asp 
305                 310                 315                 320 


Ile Asp Ile Ile Leu Leu Lys Gly Asp Val Glu Glu Asp Glu Thr Ile 
                325                 330                 335     


Pro Asp Ser Glu Gln Asp Ile Arg Pro Arg Phe His Arg Ser Arg Thr 
            340                 345                 350         


Val Ala Gln Gln His Asp Glu Asp Gly Ile Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Asp Asp Glu Ile Asp Asp Asp Asp Thr Ile Ser Asp Trp Asn Leu Arg 
    370                 375                 380                 


Lys Cys Ser Ala Ala Ala Leu Asp Val Leu Ala Asn Val Tyr Arg Asp 
385                 390                 395                 400 


Glu Leu Leu Pro His Ile Leu Pro Leu Leu Lys Glu Leu Leu Phe His 
                405                 410                 415     


His Glu Trp Val Val Lys Glu Ser Gly Ile Leu Val Leu Gly Ala Ile 
            420                 425                 430         


Ala Glu Gly Cys Met Gln Gly Met Ile Pro Tyr Leu Pro Glu Leu Ile 
        435                 440                 445             


Pro His Leu Ile Gln Cys Leu Ser Asp Lys Lys Ala Leu Val Arg Ser 
    450                 455                 460                 


Ile Thr Cys Trp Thr Leu Ser Arg Tyr Ala His Trp Val Val Ser Gln 
465                 470                 475                 480 


Pro Pro Asp Thr Tyr Leu Lys Pro Leu Met Thr Glu Leu Leu Lys Arg 
                485                 490                 495     


Ile Leu Asp Ser Asn Lys Arg Val Gln Glu Ala Ala Cys Ser Ala Phe 
            500                 505                 510         


Ala Thr Leu Glu Glu Glu Ala Cys Thr Glu Leu Val Pro Tyr Leu Ala 
        515                 520                 525             


Tyr Ile Leu Asp Thr Leu Val Phe Ala Phe Ser Lys Tyr Gln His Lys 
    530                 535                 540                 


Asn Leu Leu Ile Leu Tyr Asp Ala Ile Gly Thr Leu Ala Asp Ser Val 
545                 550                 555                 560 


Gly His His Leu Asn Lys Pro Glu Tyr Ile Gln Met Leu Met Pro Pro 
                565                 570                 575     


Leu Ile Gln Lys Trp Asn Met Leu Lys Asp Glu Asp Lys Asp Leu Phe 
            580                 585                 590         


Pro Leu Leu Glu Cys Leu Ser Ser Val Ala Thr Ala Leu Gln Ser Gly 
        595                 600                 605             


Phe Leu Pro Tyr Cys Glu Pro Val Tyr Gln Arg Cys Val Asn Leu Val 
    610                 615                 620                 


Gln Lys Thr Leu Ala Gln Ala Met Leu Asn Asn Ala Gln Pro Asp Gln 
625                 630                 635                 640 


Tyr Glu Ala Pro Asp Lys Asp Phe Met Ile Val Ala Leu Asp Leu Leu 
                645                 650                 655     


Ser Gly Leu Ala Glu Gly Leu Gly Gly Asn Ile Glu Gln Leu Val Ala 
            660                 665                 670         


Arg Ser Asn Ile Leu Thr Leu Met Tyr Gln Cys Met Gln Asp Lys Met 
        675                 680                 685             


Pro Glu Val Arg Gln Ser Ser Phe Ala Leu Leu Gly Asp Leu Thr Lys 
    690                 695                 700                 


Ala Cys Phe Gln His Val Lys Pro Cys Ile Ala Asp Phe Met Pro Ile 
705                 710                 715                 720 


Leu Gly Thr Asn Leu Asn Pro Glu Phe Ile Ser Val Cys Asn Asn Ala 
                725                 730                 735     


Thr Trp Ala Ile Gly Glu Ile Ser Ile Gln Met Gly Ile Glu Met Gln 
            740                 745                 750         


Pro Tyr Ile Pro Met Val Leu His Gln Leu Val Glu Ile Ile Asn Arg 
        755                 760                 765             


Pro Asn Thr Pro Lys Thr Leu Leu Glu Asn Thr Ala Ile Thr Ile Gly 
    770                 775                 780                 


Arg Leu Gly Tyr Val Cys Pro Gln Glu Val Ala Pro Met Leu Gln Gln 
785                 790                 795                 800 


Phe Ile Arg Pro Trp Cys Thr Ser Leu Arg Asn Ile Arg Asp Asn Glu 
                805                 810                 815     


Glu Lys Asp Ser Ala Phe Arg Gly Ile Cys Thr Met Ile Ser Val Asn 
            820                 825                 830         


Pro Ser Gly Val Ile Gln Asp Phe Ile Phe Phe Cys Asp Ala Val Ala 
        835                 840                 845             


Ser Trp Ile Asn Pro Lys Asp Asp Leu Arg Asp Met Phe Cys Lys Ile 
    850                 855                 860                 


Leu His Gly Phe Lys Asn Gln Val Gly Asp Glu Asn Trp Arg Arg Phe 
865                 870                 875                 880 


Ser Asp Gln Phe Pro Leu Pro Leu Lys Glu Arg Leu Ala Ala Phe Tyr 
                885                 890                 895     


Gly Val 
        


<210>  501
<211>  8546
<212>  DNA
<213>  Homo sapiens

<400>  501
agattgcaaa ttcgcggtga ctcagtctgg tcggctcctt gcgctcggcg gccgcggcgg       60

cagcagcagc agacgctggc ggccgggctg ccaggagcag ttccgccggg tttcactgtc      120

cgtgacttcc ttcggggcac ctcaggcagc aaaccaagat ggagtatgag tggaaacctg      180

acgagcaagg gcttcagcaa atcctgcagc tgttgaagga gtcccagtcc ccagacacca      240

ccatccagag aaccgtgcaa caaaaactgg aacaacttaa tcagtatcca gactttaaca      300

actacttgat ttttgttctt acaaaattaa aatctgaaga tgaacccaca agatcattga      360

gtggtcttat cttgaagaat aatgtgaaag cacactttca gaacttccca aatggtgtaa      420

cagactttat taaaagtgaa tgtttaaata atattggtga ctcctctcct ctgattagag      480

ccactgttgg tattttgatc acaactatag cctccaaggg agaattgcag aattggcctg      540

acctcttacc aaaactctgt agcctgttgg attctgaaga ttataatacc tgtgagggag      600

catttggtgc ccttcagaag atttgtgaag attctgctga gattttagac agtgatgttt      660

tagatcgtcc tctcaacatc atgattccca aatttttaca gttcttcaag catagtagtc      720

caaaaataag gtctcacgct gttgcatgtg tcaatcagtt tatcatcagt aggactcaag      780

ctctaatgtt gcacattgat tcttttattg agaatctctt tgcattagct ggtgatgaag      840

aaccagaggt acggaaaaat gtgtgccgag cacttgtgat gttgctcgaa gttcgaatgg      900

atcgcctgct tcctcacatg cataatatag ttgagtacat gctacagagg actcaagatc      960

aagatgaaaa tgtggcttta gaagcctgtg aattttggct aactttagct gaacagccaa     1020

tatgcaaaga tgtactcgta aggcatcttc ctaagttgat tcctgtgtta gtgaatggca     1080

tgaagtactc agacatagat attatcctac ttaagggtga tgttgaagaa gacgaaacga     1140

ttcctgatag tgaacaggat atacggccac gttttcaccg atcgaggacg gtggctcagc     1200

agcatgatga agatggaatt gaagaggaag atgatgatga tgatgaaatt gatgatgatg     1260

atacaatttc tgactggaat ctaagaaaat gttctgctgc tgccctggat gttcttgcaa     1320

atgtgtatcg tgatgaactg ctgccacata ttttgcccct tttgaaagaa ttactttttc     1380

atcatgaatg ggttgttaaa gaatcaggca ttttggtttt aggagcaatt gctgaaggtt     1440

gcatgcaggg catgattcca tacttgcctg agcttattcc tcaccttatt cagtgcctct     1500

ctgataaaaa ggctcttgtg cgttccataa catgctggac tcttagccgc tatgcacact     1560

gggtggtcag ccagccgcca gacacgtacc tgaagccatt aatgacagaa ttgctaaagc     1620

gcatcctgga cagcaacaag agagtacaag aagctgcctg cagtgccttt gctaccctag     1680

aagaggaggc ttgtacagaa cttgttcctt accttgctta tatacttgat accctggtct     1740

ttgcatttag taaataccag cataagaacc tgctcattct ttacgatgcc ataggaacat     1800

tagcagattc agtaggacat catttaaaca aaccagaata tattcagatg ctaatgcctc     1860

cactgatcca gaaatggaac atgttaaagg atgaagataa agatctcttc cctttacttg     1920

agtgcctatc ttcagttgcc acagcactgc agtctggatt ccttccgtac tgtgaacctg     1980

tgtatcagcg ttgtgtaaac ctagtacaga agactcttgc acaagccatg ctaaacaatg     2040

ctcaaccaga tcaatatgaa gctccagata aagattttat gatagtggct cttgatttac     2100

tgagtggcct ggctgaagga cttggaggca acattgaaca gctggtagcc cgaagtaaca     2160

tcctgacact aatgtatcag tgcatgcagg ataaaatgcc agaagttcga cagagttctt     2220

ttgccctgtt aggtgacctc acaaaagctt gctttcagca tgttaagcct tgtatagctg     2280

atttcatgcc aatattggga accaacctaa atccagaatt catttcagtc tgcaacaatg     2340

ccacatgggc aattggagaa atctccattc aaatgggtat agagatgcag ccttatattc     2400

ctatggtgtt gcaccagctt gtagaaatca ttaacagacc caacacacca aagacgttgt     2460

tagagaatac agcaataaca attggtcgtc ttggttacgt ttgtcctcaa gaggtggccc     2520

ccatgctaca gcagtttata agaccctggt gcacctctct gagaaacata agagacaatg     2580

aggaaaagga ttcagcattc cgtggaattt gtaccatgat cagtgtgaat cccagtggcg     2640

taatccaaga ttttatattt ttttgtgatg ccgttgcatc atggattaac ccaaaagatg     2700

atctcagaga catgttctgt aagatccttc atggatttaa aaatcaagtt ggcgatgaaa     2760

attggaggcg tttctctgac cagtttcctc ttcccttaaa agagcgtctt gcagcttttt     2820

atggtgttta atctaataca cttaagctgc agtcccaaaa ttaggggtcc ttcagtcttg     2880

gagactataa gggagcctct gcacccaggg aaaatgttac cctttacagg ggggaagggt     2940

aaaccagtag ggaatacagt acaatcccaa ccctactggg aggggcggga gggaggtgtt     3000

gccgtcactg tattaagtcg atgttgggaa acgttttaac atctggagcc tttgtgggtg     3060

gaaatatgtc tccagttaca actccgcagt ggatgtgaag aagcaaaaaa aaaaaaatct     3120

attcagtcta ctcacaaaac agtacattgt ggaatattat ggggaattgt accaaaacaa     3180

gaaccatata aatgatgcct agggacaaga aagaggaaca attctatagc gcacaataaa     3240

ggaaacctaa gaatgggagt tacaaatagt aaagaagctt tttttttttt tttaatttaa     3300

agttttttta tgtaagtttt cccacatgat ggggccttgt tttgcatgtt gatgaagaac     3360

tacacaaaga aaactaatat agttaaaagt cagcttgcct tcccgtagta gaagcaggtt     3420

cttggaagtt acaatttaag gtaccccaaa aaagttggaa ataaaacaaa acaaacataa     3480

acaatgaagc accctgtgaa atgccaaatg agtcactcct tttacctttt ttggggtggg     3540

cagggaggga ggaataaatg gggttgggca tatcaaacta aagatgacat cttaattttg     3600

cattgaacat taatgtagcg gatataattt gatgattata cttcattaga tttaatttct     3660

aggccaagat gttacttttt aaagtgcagt ttaaggttca ggcatgcatt ctggctcata     3720

gtggttgaaa gtaatttaaa ttagtgggaa agtagcatgc ttgcatcaca tagagtgaga     3780

ttggtattca tttacctatg ttgcgccagt ttgtgttgca gtttaccaat tcaatatagc     3840

cctgcattta aagttccttt ttaagatttg tggattttat ttttattaag aacatagata     3900

tataaagtac tgtagtttac aggtaggcct tgaaatatct tttttaggat ctgttaggaa     3960

taagattgat attgtattgt gtgtaacctg cacaatgtgg aaagctgata tacctgtgca     4020

aaatctttgc ctctgtgctg tcagtgtgat gtgctttctg catggttata tactactagt     4080

gattttatca aaacttctaa aatttaaatt acgtggtaaa agatctgtaa aaggctgcat     4140

aaatgttagt tggcacataa agacaattgt agaagttgaa aaatgattgc tatatttcaa     4200

tgtttattcc cactcaacat actgccttct aagcttccct ttttttgttc aaagcatgat     4260

cttaaagata tgtttaagtt aatggatgta atgcagggtt cctacactgt attttggcgc     4320

atgttggtgg ccctctgtgc cctagatata tgcacacagg gtgcaagtta aaagctacag     4380

agtgaaagtt ggtttggatc ctcttcattt catttgttta gcttttctgt tatttttctc     4440

tacttacatg tattcctgtg aataaatcct tgttaagtta accctttact tttccttcca     4500

tgtgtatttt cttatatact gtgaatgtga aaacctaact ggtacacttg atcttgtgtt     4560

catatgaaag tgcaagtctt tattaatttg gattgcctga acagtgtatc ccatgatgat     4620

gaaggaaaat ggagagattt ttctttttaa ctctgctggt cagagatgaa gccacgcctt     4680

tccatttttc aatgctgcat atttaatctg caacaaaaat gttaagccat aacagccttt     4740

ttatatttta gtttgtcacc tttgcattgc agaataaata ctgaataacc atttttataa     4800

gcagttgctc ctctttgcat ggttctattc tctaaaagtg ttgaatgata cagccattgc     4860

actgaagttt gagctgtgtg cgtgtgaatt tatactgttt caaaaatttc aaatgcatgg     4920

tagcatgtag aaaggttttt gttactatgt gtgtgtgtgt gttttgtttt gttttgttct     4980

gttttttaac gttctttcac ctttcctcta ctttggcttt gcaaatttca gtctgtagag     5040

cctgaaatta aattatttta tagtgcctga tatttttaat attataagtt ggattcaaag     5100

ggtatacagc attttgtttt ctagtaccat tgcttcactg ggagctcaaa atttgcctcc     5160

ctgttagtct ttaataactg agtagagtag cttttttatt cttagattat agtgatattc     5220

tgtagtgctt caaatactta gaattctaat atgagagata gtttaatatt ctggaataga     5280

gagtatttta aattgaaatg accaaattcg atttaaaaca aacacataac aatcttcagt     5340

aaagttattt gaacctgtgg ttgacaattc tgtattgact aaaggcaata ttgtcacctg     5400

tctcattaaa aattagtttc cagttaggca gatgaataac actattaaaa atgcacccag     5460

ttttgtagtc acttgacttt ttttttttat ttaaatgaaa tttaatttga aaatagaaaa     5520

taaaattagg taaatatgac tggcaacctg aatttgagtt gggattcttt gtgtattttt     5580

cccccttgag gttattgttt cttcctaatt tatatttcag atacatagtg tagaacagga     5640

atttgcagaa gccatttaag ttatcttttg aggtaagctc tgatttagca tttattctga     5700

taaaatctaa tacatcatgg gatatatata aagcaactta attcttgtgg tgtagtctta     5760

atagttttga atgttgactg aatgtctata aaattgtgag tttgtctttg ttacattcca     5820

gtgtttctgc ctcttggcat gcttaaagca cggcttactt catctgctcc ttacacacta     5880

aaatgctgtt agtgtgctca actacagaaa tagccgctgc taagtgatgt agattttcta     5940

cttgaatatt tttatgttgt aggaacctca ggaggtcagt gtttactgtt ttatatatgc     6000

cttctttttc ctgtttgagc ttctctcttt gaaggattct aacagaacaa agctgctgat     6060

caacctaagt tggaaacaga aagtgtaatt aatataactt aaatgcatgt ttggcagttc     6120

catgttacag tccattagcg agtgaactta gtgccacagg tattcattta ttcaggaaag     6180

aattttgctt tttgtattgt ctaatctctt caatgacttc atactgtgta aaaaaaaatc     6240

actttttaat attttttggt tggttatttc ccaaataatc aacatgtaaa taatctttta     6300

agagccagtt ctgatgcttt acattattgc tacttgattt tgttatgcaa gttagatttc     6360

agaagaatag attttaaaac acttaaccaa gccattacat cttaaaaaca aaacaagtag     6420

catacatttt gtaattaaca ttgataaaca ctgtgatttt tttggttaag actttttcat     6480

tgatctgaat tgcttaaatt gcatatattg taaaatagga tcagatgtat attttaaact     6540

aatttcaatg gattttcctc ttgaaatgct ttgtctactc agttataaaa tattcagata     6600

caagttttat ctcaggtgaa tactcttgta ttgtttttgc tttggtgaca tgcttataaa     6660

gggtcatcct agttacattc tttgtttttt aagtgtattt cattgagaat ctttccattt     6720

agtctgattt ttttcctaat attctagcag gctggggtgg tataaagccc tcctgacaag     6780

ccttttgcct acaggtttac ctgaaaatga gctacatatg gtcgtcattt tcttcaaact     6840

ctcaaaatag gaaagtggaa atttttctcc cctatataaa attattctgc ctagcagaaa     6900

tgccagaaat aaattaattg catcttagtc taaatttaag tcctttgcca tgaggaaaaa     6960

gtggtttttt gcttcatatg gtaaatctat attattcata ttgaatgtat taacagataa     7020

tggtgcaaaa gcattcttcc caggggaaga gtgtatcatg cataactgca atttaagtcc     7080

ttcctttgat aatacttcaa aacatacaca gctttgctta ctgaattatt tttgcaaata     7140

atacaaggag gggaaactaa cttgctacta gtgttgttaa tgaagtatag gccttggaac     7200

atttaagaaa actggtcttc agatagttaa gggcttggga taatttaagt gaaaagtgag     7260

atcagtaatg agctgtgttg ttaacaatat tatctggtaa taataccatg caatatagcg     7320

ttgtatacca acttagtgca ttttatactg tattaaatat ggagatactt ctaatgcctc     7380

tctaaaatta aattttacat aaaagttagt tttattcacc tttaggcttt ccaagtgaat     7440

tgtgactaat tttttcaatc ttacatagat ctttcaccca ttagcattac ttacgtagat     7500

aattctttat gcctagttat tatacatatt aatttttaag gtatacattt aaattacaca     7560

attgttcatt gtggtttgta tcccagaatg tgttgtgttt tttaaaagat gcataatagc     7620

tgaatgtatg catgactttg aaagaagtta aaatggtgat tttttttcac ctcttgtaca     7680

ttttaaaacc aggccaaatc tatttgccaa gcagtgtatc actaataaga aaagcagttt     7740

ttccttttat tgcagttttt gtttatctgc catagaattt ccttatactg tggcttggta     7800

ttattcaaga ttagctattt cgctggtatt acatcttttt aaaagcctat tataacatgg     7860

ttagcctata aggcagtgtt ggtccccttc taatattggc ctcataaagg ggttccactg     7920

tactttccgc atattactgt gttgttgttt tcctttgtgg atatataagc aaattgagct     7980

tgggtgattt ttatggagac aataattaga caatactgta taattagttt tacttaatag     8040

attatcatct tgtgagaaga gatgtttaaa cgtggtaaat cacttcatat tacaaaacag     8100

ttttacactt aatatgttaa cattgggtgc aataatttag tagcattagc tttagttaca     8160

aatataactg gatctttctg ctgacaactt aggttgtatg agttatgctt aaaagcttta     8220

aatctgatgt ttcctgtacc tgccacacta tgttagaatg tgtccttcaa acatatcctc     8280

ctgcaacttc tcaaactgta ctaaattgat atttcttgaa gtctaactct gtgctaacag     8340

atctccattt taaatagaat acggttttaa tttttgataa gctgctgaat tttaaagaga     8400

gttttttggg gccaccaaat attttggatc atgcagagaa tatatattgt actgtagtaa     8460

ttttgtattt acatttgtat gatgtgacat aatagatgtg aatgttaatc actgcttgac     8520

tatgttaata aagttgttta actata                                          8546


<210>  502
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Glu Tyr Glu Trp Lys Pro Asp Glu Gln Gly Leu Gln Gln Ile Leu 
1               5                   10                  15      


Gln Leu Leu Lys Glu Ser Gln Ser Pro Asp Thr Thr Ile Gln Arg Thr 
            20                  25                  30          


Val Gln Gln Lys Leu Glu Gln Leu Asn Gln Tyr Pro Asp Phe Asn Asn 
        35                  40                  45              


Tyr Leu Ile Phe Val Leu Thr Lys Leu Lys Ser Glu Asp Glu Pro Thr 
    50                  55                  60                  


Arg Ser Leu Ser Gly Leu Ile Leu Lys Asn Asn Val Lys Ala His Phe 
65                  70                  75                  80  


Gln Asn Phe Pro Asn Gly Val Thr Asp Phe Ile Lys Ser Glu Cys Leu 
                85                  90                  95      


Asn Asn Ile Gly Asp Ser Ser Pro Leu Ile Arg Ala Thr Val Gly Ile 
            100                 105                 110         


Leu Ile Thr Thr Ile Ala Ser Lys Gly Glu Leu Gln Asn Trp Pro Asp 
        115                 120                 125             


Leu Leu Pro Lys Leu Cys Ser Leu Leu Asp Ser Glu Asp Tyr Asn Thr 
    130                 135                 140                 


Cys Glu Gly Ala Phe Gly Ala Leu Gln Lys Ile Cys Glu Asp Ser Ala 
145                 150                 155                 160 


Glu Ile Leu Asp Ser Asp Val Leu Asp Arg Pro Leu Asn Ile Met Ile 
                165                 170                 175     


Pro Lys Phe Leu Gln Phe Phe Lys His Ser Ser Pro Lys Ile Arg Ser 
            180                 185                 190         


His Ala Val Ala Cys Val Asn Gln Phe Ile Ile Ser Arg Thr Gln Ala 
        195                 200                 205             


Leu Met Leu His Ile Asp Ser Phe Ile Glu Asn Leu Phe Ala Leu Ala 
    210                 215                 220                 


Gly Asp Glu Glu Pro Glu Val Arg Lys Asn Val Cys Arg Ala Leu Val 
225                 230                 235                 240 


Met Leu Leu Glu Val Arg Met Asp Arg Leu Leu Pro His Met His Asn 
                245                 250                 255     


Ile Val Glu Tyr Met Leu Gln Arg Thr Gln Asp Gln Asp Glu Asn Val 
            260                 265                 270         


Ala Leu Glu Ala Cys Glu Phe Trp Leu Thr Leu Ala Glu Gln Pro Ile 
        275                 280                 285             


Cys Lys Asp Val Leu Val Arg His Leu Pro Lys Leu Ile Pro Val Leu 
    290                 295                 300                 


Val Asn Gly Met Lys Tyr Ser Asp Ile Asp Ile Ile Leu Leu Lys Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asp Glu Thr Ile Pro Asp Ser Glu Gln Asp Ile Arg 
                325                 330                 335     


Pro Arg Phe His Arg Ser Arg Thr Val Ala Gln Gln His Asp Glu Asp 
            340                 345                 350         


Gly Ile Glu Glu Glu Asp Asp Asp Asp Asp Glu Ile Asp Asp Asp Asp 
        355                 360                 365             


Thr Ile Ser Asp Trp Asn Leu Arg Lys Cys Ser Ala Ala Ala Leu Asp 
    370                 375                 380                 


Val Leu Ala Asn Val Tyr Arg Asp Glu Leu Leu Pro His Ile Leu Pro 
385                 390                 395                 400 


Leu Leu Lys Glu Leu Leu Phe His His Glu Trp Val Val Lys Glu Ser 
                405                 410                 415     


Gly Ile Leu Val Leu Gly Ala Ile Ala Glu Gly Cys Met Gln Gly Met 
            420                 425                 430         


Ile Pro Tyr Leu Pro Glu Leu Ile Pro His Leu Ile Gln Cys Leu Ser 
        435                 440                 445             


Asp Lys Lys Ala Leu Val Arg Ser Ile Thr Cys Trp Thr Leu Ser Arg 
    450                 455                 460                 


Tyr Ala His Trp Val Val Ser Gln Pro Pro Asp Thr Tyr Leu Lys Pro 
465                 470                 475                 480 


Leu Met Thr Glu Leu Leu Lys Arg Ile Leu Asp Ser Asn Lys Arg Val 
                485                 490                 495     


Gln Glu Ala Ala Cys Ser Ala Phe Ala Thr Leu Glu Glu Glu Ala Cys 
            500                 505                 510         


Thr Glu Leu Val Pro Tyr Leu Ala Tyr Ile Leu Asp Thr Leu Val Phe 
        515                 520                 525             


Ala Phe Ser Lys Tyr Gln His Lys Asn Leu Leu Ile Leu Tyr Asp Ala 
    530                 535                 540                 


Ile Gly Thr Leu Ala Asp Ser Val Gly His His Leu Asn Lys Pro Glu 
545                 550                 555                 560 


Tyr Ile Gln Met Leu Met Pro Pro Leu Ile Gln Lys Trp Asn Met Leu 
                565                 570                 575     


Lys Asp Glu Asp Lys Asp Leu Phe Pro Leu Leu Glu Cys Leu Ser Ser 
            580                 585                 590         


Val Ala Thr Ala Leu Gln Ser Gly Phe Leu Pro Tyr Cys Glu Pro Val 
        595                 600                 605             


Tyr Gln Arg Cys Val Asn Leu Val Gln Lys Thr Leu Ala Gln Ala Met 
    610                 615                 620                 


Leu Asn Asn Ala Gln Pro Asp Gln Tyr Glu Ala Pro Asp Lys Asp Phe 
625                 630                 635                 640 


Met Ile Val Ala Leu Asp Leu Leu Ser Gly Leu Ala Glu Gly Leu Gly 
                645                 650                 655     


Gly Asn Ile Glu Gln Leu Val Ala Arg Ser Asn Ile Leu Thr Leu Met 
            660                 665                 670         


Tyr Gln Cys Met Gln Asp Lys Met Pro Glu Val Arg Gln Ser Ser Phe 
        675                 680                 685             


Ala Leu Leu Gly Asp Leu Thr Lys Ala Cys Phe Gln His Val Lys Pro 
    690                 695                 700                 


Cys Ile Ala Asp Phe Met Pro Ile Leu Gly Thr Asn Leu Asn Pro Glu 
705                 710                 715                 720 


Phe Ile Ser Val Cys Asn Asn Ala Thr Trp Ala Ile Gly Glu Ile Ser 
                725                 730                 735     


Ile Gln Met Gly Ile Glu Met Gln Pro Tyr Ile Pro Met Val Leu His 
            740                 745                 750         


Gln Leu Val Glu Ile Ile Asn Arg Pro Asn Thr Pro Lys Thr Leu Leu 
        755                 760                 765             


Glu Asn Thr Ala Ile Thr Ile Gly Arg Leu Gly Tyr Val Cys Pro Gln 
    770                 775                 780                 


Glu Val Ala Pro Met Leu Gln Gln Phe Ile Arg Pro Trp Cys Thr Ser 
785                 790                 795                 800 


Leu Arg Asn Ile Arg Asp Asn Glu Glu Lys Asp Ser Ala Phe Arg Gly 
                805                 810                 815     


Ile Cys Thr Met Ile Ser Val Asn Pro Ser Gly Val Ile Gln Asp Phe 
            820                 825                 830         


Ile Phe Phe Cys Asp Ala Val Ala Ser Trp Ile Asn Pro Lys Asp Asp 
        835                 840                 845             


Leu Arg Asp Met Phe Cys Lys Ile Leu His Gly Phe Lys Asn Gln Val 
    850                 855                 860                 


Gly Asp Glu Asn Trp Arg Arg Phe Ser Asp Gln Phe Pro Leu Pro Leu 
865                 870                 875                 880 


Lys Glu Arg Leu Ala Ala Phe Tyr Gly Val 
                885                 890 


<210>  503
<211>  3676
<212>  DNA
<213>  Homo sapiens

<400>  503
ggccgagggg gcatcatgaa gcgggctggc ggcgctgccg ctcccgggcg gccgcgggcg       60

ggaggtgctt cccaaggacc gtagatgcct ctctagagca tgagctcagg caagagtgcc      120

cgctacaacc gcttctccgg ggggcccagc aatcttccca ccccagacgt caccacaggg      180

accagaatgg aaacgacctt cggacccgcc ttttcagccg tcaccaccat cacaaaagct      240

gacgggacca gcacctacaa gcagcactgc aggacaccct cctcctccag cacccttgcc      300

tactccccgc gggacgagga ggacagcatg ccccccatca gcactccccg ccgctccgac      360

tccgccatct ctgtccgctc cctgcactca gagtccagca tgtctctgcg ctccacattc      420

tcactgcccg aggaggagga ggagccggag ccactggtgt ttgcggagca gccctcggtg      480

aagctgtgct gtcagctctg ctgcagcgtc ttcaaagacc ccgtgatcac cacgtgtggg      540

cacacgttct gtaggagatg cgccttgaag tcagagaagt gtcccgtgga caacgtcaaa      600

ctgaccgtgg tggtgaacaa catcgcggtg gccgagcaga tcggggagct cttcatccac      660

tgccggcacg gctgccgggt agcgggcagc gggaagcccc ccatctttga ggtggacccc      720

cgagggtgcc ccttcaccat caagctcagc gcccggaagg accacgaggg cagctgtgac      780

tacaggcctg tgcggtgtcc caacaacccc agctgccccc cgctgctcag gatgaacctg      840

gaggcccacc tcaaggagtg cgagcacatc aaatgccccc actccaagta cgggtgcacg      900

ttcatcggga accaggacac ttacgagacc cacctggaga cttgccgctt cgagggcctg      960

aaggagtttc tgcagcagac ggatgaccgc ttccacgaga tgcacgtggc tctggcccag     1020

aaggaccagg agatcgcctt cctgcgctcc atgctgggaa agctctcgga gaagatcgac     1080

cagctagaga agagcctgga gctcaagttt gacgtcctgg acgaaaacca gagcaagctc     1140

agcgaggacc tcatggagtt ccggcgggac gcatccatgt taaatgacga gctgtcccac     1200

atcaacgcgc ggctgaacat gggcatccta ggctcctacg accctcagca gatcttcaag     1260

tgcaaaggga cctttgtggg ccaccagggc cctgtgtggt gtctctgcgt ctactccatg     1320

ggtgacctgc tcttcagtgg ctcctctgac aagaccatca aggtgtggga cacatgtacc     1380

acctacaagt gtcagaagac actggagggc catgatggca tcgtgctggc tctctgcatc     1440

caggggtgca aactctacag cggctctgca gactgcacca tcattgtgtg ggacatccag     1500

aacctgcaga aggtgaacac catccgggcc catgacaacc cggtgtgcac gctggtctcc     1560

tcacacaacg tgctcttcag cggctccctg aaggccatca aggtctggga catcgtgggc     1620

actgagctga agttgaagaa ggagctcaca ggcctcaacc actgggtgcg ggccctggtg     1680

gctgcccaga gctacctgta cagcggctcc taccagacaa tcaagatctg ggacatccga     1740

acccttgact gcatccacgt cctgcagacg tctggtggca gcgtctactc cattgctgtg     1800

acaaatcacc acattgtctg tggcacctac gagaacctca tccacgtgtg ggacattgag     1860

tccaaggagc aggtgcggac cctcacgggc cacgtgggca ccgtgtatgc cctggcggtc     1920

atctcgacgc cagaccagac caaagtcttc agtgcatcct acgaccggtc cctcagggtc     1980

tggagtatgg acaacatgat ctgcacgcag accctgctgc gtcaccaggg cagtgtcacc     2040

gcgctggctg tgtcccgggg ccgactcttc tcaggggctg tggatagcac tgtgaaggtt     2100

tggacttgct aacaggatcc aggccaggct gtggtttccc ctgaaccagc cctggacctt     2160

tctgagccag gctggccaca tggggtggtc tcggggtttc tgcctgcccc gtgggcatag     2220

gtggacaggc tctggcagcc gggcagtgcc ctccccgtcc catgctcggc gagcctccct     2280

ctactcggca ctgtccttgc tgcccagccc ctctctgggt gccaggtacg acgcttgccc     2340

cggcccaccc tccatcccca ccctccatcc ccaccctaga tggagcgagg gcctttttac     2400

tcaccttttc taccgttttt agactgtatg tagatttggt tacctcctgg ttgaaataaa     2460

tgctccacag actgtggctg tgagtgggga cagctcctcg ggacaagggg gctgtgtgtg     2520

gccttgaggt tggtgtgcac aggcactggc tgctgtgagt gggggggcat ggggcagttt     2580

cctttggtgg accccaggac ttcggcccac tccggggcct cccctccctg ctaggaggca     2640

actcgtcaca cccaagctgc tggcctccag tcccatctcc cccaacacat gtgcccccaa     2700

aaagtgagcc aggcacctct gtttcctgct gtttattgac agccgacggc agcgccttgc     2760

ccagacctcc cctgcccacc tgctggagcc cagcctgtgc cgccctctga ggagaggcct     2820

ggggggacag ctgggcacgt ccactcgcag ggaaacacgg ggtgagacag caggaagggg     2880

ccctgcacgc cgggacgcca cctccgccag ccgcctccac ccgccccaca ccacaatcgc     2940

tggttttcgg cattttttaa attttttttt taagaaacgt caaagttgtg cccaacactg     3000

tggatcagca aacacgatag aggagaccag tcagtacttc ttggaggggg caggaggaga     3060

gaggaaaagg gagggcgaga atgaccacac aacacagcct tggaccatga gcagaagcgt     3120

ccgtgggaac tccactgggg tggatgggct gcctgcacag cccctggaga gggggccagg     3180

cacaccctca gaggagctgc aagcccgtgg cctggcctgc tacatgccct gcttccacgt     3240

ggctgccacg ctgacacacc cacattcacc aaacccaccc gcgccctggg acgcagccac     3300

gccaggagga ggacacggcc gccgagagca aggcacaacc tcgagttctt ggggcgcaga     3360

gaacttagga gagaagcacg gaggagcccc cggcagagca cccgcccccg ggccccagcc     3420

ttccacctgt gctagcagcc tggggcctcc actctggccg gaggaaggac cgcaggcaga     3480

cagcctgggc ctctaacagc ttttgtccgg agctagactt cgtgtccttt cagttggtaa     3540

atggttttct atagaatcaa taatatttct ttctttaaat atatatttgt taaagttata     3600

cctttttgtt tctctgggga aatccgcctc agctcattcc caataaatta atactcttga     3660

tagcttaaaa aaaaaa                                                     3676


<210>  504
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Ser Ser Gly Lys Ser Ala Arg Tyr Asn Arg Phe Ser Gly Gly Pro 
1               5                   10                  15      


Ser Asn Leu Pro Thr Pro Asp Val Thr Thr Gly Thr Arg Met Glu Thr 
            20                  25                  30          


Thr Phe Gly Pro Ala Phe Ser Ala Val Thr Thr Ile Thr Lys Ala Asp 
        35                  40                  45              


Gly Thr Ser Thr Tyr Lys Gln His Cys Arg Thr Pro Ser Ser Ser Ser 
    50                  55                  60                  


Thr Leu Ala Tyr Ser Pro Arg Asp Glu Glu Asp Ser Met Pro Pro Ile 
65                  70                  75                  80  


Ser Thr Pro Arg Arg Ser Asp Ser Ala Ile Ser Val Arg Ser Leu His 
                85                  90                  95      


Ser Glu Ser Ser Met Ser Leu Arg Ser Thr Phe Ser Leu Pro Glu Glu 
            100                 105                 110         


Glu Glu Glu Pro Glu Pro Leu Val Phe Ala Glu Gln Pro Ser Val Lys 
        115                 120                 125             


Leu Cys Cys Gln Leu Cys Cys Ser Val Phe Lys Asp Pro Val Ile Thr 
    130                 135                 140                 


Thr Cys Gly His Thr Phe Cys Arg Arg Cys Ala Leu Lys Ser Glu Lys 
145                 150                 155                 160 


Cys Pro Val Asp Asn Val Lys Leu Thr Val Val Val Asn Asn Ile Ala 
                165                 170                 175     


Val Ala Glu Gln Ile Gly Glu Leu Phe Ile His Cys Arg His Gly Cys 
            180                 185                 190         


Arg Val Ala Gly Ser Gly Lys Pro Pro Ile Phe Glu Val Asp Pro Arg 
        195                 200                 205             


Gly Cys Pro Phe Thr Ile Lys Leu Ser Ala Arg Lys Asp His Glu Gly 
    210                 215                 220                 


Ser Cys Asp Tyr Arg Pro Val Arg Cys Pro Asn Asn Pro Ser Cys Pro 
225                 230                 235                 240 


Pro Leu Leu Arg Met Asn Leu Glu Ala His Leu Lys Glu Cys Glu His 
                245                 250                 255     


Ile Lys Cys Pro His Ser Lys Tyr Gly Cys Thr Phe Ile Gly Asn Gln 
            260                 265                 270         


Asp Thr Tyr Glu Thr His Leu Glu Thr Cys Arg Phe Glu Gly Leu Lys 
        275                 280                 285             


Glu Phe Leu Gln Gln Thr Asp Asp Arg Phe His Glu Met His Val Ala 
    290                 295                 300                 


Leu Ala Gln Lys Asp Gln Glu Ile Ala Phe Leu Arg Ser Met Leu Gly 
305                 310                 315                 320 


Lys Leu Ser Glu Lys Ile Asp Gln Leu Glu Lys Ser Leu Glu Leu Lys 
                325                 330                 335     


Phe Asp Val Leu Asp Glu Asn Gln Ser Lys Leu Ser Glu Asp Leu Met 
            340                 345                 350         


Glu Phe Arg Arg Asp Ala Ser Met Leu Asn Asp Glu Leu Ser His Ile 
        355                 360                 365             


Asn Ala Arg Leu Asn Met Gly Ile Leu Gly Ser Tyr Asp Pro Gln Gln 
    370                 375                 380                 


Ile Phe Lys Cys Lys Gly Thr Phe Val Gly His Gln Gly Pro Val Trp 
385                 390                 395                 400 


Cys Leu Cys Val Tyr Ser Met Gly Asp Leu Leu Phe Ser Gly Ser Ser 
                405                 410                 415     


Asp Lys Thr Ile Lys Val Trp Asp Thr Cys Thr Thr Tyr Lys Cys Gln 
            420                 425                 430         


Lys Thr Leu Glu Gly His Asp Gly Ile Val Leu Ala Leu Cys Ile Gln 
        435                 440                 445             


Gly Cys Lys Leu Tyr Ser Gly Ser Ala Asp Cys Thr Ile Ile Val Trp 
    450                 455                 460                 


Asp Ile Gln Asn Leu Gln Lys Val Asn Thr Ile Arg Ala His Asp Asn 
465                 470                 475                 480 


Pro Val Cys Thr Leu Val Ser Ser His Asn Val Leu Phe Ser Gly Ser 
                485                 490                 495     


Leu Lys Ala Ile Lys Val Trp Asp Ile Val Gly Thr Glu Leu Lys Leu 
            500                 505                 510         


Lys Lys Glu Leu Thr Gly Leu Asn His Trp Val Arg Ala Leu Val Ala 
        515                 520                 525             


Ala Gln Ser Tyr Leu Tyr Ser Gly Ser Tyr Gln Thr Ile Lys Ile Trp 
    530                 535                 540                 


Asp Ile Arg Thr Leu Asp Cys Ile His Val Leu Gln Thr Ser Gly Gly 
545                 550                 555                 560 


Ser Val Tyr Ser Ile Ala Val Thr Asn His His Ile Val Cys Gly Thr 
                565                 570                 575     


Tyr Glu Asn Leu Ile His Val Trp Asp Ile Glu Ser Lys Glu Gln Val 
            580                 585                 590         


Arg Thr Leu Thr Gly His Val Gly Thr Val Tyr Ala Leu Ala Val Ile 
        595                 600                 605             


Ser Thr Pro Asp Gln Thr Lys Val Phe Ser Ala Ser Tyr Asp Arg Ser 
    610                 615                 620                 


Leu Arg Val Trp Ser Met Asp Asn Met Ile Cys Thr Gln Thr Leu Leu 
625                 630                 635                 640 


Arg His Gln Gly Ser Val Thr Ala Leu Ala Val Ser Arg Gly Arg Leu 
                645                 650                 655     


Phe Ser Gly Ala Val Asp Ser Thr Val Lys Val Trp Thr Cys 
            660                 665                 670 


<210>  505
<211>  9753
<212>  DNA
<213>  Homo sapiens

<400>  505
gacagatttc aatgtctgtt gaaggccccc ccacaccctc cttcagtgcc gggggcatgg       60

agggatatct tgggctcctg ctgtttttta aaatgatgcg agctcatctc ctgtcctggg      120

tgtgaacgag tatatcttac cagggatgta actgaacatt tttttctgca ttgtgttcct      180

actgagcaac ccaagatggc caggaactgc tctgagtgca aggagaagag ggcagcacat      240

atcctctgca cctactgcaa tcgctggctg tgcagctctt gcacagagga acaccgacac      300

agccctgtcc ccgggggccc attctttcct cgggcccaga agggatctcc aggagtgaat      360

ggtggtcccg gagacttcac cttgtattgt cctctacaca cacaggaagt actcaagcta      420

ttctgtgaga catgtgatat gctcacttgc catagctgcc tagtggtgga acacaaagaa      480

cacaggtgca gacatgttga agaagttttg caaaaccaga ggatgcttct ggaaggtgtg      540

actacacagg tggcacataa gaaatccagt ctacagacat ctgcaaagca aattgaggac      600

aggatttttg aagtgaagca tcagcatagg aaggtggaaa accagatcaa aatggccaag      660

atggttctga tgaatgagct gaacaaacag gccaatgggc taatagagga attagagggg      720

attactaatg agagaaagcg gaagctggaa cagcagttac agagcatcat ggttctcaac      780

cgtcagtttg agcatgtgca gaatttcatc aactgggctg tctgcagcaa aaccagtgtc      840

ccttttcttt tcagcaaaga gctgattgtg tttcagatgc agcgattgct ggagacaagt      900

tgtaacacag atcctggctc cccttggagt atcagattca cctgggagcc taacttctgg      960

accaagcagc tagcttctct tggctgcata actactgaag gtggacaaat gtccagggca     1020

gatgctcctg cttatggagg cttacagggg tcatcaccct tttatcaaag ccaccagtct     1080

ccagtggctc agcaagaggc tcttagccac ccctcacaca agttccagtc tccagcagtg     1140

tgctcctcat ctgtgtgctg ctcccactgc tccccagtct cgccttccct caaaggccag     1200

gtccccccac ccagcataca cccagcccac agcttcaggc agccccctga gatggtgccc     1260

cagcagctgg ggtctctgca gtgctctgcc ctgctgccca gggagaaaga gctggcctgc     1320

agccctcatc caccaaagct gctgcagccc tggctggaaa cccagccccc cgtggagcag     1380

gagagcacat cccagcggct ggggcagcag ctgacttccc agcccgtgtg cattgtcccc     1440

ccacaggatg ttcagcaagg agcccatgcc cagcccacct tacagacacc ctctatccaa     1500

gtccagtttg gccaccacca gaagctgaag ctcagtcact ttcagcagca gccacagcag     1560

cagctaccac ctccaccacc acccctcccc catcccccac ctccccttcc ccctccccca     1620

cagcagccac acccacctct tcctccatcc cagcatctgg cttctagtca gcacgagagc     1680

cctcctggcc ctgcctgttc tcagaacatg gacataatgc atcacaagtt tgagctggag     1740

gaaatgcaga aggacttgga gcttcttctc caggctcaac agcccagcct gcaactgagt     1800

cagaccaaat ctcctcagca tcttcagcaa accattgtgg ggcagatcaa ctacatcgtg     1860

aggcagccag cacctgtcca gtcccagagc caggaggaga ccctgcaggc tacagatgag     1920

cccccagcat ctcagggctc aaagccggct ctccctcttg acaagaatac tgctgctgcc     1980

ttgccccagg cgtctgggga agaaacccct ctcagtgtcc ccccagtgga cagcaccatc     2040

cagcactcct ctccaaatgt ggtgagaaag cactccacct cgctgagcat catgggcttt     2100

tccaacactc tggagatgga gttgtcatct accaggttgg agaggcccct agagccacag     2160

atccagagtg tgagcaacct gacagctggt gccccccagg cagtaccaag cctgctgagt     2220

gctcccccca aaatggtgtc cagcctgaca agtgttcaaa accaggccat gcccagcctg     2280

acaaccagtc acctacagac tgtgcccagc cttgtgcata gcacattcca gtccatgccc     2340

aacctgataa gtgactcccc tcaggctatg gcaagcctgg caagtgatca ccctcaggct     2400

gggcccagcc taatgtctgg tcacacccag gctgtgccga gtctggcaac ttgtcctctg     2460

cagagcatcc ctccagtttc tgacatgcag ccagaaactg ggtccagctc cagttctggc     2520

cgaacttcag ggagcctgtg tcccagagat ggggctgatc cctccctgga gaatgctctg     2580

tgtaaggtaa aactggagga gccaattaac ctctctgtga agaaacctcc actggcgcca     2640

gtggtcagca cgtctacagc tctgcagcag taccagaacc caaaagagtg tgagaatttt     2700

gaacaaggag ccctagagct ggatgcaaaa gagaaccaga gcatcagagc cttcaatagt     2760

gagcataaga ttccctatgt gcgactggag cgactcaaga tctgtgctgc ctcctcagga     2820

gagatgcctg tgttcaaact gaagccacag aagaatgatc aggatgggag cttcctgctg     2880

atcatcgagt gtggcactga gtcctccagc atgtccatta aggtcagcca ggacagactg     2940

tctgaggcca cccaggcccc aggtctggag ggaagaaagg tcactgtcac ttctttggct     3000

gggcagcggc caccagaagt ggagggcaca tctcctgaag aacacagact cattcctcga     3060

accccaggag ccaagaaggg ccccccagcc ccaatagaga atgaggactt ctgtgctgtt     3120

tgcctcaatg gcggagagtt actgtgctgt gaccgctgcc ccaaagtgtt ccacctctcc     3180

tgccatgtgc cagccttgct cagcttccca gggggagagt gggtgtgtac cttgtgccgc     3240

agcctgaccc agcccgagat ggagtacgac tgtgagaatg cctgctataa ccagcctgga     3300

atgcgggcat ctcctggcct aagcatgtat gaccagaaga agtgtgagaa gctggtattg     3360

tccttgtgct gcaataacct cagcctgccc ttccatgaac ctgtcagccc cctggcccgg     3420

cattattacc agattatcaa gaggcccatg gacctgtcaa tcatccggag gaagctgcaa     3480

aagaaggacc cagctcacta taccacccca gaggaggtgg tatcagatgt gcgcctcatg     3540

ttctggaact gtgctaagtt caattatcct gactccgagg ttgcagaggc tggccgctgc     3600

ctggaagtgt tctttgaggg ctggttgaag gagatctacc cggagaaacg gtttgcccag     3660

ccaaggcagg aggactcaga ctccgaggag gtgtctagtg agagtggatg ttccactccc     3720

cagggcttcc cgtggcctcc ctacatgcag gagggcatcc aacccaagag gcggcgacga     3780

catatggaga atgaaagagc aaaaagaatg tcatttcgcc tggccaacag catctctcag     3840

gtgtgagagc caaaaggaga ctgggcactc tggcagctgt tgtcccatac tgtcgaccat     3900

tcctccccat cttgcagctt atcctcttca gagtgtggat ggtagatgag tcttgttgaa     3960

ctgtgtagtg ctcttctttg ccatttgcat ctacagcatt tatttgggag ccgtagtaca     4020

tccactacag agaagatttc agtaataaac aggaaagagg aaggtattta ttattaccag     4080

agtaatcaga tgtataggct ccacttgaca agaccacacc tggttaggct cgggaaaacc     4140

tactttcctt ggtgaatttt tttctgcctg ggaaagcaga cccgtctaac cttttagtgt     4200

ccagggctca ggagccatgt atacatctga actcctcctg ggctcagaag tgggtaaaag     4260

aagggagaga ggtttagaca tatggcagga ctgtgatccc tggcccagca cagccaaaga     4320

ctgtcactgt ttgcctttgc ttgtcctgtc tggatagagg cacctgccat gtgcagacta     4380

gtggaggctt ctagaggcca taggtctcaa tttgtgccta tttgggttct aacggttttc     4440

agggtatttg ttttgcatag tcactttcct gatgttgaca taggtggctg ctgtgaaaat     4500

gctgtggatg gtgtgacatt cttgactgag ctgggtggct gtggagagac cacttaaatc     4560

ttctggttca gatttcactt acagacttag taagatgtcc acttcagagc ccgccctctg     4620

tgctacttac tctgggctaa tcacacttct ttagggtgag aacctgcctt cctagaagtg     4680

actgttggtg cttgtcagtg gccataccct tcatcatcct cattcagagg tatggatcgt     4740

gagttctgct tgtgaatact gtgagacagc tgctgtctgc ttcaggtcca gagttccatg     4800

ggtggagaga gtaacccaca accagctcac tcctctgggc ctctcctcct gcttaaagat     4860

tctagttctc aacctctcca agttcatgag ccaaagatca gaagtgagtc ttctgaccag     4920

cccgcctcca ggctgtctac agccccaaaa aagccaacac ttttctggca gccctttttg     4980

ttggaggtta gagaaggcct cagggaccaa caggggccag atctagacat tcctggggga     5040

agtttgtcta aggtggacag ggggaaaaat caagaggcaa aaagccagtg tcctttggtg     5100

accatgaagc aacctcagag ccttagttct cctagaatgc agagagaagc attctggaag     5160

ccatgggaac aggagctcga ggctgcatcc tgaatgcatc tgcatggccc tcgcagggtg     5220

tttgtgagga tactggaggt caggctacct cccaagcaag ggcttggttg agaaggaacc     5280

cattgctcat attgttgggg gagctatgaa cctgacatgt cagtggccag gactgagaca     5340

gctctccctg gtcctgtcat tgcatggcta atttcagggg agtctgaggt catggcttta     5400

tttttgctaa cagatgaagt tcaaggatgt tcttgtttgt agggcctttg ctaatgagca     5460

gttttttaat tagaaaacat ttcttctctc tttgtgagtt gatggtattg ctcatttcct     5520

tctctaccca acctgagaga tcatcttcac tttaaagcaa accatgcccc ttggcttgcc     5580

attctttcag cagcacatgc cacgttctaa gcagatgggc ttccgtgatc ccgttttcta     5640

gtttggggta actgagtctt gaatgcttta ctagtccggc aatctttgga cttaggcttc     5700

tgccctttga gactcacatg actttctggt ttggggtctg gtcatttccc tttcaatttt     5760

tgaatctcct tctctgttca gttggcttgg caaagtaccc tctgttctca tgtcactaat     5820

tcctgctcta ggtcatcttt cctttgtgca gcccacattc ccaccatcct gtgaactttg     5880

ttgtacttgg tgttgggcaa ctggtgagtg ttgtgacagg ctcagacctg atccttcctc     5940

aggagcaatt ggagaccaca aatttaaagc agaaatacct gttaaaagct tggctttcct     6000

tatatgagtg aggctcccag cttgggtgtg gcctcctggg ctcacggatc agcttgctgg     6060

gccagagggg gtcttagtaa tgtgctagag agacacatgc tcccttctca tcgtagagag     6120

cctgcatgct gagaggctcc ctttacacac ctgcctctcg ctggcttttc ctttagacct     6180

agccaccagt gttttgaatc atggttttgt tttgtttttg catgcaaaaa ccagaacatg     6240

acttagaaat taaaaaaaaa aaaatcctac tagccaagtg actgcctgca gaggctcttc     6300

attaacattt gggctgatcc tgcttttgac ttattcccat aatggcccag ttttgaagtc     6360

agccaagtcc ttttgtcctt gacaacatca tgcagtggaa atacggtgag ttctagattc     6420

ttatgggaca gcatgcagcc ctagaggaaa aattgacttc ttgggtatgc tgagaaataa     6480

gacagtaaaa tggcttcagt tgatgcaagg ggattttagt taaaaattgg ttcaggattt     6540

ttaaatttta ttttattttt tggctgggcg cggtggctca cgcctgtaat cccagcactt     6600

tgggaggctg aggtgggtgg atcacctaag gacagcagtt cgagaccagc ctggccaaca     6660

tagtgaaacc ctgtctctac taaaaataca aatatcagcc aggtgtgatg gcacatgcct     6720

gtaatcccag ctacttggga ggctgaggca ggagaattgc ttgaatccgg gaggtggagg     6780

ttgcagtgag ctgagatcat gccattgcat tccagcctgg gcaacagaac gagactccgt     6840

ctcaaaaaaa aaaaaattgg ttcaggatga acttgcagag cactcttcca cagaacatgg     6900

ttaggttagc cctgcctgac ttctagcaat tgctaactat acaccttgcc tgcctctagg     6960

acccctacct gagtggcaac cataccttcc atatgctctg ttccatggca gtccctgcca     7020

tcccccacca gcggactctg gctccctccc tgtacccatt tctagcaaca gctccttgcc     7080

tggctgctaa gacggaggcg cctccttgtt tgttcctggg ctctgttctg ctccctctct     7140

cactccatgg agtcacttat agtcttcctt tctgaacgcc agaattgagc ctttgctcct     7200

tctggatcac cccttcctgg gcttcttctc catccctcag tactgctaaa attgccctgc     7260

tcctttagtc catttccatg acctcagccc tctctctcct ctccttgtct tttaactttc     7320

tcctggactt cttcctctcc ccagcatgaa cccagagcct atcacacact gatgtttttg     7380

tcagcatcct gaactttctc atgcccttca actttattta tttatttatt tatttatttt     7440

ttattttttg agagagagag tctcactctg tcatgcaggc tggagtgcag tggtatgatg     7500

tcggctcatt gcaacctctg ccttctgggc tcaggtgatc ctcccatctc agcctcctga     7560

gtagctggga ctacaggtgc atgccaccat gcctggctaa tttttctact ttaggtagag     7620

atggagtttc gccatgttgc tcaagctggt atcaacactc ctgggctcaa gcagtctgct     7680

tcccttggcc tcccaaagtg ctgggattac aggcgtgagc cactgcgcca ggcgtatccc     7740

cttcaatttt gctgaaacta tcagccattc tccattttcg gcatcatcat atttgctgct     7800

tccacctcct gggctgctat gcatgacaga ttcacagttg gcagcctcag ttgagctctc     7860

agtgttgact ggaaattctt taacttgttg tgatcccttt ttttttcccc acccatgcct     7920

ccatctttgt cctccacaaa tgactgagct cactgtctac ttcacagaag acagccccta     7980

aagcaagagc ttccttgcct gctgttcctc tctcccctct cattcatctg tgtctgtaac     8040

tctccccaac ccctccattc ttgctcctat ttaattctct atatcttgaa tcctgttgta     8100

tgtcctccaa gactgctccc tcgcttactc cactgctccc actccctgga gtctccagcc     8160

tctgtctcca ctggttacct ccacacagcc tgcaaacaag ttctccacaa gattaaaaca     8220

gcatttctca gagtctgtta ccccttacac attttccttg ttaaccaagt tacttttaaa     8280

aagatccttt ttaaactgat tcttcctcag ctgttcttca gccctctata ctttttcata     8340

aaagtcacca gtgactgccc agttgccaaa tagaatgaat acctttcagt gctcagctgt     8400

cttgacctct ccgcagcatt tcacaccacc caccaaccct cagtgaaaca acctcctccc     8460

ttagctttta tgacaccaca agtctctgga ttctcagaga atccagaaaa acaagtctct     8520

ggattctctc ctcttacctc tcagcccaca caggctgagc tgtccttgaa acctagatgg     8580

gggaaatgtc tgtggctgtc tgtggtctct tcttttcagg agttgggtag ggaggaagaa     8640

tcacagctgc tcctgcttcc tctgtctgtc tctctatttc ctgagtccct tccttttcct     8700

gaactcagtt ctcctcatgc caaccatgtt tatgagctcc tgctgggagg acagcatctg     8760

tgagtccttc cctctgtctc tcccagacaa cacagaggtt ttagcctgtt tgctaagaga     8820

ccccatctaa gtcagcccaa gggtgtggat taggttttac agcatccagg ccgcagtctg     8880

gctaaactgg attaccaggc tggtgggcag ctcctcacca tgatcctgca ccagttagag     8940

cctgctgtag ttgggaagga gcctgggatt gtggtaagat gtgtttccgt gcatgtcagt     9000

gctgctaacc aggaggagaa cctggcaggg tgggtgcctg ctgctgataa cattcggatg     9060

gagggagact agggagcgcg gtggctgctc ccttgctggg gctcagctgg agtcagcatg     9120

actccttata tcagggcctt tcccacctgt gctgatcacc accacctgct tgctccagtt     9180

gtttctggag ttggaggcag ctattggttg ctttcttgga ggtaaggagg tatatactag     9240

aaagatatct gatttgagag tctgaacacc aaaatttttg gctctttcca ttatgagctg     9300

tgtaaccttg gatacagttt cctcatctat aaagttgtgg tgggagaatg gctgagaaca     9360

gtgatctctc agctctccag ctgtaaagat gttaattatg attttaactc tcaagatcag     9420

gccacataag gaacagggga attccagggg tgggacacag ctgggggagt ccagaccagg     9480

gcagggaaag gagactcaca agccaaacag agctgctttg gggaaagttc ttatcagctg     9540

gtgctgcttc ctgagccata tgcccattcc tcaagctgta cccctttctt ggctatgtag     9600

gatgagttcc tcctaggccc ttgttaggag tggctattgg attctaagcg gttggggcat     9660

gagggaggat attttaaagg gaagtatagc tgattttaaa agaacctata cattcaagaa     9720

caaataaaaa acagcacttt tctttaccaa gaa                                  9753


<210>  506
<211>  1216
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Ala Arg Asn Cys Ser Glu Cys Lys Glu Lys Arg Ala Ala His Ile 
1               5                   10                  15      


Leu Cys Thr Tyr Cys Asn Arg Trp Leu Cys Ser Ser Cys Thr Glu Glu 
            20                  25                  30          


His Arg His Ser Pro Val Pro Gly Gly Pro Phe Phe Pro Arg Ala Gln 
        35                  40                  45              


Lys Gly Ser Pro Gly Val Asn Gly Gly Pro Gly Asp Phe Thr Leu Tyr 
    50                  55                  60                  


Cys Pro Leu His Thr Gln Glu Val Leu Lys Leu Phe Cys Glu Thr Cys 
65                  70                  75                  80  


Asp Met Leu Thr Cys His Ser Cys Leu Val Val Glu His Lys Glu His 
                85                  90                  95      


Arg Cys Arg His Val Glu Glu Val Leu Gln Asn Gln Arg Met Leu Leu 
            100                 105                 110         


Glu Gly Val Thr Thr Gln Val Ala His Lys Lys Ser Ser Leu Gln Thr 
        115                 120                 125             


Ser Ala Lys Gln Ile Glu Asp Arg Ile Phe Glu Val Lys His Gln His 
    130                 135                 140                 


Arg Lys Val Glu Asn Gln Ile Lys Met Ala Lys Met Val Leu Met Asn 
145                 150                 155                 160 


Glu Leu Asn Lys Gln Ala Asn Gly Leu Ile Glu Glu Leu Glu Gly Ile 
                165                 170                 175     


Thr Asn Glu Arg Lys Arg Lys Leu Glu Gln Gln Leu Gln Ser Ile Met 
            180                 185                 190         


Val Leu Asn Arg Gln Phe Glu His Val Gln Asn Phe Ile Asn Trp Ala 
        195                 200                 205             


Val Cys Ser Lys Thr Ser Val Pro Phe Leu Phe Ser Lys Glu Leu Ile 
    210                 215                 220                 


Val Phe Gln Met Gln Arg Leu Leu Glu Thr Ser Cys Asn Thr Asp Pro 
225                 230                 235                 240 


Gly Ser Pro Trp Ser Ile Arg Phe Thr Trp Glu Pro Asn Phe Trp Thr 
                245                 250                 255     


Lys Gln Leu Ala Ser Leu Gly Cys Ile Thr Thr Glu Gly Gly Gln Met 
            260                 265                 270         


Ser Arg Ala Asp Ala Pro Ala Tyr Gly Gly Leu Gln Gly Ser Ser Pro 
        275                 280                 285             


Phe Tyr Gln Ser His Gln Ser Pro Val Ala Gln Gln Glu Ala Leu Ser 
    290                 295                 300                 


His Pro Ser His Lys Phe Gln Ser Pro Ala Val Cys Ser Ser Ser Val 
305                 310                 315                 320 


Cys Cys Ser His Cys Ser Pro Val Ser Pro Ser Leu Lys Gly Gln Val 
                325                 330                 335     


Pro Pro Pro Ser Ile His Pro Ala His Ser Phe Arg Gln Pro Pro Glu 
            340                 345                 350         


Met Val Pro Gln Gln Leu Gly Ser Leu Gln Cys Ser Ala Leu Leu Pro 
        355                 360                 365             


Arg Glu Lys Glu Leu Ala Cys Ser Pro His Pro Pro Lys Leu Leu Gln 
    370                 375                 380                 


Pro Trp Leu Glu Thr Gln Pro Pro Val Glu Gln Glu Ser Thr Ser Gln 
385                 390                 395                 400 


Arg Leu Gly Gln Gln Leu Thr Ser Gln Pro Val Cys Ile Val Pro Pro 
                405                 410                 415     


Gln Asp Val Gln Gln Gly Ala His Ala Gln Pro Thr Leu Gln Thr Pro 
            420                 425                 430         


Ser Ile Gln Val Gln Phe Gly His His Gln Lys Leu Lys Leu Ser His 
        435                 440                 445             


Phe Gln Gln Gln Pro Gln Gln Gln Leu Pro Pro Pro Pro Pro Pro Leu 
    450                 455                 460                 


Pro His Pro Pro Pro Pro Leu Pro Pro Pro Pro Gln Gln Pro His Pro 
465                 470                 475                 480 


Pro Leu Pro Pro Ser Gln His Leu Ala Ser Ser Gln His Glu Ser Pro 
                485                 490                 495     


Pro Gly Pro Ala Cys Ser Gln Asn Met Asp Ile Met His His Lys Phe 
            500                 505                 510         


Glu Leu Glu Glu Met Gln Lys Asp Leu Glu Leu Leu Leu Gln Ala Gln 
        515                 520                 525             


Gln Pro Ser Leu Gln Leu Ser Gln Thr Lys Ser Pro Gln His Leu Gln 
    530                 535                 540                 


Gln Thr Ile Val Gly Gln Ile Asn Tyr Ile Val Arg Gln Pro Ala Pro 
545                 550                 555                 560 


Val Gln Ser Gln Ser Gln Glu Glu Thr Leu Gln Ala Thr Asp Glu Pro 
                565                 570                 575     


Pro Ala Ser Gln Gly Ser Lys Pro Ala Leu Pro Leu Asp Lys Asn Thr 
            580                 585                 590         


Ala Ala Ala Leu Pro Gln Ala Ser Gly Glu Glu Thr Pro Leu Ser Val 
        595                 600                 605             


Pro Pro Val Asp Ser Thr Ile Gln His Ser Ser Pro Asn Val Val Arg 
    610                 615                 620                 


Lys His Ser Thr Ser Leu Ser Ile Met Gly Phe Ser Asn Thr Leu Glu 
625                 630                 635                 640 


Met Glu Leu Ser Ser Thr Arg Leu Glu Arg Pro Leu Glu Pro Gln Ile 
                645                 650                 655     


Gln Ser Val Ser Asn Leu Thr Ala Gly Ala Pro Gln Ala Val Pro Ser 
            660                 665                 670         


Leu Leu Ser Ala Pro Pro Lys Met Val Ser Ser Leu Thr Ser Val Gln 
        675                 680                 685             


Asn Gln Ala Met Pro Ser Leu Thr Thr Ser His Leu Gln Thr Val Pro 
    690                 695                 700                 


Ser Leu Val His Ser Thr Phe Gln Ser Met Pro Asn Leu Ile Ser Asp 
705                 710                 715                 720 


Ser Pro Gln Ala Met Ala Ser Leu Ala Ser Asp His Pro Gln Ala Gly 
                725                 730                 735     


Pro Ser Leu Met Ser Gly His Thr Gln Ala Val Pro Ser Leu Ala Thr 
            740                 745                 750         


Cys Pro Leu Gln Ser Ile Pro Pro Val Ser Asp Met Gln Pro Glu Thr 
        755                 760                 765             


Gly Ser Ser Ser Ser Ser Gly Arg Thr Ser Gly Ser Leu Cys Pro Arg 
    770                 775                 780                 


Asp Gly Ala Asp Pro Ser Leu Glu Asn Ala Leu Cys Lys Val Lys Leu 
785                 790                 795                 800 


Glu Glu Pro Ile Asn Leu Ser Val Lys Lys Pro Pro Leu Ala Pro Val 
                805                 810                 815     


Val Ser Thr Ser Thr Ala Leu Gln Gln Tyr Gln Asn Pro Lys Glu Cys 
            820                 825                 830         


Glu Asn Phe Glu Gln Gly Ala Leu Glu Leu Asp Ala Lys Glu Asn Gln 
        835                 840                 845             


Ser Ile Arg Ala Phe Asn Ser Glu His Lys Ile Pro Tyr Val Arg Leu 
    850                 855                 860                 


Glu Arg Leu Lys Ile Cys Ala Ala Ser Ser Gly Glu Met Pro Val Phe 
865                 870                 875                 880 


Lys Leu Lys Pro Gln Lys Asn Asp Gln Asp Gly Ser Phe Leu Leu Ile 
                885                 890                 895     


Ile Glu Cys Gly Thr Glu Ser Ser Ser Met Ser Ile Lys Val Ser Gln 
            900                 905                 910         


Asp Arg Leu Ser Glu Ala Thr Gln Ala Pro Gly Leu Glu Gly Arg Lys 
        915                 920                 925             


Val Thr Val Thr Ser Leu Ala Gly Gln Arg Pro Pro Glu Val Glu Gly 
    930                 935                 940                 


Thr Ser Pro Glu Glu His Arg Leu Ile Pro Arg Thr Pro Gly Ala Lys 
945                 950                 955                 960 


Lys Gly Pro Pro Ala Pro Ile Glu Asn Glu Asp Phe Cys Ala Val Cys 
                965                 970                 975     


Leu Asn Gly Gly Glu Leu Leu Cys Cys Asp Arg Cys Pro Lys Val Phe 
            980                 985                 990         


His Leu Ser Cys His Val Pro Ala  Leu Leu Ser Phe Pro  Gly Gly Glu 
        995                 1000                 1005             


Trp Val  Cys Thr Leu Cys Arg  Ser Leu Thr Gln Pro  Glu Met Glu 
    1010                 1015                 1020             


Tyr Asp  Cys Glu Asn Ala Cys  Tyr Asn Gln Pro Gly  Met Arg Ala 
    1025                 1030                 1035             


Ser Pro  Gly Leu Ser Met Tyr  Asp Gln Lys Lys Cys  Glu Lys Leu 
    1040                 1045                 1050             


Val Leu  Ser Leu Cys Cys Asn  Asn Leu Ser Leu Pro  Phe His Glu 
    1055                 1060                 1065             


Pro Val  Ser Pro Leu Ala Arg  His Tyr Tyr Gln Ile  Ile Lys Arg 
    1070                 1075                 1080             


Pro Met  Asp Leu Ser Ile Ile  Arg Arg Lys Leu Gln  Lys Lys Asp 
    1085                 1090                 1095             


Pro Ala  His Tyr Thr Thr Pro  Glu Glu Val Val Ser  Asp Val Arg 
    1100                 1105                 1110             


Leu Met  Phe Trp Asn Cys Ala  Lys Phe Asn Tyr Pro  Asp Ser Glu 
    1115                 1120                 1125             


Val Ala  Glu Ala Gly Arg Cys  Leu Glu Val Phe Phe  Glu Gly Trp 
    1130                 1135                 1140             


Leu Lys  Glu Ile Tyr Pro Glu  Lys Arg Phe Ala Gln  Pro Arg Gln 
    1145                 1150                 1155             


Glu Asp  Ser Asp Ser Glu Glu  Val Ser Ser Glu Ser  Gly Cys Ser 
    1160                 1165                 1170             


Thr Pro  Gln Gly Phe Pro Trp  Pro Pro Tyr Met Gln  Glu Gly Ile 
    1175                 1180                 1185             


Gln Pro  Lys Arg Arg Arg Arg  His Met Glu Asn Glu  Arg Ala Lys 
    1190                 1195                 1200             


Arg Met  Ser Phe Arg Leu Ala  Asn Ser Ile Ser Gln  Val 
    1205                 1210                 1215     


<210>  507
<211>  6970
<212>  DNA
<213>  Homo sapiens

<400>  507
atggctagac tctctttttg gtcccaggga gtggagctgg ctcgctctac acgctgcttc       60

tcacctgagg atatcagtgg aaaagcccca gtcctgggca caggcatggc tgtggacatg      120

ggcatgagct ttatggggct gccactagct ggccagaaac actgccctaa gagtggacag      180

atggaggcca tgggccctgg gaatagcact ggcaccccag aacaggaccc attactggga      240

gagcaattcc cccgtttggg aaaattgctg cagagccttc gagataaaca gaaacaggag      300

gagtcaacca agctctttct tgcaggagta tctcagaact gctctgagtg caaggagaag      360

agggcagcac atatcctctg cacctactgc aatcgctggc tgtgcagctc ttgcacagag      420

gaacaccgac acagccctgt ccccgggggc ccattctttc ctcgggccca gaagggatct      480

ccaggagtga atggtggtcc cggagacttc accttgtatt gtcctctaca cacacaggaa      540

gtactcaagc tattctgtga gacatgtgat atgctcactt gccatagctg cctagtggtg      600

gaacacaaag aacacagaca tgttgaagaa gttttgcaaa accagaggat gcttctggaa      660

ggtgtgacta cacaggtggc acataagaaa tccagtctac agacatctgc aaagcaaatt      720

gaggacagga tttttgaagt gaagcatcag cataggaagg tggaaaacca gatcaaaatg      780

gccaagatgg ttctgatgaa tgagctgaac aaacaggcca atgggctaat agaggaatta      840

gaggggatta ctaatgagag aaagcggaag ctggaacagc agttacagag catcatggtt      900

ctcaaccgtc agtttgagca tgtgcagaat ttcatcaact gggctgtctg cagcaaaacc      960

agtgtccctt ttcttttcag caaagagctg attgtgtttc agatgcagcg attgctggag     1020

acaagttgta acacagatcc tggctcccct tggagtatca gattcacctg ggagcctaac     1080

ttctggacca agcagctagc ttctcttggc tgcataacta ctgaaggtgg acaaatgtcc     1140

agggcagatg ctcctgctta tggaggctta caggggtcat caccctttta tcaaagccac     1200

cagtctccag tggctcagca agaggctctt agccacccct cacacaagtt ccagtctcca     1260

gcagtgtgct cctcatctgt gtgctgctcc cactgctccc cagtctcgcc ttccctcaaa     1320

ggccaggtcc ccccacccag catacaccca gcccacagct tcaggcagcc ccctgagatg     1380

gtgccccagc agctggggtc tctgcagtgc tctgccctgc tgcccaggga gaaagagctg     1440

gcctgcagcc ctcatccacc aaagctgctg cagccctggc tggaaaccca gccccccgtg     1500

gagcaggaga gcacatccca gcggctgggg cagcagctga cttcccagcc cgtgtgcatt     1560

gtccccccac aggatgttca gcaaggagcc catgcccagc ccaccttaca gacaccctct     1620

atccaagtcc agtttggcca ccaccagaag ctgaagctca gtcactttca gcagcagcca     1680

cagcagcagc taccacctcc accaccaccc ctcccccatc ccccacctcc ccttccccct     1740

cccccacagc agccacaccc acctcttcct ccatcccagc atctggcttc tagtcagcac     1800

gagagccctc ctggccctgc ctgttctcag aacatggaca taatgcatca caagtttgag     1860

ctggaggaaa tgcagaagga cttggagctt cttctccagg ctcaacagcc cagcctgcaa     1920

ctgagtcaga ccaaatctcc tcagcatctt cagcaaacca ttgtggggca gatcaactac     1980

atcgtgaggc agccagcacc tgtccagtcc cagagccagg aggagaccct gcaggctaca     2040

gatgagcccc cagcatctca gggctcaaag ccggctctcc ctcttgacaa gaatactgct     2100

gctgccttgc cccaggcgtc tggggaagaa acccctctca gtgtcccccc agtggacagc     2160

accatccagc actcctctcc aaatgtggtg agaaagcact ccacctcgct gagcatcatg     2220

ggcttttcca acactctgga gatggagttg tcatctacca ggttggagag gcccctagag     2280

ccacagatcc agagtgtgag caacctgaca gctggtgccc cccaggcagt accaagcctg     2340

ctgagtgctc cccccaaaat ggtgtccagc ctgacaagtg ttcaaaacca ggccatgccc     2400

agcctgacaa ccagtcacct acagactgtg cccagccttg tgcatagcac attccagtcc     2460

atgcccaacc tgataagtga ctcccctcag gctatggcaa gcctggcaag tgatcaccct     2520

caggctgggc ccagcctaat gtctggtcac acccaggctg tgccgagtct ggcaacttgt     2580

cctctgcaga gcatccctcc agtttctgac atgcagccag aaactgggtc cagctccagt     2640

tctggccgaa cttcagggag cctgtgtccc agagatgggg ctgatccctc cctggagaat     2700

gctctgtgta aggtaaaact ggaggagcca attaacctct ctgtgaagaa acctccactg     2760

gcgccagtgg tcagcacgtc tacagctctg cagcagtacc agaacccaaa agagtgtgag     2820

aattttgaac aaggagccct agagctggat gcaaaagaga accagagcat cagagccttc     2880

aatagtgagc ataagattcc ctatgtgcga ctggagcgac tcaagatctg tgctgcctcc     2940

tcaggagaga tgcctgtgtt caaactgaag ccacagaaga atgatcagga tgggagcttc     3000

ctgctgatca tcgagtgtgg cactgagtcc tccagcatgt ccattaaggt cagccaggac     3060

agactgtctg aggccaccca ggccccaggt ctggagggaa gaaaggtcac tgtcacttct     3120

ttggctgggc agcggccacc agaagtggag ggcacatctc ctgaagaaca cagactcatt     3180

cctcgaaccc caggagccaa gaagggcccc ccagccccaa tagagaatga ggacttctgt     3240

gctgtttgcc tcaatggcgg agagttactg tgctgtgacc gctgccccaa agtgttccac     3300

ctctcctgcc atgtgccagc cttgctcagc ttcccagggg gagagtgggt gtgtaccttg     3360

tgccgcagcc tgacccagcc cgagatggag tacgactgtg agaatgcctg ctataaccag     3420

cctggaatgc gggcatctcc tggcctaagc atgtatgacc agaagaagtg tgagaagctg     3480

gtattgtcct tgtgctgcaa taacctcagc ctgcccttcc atgaacctgt cagccccctg     3540

gcccggcatt attaccagat tatcaagagg cccatggacc tgtcaatcat ccggaggaag     3600

ctgcaaaaga aggacccagc tcactatacc accccagagg aggtggtatc agatgtgcgc     3660

ctcatgttct ggaactgtgc taagttcaat tatcctgact ccgaggttgc agaggctggc     3720

cgctgcctgg aagtgttctt tgagggctgg ttgaaggaga tctacccgga gaaacggttt     3780

gcccagccaa ggcaggagga ctcagactcc gaggaggtgt ctagtgagag tggatgttcc     3840

actccccagg gcttcccgtg gcctccctac atgcaggagg gcatccaacc caagaggcgg     3900

cgacgacata tggagaatga aagagcaaaa agaatgtcat ttcgcctggc caacagcatc     3960

tctcaggtgt gagagccaaa aggagactgg gcactctggc agctgttgtc ccatactgtc     4020

gaccattcct ccccatcttg cagcttatcc tcttcagagt gtggatggta gatgagtctt     4080

gttgaactgt gtagtgctct tctttgccat ttgcatctac agcatttatt tgggagccgt     4140

agtacatcca ctacagagaa gatttcagta ataaacagga aagaggaagg tatttattat     4200

taccagagta atcagatgta taggctccac ttgacaagac cacacctggt taggctcggg     4260

aaaacctact ttccttggtg aatttttttc tgcctgggaa agcagacccg tctaaccttt     4320

tagtgtccag ggctcaggag ccatgtatac atctgaactc ctcctgggct cagaagtggg     4380

taaaagaagg gagagaggtt tagacatatg gcaggactgt gatccctggc ccagcacagc     4440

caaagactgt cactgtttgc ctttgcttgt cctgtctgga tagaggcacc tgccatgtgc     4500

agactagtgg aggcttctag aggccatagg tctcaatttg tgcctatttg ggttctaacg     4560

gttttcaggg tatttgtttt gcatagtcac tttcctgatg ttgacatagg tggctgctgt     4620

gaaaatgctg tggatggtgt gacattcttg actgagctgg gtggctgtgg agagaccact     4680

taaatcttct ggttcagatt tcacttacag acttagtaag atgtccactt cagagcccgc     4740

cctctgtgct acttactctg ggctaatcac acttctttag ggtgagaacc tgccttccta     4800

gaagtgactg ttggtgcttg tcagtggcca tacccttcat catcctcatt cagaggtatg     4860

gatcgtgagt tctgcttgtg aatactgtga gacagctgct gtctgcttca ggtccagagt     4920

tccatgggtg gagagagtaa cccacaacca gctcactcct ctgggcctct cctcctgctt     4980

aaagattcta gttctcaacc tctccaagtt catgagccaa agatcagaag tgagtcttct     5040

gaccagcccg cctccaggct gtctacagcc ccaaaaaagc caacactttt ctggcagccc     5100

tttttgttgg aggttagaga aggcctcagg gaccaacagg ggccagatct agacattcct     5160

gggggaagtt tgtctaaggt ggacaggggg aaaaatcaag aggcaaaaag ccagtgtcct     5220

ttggtgacca tgaagcaacc tcagagcctt agttctccta gaatgcagag agaagcattc     5280

tggaagccat gggaacagga gctcgaggct gcatcctgaa tgcatctgca tggccctcgc     5340

agggtgtttg tgaggatact ggaggtcagg ctacctccca agcaagggct tggttgagaa     5400

ggaacccatt gctcatattg ttgggggagc tatgaacctg acatgtcagt ggccaggact     5460

gagacagctc tccctggtcc tgtcattgca tggctaattt caggggagtc tgaggtcatg     5520

gctttatttt tgctaacaga tgaagttcaa ggatgttctt gtttgtaggg cctttgctaa     5580

tgagcagttt tttaattaga aaacatttct tctctctttg tgagttgatg gtattgctca     5640

tttccttctc tacccaacct gagagatcat cttcacttta aagcaaacca tgccccttgg     5700

cttgccattc tttcagcagc acatgccacg ttctaagcag atgggcttcc gtgatcccgt     5760

tttctagttt ggggtaactg agtcttgaat gctttactag tccggcaatc tttggactta     5820

ggcttctgcc ctttgagact cacatgactt tctggtttgg ggtctggtca tttccctttc     5880

aatttttgaa tctccttctc tgttcagttg gcttggcaaa gtaccctctg ttctcatgtc     5940

actaattcct gctctaggtc atctttcctt tgtgcagccc acattcccac catcctgtga     6000

actttgttgt acttggtgtt gggcaactgg tgagtgttgt gacaggctca gacctgatcc     6060

ttcctcagga gcaattggag accacaaatt taaagcagaa atacctgtta aaagcttggc     6120

tttccttata tgagtgaggc tcccagcttg ggtgtggcct cctgggctca cggatcagct     6180

tgctgggcca gagggggtct tagtaatgtg ctagagagac acatgctccc ttctcatcgt     6240

agagagcctg catgctgaga ggctcccttt acacacctgc ctctcgctgg cttttccttt     6300

agacctagcc accagtgttt tgaatcatgg ttttgttttg tttttgcatg caaaaaccag     6360

aacatgactt agaaattaaa aaaaaaaaaa tcctactagc caagtgactg cctgcagagg     6420

ctcttcatta acatttgggc tgatcctgct tttgacttat tcccataatg gcccagtttt     6480

gaagtcagcc aagtcctttt gtccttgaca acatcatgca gtggaaatac ggtgagttct     6540

agattcttat gggacagcat gcagccctag aggaaaaatt gacttcttgg gtatgctgag     6600

aaataagaca gtaaaatggc ttcagttgat gcaaggggat tttagttaaa aattggttca     6660

ggatttttaa attttatttt attttttggc tgggcgcggt ggctcacgcc tgtaatccca     6720

gcactttggg aggctgaggt gggtggatca cctaaggaca gcagttcgag accagcctgg     6780

ccaacatagt gaaaccctgt ctctactaaa aatacaaata tcagccaggt gtgatggcac     6840

atgcctgtaa tcccagctac ttgggaggct gaggcaggag aattgcttga atccgggagg     6900

tggaggttgc agtgagctga gatcatgcca ttgcattcca gcctgggcaa cagaacgaga     6960

ctccgtctca                                                            6970


<210>  508
<211>  1323
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Ala Arg Leu Ser Phe Trp Ser Gln Gly Val Glu Leu Ala Arg Ser 
1               5                   10                  15      


Thr Arg Cys Phe Ser Pro Glu Asp Ile Ser Gly Lys Ala Pro Val Leu 
            20                  25                  30          


Gly Thr Gly Met Ala Val Asp Met Gly Met Ser Phe Met Gly Leu Pro 
        35                  40                  45              


Leu Ala Gly Gln Lys His Cys Pro Lys Ser Gly Gln Met Glu Ala Met 
    50                  55                  60                  


Gly Pro Gly Asn Ser Thr Gly Thr Pro Glu Gln Asp Pro Leu Leu Gly 
65                  70                  75                  80  


Glu Gln Phe Pro Arg Leu Gly Lys Leu Leu Gln Ser Leu Arg Asp Lys 
                85                  90                  95      


Gln Lys Gln Glu Glu Ser Thr Lys Leu Phe Leu Ala Gly Val Ser Gln 
            100                 105                 110         


Asn Cys Ser Glu Cys Lys Glu Lys Arg Ala Ala His Ile Leu Cys Thr 
        115                 120                 125             


Tyr Cys Asn Arg Trp Leu Cys Ser Ser Cys Thr Glu Glu His Arg His 
    130                 135                 140                 


Ser Pro Val Pro Gly Gly Pro Phe Phe Pro Arg Ala Gln Lys Gly Ser 
145                 150                 155                 160 


Pro Gly Val Asn Gly Gly Pro Gly Asp Phe Thr Leu Tyr Cys Pro Leu 
                165                 170                 175     


His Thr Gln Glu Val Leu Lys Leu Phe Cys Glu Thr Cys Asp Met Leu 
            180                 185                 190         


Thr Cys His Ser Cys Leu Val Val Glu His Lys Glu His Arg His Val 
        195                 200                 205             


Glu Glu Val Leu Gln Asn Gln Arg Met Leu Leu Glu Gly Val Thr Thr 
    210                 215                 220                 


Gln Val Ala His Lys Lys Ser Ser Leu Gln Thr Ser Ala Lys Gln Ile 
225                 230                 235                 240 


Glu Asp Arg Ile Phe Glu Val Lys His Gln His Arg Lys Val Glu Asn 
                245                 250                 255     


Gln Ile Lys Met Ala Lys Met Val Leu Met Asn Glu Leu Asn Lys Gln 
            260                 265                 270         


Ala Asn Gly Leu Ile Glu Glu Leu Glu Gly Ile Thr Asn Glu Arg Lys 
        275                 280                 285             


Arg Lys Leu Glu Gln Gln Leu Gln Ser Ile Met Val Leu Asn Arg Gln 
    290                 295                 300                 


Phe Glu His Val Gln Asn Phe Ile Asn Trp Ala Val Cys Ser Lys Thr 
305                 310                 315                 320 


Ser Val Pro Phe Leu Phe Ser Lys Glu Leu Ile Val Phe Gln Met Gln 
                325                 330                 335     


Arg Leu Leu Glu Thr Ser Cys Asn Thr Asp Pro Gly Ser Pro Trp Ser 
            340                 345                 350         


Ile Arg Phe Thr Trp Glu Pro Asn Phe Trp Thr Lys Gln Leu Ala Ser 
        355                 360                 365             


Leu Gly Cys Ile Thr Thr Glu Gly Gly Gln Met Ser Arg Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gly Gly Leu Gln Gly Ser Ser Pro Phe Tyr Gln Ser His 
385                 390                 395                 400 


Gln Ser Pro Val Ala Gln Gln Glu Ala Leu Ser His Pro Ser His Lys 
                405                 410                 415     


Phe Gln Ser Pro Ala Val Cys Ser Ser Ser Val Cys Cys Ser His Cys 
            420                 425                 430         


Ser Pro Val Ser Pro Ser Leu Lys Gly Gln Val Pro Pro Pro Ser Ile 
        435                 440                 445             


His Pro Ala His Ser Phe Arg Gln Pro Pro Glu Met Val Pro Gln Gln 
    450                 455                 460                 


Leu Gly Ser Leu Gln Cys Ser Ala Leu Leu Pro Arg Glu Lys Glu Leu 
465                 470                 475                 480 


Ala Cys Ser Pro His Pro Pro Lys Leu Leu Gln Pro Trp Leu Glu Thr 
                485                 490                 495     


Gln Pro Pro Val Glu Gln Glu Ser Thr Ser Gln Arg Leu Gly Gln Gln 
            500                 505                 510         


Leu Thr Ser Gln Pro Val Cys Ile Val Pro Pro Gln Asp Val Gln Gln 
        515                 520                 525             


Gly Ala His Ala Gln Pro Thr Leu Gln Thr Pro Ser Ile Gln Val Gln 
    530                 535                 540                 


Phe Gly His His Gln Lys Leu Lys Leu Ser His Phe Gln Gln Gln Pro 
545                 550                 555                 560 


Gln Gln Gln Leu Pro Pro Pro Pro Pro Pro Leu Pro His Pro Pro Pro 
                565                 570                 575     


Pro Leu Pro Pro Pro Pro Gln Gln Pro His Pro Pro Leu Pro Pro Ser 
            580                 585                 590         


Gln His Leu Ala Ser Ser Gln His Glu Ser Pro Pro Gly Pro Ala Cys 
        595                 600                 605             


Ser Gln Asn Met Asp Ile Met His His Lys Phe Glu Leu Glu Glu Met 
    610                 615                 620                 


Gln Lys Asp Leu Glu Leu Leu Leu Gln Ala Gln Gln Pro Ser Leu Gln 
625                 630                 635                 640 


Leu Ser Gln Thr Lys Ser Pro Gln His Leu Gln Gln Thr Ile Val Gly 
                645                 650                 655     


Gln Ile Asn Tyr Ile Val Arg Gln Pro Ala Pro Val Gln Ser Gln Ser 
            660                 665                 670         


Gln Glu Glu Thr Leu Gln Ala Thr Asp Glu Pro Pro Ala Ser Gln Gly 
        675                 680                 685             


Ser Lys Pro Ala Leu Pro Leu Asp Lys Asn Thr Ala Ala Ala Leu Pro 
    690                 695                 700                 


Gln Ala Ser Gly Glu Glu Thr Pro Leu Ser Val Pro Pro Val Asp Ser 
705                 710                 715                 720 


Thr Ile Gln His Ser Ser Pro Asn Val Val Arg Lys His Ser Thr Ser 
                725                 730                 735     


Leu Ser Ile Met Gly Phe Ser Asn Thr Leu Glu Met Glu Leu Ser Ser 
            740                 745                 750         


Thr Arg Leu Glu Arg Pro Leu Glu Pro Gln Ile Gln Ser Val Ser Asn 
        755                 760                 765             


Leu Thr Ala Gly Ala Pro Gln Ala Val Pro Ser Leu Leu Ser Ala Pro 
    770                 775                 780                 


Pro Lys Met Val Ser Ser Leu Thr Ser Val Gln Asn Gln Ala Met Pro 
785                 790                 795                 800 


Ser Leu Thr Thr Ser His Leu Gln Thr Val Pro Ser Leu Val His Ser 
                805                 810                 815     


Thr Phe Gln Ser Met Pro Asn Leu Ile Ser Asp Ser Pro Gln Ala Met 
            820                 825                 830         


Ala Ser Leu Ala Ser Asp His Pro Gln Ala Gly Pro Ser Leu Met Ser 
        835                 840                 845             


Gly His Thr Gln Ala Val Pro Ser Leu Ala Thr Cys Pro Leu Gln Ser 
    850                 855                 860                 


Ile Pro Pro Val Ser Asp Met Gln Pro Glu Thr Gly Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Gly Arg Thr Ser Gly Ser Leu Cys Pro Arg Asp Gly Ala Asp Pro 
                885                 890                 895     


Ser Leu Glu Asn Ala Leu Cys Lys Val Lys Leu Glu Glu Pro Ile Asn 
            900                 905                 910         


Leu Ser Val Lys Lys Pro Pro Leu Ala Pro Val Val Ser Thr Ser Thr 
        915                 920                 925             


Ala Leu Gln Gln Tyr Gln Asn Pro Lys Glu Cys Glu Asn Phe Glu Gln 
    930                 935                 940                 


Gly Ala Leu Glu Leu Asp Ala Lys Glu Asn Gln Ser Ile Arg Ala Phe 
945                 950                 955                 960 


Asn Ser Glu His Lys Ile Pro Tyr Val Arg Leu Glu Arg Leu Lys Ile 
                965                 970                 975     


Cys Ala Ala Ser Ser Gly Glu Met Pro Val Phe Lys Leu Lys Pro Gln 
            980                 985                 990         


Lys Asn Asp Gln Asp Gly Ser Phe  Leu Leu Ile Ile Glu  Cys Gly Thr 
        995                 1000                 1005             


Glu Ser  Ser Ser Met Ser Ile  Lys Val Ser Gln Asp  Arg Leu Ser 
    1010                 1015                 1020             


Glu Ala  Thr Gln Ala Pro Gly  Leu Glu Gly Arg Lys  Val Thr Val 
    1025                 1030                 1035             


Thr Ser  Leu Ala Gly Gln Arg  Pro Pro Glu Val Glu  Gly Thr Ser 
    1040                 1045                 1050             


Pro Glu  Glu His Arg Leu Ile  Pro Arg Thr Pro Gly  Ala Lys Lys 
    1055                 1060                 1065             


Gly Pro  Pro Ala Pro Ile Glu  Asn Glu Asp Phe Cys  Ala Val Cys 
    1070                 1075                 1080             


Leu Asn  Gly Gly Glu Leu Leu  Cys Cys Asp Arg Cys  Pro Lys Val 
    1085                 1090                 1095             


Phe His  Leu Ser Cys His Val  Pro Ala Leu Leu Ser  Phe Pro Gly 
    1100                 1105                 1110             


Gly Glu  Trp Val Cys Thr Leu  Cys Arg Ser Leu Thr  Gln Pro Glu 
    1115                 1120                 1125             


Met Glu  Tyr Asp Cys Glu Asn  Ala Cys Tyr Asn Gln  Pro Gly Met 
    1130                 1135                 1140             


Arg Ala  Ser Pro Gly Leu Ser  Met Tyr Asp Gln Lys  Lys Cys Glu 
    1145                 1150                 1155             


Lys Leu  Val Leu Ser Leu Cys  Cys Asn Asn Leu Ser  Leu Pro Phe 
    1160                 1165                 1170             


His Glu  Pro Val Ser Pro Leu  Ala Arg His Tyr Tyr  Gln Ile Ile 
    1175                 1180                 1185             


Lys Arg  Pro Met Asp Leu Ser  Ile Ile Arg Arg Lys  Leu Gln Lys 
    1190                 1195                 1200             


Lys Asp  Pro Ala His Tyr Thr  Thr Pro Glu Glu Val  Val Ser Asp 
    1205                 1210                 1215             


Val Arg  Leu Met Phe Trp Asn  Cys Ala Lys Phe Asn  Tyr Pro Asp 
    1220                 1225                 1230             


Ser Glu  Val Ala Glu Ala Gly  Arg Cys Leu Glu Val  Phe Phe Glu 
    1235                 1240                 1245             


Gly Trp  Leu Lys Glu Ile Tyr  Pro Glu Lys Arg Phe  Ala Gln Pro 
    1250                 1255                 1260             


Arg Gln  Glu Asp Ser Asp Ser  Glu Glu Val Ser Ser  Glu Ser Gly 
    1265                 1270                 1275             


Cys Ser  Thr Pro Gln Gly Phe  Pro Trp Pro Pro Tyr  Met Gln Glu 
    1280                 1285                 1290             


Gly Ile  Gln Pro Lys Arg Arg  Arg Arg His Met Glu  Asn Glu Arg 
    1295                 1300                 1305             


Ala Lys  Arg Met Ser Phe Arg  Leu Ala Asn Ser Ile  Ser Gln Val 
    1310                 1315                 1320             


<210>  509
<211>  6970
<212>  DNA
<213>  Homo sapiens

<400>  509
atggctagac tctctttttg gtcccaggga gtggagctgg ctcgctctac acgctgcttc       60

tcacctgagg atatcagtgg aaaagcccca gtcctgggca caggcatggc tgtggacatg      120

ggcatgagct ttatggggct gccactagct ggccagaaac actgccctaa gagtggacag      180

atggaggcca tgggccctgg gaatagcact ggcaccccag aacaggaccc attactggga      240

gagcaattcc cccgtttggg aaaattgctg cagagccttc gagataaaca gaaacaggag      300

gagtcaacca agctctttct tgcaggagta tctcagaact gctctgagtg caaggagaag      360

agggcagcac atatcctctg cacctactgc aatcgctggc tgtgcagctc ttgcacagag      420

gaacaccgac acagccctgt ccccgggggc ccattctttc ctcgggccca gaagggatct      480

ccaggagtga atggtggtcc cggagacttc accttgtatt gtcctctaca cacacaggaa      540

gtactcaagc tattctgtga gacatgtgat atgctcactt gccatagctg cctagtggtg      600

gaacacaaag aacacagaca tgttgaagaa gttttgcaaa accagaggat gcttctggaa      660

ggtgtgacta cacaggtggc acataagaaa tccagtctac agacatctgc aaagcaaatt      720

gaggacagga tttttgaagt gaagcatcag cataggaagg tggaaaacca gatcaaaatg      780

gccaagatgg ttctgatgaa tgagctgaac aaacaggcca atgggctaat agaggaatta      840

gaggggatta ctaatgagag aaagcggaag ctggaacagc agttacagag catcatggtt      900

ctcaaccgtc agtttgagca tgtgcagaat ttcatcaact gggctgtctg cagcaaaacc      960

agtgtccctt ttcttttcag caaagagctg attgtgtttc agatgcagcg attgctggag     1020

acaagttgta acacagatcc tggctcccct tggagtatca gattcacctg ggagcctaac     1080

ttctggacca agcagctagc ttctcttggc tgcataacta ctgaaggtgg acaaatgtcc     1140

agggcagatg ctcctgctta tggaggctta caggggtcat caccctttta tcaaagccac     1200

cagtctccag tggctcagca agaggctctt agccacccct cacacaagtt ccagtctcca     1260

gcagtgtgct cctcatctgt gtgctgctcc cgctgctccc cagtctcgcc ttccctcaaa     1320

ggccaggtcc ccccacccag catacaccca gcccacagct tcaggcagcc ccctgagatg     1380

gtgccccagc agctggggtc tctgcagtgc tctgccctgc tgcccaggga gaaagagctg     1440

gcctgcagcc ctcatccacc aaagctgctg cagccctggc tggaaaccca gccccccgtg     1500

gagcaggaga gcacatccca gcggctgggg cagcagctga cttcccagcc cgtgtgcatt     1560

gtccccccac aggatgttca gcaaggagcc catgcccagc ccaccttaca gacaccctct     1620

atccaagtcc agtttggcca ccaccagaag ctgaagctca gtcactttca gcagcagcca     1680

cagcagcagc taccacctcc accaccaccc ctcccccatc ccccacctcc ccttccccct     1740

cccccacagc agccacaccc acctcttcct ccatcccagc atctggcttc tagtcagcac     1800

gagagccctc ctggccctgc ctgttctcag aacatggaca taatgcatca caagtttgag     1860

ctggaggaaa tgcagaagga cttggagctt cttctccagg ctcaacagcc cagcctgcaa     1920

ctgagtcaga ccaaatctcc tcagcatctt cagcaaacca ttgtggggca gatcaactac     1980

atcgtgaggc agccagcacc tgtccagtcc cagagccagg aggagaccct gcaggctaca     2040

gatgagcccc cagcatctca gggctcaaag ccggctctcc ctcttgacaa gaatactgct     2100

gctgccttgc cccaggcgtc tggggaagaa acccctctca gtgtcccccc agtggacagc     2160

accatccagc actcctctcc aaatgtggtg agaaagcact ccacctcgct gagcatcatg     2220

ggcttttcca acactctgga gatggagttg tcatctacca ggttggagag gcccctagag     2280

ccacagatcc agagtgtgag caacctgaca gctggtgccc cccaggcagt accaagcctg     2340

ctgagtgctc cccccaaaat ggtgtccagc ctgacaagtg ttcaaaacca ggccatgccc     2400

agcctgacaa ccagtcacct acagactgtg cccagccttg tgcatagcac attccagtcc     2460

atgcccaacc tgataagtga ctcccctcag gctatggcaa gcctggcaag tgatcaccct     2520

caggctgggc ccagcctaat gtctggtcac acccaggctg tgccgagtct ggcaacttgt     2580

cctctgcaga gcatccctcc agtttctgac atgcagccag aaactgggtc cagctccagt     2640

tctggccgaa cttcagggag cctgtgtccc agagatgggg ctgatccctc cctggagaat     2700

gctctgtgta aggtaaaact ggaggagcca attaacctct ctgtgaagaa acctccactg     2760

gcgccagtgg tcagcacgtc tacagctctg cagcagtacc agaacccaaa agagtgtgag     2820

aattttgaac aaggagccct agagctggat gcaaaagaga accagagcat cagagccttc     2880

aatagtgagc ataagattcc ctatgtgcga ctggagcgac tcaagatctg tgctgcctcc     2940

tcaggagaga tgcctgtgtt caaactgaag ccacagaaga atgatcagga tgggagcttc     3000

ctgctgatca tcgagtgtgg cactgagtcc tccagcatgt ccattaaggt cagccaggac     3060

agactgtctg aggccaccca ggccccaggt ctggagggaa gaaaggtcac tgtcacttct     3120

ttggctgggc agcggccacc agaagtggag ggcacatctc ctgaagaaca cagactcatt     3180

cctcgaaccc caggagccaa gaagggcccc ccagccccaa tagagaatga ggacttctgt     3240

gctgtttgcc tcaatggcgg agagttactg tgctgtgacc gctgccccaa agtgttccac     3300

ctctcctgcc atgtgccagc cttgctcagc ttcccagggg gagagtgggt gtgtaccttg     3360

tgccgcagcc tgacccagcc cgagatggag tacgactgtg agaatgcctg ctataaccag     3420

cctggaatgc gggcatctcc tggcctaagc atgtatgacc agaagaagtg tgagaagctg     3480

gtattgtcct tgtgctgcaa taacctcagc ctgcccttcc atgaacctgt cagccccctg     3540

gcccggcatt attaccagat tatcaagagg cccatggacc tgtcaatcat ccggaggaag     3600

ctgcaaaaga aggacccagc tcactatacc accccagagg aggtggtatc agatgtgcgc     3660

ctcatgttct ggaactgtgc taagttcaat tatcctgact ccgaggttgc agaggctggc     3720

cgctgcctgg aagtgttctt tgagggctgg ttgaaggaga tctacccgga gaaacggttt     3780

gcccagccaa ggcaggagga ctcagactcc gaggaggtgt ctagtgagag tggatgttcc     3840

actccccagg gcttcccgtg gcctccctac atgcaggagg gcatccaacc caagaggcgg     3900

cgacgacata tggagaatga aagagcaaaa agaatgtcat ttcgcctggc caacagcatc     3960

tctcaggtgt gagagccaaa aggagactgg gcactctggc agctgttgtc ccatactgtc     4020

gaccattcct ccccatcttg cagcttatcc tcttcagagt gtggatggta gatgagtctt     4080

gttgaactgt gtagtgctct tctttgccat ttgcatctac agcatttatt tgggagccgt     4140

agtacatcca ctacagagaa gatttcagta ataaacagga aagaggaagg tatttattat     4200

taccagagta atcagatgta taggctccac ttgacaagac cacacctggt taggctcggg     4260

aaaacctact ttccttggtg aatttttttc tgcctgggaa agcagacccg tctaaccttt     4320

tagtgtccag ggctcaggag ccatgtatac atctgaactc ctcctgggct cagaagtggg     4380

taaaagaagg gagagaggtt tagacatatg gcaggactgt gatccctggc ccagcacagc     4440

caaagactgt cactgtttgc ctttgcttgt cctgtctgga tagaggcacc tgccatgtgc     4500

agactagtgg aggcttctag aggccatagg tctcaatttg tgcctatttg ggttctaacg     4560

gttttcaggg tatttgtttt gcatagtcac tttcctgatg ttgacatagg tggctgctgt     4620

gaaaatgctg tggatggtgt gacattcttg actgagctgg gtggctgtgg agagaccact     4680

taaatcttct ggttcagatt tcacttacag acttagtaag atgtccactt cagagcccgc     4740

cctctgtgct acttactctg ggctaatcac acttctttag ggtgagaacc tgccttccta     4800

gaagtgactg ttggtgcttg tcagtggcca tacccttcat catcctcatt cagaggtatg     4860

gatcgtgagt tctgcttgtg aatactgtga gacagctgct gtctgcttca ggtccagagt     4920

tccatgggtg gagagagtaa cccacaacca gctcactcct ctgggcctct cctcctgctt     4980

aaagattcta gttctcaacc tctccaagtt catgagccaa agatcagaag tgagtcttct     5040

gaccagcccg cctccaggct gtctacagcc ccaaaaaagc caacactttt ctggcagccc     5100

tttttgttgg aggttagaga aggcctcagg gaccaacagg ggccagatct agacattcct     5160

gggggaagtt tgtctaaggt ggacaggggg aaaaatcaag aggcaaaaag ccagtgtcct     5220

ttggtgacca tgaagcaacc tcagagcctt agttctccta gaatgcagag agaagcattc     5280

tggaagccat gggaacagga gctcgaggct gcatcctgaa tgcatctgca tggccctcgc     5340

agggtgtttg tgaggatact ggaggtcagg ctacctccca agcaagggct tggttgagaa     5400

ggaacccatt gctcatattg ttgggggagc tatgaacctg acatgtcagt ggccaggact     5460

gagacagctc tccctggtcc tgtcattgca tggctaattt caggggagtc tgaggtcatg     5520

gctttatttt tgctaagaga tgaagttcaa ggatgttctt gtttgtaggg cctttgctaa     5580

tgagcagttt tttaattaga aaacatttct tctctctttg tgagttgatg gtattgctca     5640

tttccttctc tacccaacct gagagatcat cttcacttta aagcaaacca tgccccttgg     5700

cttgccattc tttcagcagc acatgccacg ttctaagcag atgggcttcc gtgatcccgt     5760

tttctagttt ggggtaactg agtcttgaat gctttactag tccggcaatc tttggactta     5820

ggcttctgcc ctttgagact cacatgactt tctggtttgg ggtctggtca tttccctttc     5880

aatttttgaa tctccttctc tgttcagttg gcttggcaaa gtaccctctg ttctcatgtc     5940

actaattcct gctctaggtc atctttcctt tgtgcagccc acattcccac catcctgtga     6000

actttgttgt acttggtgtt gggcaactgg tgagtgttgt gacaggctca gacctgatcc     6060

ttcctcagga gcaattggag accacaaatt taaagcagaa atacctgtta aaagcttggc     6120

tttccttata tgagtgaggc tcccagcttg ggtgtggcct cctgggctca cggatcagct     6180

tgctgggcca gagggggtct tagtaatgtg ctagagagac acatgctccc ttctcatcgt     6240

agagagcctg catgctgaga ggctcccttt acacacctgc ctctcgctgg cttttccttt     6300

agacctagcc accagtgttt tgaatcatgg ttttgttttg tttttgcatg caaaaaccag     6360

aacatgactt agaaattaaa aaaaaaaaaa tcctactagc caagtgactg cctgcagagg     6420

ctcttcatta acatttgggc tgatcctgct tttgacttat tcccataatg gcccagtttt     6480

gaagtcagcc aagtcctttt gtccttgaca acatcatgca gtggaaatac ggtgagttct     6540

agattcttat gggacagcat gcagccctag aggaaaaatt gacttcttgg gtatgctgag     6600

aaataagaca gtaaaatggc ttcagttgat gcaaggggat tttagttaaa aattggttca     6660

ggatttttaa attttatttt attttttggc tgggcgcggt ggctcacgcc tgtaatccca     6720

gcactttggg aggctgaggt gggtggatca cctaaggaca gcagttcgag accagcctgg     6780

ccaacatagt gaaaccctgt ctctactaaa aatacaaata tcagccaggt gtgatggcac     6840

atgcctgtaa tcccagctac ttgggaggct gaggcaggag aattgcttga atccgggagg     6900

tggaggttgc agtgagctga gatcatgcca ttgcattcca gcctgggcaa cagaacgaga     6960

ctccgtctca                                                            6970


<210>  510
<211>  1323
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Ala Arg Leu Ser Phe Trp Ser Gln Gly Val Glu Leu Ala Arg Ser 
1               5                   10                  15      


Thr Arg Cys Phe Ser Pro Glu Asp Ile Ser Gly Lys Ala Pro Val Leu 
            20                  25                  30          


Gly Thr Gly Met Ala Val Asp Met Gly Met Ser Phe Met Gly Leu Pro 
        35                  40                  45              


Leu Ala Gly Gln Lys His Cys Pro Lys Ser Gly Gln Met Glu Ala Met 
    50                  55                  60                  


Gly Pro Gly Asn Ser Thr Gly Thr Pro Glu Gln Asp Pro Leu Leu Gly 
65                  70                  75                  80  


Glu Gln Phe Pro Arg Leu Gly Lys Leu Leu Gln Ser Leu Arg Asp Lys 
                85                  90                  95      


Gln Lys Gln Glu Glu Ser Thr Lys Leu Phe Leu Ala Gly Val Ser Gln 
            100                 105                 110         


Asn Cys Ser Glu Cys Lys Glu Lys Arg Ala Ala His Ile Leu Cys Thr 
        115                 120                 125             


Tyr Cys Asn Arg Trp Leu Cys Ser Ser Cys Thr Glu Glu His Arg His 
    130                 135                 140                 


Ser Pro Val Pro Gly Gly Pro Phe Phe Pro Arg Ala Gln Lys Gly Ser 
145                 150                 155                 160 


Pro Gly Val Asn Gly Gly Pro Gly Asp Phe Thr Leu Tyr Cys Pro Leu 
                165                 170                 175     


His Thr Gln Glu Val Leu Lys Leu Phe Cys Glu Thr Cys Asp Met Leu 
            180                 185                 190         


Thr Cys His Ser Cys Leu Val Val Glu His Lys Glu His Arg His Val 
        195                 200                 205             


Glu Glu Val Leu Gln Asn Gln Arg Met Leu Leu Glu Gly Val Thr Thr 
    210                 215                 220                 


Gln Val Ala His Lys Lys Ser Ser Leu Gln Thr Ser Ala Lys Gln Ile 
225                 230                 235                 240 


Glu Asp Arg Ile Phe Glu Val Lys His Gln His Arg Lys Val Glu Asn 
                245                 250                 255     


Gln Ile Lys Met Ala Lys Met Val Leu Met Asn Glu Leu Asn Lys Gln 
            260                 265                 270         


Ala Asn Gly Leu Ile Glu Glu Leu Glu Gly Ile Thr Asn Glu Arg Lys 
        275                 280                 285             


Arg Lys Leu Glu Gln Gln Leu Gln Ser Ile Met Val Leu Asn Arg Gln 
    290                 295                 300                 


Phe Glu His Val Gln Asn Phe Ile Asn Trp Ala Val Cys Ser Lys Thr 
305                 310                 315                 320 


Ser Val Pro Phe Leu Phe Ser Lys Glu Leu Ile Val Phe Gln Met Gln 
                325                 330                 335     


Arg Leu Leu Glu Thr Ser Cys Asn Thr Asp Pro Gly Ser Pro Trp Ser 
            340                 345                 350         


Ile Arg Phe Thr Trp Glu Pro Asn Phe Trp Thr Lys Gln Leu Ala Ser 
        355                 360                 365             


Leu Gly Cys Ile Thr Thr Glu Gly Gly Gln Met Ser Arg Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gly Gly Leu Gln Gly Ser Ser Pro Phe Tyr Gln Ser His 
385                 390                 395                 400 


Gln Ser Pro Val Ala Gln Gln Glu Ala Leu Ser His Pro Ser His Lys 
                405                 410                 415     


Phe Gln Ser Pro Ala Val Cys Ser Ser Ser Val Cys Cys Ser Arg Cys 
            420                 425                 430         


Ser Pro Val Ser Pro Ser Leu Lys Gly Gln Val Pro Pro Pro Ser Ile 
        435                 440                 445             


His Pro Ala His Ser Phe Arg Gln Pro Pro Glu Met Val Pro Gln Gln 
    450                 455                 460                 


Leu Gly Ser Leu Gln Cys Ser Ala Leu Leu Pro Arg Glu Lys Glu Leu 
465                 470                 475                 480 


Ala Cys Ser Pro His Pro Pro Lys Leu Leu Gln Pro Trp Leu Glu Thr 
                485                 490                 495     


Gln Pro Pro Val Glu Gln Glu Ser Thr Ser Gln Arg Leu Gly Gln Gln 
            500                 505                 510         


Leu Thr Ser Gln Pro Val Cys Ile Val Pro Pro Gln Asp Val Gln Gln 
        515                 520                 525             


Gly Ala His Ala Gln Pro Thr Leu Gln Thr Pro Ser Ile Gln Val Gln 
    530                 535                 540                 


Phe Gly His His Gln Lys Leu Lys Leu Ser His Phe Gln Gln Gln Pro 
545                 550                 555                 560 


Gln Gln Gln Leu Pro Pro Pro Pro Pro Pro Leu Pro His Pro Pro Pro 
                565                 570                 575     


Pro Leu Pro Pro Pro Pro Gln Gln Pro His Pro Pro Leu Pro Pro Ser 
            580                 585                 590         


Gln His Leu Ala Ser Ser Gln His Glu Ser Pro Pro Gly Pro Ala Cys 
        595                 600                 605             


Ser Gln Asn Met Asp Ile Met His His Lys Phe Glu Leu Glu Glu Met 
    610                 615                 620                 


Gln Lys Asp Leu Glu Leu Leu Leu Gln Ala Gln Gln Pro Ser Leu Gln 
625                 630                 635                 640 


Leu Ser Gln Thr Lys Ser Pro Gln His Leu Gln Gln Thr Ile Val Gly 
                645                 650                 655     


Gln Ile Asn Tyr Ile Val Arg Gln Pro Ala Pro Val Gln Ser Gln Ser 
            660                 665                 670         


Gln Glu Glu Thr Leu Gln Ala Thr Asp Glu Pro Pro Ala Ser Gln Gly 
        675                 680                 685             


Ser Lys Pro Ala Leu Pro Leu Asp Lys Asn Thr Ala Ala Ala Leu Pro 
    690                 695                 700                 


Gln Ala Ser Gly Glu Glu Thr Pro Leu Ser Val Pro Pro Val Asp Ser 
705                 710                 715                 720 


Thr Ile Gln His Ser Ser Pro Asn Val Val Arg Lys His Ser Thr Ser 
                725                 730                 735     


Leu Ser Ile Met Gly Phe Ser Asn Thr Leu Glu Met Glu Leu Ser Ser 
            740                 745                 750         


Thr Arg Leu Glu Arg Pro Leu Glu Pro Gln Ile Gln Ser Val Ser Asn 
        755                 760                 765             


Leu Thr Ala Gly Ala Pro Gln Ala Val Pro Ser Leu Leu Ser Ala Pro 
    770                 775                 780                 


Pro Lys Met Val Ser Ser Leu Thr Ser Val Gln Asn Gln Ala Met Pro 
785                 790                 795                 800 


Ser Leu Thr Thr Ser His Leu Gln Thr Val Pro Ser Leu Val His Ser 
                805                 810                 815     


Thr Phe Gln Ser Met Pro Asn Leu Ile Ser Asp Ser Pro Gln Ala Met 
            820                 825                 830         


Ala Ser Leu Ala Ser Asp His Pro Gln Ala Gly Pro Ser Leu Met Ser 
        835                 840                 845             


Gly His Thr Gln Ala Val Pro Ser Leu Ala Thr Cys Pro Leu Gln Ser 
    850                 855                 860                 


Ile Pro Pro Val Ser Asp Met Gln Pro Glu Thr Gly Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Gly Arg Thr Ser Gly Ser Leu Cys Pro Arg Asp Gly Ala Asp Pro 
                885                 890                 895     


Ser Leu Glu Asn Ala Leu Cys Lys Val Lys Leu Glu Glu Pro Ile Asn 
            900                 905                 910         


Leu Ser Val Lys Lys Pro Pro Leu Ala Pro Val Val Ser Thr Ser Thr 
        915                 920                 925             


Ala Leu Gln Gln Tyr Gln Asn Pro Lys Glu Cys Glu Asn Phe Glu Gln 
    930                 935                 940                 


Gly Ala Leu Glu Leu Asp Ala Lys Glu Asn Gln Ser Ile Arg Ala Phe 
945                 950                 955                 960 


Asn Ser Glu His Lys Ile Pro Tyr Val Arg Leu Glu Arg Leu Lys Ile 
                965                 970                 975     


Cys Ala Ala Ser Ser Gly Glu Met Pro Val Phe Lys Leu Lys Pro Gln 
            980                 985                 990         


Lys Asn Asp Gln Asp Gly Ser Phe  Leu Leu Ile Ile Glu  Cys Gly Thr 
        995                 1000                 1005             


Glu Ser  Ser Ser Met Ser Ile  Lys Val Ser Gln Asp  Arg Leu Ser 
    1010                 1015                 1020             


Glu Ala  Thr Gln Ala Pro Gly  Leu Glu Gly Arg Lys  Val Thr Val 
    1025                 1030                 1035             


Thr Ser  Leu Ala Gly Gln Arg  Pro Pro Glu Val Glu  Gly Thr Ser 
    1040                 1045                 1050             


Pro Glu  Glu His Arg Leu Ile  Pro Arg Thr Pro Gly  Ala Lys Lys 
    1055                 1060                 1065             


Gly Pro  Pro Ala Pro Ile Glu  Asn Glu Asp Phe Cys  Ala Val Cys 
    1070                 1075                 1080             


Leu Asn  Gly Gly Glu Leu Leu  Cys Cys Asp Arg Cys  Pro Lys Val 
    1085                 1090                 1095             


Phe His  Leu Ser Cys His Val  Pro Ala Leu Leu Ser  Phe Pro Gly 
    1100                 1105                 1110             


Gly Glu  Trp Val Cys Thr Leu  Cys Arg Ser Leu Thr  Gln Pro Glu 
    1115                 1120                 1125             


Met Glu  Tyr Asp Cys Glu Asn  Ala Cys Tyr Asn Gln  Pro Gly Met 
    1130                 1135                 1140             


Arg Ala  Ser Pro Gly Leu Ser  Met Tyr Asp Gln Lys  Lys Cys Glu 
    1145                 1150                 1155             


Lys Leu  Val Leu Ser Leu Cys  Cys Asn Asn Leu Ser  Leu Pro Phe 
    1160                 1165                 1170             


His Glu  Pro Val Ser Pro Leu  Ala Arg His Tyr Tyr  Gln Ile Ile 
    1175                 1180                 1185             


Lys Arg  Pro Met Asp Leu Ser  Ile Ile Arg Arg Lys  Leu Gln Lys 
    1190                 1195                 1200             


Lys Asp  Pro Ala His Tyr Thr  Thr Pro Glu Glu Val  Val Ser Asp 
    1205                 1210                 1215             


Val Arg  Leu Met Phe Trp Asn  Cys Ala Lys Phe Asn  Tyr Pro Asp 
    1220                 1225                 1230             


Ser Glu  Val Ala Glu Ala Gly  Arg Cys Leu Glu Val  Phe Phe Glu 
    1235                 1240                 1245             


Gly Trp  Leu Lys Glu Ile Tyr  Pro Glu Lys Arg Phe  Ala Gln Pro 
    1250                 1255                 1260             


Arg Gln  Glu Asp Ser Asp Ser  Glu Glu Val Ser Ser  Glu Ser Gly 
    1265                 1270                 1275             


Cys Ser  Thr Pro Gln Gly Phe  Pro Trp Pro Pro Tyr  Met Gln Glu 
    1280                 1285                 1290             


Gly Ile  Gln Pro Lys Arg Arg  Arg Arg His Met Glu  Asn Glu Arg 
    1295                 1300                 1305             


Ala Lys  Arg Met Ser Phe Arg  Leu Ala Asn Ser Ile  Ser Gln Val 
    1310                 1315                 1320             


<210>  511
<211>  6814
<212>  DNA
<213>  Homo sapiens

<400>  511
atgtgtgtct tctccatccg aagtcctaat cctctgcttg tgacggacaa ttggtcacta       60

tggcaactga ctgtgacgtc acaggataag gacttcagtt tgggaaaatt gctgcagagc      120

cttcgagata aacagaaaca ggaggagtca accaagctct ttcttgcagg agtatctcag      180

aactgctctg agtgcaagga gaagagggca gcacatatcc tctgcaccta ctgcaatcgc      240

tggctgtgca gctcttgcac agaggaacac cgacacagcc ctgtccccgg gggcccattc      300

tttcctcggg cccagaaggg atctccagga gtgaatggtg gtcccggaga cttcaccttg      360

tattgtcctc tacacacaca ggaagtactc aagctattct gtgagacatg tgatatgctc      420

acttgccata gctgcctagt ggtggaacac aaagaacaca gacatgttga agaagttttg      480

caaaaccaga ggatgcttct ggaaggtgtg actacacagg tggcacataa gaaatccagt      540

ctacagacat ctgcaaagca aattgaggac aggatttttg aagtgaagca tcagcatagg      600

aaggtggaaa accagatcaa aatggccaag atggttctga tgaatgagct gaacaaacag      660

gccaatgggc taatagagga attagagggg attactaatg agagaaagcg gaagctggaa      720

cagcagttac agagcatcat ggttctcaac cgtcagtttg agcatgtgca gaatttcatc      780

aactgggctg tctgcagcaa aaccagtgtc ccttttcttt tcagcaaaga gctgattgtg      840

tttcagatgc agcgattgct ggagacaagt tgtaacacag atcctggctc cccttggagt      900

atcagattca cctgggagcc taacttctgg accaagcagc tagcttctct tggctgcata      960

actactgaag gtggacaaat gtccagggca gatgctcctg cttatggagg cttacagggg     1020

tcatcaccct tttatcaaag ccaccagtct ccagtggctc agcaagaggc tcttagccac     1080

ccctcacaca agttccagtc tccagcagtg tgctcctcat ctgtgtgctg ctcccgctgc     1140

tccccagtct cgccttccct caaaggccag gtccccccac ccagcataca cccagcccac     1200

agcttcaggc agccccctga gatggtgccc cagcagctgg ggtctctgca gtgctctgcc     1260

ctgctgccca gggagaaaga gctggcctgc agccctcatc caccaaagct gctgcagccc     1320

tggctggaaa cccagccccc cgtggagcag gagagcacat cccagcggct ggggcagcag     1380

ctgacttccc agcccgtgtg cattgtcccc ccacaggatg ttcagcaagg agcccatgcc     1440

cagcccacct tacagacacc ctctatccaa gtccagtttg gccaccacca gaagctgaag     1500

ctcagtcact ttcagcagca gccacagcag cagctaccac ctccaccacc acccctcccc     1560

cgtcccccac ctccccttcc ccctccccca cagcagccac acccacctct tcctccatcc     1620

cagcatctgg cttctagtca gcacgagagc cctcctggcc ctgcctgttc tcagaacatg     1680

gacataatgc atcacaagtt tgagctggag gaaatgcaga aggacttgga gcttcttctc     1740

caggctcaac agcccagcct gcaactgagt cagaccaaat ctcctcagca tcttcagcaa     1800

accattgtgg ggcagatcaa ctacatcgtg aggcagccag cacctgtcca gtcccagagc     1860

caggaggaga ccctgcaggc tacagatgag cccccagcat ctcagggctc aaagccggct     1920

ctccctcttg acaagaatac tgctgctgcc ttgccccagg cgtctgggga agaaacccct     1980

ctcagtgtcc ccccagtgga cagcaccatc cagcactcct ctccaaatgt ggtgagaaag     2040

cactccacct cggtgagcat catgggcttt tccaacactc tggagatgga gttgtcatct     2100

accaggttgg agaggcccct agagccacag atccagagtg tgagccacct gacagctggt     2160

gccccccagg cagtaccaag cctgctgagt gctcccccca aaatggtgtc cagcctgaca     2220

agtgttcaaa accaggccat gcccagcctg acaaccagtc acctacagac tgtgcccagc     2280

cttgtgcata gcacattcca gtccatgccc aacctgataa gtgactcccc tcaggctatg     2340

gcaagcctgg caagtgatca ccctcaggct gggcccagcc taatgtctgg tcacacccag     2400

gctgtgccga gtctggcaac ttgtcctctg cagagcatcc ctccagtttc tgacatgcag     2460

ccagaaactg ggtccagctc cagttctggc cgaacttcag ggagcctgtg tcccagagat     2520

ggggctgatc cctccctgga gaatgctctg tgtaaggtaa aactggagga gccaattaac     2580

ctctctgtga agaaacctcc actggcgcca gtggtcagca cgtctacagc tctgcagcag     2640

taccagaacc caaaagagtg tgagaatttt gaacaaggag ccctagagct ggatgcaaaa     2700

gagaaccaga gcatcagagc cttcaatagt gagcataaga ttccctatgt gcgactggag     2760

cgactcaaga tctgtgctgc ctcctcagga gagatgcctg tgttcaaact gaagccacag     2820

aagaatgatc aggatgggag cttcctgctg atcatcgagt gtggcactga gtcctccagc     2880

atgtccatta aggtcagcca ggacagactg tctgaggcca cccaggcccc aggtctggag     2940

ggaagaaagg tcactgtcac ttctttggct gggcagcggc caccagaagt ggagggcaca     3000

tctcctgaag aacacagact cattcctcga accccaggag ccaagaaggg ccccccagcc     3060

ccaatagaga atgaggactt ctgtgctgtt tgcctcaatg gcggagagtt actgtgctgt     3120

gaccgctgcc ccaaagtgtt ccacctctcc tgccatgtgc cagccttgct cagcttccca     3180

gggggagagt gggtgtgtac cttgtgccgc agcctgaccc agcccgagat ggagtacgac     3240

tgtgagaatg cctgctataa ccagcctgga atgcgggcat ctcctggcct aagcatgtat     3300

gaccagaaga agtgtgagaa gctggtattg tccttgtgct gcaataacct cagcctgccc     3360

ttccatgaac ctgtcagccc cctggcccgg cattattacc agattatcaa gaggcccatg     3420

gacctgtcaa tcatccggag gaagctgcaa aagaaggacc cagctcacta taccacccca     3480

gaggaggtgg tatcagatgt gcgcctcatg ttctggaact gtgctaagtt caattatcct     3540

gactccgagg ttgcagaggc tggccgctgc ctggaagtgt tctttgaggg ctggttgaag     3600

gagatctacc cggagaaacg gtttgcccag ccaaggcagg aggactcaga ctccgaggag     3660

gtgtctagtg agagtggatg ttccactccc cagggcttcc cgtggcctcc ctacatgcag     3720

gagggcatcc aacccaagag gcggcgacga catatggaga atgaaagagc aaaaagaatg     3780

tcatttcgcc tggccaacag catctctcag gtgtgagagc caaaaggaga ctgggcactc     3840

tggcagctgt tgtcccatac tgtcgaccat tcctccccat cttgcagctt atcctcttca     3900

gagtgtggat ggtagatgag tcttgttgaa ctgtgtagtg ctcttctttg ccatttgcat     3960

ctacagcatt tatttgggag ctgtagtaca tccactacag agaagatttc agtaataaac     4020

aggaaagagg aaggtattta ttattaccag agtaatcaga tgtataggct ccacttgaca     4080

agaccacacc tggttaggct cgggaagacc tactttcctt ggtgaatttt tttctgcctg     4140

ggaaagcaga cccgtctaac cttttagtgt ccagggctca ggagccatgt atacatctga     4200

actcctcctg ggctcagaag tgggtaaaag aagggagaga ggtttagaca tatggcagga     4260

ctgtgatccc tggcccagca cagccaaaga ctgtcactgt ttgcctttgc ttgtcctgtc     4320

tggatagagg cacctgccat gtgcagacta gtggaggctt ctagaggcca taggtctcaa     4380

tttgtgccta tttgggttct aacggttttc agggtatttg ttttgcatag tcactttcct     4440

gatgttgaca taggtggctg ctgtgaaaat gctgtggatg gtgtgacatt cttgactgag     4500

ctgggtggct gtggagagac cacttaaatc ttctggttca gatttcactt acagacttag     4560

taagatgtcc acttcagagc ccgccctctg tgctacttac tctgggctaa tcacacttct     4620

ttagggtgag aacctgcctt cctagaagtg actgttggtg cttgtcagtg gccataccct     4680

tcatcatcct cattcagagg tatggatcgt gagttctgct tgtgaatact gtgagacagc     4740

tgctgtctgc ttcaggtcca gagttccatg ggtggagaga gtaacccaca accagctcac     4800

tcctctgggc ctctcctcct gcttaaagat tctagttctc aacctctcca agttcatgag     4860

ccaaagatca gaagtgagtc ttctgaccag cccgcctcca ggctgtctac agccccaaaa     4920

aagccaacac ttttctggca gccctttttg ttggaggtta gagaaggcct cagggaccaa     4980

caggggccag atctagacat tcctggggga agtttgtcta aggtggacag ggggaaaaat     5040

caagaggcaa aaagccagtg tcctttggtg accatgaagc aacctcagag ccttagttct     5100

cctagaatgc agagagaagc attctggaag ccatgggaac aggagctcga ggctgcatcc     5160

tgaatgcatc tgcatggccc tcgcagggtg tttgtgagga tactggaggt caggctacct     5220

cccaagcaag ggcttggttg agaaggaacc cattgctcat attgttgggg gagctatgaa     5280

cctgacatgt cagtggccag gactgagaca gctctccctg gtcctgtcat tgcatggcta     5340

atttcagggg agtctgaggt catggcttta tttttgctaa gagatgaagt tcaaggatgt     5400

tcttgtttgt agggcctttg ctaatgagca gttttttaat tagaaaacat ttcttctctc     5460

tttgtgagtt gatggtattg ctcatttcct tctctaccca acctgagaga tcatcttcac     5520

tttaaagcaa accatgcccc ttggcttgcc attctttcag cagcacatgc cacgttctaa     5580

gcagatgggc ttccgtgatc ccgttttcta gtttggggta actgagtctt gaatgcttta     5640

ctagtccggc aatctttgga cttaggcttc tgccctttga gactcacatg actttctggt     5700

ttggggtctg gtcatttccc tttcaatttt tgaatctcct tctctgttca gttggcttgg     5760

caaagtaccc tctgttctca tgtcactaat tcctgctcta ggtcatcttt cctttgtgca     5820

gcccacattc ccaccatcct gtgaactttg ttgtacttgg tgttgggcaa ctggtgagtg     5880

ttgtgacagg ctcagacctg atccttcctc aggagcaatt ggagaccaca aatttaaagc     5940

agaaatacct gttaaaagct tggctttcct tatatgagtg aggctcccag cttgggtgtg     6000

gcctcctggg ctcacggatc agcttgctgg gccagagggg gtcttagtaa tgtgctagag     6060

agacacatgc tcccttctca tcgtagagag cctgcatgct gagaggctcc ctttagacac     6120

ctgcctctcg ctggcttttc ctttagacct agccaccagt gttttgaatc atggttttgt     6180

tttgtttttg catgcaaaaa ccagaacatg acttagaaat taaaaaaaaa aaaatcctac     6240

tagccaagtg actgcctgca gaggctcttc attaacattt gggctgatcc tgcttttgac     6300

ttattcccat aatggcccag ttttgaagtc agccaagtcc ttttgtcctt gacaacatca     6360

tgcagtggaa atacggtgag ttctagattc ttatgggaca gcatgcagcc ctagaggaaa     6420

aattgacttc ttgggtatgc tgagaaataa gacagtaaaa tggcttcagt tgatgcaagg     6480

ggattttagt taaaaattgg ttcaggattt ttaaatttta ttttattttt tggctgggcg     6540

cggtggctca cgcctgtaat cccagcactt tgggaggctg aggtgggtgg atcacctaag     6600

gacagcagtt cgagaccagc ctggccaaca tagtgaaacc ctgtctctac taaaaataca     6660

aatatcagcc aggtgtgatg gcacatgcct gtaatcccag ctacttggga ggctgaggca     6720

ggagaattgc ttgaatccgg gaggtggagg ttgcagtgag ctgagatcat gccattgcat     6780

tccagcctgg gcaacagaac gagactccgt ctca                                 6814


<210>  512
<211>  1271
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Cys Val Phe Ser Ile Arg Ser Pro Asn Pro Leu Leu Val Thr Asp 
1               5                   10                  15      


Asn Trp Ser Leu Trp Gln Leu Thr Val Thr Ser Gln Asp Lys Asp Phe 
            20                  25                  30          


Ser Leu Gly Lys Leu Leu Gln Ser Leu Arg Asp Lys Gln Lys Gln Glu 
        35                  40                  45              


Glu Ser Thr Lys Leu Phe Leu Ala Gly Val Ser Gln Asn Cys Ser Glu 
    50                  55                  60                  


Cys Lys Glu Lys Arg Ala Ala His Ile Leu Cys Thr Tyr Cys Asn Arg 
65                  70                  75                  80  


Trp Leu Cys Ser Ser Cys Thr Glu Glu His Arg His Ser Pro Val Pro 
                85                  90                  95      


Gly Gly Pro Phe Phe Pro Arg Ala Gln Lys Gly Ser Pro Gly Val Asn 
            100                 105                 110         


Gly Gly Pro Gly Asp Phe Thr Leu Tyr Cys Pro Leu His Thr Gln Glu 
        115                 120                 125             


Val Leu Lys Leu Phe Cys Glu Thr Cys Asp Met Leu Thr Cys His Ser 
    130                 135                 140                 


Cys Leu Val Val Glu His Lys Glu His Arg His Val Glu Glu Val Leu 
145                 150                 155                 160 


Gln Asn Gln Arg Met Leu Leu Glu Gly Val Thr Thr Gln Val Ala His 
                165                 170                 175     


Lys Lys Ser Ser Leu Gln Thr Ser Ala Lys Gln Ile Glu Asp Arg Ile 
            180                 185                 190         


Phe Glu Val Lys His Gln His Arg Lys Val Glu Asn Gln Ile Lys Met 
        195                 200                 205             


Ala Lys Met Val Leu Met Asn Glu Leu Asn Lys Gln Ala Asn Gly Leu 
    210                 215                 220                 


Ile Glu Glu Leu Glu Gly Ile Thr Asn Glu Arg Lys Arg Lys Leu Glu 
225                 230                 235                 240 


Gln Gln Leu Gln Ser Ile Met Val Leu Asn Arg Gln Phe Glu His Val 
                245                 250                 255     


Gln Asn Phe Ile Asn Trp Ala Val Cys Ser Lys Thr Ser Val Pro Phe 
            260                 265                 270         


Leu Phe Ser Lys Glu Leu Ile Val Phe Gln Met Gln Arg Leu Leu Glu 
        275                 280                 285             


Thr Ser Cys Asn Thr Asp Pro Gly Ser Pro Trp Ser Ile Arg Phe Thr 
    290                 295                 300                 


Trp Glu Pro Asn Phe Trp Thr Lys Gln Leu Ala Ser Leu Gly Cys Ile 
305                 310                 315                 320 


Thr Thr Glu Gly Gly Gln Met Ser Arg Ala Asp Ala Pro Ala Tyr Gly 
                325                 330                 335     


Gly Leu Gln Gly Ser Ser Pro Phe Tyr Gln Ser His Gln Ser Pro Val 
            340                 345                 350         


Ala Gln Gln Glu Ala Leu Ser His Pro Ser His Lys Phe Gln Ser Pro 
        355                 360                 365             


Ala Val Cys Ser Ser Ser Val Cys Cys Ser Arg Cys Ser Pro Val Ser 
    370                 375                 380                 


Pro Ser Leu Lys Gly Gln Val Pro Pro Pro Ser Ile His Pro Ala His 
385                 390                 395                 400 


Ser Phe Arg Gln Pro Pro Glu Met Val Pro Gln Gln Leu Gly Ser Leu 
                405                 410                 415     


Gln Cys Ser Ala Leu Leu Pro Arg Glu Lys Glu Leu Ala Cys Ser Pro 
            420                 425                 430         


His Pro Pro Lys Leu Leu Gln Pro Trp Leu Glu Thr Gln Pro Pro Val 
        435                 440                 445             


Glu Gln Glu Ser Thr Ser Gln Arg Leu Gly Gln Gln Leu Thr Ser Gln 
    450                 455                 460                 


Pro Val Cys Ile Val Pro Pro Gln Asp Val Gln Gln Gly Ala His Ala 
465                 470                 475                 480 


Gln Pro Thr Leu Gln Thr Pro Ser Ile Gln Val Gln Phe Gly His His 
                485                 490                 495     


Gln Lys Leu Lys Leu Ser His Phe Gln Gln Gln Pro Gln Gln Gln Leu 
            500                 505                 510         


Pro Pro Pro Pro Pro Pro Leu Pro Arg Pro Pro Pro Pro Leu Pro Pro 
        515                 520                 525             


Pro Pro Gln Gln Pro His Pro Pro Leu Pro Pro Ser Gln His Leu Ala 
    530                 535                 540                 


Ser Ser Gln His Glu Ser Pro Pro Gly Pro Ala Cys Ser Gln Asn Met 
545                 550                 555                 560 


Asp Ile Met His His Lys Phe Glu Leu Glu Glu Met Gln Lys Asp Leu 
                565                 570                 575     


Glu Leu Leu Leu Gln Ala Gln Gln Pro Ser Leu Gln Leu Ser Gln Thr 
            580                 585                 590         


Lys Ser Pro Gln His Leu Gln Gln Thr Ile Val Gly Gln Ile Asn Tyr 
        595                 600                 605             


Ile Val Arg Gln Pro Ala Pro Val Gln Ser Gln Ser Gln Glu Glu Thr 
    610                 615                 620                 


Leu Gln Ala Thr Asp Glu Pro Pro Ala Ser Gln Gly Ser Lys Pro Ala 
625                 630                 635                 640 


Leu Pro Leu Asp Lys Asn Thr Ala Ala Ala Leu Pro Gln Ala Ser Gly 
                645                 650                 655     


Glu Glu Thr Pro Leu Ser Val Pro Pro Val Asp Ser Thr Ile Gln His 
            660                 665                 670         


Ser Ser Pro Asn Val Val Arg Lys His Ser Thr Ser Val Ser Ile Met 
        675                 680                 685             


Gly Phe Ser Asn Thr Leu Glu Met Glu Leu Ser Ser Thr Arg Leu Glu 
    690                 695                 700                 


Arg Pro Leu Glu Pro Gln Ile Gln Ser Val Ser His Leu Thr Ala Gly 
705                 710                 715                 720 


Ala Pro Gln Ala Val Pro Ser Leu Leu Ser Ala Pro Pro Lys Met Val 
                725                 730                 735     


Ser Ser Leu Thr Ser Val Gln Asn Gln Ala Met Pro Ser Leu Thr Thr 
            740                 745                 750         


Ser His Leu Gln Thr Val Pro Ser Leu Val His Ser Thr Phe Gln Ser 
        755                 760                 765             


Met Pro Asn Leu Ile Ser Asp Ser Pro Gln Ala Met Ala Ser Leu Ala 
    770                 775                 780                 


Ser Asp His Pro Gln Ala Gly Pro Ser Leu Met Ser Gly His Thr Gln 
785                 790                 795                 800 


Ala Val Pro Ser Leu Ala Thr Cys Pro Leu Gln Ser Ile Pro Pro Val 
                805                 810                 815     


Ser Asp Met Gln Pro Glu Thr Gly Ser Ser Ser Ser Ser Gly Arg Thr 
            820                 825                 830         


Ser Gly Ser Leu Cys Pro Arg Asp Gly Ala Asp Pro Ser Leu Glu Asn 
        835                 840                 845             


Ala Leu Cys Lys Val Lys Leu Glu Glu Pro Ile Asn Leu Ser Val Lys 
    850                 855                 860                 


Lys Pro Pro Leu Ala Pro Val Val Ser Thr Ser Thr Ala Leu Gln Gln 
865                 870                 875                 880 


Tyr Gln Asn Pro Lys Glu Cys Glu Asn Phe Glu Gln Gly Ala Leu Glu 
                885                 890                 895     


Leu Asp Ala Lys Glu Asn Gln Ser Ile Arg Ala Phe Asn Ser Glu His 
            900                 905                 910         


Lys Ile Pro Tyr Val Arg Leu Glu Arg Leu Lys Ile Cys Ala Ala Ser 
        915                 920                 925             


Ser Gly Glu Met Pro Val Phe Lys Leu Lys Pro Gln Lys Asn Asp Gln 
    930                 935                 940                 


Asp Gly Ser Phe Leu Leu Ile Ile Glu Cys Gly Thr Glu Ser Ser Ser 
945                 950                 955                 960 


Met Ser Ile Lys Val Ser Gln Asp Arg Leu Ser Glu Ala Thr Gln Ala 
                965                 970                 975     


Pro Gly Leu Glu Gly Arg Lys Val Thr Val Thr Ser Leu Ala Gly Gln 
            980                 985                 990         


Arg Pro Pro Glu Val Glu Gly Thr  Ser Pro Glu Glu His  Arg Leu Ile 
        995                 1000                 1005             


Pro Arg  Thr Pro Gly Ala Lys  Lys Gly Pro Pro Ala  Pro Ile Glu 
    1010                 1015                 1020             


Asn Glu  Asp Phe Cys Ala Val  Cys Leu Asn Gly Gly  Glu Leu Leu 
    1025                 1030                 1035             


Cys Cys  Asp Arg Cys Pro Lys  Val Phe His Leu Ser  Cys His Val 
    1040                 1045                 1050             


Pro Ala  Leu Leu Ser Phe Pro  Gly Gly Glu Trp Val  Cys Thr Leu 
    1055                 1060                 1065             


Cys Arg  Ser Leu Thr Gln Pro  Glu Met Glu Tyr Asp  Cys Glu Asn 
    1070                 1075                 1080             


Ala Cys  Tyr Asn Gln Pro Gly  Met Arg Ala Ser Pro  Gly Leu Ser 
    1085                 1090                 1095             


Met Tyr  Asp Gln Lys Lys Cys  Glu Lys Leu Val Leu  Ser Leu Cys 
    1100                 1105                 1110             


Cys Asn  Asn Leu Ser Leu Pro  Phe His Glu Pro Val  Ser Pro Leu 
    1115                 1120                 1125             


Ala Arg  His Tyr Tyr Gln Ile  Ile Lys Arg Pro Met  Asp Leu Ser 
    1130                 1135                 1140             


Ile Ile  Arg Arg Lys Leu Gln  Lys Lys Asp Pro Ala  His Tyr Thr 
    1145                 1150                 1155             


Thr Pro  Glu Glu Val Val Ser  Asp Val Arg Leu Met  Phe Trp Asn 
    1160                 1165                 1170             


Cys Ala  Lys Phe Asn Tyr Pro  Asp Ser Glu Val Ala  Glu Ala Gly 
    1175                 1180                 1185             


Arg Cys  Leu Glu Val Phe Phe  Glu Gly Trp Leu Lys  Glu Ile Tyr 
    1190                 1195                 1200             


Pro Glu  Lys Arg Phe Ala Gln  Pro Arg Gln Glu Asp  Ser Asp Ser 
    1205                 1210                 1215             


Glu Glu  Val Ser Ser Glu Ser  Gly Cys Ser Thr Pro  Gln Gly Phe 
    1220                 1225                 1230             


Pro Trp  Pro Pro Tyr Met Gln  Glu Gly Ile Gln Pro  Lys Arg Arg 
    1235                 1240                 1245             


Arg Arg  His Met Glu Asn Glu  Arg Ala Lys Arg Met  Ser Phe Arg 
    1250                 1255                 1260             


Leu Ala  Asn Ser Ile Ser Gln  Val 
    1265                 1270     


<210>  513
<211>  1700
<212>  DNA
<213>  Homo sapiens

<400>  513
cacaaattcc ctctgtctcc tccagaatcc agaaaagaat aattacaata ttttcaaaat       60

ggaaagttcc catgccaaag agtttgcctt cttcaccaaa ctatgatttc gtgatgttct      120

taaaggtagt gtacaccagg tttttacatt cttattttga atgtagtttt agtgtttgtg      180

tgatttgttt ttcagcctgg cctgcagact agcaacccaa gacttatact gcccaatttg      240

acagctcatt tttattttag tttcaccata tacatgaatt ggacttacaa ttccagaaaa      300

attaaaggct caagaatggg gcatgagtac acactgtgtg ctaaggaaag aatatttgga      360

ttgaattgaa cccctgcaga acgtggacta tttagagacc tgaatttggc cttgggtgaa      420

tacctgcctt gggttggcca actagcagtc aacagcaatg agccaaaaga gacaaaccaa      480

gtttcaaaat ggcaaatcaa agacttcaga aaatagctca gctaaacgtg agaaaggaat      540

ggttgtcaat agcaaagaga tttctgatgc agtcgggcaa tcaaaatttg ttctagagaa      600

ccttcggcat tacacagtcc atccaaattt ggcccagtac tataagcctt tgaaggccac      660

tgccctgcag aaattcctgg ctcaaaacag gaaaaacacc agcttcatgt taaaagtaac      720

acagtatgac caggataaga cgttactgat tatgaccaac aacccacctc cctgctcaat      780

cacccagcaa gacaaggaga gtgcatcaaa atatttttcc aaggagttac tgctcaaggt      840

catggaaagt catcatcagc acaaacccac tgagaacctc tggctgcccc gcatgcctca      900

gaaaaaaaag ttaagatcta agctgaaacc aatcttccct ttgatactgt cggatgatcc      960

cacatccaag cgagaacaat ggtttaggtt ttccactgac aatgatttca agagcgaagg     1020

gaagtattca aaagtctacg ctttgaggac acagaagaaa atgtaccctc agctcacctt     1080

tgctccagtc catgagagag atatgaggaa agatgcttcc aagaagtcag cgagtgaaag     1140

gccaatttcc aaagtgattc gggaaccact gacactcgca tcgctcttgg aagacatgcc     1200

caccagaacc gcgcccgggg agagcgcctt ccgcaacggg agggccccgc agtggattat     1260

caaaaaggcc acggtcatcg ggtgaacaca gacccctcag tcctcccgcc tcgctctctt     1320

gagactgagg ggtccgcaga agtcgccacc caaataaaac cacattcctg ctgctgcggg     1380

cgtgggctcc cgggtcgcaa gccgggaggg tcgagccgaa gtctccggcg ggccgcaaga     1440

ggagaagggg gcgtggctgc gtcccggggg ccgagggcgg ccggggaggg cgggccttgg     1500

ccccgagtga aggcgcggcg gcccaaccgg cgtgagagcg cggggccggc cttcctgcag     1560

cctcttccgc tcgccggctg cggcgcctgg gacggttgcg gtgggtctgg gcgctgggaa     1620

gtcgtccaag atgattaaaa aattcgacaa gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa                                                 1700


<210>  514
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Ser Gln Lys Arg Gln Thr Lys Phe Gln Asn Gly Lys Ser Lys Thr 
1               5                   10                  15      


Ser Glu Asn Ser Ser Ala Lys Arg Glu Lys Gly Met Val Val Asn Ser 
            20                  25                  30          


Lys Glu Ile Ser Asp Ala Val Gly Gln Ser Lys Phe Val Leu Glu Asn 
        35                  40                  45              


Leu Arg His Tyr Thr Val His Pro Asn Leu Ala Gln Tyr Tyr Lys Pro 
    50                  55                  60                  


Leu Lys Ala Thr Ala Leu Gln Lys Phe Leu Ala Gln Asn Arg Lys Asn 
65                  70                  75                  80  


Thr Ser Phe Met Leu Lys Val Thr Gln Tyr Asp Gln Asp Lys Thr Leu 
                85                  90                  95      


Leu Ile Met Thr Asn Asn Pro Pro Pro Cys Ser Ile Thr Gln Gln Asp 
            100                 105                 110         


Lys Glu Ser Ala Ser Lys Tyr Phe Ser Lys Glu Leu Leu Leu Lys Val 
        115                 120                 125             


Met Glu Ser His His Gln His Lys Pro Thr Glu Asn Leu Trp Leu Pro 
    130                 135                 140                 


Arg Met Pro Gln Lys Lys Lys Leu Arg Ser Lys Leu Lys Pro Ile Phe 
145                 150                 155                 160 


Pro Leu Ile Leu Ser Asp Asp Pro Thr Ser Lys Arg Glu Gln Trp Phe 
                165                 170                 175     


Arg Phe Ser Thr Asp Asn Asp Phe Lys Ser Glu Gly Lys Tyr Ser Lys 
            180                 185                 190         


Val Tyr Ala Leu Arg Thr Gln Lys Lys Met Tyr Pro Gln Leu Thr Phe 
        195                 200                 205             


Ala Pro Val His Glu Arg Asp Met Arg Lys Asp Ala Ser Lys Lys Ser 
    210                 215                 220                 


Ala Ser Glu Arg Pro Ile Ser Lys Val Ile Arg Glu Pro Leu Thr Leu 
225                 230                 235                 240 


Ala Ser Leu Leu Glu Asp Met Pro Thr Arg Thr Ala Pro Gly Glu Ser 
                245                 250                 255     


Ala Phe Arg Asn Gly Arg Ala Pro Gln Trp Ile Ile Lys Lys Ala Thr 
            260                 265                 270         


Val Ile Gly 
        275 


<210>  515
<211>  2472
<212>  DNA
<213>  Homo sapiens

<400>  515
agctggagcg ttcggtggac agtgagcatg cgtaccatat ctgaagttcg taaattgaaa       60

ttgaacatgc gtaattaatc tttctgaata ggaaaaaata tatacacaac aaaactctcc      120

gtttatggaa catgcgcatt tgttctcagt aagtttttcg ttttgaaagt gagcatgcgc      180

atggtgagta ggttggtccg aagtttgaac cggacagaag cgctggtcgg cgtctggcgg      240

ttgtttttag aggtaataca cctagtttgt ggctcagcat gtcaattgta acagtgcaac      300

ttggtcagtg tggcaatcag attggttttg aagtttttga tgctttgctt agtgactcac      360

acagttccca gggactctgc tctatgagag agaatgaggc atatcaagca tcttgcaaag      420

aaagattctt cagtgaggag gagaatggag ttccaattgc ccgggctgtt cttgttgaca      480

tggaacccaa agttatcaat caaatgctgt caaaggctgc ccagtctggc caatggaaat      540

atggtcaaca tgcatgcttc tgtcaaaaac aaggttctgg aaacaactgg gcatatggtt      600

actctgttca tggacccagg catgaagaat ctataatgaa cataatccgg aaggaagtgg      660

agaaatgtga ctctttcagt ggttttttca tcataatgag tatggctggg ggcacaggat      720

caggattagg agctttcgtt acacagaatt tagaagatca gtactcaaac tcattgaaaa      780

tgaatcagat tatttggcct tatggaactg gtgaggttat tgttcaaaac tacaactcca      840

ttttgacact ttctcacttg taccgatctt cagacgccct ccttcttcat gagaatgatg      900

ccatccataa gatctgtgca aaactgatga atatcaagca gatctccttt agtgatatca      960

atcaagtcct cgcacatcag ctgggaagtg tgttccagcc tacttattct gcagaaagct     1020

catttcacta cagacgaaat ccactaggag acttaatgga gcatttagtt ccccatcctg     1080

aattcaagat gctgagtgtt cgtaacattc ctcacatgtc tgagaattca ttggcataca     1140

ccacatttac ttgggctggc ctcctcaagc atttgagaca gatgctcatt tctaatgcaa     1200

agatggaaga aggtattgat aggcatgtat ggcctccttt atcaggactt cctcctctta     1260

gtaaaatgtc tctcaacaag gacctgcatt ttaacacttc cattgctaac ttggtcattc     1320

ttcgtgggaa agatgtgcaa agtgcagatg tggagggatt taaagatcca gctctgtata     1380

cttcctggtt gaagcctgtt aatgctttca acgtgtggaa aacccagcgg gcctttagca     1440

aatatgagaa gtctgcagtg ttggtcagca acagccagtt cttagtaaaa ccacttgata     1500

tgattgttgg gaaggcatgg aatatgtttg cttcaaaagc ctacattcat cagtacacaa     1560

aatttggaat cgaagaagag gactttttag acagtttcac gtcattagag caggttgttg     1620

ccagttactg taatctctga tcttgaacaa tgggaaaagt ataccttaag gcatttctgg     1680

actaaaatat tttcaatact attttctctg taaagttttc aaagttctcc atcctggcta     1740

acacggtgaa acaccgtctc taccagaaaa tacaaaaaat tagccaggcg cggtggcggg     1800

tgcctgtagt cccagctact cgggaggctg aggcaggaga atgacgtgaa cccaggaggc     1860

ggagcttgca gtgagccgag atcgcgccac tgcactccag cctgggcgac agagcgagac     1920

tccgtctcaa aaaaaaaaaa aaaaaaaaat gttttcaaag ttccattctg ttaaagtaac     1980

cacgtagaat gctgagtcta ttctgcatac tatgcccaca gaaaaggaag aaaacttttt     2040

aaaatggaga atcgcatgtt ttcaatgaaa acattcactt ggtatttcat ttgtaagaaa     2100

aaaaaatggt gcttttataa agaactttgg ggaaacactt tgctgaaatg ttgggactct     2160

ggaactagcc aagaaaagag aatattctct ttgtctacat gttcctaaat ctttactcca     2220

aaacaactcc aaaaacaact cacaaagcat gaaccaaact ttcacagcat aatttcaagc     2280

taaggaattg taattctgta cttaatatat tcatgtttga aatgaatgct ttgaaccaca     2340

ggagggagat gttgtcaaat gctacagtgt gaacatgtat tttgaatatt ctgtaacagg     2400

gcaagtttcc actctaagca gctatttaaa aataaatatg aggattttgg taataaatgc     2460

ttatgcttaa gt                                                         2472


<210>  516
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly 
1               5                   10                  15      


Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly 
            20                  25                  30          


Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu 
        35                  40                  45              


Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Met Leu Ser Lys Ala 
65                  70                  75                  80  


Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln 
                85                  90                  95      


Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val His Gly 
            100                 105                 110         


Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu Val Glu 
        115                 120                 125             


Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met Ala Gly 
    130                 135                 140                 


Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu Glu Asp 
145                 150                 155                 160 


Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro Tyr Gly 
                165                 170                 175     


Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr Leu Ser 
            180                 185                 190         


His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn Asp Ala 
        195                 200                 205             


Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile Ser Phe 
    210                 215                 220                 


Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val Phe Gln 
225                 230                 235                 240 


Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn Pro Leu 
                245                 250                 255     


Gly Asp Leu Met Glu His Leu Val Pro His Pro Glu Phe Lys Met Leu 
            260                 265                 270         


Ser Val Arg Asn Ile Pro His Met Ser Glu Asn Ser Leu Ala Tyr Thr 
        275                 280                 285             


Thr Phe Thr Trp Ala Gly Leu Leu Lys His Leu Arg Gln Met Leu Ile 
    290                 295                 300                 


Ser Asn Ala Lys Met Glu Glu Gly Ile Asp Arg His Val Trp Pro Pro 
305                 310                 315                 320 


Leu Ser Gly Leu Pro Pro Leu Ser Lys Met Ser Leu Asn Lys Asp Leu 
                325                 330                 335     


His Phe Asn Thr Ser Ile Ala Asn Leu Val Ile Leu Arg Gly Lys Asp 
            340                 345                 350         


Val Gln Ser Ala Asp Val Glu Gly Phe Lys Asp Pro Ala Leu Tyr Thr 
        355                 360                 365             


Ser Trp Leu Lys Pro Val Asn Ala Phe Asn Val Trp Lys Thr Gln Arg 
    370                 375                 380                 


Ala Phe Ser Lys Tyr Glu Lys Ser Ala Val Leu Val Ser Asn Ser Gln 
385                 390                 395                 400 


Phe Leu Val Lys Pro Leu Asp Met Ile Val Gly Lys Ala Trp Asn Met 
                405                 410                 415     


Phe Ala Ser Lys Ala Tyr Ile His Gln Tyr Thr Lys Phe Gly Ile Glu 
            420                 425                 430         


Glu Glu Asp Phe Leu Asp Ser Phe Thr Ser Leu Glu Gln Val Val Ala 
        435                 440                 445             


Ser Tyr Cys Asn Leu 
    450             


<210>  517
<211>  3448
<212>  DNA
<213>  Homo sapiens

<400>  517
tcggccaccg ctcgcttcaa tatggctgcc cccagggaga gacgaggcta ccatgaagga       60

gccgagcgca gaccctgagt ccgtcaccca tggatcgcag cgcggagttc aggaaatgga      120

aggcgcaatg tttgagcaaa gcggacctca gccggaaggg cagtgttgac gaggatgtgg      180

tagagcttgt gcagtttctg aacatgcgag atcagttttt caccaccagc tcctgcgctg      240

gccgcatcct actccttgac cggggtataa atggttttga ggttcagaaa caaaactgtt      300

gctggctact ggttacacac aaactttgtg taaaagatga tgtgattgta gctctgaaga      360

aagcaaatgg tgatgccact ttgaaatttg aaccatttgt tcttcatgtg cagtgtcgac      420

aattgcagga tgcacagatt ctgcattcca tggcaataga ttctggtttc aggaactctg      480

gcataacggt gggaaagaga ggaaaaacta tgttggctgt ccggagtaca catggcttag      540

aagttccatt aagccataag ggaaaactga tggtgacaga ggaatatatt gacttcctgt      600

taaatgtggc aaatcaaaaa atggaggaaa acaagaaaag aattgagagg ttttacaact      660

gcctacagca tgctttggaa agggaaacga tgactaactt acatcccaag atcaaagaga      720

aaaataactc atcatatatt cataagaaaa aaagaaaccc agaaaaaaca cgtgcccagt      780

gtattactaa agaaagtgat gaagaacttg aaaatgatga tgatgatgat ctaggaatca      840

atgttaccat cttccctgaa gattactaag ctttggttct gatgtgtctt ggccgtaatg      900

tttctagtag gttttataaa gctgctcttc ataagagtat tttagtttgt tgagtgtatc      960

agccattcat aagccagtaa tgacaagtgc agagcttcaa actataactt tgttgcccag     1020

aggatgtgca gttgtcatct aagctctcag cagtacccgg cttatcctac gacttcacct     1080

gaaatgctat agttatccct acttttttac cagtttctcc cagaagcacc tgcttaataa     1140

atcaaagatg tttgaatggt gtcttattct gaaataacct gacctaagac aggtatttag     1200

attattttgg atacattttg aaaagggata gcataaatat tttaagtaaa aagaccttta     1260

ttttaaataa tagtggatat tttaatgctg gaaattagca ttatagttga tatgccagaa     1320

attatatctt tggttgtgat ttaaacttat gctataaact aaattaatga tgtaaataca     1380

tagttttaaa cattctttta gggacatgta acttttaagt atcacttcaa taatacgtat     1440

tattatagga acaaagattt gggaataatt gattacaggt gaggaagtac tggaattcca     1500

gttcaaggag ataccatttc atttaggact aaaaggacaa gatacaagtt cacatgatgg     1560

gaaaaatcag aaaacctctc gcagacaaag ggtatataat ggatatgagg catcaaaaag     1620

catggtatag tcagtgatgg ggaatagtcc agaaaggctg aaacacagca tgtgatgcga     1680

gtcaaggtag ttgatgccca actgtgaagg gccgttctaa tctagcatgg aggtagacag     1740

tgtttcctta atatggctgc atatcagaat tacctaggtc aggacgaggc atggagatgc     1800

tactttaata ggccctgccg cagatcttcc aaaccagaat cttaatcctg gagtctagga     1860

atctttattt ttcacacaac tcatccaagt ggttctgata aaatcagtcc agcactttta     1920

gaacccactg ataacagact tattcctgga gacagcattt gaggaggaat tgaagatttt     1980

tctaatgaaa agaaaaaggg tcacatgaac agatgttgca gtgtacctgt gccagggatt     2040

tcatgtgtac actttatagg agaataagca agagcttagg taagttatag tccttaccat     2100

tgggtctaag gcagtttcca ggaaagcatg gcaactcgtt cagctatgta agttgaactc     2160

tgtaccactt gggagggaac attcccctag atgacaatgt cagtggcact cgaagttgtg     2220

cagtgcacat tcttatctac caacatatac agcagtcctt ctgggaagga aatttgggca     2280

ggaaagggaa ctcacagtgt cggaatgcct ggagcatttc ttctagtctg gtggacagaa     2340

tatgaaagta tctgcctggc agtgcagtaa atgaaaagag aagataaatg aataaaaaaa     2400

aaagttataa ataacagtag gaaagagaga gtgcaggtgg aacgagccta tcctgtggtg     2460

aaatgacaac acattctgca gttttaaaat ctaagaggct cattgacttt tcttcattca     2520

tttaaattga tctccaagaa aactatgtat tttaaagatt ccataaactg aatatatgaa     2580

tgagaattaa gaagagaggg gctgcttcct aatctgttta tataaggtat agtatagtat     2640

aatctgttta tataaggtta gtagagagga gacaccaggt gctggccata aacctaagaa     2700

gacattgaat cccattcact ccttaacatt ccttaatata cattcatgag ctacataaca     2760

ttttaatcat caatgatgga ccatatacca tatacgatat ggtggcccca taagattata     2820

atggacctga aaaattccta ttgctagtga tgtggtcatt gtaaagctgt agcacaacac     2880

attacccacg tttgtggtga cagtcatata aaagtatggt acatataatt atgtacagtg     2940

catacataat acttgataat atgttactgg tttgtgtctt tgctatgctt tttatcatta     3000

ttttagggta tactacttaa aatgttaact gtaaaacagc ttctgacagg tccttcagga     3060

agtactccag aagaaggcat tgttatcata gaaggtgaca gcttcatgtg tgttattgcc     3120

cctgaagacc ttccagtggt acaagatgtg gaggaggaag acagtgatac tgaggattct     3180

gaccctgtgt aggcttaggc taatgtgtgt gtttatatct tagtttttca caaaaaggtt     3240

tttccaatgt taaaaaaaat atataaaaaa gcttatagaa taaggatata aagaaatatt     3300

ttgtacagct gtacaataag ctaagcatta ttaccaaaga gtcaaaaagt tttaagaaat     3360

taaagtttat aaaccaaatg ttcattgtga gccaaggtta atttattgaa gaaataaaac     3420

atttttaatg aaaaaaaaaa aaaaaaaa                                        3448


<210>  518
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Asp Arg Ser Ala Glu Phe Arg Lys Trp Lys Ala Gln Cys Leu Ser 
1               5                   10                  15      


Lys Ala Asp Leu Ser Arg Lys Gly Ser Val Asp Glu Asp Val Val Glu 
            20                  25                  30          


Leu Val Gln Phe Leu Asn Met Arg Asp Gln Phe Phe Thr Thr Ser Ser 
        35                  40                  45              


Cys Ala Gly Arg Ile Leu Leu Leu Asp Arg Gly Ile Asn Gly Phe Glu 
    50                  55                  60                  


Val Gln Lys Gln Asn Cys Cys Trp Leu Leu Val Thr His Lys Leu Cys 
65                  70                  75                  80  


Val Lys Asp Asp Val Ile Val Ala Leu Lys Lys Ala Asn Gly Asp Ala 
                85                  90                  95      


Thr Leu Lys Phe Glu Pro Phe Val Leu His Val Gln Cys Arg Gln Leu 
            100                 105                 110         


Gln Asp Ala Gln Ile Leu His Ser Met Ala Ile Asp Ser Gly Phe Arg 
        115                 120                 125             


Asn Ser Gly Ile Thr Val Gly Lys Arg Gly Lys Thr Met Leu Ala Val 
    130                 135                 140                 


Arg Ser Thr His Gly Leu Glu Val Pro Leu Ser His Lys Gly Lys Leu 
145                 150                 155                 160 


Met Val Thr Glu Glu Tyr Ile Asp Phe Leu Leu Asn Val Ala Asn Gln 
                165                 170                 175     


Lys Met Glu Glu Asn Lys Lys Arg Ile Glu Arg Phe Tyr Asn Cys Leu 
            180                 185                 190         


Gln His Ala Leu Glu Arg Glu Thr Met Thr Asn Leu His Pro Lys Ile 
        195                 200                 205             


Lys Glu Lys Asn Asn Ser Ser Tyr Ile His Lys Lys Lys Arg Asn Pro 
    210                 215                 220                 


Glu Lys Thr Arg Ala Gln Cys Ile Thr Lys Glu Ser Asp Glu Glu Leu 
225                 230                 235                 240 


Glu Asn Asp Asp Asp Asp Asp Leu Gly Ile Asn Val Thr Ile Phe Pro 
                245                 250                 255     


Glu Asp Tyr 
            


<210>  519
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  519
ttgctgtgat gactatctta ggacaccttt ggaataacta tgaaagaaaa ctattctgag       60

caacc                                                                   65


<210>  520
<211>  2823
<212>  DNA
<213>  Homo sapiens

<400>  520
gctccgtgcg caagcgcttt cggcggcgat taggtggttt ccggttccgc tatcttcttt       60

ttcttcagcg aggcggccga gctggttggt ggcggcggtc gtgcggacgc aaacatgcag      120

atctttgtga agaccctcac tggcaaaacc atcacccttg aggtcgagcc cagtgacacc      180

attgagaatg tcaaagccaa aattcaagac aaggagggta tcccacctga ccagcagcgt      240

ctgatatttg ccggcaaaca gctggaggat ggccgcactc tctcagacta caacatccag      300

aaagagtcca ccctgcacct ggtgttgcgc ctgcgaggtg gcattattga gccttctctc      360

cgccagcttg cccagaaata caactgcgac aagatgatct gccgcaagtg ctatgctcgc      420

cttcaccctc gtgctgtcaa ctgccgcaag aagaagtgtg gtcacaccaa caacctgcgt      480

cccaagaaga aggtcaaata aggtggttct ttccttgaag ggcagcctcc tgcccaggcc      540

ccgtggccct ggagcctcaa taaagtgtcc ctttcattga ctggagcagc aattggtgtc      600

ctcatggctg atctgtccag ggaggtggct gaagagtggg catctccctt agggactcta      660

ctcagcactc cattctgtgc cacctgtggg gtcttctgtc ctagattctg tcacatcggc      720

attggtccct gccctatgcc cctgactctg gatttgtcat ctgtaaaact ggagtaaaaa      780

cctcagtcgt gtaattggtg ggactgagga tcagttttgt cattgctggg atcctgtcag      840

gcactttgag gtgtccctca ggccttggcc ctgaagtgtc taggtgtgtg gagatgggta      900

gaaaattagg tacacccaat ggtgtagaac gttgattctc aaattttttt attttataca      960

aatggggtct cactatgttg tccaggctgg tcttgaactc ctgggctcaa gccatccgcc     1020

catctcagcc cctcaaagtg ttgggattac aagcaagaac tgccatgcct gacccagttc     1080

tcagtttttt gtttgtttgt ttgtttgttt gttttgagac ggagtcttgc tctgtcgccc     1140

aggctggagt gcagtggcgc agtctcggct tactacaacc tctgcctccg gggttcacat     1200

ccttctcctg cctcagcctc ccgagtagct gggactacag gtgcccgcca caactcctgg     1260

ctaatttttt gtatttttag tagagacggg gtttcactgg gttagccagg ttggtctcga     1320

tctcctgacc ttgtgatcca ttcgccttgg cctcccagaa tgctggtatt acaggcgtga     1380

gccagcacgc ctggcccagt tactcagttt tgaatctgag gccgtgacat cactcatggt     1440

ctgcagtcag tgctctgccc ctgagctgta ccctctccta tgataatcac tcttaagaag     1500

ggcaaccctt ggtgttttcc ccttaaggtc acccaggctg gaatgcagtg gtgtggtcat     1560

ggctccctgt accctggaac tcaggcttgg gtgatcctct ctcctttgcc tccgaagtag     1620

ccaggactac aggtgtgcac ccaccaccac actcagataa ttgctttggt gtttttaaag     1680

cttgtaatga tcagtaggct gaggtgggca aatcataagg tcaagagttt tttagatggg     1740

gtgagcacag accaattcct gttttattta ctgatttaaa attttgagac agtctcactg     1800

tcacccaggt tggggtgcag tggtaggatc atagcttgct gcagccttga tctcccagga     1860

tcttgcctca gcctcccgag tagctgggac tgcatgcttg tgccaccaca ctcggttaat     1920

attttgtaga gatggggtct tgctatgttg cccaggctgg cttcaaactc ctgaacttaa     1980

aagcctcctg tttagttttg gttttttatc actttttttt tttttttttg agatggagcc     2040

ttgctcccat cgtgcaggct ggagtgcggt ggcgcagtct cggctcactg cagcttctgc     2100

ctctcgggtt caagcgattc tcctttctca gcctcttgag tagctggaat taccagtgtg     2160

cgccaccacc accacgcctg gctagttttt ctgtttttag tagagacagg gttttgctat     2220

gttggccagg ctggtcttga actactgacc tcttgtgatc tacctgtctt ggccttccaa     2280

agtgctagga ttacaagcgt aagccacagc gcctggcctt gctacatttt tttttttttt     2340

ttttttttta cagacatggt ctcgctatgt tgcccagaat ggttttgcac tgggtccaag     2400

cagttctgcc gcagcctccc aaagtgctgg gattacaggg gtgaggcacc ttgctggccc     2460

ctgttttgat tagggtgcag tgctggtgaa gccggtgcac gaggccagtg atgcatccta     2520

atgaggggtg gagttggcgg gacttcctgg gccagtttgg ggactttcac aaaagacccc     2580

catgactcag ggttttgagt tcttaactga tcgaatgaag gattcaaaat taaccactcc     2640

aaggggggat tgaaggaaga accactctta atggacaaaa agaaagaaag gggagggagt     2700

aacagggata tgagctctag ccgcccaagc tagcaatggc aacccttctg ggtccccttc     2760

cagcatgtgg aagctttcct ttcgcttcat tcaataaaca gctgctgctc aaaaaaaaaa     2820

aaa                                                                   2823


<210>  521
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  521

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro 
65                  70                  75                  80  


Ser Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys 
                85                  90                  95      


Arg Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys 
            100                 105                 110         


Lys Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys 
        115                 120                 125             


<210>  522
<211>  2801
<212>  DNA
<213>  Homo sapiens

<400>  522
gctccgtgcg caagcgcttt cggcggcgat taggtggttt ccggttccgc tatcttcttt       60

ttcttcagcg aggcggccga gctgacgcaa acatgcagat ctttgtgaag accctcactg      120

gcaaaaccat cacccttgag gtcgagccca gtgacaccat tgagaatgtc aaagccaaaa      180

ttcaagacaa ggagggtatc ccacctgacc agcagcgtct gatatttgcc ggcaaacagc      240

tggaggatgg ccgcactctc tcagactaca acatccagaa agagtccacc ctgcacctgg      300

tgttgcgcct gcgaggtggc attattgagc cttctctccg ccagcttgcc cagaaataca      360

actgcgacaa gatgatctgc cgcaagtgct atgctcgcct tcaccctcgt gctgtcaact      420

gccgcaagaa gaagtgtggt cacaccaaca acctgcgtcc caagaagaag gtcaaataag      480

gtggttcttt ccttgaaggg cagcctcctg cccaggcccc gtggccctgg agcctcaata      540

aagtgtccct ttcattgact ggagcagcaa ttggtgtcct catggctgat ctgtccaggg      600

aggtggctga agagtgggca tctcccttag ggactctact cagcactcca ttctgtgcca      660

cctgtggggt cttctgtcct agattctgtc acatcggcat tggtccctgc cctatgcccc      720

tgactctgga tttgtcatct gtaaaactgg agtaaaaacc tcagtcgtgt aattggtggg      780

actgaggatc agttttgtca ttgctgggat cctgtcaggc actttgaggt gtccctcagg      840

ccttggccct gaagtgtcta ggtgtgtgga gatgggtaga aaattaggta cacccaatgg      900

tgtagaacgt tgattctcaa atttttttat tttatacaaa tggggtctca ctatgttgtc      960

caggctggtc ttgaactcct gggctcaagc catccgccca tctcagcccc tcaaagtgtt     1020

gggattacaa gcaagaactg ccatgcctga cccagttctc agttttttgt ttgtttgttt     1080

gtttgtttgt tttgagacgg agtcttgctc tgtcgcccag gctggagtgc agtggcgcag     1140

tctcggctta ctacaacctc tgcctccggg gttcacatcc ttctcctgcc tcagcctccc     1200

gagtagctgg gactacaggt gcccgccaca actcctggct aattttttgt atttttagta     1260

gagacggggt ttcactgggt tagccaggtt ggtctcgatc tcctgacctt gtgatccatt     1320

cgccttggcc tcccagaatg ctggtattac aggcgtgagc cagcacgcct ggcccagtta     1380

ctcagttttg aatctgaggc cgtgacatca ctcatggtct gcagtcagtg ctctgcccct     1440

gagctgtacc ctctcctatg ataatcactc ttaagaaggg caacccttgg tgttttcccc     1500

ttaaggtcac ccaggctgga atgcagtggt gtggtcatgg ctccctgtac cctggaactc     1560

aggcttgggt gatcctctct cctttgcctc cgaagtagcc aggactacag gtgtgcaccc     1620

accaccacac tcagataatt gctttggtgt ttttaaagct tgtaatgatc agtaggctga     1680

ggtgggcaaa tcataaggtc aagagttttt tagatggggt gagcacagac caattcctgt     1740

tttatttact gatttaaaat tttgagacag tctcactgtc acccaggttg gggtgcagtg     1800

gtaggatcat agcttgctgc agccttgatc tcccaggatc ttgcctcagc ctcccgagta     1860

gctgggactg catgcttgtg ccaccacact cggttaatat tttgtagaga tggggtcttg     1920

ctatgttgcc caggctggct tcaaactcct gaacttaaaa gcctcctgtt tagttttggt     1980

tttttatcac tttttttttt tttttttgag atggagcctt gctcccatcg tgcaggctgg     2040

agtgcggtgg cgcagtctcg gctcactgca gcttctgcct ctcgggttca agcgattctc     2100

ctttctcagc ctcttgagta gctggaatta ccagtgtgcg ccaccaccac cacgcctggc     2160

tagtttttct gtttttagta gagacagggt tttgctatgt tggccaggct ggtcttgaac     2220

tactgacctc ttgtgatcta cctgtcttgg ccttccaaag tgctaggatt acaagcgtaa     2280

gccacagcgc ctggccttgc tacatttttt tttttttttt tttttttaca gacatggtct     2340

cgctatgttg cccagaatgg ttttgcactg ggtccaagca gttctgccgc agcctcccaa     2400

agtgctggga ttacaggggt gaggcacctt gctggcccct gttttgatta gggtgcagtg     2460

ctggtgaagc cggtgcacga ggccagtgat gcatcctaat gaggggtgga gttggcggga     2520

cttcctgggc cagtttgggg actttcacaa aagaccccca tgactcaggg ttttgagttc     2580

ttaactgatc gaatgaagga ttcaaaatta accactccaa ggggggattg aaggaagaac     2640

cactcttaat ggacaaaaag aaagaaaggg gagggagtaa cagggatatg agctctagcc     2700

gcccaagcta gcaatggcaa cccttctggg tccccttcca gcatgtggaa gctttccttt     2760

cgcttcattc aataaacagc tgctgctcaa aaaaaaaaaa a                         2801


<210>  523
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro 
65                  70                  75                  80  


Ser Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys 
                85                  90                  95      


Arg Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys 
            100                 105                 110         


Lys Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys 
        115                 120                 125             


<210>  524
<211>  3399
<212>  DNA
<213>  Homo sapiens

<400>  524
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta       60

tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg      120

agtcccaatg aaacgggcag ccatggccct ccacagcccg cagtatattt ttggagattt      180

tagccctgat gaattcaatc aattctttgt gactcctcga tcttcagttg agcttcctcc      240

atacagtgga acagttctgt gtggcacaca ggctgtggat aaactacctg atggacaaga      300

atatcagaga attgagtttg gtgtcgatga agtcattgaa cccagtgaca ctttgccgag      360

aacccccagc tacagtattt caagcacact gaaccctcag gcccctgaat ttattctcgg      420

ttgtacagct tccaaaataa cccctgatgg tatcactaaa gaagcaagct atggctccat      480

cgactgccag tacccaggct ctgccctcgc tttggatgga agttctaatg tggaggcgga      540

agttttggaa aatgatggtg tctcaggtgg tcttggacaa agggagcgta aaaagaagaa      600

aaagcggcca cctggatatt acagctattt gaaagatggt ggcgatgata gtatctccac      660

agaagccctg gtcaatggcc atgccaattc agcagtcccg aacagtgtca gtgcagagga      720

tgcagaattt atgggtgaca tgcccccgtc agttacgccc aggacttgta acagccccca      780

gaactccaca gactctgtca gtgacattgt gcctgacagt cctttccccg gagcactcgg      840

cagtgacacc aggactgcag ggcagccaga ggggggcccc ggggctgatt ttggtcagtc      900

ctgcttccct gcagaggctg gcagagacac cctgtcaagg acagctgggg ctcagccctg      960

cgttggtacc gatactactg aaaaccttgg agttgctaat ggacaaatac ttgaatcctc     1020

gggtgagggc acagctacca acggggtgga gttgcacacc acggaaagca tagacttgga     1080

cccaaccaaa cccgagagtg catcacctcc tgctgacggc acgggctctg catcaggcac     1140

ccttcctgtc agccagccca agtcctgggc cagcctcttt catgattcta agccctcttc     1200

ctcctcgccg gtggcctatg tggaaactaa gtattcccct cccgccatat ctcccctggt     1260

ttctgaaaag caggttgaag tcaaagaagg gcttgttccg gtttcagagg atcctgtagc     1320

cataaagatt gcagagttgc tggagaatgt aaccctaatc cataaaccag tgtcgttgca     1380

accccgtggg ctgatcaata aagggaactg gtgctacatt aatgctacac tgcaggcatt     1440

ggttgcttgc ccgccgatgt accacctgat gaagttcatt cctctgtatt ccaaagtgca     1500

aaggccttgt acgtcaacac ccatgataga cagctttgtt cggctaatga atgagttcac     1560

taatatgcca gtacctccaa aaccccgaca agctcttgga gataaaatcg tgagggatat     1620

tcgccctgga gctgcctttg agcccacata tatttacaga ctcctgacag ttaacaagtc     1680

aagcctgtct gaaaagggtc gacaagaaga tgctgaggaa tacttaggct tcattctaaa     1740

tggacttcat gaggaaatgt tgaacctaaa gaagcttctc tcaccaagta atgaaaaact     1800

tacgatttcc aacggcccca aaaaccactc ggtcaatgaa gaagagcagg aagaacaagg     1860

tgaaggaagc gaggatgaat gggaacaagt gggcccccgg aacaagactt ccgtcacccg     1920

ccaggcggat tttgttcaga ctccaatcac cggcattttt ggtggacaca tcaggtctgt     1980

ggtttaccag cagagttcaa aagaatctgc cactttgcag ccatttttca cgttgcagtt     2040

ggatatccag tcagacaaga tacgcacagt ccaggatgca ctggagagct tggtggcaag     2100

agaatctgtc caaggttata ccacaaaaac caaacaagag gttgagataa gtcgaagagt     2160

gactctggaa aaactccctc ctgtcctcgt gctgcacctg aaacgattcg tttatgagaa     2220

gactggtggg tgccagaagc ttatcaaaaa tattgaatat cctgtggact tggaaattag     2280

taaagaactg ctttctccag gggttaaaaa taagaatttt aaatgccacc gaacctatcg     2340

gctctttgca gtggtctacc atcacggcaa cagtgcgacg ggcggccatt acactacaga     2400

cgtcttccag atcggtctga atggctggct gcgcatcgat gaccagacag tcaaggtgat     2460

caaccagtac caggtggtga aaccaactgc tgaacgcaca gcctacctcc tgtattaccg     2520

ccgagtggac ctgctgtaaa ccctgtgtgc gctgtgtgtg cgcccagtgc ccgcttcgta     2580

ggacaccacc tcacactcac ttcccgcctc tctttagtgg ctctttagag agaaactctt     2640

tctccctttg caaaaatggg ctagaatgaa aaggagatgc cttggggttc gtgcacaaca     2700

cagcttctgt tgactctaac ttccaaatca aaatcatttg gttgaaacag actgttgctt     2760

gattttagaa aatacacaaa aacccatatt tctgaaataa tgctgattcc tgagataaga     2820

aagtggattt gatccccagt ctcattgctt agtagaataa atcctgcacc agcaacaaca     2880

cttgtaaatt tgtgaaaatg aattttatct ttccttaaaa aagaaatttt ttaatccatc     2940

acacttttct tccctaccct ttagtttttg ataaatgata aaaatgagcc agttatcaaa     3000

gaagaactag ttcttacttc aaaagaaaaa taaacataaa aaataagttg ctggttccta     3060

acaggaaaaa ttttaataat tgtactgaga gaaactgctt acgtacacat tgcagatcaa     3120

atatttggag ttaaaatgtt agtctacata gatgggtgat tgtaacttta ttgccattaa     3180

aagatttcaa attgcattca tgcttctgtg tacacataat gaaaaatggg caaataatga     3240

agatctctcc ttcagtctgc tctgtttaat tctgctgtct gctcttctct aatgctgcgt     3300

ccctaattgt acacagttta gtgatatcta ggagtataaa gttgtcgccc atcaataaaa     3360

atcacaaagt tggtttaaaa aaaaaaaaaa aaaaaaaaa                            3399


<210>  525
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210>  526
<211>  2098
<212>  DNA
<213>  Homo sapiens

<400>  526
gctgaaggaa ctttttgtct ttaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa       60

ggaaagaaag aaagaaagaa agaaaggaag gaaggaagaa agaaagaaag tttgtccgag      120

tgatggaata cacctctgag gcttccattg ttaggtggga tcaggtgacc agagtgtggc      180

agctcctgga ttctgtgaaa gtaggcacag gatgttagca tcccatgttc actgctatgg      240

atgcctgtgt atatggctaa tacggaggct gctggatcta ttccttgaga gcaacacaca      300

gtactatcgg agcgtaatac caacagctca gtgcctggtg cttggcctca gaacatctca      360

gctgaagtcc cagcatgccc catgcctcca acttttaagc tcaacagtta atctcaaaat      420

tgtgcccaat taaaatgggc aggagaatgt atttccctct gcattgtcta cacgtgtgtt      480

ctatgtgact aggttttcct gacgtagttc ctcgaacacc actagtctgg actaaatgga      540

gaggttaaat attcaactct taatattcaa tacaaaagga gggaatcaag agatcaggaa      600

agataaaata tgtgttactt tgcaagattt tgtgagaaca aaaaaaaaaa tggaaggaag      660

agttctccct ccttggtttg gtacctcttt aaaaatgtta tacacaatgg gtttttaaat      720

gaaggagatg gatatatatt ttctaaatat tatggaatga gagaagcaac tgggcacatt      780

tggtattagc gcattcttgg ggcggagagg ggggggtcaa tcaatgtcta tgactttgct      840

ttagaaatta gaaaagattg ctatcaggat ttttaattca ccccgacaaa gttattggtc      900

atagcaaacc aaatttcaaa atgatcctct ctcagggcaa ttgttagcat tttccccact      960

ttgtagtttt ctgagattgt aacttttcac ggcagggtag ctgcagtgtc tcaggtctgc     1020

ctcacatagg agagaaggac tgggaggctt acctttcctt tgttgtagaa aactccgggc     1080

gcacggttcc ctttaaacag tttcactctt ctcagcccaa cctttctctc catttttgga     1140

aaatacctaa atcaacccag acacccaaca ccttcatctc tgaaagattt tggaatggct     1200

tgtagtctca ttgtgacacg gagtgaaagg tgaaggaaac ggttgcctat tttttaagca     1260

ttcctcgcaa ttttactcat tttactccaa actgcagtca aggaagcatt tttttttttt     1320

ttgcaccagc acgctgagct gggaagtgta caacaactgt accatgtctt ttgttgaagc     1380

ctcccgtgcg gctgtaattt aactgttact tggcaccact tggtagaaga cgcttcaaag     1440

cgtacagttc tgtaagaggt tgcccgcgag tttatataaa gtaattaatg attccccacc     1500

ccagcccagc caatgtgtat gtatggctat gtggaaatga tggcggtaca tcagcttaac     1560

ttatgggtaa tatatattta catcatgcat ttgatagaat ggcagacatt cggtgctttt     1620

gaaggcaaga tatgtacaca gcctaataga agaaacgtgg gcaggatcaa taaagctagg     1680

atagctgtaa tttctctgtg atttcgaatg atcgggcaac gccatacaaa tgcttctgtt     1740

tgtactctga gtccctatgc tttcgagtgg attcctcctg tttctcggat gtaaaaccgg     1800

gcgcccaggc attcagagtg cctgtgacac ccaggttttt atatattagc aggcaacttc     1860

ttcatcacaa gggcaggttt ctcaacactc ccttcttcct cgtggagccc atcagcgaag     1920

ttcagtgaaa tgaataacat aattggtggt tggttcaatc actaccagtc tagactagcc     1980

cagacgcatc aattagaggg gactgtcttt tagagggaga gtgtaaccga aacaagcagg     2040

gtattattga tactgatctt taaaagcgaa aatccagcct ggcaaaaaaa aaaaaaaa       2098


<210>  527
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  527

Met Leu Ala Ser His Val His Cys Tyr Gly Cys Leu Cys Ile Trp Leu 
1               5                   10                  15      


Ile Arg Arg Leu Leu Asp Leu Phe Leu Glu Ser Asn Thr Gln Tyr Tyr 
            20                  25                  30          


Arg Ser Val Ile Pro Thr Ala Gln Cys Leu Val Leu Gly Leu Arg Thr 
        35                  40                  45              


Ser Gln Leu Lys Ser Gln His Ala Pro Cys Leu Gln Leu Leu Ser Ser 
    50                  55                  60                  


Thr Val Asn Leu Lys Ile Val Pro Asn 
65                  70              


<210>  528
<211>  2984
<212>  DNA
<213>  Homo sapiens

<400>  528
gcagacggtt ccgggagccg cacggtcccc tctccttccc catcctctcc cctcccctct       60

ccgggttccc ccacccacag gagccttggg ccgaccactc ccccgatggc ctcagccacg      120

gaggaccccg ttctggagcg ttatttcaaa ggccacaaag ctgcgatcac ctccttggac      180

ctcagcccca acggcaagca acttgctact gcttcttggg atacctttct catgctatgg      240

aatttcaagc cacatgctag agcttacaga tatgtgggtc acaaggatgt tgtaaccagc      300

gtgcagtttt ctccacatgg aaacttattg gcgtctgcct cacgagacag aaccgtgaga      360

ctctggattc ctgataagag aggaaaattc tcagaattta aagctcatac agctccagtt      420

cgaagtgtag acttttcagc tgatggccag tttctagcta cagcttctga agacaaatcc      480

ataaaagtat ggagcatgta tcgccagcgc ttcctgtatt ccttgtatcg acatacacac      540

tgggtacgct gtgccaaatt ttcacccgat ggaagactaa ttgtgtcatg tagtgaggat      600

aaaactatta aaatttggga taccacaaat aagcaatgtg ttaataactt ctcagattcc      660

gttggatttg caaattttgt ggactttaac cctagtggta catgcatagc ttcagcaggt      720

tctgatcaaa ctgtgaaagt ctgggatgta agagtgaaca aattactaca gcattaccaa      780

gttcacagcg gtggagttaa ttgcatatca ttccatcctt cgggtaacta tctcatcaca      840

gcttcttcag atggtaccct taagattctg gacctcttag aaggaaggct catctataca      900

cttcaaggac atacgggacc tgtctttact gtttcatttt caaaaggtgg agagctattt      960

gcatcaggag gtgcagacac acaggtctta ttatggagga ctaactttga tgaattgcat     1020

tgtaaaggtc ttaccaaaag aaatctcaaa agattacatt ttgattcacc accacatctt     1080

cttgatatct acccaagaac accacatccc catgaggaaa aagttgagac tgtagaaatt     1140

aatccaaagc ttgaggtaat cgatttgcag atctctactc cccctgttat ggatatcctt     1200

tcttttgatt ctaccacaac aacagaaacc agtggtagga ctctgccaga caagggtgaa     1260

gaggcctgtg gatatttctt gaacccttcc ttaatgtcac cagaatgttt gccaacaacc     1320

acgaaaaaga aaacagaaga catgagtgac ctcccctgtg aaagtcaaag gagcatacct     1380

ctcgctgtga ctgatgcttt agagcatatt atggaacaac tcaatgtttt gacacagact     1440

gtttcaatct tggagcagcg actgactttg acagaggata agctgaaaga ctgccttgaa     1500

aatcagcaaa agcttttcag tgctgtccaa cagaaaagct gaataaaaaa ttcattttca     1560

tttgttgggc agaggcccaa taaatgaaca aatgtacata cactcaggaa ggtagtacaa     1620

gatactccat acaacacaac catgtgctat ttatcatggc atttcttaaa agggtgagca     1680

acagaacaaa aggcagaaaa ggcataccta aggactaatt taaacacata tcaatgtgaa     1740

ggactaattt aaattactat catttatgat tgcagtaata aagtgataag cattcaagca     1800

actctgtatt ttcctcatat tattttaaat gtccattttc atttataggc caaatcctgc     1860

caggaaagta accagatctc tggatttcac tgttaagtca tttcagattg accatattca     1920

gacagtcatg gggtgaaata attcacttac ctccaaaata gcgtcctata tgccaataat     1980

gagttattga tctgactagt tgtatgtctt tctgttcaaa atagaaatta tcctttctta     2040

ctaatgcctt gaaagaatga acaaataaaa attcccagac cacagaattt ccacagcaag     2100

aatacactta ttttaattaa caatagcaca gatatagcat agggcagtgg gttttttagt     2160

taatttatgg cgtactttgt ttatccattg gccaacctga aggaaatgaa actcacctat     2220

ctttctatca cagatgaatg tgctagatga atgatttggg ttgtatctga tcatggttca     2280

caaaaattat gttagtgtgt tttcagtatg ctaaaaagtc agagtgatac aaaagtgata     2340

tttaaaaata tacacacatg tatgtacaca tgcttcagaa atattgttgc ttagggtgat     2400

ttgggcagct aaatagtaag tactttttaa aatttttgca tcatcatctt cctatttaat     2460

gaattgtgat ttaaaacaaa atgaaaataa gccaggtatt ctaaaagatc ctggatacaa     2520

attaagaatt ttgctttatt ttaaaccaaa ttgagattaa attgaagaaa agcaagcaaa     2580

ttaatttcag cttgattatc aacctgtatc aagaacaaaa atgggaggag gtgtccacat     2640

ttatggtgtg tataggtaac atggggaaaa tgctattctg tgttttggaa aagaagaaat     2700

agtgccgtcc tatttatttc tatatttaga aatttttctc aaagaaattt caattgtatc     2760

tatgagatgg gtttctaagt atcttattgt gtgttataag tgccctttaa tatcatacta     2820

agtgtgagct tctggacatt ttcaagagct tacaaaaact aagtggcatt gtatttttat     2880

aaccccattg agaagactaa gtaagaaatg aaatgtccta tcaattttat tttgtcatgc     2940

ttcaaacaat aaagacattt ctgctttaaa aaaaaaaaaa aaaa                      2984


<210>  529
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  529

Met Ala Ser Ala Thr Glu Asp Pro Val Leu Glu Arg Tyr Phe Lys Gly 
1               5                   10                  15      


His Lys Ala Ala Ile Thr Ser Leu Asp Leu Ser Pro Asn Gly Lys Gln 
            20                  25                  30          


Leu Ala Thr Ala Ser Trp Asp Thr Phe Leu Met Leu Trp Asn Phe Lys 
        35                  40                  45              


Pro His Ala Arg Ala Tyr Arg Tyr Val Gly His Lys Asp Val Val Thr 
    50                  55                  60                  


Ser Val Gln Phe Ser Pro His Gly Asn Leu Leu Ala Ser Ala Ser Arg 
65                  70                  75                  80  


Asp Arg Thr Val Arg Leu Trp Ile Pro Asp Lys Arg Gly Lys Phe Ser 
                85                  90                  95      


Glu Phe Lys Ala His Thr Ala Pro Val Arg Ser Val Asp Phe Ser Ala 
            100                 105                 110         


Asp Gly Gln Phe Leu Ala Thr Ala Ser Glu Asp Lys Ser Ile Lys Val 
        115                 120                 125             


Trp Ser Met Tyr Arg Gln Arg Phe Leu Tyr Ser Leu Tyr Arg His Thr 
    130                 135                 140                 


His Trp Val Arg Cys Ala Lys Phe Ser Pro Asp Gly Arg Leu Ile Val 
145                 150                 155                 160 


Ser Cys Ser Glu Asp Lys Thr Ile Lys Ile Trp Asp Thr Thr Asn Lys 
                165                 170                 175     


Gln Cys Val Asn Asn Phe Ser Asp Ser Val Gly Phe Ala Asn Phe Val 
            180                 185                 190         


Asp Phe Asn Pro Ser Gly Thr Cys Ile Ala Ser Ala Gly Ser Asp Gln 
        195                 200                 205             


Thr Val Lys Val Trp Asp Val Arg Val Asn Lys Leu Leu Gln His Tyr 
    210                 215                 220                 


Gln Val His Ser Gly Gly Val Asn Cys Ile Ser Phe His Pro Ser Gly 
225                 230                 235                 240 


Asn Tyr Leu Ile Thr Ala Ser Ser Asp Gly Thr Leu Lys Ile Leu Asp 
                245                 250                 255     


Leu Leu Glu Gly Arg Leu Ile Tyr Thr Leu Gln Gly His Thr Gly Pro 
            260                 265                 270         


Val Phe Thr Val Ser Phe Ser Lys Gly Gly Glu Leu Phe Ala Ser Gly 
        275                 280                 285             


Gly Ala Asp Thr Gln Val Leu Leu Trp Arg Thr Asn Phe Asp Glu Leu 
    290                 295                 300                 


His Cys Lys Gly Leu Thr Lys Arg Asn Leu Lys Arg Leu His Phe Asp 
305                 310                 315                 320 


Ser Pro Pro His Leu Leu Asp Ile Tyr Pro Arg Thr Pro His Pro His 
                325                 330                 335     


Glu Glu Lys Val Glu Thr Val Glu Ile Asn Pro Lys Leu Glu Val Ile 
            340                 345                 350         


Asp Leu Gln Ile Ser Thr Pro Pro Val Met Asp Ile Leu Ser Phe Asp 
        355                 360                 365             


Ser Thr Thr Thr Thr Glu Thr Ser Gly Arg Thr Leu Pro Asp Lys Gly 
    370                 375                 380                 


Glu Glu Ala Cys Gly Tyr Phe Leu Asn Pro Ser Leu Met Ser Pro Glu 
385                 390                 395                 400 


Cys Leu Pro Thr Thr Thr Lys Lys Lys Thr Glu Asp Met Ser Asp Leu 
                405                 410                 415     


Pro Cys Glu Ser Gln Arg Ser Ile Pro Leu Ala Val Thr Asp Ala Leu 
            420                 425                 430         


Glu His Ile Met Glu Gln Leu Asn Val Leu Thr Gln Thr Val Ser Ile 
        435                 440                 445             


Leu Glu Gln Arg Leu Thr Leu Thr Glu Asp Lys Leu Lys Asp Cys Leu 
    450                 455                 460                 


Glu Asn Gln Gln Lys Leu Phe Ser Ala Val Gln Gln Lys Ser 
465                 470                 475             


<210>  530
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  530
aaagagcagg cgaaagccac ggcgtctgcg tttgcaatgc atgctggtcc gtgtagttct       60

cagcctgaca ccgtcgttcc cagaacccag cgcgctctgt gctggcgggc gcagaggcct      120

cccaggagga gagcaaggac ctggcagggg ctgctgagga ggaggagagc gggctgcccg      180

gggccgggcc tggctcctgt gcttttgggg aggagattcc catggatggg gagcctcctg      240

cctcctcggg cctggggctc ccagactaca cgtctggcgt cagcttccac gaccaggctg      300

acctccctga gacagaggac ttccaagccg ggctctatgt gactgagtct ccccagcccc      360

aggaggctga ggctgtgagc ctgggccggc tgagtgacaa gagcagcacc agcgagacct      420

ccctgggtga ggagcgggct ccagacgagg ggggtgcccc cgtggacaag agcagccttc      480

gatcaggtga cagcagccag gacttgaagc aaagcgaggg ctccgaggag gaagaggagg      540

aggaggacag ctgcgtggtg ctagaggagg aggaggggga gcaggaggag gtcaccgggg      600

catctgagct cactctgtct gacacggtgc tgtccatgga gacggttgtg gccggcggca      660

gtgggggaga tggagaagaa gaggaggagg cactgcctga gcagtcagaa ggcaaagaac      720

agaagatcct ccttgataca gcctgcaaga tggtccgctg gctgtctgcc aagctcggcc      780

ccacagtggc ctctcgccac gtggcccgga acctgctccg cctgctgacg tcttgttatg      840

ttggacccac tcggcagcag ttcacagtga gcagtggcga gagcccaccg ctgagcgccg      900

gcaacatcta ccagaagagg ccggtcctgg gcgacatcgt gtcagggcct gtgctcagct      960

gcctcctcca catcgcccgc ctgtatgggg agcctgtcct cacctaccag tacctgccct     1020

acatcagcta cctggtggcc ccagggagtg cctcaggccc cagccgactg aacagccgta     1080

aggaggcggg gctgctggcc gcggtgacgc tgactcagaa gatcatcgtg tacctctcag     1140

acaccacact catggacatc ctgccccgga tcagccatga ggtcctgctg cccgtgctca     1200

gcttcctcac ctccctcgtc acggggttcc caagtggggc ccaggctcgg accatcctgt     1260

gtgtgaaaac catcagcctc atcgccctca tctgcctgcg cattggacag gagatggtcc     1320

agcagcacct gagcgagccc gtggccacct ttttccaggt cttctctcag ctgcatgagc     1380

ttcggcaaca ggatctgaag ctggaccctg cgggccgtgg tgagggccag ctgccacagg     1440

tggtcttctc tgatgggcag cagcggcccg tggaccccgc cctgctggac gagctgcaga     1500

aggtgttcac cctggagatg gcatacacaa tctacgtgcc cttctcctgc ctgttgggtg     1560

acatcatccg gaaaatcatc cccaaccacg agctggttgg ggagctggcg gcgctgtact     1620

tggagagcat cagccccagc agtcgcaacc ctgccagcgt ggagcccacc atgcccggca     1680

ccgggcccga gtgggacccc catggtgggg gctgccctca ggatgacggc cactcaggga     1740

cctttgggag cgtcctggtg gggaaccgca ttcagatccc caatgactct cggcctgaga     1800

accccggacc actgggcccc atctcggggg tgggtggcgg gggcctgggc agcgggagcg     1860

acgacaacgc cctgaagcag gagctgccgc ggagcgtgca cgggctgagc ggaaactggc     1920

tggcgtactg gcagtacgag atcggcgtga gccagcagga tgcccacttt cacttccacc     1980

agatccgcct gcagagcttc ccgggccact cgggggccgt caagtgcgtg gcacccctaa     2040

gcagcgagga cttcttcctg agcggcagca aggatcgtac cgtgcgcctc tggccgctgt     2100

acaactacgg cgacgggacc agcgagacgg ccccacgcct cgtctacacc cagcaccgca     2160

agagcgtctt cttcgtgggc cagcttgagg ccccgcagca cgtggtgagc tgtgacgggg     2220

ctgtgcacgt ctgggacccc ttcacaggga agacccttcg cacagtggag ccgctggaca     2280

gccgggtgcc cctgactgcg gtggctgtca tgcccgcccc ccacaccagc atcaccatgg     2340

ccagctctga ctctaccctg cgctttgtgg actgcaggaa gcctggtctg cagcacgagt     2400

tccgactggg cggtgggctg aaccctgggc ttgtccgtgc cctggccatc agccccagtg     2460

gccgtagtgt cgtggccggc ttctcctcag gcttcatggt gctcctggac acccgcacag     2520

gcctggttct gcgaggctgg ccagcccacg agggggacat tctgcagatc aaggcggtgg     2580

agggcagcgt cctggtcagc tcctcctctg accattcctt gaccgtctgg aaggagctgg     2640

agcagaagcc cacccatcac tacaagtcag catccgaccc catccacacc tttgacctgt     2700

acggcagcga ggtggtcact ggcaccgtgt ccaacaagat tggcgtctgc tccctgcttg     2760

agccaccctc gcaggccacc acgaagctca gctctgagaa cttccgcggc acgctcacca     2820

gcctggcctt gctgcccact aaacgccacc tcctgctggg ctcagacaac ggggttatcc     2880

gcctcctggc atagactgag gcaggagctg gccgggcaag ggtgggaaga catctgcggg     2940

cgcgtgtcca ctcaccctgt tccctgagca gcagctccct ccagggaggc cctgggtccc     3000

acgccctggg tgcccacatg gcctgccaac tagggcctgc aaatggagtg ggggagtcct     3060

ggcccctgaa tcaccagagc caccaagcct gccagagggg tctcattcat ggcttgggga     3120

cacagggctc ctagcaagca ggaagttaag agcaggagga agcgttgcta ccttcacttc     3180

tccccagctc tgccctctgg gtccacatga ggacagggaa gctcgggaag gggaagggag     3240

actggccctg cccagccggt ctctagcccc tcagcccccg ctgggcactc tctgtcccat     3300

ccctctagga cagggaagct ggcctggtcc agggcactga tggtgcttgg attccagcct     3360

aaggaaggct ggccgtggtc caggagttaa gggcttgggt ctggggttta agtggccacc     3420

catccaggcc ctggccagtg tgggaccggg acgggaagga agaaggaggc taggagcagg     3480

gggaaaaggt gcacttggcc agtggcgcct gccaggagtg agtccatgcg ttgtctgccc     3540

acccctacca cagtgtttgt gccttcagct gagggggcag cctctgggcc ctgaacccct     3600

gctggggctc cacgaccctg agagaagggg tgagaagaat catctctgca cctcgggtct     3660

ctgccagagg aagacttaag catccctgcg acctcacatt ctagacagag atgaggtcca     3720

ggggttggcc cctgctgcct tctcacaatt tgcaatagat gtaaatagga ccaataaatc     3780

ctttggaaga gcca                                                       3794


<210>  531
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  531

Met Asp Gly Glu Pro Pro Ala Ser Ser Gly Leu Gly Leu Pro Asp Tyr 
1               5                   10                  15      


Thr Ser Gly Val Ser Phe His Asp Gln Ala Asp Leu Pro Glu Thr Glu 
            20                  25                  30          


Asp Phe Gln Ala Gly Leu Tyr Val Thr Glu Ser Pro Gln Pro Gln Glu 
        35                  40                  45              


Ala Glu Ala Val Ser Leu Gly Arg Leu Ser Asp Lys Ser Ser Thr Ser 
    50                  55                  60                  


Glu Thr Ser Leu Gly Glu Glu Arg Ala Pro Asp Glu Gly Gly Ala Pro 
65                  70                  75                  80  


Val Asp Lys Ser Ser Leu Arg Ser Gly Asp Ser Ser Gln Asp Leu Lys 
                85                  90                  95      


Gln Ser Glu Gly Ser Glu Glu Glu Glu Glu Glu Glu Asp Ser Cys Val 
            100                 105                 110         


Val Leu Glu Glu Glu Glu Gly Glu Gln Glu Glu Val Thr Gly Ala Ser 
        115                 120                 125             


Glu Leu Thr Leu Ser Asp Thr Val Leu Ser Met Glu Thr Val Val Ala 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asp Gly Glu Glu Glu Glu Glu Ala Leu Pro Glu 
145                 150                 155                 160 


Gln Ser Glu Gly Lys Glu Gln Lys Ile Leu Leu Asp Thr Ala Cys Lys 
                165                 170                 175     


Met Val Arg Trp Leu Ser Ala Lys Leu Gly Pro Thr Val Ala Ser Arg 
            180                 185                 190         


His Val Ala Arg Asn Leu Leu Arg Leu Leu Thr Ser Cys Tyr Val Gly 
        195                 200                 205             


Pro Thr Arg Gln Gln Phe Thr Val Ser Ser Gly Glu Ser Pro Pro Leu 
    210                 215                 220                 


Ser Ala Gly Asn Ile Tyr Gln Lys Arg Pro Val Leu Gly Asp Ile Val 
225                 230                 235                 240 


Ser Gly Pro Val Leu Ser Cys Leu Leu His Ile Ala Arg Leu Tyr Gly 
                245                 250                 255     


Glu Pro Val Leu Thr Tyr Gln Tyr Leu Pro Tyr Ile Ser Tyr Leu Val 
            260                 265                 270         


Ala Pro Gly Ser Ala Ser Gly Pro Ser Arg Leu Asn Ser Arg Lys Glu 
        275                 280                 285             


Ala Gly Leu Leu Ala Ala Val Thr Leu Thr Gln Lys Ile Ile Val Tyr 
    290                 295                 300                 


Leu Ser Asp Thr Thr Leu Met Asp Ile Leu Pro Arg Ile Ser His Glu 
305                 310                 315                 320 


Val Leu Leu Pro Val Leu Ser Phe Leu Thr Ser Leu Val Thr Gly Phe 
                325                 330                 335     


Pro Ser Gly Ala Gln Ala Arg Thr Ile Leu Cys Val Lys Thr Ile Ser 
            340                 345                 350         


Leu Ile Ala Leu Ile Cys Leu Arg Ile Gly Gln Glu Met Val Gln Gln 
        355                 360                 365             


His Leu Ser Glu Pro Val Ala Thr Phe Phe Gln Val Phe Ser Gln Leu 
    370                 375                 380                 


His Glu Leu Arg Gln Gln Asp Leu Lys Leu Asp Pro Ala Gly Arg Gly 
385                 390                 395                 400 


Glu Gly Gln Leu Pro Gln Val Val Phe Ser Asp Gly Gln Gln Arg Pro 
                405                 410                 415     


Val Asp Pro Ala Leu Leu Asp Glu Leu Gln Lys Val Phe Thr Leu Glu 
            420                 425                 430         


Met Ala Tyr Thr Ile Tyr Val Pro Phe Ser Cys Leu Leu Gly Asp Ile 
        435                 440                 445             


Ile Arg Lys Ile Ile Pro Asn His Glu Leu Val Gly Glu Leu Ala Ala 
    450                 455                 460                 


Leu Tyr Leu Glu Ser Ile Ser Pro Ser Ser Arg Asn Pro Ala Ser Val 
465                 470                 475                 480 


Glu Pro Thr Met Pro Gly Thr Gly Pro Glu Trp Asp Pro His Gly Gly 
                485                 490                 495     


Gly Cys Pro Gln Asp Asp Gly His Ser Gly Thr Phe Gly Ser Val Leu 
            500                 505                 510         


Val Gly Asn Arg Ile Gln Ile Pro Asn Asp Ser Arg Pro Glu Asn Pro 
        515                 520                 525             


Gly Pro Leu Gly Pro Ile Ser Gly Val Gly Gly Gly Gly Leu Gly Ser 
    530                 535                 540                 


Gly Ser Asp Asp Asn Ala Leu Lys Gln Glu Leu Pro Arg Ser Val His 
545                 550                 555                 560 


Gly Leu Ser Gly Asn Trp Leu Ala Tyr Trp Gln Tyr Glu Ile Gly Val 
                565                 570                 575     


Ser Gln Gln Asp Ala His Phe His Phe His Gln Ile Arg Leu Gln Ser 
            580                 585                 590         


Phe Pro Gly His Ser Gly Ala Val Lys Cys Val Ala Pro Leu Ser Ser 
        595                 600                 605             


Glu Asp Phe Phe Leu Ser Gly Ser Lys Asp Arg Thr Val Arg Leu Trp 
    610                 615                 620                 


Pro Leu Tyr Asn Tyr Gly Asp Gly Thr Ser Glu Thr Ala Pro Arg Leu 
625                 630                 635                 640 


Val Tyr Thr Gln His Arg Lys Ser Val Phe Phe Val Gly Gln Leu Glu 
                645                 650                 655     


Ala Pro Gln His Val Val Ser Cys Asp Gly Ala Val His Val Trp Asp 
            660                 665                 670         


Pro Phe Thr Gly Lys Thr Leu Arg Thr Val Glu Pro Leu Asp Ser Arg 
        675                 680                 685             


Val Pro Leu Thr Ala Val Ala Val Met Pro Ala Pro His Thr Ser Ile 
    690                 695                 700                 


Thr Met Ala Ser Ser Asp Ser Thr Leu Arg Phe Val Asp Cys Arg Lys 
705                 710                 715                 720 


Pro Gly Leu Gln His Glu Phe Arg Leu Gly Gly Gly Leu Asn Pro Gly 
                725                 730                 735     


Leu Val Arg Ala Leu Ala Ile Ser Pro Ser Gly Arg Ser Val Val Ala 
            740                 745                 750         


Gly Phe Ser Ser Gly Phe Met Val Leu Leu Asp Thr Arg Thr Gly Leu 
        755                 760                 765             


Val Leu Arg Gly Trp Pro Ala His Glu Gly Asp Ile Leu Gln Ile Lys 
    770                 775                 780                 


Ala Val Glu Gly Ser Val Leu Val Ser Ser Ser Ser Asp His Ser Leu 
785                 790                 795                 800 


Thr Val Trp Lys Glu Leu Glu Gln Lys Pro Thr His His Tyr Lys Ser 
                805                 810                 815     


Ala Ser Asp Pro Ile His Thr Phe Asp Leu Tyr Gly Ser Glu Val Val 
            820                 825                 830         


Thr Gly Thr Val Ser Asn Lys Ile Gly Val Cys Ser Leu Leu Glu Pro 
        835                 840                 845             


Pro Ser Gln Ala Thr Thr Lys Leu Ser Ser Glu Asn Phe Arg Gly Thr 
    850                 855                 860                 


Leu Thr Ser Leu Ala Leu Leu Pro Thr Lys Arg His Leu Leu Leu Gly 
865                 870                 875                 880 


Ser Asp Asn Gly Val Ile Arg Leu Leu Ala 
                885                 890 


<210>  532
<211>  6869
<212>  DNA
<213>  Homo sapiens

<400>  532
gcggccgcct ccgccccagc ccctgtcccg cgcccatccc agccccgccg gcctggcacc       60

ccggaagccg tcgccagcag ggccgtggct gggctcagcc ccgcgctgcc cccgggcggc      120

ctggaggaga tggcccaggg cagcgggggg cgggaaggcg ctctcagaac cccggccggg      180

ggctggcatt ccccgccaag cccagacatg caggagctgc tccggagcgt ggagagggac      240

ctgagcatcg atcccaggca gctggctccg gccccggggg gcacccacgt ggtggcccta      300

gtgcctgcgc gctggctggc cagcctccgc gatcgccggc tgcccctggg accctgtccc      360

cgcgcagagg gcctgggaga agcggaagtc aggactctcc tgcagcgctc tgtgcaaagg      420

ctgcctgccg gctggacgcg cgtggaggtg catgggctgc ggaagcggag actgtcctac      480

cctctgggcg ggggcctgcc ctttgaggac gggtcctgcg gccctgagac cctcactcgc      540

ttcatgcagg aggttgccgc ccagaattat cgcaacctgt ggcgccatgc ataccacact      600

tacggccagc cgtacagtca cagccctgcc ccctcagctg tccctgcctt ggactcagta      660

cggcaggctc tgcagagggt ctatggttgc tccttcctgc cagtgggtga aactacccaa      720

tgcccttcat atgccagaga aggcccctgc ccccctcggg gcagccctgc ttgccctagt      780

cttttacggg ctgaggcctt gctggagtcg ccggagatgc tgtatgtggt acacccttac      840

gtacagttct ccctacatga cgtggtcacc ttcagccctg ccaagctgac caacagccag      900

gccaaggtgc tgttcattct cttccgcgtg ctgagggcta tggacgcctg tcaccgccag      960

gggctggcgt gtggggccct gtctttgtat cacatcgcag tggatgagaa gctttgcagc     1020

gagctgcgac tggacctgag tgcttatgag aggcccgagg aggacgagaa tgaggaggcc     1080

cctgtggcaa gggatgaggc gggcattgtg tctcaagagg agcagggagg gcaacctggg     1140

caacccactg gccaggagga acttcggagc ctcgtgctag attgggtcca cggccgcatc     1200

agcaacttcc actacctcat gcagctgaat cggttggcag gtcggcggca gggggacccc     1260

aactaccacc ccgtgctgcc ctgggtggtg gacttcacta cgccccatgg gcgcttccga     1320

gacctgcgca agtccaagtt ccgcctcaac aagggggata agcaactgga cttcacgtat     1380

gagatgacac ggcaggcatt cgtagcaggc ggggcgggcg gcggggaacc ccctcatgtt     1440

ccccaccaca tctcagacgt gctctccgac atcacgtact atgtgtacaa ggctcggcgc     1500

acgcctcggt cggtgctctg cggacacgtc cgcgcgcagt gggagcccca tgagtatccg     1560

gccagcatgg agcggatgca gaactggacc ccggatgagt gcattccgga gttctacacc     1620

gatccctcta tcttccgctc catccacccc gacatgcctg acctggatgt gccagcctgg     1680

tgcagctcca gccaggagtt cgtagctgcc caccgagccc tgctggagag ccgcgaggta     1740

tcccgggacc tgcaccattg gatcgacctc acgtttggct ataaactcca gggtaaggag     1800

gctgtcaagg aaaagaatgt gtgtctgcac ctggtggacg cccacactca cctggccagc     1860

tacggggtgg tgcagctctt cgatcagcca cacccccagc gcctggctgg ggctcctgcc     1920

cttgcccccg agcctcccct catccccaag ctgttggtcc agaccatcca ggagaccaca     1980

ggccgggagg acttcacgga aaacccggga cagcttccaa atggagtggg ccggccagtt     2040

ttagaggcca ctccctgtga ggctagctgg accagagaca ggccggtggc aggagaagac     2100

gacttggaac aggccacaga agctctggat tccatttccc ttgctgggaa agcaggtgac     2160

cagctgggct cctccagtca agcgtcccct ggacttctct ctttctcagt ggcctcagcc     2220

tcccgtccag gccgcaggaa taaagctgct ggggcagacc ctggggaggg tgaggagggg     2280

aggattcttc ttcccgaggg cttcaatccc atgcaggccc tggaggagct ggagaaaacg     2340

ggcaacttct tggccaaagg cctagggggc ctgttggagg tgcctgagca gccccgggtc     2400

cagccggctg tgccactgca gtgcctactc cacagggaca tgcaggcgct gggtgtccta     2460

ttggcagaga tggtgtttgc caccagggtg cggacgctgc agcccgatgc acctttgtgg     2520

gtacgcttcc aggctgtccg agggctctgc acgcgccacc ccaaggaggt ccctgtgtct     2580

ttgcagcccg tgctggacac actcctgcag atgagtggcc ccgaagtccc catgggagca     2640

gagaggggca agctggacca actgtttgag tacaggcctg tctcccaggg cctgccccca     2700

ccctgcccaa gccagcttct cagccccttc agctccgtgg ttcccttccc accctacttc     2760

ccggcactgc acagattcat cctcctgtac caggcaaggc gtgtggagga cgaggcccag     2820

gggcgcgagc tggtgtttgc tctgtggcag cagctgggcg cggtgctgaa ggacatcacc     2880

cctgagggcc tggagatcct gctgcccttc gtgctctcac tcatgtccga ggagcacaca     2940

gctgtgtaca cggcctggta tctgtttgag cctgttgcca aggcactggg ccccaaaaat     3000

gccaataagt acctcctgaa gccgctcatt ggtgcctacg agagcccctg ccagctacac     3060

ggccgcttct acctgtacac ggactgcttt gtggcccagc tgatggtgcg gctgggcctg     3120

caggcatttc tcactcacct gctgccccat gtcctgcagg tgctggcggg cgcagaggcc     3180

tcccaggagg agagcaagga cctggcaggg gctgctgagg aggaggagag cgggctgccc     3240

ggggccgggc ctggctcctg tgcttttggg gaggagattc ccatggatgg ggagcctcct     3300

gcctcctcgg gcctggggct cccagactac acgtctggcg tcagcttcca cgaccaggct     3360

gacctccctg agacagagga cttccaagcc gggctctatg tgactgagtc tccccagccc     3420

caggaggctg aggctgtgag cctgggccgg ctgagtgaca agagcagcac cagcgagacc     3480

tccctgggtg aggagcgggc tccagacgag gggggtgccc ccgtggacaa gagcagcctt     3540

cgatcaggtg acagcagcca ggacttgaag caaagcgagg gctccgagga ggaagaggag     3600

gaggaggaca gctgcgtggt gctagaggag gaggaggggg agcaggagga ggtcaccggg     3660

gcatctgagc tcactctgtc tgacacggtg ctgtccatgg agacggttgt ggccggcggc     3720

agtgggggag atggagaaga agaggaggag gcactgcctg agcagtcaga aggcaaagaa     3780

cagaagatcc tccttgatac agcctgcaag atggtccgct ggctgtctgc caagctcggc     3840

cccacagtgg cctctcgcca cgtggcccgg aacctgctcc gcctgctgac gtcttgttat     3900

gttggaccca ctcggcagca gttcacagtg agcagtggcg agagcccacc gctgagcgcc     3960

ggcaacatct accagaagag gccggtcctg ggcgacatcg tgtcagggcc tgtgctcagc     4020

tgcctcctcc acatcgcccg cctgtatggg gagcctgtcc tcacctacca gtacctgccc     4080

tacatcagct acctggtggc cccagggagt gcctcaggcc ccagccgact gaacagccgt     4140

aaggaggcgg ggctgctggc cgcggtgacg ctgactcaga agatcatcgt gtacctctca     4200

gacaccacac tcatggacat cctgccccgg atcagccatg aggtcctgct gcccgtgctc     4260

agcttcctca cctccctcgt cacggggttc ccaagtgggg cccaggctcg gaccatcctg     4320

tgtgtgaaaa ccatcagcct catcgccctc atctgcctgc gcattggaca ggagatggtc     4380

cagcagcacc tgagcgagcc cgtggccacc tttttccagg tcttctctca gctgcatgag     4440

cttcggcaac aggatctgaa gctggaccct gcgggccgtg gtgagggcca gctgccacag     4500

gtggtcttct ctgatgggca gcagcggccc gtggaccccg ccctgctgga cgagctgcag     4560

aaggtgttca ccctggagat ggcatacaca atctacgtgc ccttctcctg cctgttgggt     4620

gacatcatcc ggaaaatcat ccccaaccac gagctggttg gggagctggc ggcgctgtac     4680

ttggagagca tcagccccag cagtcgcaac cctgccagcg tggagcccac catgcccggc     4740

accgggcccg agtgggaccc ccatggtggg ggctgccctc aggatgacgg ccactcaggg     4800

acctttggga gcgtcctggt ggggaaccgc attcagatcc ccaatgactc tcggcctgag     4860

aaccccggac cactgggccc catctcgggg gtgggtggcg ggggcctggg cagcgggagc     4920

gacgacaacg ccctgaagca ggagctgccg cggagcgtgc acgggctgag cggaaactgg     4980

ctggcgtact ggcagtacga gatcggcgtg agccagcagg atgcccactt tcacttccac     5040

cagatccgcc tgcagagctt cccgggccac tcgggggccg tcaagtgcgt ggcaccccta     5100

agcagcgagg acttcttcct gagcggcagc aaggatcgta ccgtgcgcct ctggccgctg     5160

tacaactacg gcgacgggac cagcgagacg gccccacgcc tcgtctacac ccagcaccgc     5220

aagagcgtct tcttcgtggg ccagcttgag gccccgcagc acgtggtgag ctgtgacggg     5280

gctgtgcacg tctgggaccc cttcacaggg aagacccttc gcacagtgga gccgctggac     5340

agccgggtgc ccctgactgc ggtggctgtc atgcccgccc cccacaccag catcaccatg     5400

gccagctctg actctaccct gcgctttgtg gactgcagga agcctggtct gcagcacgag     5460

ttccgactgg gcggtgggct gaaccctggg cttgtccgtg ccctggccat cagccccagt     5520

ggccgtagtg tcgtggccgg cttctcctca ggcttcatgg tgctcctgga cacccgcaca     5580

ggcctggttc tgcgaggctg gccagcccac gagggggaca ttctgcagat caaggcggtg     5640

gagggcagcg tcctggtcag ctcctcctct gaccattcct tgaccgtctg gaaggagctg     5700

gagcagaagc ccacccatca ctacaagtca gcatccgacc ccatccacac ctttgacctg     5760

tacggcagcg aggtggtcac tggcaccgtg tccaacaaga ttggcgtctg ctccctgctt     5820

gagccaccct cgcaggccac cacgaagctc agctctgaga acttccgcgg cacgctcacc     5880

agcctggcct tgctgcccac taaacgccac ctcctgctgg gctcagacaa cggggttatc     5940

cgcctcctgg catagactga ggcaggagct ggccgggcaa gggtgggaag acatctgcgg     6000

gcgcgtgtcc actcaccctg ttccctgagc agcagctccc tccagggagg ccctgggtcc     6060

cacgccctgg gtgcccacat ggcctgccaa ctagggcctg caaatggagt gggggagtcc     6120

tggcccctga atcaccagag ccaccaagcc tgccagaggg gtctcattca tggcttgggg     6180

acacagggct cctagcaagc aggaagttaa gagcaggagg aagcgttgct accttcactt     6240

ctccccagct ctgccctctg ggtccacatg aggacaggga agctcgggaa ggggaaggga     6300

gactggccct gcccagccgg tctctagccc ctcagccccc gctgggcact ctctgtccca     6360

tccctctagg acagggaagc tggcctggtc cagggcactg atggtgcttg gattccagcc     6420

taaggaaggc tggccgtggt ccaggagtta agggcttggg tctggggttt aagtggccac     6480

ccatccaggc cctggccagt gtgggaccgg gacgggaagg aagaaggagg ctaggagcag     6540

ggggaaaagg tgcacttggc cagtggcgcc tgccaggagt gagtccatgc gttgtctgcc     6600

cacccctacc acagtgtttg tgccttcagc tgagggggca gcctctgggc cctgaacccc     6660

tgctggggct ccacgaccct gagagaaggg gtgagaagaa tcatctctgc acctcgggtc     6720

tctgccagag gaagacttaa gcatccctgc gacctcacat tctagacaga gatgaggtcc     6780

aggggttggc ccctgctgcc ttctcacaat ttgcaataga tgtaaatagg accaataaat     6840

cctttggaag agccatgggg tgaactgag                                       6869


<210>  533
<211>  1941
<212>  PRT
<213>  Homo sapiens

<400>  533

Met Ala Gln Gly Ser Gly Gly Arg Glu Gly Ala Leu Arg Thr Pro Ala 
1               5                   10                  15      


Gly Gly Trp His Ser Pro Pro Ser Pro Asp Met Gln Glu Leu Leu Arg 
            20                  25                  30          


Ser Val Glu Arg Asp Leu Ser Ile Asp Pro Arg Gln Leu Ala Pro Ala 
        35                  40                  45              


Pro Gly Gly Thr His Val Val Ala Leu Val Pro Ala Arg Trp Leu Ala 
    50                  55                  60                  


Ser Leu Arg Asp Arg Arg Leu Pro Leu Gly Pro Cys Pro Arg Ala Glu 
65                  70                  75                  80  


Gly Leu Gly Glu Ala Glu Val Arg Thr Leu Leu Gln Arg Ser Val Gln 
                85                  90                  95      


Arg Leu Pro Ala Gly Trp Thr Arg Val Glu Val His Gly Leu Arg Lys 
            100                 105                 110         


Arg Arg Leu Ser Tyr Pro Leu Gly Gly Gly Leu Pro Phe Glu Asp Gly 
        115                 120                 125             


Ser Cys Gly Pro Glu Thr Leu Thr Arg Phe Met Gln Glu Val Ala Ala 
    130                 135                 140                 


Gln Asn Tyr Arg Asn Leu Trp Arg His Ala Tyr His Thr Tyr Gly Gln 
145                 150                 155                 160 


Pro Tyr Ser His Ser Pro Ala Pro Ser Ala Val Pro Ala Leu Asp Ser 
                165                 170                 175     


Val Arg Gln Ala Leu Gln Arg Val Tyr Gly Cys Ser Phe Leu Pro Val 
            180                 185                 190         


Gly Glu Thr Thr Gln Cys Pro Ser Tyr Ala Arg Glu Gly Pro Cys Pro 
        195                 200                 205             


Pro Arg Gly Ser Pro Ala Cys Pro Ser Leu Leu Arg Ala Glu Ala Leu 
    210                 215                 220                 


Leu Glu Ser Pro Glu Met Leu Tyr Val Val His Pro Tyr Val Gln Phe 
225                 230                 235                 240 


Ser Leu His Asp Val Val Thr Phe Ser Pro Ala Lys Leu Thr Asn Ser 
                245                 250                 255     


Gln Ala Lys Val Leu Phe Ile Leu Phe Arg Val Leu Arg Ala Met Asp 
            260                 265                 270         


Ala Cys His Arg Gln Gly Leu Ala Cys Gly Ala Leu Ser Leu Tyr His 
        275                 280                 285             


Ile Ala Val Asp Glu Lys Leu Cys Ser Glu Leu Arg Leu Asp Leu Ser 
    290                 295                 300                 


Ala Tyr Glu Arg Pro Glu Glu Asp Glu Asn Glu Glu Ala Pro Val Ala 
305                 310                 315                 320 


Arg Asp Glu Ala Gly Ile Val Ser Gln Glu Glu Gln Gly Gly Gln Pro 
                325                 330                 335     


Gly Gln Pro Thr Gly Gln Glu Glu Leu Arg Ser Leu Val Leu Asp Trp 
            340                 345                 350         


Val His Gly Arg Ile Ser Asn Phe His Tyr Leu Met Gln Leu Asn Arg 
        355                 360                 365             


Leu Ala Gly Arg Arg Gln Gly Asp Pro Asn Tyr His Pro Val Leu Pro 
    370                 375                 380                 


Trp Val Val Asp Phe Thr Thr Pro His Gly Arg Phe Arg Asp Leu Arg 
385                 390                 395                 400 


Lys Ser Lys Phe Arg Leu Asn Lys Gly Asp Lys Gln Leu Asp Phe Thr 
                405                 410                 415     


Tyr Glu Met Thr Arg Gln Ala Phe Val Ala Gly Gly Ala Gly Gly Gly 
            420                 425                 430         


Glu Pro Pro His Val Pro His His Ile Ser Asp Val Leu Ser Asp Ile 
        435                 440                 445             


Thr Tyr Tyr Val Tyr Lys Ala Arg Arg Thr Pro Arg Ser Val Leu Cys 
    450                 455                 460                 


Gly His Val Arg Ala Gln Trp Glu Pro His Glu Tyr Pro Ala Ser Met 
465                 470                 475                 480 


Glu Arg Met Gln Asn Trp Thr Pro Asp Glu Cys Ile Pro Glu Phe Tyr 
                485                 490                 495     


Thr Asp Pro Ser Ile Phe Arg Ser Ile His Pro Asp Met Pro Asp Leu 
            500                 505                 510         


Asp Val Pro Ala Trp Cys Ser Ser Ser Gln Glu Phe Val Ala Ala His 
        515                 520                 525             


Arg Ala Leu Leu Glu Ser Arg Glu Val Ser Arg Asp Leu His His Trp 
    530                 535                 540                 


Ile Asp Leu Thr Phe Gly Tyr Lys Leu Gln Gly Lys Glu Ala Val Lys 
545                 550                 555                 560 


Glu Lys Asn Val Cys Leu His Leu Val Asp Ala His Thr His Leu Ala 
                565                 570                 575     


Ser Tyr Gly Val Val Gln Leu Phe Asp Gln Pro His Pro Gln Arg Leu 
            580                 585                 590         


Ala Gly Ala Pro Ala Leu Ala Pro Glu Pro Pro Leu Ile Pro Lys Leu 
        595                 600                 605             


Leu Val Gln Thr Ile Gln Glu Thr Thr Gly Arg Glu Asp Phe Thr Glu 
    610                 615                 620                 


Asn Pro Gly Gln Leu Pro Asn Gly Val Gly Arg Pro Val Leu Glu Ala 
625                 630                 635                 640 


Thr Pro Cys Glu Ala Ser Trp Thr Arg Asp Arg Pro Val Ala Gly Glu 
                645                 650                 655     


Asp Asp Leu Glu Gln Ala Thr Glu Ala Leu Asp Ser Ile Ser Leu Ala 
            660                 665                 670         


Gly Lys Ala Gly Asp Gln Leu Gly Ser Ser Ser Gln Ala Ser Pro Gly 
        675                 680                 685             


Leu Leu Ser Phe Ser Val Ala Ser Ala Ser Arg Pro Gly Arg Arg Asn 
    690                 695                 700                 


Lys Ala Ala Gly Ala Asp Pro Gly Glu Gly Glu Glu Gly Arg Ile Leu 
705                 710                 715                 720 


Leu Pro Glu Gly Phe Asn Pro Met Gln Ala Leu Glu Glu Leu Glu Lys 
                725                 730                 735     


Thr Gly Asn Phe Leu Ala Lys Gly Leu Gly Gly Leu Leu Glu Val Pro 
            740                 745                 750         


Glu Gln Pro Arg Val Gln Pro Ala Val Pro Leu Gln Cys Leu Leu His 
        755                 760                 765             


Arg Asp Met Gln Ala Leu Gly Val Leu Leu Ala Glu Met Val Phe Ala 
    770                 775                 780                 


Thr Arg Val Arg Thr Leu Gln Pro Asp Ala Pro Leu Trp Val Arg Phe 
785                 790                 795                 800 


Gln Ala Val Arg Gly Leu Cys Thr Arg His Pro Lys Glu Val Pro Val 
                805                 810                 815     


Ser Leu Gln Pro Val Leu Asp Thr Leu Leu Gln Met Ser Gly Pro Glu 
            820                 825                 830         


Val Pro Met Gly Ala Glu Arg Gly Lys Leu Asp Gln Leu Phe Glu Tyr 
        835                 840                 845             


Arg Pro Val Ser Gln Gly Leu Pro Pro Pro Cys Pro Ser Gln Leu Leu 
    850                 855                 860                 


Ser Pro Phe Ser Ser Val Val Pro Phe Pro Pro Tyr Phe Pro Ala Leu 
865                 870                 875                 880 


His Arg Phe Ile Leu Leu Tyr Gln Ala Arg Arg Val Glu Asp Glu Ala 
                885                 890                 895     


Gln Gly Arg Glu Leu Val Phe Ala Leu Trp Gln Gln Leu Gly Ala Val 
            900                 905                 910         


Leu Lys Asp Ile Thr Pro Glu Gly Leu Glu Ile Leu Leu Pro Phe Val 
        915                 920                 925             


Leu Ser Leu Met Ser Glu Glu His Thr Ala Val Tyr Thr Ala Trp Tyr 
    930                 935                 940                 


Leu Phe Glu Pro Val Ala Lys Ala Leu Gly Pro Lys Asn Ala Asn Lys 
945                 950                 955                 960 


Tyr Leu Leu Lys Pro Leu Ile Gly Ala Tyr Glu Ser Pro Cys Gln Leu 
                965                 970                 975     


His Gly Arg Phe Tyr Leu Tyr Thr Asp Cys Phe Val Ala Gln Leu Met 
            980                 985                 990         


Val Arg Leu Gly Leu Gln Ala Phe  Leu Thr His Leu Leu  Pro His Val 
        995                 1000                 1005             


Leu Gln  Val Leu Ala Gly Ala  Glu Ala Ser Gln Glu  Glu Ser Lys 
    1010                 1015                 1020             


Asp Leu  Ala Gly Ala Ala Glu  Glu Glu Glu Ser Gly  Leu Pro Gly 
    1025                 1030                 1035             


Ala Gly  Pro Gly Ser Cys Ala  Phe Gly Glu Glu Ile  Pro Met Asp 
    1040                 1045                 1050             


Gly Glu  Pro Pro Ala Ser Ser  Gly Leu Gly Leu Pro  Asp Tyr Thr 
    1055                 1060                 1065             


Ser Gly  Val Ser Phe His Asp  Gln Ala Asp Leu Pro  Glu Thr Glu 
    1070                 1075                 1080             


Asp Phe  Gln Ala Gly Leu Tyr  Val Thr Glu Ser Pro  Gln Pro Gln 
    1085                 1090                 1095             


Glu Ala  Glu Ala Val Ser Leu  Gly Arg Leu Ser Asp  Lys Ser Ser 
    1100                 1105                 1110             


Thr Ser  Glu Thr Ser Leu Gly  Glu Glu Arg Ala Pro  Asp Glu Gly 
    1115                 1120                 1125             


Gly Ala  Pro Val Asp Lys Ser  Ser Leu Arg Ser Gly  Asp Ser Ser 
    1130                 1135                 1140             


Gln Asp  Leu Lys Gln Ser Glu  Gly Ser Glu Glu Glu  Glu Glu Glu 
    1145                 1150                 1155             


Glu Asp  Ser Cys Val Val Leu  Glu Glu Glu Glu Gly  Glu Gln Glu 
    1160                 1165                 1170             


Glu Val  Thr Gly Ala Ser Glu  Leu Thr Leu Ser Asp  Thr Val Leu 
    1175                 1180                 1185             


Ser Met  Glu Thr Val Val Ala  Gly Gly Ser Gly Gly  Asp Gly Glu 
    1190                 1195                 1200             


Glu Glu  Glu Glu Ala Leu Pro  Glu Gln Ser Glu Gly  Lys Glu Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asp Thr Ala  Cys Lys Met Val Arg  Trp Leu Ser 
    1220                 1225                 1230             


Ala Lys  Leu Gly Pro Thr Val  Ala Ser Arg His Val  Ala Arg Asn 
    1235                 1240                 1245             


Leu Leu  Arg Leu Leu Thr Ser  Cys Tyr Val Gly Pro  Thr Arg Gln 
    1250                 1255                 1260             


Gln Phe  Thr Val Ser Ser Gly  Glu Ser Pro Pro Leu  Ser Ala Gly 
    1265                 1270                 1275             


Asn Ile  Tyr Gln Lys Arg Pro  Val Leu Gly Asp Ile  Val Ser Gly 
    1280                 1285                 1290             


Pro Val  Leu Ser Cys Leu Leu  His Ile Ala Arg Leu  Tyr Gly Glu 
    1295                 1300                 1305             


Pro Val  Leu Thr Tyr Gln Tyr  Leu Pro Tyr Ile Ser  Tyr Leu Val 
    1310                 1315                 1320             


Ala Pro  Gly Ser Ala Ser Gly  Pro Ser Arg Leu Asn  Ser Arg Lys 
    1325                 1330                 1335             


Glu Ala  Gly Leu Leu Ala Ala  Val Thr Leu Thr Gln  Lys Ile Ile 
    1340                 1345                 1350             


Val Tyr  Leu Ser Asp Thr Thr  Leu Met Asp Ile Leu  Pro Arg Ile 
    1355                 1360                 1365             


Ser His  Glu Val Leu Leu Pro  Val Leu Ser Phe Leu  Thr Ser Leu 
    1370                 1375                 1380             


Val Thr  Gly Phe Pro Ser Gly  Ala Gln Ala Arg Thr  Ile Leu Cys 
    1385                 1390                 1395             


Val Lys  Thr Ile Ser Leu Ile  Ala Leu Ile Cys Leu  Arg Ile Gly 
    1400                 1405                 1410             


Gln Glu  Met Val Gln Gln His  Leu Ser Glu Pro Val  Ala Thr Phe 
    1415                 1420                 1425             


Phe Gln  Val Phe Ser Gln Leu  His Glu Leu Arg Gln  Gln Asp Leu 
    1430                 1435                 1440             


Lys Leu  Asp Pro Ala Gly Arg  Gly Glu Gly Gln Leu  Pro Gln Val 
    1445                 1450                 1455             


Val Phe  Ser Asp Gly Gln Gln  Arg Pro Val Asp Pro  Ala Leu Leu 
    1460                 1465                 1470             


Asp Glu  Leu Gln Lys Val Phe  Thr Leu Glu Met Ala  Tyr Thr Ile 
    1475                 1480                 1485             


Tyr Val  Pro Phe Ser Cys Leu  Leu Gly Asp Ile Ile  Arg Lys Ile 
    1490                 1495                 1500             


Ile Pro  Asn His Glu Leu Val  Gly Glu Leu Ala Ala  Leu Tyr Leu 
    1505                 1510                 1515             


Glu Ser  Ile Ser Pro Ser Ser  Arg Asn Pro Ala Ser  Val Glu Pro 
    1520                 1525                 1530             


Thr Met  Pro Gly Thr Gly Pro  Glu Trp Asp Pro His  Gly Gly Gly 
    1535                 1540                 1545             


Cys Pro  Gln Asp Asp Gly His  Ser Gly Thr Phe Gly  Ser Val Leu 
    1550                 1555                 1560             


Val Gly  Asn Arg Ile Gln Ile  Pro Asn Asp Ser Arg  Pro Glu Asn 
    1565                 1570                 1575             


Pro Gly  Pro Leu Gly Pro Ile  Ser Gly Val Gly Gly  Gly Gly Leu 
    1580                 1585                 1590             


Gly Ser  Gly Ser Asp Asp Asn  Ala Leu Lys Gln Glu  Leu Pro Arg 
    1595                 1600                 1605             


Ser Val  His Gly Leu Ser Gly  Asn Trp Leu Ala Tyr  Trp Gln Tyr 
    1610                 1615                 1620             


Glu Ile  Gly Val Ser Gln Gln  Asp Ala His Phe His  Phe His Gln 
    1625                 1630                 1635             


Ile Arg  Leu Gln Ser Phe Pro  Gly His Ser Gly Ala  Val Lys Cys 
    1640                 1645                 1650             


Val Ala  Pro Leu Ser Ser Glu  Asp Phe Phe Leu Ser  Gly Ser Lys 
    1655                 1660                 1665             


Asp Arg  Thr Val Arg Leu Trp  Pro Leu Tyr Asn Tyr  Gly Asp Gly 
    1670                 1675                 1680             


Thr Ser  Glu Thr Ala Pro Arg  Leu Val Tyr Thr Gln  His Arg Lys 
    1685                 1690                 1695             


Ser Val  Phe Phe Val Gly Gln  Leu Glu Ala Pro Gln  His Val Val 
    1700                 1705                 1710             


Ser Cys  Asp Gly Ala Val His  Val Trp Asp Pro Phe  Thr Gly Lys 
    1715                 1720                 1725             


Thr Leu  Arg Thr Val Glu Pro  Leu Asp Ser Arg Val  Pro Leu Thr 
    1730                 1735                 1740             


Ala Val  Ala Val Met Pro Ala  Pro His Thr Ser Ile  Thr Met Ala 
    1745                 1750                 1755             


Ser Ser  Asp Ser Thr Leu Arg  Phe Val Asp Cys Arg  Lys Pro Gly 
    1760                 1765                 1770             


Leu Gln  His Glu Phe Arg Leu  Gly Gly Gly Leu Asn  Pro Gly Leu 
    1775                 1780                 1785             


Val Arg  Ala Leu Ala Ile Ser  Pro Ser Gly Arg Ser  Val Val Ala 
    1790                 1795                 1800             


Gly Phe  Ser Ser Gly Phe Met  Val Leu Leu Asp Thr  Arg Thr Gly 
    1805                 1810                 1815             


Leu Val  Leu Arg Gly Trp Pro  Ala His Glu Gly Asp  Ile Leu Gln 
    1820                 1825                 1830             


Ile Lys  Ala Val Glu Gly Ser  Val Leu Val Ser Ser  Ser Ser Asp 
    1835                 1840                 1845             


His Ser  Leu Thr Val Trp Lys  Glu Leu Glu Gln Lys  Pro Thr His 
    1850                 1855                 1860             


His Tyr  Lys Ser Ala Ser Asp  Pro Ile His Thr Phe  Asp Leu Tyr 
    1865                 1870                 1875             


Gly Ser  Glu Val Val Thr Gly  Thr Val Ser Asn Lys  Ile Gly Val 
    1880                 1885                 1890             


Cys Ser  Leu Leu Glu Pro Pro  Ser Gln Ala Thr Thr  Lys Leu Ser 
    1895                 1900                 1905             


Ser Glu  Asn Phe Arg Gly Thr  Leu Thr Ser Leu Ala  Leu Leu Pro 
    1910                 1915                 1920             


Thr Lys  Arg His Leu Leu Leu  Gly Ser Asp Asn Gly  Val Ile Arg 
    1925                 1930                 1935             


Leu Leu  Ala 
    1940     


<210>  534
<211>  3320
<212>  DNA
<213>  Homo sapiens

<400>  534
tggagaccct ttcagccccg ggaggaagcg gagcccagac cgagccagag cggagcagcg       60

ggagggaggg cggggaggcc gccgggcagg aagcggggtc ccgcccgggc ctctggagcc      120

acgtgcgctt gtttccgtgc tggggcgatc acgtgacccg cgtcagctga cccgtcacgg      180

tggagcccgg tgctcgcgcc cggcagcctc tgccccgccg cgcccggagc gcaggacccg      240

cggagggata cagcctgcaa gatggtccgc tggctgtctg ccaagctcgg ccccacagtg      300

gcctctcgcc acgtggcccg gaacctgctc cgcctgctga cgtcttgtta tgttggaccc      360

actcggcagc agttcacagt gagcagtggc gagagcccac cgctgagcgc cggcaacatc      420

taccagaaga ggccggtcct gggcgacatc gtgtcagggc ctgtgctcag ctgcctcctc      480

cacatcgccc gcctgtatgg ggagcctgtc ctcacctacc agtacctgcc ctacatcagc      540

tacctggtgg ccccagggag tgcctcaggc cccagccgac tgaacagccg taaggaggcg      600

gggctgctgg ccgcggtgac gctgactcag aagatcatcg tgtacctctc agacaccaca      660

ctcatggaca tcctgccccg gatcagccat gaggtcctgc tgcccgtgct cagcttcctc      720

acctccctcg tcacggggtt cccaagtggg gcccaggctc ggaccatcct gtgtgtgaaa      780

accatcagcc tcatcgccct catctgcctg cgcattggac aggagatggt ccagcagcac      840

ctgagcgagc ccgtggccac ctttttccag gtcttctctc agctgcatga gcttcggcaa      900

caggatctga agctggaccc tgcgggccgt ggtgagggcc agctgccaca ggtggtcttc      960

tctgatgggc agcagcggcc cgtggacccc gccctgctgg acgagctgca gaaggtgttc     1020

accctggaga tggcatacac aatctacgtg cccttctcct gcctgttggg tgacatcatc     1080

cggaaaatca tccccaacca cgagctggtt ggggagctgg cggcgctgta cttggagagc     1140

atcagcccca gcagtcgcaa ccctgccagc gtggagccca ccatgcccgg caccgggccc     1200

gagtgggacc cccatggtgg gggctgccct caggatgacg gccactcagg gacctttggg     1260

agcgtcctgg tggggaaccg cattcagatc cccaatgact ctcggcctga gaaccccgga     1320

ccactgggcc ccatctcggg ggtgggtggc gggggcctgg gcagcgggag cgacgacaac     1380

gccctgaagc aggagctgcc gcggagcgtg cacgggctga gcggaaactg gctggcgtac     1440

tggcagtacg agatcggcgt gagccagcag gatgcccact ttcacttcca ccagatccgc     1500

ctgcagagct tcccgggcca ctcgggggcc gtcaagtgcg tggcacccct aagcagcgag     1560

gacttcttcc tgagcggcag caaggatcgt accgtgcgcc tctggccgct gtacaactac     1620

ggcgacggga ccagcgagac ggccccacgc ctcgtctaca cccagcaccg caagagcgtc     1680

ttcttcgtgg gccagcttga ggccccgcag cacgtggtga gctgtgacgg ggctgtgcac     1740

gtctgggacc ccttcacagg gaagaccctt cgcacagtgg agccgctgga cagccgggtg     1800

cccctgactg cggtggctgt catgcccgcc ccccacacca gcatcaccat ggccagctct     1860

gactctaccc tgcgctttgt ggactgcagg aagcctggtc tgcagcacga gttccgactg     1920

ggcggtgggc tgaaccctgg gcttgtccgt gccctggcca tcagccccag tggccgtagt     1980

gtcgtggccg gcttctcctc aggcttcatg gtgctcctgg acacccgcac aggcctggtt     2040

ctgcgaggct ggccagccca cgagggggac attctgcaga tcaaggcggt ggagggcagc     2100

gtcctggtca gctcctcctc tgaccattcc ttgaccgtct ggaaggagct ggagcagaag     2160

cccacccatc actacaagtc agcatccgac cccatccaca cctttgacct gtacggcagc     2220

gaggtggtca ctggcaccgt gtccaacaag attggcgtct gctccctgct tgagccaccc     2280

tcgcaggcca ccacgaagct cagctctgag aacttccgcg gcacgctcac cagcctggcc     2340

ttgctgccca ctaaacgcca cctcctgctg ggctcagaca acggggttat ccgcctcctg     2400

gcatagactg aggcaggagc tggccgggca agggtgggaa gacatctgcg ggcgcgtgtc     2460

cactcaccct gttccctgag cagcagctcc ctccagggag gccctgggtc ccacgccctg     2520

ggtgcccaca tggcctgcca actagggcct gcaaatggag tgggggagtc ctggcccctg     2580

aatcaccaga gccaccaagc ctgccagagg ggtctcattc atggcttggg gacacagggc     2640

tcctagcaag caggaagtta agagcaggag gaagcgttgc taccttcact tctccccagc     2700

tctgccctct gggtccacat gaggacaggg aagctcggga aggggaaggg agactggccc     2760

tgcccagccg gtctctagcc cctcagcccc cgctgggcac tctctgtccc atccctctag     2820

gacagggaag ctggcctggt ccagggcact gatggtgctt ggattccagc ctaaggaagg     2880

ctggccgtgg tccaggagtt aagggcttgg gtctggggtt taagtggcca cccatccagg     2940

ccctggccag tgtgggaccg ggacgggaag gaagaaggag gctaggagca gggggaaaag     3000

gtgcacttgg ccagtggcgc ctgccaggag tgagtccatg cgttgtctgc ccacccctac     3060

cacagtgttt gtgccttcag ctgagggggc agcctctggg ccctgaaccc ctgctggggc     3120

tccacgaccc tgagagaagg ggtgagaaga atcatctctg cacctcgggt ctctgccaga     3180

ggaagactta agcatccctg cgacctcaca ttctagacag agatgaggtc caggggttgg     3240

cccctgctgc cttctcacaa tttgcaatag atgtaaatag gaccaataaa tcctttggaa     3300

gagccatggg gtgaactgag                                                 3320


<210>  535
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Val Arg Trp Leu Ser Ala Lys Leu Gly Pro Thr Val Ala Ser Arg 
1               5                   10                  15      


His Val Ala Arg Asn Leu Leu Arg Leu Leu Thr Ser Cys Tyr Val Gly 
            20                  25                  30          


Pro Thr Arg Gln Gln Phe Thr Val Ser Ser Gly Glu Ser Pro Pro Leu 
        35                  40                  45              


Ser Ala Gly Asn Ile Tyr Gln Lys Arg Pro Val Leu Gly Asp Ile Val 
    50                  55                  60                  


Ser Gly Pro Val Leu Ser Cys Leu Leu His Ile Ala Arg Leu Tyr Gly 
65                  70                  75                  80  


Glu Pro Val Leu Thr Tyr Gln Tyr Leu Pro Tyr Ile Ser Tyr Leu Val 
                85                  90                  95      


Ala Pro Gly Ser Ala Ser Gly Pro Ser Arg Leu Asn Ser Arg Lys Glu 
            100                 105                 110         


Ala Gly Leu Leu Ala Ala Val Thr Leu Thr Gln Lys Ile Ile Val Tyr 
        115                 120                 125             


Leu Ser Asp Thr Thr Leu Met Asp Ile Leu Pro Arg Ile Ser His Glu 
    130                 135                 140                 


Val Leu Leu Pro Val Leu Ser Phe Leu Thr Ser Leu Val Thr Gly Phe 
145                 150                 155                 160 


Pro Ser Gly Ala Gln Ala Arg Thr Ile Leu Cys Val Lys Thr Ile Ser 
                165                 170                 175     


Leu Ile Ala Leu Ile Cys Leu Arg Ile Gly Gln Glu Met Val Gln Gln 
            180                 185                 190         


His Leu Ser Glu Pro Val Ala Thr Phe Phe Gln Val Phe Ser Gln Leu 
        195                 200                 205             


His Glu Leu Arg Gln Gln Asp Leu Lys Leu Asp Pro Ala Gly Arg Gly 
    210                 215                 220                 


Glu Gly Gln Leu Pro Gln Val Val Phe Ser Asp Gly Gln Gln Arg Pro 
225                 230                 235                 240 


Val Asp Pro Ala Leu Leu Asp Glu Leu Gln Lys Val Phe Thr Leu Glu 
                245                 250                 255     


Met Ala Tyr Thr Ile Tyr Val Pro Phe Ser Cys Leu Leu Gly Asp Ile 
            260                 265                 270         


Ile Arg Lys Ile Ile Pro Asn His Glu Leu Val Gly Glu Leu Ala Ala 
        275                 280                 285             


Leu Tyr Leu Glu Ser Ile Ser Pro Ser Ser Arg Asn Pro Ala Ser Val 
    290                 295                 300                 


Glu Pro Thr Met Pro Gly Thr Gly Pro Glu Trp Asp Pro His Gly Gly 
305                 310                 315                 320 


Gly Cys Pro Gln Asp Asp Gly His Ser Gly Thr Phe Gly Ser Val Leu 
                325                 330                 335     


Val Gly Asn Arg Ile Gln Ile Pro Asn Asp Ser Arg Pro Glu Asn Pro 
            340                 345                 350         


Gly Pro Leu Gly Pro Ile Ser Gly Val Gly Gly Gly Gly Leu Gly Ser 
        355                 360                 365             


Gly Ser Asp Asp Asn Ala Leu Lys Gln Glu Leu Pro Arg Ser Val His 
    370                 375                 380                 


Gly Leu Ser Gly Asn Trp Leu Ala Tyr Trp Gln Tyr Glu Ile Gly Val 
385                 390                 395                 400 


Ser Gln Gln Asp Ala His Phe His Phe His Gln Ile Arg Leu Gln Ser 
                405                 410                 415     


Phe Pro Gly His Ser Gly Ala Val Lys Cys Val Ala Pro Leu Ser Ser 
            420                 425                 430         


Glu Asp Phe Phe Leu Ser Gly Ser Lys Asp Arg Thr Val Arg Leu Trp 
        435                 440                 445             


Pro Leu Tyr Asn Tyr Gly Asp Gly Thr Ser Glu Thr Ala Pro Arg Leu 
    450                 455                 460                 


Val Tyr Thr Gln His Arg Lys Ser Val Phe Phe Val Gly Gln Leu Glu 
465                 470                 475                 480 


Ala Pro Gln His Val Val Ser Cys Asp Gly Ala Val His Val Trp Asp 
                485                 490                 495     


Pro Phe Thr Gly Lys Thr Leu Arg Thr Val Glu Pro Leu Asp Ser Arg 
            500                 505                 510         


Val Pro Leu Thr Ala Val Ala Val Met Pro Ala Pro His Thr Ser Ile 
        515                 520                 525             


Thr Met Ala Ser Ser Asp Ser Thr Leu Arg Phe Val Asp Cys Arg Lys 
    530                 535                 540                 


Pro Gly Leu Gln His Glu Phe Arg Leu Gly Gly Gly Leu Asn Pro Gly 
545                 550                 555                 560 


Leu Val Arg Ala Leu Ala Ile Ser Pro Ser Gly Arg Ser Val Val Ala 
                565                 570                 575     


Gly Phe Ser Ser Gly Phe Met Val Leu Leu Asp Thr Arg Thr Gly Leu 
            580                 585                 590         


Val Leu Arg Gly Trp Pro Ala His Glu Gly Asp Ile Leu Gln Ile Lys 
        595                 600                 605             


Ala Val Glu Gly Ser Val Leu Val Ser Ser Ser Ser Asp His Ser Leu 
    610                 615                 620                 


Thr Val Trp Lys Glu Leu Glu Gln Lys Pro Thr His His Tyr Lys Ser 
625                 630                 635                 640 


Ala Ser Asp Pro Ile His Thr Phe Asp Leu Tyr Gly Ser Glu Val Val 
                645                 650                 655     


Thr Gly Thr Val Ser Asn Lys Ile Gly Val Cys Ser Leu Leu Glu Pro 
            660                 665                 670         


Pro Ser Gln Ala Thr Thr Lys Leu Ser Ser Glu Asn Phe Arg Gly Thr 
        675                 680                 685             


Leu Thr Ser Leu Ala Leu Leu Pro Thr Lys Arg His Leu Leu Leu Gly 
    690                 695                 700                 


Ser Asp Asn Gly Val Ile Arg Leu Leu Ala 
705                 710                 


<210>  536
<211>  3821
<212>  DNA
<213>  Homo sapiens

<400>  536
aaacgagagt cctaaagagc aggcgaaagc cacggcgtct gcgtttgcaa tgcatgctgg       60

tccgtgtagt tctcagcctg acaccgtcgt tcccagaacc cagcgcgctc tgtgctggcg      120

ggcgcagagg cctcccagga ggagagcaag gacctggcag gggctgctga ggaggaggag      180

agcgggctgc ccggggccgg gcctggctcc tgtgcttttg gggaggagat tcccatggat      240

ggggagcctc ctgcctcctc gggcctgggg ctcccagact acacgtctgg cgtcagcttc      300

cacgaccagg ctgacctccc tgagacagag gacttccaag ccgggctcta tgtgactgag      360

tctccccagc cccaggaggc tgaggctgtg agcctgggcc ggctgagtga caagagcagc      420

accagcgaga cctccctggg tgaggagcgg gctccagacg aggggggtgc ccccgtggac      480

aagagcagcc ttcgatcagg tgacagcagc caggacttga agcaaagcga gggctccgag      540

gaggaagagg aggaggagga cagctgcgtg gtgctagagg aggaggaggg ggagcaggag      600

gaggtcaccg gggcatctga gctcactctg tctgacacgg tgctgtccat ggagacggtt      660

gtggccggcg gcagtggggg agatggagaa gaagaggagg aggcactgcc tgagcagtca      720

gaaggcaaag aacagaagat cctccttgat acagcctgca agatggtccg ctggctgtct      780

gccaagctcg gccccacagt ggcctctcgc cacgtggccc ggaacctgct ccgcctgctg      840

acgtcttgtt atgttggacc cactcggcag cagttcacag tgagcagtgg cgagagccca      900

ccgctgagcg ccggcaacat ctaccagaag aggccggtcc tgggcgacat cgtgtcaggg      960

cctgtgctca gctgcctcct ccacatcgcc cgcctgtatg gggagcctgt cctcacctac     1020

cagtacctgc cctacatcag ctacctggtg gccccaggga gtgcctcagg ccccagccga     1080

ctgaacagcc gtaaggaggc ggggctgctg gccgcggtga cgctgactca gaagatcatc     1140

gtgtacctct cagacaccac actcatggac atcctgcccc ggatcagcca tgaggtcctg     1200

ctgcccgtgc tcagcttcct cacctccctc gtcacggggt tcccaagtgg ggcccaggct     1260

cggaccatcc tgtgtgtgaa aaccatcagc ctcatcgccc tcatctgcct gcgcattgga     1320

caggagatgg tccagcagca cctgagcgag cccgtggcca cctttttcca ggtcttctct     1380

cagctgcatg agcttcggca acaggatctg aagctggacc ctgcgggccg tggtgagggc     1440

cagctgccac aggtggtctt ctctgatggg cagcagcggc ccgtggaccc cgccctgctg     1500

gacgagctgc agaaggtgtt caccctggag atggcataca caatctacgt gcccttctcc     1560

tgcctgttgg gtgacatcat ccggaaaatc atccccaacc acgagctggt tggggagctg     1620

gcggcgctgt acttggagag catcagcccc agcagtcgca accctgccag cgtggagccc     1680

accatgcccg gcaccgggcc cgagtgggac ccccatggtg ggggctgccc tcaggatgac     1740

ggccactcag ggacctttgg gagcgtcctg gtggggaacc gcattcagat ccccaatgac     1800

tctcggcctg agaaccccgg accactgggc cccatctcgg gggtgggtgg cgggggcctg     1860

ggcagcggga gcgacgacaa cgccctgaag caggagctgc cgcggagcgt gcacgggctg     1920

agcggaaact ggctggcgta ctggcagtac gagatcggcg tgagccagca ggatgcccac     1980

tttcacttcc accagatccg cctgcagagc ttcccgggcc actcgggggc cgtcaagtgc     2040

gtggcacccc taagcagcga ggacttcttc ctgagcggca gcaaggatcg taccgtgcgc     2100

ctctggccgc tgtacaacta cggcgacggg accagcgaga cggccccacg cctcgtctac     2160

acccagcacc gcaagagcgt cttcttcgtg ggccagcttg aggccccgca gcacgtggtg     2220

agctgtgacg gggctgtgca cgtctgggac cccttcacag ggaagaccct tcgcacagtg     2280

gagccgctgg acagccgggt gcccctgact gcggtggctg tcatgcccgc cccccacacc     2340

agcatcacca tggccagctc tgactctacc ctgcgctttg tggactgcag gaagcctggt     2400

ctgcagcacg agttccgact gggcggtggg ctgaaccctg ggcttgtccg tgccctggcc     2460

atcagcccca gtggccgtag tgtcgtggcc ggcttctcct caggcttcat ggtgctcctg     2520

gacacccgca caggcctggt tctgcgaggc tggccagccc acgaggggga cattctgcag     2580

atcaaggcgg tggagggcag cgtcctggtc agctcctcct ctgaccattc cttgaccgtc     2640

tggaaggagc tggagcagaa gcccacccat cactacaagt cagcatccga ccccatccac     2700

acctttgacc tgtacggcag cgaggtggtc actggcaccg tgtccaacaa gattggcgtc     2760

tgctccctgc ttgagccacc ctcgcaggcc accacgaagc tcagctctga gaacttccgc     2820

ggcacgctca ccagcctggc cttgctgccc actaaacgcc acctcctgct gggctcagac     2880

aacggggtta tccgcctcct ggcatagact gaggcaggag ctggccgggc aagggtggga     2940

agacatctgc gggcgcgtgt ccactcaccc tgttccctga gcagcagctc cctccaggga     3000

ggccctgggt cccacgccct gggtgcccac atggcctgcc aactagggcc tgcaaatgga     3060

gtgggggagt cctggcccct gaatcaccag agccaccaag cctgccagag gggtctcatt     3120

catggcttgg ggacacaggg ctcctagcaa gcaggaagtt aagagcagga ggaagcgttg     3180

ctaccttcac ttctccccag ctctgccctc tgggtccaca tgaggacagg gaagctcggg     3240

aaggggaagg gagactggcc ctgcccagcc ggtctctagc ccctcagccc ccgctgggca     3300

ctctctgtcc catccctcta ggacagggaa gctggcctgg tccagggcac tgatggtgct     3360

tggattccag cctaaggaag gctggccgtg gtccaggagt taagggcttg ggtctggggt     3420

ttaagtggcc acccatccag gccctggcca gtgtgggacc gggacgggaa ggaagaagga     3480

ggctaggagc agggggaaaa ggtgcacttg gccagtggcg cctgccagga gtgagtccat     3540

gcgttgtctg cccaccccta ccacagtgtt tgtgccttca gctgaggggg cagcctctgg     3600

gccctgaacc cctgctgggg ctccacgacc ctgagagaag gggtgagaag aatcatctct     3660

gcacctcggg tctctgccag aggaagactt aagcatccct gcgacctcac attctagaca     3720

gagatgaggt ccaggggttg gcccctgctg ccttctcaca atttgcaata gatgtaaata     3780

ggaccaataa atcctttgga agagccatgg ggtgaactga g                         3821


<210>  537
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Asp Gly Glu Pro Pro Ala Ser Ser Gly Leu Gly Leu Pro Asp Tyr 
1               5                   10                  15      


Thr Ser Gly Val Ser Phe His Asp Gln Ala Asp Leu Pro Glu Thr Glu 
            20                  25                  30          


Asp Phe Gln Ala Gly Leu Tyr Val Thr Glu Ser Pro Gln Pro Gln Glu 
        35                  40                  45              


Ala Glu Ala Val Ser Leu Gly Arg Leu Ser Asp Lys Ser Ser Thr Ser 
    50                  55                  60                  


Glu Thr Ser Leu Gly Glu Glu Arg Ala Pro Asp Glu Gly Gly Ala Pro 
65                  70                  75                  80  


Val Asp Lys Ser Ser Leu Arg Ser Gly Asp Ser Ser Gln Asp Leu Lys 
                85                  90                  95      


Gln Ser Glu Gly Ser Glu Glu Glu Glu Glu Glu Glu Asp Ser Cys Val 
            100                 105                 110         


Val Leu Glu Glu Glu Glu Gly Glu Gln Glu Glu Val Thr Gly Ala Ser 
        115                 120                 125             


Glu Leu Thr Leu Ser Asp Thr Val Leu Ser Met Glu Thr Val Val Ala 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asp Gly Glu Glu Glu Glu Glu Ala Leu Pro Glu 
145                 150                 155                 160 


Gln Ser Glu Gly Lys Glu Gln Lys Ile Leu Leu Asp Thr Ala Cys Lys 
                165                 170                 175     


Met Val Arg Trp Leu Ser Ala Lys Leu Gly Pro Thr Val Ala Ser Arg 
            180                 185                 190         


His Val Ala Arg Asn Leu Leu Arg Leu Leu Thr Ser Cys Tyr Val Gly 
        195                 200                 205             


Pro Thr Arg Gln Gln Phe Thr Val Ser Ser Gly Glu Ser Pro Pro Leu 
    210                 215                 220                 


Ser Ala Gly Asn Ile Tyr Gln Lys Arg Pro Val Leu Gly Asp Ile Val 
225                 230                 235                 240 


Ser Gly Pro Val Leu Ser Cys Leu Leu His Ile Ala Arg Leu Tyr Gly 
                245                 250                 255     


Glu Pro Val Leu Thr Tyr Gln Tyr Leu Pro Tyr Ile Ser Tyr Leu Val 
            260                 265                 270         


Ala Pro Gly Ser Ala Ser Gly Pro Ser Arg Leu Asn Ser Arg Lys Glu 
        275                 280                 285             


Ala Gly Leu Leu Ala Ala Val Thr Leu Thr Gln Lys Ile Ile Val Tyr 
    290                 295                 300                 


Leu Ser Asp Thr Thr Leu Met Asp Ile Leu Pro Arg Ile Ser His Glu 
305                 310                 315                 320 


Val Leu Leu Pro Val Leu Ser Phe Leu Thr Ser Leu Val Thr Gly Phe 
                325                 330                 335     


Pro Ser Gly Ala Gln Ala Arg Thr Ile Leu Cys Val Lys Thr Ile Ser 
            340                 345                 350         


Leu Ile Ala Leu Ile Cys Leu Arg Ile Gly Gln Glu Met Val Gln Gln 
        355                 360                 365             


His Leu Ser Glu Pro Val Ala Thr Phe Phe Gln Val Phe Ser Gln Leu 
    370                 375                 380                 


His Glu Leu Arg Gln Gln Asp Leu Lys Leu Asp Pro Ala Gly Arg Gly 
385                 390                 395                 400 


Glu Gly Gln Leu Pro Gln Val Val Phe Ser Asp Gly Gln Gln Arg Pro 
                405                 410                 415     


Val Asp Pro Ala Leu Leu Asp Glu Leu Gln Lys Val Phe Thr Leu Glu 
            420                 425                 430         


Met Ala Tyr Thr Ile Tyr Val Pro Phe Ser Cys Leu Leu Gly Asp Ile 
        435                 440                 445             


Ile Arg Lys Ile Ile Pro Asn His Glu Leu Val Gly Glu Leu Ala Ala 
    450                 455                 460                 


Leu Tyr Leu Glu Ser Ile Ser Pro Ser Ser Arg Asn Pro Ala Ser Val 
465                 470                 475                 480 


Glu Pro Thr Met Pro Gly Thr Gly Pro Glu Trp Asp Pro His Gly Gly 
                485                 490                 495     


Gly Cys Pro Gln Asp Asp Gly His Ser Gly Thr Phe Gly Ser Val Leu 
            500                 505                 510         


Val Gly Asn Arg Ile Gln Ile Pro Asn Asp Ser Arg Pro Glu Asn Pro 
        515                 520                 525             


Gly Pro Leu Gly Pro Ile Ser Gly Val Gly Gly Gly Gly Leu Gly Ser 
    530                 535                 540                 


Gly Ser Asp Asp Asn Ala Leu Lys Gln Glu Leu Pro Arg Ser Val His 
545                 550                 555                 560 


Gly Leu Ser Gly Asn Trp Leu Ala Tyr Trp Gln Tyr Glu Ile Gly Val 
                565                 570                 575     


Ser Gln Gln Asp Ala His Phe His Phe His Gln Ile Arg Leu Gln Ser 
            580                 585                 590         


Phe Pro Gly His Ser Gly Ala Val Lys Cys Val Ala Pro Leu Ser Ser 
        595                 600                 605             


Glu Asp Phe Phe Leu Ser Gly Ser Lys Asp Arg Thr Val Arg Leu Trp 
    610                 615                 620                 


Pro Leu Tyr Asn Tyr Gly Asp Gly Thr Ser Glu Thr Ala Pro Arg Leu 
625                 630                 635                 640 


Val Tyr Thr Gln His Arg Lys Ser Val Phe Phe Val Gly Gln Leu Glu 
                645                 650                 655     


Ala Pro Gln His Val Val Ser Cys Asp Gly Ala Val His Val Trp Asp 
            660                 665                 670         


Pro Phe Thr Gly Lys Thr Leu Arg Thr Val Glu Pro Leu Asp Ser Arg 
        675                 680                 685             


Val Pro Leu Thr Ala Val Ala Val Met Pro Ala Pro His Thr Ser Ile 
    690                 695                 700                 


Thr Met Ala Ser Ser Asp Ser Thr Leu Arg Phe Val Asp Cys Arg Lys 
705                 710                 715                 720 


Pro Gly Leu Gln His Glu Phe Arg Leu Gly Gly Gly Leu Asn Pro Gly 
                725                 730                 735     


Leu Val Arg Ala Leu Ala Ile Ser Pro Ser Gly Arg Ser Val Val Ala 
            740                 745                 750         


Gly Phe Ser Ser Gly Phe Met Val Leu Leu Asp Thr Arg Thr Gly Leu 
        755                 760                 765             


Val Leu Arg Gly Trp Pro Ala His Glu Gly Asp Ile Leu Gln Ile Lys 
    770                 775                 780                 


Ala Val Glu Gly Ser Val Leu Val Ser Ser Ser Ser Asp His Ser Leu 
785                 790                 795                 800 


Thr Val Trp Lys Glu Leu Glu Gln Lys Pro Thr His His Tyr Lys Ser 
                805                 810                 815     


Ala Ser Asp Pro Ile His Thr Phe Asp Leu Tyr Gly Ser Glu Val Val 
            820                 825                 830         


Thr Gly Thr Val Ser Asn Lys Ile Gly Val Cys Ser Leu Leu Glu Pro 
        835                 840                 845             


Pro Ser Gln Ala Thr Thr Lys Leu Ser Ser Glu Asn Phe Arg Gly Thr 
    850                 855                 860                 


Leu Thr Ser Leu Ala Leu Leu Pro Thr Lys Arg His Leu Leu Leu Gly 
865                 870                 875                 880 


Ser Asp Asn Gly Val Ile Arg Leu Leu Ala 
                885                 890 


<210>  538
<211>  4292
<212>  DNA
<213>  Homo sapiens

<400>  538
ttctgcctgt cgccccaaaa tggcggacac aatgagccgg cgacgcgccg gttgtccgtg       60

aggtggctgt gaggacgaac ggtcggcgag gctccacagt ccaggcagaa gaccctcgac      120

caagcaggaa gaagaggagg aggcggccca actgttggcc gacttcccgc tagccgccgg      180

cgcggcgccc gccccgcctg ggttggcccc tcggcagccc gcccgctcgc cgccgggccc      240

cgccccggcc ctgcgccgcc gctgccttcc ccagccgccg ccatgaagct gaccgacagc      300

gtgttgcgga gcttccgcgt cgctaaggtg ttccgcgaaa actcggacaa gattaactgc      360

ttcgatttca gccccaacgg cgagacggtc atctcgagta gcgacgacga ctccatcgtg      420

ctctatgact gccaggaggg caaaccaaag agaaccctgt acagtaagaa atatggtgtg      480

gacctcatca gatacactca tgcagcaaac acagttgttt acagctctaa caaaatagac      540

gatactattc gttacttgtc cttgcatgac aacaaataca tcagatactt tcctggacat      600

agcaaaaggg tggtggcctt gtccatgtca cctgtggatg acactttcat ttctgggtct      660

cttgataaga ccattcgact ctgggatctc cggtctccta actgccaggg cctcatgcat      720

ctgcagggga agccagtttg ttcttttgat ccagaagggt taattttcgc tgcaggtgtc      780

aactctgaaa tggtcaagct ttatgacctt cgttcttttg ataaggggcc atttgctacc      840

tttaagatgc agtatgatcg aacttgtgag tggacaggac ttaaattcag caatgatggc      900

aagctcatcc tcatttccac caacggcagc ttcattcgtc tgattgatgc attcaaagga      960

gtggtgatgc acacatttgg gggttatgcc aacagcaaag ctgtcacact ggaggcttca     1020

tttactccag actctcagtt tattatgatt ggttcagagg atggcaagat ccatgtctgg     1080

aatggagaga gcggtataaa agtagctgtg ttggatggta aacacacagg cccgattacc     1140

tgtttgcaat tcaaccccaa gttcatgact tttgccagtg cgtgttccaa catggccttt     1200

tggttgccca ccattgatga ctgaccctgt tgctgcttgg ctatttctgt atagtgaggg     1260

cggccagcag gaagaaactc agagggaact gagataatag tgggattgga tcatttgact     1320

gggctggaga acatcctttt acatggcctt cccatggatg tgctgtacat ctgctcaaaa     1380

gaaaataatt actttgatga gcgtcttcaa aaggactctt ggtgcaacag actcaattgg     1440

aactcagctt ttctaactgt cactgcacca agctctgctg gaggagtgac cagactcacg     1500

atttggtata gtggggctct caagcatctt caatttgaat gtacatgctg ctgaggagcc     1560

ggtgaagtca tcagttccgc acatcccttc taccctccaa ctgcatggga agccaaagtc     1620

ctggttttga aatgcttggg cagctcagcc gcttgccctc accctgcatg tcttgttact     1680

gggtctccct gtgtacttgt ggcattatcc acaaccatca tgtttcttag gtgccaaaca     1740

tttacagaaa cattttcata tatcttgggg tcagagaaag ggacagatac agaaggacct     1800

tgcttgcagg aagccatgca gttagtttct gcagttagtc gtgtgaggct aggtggttgg     1860

gcaggcctcg ggctgtaggt gttgggtggg aaaaagaccc aagggcctga aagggaggga     1920

aaggggaggg tagcgggagg gtagcaggtg agttcctagg gctggaaggt ttagcagcag     1980

cctggtgcag tgccctgtca tcaagacaaa cccacggtcc tcctgggtgc ctaccaagct     2040

tggtttgtac aaaagcaagg tgggagtcta tttttgtaca tgagatacat cacacttacc     2100

tgtgggccag tattgtgaag tgagtctgag ttgtttacac tgatgccttc cctgcccacc     2160

acaaattgtg tacatagtct tcagatgata ccaccccttt ccccagctcc caaccaagag     2220

ctggttctag gcctgtgtta tatgtcatat ttagcgtttt tatatatgac ctttgatttc     2280

tgttgtttgt attttagcac agtgtatgca ccttcattta aatacatctg tgtgcataca     2340

gatacgcata tatgtgtgtg cgtatgcata tatctctcat ctgtagtttc caagagttca     2400

gctgaagcag atggagtcct gcagcccagg agacaccctg catccctgct aatagtgttt     2460

gccacaagta ttagtgagtc ttccttatta atattttcat ttcagaagac tgaagcaaag     2520

ctgatagtgt ttgctgtttc tttggcagct aagtgagggt cttgggatga cttgctgtgt     2580

tcctcaagct gcactttggg gccatctctg cagtattagc cccctttttg cttggtggta     2640

ctctgtctgt gcctgtgtgt gtgtgtgata gtcactcttg catggcttcc atgtctggtt     2700

tgtggcattt ggggataagg tgctgaagcc agagcatttg cagtttgttt gaggcctcgt     2760

tgccaatgat agatcactcc tgttgacctg gtatgtctgc ttgcttgctg cttttccttg     2820

ctttctcttg gaagaggaaa ggactctggt caggcccagg ctgagtgaga tgagctgcag     2880

ctggctcatg gccttcttag agcagagaga ggagtatgtc attttactaa gttcctaaac     2940

aaacatttat gcaggcaaca ctccttgcag atccagaaac tgaggcacaa tagggttatg     3000

acttgctcaa gaatatgtag ctgctagggg gtaaatcaag gcatcacaat ttctgttcag     3060

cgggcaggaa taggctgtga attgctagca cttttttttt ttaagcaatt actttttgac     3120

ttgttcctct gaaagtgcaa gaggcgtaca cctttcccaa atgtagacta gaatctgcag     3180

gatgccaccc actgtatagt tctgctttcc cagagaggaa gaacttttag aaaccaaatg     3240

atcttaattg ttattgccca cccctggctt ttccgggtag aaaattcaca gtaggaatga     3300

ttgttaagag agagtgcttg gaaccatggg ttaacaggaa aggctaccta acttcacata     3360

tctgcaacca gagcagccac caagcattac ttagcagcag gaaaatgatt gtatttgagt     3420

tcctgtgtgt ccaaaactga gcaccatgtt ctttgaaaac atgccacctc aaggctgggc     3480

gcggtggctc acacctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcaccgga     3540

ggtcgggagt ttgagaccag cctgaccaac atggagaaac cccatctcta ctaaaaatac     3600

aaaattagcc gggcgtggtg gcatgcgcct ataatctcag ctacttggga ggctgaggca     3660

ggagaattgc ttgaacccag gaggcggagg ttgcggtgag ttgagatcgt gccattgcac     3720

tccggcctgg gcaacaacag caaaactccg tctcaaaaaa aaaaaaaaaa aaatgccacc     3780

tcacagtctc tatcgttggg ccctgtggtt gcaaagctgc ctcctgaatt aagaaggaaa     3840

gggaaaagat atagctggaa gcgagtggaa gagatgctga gggctggggc tgcacagacg     3900

tgctcagcag ggctacaggt gctcaagccc tattggggat gggtggggag tggggcagcg     3960

gcgtttgcca ccttaagaat tggggccaaa gccactgatg tttatttgac agtgacactg     4020

cactgggtac ttaaagaaat tatttcccgt tgtaattata attactgctt attaaggaaa     4080

atatgggaat tttagaaaga atcaagtttg ccacccaaat gctaccactg ttaatctttt     4140

ggtgttaaat gttcccccta gacatttctg tgcatagatt tttggtgtgt ttacatagtc     4200

gttattctgt atatacaatt ttatgtccct tttgtactta acgtataaac attttttcca     4260

tgttacagtc ttaaacagaa ttttatggct gc                                   4292


<210>  539
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Lys Leu Thr Asp Ser Val Leu Arg Ser Phe Arg Val Ala Lys Val 
1               5                   10                  15      


Phe Arg Glu Asn Ser Asp Lys Ile Asn Cys Phe Asp Phe Ser Pro Asn 
            20                  25                  30          


Gly Glu Thr Val Ile Ser Ser Ser Asp Asp Asp Ser Ile Val Leu Tyr 
        35                  40                  45              


Asp Cys Gln Glu Gly Lys Pro Lys Arg Thr Leu Tyr Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Val Asp Leu Ile Arg Tyr Thr His Ala Ala Asn Thr Val Val Tyr 
65                  70                  75                  80  


Ser Ser Asn Lys Ile Asp Asp Thr Ile Arg Tyr Leu Ser Leu His Asp 
                85                  90                  95      


Asn Lys Tyr Ile Arg Tyr Phe Pro Gly His Ser Lys Arg Val Val Ala 
            100                 105                 110         


Leu Ser Met Ser Pro Val Asp Asp Thr Phe Ile Ser Gly Ser Leu Asp 
        115                 120                 125             


Lys Thr Ile Arg Leu Trp Asp Leu Arg Ser Pro Asn Cys Gln Gly Leu 
    130                 135                 140                 


Met His Leu Gln Gly Lys Pro Val Cys Ser Phe Asp Pro Glu Gly Leu 
145                 150                 155                 160 


Ile Phe Ala Ala Gly Val Asn Ser Glu Met Val Lys Leu Tyr Asp Leu 
                165                 170                 175     


Arg Ser Phe Asp Lys Gly Pro Phe Ala Thr Phe Lys Met Gln Tyr Asp 
            180                 185                 190         


Arg Thr Cys Glu Trp Thr Gly Leu Lys Phe Ser Asn Asp Gly Lys Leu 
        195                 200                 205             


Ile Leu Ile Ser Thr Asn Gly Ser Phe Ile Arg Leu Ile Asp Ala Phe 
    210                 215                 220                 


Lys Gly Val Val Met His Thr Phe Gly Gly Tyr Ala Asn Ser Lys Ala 
225                 230                 235                 240 


Val Thr Leu Glu Ala Ser Phe Thr Pro Asp Ser Gln Phe Ile Met Ile 
                245                 250                 255     


Gly Ser Glu Asp Gly Lys Ile His Val Trp Asn Gly Glu Ser Gly Ile 
            260                 265                 270         


Lys Val Ala Val Leu Asp Gly Lys His Thr Gly Pro Ile Thr Cys Leu 
        275                 280                 285             


Gln Phe Asn Pro Lys Phe Met Thr Phe Ala Ser Ala Cys Ser Asn Met 
    290                 295                 300                 


Ala Phe Trp Leu Pro Thr Ile Asp Asp 
305                 310             


<210>  540
<211>  5525
<212>  DNA
<213>  Homo sapiens

<400>  540
ggggacggtg ggagcagatc catttccggg ttggcaaaag gggcggtggc ggcggcggcg       60

gcggcggcgg cggcggcgac ggcgagaaag agcttgccgg ggggcgagca ggacaggacg      120

aagccggagt gtaggcggca gaggattcgc tcccagagca gctgcggcca ggtatatgaa      180

tgacctaaag gtacaaataa agacggagag agaacagtgc caactgggag cagggcaaga      240

atgccaattc ctcctccccc gccaccccca cctggtcctc ctccacctcc cacatttcat      300

caggcaaaca cagagcagcc caagctgagt agagatgagc agcggggtcg aggcgccctc      360

ttacaggaca tttgcaaagg gaccaagctg aagaaggtga ccaacattaa tgatcggagt      420

gctcccatcc tcgagaagcc gaaaggaagc agtggtggct atggctctgg aggagctgcc      480

ctgcagccca agggaggtct cttccaagga ggagtgctga agcttcgacc tgtgggagcc      540

aaggatggtt cagagaacct agctggtaag ccagccctgc aaatccccag ttctcgagct      600

gctgccccaa ggcctccagt atctgccgcc agcgggcgtc ctcaggatga tacagacagc      660

agccgggcct cactcccaga actgccccgg atgcagagac cctctttacc ggacctctct      720

cggcctaata ccaccagcag tacgggcatg aagcacagct cctctgcccc tcccccacca      780

cccccagggc ggcgtgccaa cgcacccccc acacctctgc ctatgcacag cagcaaagcc      840

cccgcctaca acagagagaa acccttgcca ccgacgcctg gacaaaggct tcaccctggt      900

cgagagggac ctcctgctcc acccccagtc aaaccacctc cttcccctgt gaatatcaga      960

acaggaccaa gtggccagtc tctggctcct cctcctccgc cttaccgcca gcctcctggg     1020

gtccccaatg gaccctctag ccccactaat gagtcagccc ctgagctgcc acagagacac     1080

aattctttgc ataggaagac accagggcct gtcagaggcc tagcacctcc tccacccacc     1140

tcggcctccc catctttact gagtaatagg ccacctcccc cagcccgaga ccctcccagt     1200

cggggagcag ctcctccacc cccaccacct gtgatccgaa atggtgccag ggatgctccc     1260

cctcccccac caccataccg aatgcatggg tcagaacccc cgagccgagg aaagccccca     1320

cctccaccct caaggacgcc agctgggcca ccccctcctc ctccaccgcc cctgaggaat     1380

ggccacagag attctatcac cactgtccgg tctttcttgg atgattttga gtcaaagtat     1440

tccttccatc cagtagaaga ctttcctgct ccagaagaat ataaacactt tcagaggata     1500

tatcccagca aaacaaaccg agctgcccgt ggagccccac ctctgccacc cattctcagg     1560

tgaagcctgg cttggtcccg ttcctcagga aaaggatgga ccttctcttc ttctcagatg     1620

gtcccttcca ttcccctgaa acctgcatga gagctcctaa catgtttctc caatgcaatc     1680

aagccctaga ctccaaatgt cctcccagct cacctccatc tatgcatctc atctctggat     1740

ttggtgatca gactctatat tgacagtagg atctcaaacc ctgcatccat ccttcctcca     1800

gcaagccctg ctagccacat gaggaacaag tttccgtgtc ttctgccttc ctcttgggga     1860

aaggtgcctt gttgtgatga attaactcac tgttagggca gggtggagaa tggtactcct     1920

tccttctcct gtccactgtg ggggaagctt ggcaggtata ttatatttca tcatttagga     1980

ggctggcatg accaggactt atgggtggga ggggagcatt tttagtgaag caagaaagga     2040

gtttgccaag aagtgatctg ttttaaaggt catatttgga gaaagggcaa ggaattgggt     2100

ctgctttatt tttgggggta ttttgttttt gttctcacct gctgcccccc caccccacca     2160

ccccagggat aaattggata taaacactaa atactaatca gttgaactta acatttaata     2220

aaaagaaagg gtgaaataaa ctgaagacca ttttagaact agtcagttct ctgcagcaaa     2280

gggaacagga gccatttgaa ccctctggga cccctcaccc cactgcttca gggtgctagg     2340

ctgagggatg tttttcctcc cccttaccgc ccatgccctt gaaagaaaag tcactttttg     2400

tggagggcat cattcattcc tgattcacaa accccaaaaa cctctggtgg gagataggaa     2460

gatagggcgt gggcctgggc cttaacctca atcttgtgtc tgcctcagtc ttttctgact     2520

ggccctgaag ttgtcagtgg ctctttctgt ccttcagccc ctggaaggtg ctccaggata     2580

acaaagaagg gcaggttgaa gcccctcatg gaaggagctg gctttgtggg gctgcaaagg     2640

acttttaagt cctgcctgta ctgaagttca cagcccacct gactgagcag actcttcctg     2700

ttcctttctc taccaccctt gccttcccag gactgcacgg tttaacacag cagagtacag     2760

aagggtgaag aagtgagcag aggcttatga agatattcag atactcttct atgccaggaa     2820

gcacaaagac tttgttgaga tttgcctcag ttcagtagat cttccttggc agccagccat     2880

aggttgtttc tttgtcttcc gggtcctaaa gagcacagag aaaatggagg tccccagtct     2940

aggtaggaag ctgattggat gaggacttct ttttttccga cagcaggatg gggctcttgg     3000

gctccacaca ccagatgctt tggttttcta caactgttgc tatgtgtaga gggtgctcag     3060

agcgtggcat gagagcaagg agaccatggc tactctttga aatggatggg gaaaattagc     3120

ttaaaaattt aatcacgaga ttgcgccact gcactccagc ctgggcgaca gagccagact     3180

ccgtctcaaa aaaaaaaaaa aaaaaaaaat ttaatcacac acatcacagg cttaaactgt     3240

cttagagacc tttccagttg attggatcac aggctaggga tctgtgcatg gtgccaggtg     3300

aaacccaagt ctccccagtg ctaggtgagg gagggctcaa cgggggtaat gtgtatgggg     3360

tctgctgtcc tttgccatcc cctggaccat attaactctg ggacagacca tgattaggtc     3420

tgtcaccaaa cttttcctaa tcatttttta tgtatcattc ttctttctaa tctgttagca     3480

gttatctccc agaagtatcc ctagcatcct gaagcaaaca gaactgccgg gcgctgtggc     3540

ttatgcctgt aatctcagca atttgggagg ccgaggcggg cggatcacct gaggtcagaa     3600

gttcgagacc agcctgtcca acatggtgaa accccgtctc cactaaaaac acaaaaatta     3660

tctgggcgtg gtggcatgtg cctgtagtcc cagctactgg ggaggctgag gcaggagaat     3720

cgcttgaatc caggaggtgg aggttgcagt gagtggagat ggcgccactg cgctccagcc     3780

cgggtgacag agtgaaactc catctcagaa aacaaacaaa ccaaacaact gagagagggc     3840

atgctagtgg agggaaaagg agagagtaca agagttgata ctgcatcaga gttccagggc     3900

agatactgac aagtgactga actttgactg tgaagtcttc ccatttattt ttgaaatggg     3960

agtcgatgcc ttttgtacgt tatcaaagtg tttttttttt tttcctcctt tactcagaca     4020

tagagcatca aaatatcacg agtaaagcca aaccccagct tttcactggg gctgatatct     4080

tcctccccat ggcccactgc cccctcatat tccccagcac ttggactgtg tcacatgggt     4140

attgattgta tacttgttgt cttggcctca tgcaaaaagg cctgggtcta gatctagtca     4200

gatgagtttt ttttagagca tgttgatgat acaacacctg tttaaatgtc tgccttatat     4260

gttatttggt cccactgtta ataatagatt tattactatg tatatttact attgaagatg     4320

ggaatgtgat ctgcatagtt atcagtctat tttgtatgtt gtaaaaagct tctaatttag     4380

gtttaaggtg ggctggctac aagagcacta aaactcctca ccttttaaac tgctcttttt     4440

atctgcttgt gggaatgtcg tctctttcgt ggaagattgg gtggtctcat gttgaggctg     4500

ttgcccagtc ccattaactc ccttgtcccc ccacagaagg aagagacatt gcccagctaa     4560

gcatcaggaa gctgtgttaa aagcccttct atgggtttgg ttttgtgatg tttttcccta     4620

atgggaaaaa cgttatagtt gtttcttact gccctgtctg ggaagcaggg caaacctcca     4680

ggtttttaaa tgagctagat gcccctcttc ctcttctctg gtcactgaac ctggaccaaa     4740

gcactttgat attccaggtg tgattttctc tgtcatgggg atttgctcca ctgcagagcc     4800

ccatcatttt cacagcgtag gccaacagag tgagaaccta gggctaccct agctgatgga     4860

tgtgaggctg ctgtctacag gagctcatcc cagccctgtt aactggcagt ggcaaggata     4920

ctcgtcatcg gccattgcac tggggaactc cctcacccca tggcttccca acttgaaacc     4980

cagatttacc tccagggaga ggtgagaaaa aaattgtaaa tagacttgct aaagagcaac     5040

tcagggttgg ggtgtgtttt aattctcctg atcacttgaa ataatctgta ggctgagtgc     5100

ttatgggggt gggggagaag ggtgactcca gggtccttcc attttgtgaa gctctggggg     5160

tggagtgtgg gcatctgagg ccctatgatg gcactacatt gagctgtctg cccttccgga     5220

aacccaacct gcaatcaact gcaaatcaaa ttcttcacat tccagctaca gtctttcttt     5280

ccccattgaa tctcagtccc tggccatgtg gtcaaggtgg ctttctgtta agctacccta     5340

atttcgggaa tgggagggga gagaggaggg ccattacaac tctgccttca agactcatct     5400

cttaaaaaca aaacgaaaca aaactacaac caccatcaaa accacacgca aaaaaaaaaa     5460

aaaaaaaaaa aaggataact ttaaccgaag gaagggtttg gttccattca actccacatt     5520

cattg                                                                 5525


<210>  541
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Thr Phe His Gln Ala Asn Thr Glu Gln Pro Lys Leu Ser Arg Asp 
            20                  25                  30          


Glu Gln Arg Gly Arg Gly Ala Leu Leu Gln Asp Ile Cys Lys Gly Thr 
        35                  40                  45              


Lys Leu Lys Lys Val Thr Asn Ile Asn Asp Arg Ser Ala Pro Ile Leu 
    50                  55                  60                  


Glu Lys Pro Lys Gly Ser Ser Gly Gly Tyr Gly Ser Gly Gly Ala Ala 
65                  70                  75                  80  


Leu Gln Pro Lys Gly Gly Leu Phe Gln Gly Gly Val Leu Lys Leu Arg 
                85                  90                  95      


Pro Val Gly Ala Lys Asp Gly Ser Glu Asn Leu Ala Gly Lys Pro Ala 
            100                 105                 110         


Leu Gln Ile Pro Ser Ser Arg Ala Ala Ala Pro Arg Pro Pro Val Ser 
        115                 120                 125             


Ala Ala Ser Gly Arg Pro Gln Asp Asp Thr Asp Ser Ser Arg Ala Ser 
    130                 135                 140                 


Leu Pro Glu Leu Pro Arg Met Gln Arg Pro Ser Leu Pro Asp Leu Ser 
145                 150                 155                 160 


Arg Pro Asn Thr Thr Ser Ser Thr Gly Met Lys His Ser Ser Ser Ala 
                165                 170                 175     


Pro Pro Pro Pro Pro Pro Gly Arg Arg Ala Asn Ala Pro Pro Thr Pro 
            180                 185                 190         


Leu Pro Met His Ser Ser Lys Ala Pro Ala Tyr Asn Arg Glu Lys Pro 
        195                 200                 205             


Leu Pro Pro Thr Pro Gly Gln Arg Leu His Pro Gly Arg Glu Gly Pro 
    210                 215                 220                 


Pro Ala Pro Pro Pro Val Lys Pro Pro Pro Ser Pro Val Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Pro Ser Gly Gln Ser Leu Ala Pro Pro Pro Pro Pro Tyr Arg 
                245                 250                 255     


Gln Pro Pro Gly Val Pro Asn Gly Pro Ser Ser Pro Thr Asn Glu Ser 
            260                 265                 270         


Ala Pro Glu Leu Pro Gln Arg His Asn Ser Leu His Arg Lys Thr Pro 
        275                 280                 285             


Gly Pro Val Arg Gly Leu Ala Pro Pro Pro Pro Thr Ser Ala Ser Pro 
    290                 295                 300                 


Ser Leu Leu Ser Asn Arg Pro Pro Pro Pro Ala Arg Asp Pro Pro Ser 
305                 310                 315                 320 


Arg Gly Ala Ala Pro Pro Pro Pro Pro Pro Val Ile Arg Asn Gly Ala 
                325                 330                 335     


Arg Asp Ala Pro Pro Pro Pro Pro Pro Tyr Arg Met His Gly Ser Glu 
            340                 345                 350         


Pro Pro Ser Arg Gly Lys Pro Pro Pro Pro Pro Ser Arg Thr Pro Ala 
        355                 360                 365             


Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Arg Asn Gly His Arg Asp 
    370                 375                 380                 


Ser Ile Thr Thr Val Arg Ser Phe Leu Asp Asp Phe Glu Ser Lys Tyr 
385                 390                 395                 400 


Ser Phe His Pro Val Glu Asp Phe Pro Ala Pro Glu Glu Tyr Lys His 
                405                 410                 415     


Phe Gln Arg Ile Tyr Pro Ser Lys Thr Asn Arg Ala Ala Arg Gly Ala 
            420                 425                 430         


Pro Pro Leu Pro Pro Ile Leu Arg 
        435                 440 


<210>  542
<211>  2300
<212>  DNA
<213>  Homo sapiens

<400>  542
cacttccggg acggtgttcc ggcccattcc ggcccatttc cacccccgga gctctcaccc       60

ctccagtgcc gacggtagcg aaagactttc ctccaggggc ttcctcactg gggaattgcc      120

ggaaagagca aacaaaaaag gcgctggtgt aggctccaaa ataaacacat ctgaattcat      180

gatggcatcg acagaggctc ttattggatt aaaagtttca aaacaaacaa taacgctttg      240

gaaaaagcag ggttgaatgc accctcaggc acgaccatgg agaaaggtgg gaacatacaa      300

ttggagattc ctgacttcag caactctgtc ctgagccatc taaaccagtt gcgcatgcag      360

ggccgtctct gtgatattgt ggtcaatgtg caaggacaag cttttcgggc tcacaaagtg      420

gtgctggctg ccagctcccc ctatttccgg gatcacatgt ccttgaatga gatgagtaca      480

gtctccattt cagtcatcaa gaaccctact gtttttgaac agctcctttc tttctgttac      540

acagggcgga tatgcctgca actggcagat atcatcagct acctaacagc tgccagtttt      600

ctgcaaatgc agcatattat agacaaatgt acacagatcc tggagggcat tcatttcaaa      660

attaatgtgg ctgaggttga agcagaatta agtcaaacaa ggacaaagca tcaagagaga      720

cctccagagt ctcacagggt tacaccaaat ctcaaccgct cccttagccc acgacataat      780

accccaaagg gaaaccggcg aggtcaggtt agtgctgtgc tggatatcag agagctaagt      840

cctcctgagg agtccaccag ccctcagatc attgaaccaa gttctgatgt agagagccgg      900

gagcccattc ttcggatcaa ccgagcagga cagtggtatg tggagacagg agtggcggac      960

cgtgggggtc ggagtgatga tgaagttaga gttcttggag cagtacacat caaaactgaa     1020

aatctggagg agtggcttgg gcctgagaat cagccttctg gagaagatgg gagtagtgca     1080

gaggaagtaa cagccatggt gattgatacc acaggccatg gttctgtagg acaggaaaat     1140

tatactttag ggtcttcagg agccaaggtg gctcggccaa caagcagtga agttgacaga     1200

tttagcccct ccggcagtgt tgttcccttg acagagagac acagagccag aagtgagtct     1260

cctgggagaa tggatgagcc taagcaaccc agctcccagg tagaagagtc agcaatgatg     1320

ggagtaagtg gctatgtgga gtatctccga gagcaggaag tatctgagcg gtggttccgg     1380

tacaaccctc gtctcacctg catctattgc gccaaatctt tcaaccagaa gggaagcctg     1440

gaccgccaca tgcgcctaca catggggatc acaccattcg tctgccgcat gtgtggcaag     1500

aagtataccc ggaaagatca gctggagtat catatccgca agcacacagg caacaagccc     1560

tttcactgtc atgtctgtgg caaaagtttc cccttccagg ccatcttgaa tcagcacttt     1620

cgcaaaaacc accctggctg tatacccctg gaggggcctc acagcatctc ccctgaaaca     1680

actgtcacat ctcgaggaca agctgaggaa gagtcacctt cacaggaaga gacagttgct     1740

cctggggaag ctgtccaggg ctctgtgtcc accactgggc cagactgaaa catccagggg     1800

gagggggctg accctcttcc cctatgagcc ataagcagcc agcatcagag ccatgggctg     1860

atacttagat tcacaaaatg ccacatcact aggccagaag atgctcccaa gatgttgcca     1920

aactggagga tcagcaactt acacaaaagc actaaaggct cctcccttct tattgcccgc     1980

ctcacacttt ggaaaataat caagcaaatc aactttctaa ttcagggatc aacagccttg     2040

gtttgttaac tttataagaa aaaaggtttt ttaacaaaac gatgatgata aatggtcatt     2100

tatctatcag tcatgtttga acactgtact ttggtccata tcatcttggt ggctataatt     2160

gcccggatct aaaaaatgca gcaggagcct caaccatccg aagcagccaa ccgcaagaga     2220

ggaggtagtc atgatggtga tgaggaggag aaatttctcc tcttccttcc ctggcataac     2280

atgcattttt gtgtttcaag                                                 2300


<210>  543
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  543

Met Glu Lys Gly Gly Asn Ile Gln Leu Glu Ile Pro Asp Phe Ser Asn 
1               5                   10                  15      


Ser Val Leu Ser His Leu Asn Gln Leu Arg Met Gln Gly Arg Leu Cys 
            20                  25                  30          


Asp Ile Val Val Asn Val Gln Gly Gln Ala Phe Arg Ala His Lys Val 
        35                  40                  45              


Val Leu Ala Ala Ser Ser Pro Tyr Phe Arg Asp His Met Ser Leu Asn 
    50                  55                  60                  


Glu Met Ser Thr Val Ser Ile Ser Val Ile Lys Asn Pro Thr Val Phe 
65                  70                  75                  80  


Glu Gln Leu Leu Ser Phe Cys Tyr Thr Gly Arg Ile Cys Leu Gln Leu 
                85                  90                  95      


Ala Asp Ile Ile Ser Tyr Leu Thr Ala Ala Ser Phe Leu Gln Met Gln 
            100                 105                 110         


His Ile Ile Asp Lys Cys Thr Gln Ile Leu Glu Gly Ile His Phe Lys 
        115                 120                 125             


Ile Asn Val Ala Glu Val Glu Ala Glu Leu Ser Gln Thr Arg Thr Lys 
    130                 135                 140                 


His Gln Glu Arg Pro Pro Glu Ser His Arg Val Thr Pro Asn Leu Asn 
145                 150                 155                 160 


Arg Ser Leu Ser Pro Arg His Asn Thr Pro Lys Gly Asn Arg Arg Gly 
                165                 170                 175     


Gln Val Ser Ala Val Leu Asp Ile Arg Glu Leu Ser Pro Pro Glu Glu 
            180                 185                 190         


Ser Thr Ser Pro Gln Ile Ile Glu Pro Ser Ser Asp Val Glu Ser Arg 
        195                 200                 205             


Glu Pro Ile Leu Arg Ile Asn Arg Ala Gly Gln Trp Tyr Val Glu Thr 
    210                 215                 220                 


Gly Val Ala Asp Arg Gly Gly Arg Ser Asp Asp Glu Val Arg Val Leu 
225                 230                 235                 240 


Gly Ala Val His Ile Lys Thr Glu Asn Leu Glu Glu Trp Leu Gly Pro 
                245                 250                 255     


Glu Asn Gln Pro Ser Gly Glu Asp Gly Ser Ser Ala Glu Glu Val Thr 
            260                 265                 270         


Ala Met Val Ile Asp Thr Thr Gly His Gly Ser Val Gly Gln Glu Asn 
        275                 280                 285             


Tyr Thr Leu Gly Ser Ser Gly Ala Lys Val Ala Arg Pro Thr Ser Ser 
    290                 295                 300                 


Glu Val Asp Arg Phe Ser Pro Ser Gly Ser Val Val Pro Leu Thr Glu 
305                 310                 315                 320 


Arg His Arg Ala Arg Ser Glu Ser Pro Gly Arg Met Asp Glu Pro Lys 
                325                 330                 335     


Gln Pro Ser Ser Gln Val Glu Glu Ser Ala Met Met Gly Val Ser Gly 
            340                 345                 350         


Tyr Val Glu Tyr Leu Arg Glu Gln Glu Val Ser Glu Arg Trp Phe Arg 
        355                 360                 365             


Tyr Asn Pro Arg Leu Thr Cys Ile Tyr Cys Ala Lys Ser Phe Asn Gln 
    370                 375                 380                 


Lys Gly Ser Leu Asp Arg His Met Arg Leu His Met Gly Ile Thr Pro 
385                 390                 395                 400 


Phe Val Cys Arg Met Cys Gly Lys Lys Tyr Thr Arg Lys Asp Gln Leu 
                405                 410                 415     


Glu Tyr His Ile Arg Lys His Thr Gly Asn Lys Pro Phe His Cys His 
            420                 425                 430         


Val Cys Gly Lys Ser Phe Pro Phe Gln Ala Ile Leu Asn Gln His Phe 
        435                 440                 445             


Arg Lys Asn His Pro Gly Cys Ile Pro Leu Glu Gly Pro His Ser Ile 
    450                 455                 460                 


Ser Pro Glu Thr Thr Val Thr Ser Arg Gly Gln Ala Glu Glu Glu Ser 
465                 470                 475                 480 


Pro Ser Gln Glu Glu Thr Val Ala Pro Gly Glu Ala Val Gln Gly Ser 
                485                 490                 495     


Val Ser Thr Thr Gly Pro Asp 
            500             


<210>  544
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  544
cacttccggg acggtgttcc ggcccattcc ggcccatttc cacccccgga gctctcaccc       60

ctccagtgcc gacggtagcg aaagactttc ctccaggggc ttcctcactg gggaattgcc      120

ggaaagagca aacaaaaaag gcgctggtgt aggctccaaa ataaacacat ctgaattcat      180

gatggcatcg acagaggctc ttattggatt aaaagtttca aaacaaacaa taacgctttg      240

gaaaaagggt tgaatgcacc ctcaggcacg accatggaga aaggtgggaa catacaattg      300

gagattcctg acttcagcaa ctctgtcctg agccatctaa accagttgcg catgcagggc      360

cgtctctgtg atattgtggt caatgtgcaa ggacaagctt ttcgggctca caaagtggtg      420

ctggctgcca gctcccccta tttccgggat cacatgtcct tgaatgagat gagtacagtc      480

tccatttcag tcatcaagaa ccctactgtt tttgaacagc tcctttcttt ctgttacaca      540

gggcggatat gcctgcaact ggcagatatc atcagctacc taacagctgc cagttttctg      600

caaatgcagc atattataga caaatgtaca cagatcctgg agggcattca tttcaaaatt      660

aatgtggctg aggttgaagc agaattaagt caaacaagga caaagcatca agagagacct      720

ccagagtctc acagggttac accaaatctc aaccgctccc ttagcccacg acataatacc      780

ccaaagggaa accggcgagg tcaggttagt gctgtgctgg atatcagaga gctaagtcct      840

cctgaggagt ccaccagccc tcagatcatt gaaccaagtt ctgatgtaga gagccgggag      900

cccattcttc ggatcaaccg agcaggacag tggtatgtgg agacaggagt ggcggaccgt      960

gggggtcgga gtgatgatga agttagagtt cttggagcag tacacatcaa aactgaaaat     1020

ctggaggagt ggcttgggcc tgagaatcag ccttctggag aagatgggag tagtgcagag     1080

gaagtaacag ccatggtgat tgataccaca ggccatggtt ctgtaggaca ggaaaattat     1140

actttagggt cttcaggagc caaggtggct cggccaacaa gcagtgaagt tgacagattt     1200

agcccctccg gcagtgttgt tcccttgaca gagagacaca gagccagaag tgagtctcct     1260

gggagaatgg atgagcctaa gcaacccagc tcccaggtat ggagttgtgg atttagaact     1320

gctttggtgg ttggaggaat tgctactgtg tatgaataga aaataatgaa aaaaaaaaaa     1380

aaaaaa                                                                1386


<210>  545
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  545

Met Glu Lys Gly Gly Asn Ile Gln Leu Glu Ile Pro Asp Phe Ser Asn 
1               5                   10                  15      


Ser Val Leu Ser His Leu Asn Gln Leu Arg Met Gln Gly Arg Leu Cys 
            20                  25                  30          


Asp Ile Val Val Asn Val Gln Gly Gln Ala Phe Arg Ala His Lys Val 
        35                  40                  45              


Val Leu Ala Ala Ser Ser Pro Tyr Phe Arg Asp His Met Ser Leu Asn 
    50                  55                  60                  


Glu Met Ser Thr Val Ser Ile Ser Val Ile Lys Asn Pro Thr Val Phe 
65                  70                  75                  80  


Glu Gln Leu Leu Ser Phe Cys Tyr Thr Gly Arg Ile Cys Leu Gln Leu 
                85                  90                  95      


Ala Asp Ile Ile Ser Tyr Leu Thr Ala Ala Ser Phe Leu Gln Met Gln 
            100                 105                 110         


His Ile Ile Asp Lys Cys Thr Gln Ile Leu Glu Gly Ile His Phe Lys 
        115                 120                 125             


Ile Asn Val Ala Glu Val Glu Ala Glu Leu Ser Gln Thr Arg Thr Lys 
    130                 135                 140                 


His Gln Glu Arg Pro Pro Glu Ser His Arg Val Thr Pro Asn Leu Asn 
145                 150                 155                 160 


Arg Ser Leu Ser Pro Arg His Asn Thr Pro Lys Gly Asn Arg Arg Gly 
                165                 170                 175     


Gln Val Ser Ala Val Leu Asp Ile Arg Glu Leu Ser Pro Pro Glu Glu 
            180                 185                 190         


Ser Thr Ser Pro Gln Ile Ile Glu Pro Ser Ser Asp Val Glu Ser Arg 
        195                 200                 205             


Glu Pro Ile Leu Arg Ile Asn Arg Ala Gly Gln Trp Tyr Val Glu Thr 
    210                 215                 220                 


Gly Val Ala Asp Arg Gly Gly Arg Ser Asp Asp Glu Val Arg Val Leu 
225                 230                 235                 240 


Gly Ala Val His Ile Lys Thr Glu Asn Leu Glu Glu Trp Leu Gly Pro 
                245                 250                 255     


Glu Asn Gln Pro Ser Gly Glu Asp Gly Ser Ser Ala Glu Glu Val Thr 
            260                 265                 270         


Ala Met Val Ile Asp Thr Thr Gly His Gly Ser Val Gly Gln Glu Asn 
        275                 280                 285             


Tyr Thr Leu Gly Ser Ser Gly Ala Lys Val Ala Arg Pro Thr Ser Ser 
    290                 295                 300                 


Glu Val Asp Arg Phe Ser Pro Ser Gly Ser Val Val Pro Leu Thr Glu 
305                 310                 315                 320 


Arg His Arg Ala Arg Ser Glu Ser Pro Gly Arg Met Asp Glu Pro Lys 
                325                 330                 335     


Gln Pro Ser Ser Gln Val Trp Ser Cys Gly Phe Arg Thr Ala Leu Val 
            340                 345                 350         


Val Gly Gly Ile Ala Thr Val Tyr Glu 
        355                 360     


<210>  546
<211>  6131
<212>  DNA
<213>  Homo sapiens

<400>  546
ctccgactct cggcacctgg cctccagctt tcggaactat ggaggccgcg cccgggaccc       60

ccccgccgcc gccatcagag tcgccgccgc cgccatcgcc gccgccgcca tcaacgcctt      120

cgcctcctcc gtgttccccc gacgcccgcc cggccacccc gcacctcctc caccaccgcc      180

tcccgctccc tgacgacagg gaagatggag agttggaaga aggtgaattg gaagatgatg      240

gggcagagga gacccaggat acctccggag ggcctgagag aagccggaaa gaaaaggggg      300

agaagcatca cagtgattcg gatgaggaga agtcccacag gagactgaag cggaaacgga      360

agaaagagcg ggagaaagag aaaaggaggt cgaagaagag gaggaaatcc aagcacaaac      420

gccatgcttc ttctagcgat gacttctctg acttctcaga tgactcggat ttcagcccca      480

gtgagaaagg tcaccgcaag tacagagagt acagcccccc atatgcgccg tcccaccagc      540

agtacccccc atcgcatgcc acgcccctgc ccaagaaggc atactccaag atggacagca      600

agagttatgg catgtacgag gactacgaga atgagcagta tggggaatat gagggcgacg      660

aggaggagga catgggcaag gaggactatg acgacttcac caaagagctg aaccagtacc      720

ggcgtgccaa ggagggcagc agccgcggcc gaggcagccg aggccggggc cggggctaca      780

ggggccgagg aagccgtgga ggatcgcgag gccgcggcat gggcaggggc agccgaggca      840

ggggcagagg ctctatggga ggagaccacc cggaggatga agaggatttc tacgaggaag      900

agatggacta tggagagagt gaggagccaa tgggagacga cgactatgac gagtactcca      960

aggagctgaa ccagtaccgc cgctccaagg acagccgagg ccgagggcta agtcgaggcc     1020

gtggcagggg ctcccgaggt cgagggaaag gaatgggtcg gggccgaggc cgaggtggca     1080

gccgaggagg gatgaacaag ggcggaatga acgatgacga agacttctat gacgaggaca     1140

tgggcgacgg tggtggtgga agctaccgga gtcgtgacca tgacaagccc caccagcagt     1200

cggacaagaa aggcaaagtc atttgcaagt acttcgtgga agggcgctgc acctggggag     1260

accactgtaa ttttagccat gacatcgaac tcccaaagaa gcgagaactg tgcaagtttt     1320

acatcactgg attttgcgcc agagctgaga actgccctta tatgcacggt gatttcccgt     1380

gtaagctgta ccacaccact gggaactgca tcaatggtga cgactgcatg ttttcccacg     1440

accctctgac cgaagagacg agggagctct tggataagat gttggccgat gatgcagaag     1500

caggtgccga ggatgagaag gaggtggagg aactgaagaa gcagggcatc aaccccctgc     1560

ccaaaccgcc ccctggtgtg ggcctcctgc ccacccctcc tcggccccct ggcccgcagg     1620

ctccaacctc tcccaacggc aggcccatgc agggtggccc cccgcccccg ccccctcccc     1680

ctcccccacc gcccgggccc cctcagatgc ccatgccggt gcatgagcca ctgtccccgc     1740

agcagctgca gcagcaggac atgtacaaca agaagatccc ctccttgttt gagatcgtgg     1800

tgcggcccac gggacagctg gctgagaagc tgggtgtgag gttccctgga cccggtggac     1860

ccccagggcc aatgggccct gggcccaaca tgggaccccc agggccaatg ggcggtccaa     1920

tgcatcctga catgcacccc gacatgcacc cggacatgca ccctgacatg cacgcagaca     1980

tgcacgcaga catgccgatg ggccctggca tgaatcctgg cccacccatg ggccctggcg     2040

gccctccaat gatgccctac ggccctggag actccccaca ttctggaatg atgcccccta     2100

tcccgccagc ccagaacttc tatgaaaact tctaccagca gcaggagggc atggagatgg     2160

agcccggact cctgggggat gcagaggact acgggcacta cgaagagctg ccaggggagc     2220

ctggggagca cctcttccct gagcaccctc tggagcccga cagcttctct gagggagggc     2280

ccccaggccg gccgaagcca ggcgccggtg tccctgactt cctgccctca gcccagaggg     2340

ccctgtacct gaggatccag cagaagcagc aggaggagga ggagagagcg aggaggctgg     2400

ctgagagcag caagcaggac cgggagaatg aggaaggtga caccggaaac tggtactcaa     2460

gtgatgagga tgagggtgga agcagtgtca cctccatcct gaagaccttg aggcagcaga     2520

cgtccagccg acccccggct tcagttgggg agctgagcag cagtgggctg ggggaccccc     2580

gcctccagaa gggacacccc acaggaagcc ggctggctga ccctcgcctc agccgggacc     2640

ccagactcac ccgccatgtg gaggcttctg gcgggtctgg cccaggtgat tcgggaccct     2700

ccgatcctcg gctggctcgc gccctgccca cctccaagcc cgaaggcagc cttcattcca     2760

gccctgtggg ccccagcagt tccaaggggt ctgggccgcc cccaacggag gaggaggaag     2820

gggagcgggc cctgcgggag aaggccgtga acattcccct ggacccactc cccgggcacc     2880

ctctgcggga cccacggtca cagctgcagc agttcagcca catcaagaag gacgtgaccc     2940

tgagcaagcc cagcttcgcc cgcaccgtgc tctggaatcc cgaggacctg atccccctac     3000

ccatccccaa gcaggacgca gtgccccccg tgcccgcggc cctgcaatcc atgcccaccc     3060

tggacccccg gctgcaccgc gctgccacgg cagggccccc caacgcccgg cagcgcccgg     3120

gcgcctccac ggattccagc acacagggcg ccaacctccc cgactttgaa cttctgtctc     3180

gcatcctcaa gacagtcaat gccaccggct cctcggccgc ccccggttcc agcgacaaac     3240

ccagtgaccc ccgggtgcgg aaggccccca ccgaccctcg gctgcagaaa cccacagact     3300

ctacggcctc ctcccgggct gccaagcccg gccctgctga ggcgccctct cccaccgcca     3360

gcccgagtgg ggatgcctcc ccaccagcca ccgctcccta cgacccccgc gtgctggcgg     3420

ccggtggact gggccagggc ggagggggcg ggcagagcag tgtgctgagc ggtatcagcc     3480

tctacgaccc gaggactccc aacgcggggg gcaaagccac agagccggct gctgacacgg     3540

gtgcccagcc caagggtgct gagggcaatg gcaagagctc ggcctccaag gctaaggagc     3600

ccccgttcgt ccgcaagtct gccctggaac agccagagac agggaaggcc ggtgctgatg     3660

ggggcacccc cacggacaga tacaacagct acaaccggcc ccggcccaag gctgctgcag     3720

cccccgctgc caccaccgcc accccacccc ccgagggtgc cccaccccag cccggggtgc     3780

acaacctgcc cgtgcccacc ctcttcggga cggtgaagca gacacccaag acgggctcag     3840

gaagcccatt tgctgggaac agtccggccc gcgagggtga gcaggatgcg gcatccctga     3900

aggatgtttt taaaggcttc gaccccacgg cctccccctt ttgccagtag tgtccagcca     3960

gagctgcggc tccagccacc cttcctaggg tggcattcag ggcagcaccc agggtaggga     4020

acttgggggc aaggggaggc aggctgggtg ttcctttttt cttttctttt tcttttgctt     4080

tccgtctctt ttattttttt ttaaagtagt actttctttg agatttgtaa attgtatata     4140

accatcttaa gttctggtca gtgtggcggg ctcaggggct cctgctgagc aaaccgactc     4200

atgcccgcaa acctgtgaac tttcgccagt gcctggcctc agactctgtg ggctctgcgt     4260

ggccgggcct tgctggaggc ccagtgggtt ttctgggcaa agcatggccc cttttcccca     4320

ggacaaaggg aacagttggt gtctgggaag gtattgaacg ctcctcaccc tgtgcccgaa     4380

gagacccgga accaagacca tggcagggcc tgcgtggaag caggtccagg cgtttctaga     4440

accctagggt gcaccatcac tgtcttttca gtgcaggctg taacaaccca ctcaggagac     4500

agtgagagtg aaaaggtatt aaggaaaaag cccccagcgg cactatgggg gctccctggc     4560

gcatgcctgc tcctgtccct ggattaccac acgtgccctc cctgccaccc tccgtctaga     4620

gcaagcggat gccccccagc ctgcagcaga agcctccaca gtgagaactg gacccaaagg     4680

tagtgggggc cggtgtgggg cagagtcctg aagagccacc tctaggaggc agcccctagg     4740

agcacgcacg ttctgtcagt attaccccac ctgtcctatc aggtgggcca caccctgctt     4800

gcccacacca gggtctgtcc tggtcctcaa gccacgcacc cgctatgcct gcactgcagc     4860

ccagccccgg acagctccag gatccgtgca gtggctgcgc cgccaggccc caacaatggg     4920

gaccctgggg tggctcctgg ccaagtgttc tctgttttcc tcgcacctcc ttacactgtg     4980

tgacctgcag ggcatgaggt attgatgtgt tcgggtttcc tttcccaagc cagcagatgc     5040

aggtgttcca aggtgtgttg ctctgtggga tttgtggaca cttaagaaac ggactgagtg     5100

ggaaccctgc agccagggga tggggagcct ctgctccccc catgctccca ccctggctga     5160

gggccagcct catctgcaga gccctggagg aggcccacct atggacacag cccgagagat     5220

gggcgcaagg ggtgctgggg gaggcctgct atcctgcctc tgggccactt gaggggcctc     5280

aggaagtgtg tgcttgtggc tgcatctgcc cgtctccctg gcccaccatg tggctgcagg     5340

ccaagctctt cattgctgac catgaagaga cctagttacc tgccaaggga ttccccttcc     5400

ctcctcctca gggtggggtg aacaaggctc ctatcccacc ccaccccaaa aagagaaaaa     5460

tgaaaaactc atagtttgga gccaggaggc agggtgtcct acagggctgc acagccctga     5520

ggggtcagtg ctgggatctg gttggttggt ttgtcttttt gtcttttttt tttttttttt     5580

ttttacacaa tcattaatga gatttgtctt cagccaccag tgttggcctt gaagcagagg     5640

gcacagccct tggtgtttgt aaaataagta tgaatacaca gtgtggcagt gttgtggttt     5700

ttgttgttgt ttttcctctc cttttgagaa ttttcttttg taaaagaaaa atatttttta     5760

aaccgaaatc tgtggatgaa atagaagctg gagccctcct cttggaatat tcagcctaag     5820

aacctcatag gactatgaat tcacccgaaa ttctcatttg ccatcaggcc gagcttttaa     5880

agaaaaattg ttctctaacc aggattgtaa caaaagtgta aatactgttt cagagttgag     5940

agttggtggt gcaaatatgt atataatgaa ctgtattttt acaatgatcg ccgcatgact     6000

atttcacacc ctttttatac tccatatctg tcttccagaa acgtcacctg cctttctcct     6060

gtggtctctt aatccagtaa ttgtattact gccattaaag gatgcagtta ttttaaaaaa     6120

aaaaaaaaaa a                                                          6131


<210>  547
<211>  1303
<212>  PRT
<213>  Homo sapiens

<400>  547

Met Glu Ala Ala Pro Gly Thr Pro Pro Pro Pro Pro Ser Glu Ser Pro 
1               5                   10                  15      


Pro Pro Pro Ser Pro Pro Pro Pro Ser Thr Pro Ser Pro Pro Pro Cys 
            20                  25                  30          


Ser Pro Asp Ala Arg Pro Ala Thr Pro His Leu Leu His His Arg Leu 
        35                  40                  45              


Pro Leu Pro Asp Asp Arg Glu Asp Gly Glu Leu Glu Glu Gly Glu Leu 
    50                  55                  60                  


Glu Asp Asp Gly Ala Glu Glu Thr Gln Asp Thr Ser Gly Gly Pro Glu 
65                  70                  75                  80  


Arg Ser Arg Lys Glu Lys Gly Glu Lys His His Ser Asp Ser Asp Glu 
                85                  90                  95      


Glu Lys Ser His Arg Arg Leu Lys Arg Lys Arg Lys Lys Glu Arg Glu 
            100                 105                 110         


Lys Glu Lys Arg Arg Ser Lys Lys Arg Arg Lys Ser Lys His Lys Arg 
        115                 120                 125             


His Ala Ser Ser Ser Asp Asp Phe Ser Asp Phe Ser Asp Asp Ser Asp 
    130                 135                 140                 


Phe Ser Pro Ser Glu Lys Gly His Arg Lys Tyr Arg Glu Tyr Ser Pro 
145                 150                 155                 160 


Pro Tyr Ala Pro Ser His Gln Gln Tyr Pro Pro Ser His Ala Thr Pro 
                165                 170                 175     


Leu Pro Lys Lys Ala Tyr Ser Lys Met Asp Ser Lys Ser Tyr Gly Met 
            180                 185                 190         


Tyr Glu Asp Tyr Glu Asn Glu Gln Tyr Gly Glu Tyr Glu Gly Asp Glu 
        195                 200                 205             


Glu Glu Asp Met Gly Lys Glu Asp Tyr Asp Asp Phe Thr Lys Glu Leu 
    210                 215                 220                 


Asn Gln Tyr Arg Arg Ala Lys Glu Gly Ser Ser Arg Gly Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Arg Gly Arg Gly Tyr Arg Gly Arg Gly Ser Arg Gly Gly Ser 
                245                 250                 255     


Arg Gly Arg Gly Met Gly Arg Gly Ser Arg Gly Arg Gly Arg Gly Ser 
            260                 265                 270         


Met Gly Gly Asp His Pro Glu Asp Glu Glu Asp Phe Tyr Glu Glu Glu 
        275                 280                 285             


Met Asp Tyr Gly Glu Ser Glu Glu Pro Met Gly Asp Asp Asp Tyr Asp 
    290                 295                 300                 


Glu Tyr Ser Lys Glu Leu Asn Gln Tyr Arg Arg Ser Lys Asp Ser Arg 
305                 310                 315                 320 


Gly Arg Gly Leu Ser Arg Gly Arg Gly Arg Gly Ser Arg Gly Arg Gly 
                325                 330                 335     


Lys Gly Met Gly Arg Gly Arg Gly Arg Gly Gly Ser Arg Gly Gly Met 
            340                 345                 350         


Asn Lys Gly Gly Met Asn Asp Asp Glu Asp Phe Tyr Asp Glu Asp Met 
        355                 360                 365             


Gly Asp Gly Gly Gly Gly Ser Tyr Arg Ser Arg Asp His Asp Lys Pro 
    370                 375                 380                 


His Gln Gln Ser Asp Lys Lys Gly Lys Val Ile Cys Lys Tyr Phe Val 
385                 390                 395                 400 


Glu Gly Arg Cys Thr Trp Gly Asp His Cys Asn Phe Ser His Asp Ile 
                405                 410                 415     


Glu Leu Pro Lys Lys Arg Glu Leu Cys Lys Phe Tyr Ile Thr Gly Phe 
            420                 425                 430         


Cys Ala Arg Ala Glu Asn Cys Pro Tyr Met His Gly Asp Phe Pro Cys 
        435                 440                 445             


Lys Leu Tyr His Thr Thr Gly Asn Cys Ile Asn Gly Asp Asp Cys Met 
    450                 455                 460                 


Phe Ser His Asp Pro Leu Thr Glu Glu Thr Arg Glu Leu Leu Asp Lys 
465                 470                 475                 480 


Met Leu Ala Asp Asp Ala Glu Ala Gly Ala Glu Asp Glu Lys Glu Val 
                485                 490                 495     


Glu Glu Leu Lys Lys Gln Gly Ile Asn Pro Leu Pro Lys Pro Pro Pro 
            500                 505                 510         


Gly Val Gly Leu Leu Pro Thr Pro Pro Arg Pro Pro Gly Pro Gln Ala 
        515                 520                 525             


Pro Thr Ser Pro Asn Gly Arg Pro Met Gln Gly Gly Pro Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Gln Met Pro Met Pro 
545                 550                 555                 560 


Val His Glu Pro Leu Ser Pro Gln Gln Leu Gln Gln Gln Asp Met Tyr 
                565                 570                 575     


Asn Lys Lys Ile Pro Ser Leu Phe Glu Ile Val Val Arg Pro Thr Gly 
            580                 585                 590         


Gln Leu Ala Glu Lys Leu Gly Val Arg Phe Pro Gly Pro Gly Gly Pro 
        595                 600                 605             


Pro Gly Pro Met Gly Pro Gly Pro Asn Met Gly Pro Pro Gly Pro Met 
    610                 615                 620                 


Gly Gly Pro Met His Pro Asp Met His Pro Asp Met His Pro Asp Met 
625                 630                 635                 640 


His Pro Asp Met His Ala Asp Met His Ala Asp Met Pro Met Gly Pro 
                645                 650                 655     


Gly Met Asn Pro Gly Pro Pro Met Gly Pro Gly Gly Pro Pro Met Met 
            660                 665                 670         


Pro Tyr Gly Pro Gly Asp Ser Pro His Ser Gly Met Met Pro Pro Ile 
        675                 680                 685             


Pro Pro Ala Gln Asn Phe Tyr Glu Asn Phe Tyr Gln Gln Gln Glu Gly 
    690                 695                 700                 


Met Glu Met Glu Pro Gly Leu Leu Gly Asp Ala Glu Asp Tyr Gly His 
705                 710                 715                 720 


Tyr Glu Glu Leu Pro Gly Glu Pro Gly Glu His Leu Phe Pro Glu His 
                725                 730                 735     


Pro Leu Glu Pro Asp Ser Phe Ser Glu Gly Gly Pro Pro Gly Arg Pro 
            740                 745                 750         


Lys Pro Gly Ala Gly Val Pro Asp Phe Leu Pro Ser Ala Gln Arg Ala 
        755                 760                 765             


Leu Tyr Leu Arg Ile Gln Gln Lys Gln Gln Glu Glu Glu Glu Arg Ala 
    770                 775                 780                 


Arg Arg Leu Ala Glu Ser Ser Lys Gln Asp Arg Glu Asn Glu Glu Gly 
785                 790                 795                 800 


Asp Thr Gly Asn Trp Tyr Ser Ser Asp Glu Asp Glu Gly Gly Ser Ser 
                805                 810                 815     


Val Thr Ser Ile Leu Lys Thr Leu Arg Gln Gln Thr Ser Ser Arg Pro 
            820                 825                 830         


Pro Ala Ser Val Gly Glu Leu Ser Ser Ser Gly Leu Gly Asp Pro Arg 
        835                 840                 845             


Leu Gln Lys Gly His Pro Thr Gly Ser Arg Leu Ala Asp Pro Arg Leu 
    850                 855                 860                 


Ser Arg Asp Pro Arg Leu Thr Arg His Val Glu Ala Ser Gly Gly Ser 
865                 870                 875                 880 


Gly Pro Gly Asp Ser Gly Pro Ser Asp Pro Arg Leu Ala Arg Ala Leu 
                885                 890                 895     


Pro Thr Ser Lys Pro Glu Gly Ser Leu His Ser Ser Pro Val Gly Pro 
            900                 905                 910         


Ser Ser Ser Lys Gly Ser Gly Pro Pro Pro Thr Glu Glu Glu Glu Gly 
        915                 920                 925             


Glu Arg Ala Leu Arg Glu Lys Ala Val Asn Ile Pro Leu Asp Pro Leu 
    930                 935                 940                 


Pro Gly His Pro Leu Arg Asp Pro Arg Ser Gln Leu Gln Gln Phe Ser 
945                 950                 955                 960 


His Ile Lys Lys Asp Val Thr Leu Ser Lys Pro Ser Phe Ala Arg Thr 
                965                 970                 975     


Val Leu Trp Asn Pro Glu Asp Leu Ile Pro Leu Pro Ile Pro Lys Gln 
            980                 985                 990         


Asp Ala Val Pro Pro Val Pro Ala  Ala Leu Gln Ser Met  Pro Thr Leu 
        995                 1000                 1005             


Asp Pro  Arg Leu His Arg Ala  Ala Thr Ala Gly Pro  Pro Asn Ala 
    1010                 1015                 1020             


Arg Gln  Arg Pro Gly Ala Ser  Thr Asp Ser Ser Thr  Gln Gly Ala 
    1025                 1030                 1035             


Asn Leu  Pro Asp Phe Glu Leu  Leu Ser Arg Ile Leu  Lys Thr Val 
    1040                 1045                 1050             


Asn Ala  Thr Gly Ser Ser Ala  Ala Pro Gly Ser Ser  Asp Lys Pro 
    1055                 1060                 1065             


Ser Asp  Pro Arg Val Arg Lys  Ala Pro Thr Asp Pro  Arg Leu Gln 
    1070                 1075                 1080             


Lys Pro  Thr Asp Ser Thr Ala  Ser Ser Arg Ala Ala  Lys Pro Gly 
    1085                 1090                 1095             


Pro Ala  Glu Ala Pro Ser Pro  Thr Ala Ser Pro Ser  Gly Asp Ala 
    1100                 1105                 1110             


Ser Pro  Pro Ala Thr Ala Pro  Tyr Asp Pro Arg Val  Leu Ala Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Gln Gly Gly  Gly Gly Gly Gln Ser  Ser Val Leu 
    1130                 1135                 1140             


Ser Gly  Ile Ser Leu Tyr Asp  Pro Arg Thr Pro Asn  Ala Gly Gly 
    1145                 1150                 1155             


Lys Ala  Thr Glu Pro Ala Ala  Asp Thr Gly Ala Gln  Pro Lys Gly 
    1160                 1165                 1170             


Ala Glu  Gly Asn Gly Lys Ser  Ser Ala Ser Lys Ala  Lys Glu Pro 
    1175                 1180                 1185             


Pro Phe  Val Arg Lys Ser Ala  Leu Glu Gln Pro Glu  Thr Gly Lys 
    1190                 1195                 1200             


Ala Gly  Ala Asp Gly Gly Thr  Pro Thr Asp Arg Tyr  Asn Ser Tyr 
    1205                 1210                 1215             


Asn Arg  Pro Arg Pro Lys Ala  Ala Ala Ala Pro Ala  Ala Thr Thr 
    1220                 1225                 1230             


Ala Thr  Pro Pro Pro Glu Gly  Ala Pro Pro Gln Pro  Gly Val His 
    1235                 1240                 1245             


Asn Leu  Pro Val Pro Thr Leu  Phe Gly Thr Val Lys  Gln Thr Pro 
    1250                 1255                 1260             


Lys Thr  Gly Ser Gly Ser Pro  Phe Ala Gly Asn Ser  Pro Ala Arg 
    1265                 1270                 1275             


Glu Gly  Glu Gln Asp Ala Ala  Ser Leu Lys Asp Val  Phe Lys Gly 
    1280                 1285                 1290             


Phe Asp  Pro Thr Ala Ser Pro  Phe Cys Gln 
    1295                 1300             


<210>  548
<211>  4373
<212>  DNA
<213>  Homo sapiens

<400>  548
ttttggcgta gattccccac tgatcgaggc attttttttc cctttttttt tccttttttt       60

ttttctttta aaaattttgg ccatcgttct ccgtacgggg gctttttctg tctgtctgtc      120

tggctggcag gctggctttc cccctctttc ccacggagcc cgagccgggc gcccggtggg      180

gagtggggag tgggtggggg gagccagcag agttccattt tggaacgccc gtgccgcgtc      240

tccgcgttcc cagcccgggt ccccgcgttc acagccccag cgcaggtctg gatgtaccga      300

ctgcttttgg aataaaaaga ttcccaggat gtgagcaaca cgggaccgat atgatgcttc      360

ctggtgtgtt tagtggttgg tgccattcca attttctgtg ctgaaatcat tctgaaaact      420

caaacagtag acttcagcac acaaggaaag ccaaagccat ttgaggggga ataaagccaa      480

aagcctttca ccttattcgt tccaagaatc tcaccgcccc ctccttatcc ccctccaaaa      540

ataagccatt gcacacagac aggcagcatg gctagcaaac gaaaatctac aactccatgc      600

atggttcgga catcacaagt agtagaacaa gatgtgcccg aggaagtaga cagggccaaa      660

gagaaaggaa tcggcacacc acagcctgac gtggccaagg acagttgggc agcagaactt      720

gaaaactctt ccaaagaaaa cgaagtgata gaggtgaaat ctatggggga aagccagtcc      780

aaaaaactcc aaggtggtta tgagtgcaaa tactgcccct actccacgca aaacctgaac      840

gagttcacgg agcatgtcga catgcagcat cccaacgtga ttctcaaccc cctctacgtg      900

tgtgcagaat gtaacttcac aaccaaaaag tacgactccc tatccgacca caactccaag      960

ttccatcccg gggaggccaa cttcaagctg aagttaatta aacgcaataa tcaaactgtc     1020

ttggaacagt ccatcgaaac caccaaccat gtcgtgtcca tcaccaccag tggccctgga     1080

actggtgaca gtgattctgg gatctcggtg agtaaaaccc ccatcatgaa gcctggaaaa     1140

ccaaaagcgg atgccaagaa ggtgcccaag aagcccgagg agatcacccc cgagaaccac     1200

gtggaaggga ccgcccgcct ggtgacagac acagctgaga tcctctcgag actcggcggg     1260

gtggagctcc tccaagacac attaggacac gtcatgcctt ctgtacagct gccaccaaat     1320

atcaaccttg tgcccaaggt ccctgtccca ctaaatacta ccaaatacaa ctctgccctg     1380

gatacaaatg ccacgatgat caactctttc aacaagtttc cttacccgac ccaggctgag     1440

ttgtcctggc tgacagctgc ctccaaacac ccagaggagc acatcagaat ctggtttgcc     1500

acccagcgct taaagcatgg catcagctgg tccccagaag aggtggagga ggcccggaag     1560

aagatgttca acggcaccat ccagtcagta cccccgacca tcactgtgct gcccgcccag     1620

ttggccccca caaaggtgac gcagcccatc ctccagacgg ctctaccgtg ccagatcctc     1680

ggccagacta gcctggtgct gactcaggtg accagcgggt caacaaccgt ctcttgctcc     1740

cccatcacac ttgccgtggc aggagtcacc aaccatggcc agaagagacc cttggtgact     1800

ccccaagctg cccccgaacc caagcgtcca cacatcgctc aggtgccaga gcccccaccc     1860

aaggtggcca accccccgct cacaccagcc agtgaccgca agaagacaaa ggagcagata     1920

gcacatctca aggccagctt tctccagagc cagttccctg acgatgccga ggtttaccgg     1980

ctcatcgagg tgactggcct tgccaggagc gagatcaaga agtggttcag tgaccaccga     2040

tatcggtgtc aaaggggcat cgtccacatc accagcgaat cccttgccaa agaccagttg     2100

gccatcgcgg cctcccgaca cggtcgcacg tatcatgcgt acccagactt tgccccccag     2160

aagttcaaag agaaaacaca gggtcaggtt aaaatcttgg aagacagctt tttgaaaagt     2220

tcttttccta cccaagcaga actggatcgg ctaagggtgg agaccaagct gagcaggaga     2280

gagatcgact cctggttctc ggagaggcgg aagcttcgag acagcatgga acaagctgtc     2340

ttggattcca tggggtctgg caaaaaaggc caagatgtgg gagcccccaa tggtgctctg     2400

tctcgactcg accagctctc cggtgcccag ttaacaagtt ctctgcccag cccttcgcca     2460

gcaattgcaa aaagtcaaga acaggttcat ctcctgagga gcacgtttgc aagaacccag     2520

tggcctactc cccaggagta cgaccagtta gcggccaaga ctggcctggt ccgaactgag     2580

attgtgcgtt ggttcaagga gaacagatgc ttgctgaaaa cgggaaccgt gaagtggatg     2640

gagcagtacc agcaccagcc catggcagat gatcacggct acgatgccgt agcaaggaaa     2700

gcaacaaaac ccatggccga gagcccaaag aacgggggtg atgtggttcc acaatattac     2760

aaggacccca aaaagctctg cgaagaggac ttggagaagt tggtgaccag ggtaaaagta     2820

ggcagcgagc cagcaaaaga ctgtttgcca gcaaagccct cagaggccac ctcagaccgg     2880

tcagagggca gcagccggga cggccagggt agcgacgaga acgaggagtc gagcgttgtg     2940

gattacgtgg aggtgacggt cggggaggag gatgcgatct cagatagatc agatagctgg     3000

agtcaggctg cggcagaagg tgtgtcggaa ctggctgaat cagactccga ctgcgtccct     3060

gcagaggctg gccaggccta gacagggaag tctgttagaa ctgctgtgct gatcaacggg     3120

acgctccgtc tttgaagaaa gaagagatgg tctctcccca gccatgggcc acccttgcca     3180

gtgactccaa gtggaactac ttagctcgcg tgtgcctgga gggtgcggga agtccagcga     3240

ctctcagacg cacctcccag aggaccggtg ggaattgttc atagtgccaa agtcctacta     3300

ctgcgttttc aatgggtcct tgtacatagt ttgctcctct gccctagccc tcacctcttg     3360

ctatactgga accgatttgt acaatgtggg aattttgtta cctttttaat caagggcaac     3420

ttccttttcc agcactacca ttgtaaggtt tttttcagga gggagggcta accaccttgc     3480

ttttctcttt tctctttttc ttttttttat ttttgtttta ttaatttggg gaaaggggtg     3540

ttagcattag tgccatgata tctactggat tttaagtagg gagactttat ttttaaaggt     3600

aggttgaaat ttgggagatt tctcggcagg aagggctgaa atccaggccc ctgtctcaac     3660

ttggagagag gtgacagacg gcagatcttc caaatcaaat tcctttccag ttcttcccct     3720

ggctgccttt ttgggggtcc ctgccttagc cccacacaag gctttctgaa ctgccaagag     3780

gggatctggc ttctcaactg ctcggcctct tgggccaggc tgtgcccagc cagccctggg     3840

agaactgggt agcaggtggc tgacttcttt aagcaccttt ctaaatacca gcagaagagg     3900

ctcccgcctc tgttagcatg atcagtacta ttgtgacatt aaaacaacaa caataagatc     3960

ttcctatctg gagggtacag aggtgaatgg ctttggtttt catttctctt cttcactgcc     4020

ttttctcggt gtggtatttg acaagatttt agctcaaagc ctcaccatga attgattttt     4080

tttgtttgtg tgtgtgtttg ttttgggaca attttagata cctgagtgca ctttttcagt     4140

tagtcctaac ttttaaaaga aggaaaacca agagacatat ctggtgtacg tgttgcagta     4200

tgaactctgg ttgcaatccc tccccgtccc acactgcccc ccatttgagt acaccgcaca     4260

agtcaaacgc taggaagttt gaataaaacc aatttttcta acttgttgct catttgttgt     4320

aactcaataa agcaaagact aaacattttt ataaccttta aaaaaaaaaa aaa            4373


<210>  549
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  549

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr Thr Ser Gly Pro Gly Thr Gly Asp Ser Asp 
                165                 170                 175     


Ser Gly Ile Ser Val Ser Lys Thr Pro Ile Met Lys Pro Gly Lys Pro 
            180                 185                 190         


Lys Ala Asp Ala Lys Lys Val Pro Lys Lys Pro Glu Glu Ile Thr Pro 
        195                 200                 205             


Glu Asn His Val Glu Gly Thr Ala Arg Leu Val Thr Asp Thr Ala Glu 
    210                 215                 220                 


Ile Leu Ser Arg Leu Gly Gly Val Glu Leu Leu Gln Asp Thr Leu Gly 
225                 230                 235                 240 


His Val Met Pro Ser Val Gln Leu Pro Pro Asn Ile Asn Leu Val Pro 
                245                 250                 255     


Lys Val Pro Val Pro Leu Asn Thr Thr Lys Tyr Asn Ser Ala Leu Asp 
            260                 265                 270         


Thr Asn Ala Thr Met Ile Asn Ser Phe Asn Lys Phe Pro Tyr Pro Thr 
        275                 280                 285             


Gln Ala Glu Leu Ser Trp Leu Thr Ala Ala Ser Lys His Pro Glu Glu 
    290                 295                 300                 


His Ile Arg Ile Trp Phe Ala Thr Gln Arg Leu Lys His Gly Ile Ser 
305                 310                 315                 320 


Trp Ser Pro Glu Glu Val Glu Glu Ala Arg Lys Lys Met Phe Asn Gly 
                325                 330                 335     


Thr Ile Gln Ser Val Pro Pro Thr Ile Thr Val Leu Pro Ala Gln Leu 
            340                 345                 350         


Ala Pro Thr Lys Val Thr Gln Pro Ile Leu Gln Thr Ala Leu Pro Cys 
        355                 360                 365             


Gln Ile Leu Gly Gln Thr Ser Leu Val Leu Thr Gln Val Thr Ser Gly 
    370                 375                 380                 


Ser Thr Thr Val Ser Cys Ser Pro Ile Thr Leu Ala Val Ala Gly Val 
385                 390                 395                 400 


Thr Asn His Gly Gln Lys Arg Pro Leu Val Thr Pro Gln Ala Ala Pro 
                405                 410                 415     


Glu Pro Lys Arg Pro His Ile Ala Gln Val Pro Glu Pro Pro Pro Lys 
            420                 425                 430         


Val Ala Asn Pro Pro Leu Thr Pro Ala Ser Asp Arg Lys Lys Thr Lys 
        435                 440                 445             


Glu Gln Ile Ala His Leu Lys Ala Ser Phe Leu Gln Ser Gln Phe Pro 
    450                 455                 460                 


Asp Asp Ala Glu Val Tyr Arg Leu Ile Glu Val Thr Gly Leu Ala Arg 
465                 470                 475                 480 


Ser Glu Ile Lys Lys Trp Phe Ser Asp His Arg Tyr Arg Cys Gln Arg 
                485                 490                 495     


Gly Ile Val His Ile Thr Ser Glu Ser Leu Ala Lys Asp Gln Leu Ala 
            500                 505                 510         


Ile Ala Ala Ser Arg His Gly Arg Thr Tyr His Ala Tyr Pro Asp Phe 
        515                 520                 525             


Ala Pro Gln Lys Phe Lys Glu Lys Thr Gln Gly Gln Val Lys Ile Leu 
    530                 535                 540                 


Glu Asp Ser Phe Leu Lys Ser Ser Phe Pro Thr Gln Ala Glu Leu Asp 
545                 550                 555                 560 


Arg Leu Arg Val Glu Thr Lys Leu Ser Arg Arg Glu Ile Asp Ser Trp 
                565                 570                 575     


Phe Ser Glu Arg Arg Lys Leu Arg Asp Ser Met Glu Gln Ala Val Leu 
            580                 585                 590         


Asp Ser Met Gly Ser Gly Lys Lys Gly Gln Asp Val Gly Ala Pro Asn 
        595                 600                 605             


Gly Ala Leu Ser Arg Leu Asp Gln Leu Ser Gly Ala Gln Leu Thr Ser 
    610                 615                 620                 


Ser Leu Pro Ser Pro Ser Pro Ala Ile Ala Lys Ser Gln Glu Gln Val 
625                 630                 635                 640 


His Leu Leu Arg Ser Thr Phe Ala Arg Thr Gln Trp Pro Thr Pro Gln 
                645                 650                 655     


Glu Tyr Asp Gln Leu Ala Ala Lys Thr Gly Leu Val Arg Thr Glu Ile 
            660                 665                 670         


Val Arg Trp Phe Lys Glu Asn Arg Cys Leu Leu Lys Thr Gly Thr Val 
        675                 680                 685             


Lys Trp Met Glu Gln Tyr Gln His Gln Pro Met Ala Asp Asp His Gly 
    690                 695                 700                 


Tyr Asp Ala Val Ala Arg Lys Ala Thr Lys Pro Met Ala Glu Ser Pro 
705                 710                 715                 720 


Lys Asn Gly Gly Asp Val Val Pro Gln Tyr Tyr Lys Asp Pro Lys Lys 
                725                 730                 735     


Leu Cys Glu Glu Asp Leu Glu Lys Leu Val Thr Arg Val Lys Val Gly 
            740                 745                 750         


Ser Glu Pro Ala Lys Asp Cys Leu Pro Ala Lys Pro Ser Glu Ala Thr 
        755                 760                 765             


Ser Asp Arg Ser Glu Gly Ser Ser Arg Asp Gly Gln Gly Ser Asp Glu 
    770                 775                 780                 


Asn Glu Glu Ser Ser Val Val Asp Tyr Val Glu Val Thr Val Gly Glu 
785                 790                 795                 800 


Glu Asp Ala Ile Ser Asp Arg Ser Asp Ser Trp Ser Gln Ala Ala Ala 
                805                 810                 815     


Glu Gly Val Ser Glu Leu Ala Glu Ser Asp Ser Asp Cys Val Pro Ala 
            820                 825                 830         


Glu Ala Gly Gln Ala 
        835         


<210>  550
<211>  4568
<212>  DNA
<213>  Homo sapiens

<400>  550
gtgagaacta ggagcctgtc ctccatgttt tataagtatt gacattacac agtgttaaca       60

atgcatccac agagcttggc tgaagaggaa ataaaaacag aacaggaggt ggtagagggc      120

atggatatct ctactcgctc caaagatcct ggctctgcag agagaacagc ccagaaaaga      180

aagttcccca gccctccaca ttcttccaat ggccactcgc cgcaggacac atcaacaagc      240

cccattaaaa agaaaaagaa acctggctta ctgaacagta acaataagga gcagtcagaa      300

ctaagacatg gtccgtttta ctatatgaag cagccactca ccacagaccc tgttgatgtt      360

gtaccgcagg atggacggaa tgatttctac tgctgggttt gtcaccggga aggccaagtc      420

ctttgctgtg agctctgtcc ccgggtttat cacgctaagt gtctgagact gacatcggaa      480

ccagaggggg actggttttg tcctgaatgt gagaaaatta cagtagcaga atgcatcgag      540

acccagagta aagccatgac aatgctcacc attgaacagt tatcctacct gctcaagttt      600

gccattcaga aaatgaaaca gccagggaca gatgcattcc agaagcccgt tccattggaa      660

cagcaccctg actatgcgga atacatcttc catccaatgg acctttgtac attggaaaag      720

aatgcgaaaa agaaaatgta tggctgcaca gaagccttcc tggctgatgc aaagtggatt      780

ttgcacaact gcatcattta taatggggga aatcacaaat tgacgcaaat agcgaaagta      840

gtcatcaaaa tctgtgaaca tgagatgaat gaaatcgaag tatgtccaga atgttatcta      900

gctgcttgcc aaaaacgaga taactggttt tgtgagcctt gtagcaatcc acatcctttg      960

gtctgggcca aactgaaggg gtttccattc tggcctgcaa aagctctaag ggataaagac     1020

gggcaggtcg atgcccgatt ctttggacaa catgacaggg cctgggttcc aataaataat     1080

tgctacctca tgtctaaaga aattcctttt tctgtgaaaa agactaagag catcttcaac     1140

agtgccatgc aagagatgga ggtttacgtg gagaacatcc gcaggaagtt tggggttttt     1200

aattactctc catttaggac accctacaca cccaacagcc agtatcaaat gctgctcgat     1260

cccaccaacc ccagcgccgg cactgccaag atagacaagc aggagaaggt caagctcaac     1320

tttgacatga cggcatcccc caagatcctg atgagcaagc ctgtgctgag tgggggcaca     1380

ggccgccgga tttccttgtc ggatatgccg cgctccccca tgagcacaaa ctcttctgtg     1440

cacacgggct ccgacgtgga gcaggatgct gagaagaagg ccacgtcgag ccacttcagt     1500

gcgagcgagg agtccatgga cttcctggat aagagcacag cttcaccagc ctccaccaag     1560

acgggacaag cagggagttt atccggcagc ccaaagccct tctctcctca actgtcagct     1620

cctatcacga cgaaaacgga caaaacctcc accaccggca gcatcctgaa tcttaacctg     1680

gatcgaagca aagctgagat ggatttgaag gagctgagcg agtcggtcca gcaacagtcc     1740

acccctgttc ctctcatctc tcccaagcgc cagattcgta gcaggttcca gctgaatctt     1800

gacaagacca tagagagttg caaagcacaa ttaggcataa atgaaatctc ggaagatgtc     1860

tatacggccg tagagcacag cgattcggag gattctgaga agtcagatag tagcgatagt     1920

gagtatatca gtgatgatga gcagaagtct aagaacgagc cagaagacac agaggacaaa     1980

gaaggttgtc agatggacaa agagccatct gctgttaaaa aaaagcccaa gcctacaaac     2040

ccagtggaga ttaaagagga gctgaaaagc acgtcaccag ccagcgagaa ggcagaccct     2100

ggagcagtca aggacaaggc cagccctgag cctgagaagg acttttccga aaaggcaaaa     2160

ccttcacctc accccataaa ggataaactg aagggaaaag atgagacgga ttccccaaca     2220

gtccatttgg gcctggactc tgattcagag agcgaacttg tcatagattt aggagaagac     2280

cattctgggc gggagggtcg aaaaaataag aaggaaccca aagaaccatc tcccaaacag     2340

gatgttgtag gtaaaactcc accatccacg acggtgggca gccattctcc cccggaaaca     2400

ccggtgctca cccgctcttc cgcccaaact tccgcggctg gcgccacagc caccaccagc     2460

acgtcctcca cggtcaccgt cacggccccg gcccccgccg ccacaggaag cccagtgaaa     2520

aagcagaggc cgcttttacc gaaggagact gccccggccg tgcagcgggt cgtgtggaac     2580

tcatcaactg tccagcagaa ggagatcaca cagagcccat ccacgtccac catcaccctg     2640

gtgaccagca cacagtcatc gcccctggtc accagctcgg ggtccatgag cacccttgtg     2700

tcctcagtca acgctgacct gcccatcgcc actgcctcag ctgatgtcgc cgctgatatt     2760

gccaagtaca ctagcaaaat gatggatgca ataaaaggaa caatgacaga aatatacaac     2820

gatctttcta aaaacactac tggaagcaca atagctgaga ttcgcaggct gaggatcgag     2880

atagagaagc tccagtggct gcaccagcaa gagctctccg aaatgaaaca caacttagag     2940

ctgaccatgg cggagatgcg gcagagcctg gagcaggagc gggaccggct catcgccgag     3000

gtgaagaagc agctggagtt ggagaagcag caggcggtgg atgagaccaa gaagaagcag     3060

tggtgcgcca actgcaagaa ggaggccatc ttttactgct gttggaacac tagctactgt     3120

gactacccct gccagcaagc ccactggcct gagcacatga agtcctgcac ccagtcagct     3180

actgctcctc agcaggaagc ggatgctgag gtgaacacag aaacactaaa taagtcctcc     3240

caggggagct cctcgagcac acaatcagca ccttcagaaa cggccagcgc ctccaaagag     3300

aaggagacgt cagctgagaa aagcaaggag agtggctcga cccttgacct ttctggctcc     3360

agagagacgc cctcctccat tctcttaggc tccaaccaag gctctgacca ttcccggagt     3420

aataaatcca gttggagcag cagtgatgag aagaggggat cgacacgttc cgatcacaac     3480

accagtacca gcacgaagag cctcctcccg aaagagtctc ggctggacac cttctgggac     3540

tagcagtgaa tcgggacaca aaccacccac cccattggga gaaaaaccca gacgccagga     3600

aaagaagaaa caacaaaggc aggagaacag ccactttcag acttgaaaat gacaaaaccc     3660

tcagttgagc ctgagccccc ggcgcggggg ctgctacact acaggacacc cagcatcggc     3720

tttgactgca gactgttcac ccacacgagc cctgtgcttt tggtgtaaat aatgtacaat     3780

ttgtggatgt cattgaatct agaggacttt ccccttttta tatttgtatt aactttaact     3840

tattaaaaaa aaaaaaagaa aaagaaaaac gatttaaaaa aaaaaaaaaa agcaaccaac     3900

cccaacaaca aaaaagaatg ttttggtatt ggagaaggga tggtcagtta gcctgtctgt     3960

cacacgacgg aatggatact gggcccgggg accactttca tactcacgtc ctcatccttg     4020

gatacccagg ggagggcgaa ccgttttcgc tcgtgtgtct gtacgcagca tgttgggatc     4080

gggagtttcg gcacagacta tcccatcaag ccgttggctc ctttcagcta ctacgttacc     4140

acgttcctaa aacgcaagct ctccggacca gacggacaca gggagaagct agtttctttc     4200

atgtgattga aatgatgact ctactcctaa aagggaaaaa acaatatcct tgtttacaga     4260

agagaaacaa acaagcccca ctcagctcag tcacaggaga gaacacagaa agtcttagga     4320

tcatgaactc tgaaaaaaag agaaacctta tctttgcttt gtggttcctt taaacacact     4380

cacacacact tggtcagaga tgctgtgctt cttggaagca aggactcaaa ggcaaggtgc     4440

acgcagagga cgtttgagtc tgggatgaag catgtacgta ttatttatat gatggaattt     4500

cacgttttta tgtaagcatg aaacacaggc agtatgagag aaagcaaggc ccgtcatgct     4560

gtccgtac                                                              4568


<210>  551
<211>  1160
<212>  PRT
<213>  Homo sapiens

<400>  551

Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu 
1               5                   10                  15      


Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser 
            20                  25                  30          


Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser 
        35                  40                  45              


Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys 
    50                  55                  60                  


Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu 
65                  70                  75                  80  


Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp 
                85                  90                  95      


Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp 
            100                 105                 110         


Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg 
        115                 120                 125             


Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp 
    130                 135                 140                 


Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu 
145                 150                 155                 160 


Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr 
                165                 170                 175     


Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr 
        195                 200                 205             


Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys 
    210                 215                 220                 


Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile 
225                 230                 235                 240 


Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln 
                245                 250                 255     


Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile 
            260                 265                 270         


Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn 
        275                 280                 285             


Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys 
    290                 295                 300                 


Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp 
305                 310                 315                 320 


Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val 
                325                 330                 335     


Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val 
            340                 345                 350         


Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val 
        355                 360                 365             


Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro 
    370                 375                 380                 


Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp 
385                 390                 395                 400 


Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys 
                405                 410                 415     


Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser 
            420                 425                 430         


Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp 
        435                 440                 445             


Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser 
    450                 455                 460                 


Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser 
465                 470                 475                 480 


Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro 
                485                 490                 495     


Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys 
            500                 505                 510         


Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys 
        515                 520                 525             


Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys 
    530                 535                 540                 


Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser 
545                 550                 555                 560 


Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe 
                565                 570                 575     


Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly 
            580                 585                 590         


Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp 
        595                 600                 605             


Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser 
    610                 615                 620                 


Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys 
625                 630                 635                 640 


Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro 
                645                 650                 655     


Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser 
            660                 665                 670         


Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser 
        675                 680                 685             


Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His 
    690                 695                 700                 


Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr 
705                 710                 715                 720 


Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp 
                725                 730                 735     


Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu 
            740                 745                 750         


Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro 
        755                 760                 765             


Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr 
    770                 775                 780                 


Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser 
785                 790                 795                 800 


Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly 
                805                 810                 815     


Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro 
            820                 825                 830         


Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu 
        835                 840                 845             


Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr 
    850                 855                 860                 


Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val 
865                 870                 875                 880 


Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val 
                885                 890                 895     


Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys 
            900                 905                 910         


Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly 
        915                 920                 925             


Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu 
    930                 935                 940                 


Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu 
945                 950                 955                 960 


Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg 
                965                 970                 975     


Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala 
            980                 985                 990         


Val Asp Glu Thr Lys Lys Lys Gln  Trp Cys Ala Asn Cys  Lys Lys Glu 
        995                 1000                 1005             


Ala Ile  Phe Tyr Cys Cys Trp  Asn Thr Ser Tyr Cys  Asp Tyr Pro 
    1010                 1015                 1020             


Cys Gln  Gln Ala His Trp Pro  Glu His Met Lys Ser  Cys Thr Gln 
    1025                 1030                 1035             


Ser Ala  Thr Ala Pro Gln Gln  Glu Ala Asp Ala Glu  Val Asn Thr 
    1040                 1045                 1050             


Glu Thr  Leu Asn Lys Ser Ser  Gln Gly Ser Ser Ser  Ser Thr Gln 
    1055                 1060                 1065             


Ser Ala  Pro Ser Glu Thr Ala  Ser Ala Ser Lys Glu  Lys Glu Thr 
    1070                 1075                 1080             


Ser Ala  Glu Lys Ser Lys Glu  Ser Gly Ser Thr Leu  Asp Leu Ser 
    1085                 1090                 1095             


Gly Ser  Arg Glu Thr Pro Ser  Ser Ile Leu Leu Gly  Ser Asn Gln 
    1100                 1105                 1110             


Gly Ser  Asp His Ser Arg Ser  Asn Lys Ser Ser Trp  Ser Ser Ser 
    1115                 1120                 1125             


Asp Glu  Lys Arg Gly Ser Thr  Arg Ser Asp His Asn  Thr Ser Thr 
    1130                 1135                 1140             


Ser Thr  Lys Ser Leu Leu Pro  Lys Glu Ser Arg Leu  Asp Thr Phe 
    1145                 1150                 1155             


Trp Asp  
    1160 


<210>  552
<211>  4652
<212>  DNA
<213>  Homo sapiens

<400>  552
gtgagaacta ggagcctgtc ctccatgttt tataagtatt gacattacac agtgttaaca       60

atgcatccac agagcttggc tgaagaggaa ataaaaacag aacaggaggt ggtagagggc      120

atggatatct ctactcgctc caaagatcct ggctctgcag agagaacagc ccagaaaaga      180

aagttcccca gccctccaca ttcttccaat ggccactcgc cgcaggacac atcaacaagc      240

cccattaaaa agaaaaagaa acctggctta ctgaacagta acaataagga gcagtcagaa      300

ctaagacatg gtccgtttta ctatatgaag cagccactca ccacagaccc tgttgatgtt      360

gtaccgcagg atggacggaa tgatttctac tgctgggttt gtcaccggga aggccaagtc      420

ctttgctgtg agctctgtcc ccgggtttat cacgctaagt gtctgagact gacatcggaa      480

ccagaggggg actggttttg tcctgaatgt gagaaaatta cagtagcaga atgcatcgag      540

acccagagta aagccatgac aatgctcacc attgaacagt tatcctacct gctcaagttt      600

gccattcaga aaatgaaaca gccagggaca gatgcattcc agaagcccgt tccattggaa      660

cagcaccctg actatgcgga atacatcttc catccaatgg acctttgtac attggaaaag      720

aatgcgaaaa agaaaatgta tggctgcaca gaagccttcc tggctgatgc aaagtggatt      780

ttgcacaact gcatcattta taatggggga aatcacaaat tgacgcaaat agcgaaagta      840

gtcatcaaaa tctgtgaaca tgagatgaat gaaatcgaag tatgtccaga atgttatcta      900

gctgcttgcc aaaaacgaga taactggttt tgtgagcctt gtagcaatcc acatcctttg      960

gtctgggcca aactgaaggg gtttccattc tggcctgcaa aagctctaag ggataaagac     1020

gggcaggtcg atgcccgatt ctttggacaa catgacaggg cctgggttcc aataaataat     1080

tgctacctca tgtctaaaga aattcctttt tctgtgaaaa agactaagag catcttcaac     1140

agtgccatgc aagagatgga ggtttacgtg gagaacatcc gcaggaagtt tggggttttt     1200

aattactctc catttaggac accctacaca cccaacagcc agtatcaaat gctgctcgat     1260

cccaccaacc ccagcgccgg cactgccaag atagacaagc aggagaaggt caagctcaac     1320

tttgacatga cggcatcccc caagatcctg atgagcaagc ctgtgctgag tgggggcaca     1380

ggccgccgga tttccttgtc ggatatgccg cgctccccca tgagcacaaa ctcttctgtg     1440

cacacgggct ccgacgtgga gcaggatgct gagaagaagg ccacgtcgag ccacttcagt     1500

gcgagcgagg agtccatgga cttcctggat aagagcacag cttcaccagc ctccaccaag     1560

acgggacaag cagggagttt atccggcagc ccaaagccct tctctcctca actgtcagct     1620

cctatcacga cgaaaacgga caaaacctcc accaccggca gcatcctgaa tcttaacctg     1680

gatcgaagca aagctgagat ggatttgaag gagctgagcg agtcggtcca gcaacagtcc     1740

acccctgttc ctctcatctc tcccaagcgc cagattcgta gcaggttcca gctgaatctt     1800

gacaagacca tagagagttg caaagcacaa ttaggcataa atgaaatctc ggaagatgtc     1860

tatacggccg tagagcacag cgattcggag gattctgaga agtcagatag tagcgatagt     1920

gagtatatca gtgatgatga gcagaagtct aagaacgagc cagaagacac agaggacaaa     1980

gaaggttgtc agatggacaa agagccatct gctgttaaaa aaaagcccaa gcctacaaac     2040

ccagtggaga ttaaagagga gctgaaaagc acgtcaccag ccagcgagaa ggcagaccct     2100

ggagcagtca aggacaaggc cagccctgag cctgagaagg acttttccga aaaggcaaaa     2160

ccttcacctc accccataaa ggataaactg aagggaaaag atgagacgga ttccccaaca     2220

gtccatttgg gcctggactc tgattcagag agcgaacttg tcatagattt aggagaagac     2280

cattctgggc gggagggtcg aaaaaataag aaggaaccca aagaaccatc tcccaaacag     2340

gatgttgtag gtaaaactcc accatccacg acggtgggca gccattctcc cccggaaaca     2400

ccggtgctca cccgctcttc cgcccaaact tccgcggctg gcgccacagc caccaccagc     2460

acgtcctcca cggtcaccgt cacggccccg gcccccgccg ccacaggaag cccagtgaaa     2520

aagcagaggc cgcttttacc gaaggagact gccccggccg tgcagcgggt cgtgtggaac     2580

tcatcaactg tccagcagaa ggagatcaca cagagcccat ccacgtccac catcaccctg     2640

gtgaccagca cacagtcatc gcccctggtc accagctcgg ggtccatgag cacccttgtg     2700

tcctcagtca acgctgacct gcccatcgcc actgcctcag ctgatgtcgc cgctgatatt     2760

gccaagtaca ctagcaaaat gatggatgca ataaaaggaa caatgacaga aatatacaac     2820

gatctttcta aaaacactac tggaagcaca atagctgaga ttcgcaggct gaggatcgag     2880

atagagaagc tccagtggct gcaccagcaa gagctctccg aaatgaaaca caacttagag     2940

ctgaccatgg cggagatgcg gcagagcctg gagcaggagc gggaccggct catcgccgag     3000

gtgaagaagc agctggagtt ggagaagcag caggcggtgg atgagaccaa gaagaagcag     3060

tggtgcgcca actgcaagaa ggaggccatc ttttactgct gttggaacac tagctactgt     3120

gactacccct gccagcaagc ccactggcct gagcacatga agtcctgcac ccagtcagct     3180

actgctcctc agcaggaagc ggatgctgag gtgaacacag aaacactaaa taagtcctcc     3240

caggggagct cctcgagcac acaatcagca ccttcagaaa cggccagcgc ctccaaagag     3300

aaggagacgt cagctgagaa aagcaaggag agtggctcga cccttgacct ttctggctcc     3360

agagagacgc cctcctccat tctcttaggc tccaaccaag gctctgttag caaaaggtgt     3420

gacaagcaac ctgcctatgc cccaaccacc acagaccacc agccgcaccc caactacccc     3480

gcccagaagt accattcccg gagtaataaa tccagttgga gcagcagtga tgagaagagg     3540

ggatcgacac gttccgatca caacaccagt accagcacga agagcctcct cccgaaagag     3600

tctcggctgg acaccttctg ggactagcag tgaatcggga cacaaaccac ccaccccatt     3660

gggagaaaaa cccagacgcc aggaaaagaa gaaacaacaa aggcaggaga acagccactt     3720

tcagacttga aaatgacaaa accctcagtt gagcctgagc ccccggcgcg ggggctgcta     3780

cactacagga cacccagcat cggctttgac tgcagactgt tcacccacac gagccctgtg     3840

cttttggtgt aaataatgta caatttgtgg atgtcattga atctagagga ctttcccctt     3900

tttatatttg tattaacttt aacttattaa aaaaaaaaaa agaaaaagaa aaacgattta     3960

aaaaaaaaaa aaaaagcaac caaccccaac aacaaaaaag aatgttttgg tattggagaa     4020

gggatggtca gttagcctgt ctgtcacacg acggaatgga tactgggccc ggggaccact     4080

ttcatactca cgtcctcatc cttggatacc caggggaggg cgaaccgttt tcgctcgtgt     4140

gtctgtacgc agcatgttgg gatcgggagt ttcggcacag actatcccat caagccgttg     4200

gctcctttca gctactacgt taccacgttc ctaaaacgca agctctccgg accagacgga     4260

cacagggaga agctagtttc tttcatgtga ttgaaatgat gactctactc ctaaaaggga     4320

aaaaacaata tccttgttta cagaagagaa acaaacaagc cccactcagc tcagtcacag     4380

gagagaacac agaaagtctt aggatcatga actctgaaaa aaagagaaac cttatctttg     4440

ctttgtggtt cctttaaaca cactcacaca cacttggtca gagatgctgt gcttcttgga     4500

agcaaggact caaaggcaag gtgcacgcag aggacgtttg agtctgggat gaagcatgta     4560

cgtattattt atatgatgga atttcacgtt tttatgtaag catgaaacac aggcagtatg     4620

agagaaagca aggcccgtca tgctgtccgt ac                                   4652


<210>  553
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  553

Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu 
1               5                   10                  15      


Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser 
            20                  25                  30          


Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser 
        35                  40                  45              


Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys 
    50                  55                  60                  


Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu 
65                  70                  75                  80  


Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp 
                85                  90                  95      


Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp 
            100                 105                 110         


Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg 
        115                 120                 125             


Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp 
    130                 135                 140                 


Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu 
145                 150                 155                 160 


Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr 
                165                 170                 175     


Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr 
        195                 200                 205             


Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys 
    210                 215                 220                 


Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile 
225                 230                 235                 240 


Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln 
                245                 250                 255     


Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile 
            260                 265                 270         


Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn 
        275                 280                 285             


Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys 
    290                 295                 300                 


Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp 
305                 310                 315                 320 


Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val 
                325                 330                 335     


Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val 
            340                 345                 350         


Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val 
        355                 360                 365             


Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro 
    370                 375                 380                 


Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp 
385                 390                 395                 400 


Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys 
                405                 410                 415     


Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser 
            420                 425                 430         


Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp 
        435                 440                 445             


Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser 
    450                 455                 460                 


Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser 
465                 470                 475                 480 


Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro 
                485                 490                 495     


Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys 
            500                 505                 510         


Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys 
        515                 520                 525             


Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys 
    530                 535                 540                 


Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser 
545                 550                 555                 560 


Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe 
                565                 570                 575     


Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly 
            580                 585                 590         


Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp 
        595                 600                 605             


Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser 
    610                 615                 620                 


Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys 
625                 630                 635                 640 


Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro 
                645                 650                 655     


Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser 
            660                 665                 670         


Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser 
        675                 680                 685             


Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His 
    690                 695                 700                 


Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr 
705                 710                 715                 720 


Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp 
                725                 730                 735     


Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu 
            740                 745                 750         


Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro 
        755                 760                 765             


Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr 
    770                 775                 780                 


Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser 
785                 790                 795                 800 


Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly 
                805                 810                 815     


Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro 
            820                 825                 830         


Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu 
        835                 840                 845             


Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr 
    850                 855                 860                 


Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val 
865                 870                 875                 880 


Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val 
                885                 890                 895     


Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys 
            900                 905                 910         


Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly 
        915                 920                 925             


Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu 
    930                 935                 940                 


Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu 
945                 950                 955                 960 


Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg 
                965                 970                 975     


Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala 
            980                 985                 990         


Val Asp Glu Thr Lys Lys Lys Gln  Trp Cys Ala Asn Cys  Lys Lys Glu 
        995                 1000                 1005             


Ala Ile  Phe Tyr Cys Cys Trp  Asn Thr Ser Tyr Cys  Asp Tyr Pro 
    1010                 1015                 1020             


Cys Gln  Gln Ala His Trp Pro  Glu His Met Lys Ser  Cys Thr Gln 
    1025                 1030                 1035             


Ser Ala  Thr Ala Pro Gln Gln  Glu Ala Asp Ala Glu  Val Asn Thr 
    1040                 1045                 1050             


Glu Thr  Leu Asn Lys Ser Ser  Gln Gly Ser Ser Ser  Ser Thr Gln 
    1055                 1060                 1065             


Ser Ala  Pro Ser Glu Thr Ala  Ser Ala Ser Lys Glu  Lys Glu Thr 
    1070                 1075                 1080             


Ser Ala  Glu Lys Ser Lys Glu  Ser Gly Ser Thr Leu  Asp Leu Ser 
    1085                 1090                 1095             


Gly Ser  Arg Glu Thr Pro Ser  Ser Ile Leu Leu Gly  Ser Asn Gln 
    1100                 1105                 1110             


Gly Ser  Val Ser Lys Arg Cys  Asp Lys Gln Pro Ala  Tyr Ala Pro 
    1115                 1120                 1125             


Thr Thr  Thr Asp His Gln Pro  His Pro Asn Tyr Pro  Ala Gln Lys 
    1130                 1135                 1140             


Tyr His  Ser Arg Ser Asn Lys  Ser Ser Trp Ser Ser  Ser Asp Glu 
    1145                 1150                 1155             


Lys Arg  Gly Ser Thr Arg Ser  Asp His Asn Thr Ser  Thr Ser Thr 
    1160                 1165                 1170             


Lys Ser  Leu Leu Pro Lys Glu  Ser Arg Leu Asp Thr  Phe Trp Asp 
    1175                 1180                 1185             


<210>  554
<211>  4493
<212>  DNA
<213>  Homo sapiens

<400>  554
gtgagaacta ggagcctgtc ctccatgttt tataagtatt gacattacac agtgttaaca       60

atgcatccac agagcttggc tgaagaggaa ataaaaacag aacaggaggt ggtagagggc      120

atggatatct ctactcgctc caaagatcct ggctctgcag agagaacagc ccagaaaaga      180

aagttcccca gccctccaca ttcttccaat ggccactcgc cgcaggacac atcaacaagc      240

cccattaaaa agaaaaagaa acctggctta ctgaacagta acaataagga gcaggatgga      300

cggaatgatt tctactgctg ggtttgtcac cgggaaggcc aagtcctttg ctgtgagctc      360

tgtccccggg tttatcacgc taagtgtctg agactgacat cggaaccaga gggggactgg      420

ttttgtcctg aatgtgagaa aattacagta gcagaatgca tcgagaccca gagtaaagcc      480

atgacaatgc tcaccattga acagttatcc tacctgctca agtttgccat tcagaaaatg      540

aaacagccag ggacagatgc attccagaag cccgttccat tggaacagca ccctgactat      600

gcggaataca tcttccatcc aatggacctt tgtacattgg aaaagaatgc gaaaaagaaa      660

atgtatggct gcacagaagc cttcctggct gatgcaaagt ggattttgca caactgcatc      720

atttataatg ggggaaatca caaattgacg caaatagcga aagtagtcat caaaatctgt      780

gaacatgaga tgaatgaaat cgaagtatgt ccagaatgtt atctagctgc ttgccaaaaa      840

cgagataact ggttttgtga gccttgtagc aatccacatc ctttggtctg ggccaaactg      900

aaggggtttc cattctggcc tgcaaaagct ctaagggata aagacgggca ggtcgatgcc      960

cgattctttg gacaacatga cagggcctgg gttccaataa ataattgcta cctcatgtct     1020

aaagaaattc ctttttctgt gaaaaagact aagagcatct tcaacagtgc catgcaagag     1080

atggaggttt acgtggagaa catccgcagg aagtttgggg tttttaatta ctctccattt     1140

aggacaccct acacacccaa cagccagtat caaatgctgc tcgatcccac caaccccagc     1200

gccggcactg ccaagataga caagcaggag aaggtcaagc tcaactttga catgacggca     1260

tcccccaaga tcctgatgag caagcctgtg ctgagtgggg gcacaggccg ccggatttcc     1320

ttgtcggata tgccgcgctc ccccatgagc acaaactctt ctgtgcacac gggctccgac     1380

gtggagcagg atgctgagaa gaaggccacg tcgagccact tcagtgcgag cgaggagtcc     1440

atggacttcc tggataagag cacagcttca ccagcctcca ccaagacggg acaagcaggg     1500

agtttatccg gcagcccaaa gcccttctct cctcaactgt cagctcctat cacgacgaaa     1560

acggacaaaa cctccaccac cggcagcatc ctgaatctta acctggatcg aagcaaagct     1620

gagatggatt tgaaggagct gagcgagtcg gtccagcaac agtccacccc tgttcctctc     1680

atctctccca agcgccagat tcgtagcagg ttccagctga atcttgacaa gaccatagag     1740

agttgcaaag cacaattagg cataaatgaa atctcggaag atgtctatac ggccgtagag     1800

cacagcgatt cggaggattc tgagaagtca gatagtagcg atagtgagta tatcagtgat     1860

gatgagcaga agtctaagaa cgagccagaa gacacagagg acaaagaagg ttgtcagatg     1920

gacaaagagc catctgctgt taaaaaaaag cccaagccta caaacccagt ggagattaaa     1980

gaggagctga aaagcacgtc accagccagc gagaaggcag accctggagc agtcaaggac     2040

aaggccagcc ctgagcctga gaaggacttt tccgaaaagg caaaaccttc acctcacccc     2100

ataaaggata aactgaaggg aaaagatgag acggattccc caacagtcca tttgggcctg     2160

gactctgatt cagagagcga acttgtcata gatttaggag aagaccattc tgggcgggag     2220

ggtcgaaaaa ataagaagga acccaaagaa ccatctccca aacaggatgt tgtaggtaaa     2280

actccaccat ccacgacggt gggcagccat tctcccccgg aaacaccggt gctcacccgc     2340

tcttccgccc aaacttccgc ggctggcgcc acagccacca ccagcacgtc ctccacggtc     2400

accgtcacgg ccccggcccc cgccgccaca ggaagcccag tgaaaaagca gaggccgctt     2460

ttaccgaagg agactgcccc ggccgtgcag cgggtcgtgt ggaactcatc aactgtccag     2520

cagaaggaga tcacacagag cccatccacg tccaccatca ccctggtgac cagcacacag     2580

tcatcgcccc tggtcaccag ctcggggtcc atgagcaccc ttgtgtcctc agtcaacgct     2640

gacctgccca tcgccactgc ctcagctgat gtcgccgctg atattgccaa gtacactagc     2700

aaaatgatgg atgcaataaa aggaacaatg acagaaatat acaacgatct ttctaaaaac     2760

actactggaa gcacaatagc tgagattcgc aggctgagga tcgagataga gaagctccag     2820

tggctgcacc agcaagagct ctccgaaatg aaacacaact tagagctgac catggcggag     2880

atgcggcaga gcctggagca ggagcgggac cggctcatcg ccgaggtgaa gaagcagctg     2940

gagttggaga agcagcaggc ggtggatgag accaagaaga agcagtggtg cgccaactgc     3000

aagaaggagg ccatctttta ctgctgttgg aacactagct actgtgacta cccctgccag     3060

caagcccact ggcctgagca catgaagtcc tgcacccagt cagctactgc tcctcagcag     3120

gaagcggatg ctgaggtgaa cacagaaaca ctaaataagt cctcccaggg gagctcctcg     3180

agcacacaat cagcaccttc agaaacggcc agcgcctcca aagagaagga gacgtcagct     3240

gagaaaagca aggagagtgg ctcgaccctt gacctttctg gctccagaga gacgccctcc     3300

tccattctct taggctccaa ccaaggctct gaccattccc ggagtaataa atccagttgg     3360

agcagcagtg atgagaagag gggatcgaca cgttccgatc acaacaccag taccagcacg     3420

aagagcctcc tcccgaaaga gtctcggctg gacaccttct gggactagca gtgaatcggg     3480

acacaaacca cccaccccat tgggagaaaa acccagacgc caggaaaaga agaaacaaca     3540

aaggcaggag aacagccact ttcagacttg aaaatgacaa aaccctcagt tgagcctgag     3600

cccccggcgc gggggctgct acactacagg acacccagca tcggctttga ctgcagactg     3660

ttcacccaca cgagccctgt gcttttggtg taaataatgt acaatttgtg gatgtcattg     3720

aatctagagg actttcccct ttttatattt gtattaactt taacttatta aaaaaaaaaa     3780

aagaaaaaga aaaacgattt aaaaaaaaaa aaaaaagcaa ccaaccccaa caacaaaaaa     3840

gaatgttttg gtattggaga agggatggtc agttagcctg tctgtcacac gacggaatgg     3900

atactgggcc cggggaccac tttcatactc acgtcctcat ccttggatac ccaggggagg     3960

gcgaaccgtt ttcgctcgtg tgtctgtacg cagcatgttg ggatcgggag tttcggcaca     4020

gactatccca tcaagccgtt ggctcctttc agctactacg ttaccacgtt cctaaaacgc     4080

aagctctccg gaccagacgg acacagggag aagctagttt ctttcatgtg attgaaatga     4140

tgactctact cctaaaaggg aaaaaacaat atccttgttt acagaagaga aacaaacaag     4200

ccccactcag ctcagtcaca ggagagaaca cagaaagtct taggatcatg aactctgaaa     4260

aaaagagaaa ccttatcttt gctttgtggt tcctttaaac acactcacac acacttggtc     4320

agagatgctg tgcttcttgg aagcaaggac tcaaaggcaa ggtgcacgca gaggacgttt     4380

gagtctggga tgaagcatgt acgtattatt tatatgatgg aatttcacgt ttttatgtaa     4440

gcatgaaaca caggcagtat gagagaaagc aaggcccgtc atgctgtccg tac            4493


<210>  555
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  555

Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu 
1               5                   10                  15      


Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser 
            20                  25                  30          


Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser 
        35                  40                  45              


Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys 
    50                  55                  60                  


Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly 
65                  70                  75                  80  


Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg Glu Gly Gln Val Leu 
                85                  90                  95      


Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala Lys Cys Leu Arg Leu 
            100                 105                 110         


Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile 
        115                 120                 125             


Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys Ala Met Thr Met Leu 
    130                 135                 140                 


Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met 
145                 150                 155                 160 


Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val Pro Leu Glu Gln 
                165                 170                 175     


His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met Asp Leu Cys Thr 
            180                 185                 190         


Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe 
        195                 200                 205             


Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile Ile Tyr Asn Gly 
    210                 215                 220                 


Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val Val Ile Lys Ile Cys 
225                 230                 235                 240 


Glu His Glu Met Asn Glu Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala 
                245                 250                 255     


Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro 
            260                 265                 270         


His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala 
        275                 280                 285             


Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala Arg Phe Phe Gly 
    290                 295                 300                 


Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys Tyr Leu Met Ser 
305                 310                 315                 320 


Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser Ile Phe Asn Ser 
                325                 330                 335     


Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile Arg Arg Lys Phe 
            340                 345                 350         


Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser 
        355                 360                 365             


Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala 
    370                 375                 380                 


Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala 
385                 390                 395                 400 


Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly 
                405                 410                 415     


Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn 
            420                 425                 430         


Ser Ser Val His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys 
        435                 440                 445             


Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu 
    450                 455                 460                 


Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly 
465                 470                 475                 480 


Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro 
                485                 490                 495     


Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn 
            500                 505                 510         


Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser 
        515                 520                 525             


Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys 
    530                 535                 540                 


Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu 
545                 550                 555                 560 


Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr 
                565                 570                 575     


Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser 
            580                 585                 590         


Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu 
        595                 600                 605             


Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro 
    610                 615                 620                 


Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys 
625                 630                 635                 640 


Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly 
                645                 650                 655     


Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu 
            660                 665                 670         


Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys 
        675                 680                 685             


Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser 
    690                 695                 700                 


Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu 
705                 710                 715                 720 


Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp 
                725                 730                 735     


Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro 
            740                 745                 750         


Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala 
        755                 760                 765             


Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala 
    770                 775                 780                 


Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu 
785                 790                 795                 800 


Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg Val Val Trp Asn Ser 
                805                 810                 815     


Ser Thr Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr 
            820                 825                 830         


Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser 
        835                 840                 845             


Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp Leu Pro Ile 
    850                 855                 860                 


Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser 
865                 870                 875                 880 


Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp 
                885                 890                 895     


Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu 
            900                 905                 910         


Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser 
        915                 920                 925             


Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser 
    930                 935                 940                 


Leu Glu Gln Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu 
945                 950                 955                 960 


Glu Leu Glu Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp 
                965                 970                 975     


Cys Ala Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr 
            980                 985                 990         


Ser Tyr Cys Asp Tyr Pro Cys Gln  Gln Ala His Trp Pro  Glu His Met 
        995                 1000                 1005             


Lys Ser  Cys Thr Gln Ser Ala  Thr Ala Pro Gln Gln  Glu Ala Asp 
    1010                 1015                 1020             


Ala Glu  Val Asn Thr Glu Thr  Leu Asn Lys Ser Ser  Gln Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Thr Gln Ser Ala  Pro Ser Glu Thr Ala  Ser Ala Ser 
    1040                 1045                 1050             


Lys Glu  Lys Glu Thr Ser Ala  Glu Lys Ser Lys Glu  Ser Gly Ser 
    1055                 1060                 1065             


Thr Leu  Asp Leu Ser Gly Ser  Arg Glu Thr Pro Ser  Ser Ile Leu 
    1070                 1075                 1080             


Leu Gly  Ser Asn Gln Gly Ser  Asp His Ser Arg Ser  Asn Lys Ser 
    1085                 1090                 1095             


Ser Trp  Ser Ser Ser Asp Glu  Lys Arg Gly Ser Thr  Arg Ser Asp 
    1100                 1105                 1110             


His Asn  Thr Ser Thr Ser Thr  Lys Ser Leu Leu Pro  Lys Glu Ser 
    1115                 1120                 1125             


Arg Leu  Asp Thr Phe Trp Asp  
    1130                 1135 


<210>  556
<211>  2955
<212>  DNA
<213>  Homo sapiens

<400>  556
gggcgggcct cagacacact atgcgggttg cggggcctgg gggccggacg gctgtttcct       60

gtcctggtgc atggtggtcg gacgaaggaa ttgttggaaa attttctcgg aggtagaaga      120

tgttgttagc ccaaataaat cgagattctc agggaatgac agagtttcct ggaggaggga      180

tggaggcgca acatgttacg ctgtgcttga cagaggcagt caccgtggca gatggtgaca      240

acttagaaaa tatggaaggc gtaagcttgc aagcagtaac acttgcagat ggttctactg      300

cttacataca acacaattct aaagatgcaa aactcataga tggccaggtc attcagttgg      360

aagatggttc tgcggcctat gttcaacatg tacccatacc taaaagtaca ggggacagtt      420

tgcgtctaga ggatggtcaa gcagtacagt tagaagatgg taccacagca tttattcacc      480

acacctccaa agatagttat gaccagagtg cattacaggc ggttcagctg gaagatggta      540

ccacagctta tatccaccat gcagtgcaag tcccgcagtc tgacaccatc ttggcaattc      600

aggctgatgg gacagtggca ggtctgcaca ctggggatgc tacaattgac cctgacacca      660

tcagtgcttt ggaacagtat gcagcaaagg tgtccattga tggaagtgaa agtgtagcag      720

gtactggaat gattggagaa aatgagcaag agaaaaaaat gcagattgtt ttacaaggac      780

atgctacaag agtaactgct aaatctcaac agagtggaga gaaggcattt cgatgtgaat      840

atgatggatg tggaaaatta tatacaacag ctcatcatct caaggtccat gagaggtcac      900

acacaggaga tcggccttat cagtgtgagc atgcaggctg tgggaaggca tttgcaacag      960

gttatggatt aaaaagtcac gtcagaactc atacaggaga aaagccatat cggtgttcgg     1020

aagataattg tactaaatct ttcaaaactt caggagatct acagaaacac atcagaactc     1080

atacaggaga aaggcccttt aagtgtccct tcgaaggctg cggtcggtcc tttacaacat     1140

caaatatcag aaaagtgcac gttaggacac acacaggaga aagaccttat tactgcacag     1200

agccaggatg tgggagggca tttgccagtg caacaaatta taaaaaccat gtgaggatac     1260

acacaggaga aaagccatat gtttgtacag ttcctgggtg tgacaaaagg tttacagaat     1320

attccagttt gtacaaacat catgttgtcc acactcattc caaaccttac aactgtaacc     1380

actgtgggaa gacatacaag cagatctcca cgctggccat gcacaaacgg acagcccaca     1440

acgacactga gcccatcgag gaggagcagg aagccttctt tgagccgccc ccaggtcaag     1500

gtgaagatgt tcttaaaggg tcccagatta cgtatgttac aggtgtagaa ggggacgacg     1560

ttgtttctac acaagtagcc acagtaaccc aatctggact gagtcaacaa gttacactca     1620

tatcccagga tgggactcag catgtcaaca tatctcaagc tgacatgcag gccattggca     1680

acaccatcac aatggtaacg caggatggca cgcccatcac agtccccgcc catgatgcag     1740

tcatctcctc agcaggaacg cactctgttg ctatggttac tgctgagggt acagaagggg     1800

aacaggttgc aattgtagct caagacttgg cagcattcca tactgcctca tcagaaatgg     1860

ggcaccagca gcatagccat cacttagtaa ccacagaaac cagacctctg accttagtag     1920

caacatccaa tggcacccag attgcagttc agcttggaga acagccatct ctggaagaag     1980

ccatcagaat agcgtctaga atccaacaag gagaaacgcc agggttggat gattaatcct     2040

cagaacaatg gagcaataaa gcagaaggag tctttcatct tctggcagca gaaatccatg     2100

aagcccgggc ccaggaaaat tagaagtttt ccattcctga tacactgtac acatttttat     2160

gcgagagtgg agaacatttt attcttgaca cttttgtgta tataaccctt ggaatagatt     2220

ctcagagtga ttcattgtgt acaaggaagt atgaaattag ggcaatacag taaattttca     2280

tgttactctt ttatcagatc acaaactcct agagtctaca tgcaagacta gtaaagtctt     2340

atggagtctt atgatggatt tttaacttcc cgtggaaaaa aaaataaagg ctgtatctaa     2400

aatatcaaag gttctatatg tcacacaatc gtaattccaa aagccattat ggataataaa     2460

gggtgtaaag ccttcagata tttccccagt tagtagagtg tctgcggttt ttgttctact     2520

atatgcttgt ccatttttat ttgtatctca tggtttgcag actgtttgaa taatttatag     2580

tttcccatcc ctgttaaaaa ccagctcttc aagctgaaat gctaattata ttggcattac     2640

attgaattat gtacaaaatt ataaaatttg gttatttaaa attaaaaagt taaatccagt     2700

ggttttgtta aagattttgc ttagtattca atttttatta ctgtttttta aaaataatga     2760

atcatcaaag tttaaccaca ggctggtgcc cgggataaca gtactgtaat tggaaatggc     2820

tttactctga aaattaggtt agtgggttgg tgtaaattat ttatttttgc ttatgtactt     2880

ttgttttaaa gcttatttac cccaaagttt attattaatt ttgaatacag caatttttaa     2940

aatgttaaaa aaaaa                                                      2955


<210>  557
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  557

Met Leu Leu Ala Gln Ile Asn Arg Asp Ser Gln Gly Met Thr Glu Phe 
1               5                   10                  15      


Pro Gly Gly Gly Met Glu Ala Gln His Val Thr Leu Cys Leu Thr Glu 
            20                  25                  30          


Ala Val Thr Val Ala Asp Gly Asp Asn Leu Glu Asn Met Glu Gly Val 
        35                  40                  45              


Ser Leu Gln Ala Val Thr Leu Ala Asp Gly Ser Thr Ala Tyr Ile Gln 
    50                  55                  60                  


His Asn Ser Lys Asp Ala Lys Leu Ile Asp Gly Gln Val Ile Gln Leu 
65                  70                  75                  80  


Glu Asp Gly Ser Ala Ala Tyr Val Gln His Val Pro Ile Pro Lys Ser 
                85                  90                  95      


Thr Gly Asp Ser Leu Arg Leu Glu Asp Gly Gln Ala Val Gln Leu Glu 
            100                 105                 110         


Asp Gly Thr Thr Ala Phe Ile His His Thr Ser Lys Asp Ser Tyr Asp 
        115                 120                 125             


Gln Ser Ala Leu Gln Ala Val Gln Leu Glu Asp Gly Thr Thr Ala Tyr 
    130                 135                 140                 


Ile His His Ala Val Gln Val Pro Gln Ser Asp Thr Ile Leu Ala Ile 
145                 150                 155                 160 


Gln Ala Asp Gly Thr Val Ala Gly Leu His Thr Gly Asp Ala Thr Ile 
                165                 170                 175     


Asp Pro Asp Thr Ile Ser Ala Leu Glu Gln Tyr Ala Ala Lys Val Ser 
            180                 185                 190         


Ile Asp Gly Ser Glu Ser Val Ala Gly Thr Gly Met Ile Gly Glu Asn 
        195                 200                 205             


Glu Gln Glu Lys Lys Met Gln Ile Val Leu Gln Gly His Ala Thr Arg 
    210                 215                 220                 


Val Thr Ala Lys Ser Gln Gln Ser Gly Glu Lys Ala Phe Arg Cys Glu 
225                 230                 235                 240 


Tyr Asp Gly Cys Gly Lys Leu Tyr Thr Thr Ala His His Leu Lys Val 
                245                 250                 255     


His Glu Arg Ser His Thr Gly Asp Arg Pro Tyr Gln Cys Glu His Ala 
            260                 265                 270         


Gly Cys Gly Lys Ala Phe Ala Thr Gly Tyr Gly Leu Lys Ser His Val 
        275                 280                 285             


Arg Thr His Thr Gly Glu Lys Pro Tyr Arg Cys Ser Glu Asp Asn Cys 
    290                 295                 300                 


Thr Lys Ser Phe Lys Thr Ser Gly Asp Leu Gln Lys His Ile Arg Thr 
305                 310                 315                 320 


His Thr Gly Glu Arg Pro Phe Lys Cys Pro Phe Glu Gly Cys Gly Arg 
                325                 330                 335     


Ser Phe Thr Thr Ser Asn Ile Arg Lys Val His Val Arg Thr His Thr 
            340                 345                 350         


Gly Glu Arg Pro Tyr Tyr Cys Thr Glu Pro Gly Cys Gly Arg Ala Phe 
        355                 360                 365             


Ala Ser Ala Thr Asn Tyr Lys Asn His Val Arg Ile His Thr Gly Glu 
    370                 375                 380                 


Lys Pro Tyr Val Cys Thr Val Pro Gly Cys Asp Lys Arg Phe Thr Glu 
385                 390                 395                 400 


Tyr Ser Ser Leu Tyr Lys His His Val Val His Thr His Ser Lys Pro 
                405                 410                 415     


Tyr Asn Cys Asn His Cys Gly Lys Thr Tyr Lys Gln Ile Ser Thr Leu 
            420                 425                 430         


Ala Met His Lys Arg Thr Ala His Asn Asp Thr Glu Pro Ile Glu Glu 
        435                 440                 445             


Glu Gln Glu Ala Phe Phe Glu Pro Pro Pro Gly Gln Gly Glu Asp Val 
    450                 455                 460                 


Leu Lys Gly Ser Gln Ile Thr Tyr Val Thr Gly Val Glu Gly Asp Asp 
465                 470                 475                 480 


Val Val Ser Thr Gln Val Ala Thr Val Thr Gln Ser Gly Leu Ser Gln 
                485                 490                 495     


Gln Val Thr Leu Ile Ser Gln Asp Gly Thr Gln His Val Asn Ile Ser 
            500                 505                 510         


Gln Ala Asp Met Gln Ala Ile Gly Asn Thr Ile Thr Met Val Thr Gln 
        515                 520                 525             


Asp Gly Thr Pro Ile Thr Val Pro Ala His Asp Ala Val Ile Ser Ser 
    530                 535                 540                 


Ala Gly Thr His Ser Val Ala Met Val Thr Ala Glu Gly Thr Glu Gly 
545                 550                 555                 560 


Glu Gln Val Ala Ile Val Ala Gln Asp Leu Ala Ala Phe His Thr Ala 
                565                 570                 575     


Ser Ser Glu Met Gly His Gln Gln His Ser His His Leu Val Thr Thr 
            580                 585                 590         


Glu Thr Arg Pro Leu Thr Leu Val Ala Thr Ser Asn Gly Thr Gln Ile 
        595                 600                 605             


Ala Val Gln Leu Gly Glu Gln Pro Ser Leu Glu Glu Ala Ile Arg Ile 
    610                 615                 620                 


Ala Ser Arg Ile Gln Gln Gly Glu Thr Pro Gly Leu Asp Asp 
625                 630                 635             


<210>  558
<211>  5524
<212>  DNA
<213>  Homo sapiens

<400>  558
cgggtgtgga gcacggggag tcgggcgtgg ggcgggcagg gagtggagtc ggggtcttac       60

tccggtggct gcagggcgca gggtagccgt gtcaggcctg cccaggtgca gagcgctctt      120

ccgcgacccc aacagcctct ggtccggtct ggcgcgccct cgctttccca gagggcgacc      180

tgggctatgg cggccgtggc gctggcgagc gggacacgcc tcggccttgt cctcgagctg      240

ctcccgggac agcccgcgct gccccgggcg cgccgggagt cagtgacctt cgaggatgtg      300

gccgtctact tctctgagaa cgaatggatc ggcctgggcc ctgctcagag agccctgtac      360

agggatgtga tgctggagaa ttatggggct gtggcttccc tggcatttcc atttcccaaa      420

ccggctctga tttcccagct ggagcgaggg gaaacaccct ggtgctcggt tcctcgggga      480

gctctggatg gagaggcccc aaggggcatc tcctcagagg gtgtgttgaa gaggaagaaa      540

gaagatttta ttctgaagga ggaaattatt gaggaagcac aggacctcat ggtcctatca      600

agtggacccc agtggtgtgg atcccaggaa ttatggtttg ggaaaacctg tgaagagaaa      660

agcaggttag ggagatggcc tggttacctc aatgggggac gtatggaaag ttctacaaat      720

gatattatag aagtgattgt caaggatgag atgatctcag tagaagagag ttcagggaat      780

actgatgtca ataacctcct tggtatacat cacaaaattc taaatgagca aatattctat      840

atatgtgagg aatgcggcaa gtgttttgat caaaatgagg actttgatca acaccagaaa      900

actcataatg gagagaaggt ctatggatgt aaggaatgtg ggaaggcttt cagttttcga      960

tcacattgca ttgcacatca gagaattcac agtggggtga aaccctatga atgtcaagaa     1020

tgtgctaagg cctttgtttg gaagtcaaac ctgattcgtc accagagaat acatactgga     1080

gagaaaccct ttgaatgtaa ggaatgtggg aagggcttta gtcagaacac aagccttacg     1140

caacatcaac ggatccacac tggtgagaaa ccatacacat gtaaggaatg tgggaaaagc     1200

tttactcgaa acccagccct tcttcgacat cagagaatgc acactgggga gaagccttac     1260

gaatgtaagg actgtgggaa gggcttcatg tggaactcag atctttctca gcaccagagg     1320

gtccacactg gggacaagcc tcatgaatgt actgactgtg ggaaaagctt cttttgcaag     1380

gcacatctta ttcgacatca aagaatccat actggggaaa gaccctataa atgtaatgac     1440

tgtgggaagg ccttcagtca gaattctgtc ttaattaagc accagaggcg ccatgctaga     1500

gacaaaccct ataactgtca gatctctcac cttcttgaac attagagagt gcataatggt     1560

gatacttgtt tataattctt atgctgcagg aaccctagag acaaaatgag atgaccattc     1620

acaatttgct gtaaccctta acttaaatag ccagtattat cttgcccttt tgaacattta     1680

ccatgtactc tagcaagact ggtccctctg ttctatgatg ttttaacaag gcatcattta     1740

gttgggcagc tactctgtat caggtgctaa ccactttaca tacattaatt tgcataacaa     1800

tcctattaag gtaggtgctc ttctccccat tttacaaatg agaaatctga gttgaaagag     1860

gttataaaac tcattcaggg ttgctcagtt agtaagttat agagttgaaa ttggagccag     1920

gcctatctga ctgcagagtt tactgttctt tacttaattg tacatattta tgtctctgcc     1980

catttttatt tgcttatttt cctgtgcttt tagtttccct tcatcactca gatctagctc     2040

cttcaactaa gaagatctct cttcctcttc tacttgtaat cagtaccacc caagttagta     2100

tttaattatg tgccatctta tatttttcta atagtctcat gtcttttaat cttaacccca     2160

gctaaatgac tctgaggacc aacagtacat ttcttttatg tttttcaaat cctgaaacat     2220

taatctttga ctagatataa catgctcatg ataaaaaaga attgaaatag ttgaaaaggg     2280

tgttcagtga aaagtaaatt tccttgtcat tcctatctct tgagttctcc ccagaggcaa     2340

tcactgctac tggttgtgta tctctgtaga tactctttgt atacaagtgt ttattagtat     2400

tgcttttcat aattctgtct cactgaaaac cttatttgat ggaagcaaca ttgcagttaa     2460

attgtgaact ctaagacctt ttcttcagaa gttgctttcc ttttgaggcc accaaagtaa     2520

tttagggaaa cagcagaggg taatccaggt cttttttttt tttttttttt ttttagacag     2580

agtctcactc tgttgctctg gctggagtgc agtggtgcta tctcagctca ctgcaagctc     2640

cacctcctgg gttcatgcca ttcttctgcc tcagcctccc aagtagctgg gactacaggt     2700

gcccgccacc atgcctggct aatatttttt atttttagta gagacggggt ttcaccatgt     2760

tagccaggct ggtctcgatc tcctgacctt gtgatccacc tgtctcggcc tcccaaagtg     2820

ctgggattac aggcctcagc taccacgcct ggccaatcca ggtcttaaga gacctcattg     2880

cctttgtttt atgagatatc attctgggat tgggaatatg taaactcaac tggagatttt     2940

ttttcataaa aatttatata gttccagccc tctcattgct tcctatccta aatcctcttc     3000

cagtctgtcc atccctcact accatgatag tctacattct gataagctgt gaggccactg     3060

ccaagggagg gagaaatggt cactttctgg tggtggttaa tgctttgtta gatagcttca     3120

tccagtcaat agttgaaaag ttttcacata atccagtatt ggcatcagag ccagaaatgc     3180

cctccctagg tccaggacca aagataaaac aaacacgagg aacatgtagc gtctacacag     3240

gaaagtaaag aattatagaa ttaactaatt ctacttgaaa tcaggagttt tataaaacaa     3300

catttttaga cgtggtcatc ttttattggt ttccatcatc tcttcccctt ctctctggga     3360

acagttaccc gggtattctt tgggaagcta tcctttctca gctatgtggt ttggcaccac     3420

caccatcttc atgagtggac cctgtttggc ttgtgtcaat cagtttatcc catccccttg     3480

gccacagagc cattgtgata tgaggagata ctggctcttc tggaaaagag aggcttttct     3540

tcatcgagag ctaccagagg agatattatc tgtcctctgt gtggcacata ggaaaatgtg     3600

agacctagaa ttatagcaac tttttttttc tgttaaaagg ggagattctc aagcttccag     3660

gtgctaccat atggagccta aggataaagc caataccaaa gaaaacagtg actaaacaga     3720

gagaaactag gtccttggtg acatcttttg agccactaga ccaagcttta cctgaagcag     3780

agctacctca gaacttttca gctatgtgag ccaataaaca tctgtcaaac gagttagagt     3840

tgagttttct gttatttgca acttagccac actaatactg ttttgtgttt gaaatcactg     3900

ttttctcata cagctcctca gtgtcacctt ttcctcttgc tcagtagtct cataagcttc     3960

tcagttttat ctcatctcag ttgcttggaa gttgagcatc taaataggtg gcttttgctg     4020

ggtgcagtgg cttacgcctg taatcccatc actttgggag gccaaggtgg gcagatcacc     4080

tgagattggg agttcaagac cagcctgacc aacatagaga gaccccgtct ctactaaaaa     4140

tacaaaatta gccaggtgtg gtggcacatg ccagtaatct cagctactca ggaggctgag     4200

gcaggagaat tgcttgaatc tgggaggtgg aggttgcagt gagccgagat tgtgccattg     4260

cactccagcc tgggcaacaa gagtgaaact ccatctcaaa aaaatgaaaa taataaatag     4320

gtggctctca tgacctaagg ttaatttcat gcatactact aagtgatgct ttaagtcata     4380

ccattagtgc aggaattttt gctccttagt tcagctaaaa tctgggttct tgtctcatga     4440

ccaggaaaaa ttagtcacag ggacacattg aaaagtgagg agggcagaat ttattaagtg     4500

aaaaggaaaa ctctcaacaa aaagaggggt cctgcatgca ggttttccat ctcactaaac     4560

tgaataccag gccaccacac atgagctgaa gagcctagtc ttctccccct gcatgaattc     4620

ctggtggcta caccccgttc tcccagtgtg caggcaggcc cttagtctga gccactccac     4680

attatttccc ttactgtgta tgtgttaagg aacggaattt ttcatcatgg gcatgtttag     4740

gcaatccccc tgtgcacaat gacctgggca gcatttggct gtctcctgat tctatcattc     4800

ccccctctaa agaagtacat ctaacttaga ataaggataa ggataagggt agtgatcgat     4860

cttaactggt tcctgctgat gggggcactg ttttgggaaa atagcagtga gatctccctc     4920

agaggcctat ctaagggtcc ctggtaaaag gtggccatca tttgaggttc caattgcatg     4980

aacattcaga gttcaatggc ctgaaggtga gaagagacaa accaggttat tagaagacaa     5040

tcaaaatgaa acaaagcggg gatggtaagg acagctaaaa aaaatcctaa ggctgctgac     5100

acacccagat aactggtagc tatagttatg cctgctaaga ttggggtgtt tggggcttgg     5160

ctttcgttag ctcccttggt cttattttcc caaaaaagaa acctccaggt tatgggcacc     5220

ttatttagtc taatcatctg gcaggatttg cagggtaatt gcccagaact agaatattga     5280

tccagatttt tacattactc atcccttttg ctgcttctga gctgcagcca gagattgctg     5340

gttggttcac aggaataagc agtgttagtt taaaatgtgg gcaaaaactt aaaaacaacg     5400

aatgagtcta aaatctaatg acaaatatat aagtcttgaa acataatttc tctccagttc     5460

tcatttttgt taaaaataaa tcatgatagg actgagttgt ttgcaaaata aactttagtc     5520

ttgt                                                                  5524


<210>  559
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  559

Met Ala Ala Val Ala Leu Ala Ser Gly Thr Arg Leu Gly Leu Val Leu 
1               5                   10                  15      


Glu Leu Leu Pro Gly Gln Pro Ala Leu Pro Arg Ala Arg Arg Glu Ser 
            20                  25                  30          


Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu Asn Glu Trp Ile 
        35                  40                  45              


Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu 
    50                  55                  60                  


Asn Tyr Gly Ala Val Ala Ser Leu Ala Phe Pro Phe Pro Lys Pro Ala 
65                  70                  75                  80  


Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro Trp Cys Ser Val Pro 
                85                  90                  95      


Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly Ile Ser Ser Glu Gly 
            100                 105                 110         


Val Leu Lys Arg Lys Lys Glu Asp Phe Ile Leu Lys Glu Glu Ile Ile 
        115                 120                 125             


Glu Glu Ala Gln Asp Leu Met Val Leu Ser Ser Gly Pro Gln Trp Cys 
    130                 135                 140                 


Gly Ser Gln Glu Leu Trp Phe Gly Lys Thr Cys Glu Glu Lys Ser Arg 
145                 150                 155                 160 


Leu Gly Arg Trp Pro Gly Tyr Leu Asn Gly Gly Arg Met Glu Ser Ser 
                165                 170                 175     


Thr Asn Asp Ile Ile Glu Val Ile Val Lys Asp Glu Met Ile Ser Val 
            180                 185                 190         


Glu Glu Ser Ser Gly Asn Thr Asp Val Asn Asn Leu Leu Gly Ile His 
        195                 200                 205             


His Lys Ile Leu Asn Glu Gln Ile Phe Tyr Ile Cys Glu Glu Cys Gly 
    210                 215                 220                 


Lys Cys Phe Asp Gln Asn Glu Asp Phe Asp Gln His Gln Lys Thr His 
225                 230                 235                 240 


Asn Gly Glu Lys Val Tyr Gly Cys Lys Glu Cys Gly Lys Ala Phe Ser 
                245                 250                 255     


Phe Arg Ser His Cys Ile Ala His Gln Arg Ile His Ser Gly Val Lys 
            260                 265                 270         


Pro Tyr Glu Cys Gln Glu Cys Ala Lys Ala Phe Val Trp Lys Ser Asn 
        275                 280                 285             


Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys 
    290                 295                 300                 


Lys Glu Cys Gly Lys Gly Phe Ser Gln Asn Thr Ser Leu Thr Gln His 
305                 310                 315                 320 


Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Lys Glu Cys Gly 
                325                 330                 335     


Lys Ser Phe Thr Arg Asn Pro Ala Leu Leu Arg His Gln Arg Met His 
            340                 345                 350         


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Asp Cys Gly Lys Gly Phe Met 
        355                 360                 365             


Trp Asn Ser Asp Leu Ser Gln His Gln Arg Val His Thr Gly Asp Lys 
    370                 375                 380                 


Pro His Glu Cys Thr Asp Cys Gly Lys Ser Phe Phe Cys Lys Ala His 
385                 390                 395                 400 


Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys 
                405                 410                 415     


Asn Asp Cys Gly Lys Ala Phe Ser Gln Asn Ser Val Leu Ile Lys His 
            420                 425                 430         


Gln Arg Arg His Ala Arg Asp Lys Pro Tyr Asn Cys Gln Ile Ser His 
        435                 440                 445             


Leu Leu Glu His 
    450         


<210>  560
<211>  5612
<212>  DNA
<213>  Homo sapiens

<400>  560
aaatatctgt ccacctaggg tgcagcgagc tggagaggaa ggggtggcct agagcgcagg       60

ggaaggattc ctccccagcc gcctgcaccc ctaccccggt agcggtccct gggatcgtcc      120

gtgtctccag gagaaccgga ccgctctccc ctccctcccc gagcgagaaa ggaggaccac      180

agagatgcgg cgccctccgc cgtcctagag caaccggagc ggcccgagcc ccggcctccc      240

ggatgctggg gcctggcggg agtcagtgac cttcgaggat gtggccgtct acttctctga      300

gaacgaatgg atcggcctgg gccctgctca gagagccctg tacagggatg tgatgctgga      360

gaattatggg gctgtggctt ccctggcagc atttccattt cccaaaccgg ctctgatttc      420

ccagctggag cgaggggaaa caccctggtg ctcggttcct cggggagctc tggatggaga      480

ggccccaagg ggcatctcct caggatatcc atttctaaag cctgctggga tttcccatcc      540

tgagcaggtg gaagagccat taaacctgaa actgcaagga gagggtccaa gcctgatttg      600

tccggagggt gtgttgaaga ggaagaaaga agattttatt ctgaaggagg aaattattga      660

ggaagcacag gacctcatgg tcctatcaag tggaccccag tggtgtggat cccaggaatt      720

atggtttggg aaaacctgtg aagagaaaag caggttaggg agatggcctg gttacctcaa      780

tgggggacgt atggaaagtt ctacaaatga tattatagaa gtgattgtca aggatgagat      840

gatctcagta gaagagagtt cagggaatac tgatgtcaat aacctccttg gtatacatca      900

caaaattcta aatgagcaaa tattctatat atgtgaggaa tgcggcaagt gttttgatca      960

aaatgaggac tttgatcaac accagaaaac tcataatgga gagaaggtct atggatgtaa     1020

ggaatgtggg aaggctttca gttttcgatc acattgcatt gcacatcaga gaattcacag     1080

tggggtgaaa ccctatgaat gtcaagaatg tgctaaggcc tttgtttgga agtcaaacct     1140

gattcgtcac cagagaatac atactggaga gaaacccttt gaatgtaagg aatgtgggaa     1200

gggctttagt cagaacacaa gccttacgca acatcaacgg atccacactg gtgagaaacc     1260

atacacatgt aaggaatgtg ggaaaagctt tactcgaaac ccagcccttc ttcgacatca     1320

gagaatgcac actggggaga agccttacga atgtaaggac tgtgggaagg gcttcatgtg     1380

gaactcagat ctttctcagc accagagggt ccacactggg gacaagcctc atgaatgtac     1440

tgactgtggg aaaagcttct tttgcaaggc acatcttatt cgacatcaaa gaatccatac     1500

tggggaaaga ccctataaat gtaatgactg tgggaaggcc ttcagtcaga attctgtctt     1560

aattaagcac cagaggcgcc atgctagaga caaaccctat aactgtcaga tctctcacct     1620

tcttgaacat tagagagtgc ataatggtga tacttgttta taattcttat gctgcaggaa     1680

ccctagagac aaaatgagat gaccattcac aatttgctgt aacccttaac ttaaatagcc     1740

agtattatct tgcccttttg aacatttacc atgtactcta gcaagactgg tccctctgtt     1800

ctatgatgtt ttaacaaggc atcatttagt tgggcagcta ctctgtatca ggtgctaacc     1860

actttacata cattaatttg cataacaatc ctattaaggt aggtgctctt ctccccattt     1920

tacaaatgag aaatctgagt tgaaagaggt tataaaactc attcagggtt gctcagttag     1980

taagttatag agttgaaatt ggagccaggc ctatctgact gcagagttta ctgttcttta     2040

cttaattgta catatttatg tctctgccca tttttatttg cttattttcc tgtgctttta     2100

gtttcccttc atcactcaga tctagctcct tcaactaaga agatctctct tcctcttcta     2160

cttgtaatca gtaccaccca agttagtatt taattatgtg ccatcttata tttttctaat     2220

agtctcatgt cttttaatct taaccccagc taaatgactc tgaggaccaa cagtacattt     2280

cttttatgtt tttcaaatcc tgaaacatta atctttgact agatataaca tgctcatgat     2340

aaaaaagaat tgaaatagtt gaaaagggtg ttcagtgaaa agtaaatttc cttgtcattc     2400

ctatctcttg agttctcccc agaggcaatc actgctactg gttgtgtatc tctgtagata     2460

ctctttgtat acaagtgttt attagtattg cttttcataa ttctgtctca ctgaaaacct     2520

tatttgatgg aagcaacatt gcagttaaat tgtgaactct aagacctttt cttcagaagt     2580

tgctttcctt ttgaggccac caaagtaatt tagggaaaca gcagagggta atccaggtct     2640

tttttttttt tttttttttt ttagacagag tctcactctg ttgctctggc tggagtgcag     2700

tggtgctatc tcagctcact gcaagctcca cctcctgggt tcatgccatt cttctgcctc     2760

agcctcccaa gtagctggga ctacaggtgc ccgccaccat gcctggctaa tattttttat     2820

ttttagtaga gacggggttt caccatgtta gccaggctgg tctcgatctc ctgaccttgt     2880

gatccacctg tctcggcctc ccaaagtgct gggattacag gcctcagcta ccacgcctgg     2940

ccaatccagg tcttaagaga cctcattgcc tttgttttat gagatatcat tctgggattg     3000

ggaatatgta aactcaactg gagatttttt ttcataaaaa tttatatagt tccagccctc     3060

tcattgcttc ctatcctaaa tcctcttcca gtctgtccat ccctcactac catgatagtc     3120

tacattctga taagctgtga ggccactgcc aagggaggga gaaatggtca ctttctggtg     3180

gtggttaatg ctttgttaga tagcttcatc cagtcaatag ttgaaaagtt ttcacataat     3240

ccagtattgg catcagagcc agaaatgccc tccctaggtc caggaccaaa gataaaacaa     3300

acacgaggaa catgtagcgt ctacacagga aagtaaagaa ttatagaatt aactaattct     3360

acttgaaatc aggagtttta taaaacaaca tttttagacg tggtcatctt ttattggttt     3420

ccatcatctc ttccccttct ctctgggaac agttacccgg gtattctttg ggaagctatc     3480

ctttctcagc tatgtggttt ggcaccacca ccatcttcat gagtggaccc tgtttggctt     3540

gtgtcaatca gtttatccca tccccttggc cacagagcca ttgtgatatg aggagatact     3600

ggctcttctg gaaaagagag gcttttcttc atcgagagct accagaggag atattatctg     3660

tcctctgtgt ggcacatagg aaaatgtgag acctagaatt atagcaactt tttttttctg     3720

ttaaaagggg agattctcaa gcttccaggt gctaccatat ggagcctaag gataaagcca     3780

ataccaaaga aaacagtgac taaacagaga gaaactaggt ccttggtgac atcttttgag     3840

ccactagacc aagctttacc tgaagcagag ctacctcaga acttttcagc tatgtgagcc     3900

aataaacatc tgtcaaacga gttagagttg agttttctgt tatttgcaac ttagccacac     3960

taatactgtt ttgtgtttga aatcactgtt ttctcataca gctcctcagt gtcacctttt     4020

cctcttgctc agtagtctca taagcttctc agttttatct catctcagtt gcttggaagt     4080

tgagcatcta aataggtggc ttttgctggg tgcagtggct tacgcctgta atcccatcac     4140

tttgggaggc caaggtgggc agatcacctg agattgggag ttcaagacca gcctgaccaa     4200

catagagaga ccccgtctct actaaaaata caaaattagc caggtgtggt ggcacatgcc     4260

agtaatctca gctactcagg aggctgaggc aggagaattg cttgaatctg ggaggtggag     4320

gttgcagtga gccgagattg tgccattgca ctccagcctg ggcaacaaga gtgaaactcc     4380

atctcaaaaa aatgaaaata ataaataggt ggctctcatg acctaaggtt aatttcatgc     4440

atactactaa gtgatgcttt aagtcatacc attagtgcag gaatttttgc tccttagttc     4500

agctaaaatc tgggttcttg tctcatgacc aggaaaaatt agtcacaggg acacattgaa     4560

aagtgaggag ggcagaattt attaagtgaa aaggaaaact ctcaacaaaa agaggggtcc     4620

tgcatgcagg ttttccatct cactaaactg aataccaggc caccacacat gagctgaaga     4680

gcctagtctt ctccccctgc atgaattcct ggtggctaca ccccgttctc ccagtgtgca     4740

ggcaggccct tagtctgagc cactccacat tatttccctt actgtgtatg tgttaaggaa     4800

cggaattttt catcatgggc atgtttaggc aatccccctg tgcacaatga cctgggcagc     4860

atttggctgt ctcctgattc tatcattccc ccctctaaag aagtacatct aacttagaat     4920

aaggataagg ataagggtag tgatcgatct taactggttc ctgctgatgg gggcactgtt     4980

ttgggaaaat agcagtgaga tctccctcag aggcctatct aagggtccct ggtaaaaggt     5040

ggccatcatt tgaggttcca attgcatgaa cattcagagt tcaatggcct gaaggtgaga     5100

agagacaaac caggttatta gaagacaatc aaaatgaaac aaagcgggga tggtaaggac     5160

agctaaaaaa aatcctaagg ctgctgacac acccagataa ctggtagcta tagttatgcc     5220

tgctaagatt ggggtgtttg gggcttggct ttcgttagct cccttggtct tattttccca     5280

aaaaagaaac ctccaggtta tgggcacctt atttagtcta atcatctggc aggatttgca     5340

gggtaattgc ccagaactag aatattgatc cagattttta cattactcat cccttttgct     5400

gcttctgagc tgcagccaga gattgctggt tggttcacag gaataagcag tgttagttta     5460

aaatgtgggc aaaaacttaa aaacaacgaa tgagtctaaa atctaatgac aaatatataa     5520

gtcttgaaac ataatttctc tccagttctc atttttgtta aaaataaatc atgataggac     5580

tgagttgttt gcaaaataaa ctttagtctt gt                                   5612


<210>  561
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  561

Met Leu Glu Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro Phe 
1               5                   10                  15      


Pro Lys Pro Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro Trp 
            20                  25                  30          


Cys Ser Val Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly Ile 
        35                  40                  45              


Ser Ser Gly Tyr Pro Phe Leu Lys Pro Ala Gly Ile Ser His Pro Glu 
    50                  55                  60                  


Gln Val Glu Glu Pro Leu Asn Leu Lys Leu Gln Gly Glu Gly Pro Ser 
65                  70                  75                  80  


Leu Ile Cys Pro Glu Gly Val Leu Lys Arg Lys Lys Glu Asp Phe Ile 
                85                  90                  95      


Leu Lys Glu Glu Ile Ile Glu Glu Ala Gln Asp Leu Met Val Leu Ser 
            100                 105                 110         


Ser Gly Pro Gln Trp Cys Gly Ser Gln Glu Leu Trp Phe Gly Lys Thr 
        115                 120                 125             


Cys Glu Glu Lys Ser Arg Leu Gly Arg Trp Pro Gly Tyr Leu Asn Gly 
    130                 135                 140                 


Gly Arg Met Glu Ser Ser Thr Asn Asp Ile Ile Glu Val Ile Val Lys 
145                 150                 155                 160 


Asp Glu Met Ile Ser Val Glu Glu Ser Ser Gly Asn Thr Asp Val Asn 
                165                 170                 175     


Asn Leu Leu Gly Ile His His Lys Ile Leu Asn Glu Gln Ile Phe Tyr 
            180                 185                 190         


Ile Cys Glu Glu Cys Gly Lys Cys Phe Asp Gln Asn Glu Asp Phe Asp 
        195                 200                 205             


Gln His Gln Lys Thr His Asn Gly Glu Lys Val Tyr Gly Cys Lys Glu 
    210                 215                 220                 


Cys Gly Lys Ala Phe Ser Phe Arg Ser His Cys Ile Ala His Gln Arg 
225                 230                 235                 240 


Ile His Ser Gly Val Lys Pro Tyr Glu Cys Gln Glu Cys Ala Lys Ala 
                245                 250                 255     


Phe Val Trp Lys Ser Asn Leu Ile Arg His Gln Arg Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Gly Phe Ser Gln Asn 
        275                 280                 285             


Thr Ser Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Thr Cys Lys Glu Cys Gly Lys Ser Phe Thr Arg Asn Pro Ala Leu Leu 
305                 310                 315                 320 


Arg His Gln Arg Met His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Asp 
                325                 330                 335     


Cys Gly Lys Gly Phe Met Trp Asn Ser Asp Leu Ser Gln His Gln Arg 
            340                 345                 350         


Val His Thr Gly Asp Lys Pro His Glu Cys Thr Asp Cys Gly Lys Ser 
        355                 360                 365             


Phe Phe Cys Lys Ala His Leu Ile Arg His Gln Arg Ile His Thr Gly 
    370                 375                 380                 


Glu Arg Pro Tyr Lys Cys Asn Asp Cys Gly Lys Ala Phe Ser Gln Asn 
385                 390                 395                 400 


Ser Val Leu Ile Lys His Gln Arg Arg His Ala Arg Asp Lys Pro Tyr 
                405                 410                 415     


Asn Cys Gln Ile Ser His Leu Leu Glu His 
            420                 425     


<210>  562
<211>  3194
<212>  DNA
<213>  Homo sapiens

<400>  562
agtcgaggta tcttctcccc aaccactgct cttattttaa ttattgcaga cggaagttga       60

agactattga catagtaaat agctctgggt ggcttgaaac gaaagtttaa ctttgcggac      120

aaacaggact tattgtaggg ggtggtcaaa atagtcccgg cggggcgggg ccatgacccc      180

tgacgtcgcc ggtccggcgc gcagttcagt ttggcggttc cggtaccgct ctcacattgg      240

ggcgggatgt gggagcggct gaactgcgca gcagaggact tttattctcg tctccttcag      300

aaatttaatg aagaaaagaa aggaatccgt aaagacccat ttctctatga ggctgatgtc      360

caagtgcagt tgatcagcaa aggccaacca aaccctttga aaaatattct aaatgaaaat      420

gacatagtat tcatagtgga aaaagtgcct ttagaaaagg aagaaacaag tcatattgaa      480

gaacttcaat ctgaagaaac tgccatatct gatttctcta ctggcgaaaa tgttggacca      540

cttgctttac cagttgggaa ggcaaggcag ttaattggac tttacaccat ggctcacaat      600

cctaatatga cccatttgaa gattaatctg ccagttactg cccttcctcc cctttgggta      660

agatgtgaca gttcagatcc tgaaggtact tgttggctag gagctgagct tatcacaaca      720

aacaacagca ttacaggaat tgtcttatat gtggtcagtt gtaaagctga taaaaattat      780

tctgtaaatc ttgaaaacct aaaaaattta cacaagaaaa gacatcactt gtctactgta      840

acatccaaag gctttgccca gtatgagctc tttaagtcct ctgccttgga tgatacaatc      900

acagcatcac aaactgcgat cgctttggat atttcctgga gtcctgtgga tgagattctt      960

caaatccctc cactctcttc aactgcaact ctgaatatta aagtggaatc aggagagccc     1020

agaggtcctt tgaatcatct ctacagagaa ctgaaatttc ttcttgtttt ggctgatggt     1080

ttgaggactg gtgtcactga atggctcgag cccctggaag caaaatctgc tgttgaactt     1140

gttcaggaat ttctgaatga cttaaataag ctggatggat ttggtgattc tacaaaaaaa     1200

gacactgagg ttgagacctt gaagcatgac actgctgcag tcgatcgttc cgtcaagcgt     1260

cttttcaaag ttcggagtga tcttgatttt gctgagcaac tgtggtgcaa aatgagcagt     1320

agtgtgattt cataccaaga cttggtgaag tgtttcacat tgatcatcca gagtctacaa     1380

cgtggtgata tacagccatg gctccatagt ggaagtaaca gtttactaag taagctcatt     1440

catcagtctt atcatggaac catggacaca gtttctctca gtgggactat tccagttcaa     1500

atgcttttgg aaattggttt ggacaaacta aagaaagatt atatcagttt tttcataggt     1560

caggaacttg catctttgaa tcatttggaa tacttcattg ctccatcagt agatatacaa     1620

gaacaggttt atcgtgtcca aaaactccac catattctag aaatattagt cagttgcatg     1680

cctttcatta aatctcaaca tgaactcctc ttttctttaa cacagatctg cataaagtat     1740

tacaaacaaa atcctcttga tgagcaacac atttttcagc tgccagtcag accaactgct     1800

gtaaagaact tatatcaaag tgagaagcca cagaaatgga gagtggaaat atatagtggt     1860

caaaagaaga ttaagacagt ttggcaactg agtgacagct cacccataga ccatctgaat     1920

tttcacaaac ctgatttttc ggaattaaca ctaaacggta gcctggaaga aaggatattc     1980

tttactaaca tggttacctg cagccaggtg catttcaagt gaagtgtgct gatgaagtcc     2040

tctataagca caagccaaaa agagaaagag aaaaaaaggt aattattgta gaacctgaaa     2100

acagcaatgt atggaaaccc tcaaagcaga aaagggagga agatcctgaa gattctctta     2160

tgaagctcca aaattgataa tcctgtctca gctctgcctc ctcaggagga gcattagtag     2220

aacagcagtg atgaggacac agagggagca gacagtgggt accacgatct ccgtaaccat     2280

ttgcatgtga cttagcaagg gctctgaaat gacaaagaga acgagcacca caaatgagaa     2340

caggatcatt ttagtaaata cagctttatc ccaaaagctt taactgtatt gggaaaactt     2400

aaaaaatagc atcctcaaat tttctgattc ttatttgcca tgaaatagaa cttagtaaat     2460

taaatgttat ttgaaaatgt tataagagct ttgtaaatat ttcagaaaat atgggataaa     2520

tgcctgaatt tggttcttct acaggtgcta taataaagtc catctctcaa tacttatact     2580

ttctaaattc atctcagaat attagcagcc atattccaca gttcctataa tttttactgg     2640

gggggatttg tgataggaaa gtccttggga aacatttcca atctttcaaa atattattgt     2700

gtatcttaag aagtatagga acttgtatgt tgaaatgttg tatggtagtt cttgtatagt     2760

taaataataa tctttttaag agttaatgat aagcatatgt tatgtgcatt attaataaaa     2820

tagtggccac ttaggtaata cccactttta tcttgtgtgc tgggtactct ggttactgag     2880

ataaataagg cactggacat cctcacgtgg agttcacagg ctcatcagtg aattctgtac     2940

cacatttcaa ccttgtttat tttagtttaa tggaatatac attcttagta ttgcctgatt     3000

atttaaattt gttgaggggg attgcatgtt gctttattgg cctgtaaaaa tagctagttt     3060

ggtaagattt ggtctcgcac cttccatctt tgctaccaca ttaaagatga gcttgttaaa     3120

aaggaaagca tatttctctg attgccctta tggagaaata aagataaaat tcaaagaaac     3180

aaaaaaaaaa aaaa                                                       3194


<210>  563
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  563

Met Trp Glu Arg Leu Asn Cys Ala Ala Glu Asp Phe Tyr Ser Arg Leu 
1               5                   10                  15      


Leu Gln Lys Phe Asn Glu Glu Lys Lys Gly Ile Arg Lys Asp Pro Phe 
            20                  25                  30          


Leu Tyr Glu Ala Asp Val Gln Val Gln Leu Ile Ser Lys Gly Gln Pro 
        35                  40                  45              


Asn Pro Leu Lys Asn Ile Leu Asn Glu Asn Asp Ile Val Phe Ile Val 
    50                  55                  60                  


Glu Lys Val Pro Leu Glu Lys Glu Glu Thr Ser His Ile Glu Glu Leu 
65                  70                  75                  80  


Gln Ser Glu Glu Thr Ala Ile Ser Asp Phe Ser Thr Gly Glu Asn Val 
                85                  90                  95      


Gly Pro Leu Ala Leu Pro Val Gly Lys Ala Arg Gln Leu Ile Gly Leu 
            100                 105                 110         


Tyr Thr Met Ala His Asn Pro Asn Met Thr His Leu Lys Ile Asn Leu 
        115                 120                 125             


Pro Val Thr Ala Leu Pro Pro Leu Trp Val Arg Cys Asp Ser Ser Asp 
    130                 135                 140                 


Pro Glu Gly Thr Cys Trp Leu Gly Ala Glu Leu Ile Thr Thr Asn Asn 
145                 150                 155                 160 


Ser Ile Thr Gly Ile Val Leu Tyr Val Val Ser Cys Lys Ala Asp Lys 
                165                 170                 175     


Asn Tyr Ser Val Asn Leu Glu Asn Leu Lys Asn Leu His Lys Lys Arg 
            180                 185                 190         


His His Leu Ser Thr Val Thr Ser Lys Gly Phe Ala Gln Tyr Glu Leu 
        195                 200                 205             


Phe Lys Ser Ser Ala Leu Asp Asp Thr Ile Thr Ala Ser Gln Thr Ala 
    210                 215                 220                 


Ile Ala Leu Asp Ile Ser Trp Ser Pro Val Asp Glu Ile Leu Gln Ile 
225                 230                 235                 240 


Pro Pro Leu Ser Ser Thr Ala Thr Leu Asn Ile Lys Val Glu Ser Gly 
                245                 250                 255     


Glu Pro Arg Gly Pro Leu Asn His Leu Tyr Arg Glu Leu Lys Phe Leu 
            260                 265                 270         


Leu Val Leu Ala Asp Gly Leu Arg Thr Gly Val Thr Glu Trp Leu Glu 
        275                 280                 285             


Pro Leu Glu Ala Lys Ser Ala Val Glu Leu Val Gln Glu Phe Leu Asn 
    290                 295                 300                 


Asp Leu Asn Lys Leu Asp Gly Phe Gly Asp Ser Thr Lys Lys Asp Thr 
305                 310                 315                 320 


Glu Val Glu Thr Leu Lys His Asp Thr Ala Ala Val Asp Arg Ser Val 
                325                 330                 335     


Lys Arg Leu Phe Lys Val Arg Ser Asp Leu Asp Phe Ala Glu Gln Leu 
            340                 345                 350         


Trp Cys Lys Met Ser Ser Ser Val Ile Ser Tyr Gln Asp Leu Val Lys 
        355                 360                 365             


Cys Phe Thr Leu Ile Ile Gln Ser Leu Gln Arg Gly Asp Ile Gln Pro 
    370                 375                 380                 


Trp Leu His Ser Gly Ser Asn Ser Leu Leu Ser Lys Leu Ile His Gln 
385                 390                 395                 400 


Ser Tyr His Gly Thr Met Asp Thr Val Ser Leu Ser Gly Thr Ile Pro 
                405                 410                 415     


Val Gln Met Leu Leu Glu Ile Gly Leu Asp Lys Leu Lys Lys Asp Tyr 
            420                 425                 430         


Ile Ser Phe Phe Ile Gly Gln Glu Leu Ala Ser Leu Asn His Leu Glu 
        435                 440                 445             


Tyr Phe Ile Ala Pro Ser Val Asp Ile Gln Glu Gln Val Tyr Arg Val 
    450                 455                 460                 


Gln Lys Leu His His Ile Leu Glu Ile Leu Val Ser Cys Met Pro Phe 
465                 470                 475                 480 


Ile Lys Ser Gln His Glu Leu Leu Phe Ser Leu Thr Gln Ile Cys Ile 
                485                 490                 495     


Lys Tyr Tyr Lys Gln Asn Pro Leu Asp Glu Gln His Ile Phe Gln Leu 
            500                 505                 510         


Pro Val Arg Pro Thr Ala Val Lys Asn Leu Tyr Gln Ser Glu Lys Pro 
        515                 520                 525             


Gln Lys Trp Arg Val Glu Ile Tyr Ser Gly Gln Lys Lys Ile Lys Thr 
    530                 535                 540                 


Val Trp Gln Leu Ser Asp Ser Ser Pro Ile Asp His Leu Asn Phe His 
545                 550                 555                 560 


Lys Pro Asp Phe Ser Glu Leu Thr Leu Asn Gly Ser Leu Glu Glu Arg 
                565                 570                 575     


Ile Phe Phe Thr Asn Met Val Thr Cys Ser Gln Val His Phe Lys 
            580                 585                 590     


<210>  564
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  564
caccgccgug aagauuggaa uaauu                                             25


<210>  565
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  565
gaacaggccu ggaugaucca gaaau                                             25


<210>  566
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  566
ggcaagccau cugaugccuu aauuu                                             25


<210>  567
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  567
cagcccggcg auauugucau uauug                                             25


<210>  568
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  568
ccggcgauau ugucauuauu gauca                                             25


<210>  569
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  569
cagcaaauuu cagagaaggc cugaa                                             25


<210>  570
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  570
gagaauucuu auuacaggcu cugaa                                             25


<210>  571
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  571
cagcgucagc uacacugggc auuaa                                             25


<210>  572
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  572
ccuuuaaugg agaggugcuu cauau                                             25


<210>  573
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  573
uacuccacuu cagccaccau ccaua                                             25


<210>  574
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  574
gaagauccag uagaauacuu ggaaa                                             25


<210>  575
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  575
cggagauccu uucuaagaaa uguaa                                             25


<210>  576
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  576
ccaauccauc aauucuccau agaaa                                             25


<210>  577
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  577
cagaacgaua uggauuccaa uacau                                             25


<210>  578
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  578
gcagcaauag gaaauggagu cuuau                                             25


<210>  579
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  579
cguugaguga acggcuccuu caguu                                             25


<210>  580
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  580
cccaccucag uacccucaug uugua                                             25


<210>  581
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  581
acuagcucau gagaccacca cugcu                                             25


<210>  582
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  582
ccgcauugag aagcuggaaa gcgaa                                             25


<210>  583
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  583
ugcaagacuu caaccgggau cuuag                                             25


<210>  584
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  584
uacuguccaa gaagcuggaa cauua                                             25


<210>  585
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  585
uccucuaaug caugcagcau auaaa                                             25


<210>  586
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  586
gagccgaugu aaauugucau cagca                                             25


<210>  587
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  587
ccgauguaaa uugucaucag cauga                                             25


<210>  588
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  588
cacagcccuc auguuugcug cacuu                                             25


<210>  589
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  589
cggcaccgau gaagacgcca uuauu                                             25


<210>  590
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  590
ggcaccgaug aagacgccau uauua                                             25


<210>  591
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  591
acgccauuau uagcguccuu gccua                                             25


<210>  592
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  592
gagaucagga cagccuacaa gagca                                             25


<210>  593
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  593
caucguucau guuccagcga gugcu                                             25


<210>  594
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  594
ggguuucuga gucccuucaa cauga                                             25


<210>  595
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  595
cagcccacaa uaaagacguc cuucg                                             25


<210>  596
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  596
ccacgacguu cguuauggug gucau                                             25


<210>  597
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  597
cgacguucgu uauggugguc auguu                                             25


<210>  598
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  598
uauggugguc auguuggcga gcuau                                             25


<210>  599
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  599
cacagacuuc uacgugccug ugucu                                             25


<210>  600
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  600
caucgauuuc uaggcauccc guacu                                             25


<210>  601
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  601
gacaauggac cugagaccau gcgua                                             25


<210>  602
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  602
ugcccaaugu caccuuggau ggcuu                                             25


<210>  603
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  603
ccaaugucac cuuggauggc uuuga                                             25


<210>  604
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  604
ugaaggagcu gaacggccuu aagaa                                             25


<210>  605
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  605
acggccuuaa gaagcucaag cggaa                                             25


<210>  606
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  606
cggccuuaag aagcucaagc ggaaa                                             25


<210>  607
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  607
gggaaaguuc cuacucguca auuuc                                             25


<210>  608
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  608
ggaaaguucc uacucgucaa uuuca                                             25


<210>  609
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  609
cacagcgaau ugguuggaga gauua                                             25


<210>  610
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  610
cagagauauc aaaugggacu uuaca                                             25


<210>  611
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  611
caaaugggac uuuacaccuu gcaaa                                             25


<210>  612
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  612
caauaugccu guugcugcua gagaa                                             25


<210>  613
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  613
gcugcuagag aagccucuau uuaua                                             25


<210>  614
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  614
gcaggaauga uagucagacg uguua                                             25


<210>  615
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  615
caggaaugau agucagacgu guuau                                             25


<210>  616
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  616
ggguauugug gagaagaccu gugca                                             25


<210>  617
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  617
cgauuggcac agaugagcau auguu                                             25


<210>  618
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  618
cccaucgcag uacagugcua uuaaa                                             25


<210>  619
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  619
ucucuguagu ugauugcccu gauuu                                             25


<210>  620
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  620
aggaacccuu uaccuuuccu guaaa                                             25


<210>  621
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  621
cagaaguugg aggugugccu uacuu                                             25


<210>  622
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  622
gaaguuggag gugugccuua cuuau                                             25


<210>  623
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  623
ugccuuacuu auugccucuu guaaa                                             25


<210>  624
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  624
cagccacuac ugucuuuaca gcuau                                             25


<210>  625
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  625
uccagguuac cgaguugguu guuau                                             25


<210>  626
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  626
ccagguuacc gaguugguug uuauu                                             25


<210>  627
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  627
gagcagcugg uuugaggaug uugua                                             25


<210>  628
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  628
gaggauguug uaugcccaau ccaaa                                             25


<210>  629
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  629
gcauuccuug uaucgucauu ccagu                                             25


<210>  630
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  630
ucgucauucc aguucugcuc uggau                                             25


<210>  631
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  631
ucguuagucg uauauggccu aagaa                                             25


<210>  632
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  632
cguuagucgu auauggccua agaaa                                             25


<210>  633
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  633
aaacuuuaag ggugcagaca ugaau                                             25


<210>  634
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  634
aggguugccu cagaaugcaa gagcu                                             25


<210>  635
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  635
ccggaagcug ccaccuaaua uuguu                                             25


<210>  636
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  636
agcugccacc uaauauuguu cugaa                                             25


<210>  637
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  637
caagaugagc cuggacucca cuuaa                                             25


<210>  638
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  638
uccaggcaau guugcagcua gcaaa                                             25


<210>  639
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  639
gagagaucuu cuauccacau ggaca                                             25


<210>  640
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  640
gcagauguuc uauccaacau ggaaa                                             25


<210>  641
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  641
uccaacauag gaaccaugaa cugua                                             25


<210>  642
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  642
cacaaaggaa gauguucuau ccaaa                                             25


<210>  643
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  643
gggagaucuu cuauccaaua uguaa                                             25


<210>  644
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  644
caggccaaau uugaguuuca ucaug                                             25


<210>  645
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  645
ggccaaauuu gaguuucauc auggu                                             25


<210>  646
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  646
ccaaauuuga guuucaucau gguga                                             25


<210>  647
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  647
ugaguuucau cauggugacu augaa                                             25


<210>  648
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  648
gaguuucauc auggugacua ugaaa                                             25


<210>  649
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  649
ccaucuauuu cgaccaggua uuagu                                             25


<210>  650
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  650
ccacuuugau cuugcuucca guaua                                             25


<210>  651
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  651
cacuuugauc uugcuuccag uauau                                             25


<210>  652
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  652
cagacaaacc auccagguca guuua                                             25


<210>  653
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  653
ccauccaggu caguuuaaug cagaa                                             25


<210>  654
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  654
acugcugcug gaguuugaau cgaaa                                             25


<210>  655
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  655
ccuugucccg ggagcuuaag guuaa                                             25


<210>  656
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  656
cccgggagcu uaagguuaaa cuacu                                             25


<210>  657
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  657
ccaacuucgu gaagaugcau caacu                                             25


<210>  658
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  658
cagcgccgcu gugaugacau ugaaa                                             25


<210>  659
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  659
cagguggaac cggaaucgga auuua                                             25


<210>  660
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  660
gaaccggaau cggaauuuau cauua                                             25


<210>  661
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  661
gauccagaug ccaggaacaa uuuaa                                             25


<210>  662
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  662
cggcauacug auauggaccg uauuu                                             25


<210>  663
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  663
agccacaucc cugucuucau cagaa                                             25


<210>  664
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  664
ccaaugguca gaagcaggaa uuuaa                                             25


<210>  665
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  665
cagaacaacu gaaauggcuc uggaa                                             25


<210>  666
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  666
caaagaagua cgaagagcaa guauu                                             25


<210>  667
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  667
cagcguuugc uggguagcaa cucaa                                             25


<210>  668
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  668
ucagagauga uauucugcug cuuaa                                             25


<210>  669
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  669
caaacaaaga gaacuugcuc gauau                                             25


<210>  670
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  670
aaguaagcca aagacugacu cuuau                                             25


<210>  671
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  671
cacaaagcag gacuuuccca guaaa                                             25


<210>  672
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  672
ccuaauuuga caguuggcag auuua                                             25


<210>  673
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  673
gcacagacuu uggacuccaa guuga                                             25


<210>  674
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  674
ucuagccuug cagggugcca gauua                                             25


<210>  675
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  675
gggagcuaug cagcuauauu cugua                                             25


<210>  676
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  676
gaagaacucu uugcccggaa auuua                                             25


<210>  677
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  677
ccagccaggu caaacuucuc cucua                                             25


<210>  678
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  678
caggucaaac uucuccucua cuuca                                             25


<210>  679
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  679
ggugaaugca ggucuugccu ggaaa                                             25


<210>  680
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  680
caugagaauu uauacaaccu gccaa                                             25


<210>  681
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  681
agaauuuaua caaccugcca accua                                             25


<210>  682
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  682
ccaaccuagc ugguccucug ugaaa                                             25


<210>  683
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  683
ucagccaguu gacuguggau gugaa                                             25


<210>  684
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  684
cagucaccau gugucuuuca gagua                                             25


<210>  685
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  685
cagauggcuu cgaaauggaa cagaa                                             25


<210>  686
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  686
ccacauucac cagagaucau cuaua                                             25


<210>  687
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  687
gagaucaucu auagcugggu auuua                                             25


<210>  688
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  688
caaacaucag auguuggcag cuaua                                             25


<210>  689
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  689
ccugaaauug cgaucagaua uugca                                             25


<210>  690
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  690
cagauauugc aguaccgauu ccaaa                                             25


<210>  691
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  691
gacauacauu cgcucuggua cuuau                                             25


<210>  692
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  692
gauaaugcau cugcuuucaa gaaag                                             25


<210>  693
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  693
gcucuugcag cagaccacac uguuu                                             25


<210>  694
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  694
gccaagacuc uaugaugaaa cuaaa                                             25


<210>  695
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  695
ggucagcaau uugaccagau cucua                                             25


<210>  696
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  696
caggaagagg cagaaggacu gcuaa                                             25


<210>  697
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  697
gagcagacuu cuucugggac uuuga                                             25


<210>  698
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  698
cagaccauga ugacuuugau gcuaa                                             25


<210>  699
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  699
gccaacaggu gagauugaaa ucaaa                                             25


<210>  700
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  700
aauaucucug uaaucugcau ggguu                                             25


<210>  701
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  701
ccgauguuau cgagaugaag guuca                                             25


<210>  702
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  702
caagaccaga cagacagccu gaguu                                             25


<210>  703
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  703
cagacagccu gaguuuacuc agauu                                             25


<210>  704
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  704
ggaugaacac uugugugcca accug                                             25


<210>  705
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  705
gaugaacacu ugugugccaa ccuga                                             25


<210>  706
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  706
acuugugugc caaccugaug cagcu                                             25


<210>  707
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  707
ugcugaugcc uagccaguug guaag                                             25


<210>  708
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  708
ugguaagcca ggugggcaaa gaacu                                             25


<210>  709
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  709
gaccaggaag uagcuuugcu cauuu                                             25


<210>  710
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  710
cagccuucau uuggcccaug uugau                                             25


<210>  711
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  711
caggucgacu gauagaucau gugaa                                             25


<210>  712
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  712
cagagacauc cugaucgacc cuauu                                             25


<210>  713
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  713
gcgucuggua gaauuuaccu cuuca                                             25


<210>  714
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  714
cauacacgag caauuugcca uucuu                                             25


<210>  715
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  715
gcgggaguuu gaucaggaau cugaa                                             25


<210>  716
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  716
gcugcccaau gaaucgaccu uauuu                                             25


<210>  717
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  717
gagaugacau uuguguucag cauga                                             25


<210>  718
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  718
gcaccaugau caaucagaag cuuca                                             25


<210>  719
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  719
ccucuaccuu ggaagugccu accau                                             25


<210>  720
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  720
uaccuuggaa gugccuacca ugcau                                             25


<210>  721
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  721
gcgacccacc uacacuacaa augga                                             25


<210>  722
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  722
caagaagcaa uagacuucau ugacu                                             25


<210>  723
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  723
agacuucauu gacuguguca gggaa                                             25


<210>  724
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  724
cagacagaga guugcaggau gcguu                                             25


<210>  725
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  725
cagcaccuca gaacaaggac cagaa                                             25


<210>  726
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  726
gaacaaggac cagaaagcug uugau                                             25


<210>  727
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  727
cagaagacga cuuccagcga gagau                                             25


<210>  728
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  728
cccuacgaag cgacccacug auuau                                             25


<210>  729
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  729
aagugaaucu uuggaaacaa a                                                 21


<210>  730
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  730
caccuguaag auuuaccagu a                                                 21


<210>  731
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  731
aaggaauauc auuuaaagcu a                                                 21


<210>  732
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  732
caagucugua augaaguguu a                                                 21


<210>  733
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  733
ccgguuucuu guuauggcuu cugau                                             25


<210>  734
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  734
cgguuucuug uuauggcuuc ugauu                                             25


<210>  735
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  735
gggucugaau uggauggaag gcgau                                             25


<210>  736
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  736
uccugacaag uugagugauu gugau                                             25


<210>  737
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  737
aaggaagcaa cauccuggau gguaa                                             25


<210>  738
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  738
cccacuguug agguugaucu cuuca                                             25


<210>  739
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  739
caguggugcu ucaacuggua ucuau                                             25


<210>  740
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  740
ccgggacaau gauaagacuc gcuau                                             25


<210>  741
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  741
cgggacaaug auaagacucg cuaua                                             25


<210>  742
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  742
ucaaaggcug uugagcacau caaua                                             25


<210>  743
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  743
ccucucggag cucaccggau uuaua                                             25


<210>  744
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  744
caccggauuu auaacgacag aaguu                                             25


<210>  745
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  745
cgacgucagu cugaacauca guuua                                             25


<210>  746
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  746
gcgaguuggu ugggcuugac auuca                                             25


<210>  747
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  747
ccagaacauc cacggagcuu ucaau                                             25


<210>  748
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  748
gaucaccagu uaugcagcaa cuuua                                             25


<210>  749
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  749
caucagcugu uugagcucua ucgua                                             25


<210>  750
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  750
gccagaauug auguggguuu auuua                                             25


<210>  751
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  751
cagacagagu aaugguugca uugaa                                             25


<210>  752
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  752
cagaaccggu uugaaguccu gaguu                                             25


<210>  753
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  753
ccaguguagu uagugaaguu guacu                                             25


<210>  754
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  754
ggagcaccuu caaccugaug uauua                                             25


<210>  755
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  755
acgcaguacu aagaguuguu gauuu                                             25


<210>  756
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  756
ccaagaucaa cauuaugcgc uugua                                             25


<210>  757
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  757
caacaucgua uauacugguu gugca                                             25


<210>  758
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  758
ccgaaauccc uacuguggcu augau                                             25


<210>  759
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  759
caucuugaac ucugcugccu ucuuu                                             25


<210>  760
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  760
ggguggugga uuaccagaau ggguu                                             25


<210>  761
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  761
caacuccagu ggaccugauu gggua                                             25


<210>  762
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  762
gaccagugga ggcccagaaa guuua                                             25


<210>  763
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  763
ccacuguccc aucaaaucgc gcaaa                                             25


<210>  764
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  764
aauagagcga cgaacugagc uguaa                                             25


<210>  765
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  765
ucuacacaug gaagguccaa cuuua                                             25


<210>  766
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  766
cagccucauu aauggugaaa cagau                                             25


<210>  767
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  767
cagaugaaag uaguguacca gagcu                                             25


<210>  768
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  768
ccaccuugag cugugaaccu gauau                                             25


<210>  769
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  769
gggaacaucu uugugaucga cugaa                                             25


<210>  770
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  770
ucccauucau gugccuccag guuau                                             25


<210>  771
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  771
cgaaugauuc agacuugcaa gaaua                                             25


<210>  772
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  772
caggcaagag caguuguguu guccu                                             25


<210>  773
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  773
caugugaggg uguaugccau guaca                                             25


<210>  774
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  774
ccaagaggug gugugcuaca cauua                                             25


<210>  775
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  775
uagaagauau caggaaggaa gugaa                                             25


<210>  776
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  776
gaaggaagug aauagagcuu cuaaa                                             25


<210>  777
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  777
caugcaccau uugcuuggaa uuuau                                             25


<210>  778
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  778
cgcuugguuu cauagagacu guuua                                             25


<210>  779
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  779
gagauguuga gaaugggaau ucaua                                             25


<210>  780
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  780
caagaacuca ggacggugaa uggcu                                             25


<210>  781
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  781
ucaggacggu gaauggcucu cagau                                             25


<210>  782
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  782
ucggaccaac ugcuggcaga aucuu                                             25


<210>  783
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  783
gaccaacugc uggcagaauc uucgu                                             25


<210>  784
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  784
ccagaugaag uaaugagcuu ucagu                                             25


<210>  785
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  785
ucugccucau ugaauagcuu gcuuu                                             25


<210>  786
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  786
cacuauugac ugggaaggua cuucu                                             25


<210>  787
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  787
uaucccagaa caacuguccu gugaa                                             25


<210>  788
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  788
gaaaguguug gaugaggauu cugau                                             25


<210>  789
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  789
ugggccaagu guaaccagcu cuuug                                             25


<210>  790
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  790
gggccaagug uaaccagcuc uuuga                                             25


<210>  791
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  791
ugcaagaccu gguggaccau gucaa                                             25


<210>  792
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  792
gaccuggugg accaugucaa cgauu                                             25


<210>  793
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  793
gaccauguca acgauuacca uguca                                             25


<210>  794
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  794
gccagcacca uagggcacua ugaua                                             25


<210>  795
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  795
ccagcaccau agggcacuau gauau                                             25


<210>  796
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  796
caccauaggg cacuaugaua uuaau                                             25


<210>  797
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  797
gcucaugucu guucaagaga guuua                                             25


<210>  798
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  798
caugucuguu caagagaguu uagaa                                             25


<210>  799
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  799
gaccggaacu uucagcugag gcaaa                                             25


<210>  800
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  800
ccaguuccca caaugugcaa gauug                                             25


<210>  801
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  801
ugccacguuc ugugaagacu gugcu                                             25


<210>  802
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  802
ccacguucug ugaagacugu gcugu                                             25


<210>  803
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  803
acguucugug aagacugugc ugucu                                             25


<210>  804
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  804
ggucaacguc uugaaaggag ugcuu                                             25


<210>  805
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  805
ucaacgucuu gaaaggagug cuuau                                             25


<210>  806
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  806
caacgucuug aaaggagugc uuaua                                             25


<210>  807
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  807
cgucuugaaa ggagugcuua uagaa                                             25


<210>  808
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  808
gaaaggagug cuuauagaau gugau                                             25


<210>  809
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  809
caguggcgua uauuguugcc guguu                                             25


<210>  810
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  810
ccgugggugg uucaaugaca ugaaa                                             25


<210>  811
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  811
gacaacaacu gucucuaccu uuguu                                             25


<210>  812
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  812
gaaccaugaa ccaguagcca cuuca                                             25


<210>  813
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  813
gagaacccac cagcucacca uugua                                             25


<210>  814
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  814
ccaauguggc cagaugaccu gcaaa                                             25


<210>  815
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  815
cgaauuugcu gacugggcuc aggaa                                             25


<210>  816
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  816
gcgaguggau gauccagcaa auagg                                             25


<210>  817
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  817
gaggguuucc uaucgcugaa guguu                                             25


<210>  818
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  818
ccuaucgcug aaguguucac gcuga                                             25


<210>  819
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  819
caguacgacu ucguggacua ccauu                                             25


<210>  820
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  820
ggacuaccau uugguugcag caaag                                             25


<210>  821
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  821
ggccuucgug caguuugcuu caaag                                             25


<210>  822
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  822
cagaaguagc aggagugaaa ucaaa                                             25


<210>  823
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  823
gggaccauau gauagaccaa uagga                                             25


<210>  824
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  824
ccgaccggcu gaggcggcgc ggcag                                             25


<210>  825
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  825
ccggcugagg cggcgcggca gcgga                                             25


<210>  826
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  826
cggcugaggc ggcgcggcag cggag                                             25


<210>  827
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  827
ccuucaggag uugaucucua augcu                                             25


<210>  828
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  828
cccuuccaag uuggacggug guaaa                                             25


<210>  829
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  829
agccauugcc aagucuggua cugaa                                             25


<210>  830
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  830
ccaagucugg uacugaagca uuuau                                             25


<210>  831
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  831
cacccucagu ucauaggcug ucuua                                             25


<210>  832
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  832
caaauguaug auaagggcuu gguuu                                             25


<210>  833
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  833
ccucuacgua cuggcggcag auaaa                                             25


<210>  834
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  834
ggcggcagau aaaguagcau cuguu                                             25


<210>  835
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  835
cagugguuua uaaacaucac ggaua                                             25


<210>  836
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  836
gagcagauuu guacuuggaa ggaaa                                             25


<210>  837
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  837
gcugaaccag uagaagacaa uugca                                             25


<210>  838
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  838
ccaguagaag acaauugcau caacu                                             25


<210>  839
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  839
ugcaucaacu uuguggcaau gaaau                                             25


<210>  840
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  840
aaguucucuu cauugaccaa ggaaa                                             25


<210>  841
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  841
ccaaggaaau cggccucuau uugaa                                             25


<210>  842
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  842
ucggacagcu ugaacagaau guuua                                             25


<210>  843
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  843
cacuuggaga caaacuucac uuuaa                                             25


<210>  844
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  844
cacaaguuug cugauugcaa agcaa                                             25


<210>  845
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  845
aagugaagcc caauccgcca cauaa                                             25


<210>  846
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  846
ccaacccaag uauuaagagu guuau                                             25


<210>  847
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  847
aaaagucuug gaacagaucu g                                                 21


<210>  848
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  848
aagagggaua auacaaauga a                                                 21


<210>  849
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  849
acagaugaag uuaacaguga a                                                 21


<210>  850
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  850
cugcgagugu gauaauuuca a                                                 21


<210>  851
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  851
gggaaguuuc gagaguccua ccuuu                                             25


<210>  852
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  852
cacccagcau cuaucuggag agcaa                                             25


<210>  853
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  853
cagacccgaa gaaccaucac aucau                                             25


<210>  854
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  854
caacaucgac uugucugaug cuaag                                             25


<210>  855
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  855
ggccaccagg agaauaacaa cuucu                                             25


<210>  856
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  856
cccagaucgu gucacaucca uauga                                             25


<210>  857
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  857
cagaucgugu cacauccaua ugaca                                             25


<210>  858
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  858
ugucacaucc auaugacacu uggaa                                             25


<210>  859
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  859
cacuuggaau gugacagggc aggau                                             25


<210>  860
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  860
ggaaugugac agggcaggau gugau                                             25


<210>  861
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  861
caucccuacu ccagcacaac ucaca                                             25


<210>  862
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  862
ucccuacucc agcacaacuc acaaa                                             25


<210>  863
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  863
uccaaugcgc cuguccacau ugaug                                             25


<210>  864
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  864
ccaaugcgcc uguccacauu gaugu                                             25


<210>  865
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  865
ccucaccaaa uacccugaau ccaga                                             25


<210>  866
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  866
accguggagu uauuguucau gucau                                             25


<210>  867
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  867
cacagucauc cauucugacc gguuu                                             25


<210>  868
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  868
gagagugaac gucuggucca guauu                                             25


<210>  869
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  869
ggacggagug guucgaucau gauaa                                             25


<210>  870
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  870
accacugucu uggccuccuu gucaa                                             25


<210>  871
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  871
cagcgcauug cggcugaacu caaau                                             25


<210>  872
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  872
aauacaggau cugccuccag uugau                                             25


<210>  873
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  873
gaaauucucu uggccuucaa ccaaa                                             25


<210>  874
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  874
gagaugagag uauuguaggc cuuau                                             25


<210>  875
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  875
cccuucugau cauuaugcua uugag                                             25


<210>  876
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  876
gcuacuuccg ggaucggaaa cugua                                             25


<210>  877
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  877
ccgggaucgg aaacuguacu gcaaa                                             25


<210>  878
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  878
gaucggaaac uguacugcaa acaag                                             25


<210>  879
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  879
ggaaacugua cugcaaacaa gacua                                             25


<210>  880
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  880
gcaaacaaga cuaccaacag cucuu                                             25


<210>  881
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  881
gaugaugacc uagucugcca uauuu                                             25


<210>  882
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  882
gcaagaaguc uaguauucua guuca                                             25


<210>  883
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  883
caccacacaa cagccacuua guuua                                             25


<210>  884
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  884
ggguggcaac gaaacaccuu ugauu                                             25


<210>  885
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  885
cagauucuuc aggucaacaa cuaca                                             25


<210>  886
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  886
gagagaugag uugggaucaa gugga                                             25


<210>  887
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  887
gaguugggau caaguggauu gagga                                             25


<210>  888
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  888
ccucagacag guaucucuuc guuau                                             25


<210>  889
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  889
cguuaucaga agaguugcuu cauuu                                             25


<210>  890
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  890
caggcagcug uuaacagaua aguuu                                             25


<210>  891
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  891
ggcgcuuccu guuccggcgc cagga                                             25


<210>  892
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  892
gcuuccuguu ccggcgccag gagga                                             25


<210>  893
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  893
ccagauugaa gauacuccau cuucu                                             25


<210>  894
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  894
cgauacuaca gggucuccaa cugaa                                             25


<210>  895
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  895
caggaauacc caaauagcca gaacu                                             25


<210>  896
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  896
cgauccuauc cagacugauc ccuuu                                             25


<210>  897
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  897
ucuccacacu cagaguccuu uguuu                                             25


<210>  898
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  898
agaugagacg cuacaagcuc uuucu                                             25


<210>  899
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  899
ugagacgcua caagcucuuu cucau                                             25


<210>  900
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  900
cgcuacaagc ucuuucucau guucu                                             25


<210>  901
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  901
uacaagcucu uucucauguu cugua                                             25


<210>  902
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  902
caagcucuuu cucauguucu guaug                                             25


<210>  903
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  903
caguguuucu gggaaugcuc cagau                                             25


<210>  904
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  904
agacccugca gagaugacuu cugau                                             25


<210>  905
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  905
gaagaccaug uuguuggauu ggaau                                             25


<210>  906
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  906
ucgagaaagu gaguuugcaa gagaa                                             25


<210>  907
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  907
cagaugcuuc uaagccucca aagaa                                             25


<210>  908
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  908
gguguuauca aguguaacag caacu                                             25


<210>  909
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  909
aaaugaccua ugaauugaca gacaa                                             25


<210>  910
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  910
aaugaccuau gaauugacag acaau                                             25


<210>  911
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  911
gaccuaugaa uugacagaca auaua                                             25


<210>  912
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  912
caauauagcu gaguuugucu gucau                                             25


<210>  913
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  913
uagcugaguu ugucugucau uucuu                                             25


<210>  914
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  914
ccuccuaccg cagugcuuga cggga                                             25


<210>  915
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  915
ccgcagugcu ugacgggagg cggag                                             25


<210>  916
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  916
ggcugaggua guaguuugua caguu                                             25


<210>  917
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  917
gcugagguag uaguuuguac aguuu                                             25


<210>  918
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  918
gagguaguag uuuguacagu uugag                                             25


<210>  919
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  919
gguaguaguu uguacaguuu gaggg                                             25


<210>  920
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  920
ccuuggagua aaguagcagc acaua                                             25


<210>  921
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  921
uggaguaaag uagcagcaca uaaug                                             25


<210>  922
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  922
gaguaaagua gcagcacaua auggu                                             25


<210>  923
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  923
aguaaaguag cagcacauaa ugguu                                             25


<210>  924
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  924
ucagcagugc cuuagcagca cguaa                                             25


<210>  925
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  925
cagcagugcc uuagcagcac guaaa                                             25


<210>  926
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  926
agcagugccu uagcagcacg uaaau                                             25


<210>  927
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  927
gcagugccuu agcagcacgu aaaua                                             25


<210>  928
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  928
cagugccuua gcagcacgua aauau                                             25


<210>  929
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  929
uccacucuag cagcacguaa auauu                                             25


<210>  930
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  930
ccacucuagc agcacguaaa uauug                                             25


<210>  931
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  931
gcagcacgua aauauuggcg uagug                                             25


<210>  932
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  932
agcacguaaa uauuggcgua gugaa                                             25


<210>  933
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  933
gcacguaaau auuggcguag ugaaa                                             25


<210>  934
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  934
cguguucgac uuuccugaua auucu                                             25


<210>  935
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  935
uagcacagcu auauaugcug augaa                                             25


<210>  936
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  936
cacuucugga aaugaagcaa gugaa                                             25


<210>  937
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  937
ugaagcaagu gaaaucgaau cugua                                             25


<210>  938
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  938
caggcccauu agugaugacu cugaa                                             25


<210>  939
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  939
caguuugaag caaaugggua uuucu                                             25


<210>  940
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  940
agacacagaa cugucagcau guguu                                             25


<210>  941
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  941
ccacuacuau uaaaugacag cuguu                                             25


<210>  942
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  942
uaucugguuu cggacggacu guuaa                                             25


<210>  943
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  943
ggacggacug uuaaugacaa uuuga                                             25


<210>  944
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  944
caugaccgac uucauaccuu gguaa                                             25


<210>  945
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  945
ccgacuucau accuugguaa cugaa                                             25


<210>  946
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  946
ccagacauga cuugggacau caaau                                             25


<210>  947
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  947
cagacaugac uugggacauc aaaua                                             25


<210>  948
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  948
gacaugacuu gggacaucaa auaua                                             25


<210>  949
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  949
gcgucuguau uaaacaccgu gcuga                                             25


<210>  950
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  950
ggcggcuucc uaugcuaucu cucuu                                             25


<210>  951
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  951
ccucaguucc cauuucuccu uauaa                                             25


<210>  952
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  952
gcccuggaaa uaucuggaau cagaa                                             25


<210>  953
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  953
cggaauaaag uuguugggaa ucccu                                             25


<210>  954
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  954
cacucacauu aaguuaccaa gaaca                                             25


<210>  955
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  955
cagcuaccuu uagauucaga gaauu                                             25


<210>  956
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  956
ccaucuggau gaggagguaa auaaa                                             25


<210>  957
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  957
caggaaagug gaugauucag uauaa                                             25


<210>  958
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  958
caaaguucug cugucagcac uagaa                                             25


<210>  959
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  959
gaagggccug gaaccagaau ugucu                                             25


<210>  960
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  960
ccagaauugu cuggaacccu gaucu                                             25


<210>  961
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  961
gaauugucug gaacccugau cugua                                             25


<210>  962
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  962
ggaacccuga ucuguaccaa cuuua                                             25


<210>  963
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  963
cccuggucaa cauuggacga uuaga                                             25


<210>  964
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  964
ccaacaggaa cuaugaccuc gacua                                             25


<210>  965
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  965
ggaggagaca uggugaacca gaguu                                             25


<210>  966
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  966
gaggagacau ggugaaccag aguuu                                             25


<210>  967
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  967
ggagacaugg ugaaccagag uuuca                                             25


<210>  968
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  968
gagacauggu gaaccagagu uucau                                             25


<210>  969
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  969
gcugggagau gugacaccac acaau                                             25


<210>  970
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  970
caggucaucu uuccagucag cuaca                                             25


<210>  971
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  971
ggguggauca uucacagaau cagaa                                             25


<210>  972
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  972
ugacacuagg augucuggca ccuua                                             25


<210>  973
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  973
ccgaaggcua ggaauaggaa cuaaa                                             25


<210>  974
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  974
caagggaucu gugauuguau guuaa                                             25


<210>  975
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  975
caguugcaug cagagugagu uugaa                                             25


<210>  976
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  976
gggccaugcu uuauugacaa uauuu                                             25


<210>  977
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  977
ccacauuauu uagcucuccc uuauu                                             25


<210>  978
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  978
cccugacuga uagcuuucau cugua                                             25


<210>  979
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  979
acauggacau gagcauggac aucau                                             25


<210>  980
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  980
cauggacaug agcauggaca ucaua                                             25


<210>  981
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  981
uggacaugag cauggacauc auaaa                                             25


<210>  982
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  982
gaacuuccag auuauagaca augga                                             25


<210>  983
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  983
ccagauuaua gacaauggaa gauag                                             25


<210>  984
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  984
gguucggccu uaacauagau cgaug                                             25


<210>  985
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  985
ucggccuuaa cauagaucga ugguu                                             25


<210>  986
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  986
cggccuuaac auagaucgau gguug                                             25


<210>  987
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  987
ggccuuaaca uagaucgaug guuga                                             25


<210>  988
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  988
acauagaucg augguugaca aucca                                             25


<210>  989
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  989
gagcaguaua cagcaaacag caaua                                             25


<210>  990
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  990
caguauacag caaacagcaa uaguu                                             25


<210>  991
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  991
caaacagcaa uaguucgaca gagca                                             25


<210>  992
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  992
agguagucca agggcagcca uuaau                                             25


<210>  993
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  993
gaacacaggg uuugcagcaa auaca                                             25


<210>  994
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  994
cacagaggau cucugggaaa guuua                                             25


<210>  995
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  995
gaacagguag aagaugacag auuau                                             25


<210>  996
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  996
caguacagcu cugccaugcu ggaaa                                             25


<210>  997
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  997
cagcucugcc augcuggaaa guuua                                             25


<210>  998
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  998
gagcuggaau cauuagcacu guaga                                             25


<210>  999
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  999
ucggaccucu augccaugaa cuuca                                             25


<210>  1000
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1000
ucggaccucu augccaugaa cuuca                                             25


<210>  1001
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1001
gaaaggacau cacagguaaa cugaa                                             25


<210>  1002
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1002
ugccgagucu guucuggcuu auaaa                                             25


<210>  1003
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1003
cagguaaacu gaaggacccu gcgaa                                             25


<210>  1004
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1004
cgagucuguu cuggcuuaua aagaa                                             25


<210>  1005
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1005
cccuaaugaa gaagcaggcg gugaa                                             25


<210>  1006
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1006
cggagggaga uugagaucau gucau                                             25


<210>  1007
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1007
cagaucgucu cugccgugca cuauu                                             25


<210>  1008
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1008
ccucgccaga gauugucaau gggaa                                             25


<210>  1009
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1009
cagagauugu caaugggaag cccua                                             25


<210>  1010
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1010
caaacgccag aacccuacca uguuu                                             25


<210>  1011
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1011
acugugccca gugucagcuc cauua                                             25


<210>  1012
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1012
uccggaccaa agugcagcaa ccauu                                             25


<210>  1013
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1013
ggaccaaagu gcagcaacca uucaa                                             25


<210>  1014
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1014
cagugaucag gauagcugcc gacua                                             25


<210>  1015
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1015
ccugcugcug uuugccuccu agaaa                                             25


<210>  1016
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1016
ggagaugaac cucucugaaa cugcu                                             25


<210>  1017
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1017
caacuuugca caaaguuccu gcuuu                                             25


<210>  1018
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1018
uccugcuuug gacugagaug guuua                                             25


<210>  1019
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1019
gcaucguccu ggacuugccu cuuua                                             25


<210>  1020
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1020
ccggugugau ugaaggugga uuaaa                                             25


<210>  1021
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1021
cggugugauu gaagguggau uaaau                                             25


<210>  1022
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1022
gaagguggau uaaaugucac ucuca                                             25


<210>  1023
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1023
ucacucucac cauccggcua cuuau                                             25


<210>  1024
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1024
caucggaaag aaaggagaau caguu                                             25


<210>  1025
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1025
ucuaugcagu cauguauccu guguu                                             25


<210>  1026
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1026
cagacacuga gagccgcuuu cauca                                             25


<210>  1027
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1027
ccuucuucgu auggcagcug augau                                             25


<210>  1028
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1028
cagagccaga auuccaagac cuaaa                                             25


<210>  1029
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1029
ccagaauucc aagaccuaaa cgaaa                                             25


<210>  1030
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1030
ccacuccaau cgagguucca uguau                                             25


<210>  1031
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1031
cacuccaauc gagguuccau guaug                                             25


<210>  1032
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1032
ccauguauga uggcuuggcu gacaa                                             25


<210>  1033
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1033
gcagcgacau cugcuucaug cagaa                                             25


<210>  1034
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1034
ucuuguuccg caaagggcca cuagu                                             25


<210>  1035
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1035
ccggugaaca caguguucuu gaacu                                             25


<210>  1036
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1036
aggucugguc ugaggagcua uucaa                                             25


<210>  1037
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1037
aggagcuauu caagcuggcu augaa                                             25


<210>  1038
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1038
ccgucaagaa cauccugaag auguu                                             25


<210>  1039
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1039
cagccacuga gugccuacuu cauca                                             25


<210>  1040
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1040
cacuagaagu augugggcag augau                                             25


<210>  1041
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1041
cagcauugau gaggcuuacg uagau                                             25


<210>  1042
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1042
ccuaucucgg cagacuuguu gccaa                                             25


<210>  1043
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1043
cagccauaga gagggagacu gguuu                                             25


<210>  1044
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1044
caguuaaacc caggcaacua cccaa                                             25


<210>  1045
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1045
agacaccauc cuuggugccu gugaa                                             25


<210>  1046
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1046
cagagaagaa auacaagcca cucaa                                             25


<210>  1047
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1047
caagccacuc aacacaacac cuaau                                             25


<210>  1048
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1048
ccaaagagau caaagugaag aucau                                             25


<210>  1049
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1049
ccugggcuuu cuggaugcuc uuaau                                             25


<210>  1050
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1050
caagacgagc aagacacaca cagau                                             25


<210>  1051
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1051
gagcaagaca cacacagaua cugaa                                             25


<210>  1052
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1052
ccagugcucu caugcugcug uuuca                                             25


<210>  1053
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1053
gcugcuguuu cagccuacaa gcaga                                             25


<210>  1054
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1054
caagguggug gucaaagcuc cugau                                             25


<210>  1055
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1055
uccgacuuug auagauuucu a                                                 21


<210>  1056
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1056
ccgacugaaa cuggaacccu u                                                 21


<210>  1057
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1057
ccugugauuu augccaauaa a                                                 21


<210>  1058
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1058
cugcuggaac ugaacgcugu a                                                 21


<210>  1059
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1059
uacacugagg uuugaauuca u                                                 21


<210>  1060
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1060
gaggcugauc uggagaagaa guuca                                             25


<210>  1061
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1061
cacacaccau gaaucuacua aagca                                             25


<210>  1062
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1062
cagaacccaa uggaauccug cauau                                             25


<210>  1063
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1063
ggacaugcca aagccaucaa uuuca                                             25


<210>  1064
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1064
ccuguagccu aucgagucaa guaua                                             25


<210>  1065
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1065
uggaucgggu gaagguacug guguu                                             25


<210>  1066
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1066
ggagacucag guguugggaa aucuu                                             25


<210>  1067
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1067
gcugcucagu ggaugucaga guuca                                             25


<210>  1068
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1068
caguggaugu cagaguucau gauua                                             25


<210>  1069
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1069
cccagaagag aagaccuacu acaua                                             25


<210>  1070
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1070
caagagcugu gugaccgucu gagua                                             25


<210>  1071
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1071
uggagcuuau gaaggugacu ggucu                                             25


<210>  1072
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1072
gaggugucca ugaacuucua uguau                                             25


<210>  1073
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1073
gaaggagcug ugguguacau ugaca                                             25


<210>  1074
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1074
gggaacucac cugugaugaa guucu                                             25


<210>  1075
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1075
cgcugcccuc ucguagagau guuua                                             25


<210>  1076
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1076
ugcccucucg uagagauguu uauuu                                             25


<210>  1077
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1077
cccucucgua gagauguuua uuugu                                             25


<210>  1078
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1078
cccaagagau gauggguauu cuacu                                             25


<210>  1079
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1079
ggguauucua cuaaagacag cuauu                                             25


<210>  1080
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1080
ccagaucuca gagacaucga gcuga                                             25


<210>  1081
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1081
cagaucucag agacaucgag cugaa                                             25


<210>  1082
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1082
ggcuagagac caaacugcac auccu                                             25


<210>  1083
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1083
acguaaggcu caugcgucaa uugcu                                             25


<210>  1084
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1084
ggcucaugcg ucaauugcuc cucau                                             25


<210>  1085
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1085
agaguugacc uugcuuggca guuaa                                             25


<210>  1086
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1086
gaguugaccu ugcuuggcag uuaau                                             25


<210>  1087
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1087
ggaagguaau cauuguggau gcuga                                             25


<210>  1088
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1088
gauguauggu augagagcaa guuug                                             25


<210>  1089
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1089
ugacugugac aaggaggcuu gcuua                                             25


<210>  1090
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1090
cagcccuccu uugaagugau cucag                                             25


<210>  1091
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1091
aguccagaaa cuacuugccc auucu                                             25


<210>  1092
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1092
ccagaaacua cuugcccauu cuaaa                                             25


<210>  1093
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1093
cagaaacuac uugcccauuc uaaau                                             25


<210>  1094
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1094
caucagacag cacucugcau ggcuu                                             25


<210>  1095
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1095
cauggcaugu uaaaguaccu ccgau                                             25


<210>  1096
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1096
uccgaugugg cuggaagcuu guauu                                             25


<210>  1097
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1097
aggcccaaau gaauaaacaa guguu                                             25


<210>  1098
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1098
ugguugaugu aagucagccu gcaua                                             25


<210>  1099
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1099
ccagaaagaa cagauggaaa cuaag                                             25


<210>  1100
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1100
ccgcaugcga aucuuugcgc cuaau                                             25


<210>  1101
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1101
gcaugcgaau cuuugcgccu aauca                                             25


<210>  1102
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1102
caugcgaauc uuugcgccua aucau                                             25


<210>  1103
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1103
caagucccgc uucugguacu uugua                                             25


<210>  1104
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1104
cccgcuucug guacuuugua ucuca                                             25


<210>  1105
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1105
gcgguaaugc ugguggucug cauca                                             25


<210>  1106
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1106
caucaccacc ggaucaacuu cgaca                                             25


<210>  1107
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1107
caggcuacuu ugggaaaguu gguau                                             25


<210>  1108
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1108
acagacacgg gugaaugcug cuaaa                                             25


<210>  1109
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1109
gauguggugc gaucgggcua cuaca                                             25


<210>  1110
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1110
cccuacaaag acuucagagu agaua                                             25


<210>  1111
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1111
ccuacaaaga cuucagagua gauau                                             25


<210>  1112
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1112
caaagacuuc agaguagaua ucucu                                             25


<210>  1113
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1113
ccuccugcgc uauugguaca aauaa                                             25


<210>  1114
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1114
gcgcuauugg uacaaauaag ccuga                                             25


<210>  1115
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1115
cccgaucacg aagauaugaa ucucu                                             25


<210>  1116
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1116
ccgaucacga agauaugaau cucuu                                             25


<210>  1117
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1117
cgaucacgaa gauaugaauc ucuua                                             25


<210>  1118
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1118
ccggaccuuc aagacugucu uugcu                                             25


<210>  1119
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1119
gaugaaugca agaggcguuu cuaua                                             25


<210>  1120
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1120
cagguaccug ugaaccaagu guuug                                             25


<210>  1121
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1121
accaaguguu ugggcaggau gagau                                             25


<210>  1122
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1122
cgcacugaga ucaacaagaa gauuu                                             25


<210>  1123
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1123
agauacuacu caaguuacag uauau                                             25


<210>  1124
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1124
caaguuacag uauaugauca cuaau                                             25


<210>  1125
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1125
caggagcucu gauauauauc uggua                                             25


<210>  1126
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1126
ggagcucuga uauauaucug guaca                                             25


<210>  1127
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1127
gcucugauau auaucuggua caugu                                             25


<210>  1128
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1128
ccaagaaagu cgggaucguc gguaa                                             25


<210>  1129
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1129
caagaaaguc gggaucgucg guaaa                                             25


<210>  1130
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1130
cgucgguaaa uacgggaccc gcuau                                             25


<210>  1131
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1131
aaauugaaau cagccagcac gccaa                                             25


<210>  1132
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1132
gaaaucagcc agcacgccaa guaca                                             25


<210>  1133
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1133
ccacugauau cgguguacuc cgaaa                                             25


<210>  1134
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1134
cagacagccc uaugcuguca gugaa                                             25


<210>  1135
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1135
gcccuaccag cacuggucau gucua                                             25


<210>  1136
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1136
uggucauguc uaaaggucau cguau                                             25


<210>  1137
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1137
ggaaguuccu gaacuuccuu uggua                                             25


<210>  1138
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1138
ccgaaaggaa agaaggccaa gggaa                                             25


<210>  1139
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1139
cgugaagaag caggaggcua agaaa                                             25


<210>  1140
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1140
cccgcuauau cagguugcag cggca                                             25


<210>  1141
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1141
cagcggcaga gagccauccu cuaua                                             25


<210>  1142
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1142
gagccauccu cuauaagcgg cugaa                                             25


<210>  1143
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1143
uggaacgugu gaucaccauu a                                                 21


<210>  1144
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1144
aagaagauuc gggcccauag a                                                 21


<210>  1145
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1145
cuggacaaca agcuccguga a                                                 21


<210>  1146
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1146
acgccaguac aagaucccag a                                                 21


<210>  1147
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1147
aaguugucuu cauuuaguuu gcuuu                                             25


<210>  1148
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1148
uacuccagau cagaauaccu gggau                                             25


<210>  1149
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1149
acuccagauc agaauaccug ggauu                                             25


<210>  1150
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1150
ccagaucaga auaccuggga uugca                                             25


<210>  1151
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1151
cagaucagaa uaccugggau ugcau                                             25


<210>  1152
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1152
uggcuguagu accucugcug uuguu                                             25


<210>  1153
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1153
gccacaacgu ccgacugcac ucaca                                             25


<210>  1154
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1154
accucugugg augacagcaa caguu                                             25


<210>  1155
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1155
uggaugacug gacagugcuc uguaa                                             25


<210>  1156
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1156
gagagauggu gaggugcggu ucaaa                                             25


<210>  1157
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1157
gggaggagau cagaggacca aguuu                                             25


<210>  1158
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1158
ccaaauggcu aagugaaccu auguu                                             25


<210>  1159
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1159
caucccagau gguacugauc caaau                                             25


<210>  1160
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1160
gaucagccgu guguguguau cauuu                                             25


<210>  1161
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1161
cguauuggca cugacuacaa guaua                                             25


<210>  1162
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1162
cggagaccca ucacuggcau gauua                                             25


<210>  1163
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1163
caucacuggc augauuacca guaua                                             25


<210>  1164
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1164
ccuaccaccu ccuuugccau cuuua                                             25


<210>  1165
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1165
gcucagacag uugcuggcuu ccuua                                             25


<210>  1166
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1166
ggacagugag caggcuguaa uugaa                                             25


<210>  1167
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1167
gcugacuugu cagugaauau guaua                                             25


<210>  1168
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1168
cacucaaugg gauaugacag ccuaa                                             25


<210>  1169
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1169
gcccucauua augcugucua uuuca                                             25


<210>  1170
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1170
ccaaguccua gaaauaccau augaa                                             25


<210>  1171
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1171
uggcugugcu guauccucaa guuau                                             25


<210>  1172
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1172
gggccuggau gagaagguua gugaa                                             25


<210>  1173
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1173
aaggcuaugg cuuuguggaa uucuu                                             25


<210>  1174
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1174
ggcuauggcu uuguggaauu cuuga                                             25


<210>  1175
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1175
gaggaagaug cugacuaugc cauua                                             25


<210>  1176
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1176
ugaacaugau caaacucuau gggaa                                             25


<210>  1177
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1177
aacccuagau cucgaaaugc a                                                 21


<210>  1178
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1178
aagcugaucc aucaugaugu a                                                 21


<210>  1179
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1179
gagcuagaug gaagaacacu a                                                 21


<210>  1180
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1180
cucguagucg aucuagguca a                                                 21


<210>  1181
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1181
cucgauggga ucaaagcacu u                                                 21


<210>  1182
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1182
aggacucaau gcauugacca a                                                 21


<210>  1183
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1183
cgcguguacu ucaauaaggg a                                                 21


<210>  1184
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1184
ucggcgaacg cugcgaaaca a                                                 21


<210>  1185
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1185
ccaagaaagc augucgccua cugua                                             25


<210>  1186
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1186
ccacagaacu cacucagacu guguu                                             25


<210>  1187
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1187
caguguguga ugaacuguac auaua                                             25


<210>  1188
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1188
gguguacuuc agaccagcuu cauau                                             25


<210>  1189
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1189
agguacuggg cauacuucca uucaa                                             25


<210>  1190
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1190
cgggacuugg gagucaagau aucug                                             25


<210>  1191
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1191
ccacgaucuu ugaugugggu gagaa                                             25


<210>  1192
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1192
cacgaucuuu gaugugggug agaau                                             25


<210>  1193
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1193
gaucuuugau gugggugaga aucua                                             25


<210>  1194
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1194
gcaucguugg uggcuucacu cagau                                             25


<210>  1195
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1195
cauccaggua cuacuuccuu uggaa                                             25


<210>  1196
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1196
caguggaauc cuugggcuuu cuuau                                             25


<210>  1197
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1197
gacugccaau gaaggagggu cuuua                                             25


<210>  1198
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1198
gccaaugaag gagggucuuu auuau                                             25


<210>  1199
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1199
gcuaccucuu cauagugaaa uauga                                             25


<210>  1200
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1200
caagaggcug cugcucuacu ucaua                                             25


<210>  1201
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1201
cggaggcauu ugguuucaac ccucu                                             25


<210>  1202
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1202
gaagauuauu augucuccaa gucug                                             25


<210>  1203
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1203
cagagaagau cuugaagauu cuucu                                             25


<210>  1204
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1204
caucaucaug gacacagcca uuaug                                             25


<210>  1205
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1205
gaggcauaga gacagugcua cuaau                                             25


<210>  1206
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1206
ugcaggacgu uauuauucau cugaa                                             25


<210>  1207
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1207
ucagcaacau uuaucugccc uugaa                                             25


<210>  1208
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1208
cagcaacauu uaucugcccu ugaaa                                             25


<210>  1209
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1209
ccagucugua gauauugcaa cuuug                                             25


<210>  1210
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1210
gaaugggcac uguugaucau ggugu                                             25


<210>  1211
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1211
ugggcacugu ugaucauggu gucca                                             25


<210>  1212
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1212
gggcacuguu gaucauggug uccaa                                             25


<210>  1213
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1213
uggcuaaauu gagacagguu augcu                                             25


<210>  1214
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1214
ugagacaggu uaugcuucca ucaca                                             25


<210>  1215
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1215
ccuguagccu gcacaucguu ggaaa                                             25


<210>  1216
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1216
ugcacaucgu uggaaacgcc ucaua                                             25


<210>  1217
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1217
gcacaucguu ggaaacgccu cauag                                             25


<210>  1218
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1218
ggaaacgccu cauagaguaa cucug                                             25


<210>  1219
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1219
acgccucaua gaguaacucu guggu                                             25


<210>  1220
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1220
gcacauuuca uugaccugcu uucuu                                             25


<210>  1221
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1221
cacauuucau ugaccugcuu ucuuu                                             25


<210>  1222
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1222
gaguaguguu auuucuuaug ugcua                                             25


<210>  1223
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1223
uauuucuuau gugcuauaca aauaa                                             25


<210>  1224
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1224
gcuauacaaa uaauugaagg cuaau                                             25


<210>  1225
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1225
ucgaggcuag agucacgcuu gggua                                             25


<210>  1226
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1226
gagucacgcu uggguaucgg cuauu                                             25


<210>  1227
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1227
gcuauugccu gagugugcua gaguc                                             25


<210>  1228
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1228
gagugugcua gaguccucga agagu                                             25


<210>  1229
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1229
ccucgaagag uaacugcuga ccuua                                             25


<210>  1230
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1230
ugcaguuucu cauuugcugu ggaca                                             25


<210>  1231
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1231
ucauuugcug uggacaugac cauaa                                             25


<210>  1232
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1232
cauuugcugu ggacaugacc auaaa                                             25


<210>  1233
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1233
ugcuacuuug cuagcaauca gcuua                                             25


<210>  1234
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1234
gcuacuuugc uagcaaucag cuuau                                             25


<210>  1235
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1235
ccuccuacaa aggcgugucu guggu                                             25


<210>  1236
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1236
aggcgugucu gugguucccu gucuu                                             25


<210>  1237
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1237
ggcgugucug ugguucccug ucuuu                                             25


<210>  1238
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1238
ugguucccug ucuuuggaca cguaa                                             25


<210>  1239
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1239
cccugucuuu ggacacguaa gaauu                                             25


<210>  1240
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1240
caacccagaa cucauuguuc aguau                                             25


<210>  1241
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1241
cccagaacuc auuguucagu augag                                             25


<210>  1242
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1242
ccagaacuca uuguucagua ugagu                                             25


<210>  1243
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1243
cagaacucau uguucaguau gaguu                                             25


<210>  1244
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1244
agaacucauu guucaguaug aguuu                                             25


<210>  1245
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1245
ccugacacaa cucuuguccu ggugu                                             25


<210>  1246
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1246
gacacaacuc uuguccuggu gugcu                                             25


<210>  1247
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1247
acucuugucc uggugugcua gagua                                             25


<210>  1248
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1248
ccuggugugc uagaguacuc gaaga                                             25


<210>  1249
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1249
ggugugcuag aguacucgaa gagaa                                             25


<210>  1250
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1250
acccguuagc cuggcuguag cuaau                                             25


<210>  1251
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1251
uaauggguuc cauuccggug caaua                                             25


<210>  1252
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1252
gguuccauuc cggugcaaua gcauu                                             25


<210>  1253
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1253
ccauuccggu gcaauagcau uucca                                             25


<210>  1254
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1254
cggugcaaua gcauuuccag cgaca                                             25


<210>  1255
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1255
gcacacuauu aaagcucagg gugga                                             25


<210>  1256
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1256
aaagcucagg guggaggcca gucuu                                             25


<210>  1257
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1257
ggaggccagu cuuggcucau gaacu                                             25


<210>  1258
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1258
gaggccaguc uuggcucaug aacuu                                             25


<210>  1259
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1259
ggccagucuu ggcucaugaa cuucu                                             25


<210>  1260
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1260
gcacauuguu agagcuugga guuga                                             25


<210>  1261
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1261
cacauuguua gagcuuggag uugag                                             25


<210>  1262
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1262
gagcuuggag uugaggcuac ugacu                                             25


<210>  1263
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1263
acuggccgau gaacucgcaa gugua                                             25


<210>  1264
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1264
gcccaaugag uggaguuuga uagua                                             25


<210>  1265
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1265
ggucaaucug cagcgcuaga gcaug                                             25


<210>  1266
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1266
cagcgcuaga gcaugugcuu gcgca                                             25


<210>  1267
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1267
gcgcuagagc augugcuugc gcaua                                             25


<210>  1268
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1268
cgcuagagca ugugcuugcg cauaa                                             25


<210>  1269
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1269
gcuagagcau gugcuugcgc auaac                                             25


<210>  1270
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1270
cacugcaugg uaucugcacu cagca                                             25


<210>  1271
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1271
caugguaucu gcacucagca guuua                                             25


<210>  1272
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1272
caguuuacac cugcuagggu guuca                                             25


<210>  1273
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1273
caccugcuag gguguucaaa gguca                                             25


<210>  1274
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1274
caaaggucag ugcuauagaa auuca                                             25


<210>  1275
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1275
ccugugguug cuggaugcug uugug                                             25


<210>  1276
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1276
ugcuggaugc uguugugcau ggaca                                             25


<210>  1277
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1277
gaugcuguug ugcauggaca gcucu                                             25


<210>  1278
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1278
ccaguggauu cgaugggcca uagca                                             25


<210>  1279
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1279
caguggauuc gaugggccau agcaa                                             25


<210>  1280
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1280
caaugauguc guaauuugcg ucuua                                             25


<210>  1281
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1281
gaugucguaa uuugcgucuu acucu                                             25


<210>  1282
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1282
cguaauuugc gucuuacucu guucu                                             25


<210>  1283
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1283
gcgucuuacu cuguucucag cgaca                                             25


<210>  1284
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1284
ucuuacucug uucucagcga caguu                                             25


<210>  1285
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1285
caguagugau gaaauuccac uucau                                             25


<210>  1286
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1286
aguagugaug aaauuccacu ucauu                                             25


<210>  1287
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1287
gaaauuccac uucauugguc cgugu                                             25


<210>  1288
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1288
aaauuccacu ucauuggucc guguu                                             25


<210>  1289
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1289
aauuccacuu cauugguccg uguuu                                             25


<210>  1290
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1290
gagauuccac uuaauugguc cgugu                                             25


<210>  1291
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1291
agauuccacu uaauuggucc guguu                                             25


<210>  1292
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1292
gauuccacuu aauugguccg uguuu                                             25


<210>  1293
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1293
ccacuuaauu gguccguguu ucuga                                             25


<210>  1294
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1294
cacuuaauug guccguguuu cugaa                                             25


<210>  1295
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1295
ugagauucca cuuaaggucc guguu                                             25


<210>  1296
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1296
gagauuccac uuaagguccg uguuu                                             25


<210>  1297
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1297
gauuccacuu aagguccgug uuucu                                             25


<210>  1298
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1298
uccacuuaag guccguguuu cugaa                                             25


<210>  1299
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1299
acuuaagguc cguguuucug aaaca                                             25


<210>  1300
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1300
gaauauuugc uaucugagag auggu                                             25


<210>  1301
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1301
uauuugcuau cugagagaug gugau                                             25


<210>  1302
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1302
ugcuaucuga gagaugguga ugaca                                             25


<210>  1303
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1303
gcuaucugag agauggugau gacau                                             25


<210>  1304
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1304
uaucugagag auggugauga cauuu                                             25


<210>  1305
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1305
uggucuucag augcccacgu gggca                                             25


<210>  1306
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1306
agaugcccac gugggcacug cugag                                             25


<210>  1307
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1307
gaugcccacg ugggcacugc ugaga                                             25


<210>  1308
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1308
ugcccacgug ggcacugcug agaaa                                             25


<210>  1309
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1309
cacgugggca cugcugagaa agcca                                             25


<210>  1310
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1310
gcaaugaugu gaaucucuca cugaa                                             25


<210>  1311
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1311
caaugaugug aaucucucac ugaau                                             25


<210>  1312
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1312
aaugauguga aucucucacu gaauu                                             25


<210>  1313
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1313
ugaugugaau cucucacuga auuca                                             25


<210>  1314
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1314
gaugugaauc ucucacugaa uucaa                                             25


<210>  1315
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1315
ucuuggccug aaauuacugu gaaga                                             25


<210>  1316
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1316
uggccugaaa uuacugugaa gagua                                             25


<210>  1317
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1317
ggccugaaau uacugugaag aguaa                                             25


<210>  1318
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1318
gccugaaauu acugugaaga guaaa                                             25


<210>  1319
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1319
ugccaaugau gguuaagaau uucuu                                             25


<210>  1320
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1320
ccaaugaugg uuaagaauuu cuuca                                             25


<210>  1321
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1321
gaugguuaag aauuucuuca ccuga                                             25


<210>  1322
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1322
ugguuaagaa uuucuucacc ugaau                                             25


<210>  1323
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1323
gguuaagaau uucuucaccu gaaua                                             25


<210>  1324
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1324
aagacuauac uuucagggau cauuu                                             25


<210>  1325
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1325
acuauacuuu cagggaucau uucua                                             25


<210>  1326
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1326
cagggaucau uucuauagug uguua                                             25


<210>  1327
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1327
gggaucauuu cuauagugug uuacu                                             25


<210>  1328
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1328
gaaguuucuc ugaacgugua gagca                                             25


<210>  1329
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1329
gaugaugaac uuauugacgg gcgga                                             25


<210>  1330
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1330
gaugaacuua uugacgggcg gacag                                             25


<210>  1331
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1331
ugaacuuauu gacgggcgga cagaa                                             25


<210>  1332
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1332
gaacuuauug acgggcggac agaaa                                             25


<210>  1333
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1333
gacgggcgga cagaaacugu gugcu                                             25


<210>  1334
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1334
ccuggaugau gauaagcaaa ugcug                                             25


<210>  1335
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1335
ugaugauaag caaaugcuga cugaa                                             25


<210>  1336
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1336
uaagcaaaug cugacugaac augaa                                             25


<210>  1337
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1337
aaugcugacu gaacaugaag gucuu                                             25


<210>  1338
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1338
gcugacugaa caugaagguc uuaau                                             25


<210>  1339
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1339
accaaugaug uaaugauucu gccaa                                             25


<210>  1340
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1340
ccaaugaugu aaugauucug ccaaa                                             25


<210>  1341
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1341
caaugaugua augauucugc caaau                                             25


<210>  1342
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1342
ugauguaaug auucugccaa augaa                                             25


<210>  1343
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1343
gauguaauga uucugccaaa ugaaa                                             25


<210>  1344
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1344
ucagaugaug aauuuaacug uucaa                                             25


<210>  1345
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1345
gaugaugaau uuaacuguuc aacug                                             25


<210>  1346
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1346
ugaugaauuu aacuguucaa cugcu                                             25


<210>  1347
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1347
ugaauuuaac uguucaacug cugaa                                             25


<210>  1348
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1348
uaacuguuca acugcugaau gauaa                                             25


<210>  1349
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1349
cagugaugac uuucuuagga caccu                                             25


<210>  1350
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1350
agugaugacu uucuuaggac accuu                                             25


<210>  1351
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1351
ugaugacuuu cuuaggacac cuuug                                             25


<210>  1352
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1352
ugacuuucuu aggacaccuu uggau                                             25


<210>  1353
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1353
gacuuucuua ggacaccuuu ggauu                                             25


<210>  1354
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1354
gauguuauga ugaugggcga aaugu                                             25


<210>  1355
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1355
gaugggcgaa auguucaacu gcucu                                             25


<210>  1356
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1356
gggcgaaaug uucaacugcu cugaa                                             25


<210>  1357
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1357
ggcgaaaugu ucaacugcuc ugaag                                             25


<210>  1358
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1358
gcgaaauguu caacugcucu gaagg                                             25


<210>  1359
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1359
agucugugau gaauugcuuu gacuu                                             25


<210>  1360
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1360
ucugugauga auugcuuuga cuucu                                             25


<210>  1361
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1361
gcuuugacuu cugacaccuc guaug                                             25


<210>  1362
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1362
aacugcacgu gcagucugau uauuu                                             25


<210>  1363
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1363
acugcacgug cagucugauu auuua                                             25


<210>  1364
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1364
ugaauuugau ugcauugauc gucug                                             25


<210>  1365
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1365
gauugcauug aucgucugac augau                                             25


<210>  1366
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1366
ugcauugauc gucugacaug auaau                                             25


<210>  1367
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1367
ugaucgucug acaugauaau guauu                                             25


<210>  1368
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1368
gaucgucuga caugauaaug uauuu                                             25


<210>  1369
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1369
gccucugaug aagccugugu uggua                                             25


<210>  1370
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1370
gaugaagccu guguugguag ggaca                                             25


<210>  1371
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1371
gaagccugug uugguaggga caucu                                             25


<210>  1372
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1372
gccuguguug guagggacau cugac                                             25


<210>  1373
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1373
ccuguguugg uagggacauc ugaca                                             25


<210>  1374
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1374
ccugugaugc uuuaagagua gugga                                             25


<210>  1375
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1375
gaugcuuuaa gaguagugga cagaa                                             25


<210>  1376
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1376
gaguagugga cagaagggau uucug                                             25


<210>  1377
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1377
uaguggacag aagggauuuc ugaaa                                             25


<210>  1378
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1378
ggacagaagg gauuucugaa auucu                                             25


<210>  1379
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1379
ugccacaaug augacaguuu auuug                                             25


<210>  1380
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1380
ccacaaugau gacaguuuau uugcu                                             25


<210>  1381
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1381
cacaaugaug acaguuuauu ugcua                                             25


<210>  1382
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1382
ugaugacagu uuauuugcua cucuu                                             25


<210>  1383
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1383
gacaguuuau uugcuacucu ugagu                                             25


<210>  1384
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1384
cagauacuau gaugguugca uaguu                                             25


<210>  1385
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1385
gauacuauga ugguugcaua guuca                                             25


<210>  1386
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1386
acuaugaugg uugcauaguu cagca                                             25


<210>  1387
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1387
gaugguugca uaguucagca gauuu                                             25


<210>  1388
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1388
ugguugcaua guucagcaga uuuaa                                             25


<210>  1389
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1389
uguaaugaug uugaucaaau gucug                                             25


<210>  1390
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1390
ugauguugau caaaugucug accug                                             25


<210>  1391
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1391
gauguugauc aaaugucuga ccuga                                             25


<210>  1392
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1392
uguugaucaa augucugacc ugaaa                                             25


<210>  1393
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1393
gaucaaaugu cugaccugaa augag                                             25


<210>  1394
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1394
acaaugauga uaacauaguu cagca                                             25


<210>  1395
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1395
gaugauaaca uaguucagca gacua                                             25


<210>  1396
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1396
cauaguucag cagacuaacg cugau                                             25


<210>  1397
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1397
cagacuaacg cugaugagca auauu                                             25


<210>  1398
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1398
agacuaacgc ugaugagcaa uauua                                             25


<210>  1399
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1399
caugaugauc ucaauccaac uugaa                                             25


<210>  1400
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1400
ugaugaucuc aauccaacuu gaacu                                             25


<210>  1401
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1401
gaucucaauc caacuugaac ucucu                                             25


<210>  1402
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1402
ucaauccaac uugaacucuc ucacu                                             25


<210>  1403
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1403
caauccaacu ugaacucucu cacug                                             25


<210>  1404
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1404
gcuguucguu gaugaggcuc agagu                                             25


<210>  1405
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1405
gagcgcuggg uacagcgccc gaauc                                             25


<210>  1406
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1406
uacagcgccc gaaucggaca gugua                                             25


<210>  1407
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1407
ccgaaucgga caguguagaa ccauu                                             25


<210>  1408
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1408
ucggacagug uagaaccauu cucua                                             25


<210>  1409
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1409
gcuguucagu gaugaggccu ggaau                                             25


<210>  1410
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1410
gcccgagaca gacugcggaa ccguu                                             25


<210>  1411
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1411
gacagacugc ggaaccguuc cuugu                                             25


<210>  1412
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1412
acagacugcg gaaccguucc uuguu                                             25


<210>  1413
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1413
cagacugcgg aaccguuccu uguug                                             25


<210>  1414
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1414
ugauaauuac gacauggauu gugua                                             25


<210>  1415
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1415
ggauugugua uauucuugcu cggaa                                             25


<210>  1416
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1416
gauuguguau auucuugcuc ggaaa                                             25


<210>  1417
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1417
uguggaaagu gaggcugugu cugua                                             25


<210>  1418
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1418
caggguguaa gggagaagau gucca                                             25


<210>  1419
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1419
aaugauucag caugcuguau uuaaa                                             25


<210>  1420
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1420
caacaacaug uucaaagcua gcaua                                             25


<210>  1421
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1421
caacauguuc aaagcuagca uauua                                             25


<210>  1422
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1422
gaggaaaggu uggaagaccu guuua                                             25


<210>  1423
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1423
ggauccuguc aucauugcuu cugaa                                             25


<210>  1424
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1424
aagauggguu ugaacauaaa gaguu                                             25


<210>  1425
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1425
gggccuuccu guaccggcuc uggaa                                             25


<210>  1426
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1426
cgcagcugcg cugucgucau gucug                                             25


<210>  1427
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1427
cagccaucac uucauugaca guuca                                             25


<210>  1428
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1428
ucacuccaua uauucagcau cguca                                             25


<210>  1429
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1429
ggguggaggc caagucucau gcauu                                             25


<210>  1430
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1430
ggguuaauuu aacucagccu cugug                                             25


<210>  1431
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1431
cagguugcca gagacagaac ccuca                                             25


<210>  1432
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1432
cagaacccuc agcuuagcau gggaa                                             25


<210>  1433
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1433
gcaugggaag uagcuucccu guuga                                             25


<210>  1434
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1434
gaagaagaag cugacuggau cuaca                                             25


<210>  1435
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1435
cgagggcagc cagccagcag cuuca                                             25


<210>  1436
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1436
gagcugaaag augucuacaa ccauu                                             25


<210>  1437
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1437
cacuaugccu auuccuucaa guauu                                             25


<210>  1438
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1438
ccacugacau cagcauagau uugaa                                             25


<210>  1439
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1439
gaggcaccuu uggagggaau auuau                                             25


<210>  1440
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1440
gagggaauau uauccagcau ucaau                                             25


<210>  1441
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1441
gcaaccaaga uaaagaacua uuaua                                             25


<210>  1442
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1442
gaacaagguu cugucaucaa cugaa                                             25


<210>  1443
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1443
ccacuggacg cugucucaag auuua                                             25


<210>  1444
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1444
ggauaaauca ggaauagauu cucuu                                             25


<210>  1445
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1445
caucugaugc uguggaacuu gcaaa                                             25


<210>  1446
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1446
aaaucgaagu gauaacucuu cugau                                             25


<210>  1447
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1447
gauaacucuu cugauagcag cuuau                                             25


<210>  1448
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1448
acucuucuga uagcagcuua uuuaa                                             25


<210>  1449
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1449
gaagaacuau uuguaaacaa caauu                                             25


<210>  1450
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1450
gaacuauuug uaaacaacaa uuacu                                             25


<210>  1451
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1451
ggaagguugu uggccaacaa gauuu                                             25


<210>  1452
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1452
caugcacgaa cuguuagcac cuaua                                             25


<210>  1453
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1453
ccuaugcagu guucucacaa cuuau                                             25


<210>  1454
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1454
caccugauuc caaacugaac uuaca                                             25


<210>  1455
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1455
cgacgccuuu cagaagucau cuaug                                             25


<210>  1456
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1456
cagcaucaag gaggaggagu gugau                                             25


<210>  1457
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1457
caaggaggag gagugugauu cugag                                             25


<210>  1458
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1458
ccagugaaga cguugggcuu cuuua                                             25


<210>  1459
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1459
ccuucaagac cuuauugacu cucua                                             25


<210>  1460
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1460
cccugugaag gugagggaca auaau                                             25


<210>  1461
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1461
caacaggauu uggucuacaa agaaa                                             25


<210>  1462
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1462
aaacgagcag cuguggaaau uuaaa                                             25


<210>  1463
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1463
ccaccuuuau gaagaggcug gugaa                                             25


<210>  1464
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1464
uuggugcaac ccuaauugga a                                                 21


<210>  1465
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1465
cugguugucc uggauguuug a                                                 21


<210>  1466
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1466
uaggguggaa ugugauguuc a                                                 21


<210>  1467
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1467
gagacgugua gcaaugaaca a                                                 21


<210>  1468
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1468
caagaucauu gaguggucuu aucuu                                             25


<210>  1469
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1469
cccaaauggu guaacagacu uuauu                                             25


<210>  1470
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1470
ccaaauggug uaacagacuu uauua                                             25


<210>  1471
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1471
cagacauaga uauuauccua cuuaa                                             25


<210>  1472
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1472
cagauucagu aggacaucau uuaaa                                             25


<210>  1473
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1473
cacuccaagu acgggugcac guuca                                             25


<210>  1474
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1474
cggagaagau cgaccagcua gagaa                                             25


<210>  1475
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1475
gagaagagcc uggagcucaa guuug                                             25


<210>  1476
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1476
gacccucagc agaucuucaa gugca                                             25


<210>  1477
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1477
ccuguguggu gucucugcgu cuacu                                             25


<210>  1478
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1478
gguggucccg gagacuucac cuugu                                             25


<210>  1479
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1479
cagcgauugc uggagacaag uugua                                             25


<210>  1480
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1480
cagcuagcuu cucuuggcug cauaa                                             25


<210>  1481
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1481
cagucuccag cagugugcuc cucau                                             25


<210>  1482
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1482
aggagccaau uaaccucucu gugaa                                             25


<210>  1483
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1483
cgugagaaag gaaugguugu caaua                                             25


<210>  1484
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1484
gagaaaggaa ugguugucaa uagca                                             25


<210>  1485
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1485
caauagcaaa gagauuucug augca                                             25


<210>  1486
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1486
caguccaucc aaauuuggcc cagua                                             25


<210>  1487
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1487
cauccaaauu uggcccagua cuaua                                             25


<210>  1488
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1488
caacugggca uaugguuacu cuguu                                             25


<210>  1489
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1489
caugaagaau cuauaaugaa cauaa                                             25


<210>  1490
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1490
gagcuuucgu uacacagaau uuaga                                             25


<210>  1491
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1491
cagaauuuag aagaucagua cucaa                                             25


<210>  1492
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1492
cagacgcccu ccuucuucau gagaa                                             25


<210>  1493
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1493
caggaaaugg aaggcgcaau guuug                                             25


<210>  1494
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1494
ugguagagcu ugugcaguuu cugaa                                             25


<210>  1495
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1495
gcgcuggccg cauccuacuc cuuga                                             25


<210>  1496
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1496
aagaugaugu gauuguagcu cugaa                                             25


<210>  1497
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1497
ugccacuuug aaauuugaac cauuu                                             25


<210>  1498
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1498
ugaugacuau cuuaggacac cuuug                                             25


<210>  1499
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1499
ugacuaucuu aggacaccuu uggaa                                             25


<210>  1500
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1500
gacuaucuua ggacaccuuu ggaau                                             25


<210>  1501
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1501
acuaucuuag gacaccuuug gaaua                                             25


<210>  1502
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1502
ucuuaggaca ccuuuggaau aacua                                             25


<210>  1503
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1503
cagaucuuug ugaagacccu cacug                                             25


<210>  1504
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1504
ccagugacac cauugagaau gucaa                                             25


<210>  1505
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1505
caccugacca gcagcgucug auauu                                             25


<210>  1506
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1506
gcagcgucug auauuugccg gcaaa                                             25


<210>  1507
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1507
cagcuggagg auggccgcac ucucu                                             25


<210>  1508
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1508
gaucuucagu ugagcuuccu ccaua                                             25


<210>  1509
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1509
cggccaccug gauauuacag cuauu                                             25


<210>  1510
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1510
ccaccuggau auuacagcua uuuga                                             25


<210>  1511
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1511
cagugcagag gaugcagaau uuaug                                             25


<210>  1512
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1512
cagugacauu gugccugaca guccu                                             25


<210>  1513
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1513
gcaucccaug uucacugcua uggau                                             25


<210>  1514
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1514
gaugccugug uauauggcua auacg                                             25


<210>  1515
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1515
ggcuaauacg gaggcugcug gaucu                                             25


<210>  1516
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1516
uaauacggag gcugcuggau cuauu                                             25


<210>  1517
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1517
ggaggcugcu ggaucuauuc cuuga                                             25


<210>  1518
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1518
caacggcaag caacuugcua cugcu                                             25


<210>  1519
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1519
ccgugagacu cuggauuccu gauaa                                             25


<210>  1520
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1520
cagauuccgu uggauuugca aauuu                                             25


<210>  1521
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1521
cagcagguuc ugaucaaacu gugaa                                             25


<210>  1522
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1522
cagcuucuuc agaugguacc cuuaa                                             25


<210>  1523
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1523
caggugacag cagccaggac uugaa                                             25


<210>  1524
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1524
cagcugccac agguggucuu cucug                                             25


<210>  1525
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1525
ccgcccugcu ggacgagcug cagaa                                             25


<210>  1526
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1526
cgugagccag caggaugccc acuuu                                             25


<210>  1527
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1527
ccgugcgccu cuggccgcug uacaa                                             25


<210>  1528
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1528
ucggacaaga uuaacugcuu cgauu                                             25


<210>  1529
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1529
cggacaagau uaacugcuuc gauuu                                             25


<210>  1530
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1530
cagauacacu caugcagcaa acaca                                             25


<210>  1531
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1531
gcaaacacag uuguuuacag cucua                                             25


<210>  1532
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1532
cauucgucug auugaugcau ucaaa                                             25


<210>  1533
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1533
caccucccac auuucaucag gcaaa                                             25


<210>  1534
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1534
ggcgcccucu uacaggacau uugca                                             25


<210>  1535
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1535
caagcugaag aaggugacca acauu                                             25


<210>  1536
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1536
gcugaagaag gugaccaaca uuaau                                             25


<210>  1537
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1537
cagcccaagg gaggucucuu ccaag                                             25


<210>  1538
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1538
cacauguccu ugaaugagau gagua                                             25


<210>  1539
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1539
gagaugagua cagucuccau uucag                                             25


<210>  1540
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1540
cacagauccu ggagggcauu cauuu                                             25


<210>  1541
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1541
cagagucuca caggguuaca ccaaa                                             25


<210>  1542
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1542
gccugagaau cagccuucug gagaa                                             25


<210>  1543
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1543
gagccaaugg gagacgacga cuaug                                             25


<210>  1544
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1544
gccaugacau cgaacuccca aagaa                                             25


<210>  1545
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1545
gccagagcug agaacugccc uuaua                                             25


<210>  1546
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1546
ccagagcuga gaacugcccu uauau                                             25


<210>  1547
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1547
cacaccacug ggaacugcau caaug                                             25


<210>  1548
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1548
caaggugguu augagugcaa auacu                                             25


<210>  1549
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1549
gaggccaacu ucaagcugaa guuaa                                             25


<210>  1550
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1550
aggccaacuu caagcugaag uuaau                                             25


<210>  1551
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1551
caacuucaag cugaaguuaa uuaaa                                             25


<210>  1552
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1552
acgcaauaau caaacugucu uggaa                                             25


<210>  1553
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1553
caggaggugg uagagggcau ggaua                                             25


<210>  1554
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1554
ccuggcuuac ugaacaguaa caaua                                             25


<210>  1555
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1555
cggaaugauu ucuacugcug gguuu                                             25


<210>  1556
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1556
gaggagucca uggacuuccu ggaua                                             25


<210>  1557
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1557
caagacggga caagcaggga guuua                                             25


<210>  1558
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1558
gaaggcauuu cgaugugaau augau                                             25


<210>  1559
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1559
cggucggucc uuuacaacau caaau                                             25


<210>  1560
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1560
ccaguuugua caaacaucau guugu                                             25


<210>  1561
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1561
cgaggaggag caggaagccu ucuuu                                             25


<210>  1562
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1562
caggucaagg ugaagauguu cuuaa                                             25


<210>  1563
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1563
cagggaugug augcuggaga auuau                                             25


<210>  1564
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1564
gcagguuagg gagauggccu gguua                                             25


<210>  1565
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1565
gggacguaug gaaaguucua caaau                                             25


<210>  1566
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1566
caagaaugug cuaaggccuu uguuu                                             25


<210>  1567
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1567
gcuaaggccu uuguuuggaa gucaa                                             25


<210>  1568
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1568
gcaaggcagu uaauuggacu uuaca                                             25


<210>  1569
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1569
caggagagcc cagagguccu uugaa                                             25


<210>  1570
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1570
cagagaacug aaauuucuuc uuguu                                             25


<210>  1571
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1571
caggaauuuc ugaaugacuu aaaua                                             25


<210>  1572
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Construct

<400>  1572
gagcaguagu gugauuucau accaa                                             25


<210>  1573
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1573
gccaccgtac cagagtttcc t                                                 21


<210>  1574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1574
gccaccgtac cagagtttcc                                                   20


<210>  1575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1575
gttcactgtc ctccactcct                                                   20


<210>  1576
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1576
gttcactgtc ctccactcct g                                                 21


<210>  1577
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1577
gtcaccttag tcactccctc t                                                 21


<210>  1578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1578
acctcgtgat ccaccctcct                                                   20


<210>  1579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1579
gctctgttcc ttcctcatct                                                   20


<210>  1580
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1580
gctctgttcc ttcctcatct g                                                 21


<210>  1581
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1581
tgctctgttc cttcctcatc t                                                 21


<210>  1582
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1582
ctctgttcct tcctcatctg t                                                 21


<210>  1583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1583
gtccacattt cctctttccc                                                   20


<210>  1584
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1584
cgtccacatt tcctctttcc c                                                 21


<210>  1585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1585
cctcccatag tgtcctctcc                                                   20


<210>  1586
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1586
tccacatttc ctctttccc                                                    19


<210>  1587
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1587
cctcccatag tgtcctctcc a                                                 21


<210>  1588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1588
gggcttcctg ggtcttgctt                                                   20


<210>  1589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1589
accgctcatt gtccctctgc                                                   20


<210>  1590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1590
gcttcctggg tcttgcttgc                                                   20


<210>  1591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1591
ccgctcattg tccctctgca                                                   20


<210>  1592
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1592
accgctcatt gtccctctgc a                                                 21


<210>  1593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1593
gcccttactc ctcagacacc                                                   20


<210>  1594
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1594
gcccttactc ctcagacacc t                                                 21


<210>  1595
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1595
tctgcttgcc tctttgttcc c                                                 21


<210>  1596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1596
tctcctcttc actctttgcc                                                   20


<210>  1597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1597
ctgcttgcct ctttgttccc                                                   20


<210>  1598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1598
ttccttcatc cctcccacca                                                   20


<210>  1599
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1599
tccttcatcc ctcccacca                                                    19


<210>  1600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1600
tttccttcat ccctcccacc                                                   20


<210>  1601
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1601
tttccttcat ccctcccacc a                                                 21


<210>  1602
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1602
ttccttcatc cctcccacc                                                    19


<210>  1603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1603
gctcgccaac atgaccacca                                                   20


<210>  1604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1604
ttattgtcct ccttgtgccc                                                   20


<210>  1605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1605
ccactccagt tgtcttcaca                                                   20


<210>  1606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1606
gcccatcggt gtcctcttca                                                   20


<210>  1607
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1607
attattgtcc tccttgtgcc c                                                 21


<210>  1608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1608
gccacttgcc agctatccct                                                   20


<210>  1609
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1609
ccacttgcca gctatccct                                                    19


<210>  1610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1610
ccacttgcca gctatccctg                                                   20


<210>  1611
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1611
gtgtgccttg tacttcccgc t                                                 21


<210>  1612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1612
gtgccttgta cttcccgctc                                                   20


<210>  1613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1613
gtctccaagt gtctctgcca                                                   20


<210>  1614
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1614
cgtctccaag tgtctctgcc a                                                 21


<210>  1615
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1615
gtctccaagt gtctctgcca t                                                 21


<210>  1616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1616
ctgctccaca cactctctga                                                   20


<210>  1617
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1617
ctgctccaca cactctctg                                                    19


<210>  1618
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1618
catttcagcc agtcgtccc                                                    19


<210>  1619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1619
gcatttcagc cagtcgtccc                                                   20


<210>  1620
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1620
cccactcaca catcactcac t                                                 21


<210>  1621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1621
catttcagcc agtcgtcccg                                                   20


<210>  1622
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1622
tttcctcgtt ctccacagcc                                                   20


<210>  1623
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1623
tttcccattt ctccacct                                                     18


<210>  1624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1624
tttcctgctc ctcctactcg                                                   20


<210>  1625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1625
atttcctgct cctcctactc                                                   20


<210>  1626
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1626
ttcctgctcc tcctactcg                                                    19


<210>  1627
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1627
tttcctgctc ctcctactc                                                    19


<210>  1628
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1628
gctccctctg accacctatt c                                                 21


<210>  1629
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1629
ctccctctga ccacctattc c                                                 21


<210>  1630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1630
gctccctctg accacctatt                                                   20


<210>  1631
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1631
gctccctctg accacctat                                                    19


<210>  1632
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1632
tccctctgac cacctattcc a                                                 21


<210>  1633
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1633
gcccagccac tctcacttt                                                    19


<210>  1634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1634
gtgcccagcc actctcactt                                                   20


<210>  1635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1635
gcccagccac tctcacttta                                                   20


<210>  1636
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1636
gtgcccagcc actctcactt t                                                 21


<210>  1637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1637
tgcccagcca ctctcacttt                                                   20


<210>  1638
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1638
cccttacagt ccactttgcc t                                                 21


<210>  1639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1639
cccttacagt ccactttgcc                                                   20


<210>  1640
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1640
acccttacag tccactttgc c                                                 21


<210>  1641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1641
gtccactttg cctttgtttg                                                   20


<210>  1642
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1642
gtccactttg cctttgttt                                                    19


<210>  1643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1643
cctactctta cctccctccc                                                   20


<210>  1644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1644
ccctactctt acctccctcc                                                   20


<210>  1645
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1645
accctactct tacctccctc c                                                 21


<210>  1646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1646
accctactct tacctccctc                                                   20


<210>  1647
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1647
ctactcttac ctccctccc                                                    19


<210>  1648
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1648
gttcctcctt ccctcctttc c                                                 21


<210>  1649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1649
tcctccttcc ctcctttcca                                                   20


<210>  1650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1650
gttcctcctt ccctcctttc                                                   20


<210>  1651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1651
ttcctccttc cctcctttcc                                                   20


<210>  1652
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1652
tcctccttcc ctcctttcc                                                    19


<210>  1653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1653
gccaattaca tcccttctca                                                   20


<210>  1654
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1654
gccaattaca tcccttctca t                                                 21


<210>  1655
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1655
gccaattaca tcccttctc                                                    19


<210>  1656
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1656
cagccaatta catcccttct c                                                 21


<210>  1657
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1657
agccaattac atcccttctc a                                                 21


<210>  1658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1658
ccaagtcctc ccagccacat                                                   20


<210>  1659
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1659
caagtcctcc cagccacat                                                    19


<210>  1660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1660
caagtcctcc cagccacatg                                                   20


<210>  1661
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1661
aagtcctccc agccacatg                                                    19


<210>  1662
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1662
gtctgtgtgt ctgctcctct                                                   20


<210>  1663
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1663
tccactcctc ctccttgcga                                                   20


<210>  1664
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1664
tccactcctc ctccttgcga a                                                 21


<210>  1665
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1665
gtttcctctt ccttcttcct                                                   20


<210>  1666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1666
caccacctcc tgctcctgta                                                   20


<210>  1667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1667
ccactcctcc tccttgcgaa                                                   20


<210>  1668
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1668
ctgtcttctc ttgcctctgg a                                                 21


<210>  1669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1669
ctgtcttctc ttgcctctgg                                                   20


<210>  1670
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1670
ctgtcttctc ttgcctctg                                                    19


<210>  1671
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1671
ttcccacaga ggcacagtcc                                                   20


<210>  1672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1672
tttcccacag aggcacagtc                                                   20


<210>  1673
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1673
cctcatgctg ttcttcccac t                                                 21


<210>  1674
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1674
ccaccttcat ctccaccttc t                                                 21


<210>  1675
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1675
cttccacctt catctccacc t                                                 21


<210>  1676
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1676
tccaccttca tctccacctt c                                                 21


<210>  1677
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1677
ccacttccac cttcatctcc a                                                 21


<210>  1678
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1678
gccgtgactt gttccctctc t                                                 21


<210>  1679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1679
gccgtgactt gttccctctc                                                   20


<210>  1680
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1680
tcgccgtgac ttgttccctc t                                                 21


<210>  1681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1681
cgccgtgact tgttccctct                                                   20


<210>  1682
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1682
gccgtgactt gttccctct                                                    19


<210>  1683
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1683
cattcattcg tcctcccttc t                                                 21


<210>  1684
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1684
tcattcattc gtcctccctt c                                                 21


<210>  1685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1685
ttcattcgtc ctcccttctt                                                   20


<210>  1686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1686
tcattcgtcc tcccttcttg                                                   20


<210>  1687
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1687
ttcattcgtc ctcccttctt g                                                 21


<210>  1688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1688
gccctctcat cttctccacc                                                   20


<210>  1689
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1689
gccctctcat cttctccacc a                                                 21


<210>  1690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1690
ccctctcatc ttctccacca                                                   20


<210>  1691
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1691
ccctctcatc ttctccacc                                                    19


<210>  1692
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1692
ccctctcatc ttctccacca g                                                 21


<210>  1693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1693
tcacatgcca ctcctctcca                                                   20


<210>  1694
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1694
atcacatgcc actcctctcc a                                                 21


<210>  1695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1695
atcacatgcc actcctctcc                                                   20


<210>  1696
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1696
tcacatgcca ctcctctcc                                                    19


<210>  1697
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1697
cacatgccac tcctctcca                                                    19


<210>  1698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1698
tccaactcct ccacttgccc                                                   20


<210>  1699
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1699
atccaactcc tccacttgcc c                                                 21


<210>  1700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1700
atccaactcc tccacttgcc                                                   20


<210>  1701
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1701
tccaactcct ccacttgcc                                                    19


<210>  1702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1702
ctgccacacc ttctccaact                                                   20


<210>  1703
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1703
gcatcaccct cttcttccc                                                    19


<210>  1704
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1704
tcctttgttt gtgttgtccc t                                                 21


<210>  1705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1705
cctttgtttg tgttgtccct                                                   20


<210>  1706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1706
agcatcaccc tcttcttccc                                                   20


<210>  1707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1707
tcctttgttt gtgttgtccc                                                   20


<210>  1708
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1708
cccttctcct ctttccacgc t                                                 21


<210>  1709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1709
cccttctcct ctttccacgc                                                   20


<210>  1710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1710
gcccttctcc tctttccacg                                                   20


<210>  1711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1711
cgcccttctc ctctttccac                                                   20


<210>  1712
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1712
gcccttctcc tctttccac                                                    19


<210>  1713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1713
tcctgcctct agtctccacc                                                   20


<210>  1714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1714
ctcctgcctc tagtctccac                                                   20


<210>  1715
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1715
tcctgcctct agtctccac                                                    19


<210>  1716
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1716
ctcctgcctc tagtctcca                                                    19


<210>  1717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1717
tgcctcttcc ttcaccctgg                                                   20


<210>  1718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1718
tcccacatac tccctcctcc                                                   20


<210>  1719
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1719
tcccacatac tccctcctcc a                                                 21


<210>  1720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1720
cccacatact ccctcctcca                                                   20


<210>  1721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1721
ctcccacata ctccctcctc                                                   20


<210>  1722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1722
gctcccacat actccctcct                                                   20


<210>  1723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1723
cttcactccc ttcttcacca                                                   20


<210>  1724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1724
gcccactcct tcacccattt                                                   20


<210>  1725
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1725
tccagttctc ctcccagtct c                                                 21


<210>  1726
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1726
gcccactcct tcacccatt                                                    19


<210>  1727
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1727
cagcccactc cttcaccca                                                    19


<210>  1728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1728
gccgattcct ccatcccagt                                                   20


<210>  1729
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1729
gccgattcct ccatcccagt t                                                 21


<210>  1730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1730
gccttccttc agtcccgaga                                                   20


<210>  1731
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1731
gggctctctc actctcaatc t                                                 21


<210>  1732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1732
tctttctccc acgttgctgc                                                   20


<210>  1733
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1733
gctttctcct gctgcctctt c                                                 21


<210>  1734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1734
acccattcca gatcccgctt                                                   20


<210>  1735
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1735
acccattcca gatcccgct                                                    19


<210>  1736
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1736
ccttcttccc gtatttcct                                                    19


<210>  1737
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1737
cccattccag atcccgctt                                                    19


<210>  1738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1738
ttcccatctc agcagcctcc                                                   20


<210>  1739
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1739
ccctttccca tctcagcag                                                    19


<210>  1740
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1740
cctttcccat ctcagcagcc t                                                 21


<210>  1741
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1741
tttcccatct cagcagcctc c                                                 21


<210>  1742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1742
cctttcccat ctcagcagcc                                                   20


<210>  1743
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1743
ctcctttctc ttcgtctccc t                                                 21


<210>  1744
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1744
tctcctttct cttcgtctcc c                                                 21


<210>  1745
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1745
ctcctttctc ttcgtctccc                                                   20


<210>  1746
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1746
tcctttctct tcgtctccct                                                   20


<210>  1747
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1747
ctttctcttc gtctcccttc c                                                 21


<210>  1748
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1748
gcctttgaga cacccttccc                                                   20


<210>  1749
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1749
agcctttgag acacccttcc c                                                 21


<210>  1750
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1750
cctttgagac acccttccc                                                    19


<210>  1751
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1751
gcatctttcc catatttctc c                                                 21


<210>  1752
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1752
gtccatgccg atgaccacct                                                   20


<210>  1753
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1753
cccacttccc acacaccctt                                                   20


<210>  1754
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1754
cccacttccc acacaccctt t                                                 21


<210>  1755
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1755
ccacttccca cacacccttt                                                   20


<210>  1756
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1756
ccacttccca cacaccctt                                                    19


<210>  1757
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1757
ctgcttgcca ctcttgtcct c                                                 21


<210>  1758
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1758
cagcagtcta ccacctttcc c                                                 21


<210>  1759
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1759
agcagtctac cacctttccc                                                   20


<210>  1760
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1760
gcagtctacc acctttccc                                                    19


<210>  1761
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1761
agtacctccc tcagtgcca                                                    19


<210>  1762
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1762
tagtacctcc ctcagtgcca                                                   20


<210>  1763
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1763
tctgccacga ccatcccat                                                    19


<210>  1764
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1764
tctgccacga ccatcccata g                                                 21


<210>  1765
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1765
tctgccacga ccatcccata                                                   20


<210>  1766
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1766
ctgccacgac catcccatag                                                   20


<210>  1767
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1767
ctgccacgac catcccata                                                    19


<210>  1768
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1768
ttctcccacc tcagcctcct                                                   20


<210>  1769
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1769
attctcccac ctcagcctcc t                                                 21


<210>  1770
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1770
attctcccac ctcagcctcc                                                   20


<210>  1771
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1771
gttcttccct cccacaatgc c                                                 21


<210>  1772
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1772
ccacaccctg ccatgactct                                                   20


<210>  1773
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1773
ttctcccacc tcagcctcct                                                   20


<210>  1774
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1774
attctcccac ctcagcctcc t                                                 21


<210>  1775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1775
attctcccac ctcagcctcc                                                   20


<210>  1776
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1776
gttcttccct cccacaatgc c                                                 21


<210>  1777
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1777
ccacaccctg ccatgactct                                                   20


<210>  1778
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1778
acttccttca actcctccc                                                    19


<210>  1779
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1779
tacttccttc aactcctccc                                                   20


<210>  1780
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1780
atacttcctt caactcctcc                                                   20


<210>  1781
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1781
ctcccgcttt ctgtttcacc c                                                 21


<210>  1782
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1782
ccttctgcca tctccactac a                                                 21


<210>  1783
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1783
acttccttca actcctccc                                                    19


<210>  1784
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1784
tacttccttc aactcctccc                                                   20


<210>  1785
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1785
atacttcctt caactcctcc c                                                 21


<210>  1786
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1786
ctcccgcttt ctgtttcacc c                                                 21


<210>  1787
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1787
ccttctgcca tctccactac a                                                 21


<210>  1788
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1788
tcccacctca gcctccctta                                                   20


<210>  1789
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1789
attctcccac ctcagcctcc                                                   20


<210>  1790
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1790
tcccacctca gcctccctta t                                                 21


<210>  1791
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1791
cccacctcag cctcccttat                                                   20


<210>  1792
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1792
cccacctcag cctcccttat a                                                 21


<210>  1793
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1793
accgtcctga gttcttgccc                                                   20


<210>  1794
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1794
cagttccatc agaccagccc                                                   20


<210>  1795
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1795
gccattcacc gtcctgagtt c                                                 21


<210>  1796
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1796
gagccattca ccgtcctgag t                                                 21


<210>  1797
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1797
agttccatca gaccagccc                                                    19


<210>  1798
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1798
ccttccctct gtctctgct                                                    19


<210>  1799
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1799
ccttccctct gtctctgcta                                                   20


<210>  1800
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1800
accttccctc tgtctctgct                                                   20


<210>  1801
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1801
ccttccctct gtctctgcta t                                                 21


<210>  1802
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1802
accttccctc tgtctctgct a                                                 21


<210>  1803
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1803
gtcctctccc gcttctctct                                                   20


<210>  1804
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1804
gtcctctccc gcttctctct t                                                 21


<210>  1805
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1805
tcctctcccg cttctctctt                                                   20


<210>  1806
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1806
tcctctcccg cttctctct                                                    19


<210>  1807
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1807
tcctctcccg cttctctctt g                                                 21


<210>  1808
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1808
ctgctcttga ctgttcctcc c                                                 21


<210>  1809
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1809
gctcttgact gttcctccc                                                    19


<210>  1810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1810
tgctcttgac tgttcctccc                                                   20


<210>  1811
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1811
gtcactcctc cagcattca                                                    19


<210>  1812
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1812
gtagccttcg atgacctccc a                                                 21


<210>  1813
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1813
ccaccttctc aactctgctc c                                                 21


<210>  1814
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1814
gccaccttct caactctgct c                                                 21


<210>  1815
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1815
ccaccttctc aactctgctc                                                   20


<210>  1816
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1816
gccaccttct caactctgct                                                   20


<210>  1817
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1817
ccaccttctc aactctgct                                                    19


<210>  1818
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1818
aatcctccca cctcagcctc                                                   20


<210>  1819
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1819
caatcctccc acctcagcct                                                   20


<210>  1820
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1820
aatcctccca cctcagcct                                                    19


<210>  1821
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1821
tcccacctca gcctccctaa                                                   20


<210>  1822
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1822
agcaatcctc ccacctcagc                                                   20


<210>  1823
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1823
acctgcctct ccaccaacct                                                   20


<210>  1824
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1824
gttctctcct tattgctccc t                                                 21


<210>  1825
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1825
cctgcctctc caccaacctt                                                   20


<210>  1826
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1826
acctgcctct ccaccaacct t                                                 21


<210>  1827
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1827
cctgcctctc caccaacctt t                                                 21


<210>  1828
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1828
gacccatacc ttcttgccac a                                                 21


<210>  1829
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1829
cccatacctt cttgccacac a                                                 21


<210>  1830
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1830
gacccatacc ttcttgccac                                                   20


<210>  1831
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1831
cccatacctt cttgccacac                                                   20


<210>  1832
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1832
acccatacct tcttgccaca c                                                 21


<210>  1833
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1833
acatcccacg ccatccacct                                                   20


<210>  1834
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1834
acgccatcca cctccactca                                                   20


<210>  1835
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1835
tacatcccac gccatccacc t                                                 21


<210>  1836
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1836
cgccatccac ctccactcat                                                   20


<210>  1837
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1837
gtcctcccat acctcttcca                                                   20


<210>  1838
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1838
gccctcctcc tttctcgttc                                                   20


<210>  1839
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1839
gccctcctcc tttctcgtt                                                    19


<210>  1840
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1840
tccactcact ctgctgctgt                                                   20


<210>  1841
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1841
tccactcact ctgctgctgt t                                                 21


<210>  1842
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1842
ccctcctcct ttctcgttc                                                    19


<210>  1843
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1843
cccttcttcc actcttgctc c                                                 21


<210>  1844
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1844
ccttcttcca ctcttgctcc                                                   20


<210>  1845
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1845
cccttcttcc actcttgctc                                                   20


<210>  1846
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1846
ccttcttcca ctcttgctcc a                                                 21


<210>  1847
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1847
gcccttcttc cactcttgct c                                                 21


<210>  1848
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1848
cccttcttcc actcttgctc c                                                 21


<210>  1849
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1849
ccttcttcca ctcttgctcc                                                   20


<210>  1850
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1850
cccttcttcc actcttgctc                                                   20


<210>  1851
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1851
ccttcttcca ctcttgctcc a                                                 21


<210>  1852
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1852
gcccttcttc cactcttgct c                                                 21


<210>  1853
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1853
ctcaccacaa cctctacctc c                                                 21


<210>  1854
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1854
tcaccacaac ctctacctcc                                                   20


<210>  1855
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1855
gttcctttcc tcttcccga                                                    19


<210>  1856
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1856
ctcaccacaa cctctacctc                                                   20


<210>  1857
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1857
caccacaacc tctacctcc                                                    19


<210>  1858
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1858
tcccttccac catcccactc                                                   20


<210>  1859
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1859
tcccttccac catcccactc a                                                 21


<210>  1860
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1860
cccttccacc atcccactca                                                   20


<210>  1861
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1861
ttcccttcca ccatcccact c                                                 21


<210>  1862
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1862
tccaccatcc cactcacacc t                                                 21


<210>  1863
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1863
gccaccaagt ttcccatctc c                                                 21


<210>  1864
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1864
gccaccaagt ttcccatctc                                                   20


<210>  1865
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1865
tgccaccaag tttcccatct c                                                 21


<210>  1866
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1866
gccaccaagt ttcccatct                                                    19


<210>  1867
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1867
tgccaccaag tttcccatct                                                   20


<210>  1868
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1868
gccaccaagt ttcccatctc c                                                 21


<210>  1869
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1869
gccaccaagt ttcccatctc                                                   20


<210>  1870
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1870
tgccaccaag tttcccatct c                                                 21


<210>  1871
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1871
gccaccaagt ttcccatct                                                    19


<210>  1872
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1872
tgccaccaag tttcccatct                                                   20


<210>  1873
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1873
tctctcccta ccctcctcca                                                   20


<210>  1874
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1874
ttctctccct accctcctcc                                                   20


<210>  1875
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1875
ttctctccct accctcctcc a                                                 21


<210>  1876
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1876
cttctctccc taccctcctc                                                   20


<210>  1877
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1877
gcttctctcc ctaccctcct                                                   20


<210>  1878
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1878
cccaactccc tttccgactc t                                                 21


<210>  1879
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1879
gtcagccaca tccctttcg                                                    19


<210>  1880
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1880
cgtcagccac atccctttc                                                    19


<210>  1881
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1881
actccctttc cgactcttgc                                                   20


<210>  1882
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1882
gtcagccaca tccctttcga                                                   20


<210>  1883
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1883
actctcctct ccatcaccac t                                                 21


<210>  1884
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1884
actctcctct ccatcaccac                                                   20


<210>  1885
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1885
ctctcctctc catcaccact                                                   20


<210>  1886
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1886
gttctcacct ctccatcccg                                                   20


<210>  1887
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1887
gttctcacct ctccatccc                                                    19


<210>  1888
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1888
agccaccctc tcatccgttg                                                   20


<210>  1889
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1889
agccaccctc tcatccgtt                                                    19


<210>  1890
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1890
gagccaccct ctcatccgtt                                                   20


<210>  1891
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1891
gccactagat gtcacccttt                                                   20


<210>  1892
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1892
agccactaga tgtcaccctt                                                   20


<210>  1893
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1893
tctccctctt cccactcca                                                    19


<210>  1894
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1894
atctccctct tcccactcca                                                   20


<210>  1895
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1895
tctccctctt cccactccag                                                   20


<210>  1896
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1896
atctccctct tcccactcc                                                    19


<210>  1897
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1897
tatctccctc ttcccactcc                                                   20


<210>  1898
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1898
gctcaccact cttacttccc                                                   20


<210>  1899
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1899
ctcaccactc ttacttccc                                                    19


<210>  1900
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1900
agctcaccac tcttacttcc c                                                 21


<210>  1901
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1901
gtcccgttta tgaagagcca c                                                 21


<210>  1902
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1902
gctcaccact cttacttcc                                                    19


<210>  1903
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1903
ccaccctctc tcttccctgt                                                   20


<210>  1904
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1904
ccaccctctc tcttccctgt t                                                 21


<210>  1905
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1905
tgctgttacc tcccacctcc                                                   20


<210>  1906
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1906
ccctctctct tccctgtta                                                    19


<210>  1907
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1907
tttcatccta ccactccca                                                    19


<210>  1908
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1908
gtcttccctg aacgccacct                                                   20


<210>  1909
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1909
agtcttccct gaacgccacc t                                                 21


<210>  1910
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1910
gtcttccctg aacgccacct a                                                 21


<210>  1911
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1911
agtcttccct gaacgccacc                                                   20


<210>  1912
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1912
tcttccctga acgccaccta c                                                 21


<210>  1913
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1913
tccacctcca ctcttccctc                                                   20


<210>  1914
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1914
cacctccact cttccctcca                                                   20


<210>  1915
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1915
acctccactc ttccctcca                                                    19


<210>  1916
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1916
tccacctcca ctcttccct                                                    19


<210>  1917
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1917
atccacctcc actcttccct c                                                 21


<210>  1918
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1918
catccctcag cacctcctct                                                   20


<210>  1919
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1919
tccctcagca cctcctcttg                                                   20


<210>  1920
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1920
catccctcag cacctcctct t                                                 21


<210>  1921
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1921
tccctcagca cctcctctt                                                    19


<210>  1922
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1922
atccctcagc acctcctctt                                                   20


<210>  1923
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1923
ccctccctct tcttccttcc t                                                 21


<210>  1924
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1924
ccctccctct tcttccttcc                                                   20


<210>  1925
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1925
cctccctctt cttccttcct                                                   20


<210>  1926
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1926
cctccctctt cttccttcct g                                                 21


<210>  1927
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1927
cctccctctt cttccttcc                                                    19


<210>  1928
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1928
ccacatggag ttgctgttac a                                                 21


<210>  1929
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1929
ccacatggag ttgctgttac                                                   20


<210>  1930
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1930
ggagttgctg ttacacttga                                                   20


<210>  1931
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1931
ggagttgctg ttacacttga t                                                 21


<210>  1932
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1932
tggagttgct gttacacttg a                                                 21


<210>  1933
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1933
gtctgtcaat tcataggtc                                                    19


<210>  1934
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1934
gaagtagcac agtcatacag a                                                 21


<210>  1935
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1935
agtagcacag tcatacaga                                                    19


<210>  1936
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1936
gcctaaagaa atgacagac                                                    19


<210>  1937
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1937
atgacagaca aactcagct                                                    19


<210>  1938
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1938
taccaccacg tcccacagga                                                   20


<210>  1939
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1939
accacgtccc acaggaagca                                                   20


<210>  1940
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1940
cccacaggaa gcagacaca                                                    19


<210>  1941
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1941
accaccacgt cccacaggaa                                                   20


<210>  1942
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1942
taccaccacg tcccacagga a                                                 21


<210>  1943
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1943
gttatctcct gtaccgggtg g                                                 21


<210>  1944
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1944
gtacaaacta ctacctcagc c                                                 21


<210>  1945
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1945
gtggcctgta cagttatctc c                                                 21


<210>  1946
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1946
gcctgtacag ttatctcctg                                                   20


<210>  1947
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1947
acaaactact acctcagcct                                                   20


<210>  1948
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1948
tgtgctgcta ctttactcca                                                   20


<210>  1949
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1949
gtgctgctac tttactcca                                                    19


<210>  1950
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1950
atgtgctgct actttactcc a                                                 21


<210>  1951
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1951
atgtgctgct actttactcc                                                   20


<210>  1952
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1952
tgtgctgcta ctttactcc                                                    19


<210>  1953
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1953
accttacttc agcagcacag t                                                 21


<210>  1954
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1954
ccttacttca gcagcacagt t                                                 21


<210>  1955
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1955
ccttacttca gcagcacagt                                                   20


<210>  1956
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1956
gtcaacctta cttcagcagc a                                                 21


<210>  1957
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1957
gtcaacctta cttcagcag                                                    19


<210>  1958
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1958
tttacgtgct gctagagtgg a                                                 21


<210>  1959
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1959
ttacgtgctg ctagagtgga                                                   20


<210>  1960
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1960
tacgtgctgc tagagtgga                                                    19


<210>  1961
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1961
cgtgctgcta gagtggaac                                                    19


<210>  1962
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1962
acgtgctgct agagtggaac                                                   20


<210>  1963
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1963
cccactctct atcccttcac c                                                 21


<210>  1964
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1964
tcccactctc tatcccttca c                                                 21


<210>  1965
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1965
tcccactctc tatcccttca                                                   20


<210>  1966
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1966
ccactctcta tcccttcacc a                                                 21


<210>  1967
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1967
cctatcccac tctctatccc t                                                 21


<210>  1968
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1968
tgcctccctc tgaacaccct                                                   20


<210>  1969
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1969
ttctttgtgc ctccctctga                                                   20


<210>  1970
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1970
ctattctttg tgcctccctc t                                                 21


<210>  1971
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1971
tctttgtgcc tccctctga                                                    19


<210>  1972
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1972
attctttgtg cctccctctg                                                   20


<210>  1973
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1973
actctgatcc ctgccctgtg a                                                 21


<210>  1974
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1974
actctgatcc ctgccctgtg                                                   20


<210>  1975
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1975
actctgatcc ctgccctgt                                                    19


<210>  1976
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1976
ctctgatccc tgccctgtga                                                   20


<210>  1977
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1977
gttctctcta tcagtccctc c                                                 21


<210>  1978
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1978
atctgtacca cccgccctca                                                   20


<210>  1979
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1979
gtccctctag ctctcttccc                                                   20


<210>  1980
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1980
gcctctcttc ccagtctaca                                                   20


<210>  1981
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1981
gtccctctag ctctcttccc a                                                 21


<210>  1982
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1982
cctctcttcc cagtctacag c                                                 21


<210>  1983
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1983
gcccagtctc tctctcatgt c                                                 21


<210>  1984
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1984
gcccagtctc tctctcatgt                                                   20


<210>  1985
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1985
tccgtgtgtg acccttctcc                                                   20


<210>  1986
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1986
tgcccagtct ctctctcatg t                                                 21


<210>  1987
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1987
gtcttggagt ggcaggtggt                                                   20


<210>  1988
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1988
tcttccgctc agtctcccag t                                                 21


<210>  1989
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1989
cttccgctca gtctcccagt                                                   20


<210>  1990
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1990
ttccgctcag tctcccagtc                                                   20


<210>  1991
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1991
tgccacccac tctcgctgta                                                   20


<210>  1992
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1992
gctcagtctc ccagtcttcc                                                   20


<210>  1993
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1993
tcttccgctc agtctcccag t                                                 21


<210>  1994
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1994
cttccgctca gtctcccagt                                                   20


<210>  1995
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1995
tgccacccac tctcgctgta                                                   20


<210>  1996
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1996
ttccgctcag tctcccagtc                                                   20


<210>  1997
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1997
gctcagtctc ccagtcttcc                                                   20


<210>  1998
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1998
tccacattct cctcctcctc c                                                 21


<210>  1999
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1999
ccacattctc ctcctcctcc                                                   20


<210>  2000
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2000
ccacattctc ctcctcctcc a                                                 21


<210>  2001
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2001
cctcttccac attctcctcc t                                                 21


<210>  2002
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2002
cctcttccac attctcctcc                                                   20


<210>  2003
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2003
gttctctctt tccctgtctc                                                   20


<210>  2004
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2004
tgttctctct ttccctgtct c                                                 21


<210>  2005
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2005
acccactaca tcacctccca                                                   20


<210>  2006
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2006
cccactacat cacctccca                                                    19


<210>  2007
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2007
tgttctctct ttccctgtct                                                   20


<210>  2008
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2008
gtcccttcta tcttccattg t                                                 21


<210>  2009
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2009
tcccttctat cttccattgt c                                                 21


<210>  2010
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2010
gtcccttcta tcttccattg                                                   20


<210>  2011
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2011
gtgtcccttc tatcttccat                                                   20


<210>  2012
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2012
gtcccttcta tcttccatt                                                    19


<210>  2013
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2013
ctcgtgccct tgactcttct c                                                 21


<210>  2014
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2014
tcgtgccctt gactcttctc t                                                 21


<210>  2015
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2015
gtgcccttga ctcttctctg                                                   20


<210>  2016
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2016
cgtgcccttg actcttctct                                                   20


<210>  2017
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2017
cgtgcccttg actcttctct g                                                 21


<210>  2018
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2018
ctctctctct cttcctctcc c                                                 21


<210>  2019
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2019
tctctctctc ttcctctccc                                                   20


<210>  2020
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2020
ctctctctct tcctctccc                                                    19


<210>  2021
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2021
cccaccacct tcccacattc t                                                 21


<210>  2022
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2022
cccaccacct tcccacattc                                                   20


<210>  2023
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2023
gtagctccac cttatccctg c                                                 21


<210>  2024
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2024
gctccacctt atccctgca                                                    19


<210>  2025
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2025
agctccacct tatccctgca                                                   20


<210>  2026
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2026
tcccacaacc agagcaaccc a                                                 21


<210>  2027
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2027
tcccacaacc agagcaaccc                                                   20


<210>  2028
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2028
actccaccac ctcccatcct                                                   20


<210>  2029
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2029
actccaccac ctcccatcct t                                                 21


<210>  2030
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2030
ctccaccacc tcccatcctt                                                   20


<210>  2031
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2031
ccaccacctc ccatcctttc t                                                 21


<210>  2032
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2032
ctccaccacc tcccatcctt t                                                 21


<210>  2033
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2033
cctacttccc atatccagcc c                                                 21


<210>  2034
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2034
gcgttactcc agaccattcc c                                                 21


<210>  2035
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2035
cgccttcttc accttcccgt                                                   20


<210>  2036
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2036
gccttcttca ccttcccgt                                                    19


<210>  2037
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2037
gccttcttca ccttcccgta                                                   20


<210>  2038
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2038
acaccacacc tcacctccca                                                   20


<210>  2039
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2039
gcccagtctt ctctctccct                                                   20


<210>  2040
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2040
gcccagtctt ctctctccct t                                                 21


<210>  2041
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2041
cccagtcttc tctctccctt c                                                 21


<210>  2042
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2042
agcctccctc accttgtcct                                                   20


<210>  2043
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2043
acaccacacc tcacctccca                                                   20


<210>  2044
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2044
gcccagtctt ctctctccct                                                   20


<210>  2045
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2045
gcccagtctt ctctctccct t                                                 21


<210>  2046
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2046
cccagtcttc tctctccctt c                                                 21


<210>  2047
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2047
agcctccctc accttgtcct                                                   20


<210>  2048
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2048
gtcccaccat ttatcttctc t                                                 21


<210>  2049
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2049
gtcccaccat ttatcttctc                                                   20


<210>  2050
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2050
tcccaccatt tatcttctct g                                                 21


<210>  2051
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2051
gtcccaccat ttatcttct                                                    19


<210>  2052
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2052
tgtcccacca tttatcttct c                                                 21


<210>  2053
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2053
gtctcttcct tcttccagtg c                                                 21


<210>  2054
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2054
tccttcttcc agtgctcctc t                                                 21


<210>  2055
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2055
ccttcttcca gtgctcctct                                                   20


<210>  2056
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2056
gtctcttcct tcttccagtg                                                   20


<210>  2057
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2057
tcttccagtg ctcctcttcc                                                   20


<210>  2058
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2058
ccattgcctg ccagtttccc                                                   20


<210>  2059
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2059
cccaactcca tcccactaga                                                   20


<210>  2060
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2060
actccatccc actagaagcc                                                   20


<210>  2061
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2061
actccatccc actagaagcc g                                                 21


<210>  2062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2062
ggttctgggt ggtcttctgg                                                   20


<210>  2063
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2063
gctccttctt ctccctctcg t                                                 21


<210>  2064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2064
gtctgttcct cctcttcctc                                                   20


<210>  2065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2065
ctccttcttc tccctctcgt                                                   20


<210>  2066
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2066
gtctgtctgt tcctcctctt c                                                 21


<210>  2067
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2067
ctgtctgttc ctcctcttcc t                                                 21


<210>  2068
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2068
gccaccattg tacctgttcc c                                                 21


<210>  2069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2069
atccactcac ctcagcctcc                                                   20


<210>  2070
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2070
gtccctgctc ctgtttcca                                                    19


<210>  2071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2071
agtccctgct cctgtttcca                                                   20


<210>  2072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2072
tagtccaccc acctcagcct                                                   20


<210>  2073
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2073
gtttccagtc tctctcctcc c                                                 21


<210>  2074
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2074
gatgcccact tcccatgcca                                                   20


<210>  2075
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2075
gcttctccct cttcttctct                                                   20


<210>  2076
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2076
atgcccactt cccatgccac                                                   20


<210>  2077
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2077
tttccagtct ctctcctccc                                                   20


<210>  2078
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2078
gtacctcctt tcctcactcg c                                                 21


<210>  2079
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2079
acctcctttc ctcactcgc                                                    19


<210>  2080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2080
tacctccttt cctcactcgc                                                   20


<210>  2081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2081
gtacctcctt tcctcactcg                                                   20


<210>  2082
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2082
gtacctcctt tcctcactc                                                    19


<210>  2083
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2083
gtacctcctt tcctcactcg c                                                 21


<210>  2084
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2084
acctcctttc ctcactcgc                                                    19


<210>  2085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2085
tacctccttt cctcactcgc                                                   20


<210>  2086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2086
gtacctcctt tcctcactcg                                                   20


<210>  2087
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2087
gtacctcctt tcctcactc                                                    19


<210>  2088
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2088
cttcacacca gagccaccat c                                                 21


<210>  2089
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2089
tcacaccaga gccaccatca g                                                 21


<210>  2090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2090
acttcacacc agagccacca                                                   20


<210>  2091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2091
tcacaccaga gccaccatca                                                   20


<210>  2092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2092
cacaccagag ccaccatcag                                                   20


<210>  2093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2093
gtctcgccat tctccaccac                                                   20


<210>  2094
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2094
gtctcgccat tctccaccac a                                                 21


<210>  2095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2095
gccattctcc accacatcct                                                   20


<210>  2096
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2096
gtctcgccat tctccacca                                                    19


<210>  2097
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2097
gccattctcc accacatcct t                                                 21


<210>  2098
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2098
gccactgctt gctcactctt c                                                 21


<210>  2099
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2099
cctcccgtat tgtcacttcc t                                                 21


<210>  2100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2100
agtccgcctc ttccagtcac                                                   20


<210>  2101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2101
cctcccgtat tgtcacttcc                                                   20


<210>  2102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2102
gccactgctt gctcactctt                                                   20


<210>  2103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2103
ttcctgttcc ctgtgtgccc                                                   20


<210>  2104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2104
tttcctgttc cctgtgtgcc c                                                 21


<210>  2105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2105
tttcctgttc cctgtgtgcc                                                   20


<210>  2106
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2106
ttcctgttcc ctgtgtgcc                                                    19


<210>  2107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2107
cccatttcct gttccctgtg t                                                 21


<210>  2108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2108
tcctccactt cctcctcttc c                                                 21


<210>  2109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2109
cctccacttc ctcctcttcc                                                   20


<210>  2110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2110
cctccacttc ctcctcttcc a                                                 21


<210>  2111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2111
ccacttcctc ctcttccacc t                                                 21


<210>  2112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2112
tccacttcct cctcttccac c                                                 21


<210>  2113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2113
gctccctacc gagatgccat                                                   20


<210>  2114
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2114
gttcaccatc tcctgcctg                                                    19


<210>  2115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2115
gtttggtctc tagcctctcc                                                   20


<210>  2116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2116
gcagtttggt ctctagcctc t                                                 21


<210>  2117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2117
agtttggtct ctagcctctc c                                                 21


<210>  2118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2118
gctcttaccc tatgtcttcc c                                                 21


<210>  2119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2119
acagccacca ttcttccaca                                                   20


<210>  2120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2120
gctctcatac catacatccc a                                                 21


<210>  2121
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2121
gctgtcttcc tccactttg                                                    19


<210>  2122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2122
tgctgtcttc ctccactttg                                                   20


<210>  2123
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2123
gctcttaccc tatgtcttcc c                                                 21


<210>  2124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2124
acagccacca ttcttccaca                                                   20


<210>  2125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2125
gctctcatac catacatccc a                                                 21


<210>  2126
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2126
gctgtcttcc tccactttg                                                    19


<210>  2127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2127
tgctgtcttc ctccactttg                                                   20


<210>  2128
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2128
acctcttccc gcccgattt                                                    19


<210>  2129
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2129
acctcttccc gcccgattt                                                    19


<210>  2130
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2130
tttacctctt cccgcccga                                                    19


<210>  2131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2131
tacctcttcc cgcccgattt                                                   20


<210>  2132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2132
ttacctcttc ccgcccgatt                                                   20


<210>  2133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2133
aggagcagag cagagttggg                                                   20


<210>  2134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2134
tcaggagcag agcagagttg g                                                 21


<210>  2135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2135
cttcaggagc agagcagagt t                                                 21


<210>  2136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2136
cttcaggagc agagcagagt                                                   20


<210>  2137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2137
caggagcaga gcagagttgg                                                   20


<210>  2138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2138
gcgatctcct ccaccttcat                                                   20


<210>  2139
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2139
gcgatctcct ccaccttca                                                    19


<210>  2140
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2140
gcgatctcct ccaccttcat g                                                 21


<210>  2141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2141
ggtggtcagg tcccggtatt                                                   20


<210>  2142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2142
gacccactac cttgtactct c                                                 21


<210>  2143
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2143
ctctccacca tagcacttcc c                                                 21


<210>  2144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2144
cctcccattg tagccgtcct                                                   20


<210>  2145
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2145
ctccaccata gcacttcccg t                                                 21


<210>  2146
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2146
cctcccattg tagccgtcct t                                                 21


<210>  2147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2147
tctccaccat agcacttccc                                                   20


<210>  2148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2148
gcacctgtcc ttctgtcctc                                                   20


<210>  2149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2149
gcacctgtcc ttctgtcctc a                                                 21


<210>  2150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2150
ggcacctgtc cttctgtcct                                                   20


<210>  2151
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2151
gcacctgtcc ttctgtcct                                                    19


<210>  2152
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2152
tggcacctgt ccttctgtcc t                                                 21


<210>  2153
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2153
ggttgtttgt gctgtggttc t                                                 21


<210>  2154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2154
ggttgtttgt gctgtggttc                                                   20


<210>  2155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2155
ctggttgttt gtgctgtggt                                                   20


<210>  2156
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2156
ctggttgttt gtgctgtggt t                                                 21


<210>  2157
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2157
tggttgtttg tgctgtggtt c                                                 21


<210>  2158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2158
gcctccacca cctccttctt                                                   20


<210>  2159
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2159
cctccaccac ctccttctt                                                    19


<210>  2160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2160
agcctccacc acctccttct                                                   20


<210>  2161
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2161
agcctccacc acctccttct t                                                 21


<210>  2162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2162
gttcccacca cacagccttt c                                                 21


<210>  2163
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2163
gtgctttccc aaccttctt                                                    19


<210>  2164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2164
gtgctttccc aaccttcttg                                                   20


<210>  2165
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2165
gctttctgac tctgtgcttg t                                                 21


<210>  2166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2166
gggttcggga cagcctagtt                                                   20


<210>  2167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2167
ggaccattct gagtgcctgc                                                   20


<210>  2168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2168
gctcgtctct tcatcttggt                                                   20


<210>  2169
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2169
gctcgtctct tcatcttggt t                                                 21


<210>  2170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2170
gaaccacagt gccagatccc                                                   20


<210>  2171
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2171
aaccacagtg ccagatccc                                                    19


<210>  2172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2172
ctcgtctctt catcttggtt                                                   20


<210>  2173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2173
gtcccaccac ctcgaactct                                                   20


<210>  2174
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2174
agtcccacca cctcgaactc t                                                 21


<210>  2175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2175
tcccaccacc tcgaactctg                                                   20


<210>  2176
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2176
tcccaccacc tcgaactct                                                    19


<210>  2177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2177
agtcccacca cctcgaactc                                                   20


<210>  2178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2178
gtcccagtct tgcctttccc t                                                 21


<210>  2179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2179
gtcccagtct tgcctttccc                                                   20


<210>  2180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2180
gagccacctt ctttcccttg                                                   20


<210>  2181
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2181
gagccacctt ctttccctt                                                    19


<210>  2182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2182
tcccagtctt gcctttccct                                                   20


<210>  2183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2183
agttctcccg ccctcttggt                                                   20


<210>  2184
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2184
cgttccacct catcctcag                                                    19


<210>  2185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2185
cgttccacct catcctcagt                                                   20


<210>  2186
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2186
gttccacctc atcctcagt                                                    19


<210>  2187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2187
tcagtgagtt ctcccgccct                                                   20


<210>  2188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2188
acttcccgag ccagcatcca                                                   20


<210>  2189
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2189
gagccagcat ccaccacatc a                                                 21


<210>  2190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2190
gagccagcat ccaccacatc                                                   20


<210>  2191
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2191
aacttcccga gccagcatcc a                                                 21


<210>  2192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2192
aacttcccga gccagcatcc                                                   20


<210>  2193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2193
cacctcacca tctctcaccc                                                   20


<210>  2194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2194
cacctcacca tctctcaccc a                                                 21


<210>  2195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2195
acctcaccat ctctcaccca                                                   20


<210>  2196
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2196
tcaccttcac cttcctcacc a                                                 21


<210>  2197
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2197
tcaccttcac cttcctcacc                                                   20


<210>  2198
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2198
gtcctctgat ctcctccctc t                                                 21


<210>  2199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2199
gtcctctgat ctcctccctc                                                   20


<210>  2200
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2200
cctctgatct cctccctctg t                                                 21


<210>  2201
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2201
cgccactccc acagacatac a                                                 21


<210>  2202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2202
gccactccca cagacataca                                                   20


<210>  2203
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2203
ccttccttct gtgcctgcca                                                   20


<210>  2204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2204
agcccttcct tctgtgcctg                                                   20


<210>  2205
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2205
agcccttcct tctgtgcct                                                    19


<210>  2206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2206
cagcccttcc ttctgtgcct                                                   20


<210>  2207
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2207
atctctccag tgtgtgcca                                                    19


<210>  2208
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2208
gcctctccct cctctagttg                                                   20


<210>  2209
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2209
gcctctccct cctctagtt                                                    19


<210>  2210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2210
cgcctctccc tcctctagtt                                                   20


<210>  2211
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2211
gttcctgctt tcgtctctcc c                                                 21


<210>  2212
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2212
ttcctgcttt cgtctctccc                                                   20


<210>  2213
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2213
ggtgggaatg ggtgaggatg t                                                 21


<210>  2214
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2214
gttcacccgt attggcttcc c                                                 21


<210>  2215
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2215
gccagtgact ctatcctttg g                                                 21


<210>  2216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2216
caggattggg agcagagggt                                                   20


<210>  2217
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2217
tgggtgagga tgtgagtgt                                                    19


<210>  2218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2218
agtcttcccg ctttcctccg                                                   20


<210>  2219
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2219
agtcttcccg ctttcctcc                                                    19


<210>  2220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2220
agccaccaca tccagccagt                                                   20


<210>  2221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2221
accaactctc tcactcaccc                                                   20


<210>  2222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2222
gagtcttccc gctttcctcc                                                   20


<210>  2223
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2223
cctccctgct ttacaatccc t                                                 21


<210>  2224
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2224
tcctccctgc tttacaatcc c                                                 21


<210>  2225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2225
cctccctgct ttacaatccc                                                   20


<210>  2226
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2226
gttcccattc tcatccgtg                                                    19


<210>  2227
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2227
gtttcctccc tgctttaca                                                    19


<210>  2228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2228
ctgccatcat ctcccatccc                                                   20


<210>  2229
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2229
gtcttgcttc ccgttcctgt c                                                 21


<210>  2230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2230
gccatcatct cccatcccat                                                   20


<210>  2231
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2231
gccatcatct cccatccca                                                    19


<210>  2232
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2232
gccatcatct cccatcccat t                                                 21


<210>  2233
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2233
ttcctccctc tctctccac                                                    19


<210>  2234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2234
gttcctccct ctctctccac                                                   20


<210>  2235
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2235
cctcctccca ccttacctca                                                   20


<210>  2236
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2236
gttcctccct ctctctcca                                                    19


<210>  2237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2237
ccttctcctc ctcctcccat                                                   20


<210>  2238
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2238
gttgccacag tatcttctcc c                                                 21


<210>  2239
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2239
ctgtcttccc actgcctttc t                                                 21


<210>  2240
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2240
gccacagtat cttctcccat                                                   20


<210>  2241
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2241
tctgtcttcc cactgccttt c                                                 21


<210>  2242
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2242
gccacagtat cttctccca                                                    19


<210>  2243
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2243
tcctgtctcc tgtctcttct                                                   20


<210>  2244
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2244
cttcctgtct cctgtctctt c                                                 21


<210>  2245
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2245
ttcctgtctc ctgtctcttc t                                                 21


<210>  2246
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2246
gcttcctgtc tcctgtctct                                                   20


<210>  2247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2247
cttcctgtct cctgtctctt                                                   20


<210>  2248
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2248
gtccctctag cctgtgtcct                                                   20


<210>  2249
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2249
agtccctcta gcctgtgtcc t                                                 21


<210>  2250
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2250
tccctctagc ctgtgtcctc t                                                 21


<210>  2251
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2251
agtccctcta gcctgtgtcc                                                   20


<210>  2252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2252
tccctctagc ctgtgtcctc                                                   20


<210>  2253
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2253
gatcaacagt gcccattctc t                                                 21


<210>  2254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2254
atcaacagtg cccattctct                                                   20


<210>  2255
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2255
tcaacagtgc ccattctcta g                                                 21


<210>  2256
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2256
tcaacagtgc ccattctct                                                    19


<210>  2257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2257
tcaacagtgc ccattctcta                                                   20


<210>  2258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2258
gtcttgtaat tccttcccac                                                   20


<210>  2259
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2259
ctgtcttgta attccttccc                                                   20


<210>  2260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2260
gtaattcctt cccacagatc                                                   20


<210>  2261
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2261
gtcttgtaat tccttcccac a                                                 21


<210>  2262
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2262
gtcttgtaat tccttccca                                                    19


<210>  2263
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2263
ctgaaggaga ctggcagcat t                                                 21


<210>  2264
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2264
ctgaaggaga ctggcagcat                                                   20


<210>  2265
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2265
ctgaaggaga ctggcagca                                                    19


<210>  2266
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2266
gaaggagact ggcagcatta c                                                 21


<210>  2267
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2267
aggagactgg cagcattac                                                    19


<210>  2268
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2268
ggactctagc acactcaggc a                                                 21


<210>  2269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2269
ggactctagc acactcaggc                                                   20


<210>  2270
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2270
aggactctag cacactcagg c                                                 21


<210>  2271
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2271
ggactctagc acactcagg                                                    19


<210>  2272
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2272
gactctagca cactcaggca                                                   20


<210>  2273
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2273
gtcatgtcca cagcaaatg                                                    19


<210>  2274
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2274
gtcatgtcca cagcaaatga g                                                 21


<210>  2275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2275
gtcatgtcca cagcaaatga                                                   20


<210>  2276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2276
catgtccaca gcaaatgaga                                                   20


<210>  2277
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2277
tcatgtccac agcaaatgag a                                                 21


<210>  2278
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2278
gggaaccaca gacacgcctt                                                   20


<210>  2279
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2279
gggaaccaca gacacgcctt t                                                 21


<210>  2280
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2280
gctggcctca aagtttccca                                                   20


<210>  2281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2281
agctggcctc aaagtttccc                                                   20


<210>  2282
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2282
agctggcctc aaagtttccc a                                                 21


<210>  2283
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2283
tctgtaagtc tttgtccacg t                                                 21


<210>  2284
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2284
cctatctgta agtctttgtc c                                                 21


<210>  2285
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2285
ctgtaagtct ttgtccacgt t                                                 21


<210>  2286
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2286
ctgtaagtct ttgtccacgt                                                   20


<210>  2287
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2287
tctgtaagtc tttgtccacg                                                   20


<210>  2288
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2288
gtactctagc acaccaggac a                                                 21


<210>  2289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2289
gtactctagc acaccaggac                                                   20


<210>  2290
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2290
gtatgtttct gatctgggca c                                                 21


<210>  2291
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2291
gtatgtttct gatctgggca                                                   20


<210>  2292
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2292
atgtttctga tctgggcact                                                   20


<210>  2293
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2293
agccaccagt cagtcagtca                                                   20


<210>  2294
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2294
gccaccagtc agtcagtca                                                    19


<210>  2295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2295
gccaccagtc agtcagtcat                                                   20


<210>  2296
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2296
gccaccagtc agtcagtcat g                                                 21


<210>  2297
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2297
agccaccagt cagtcagtca t                                                 21


<210>  2298
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2298
gcacacttcc gacactcag                                                    19


<210>  2299
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2299
agcacacttc cgacactcag                                                   20


<210>  2300
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2300
gcctccaccc tgagcttta                                                    19


<210>  2301
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2301
tagcacactt ccgacactca g                                                 21


<210>  2302
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2302
agcacacttc cgacactca                                                    19


<210>  2303
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2303
gccagtcagt agcctcaact c                                                 21


<210>  2304
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2304
gccagtcagt agcctcaact                                                   20


<210>  2305
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2305
gccagtcagt agcctcaac                                                    19


<210>  2306
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2306
ccagtcagta gcctcaactc c                                                 21


<210>  2307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2307
agtcagtagc ctcaactcca                                                   20


<210>  2308
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2308
tctagcgctg cagattgacc c                                                 21


<210>  2309
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2309
ctagcgctgc agattgaccc                                                   20


<210>  2310
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2310
gcacatgctc tagcgctgca                                                   20


<210>  2311
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2311
tagcgctgca gattgaccc                                                    19


<210>  2312
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2312
tctagcgctg cagattgacc                                                   20


<210>  2313
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2313
ctgacctttg aacaccctag c                                                 21


<210>  2314
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2314
gcactgacct ttgaacaccc t                                                 21


<210>  2315
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2315
gacctttgaa caccctagca g                                                 21


<210>  2316
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2316
gacctttgaa caccctagca                                                   20


<210>  2317
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2317
tgacctttga acaccctagc a                                                 21


<210>  2318
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2318
agcatccagc aaccacaggg                                                   20


<210>  2319
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2319
acagcatcca gcaaccacag g                                                 21


<210>  2320
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2320
cagcatccag caaccacagg                                                   20


<210>  2321
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2321
agcatccagc aaccacagg                                                    19


<210>  2322
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2322
acagcatcca gcaaccacag                                                   20


<210>  2323
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2323
tttcgtcaac cttctgtacc a                                                 21


<210>  2324
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2324
ttcgtcaacc ttctgtacca                                                   20


<210>  2325
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2325
tcgtcaacct tctgtacca                                                    19


<210>  2326
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2326
tttcgtcaac cttctgtacc                                                   20


<210>  2327
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2327
ttcgtcaacc ttctgtacc                                                    19


<210>  2328
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2328
acacggacca atgaagtgg                                                    19


<210>  2329
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2329
aacacggacc aatgaagtgg                                                   20


<210>  2330
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2330
aaacacggac caatgaagtg g                                                 21


<210>  2331
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2331
gttcagaaac acggaccaat g                                                 21


<210>  2332
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2332
agaaacacgg accaatgaag t                                                 21


<210>  2333
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2333
gtttcagaaa cacggacca                                                    19


<210>  2334
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2334
gtttcagaaa cacggaccaa t                                                 21


<210>  2335
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2335
gtttcagaaa cacggaccaa                                                   20


<210>  2336
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2336
tttcagaaac acggaccaa                                                    19


<210>  2337
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2337
tcagaaacac ggaccaatt                                                    19


<210>  2338
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2338
gaccttaagt ggaatctcat c                                                 21


<210>  2339
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2339
cggaccttaa gtggaatctc a                                                 21


<210>  2340
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2340
acggacctta agtggaatct c                                                 21


<210>  2341
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2341
ggaccttaag tggaatctca t                                                 21


<210>  2342
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2342
ggaccttaag tggaatctca                                                   20


<210>  2343
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2343
tgtcatcacc atctctcag                                                    19


<210>  2344
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2344
tcagcgatct tggtggttt                                                    19


<210>  2345
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2345
tcagcgatct tggtggttta                                                   20


<210>  2346
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2346
gcatcagcga tcttggtggt t                                                 21


<210>  2347
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2347
gcatcagcga tcttggtggt                                                   20


<210>  2348
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2348
ctttctcagc agtgcccacg t                                                 21


<210>  2349
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2349
tttctcagca gtgcccacgt                                                   20


<210>  2350
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2350
ttctcagcag tgcccacgt                                                    19


<210>  2351
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2351
ctttctcagc agtgcccacg                                                   20


<210>  2352
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2352
ctttctcagc agtgcccac                                                    19


<210>  2353
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2353
catggattcg cacttcaagg t                                                 21


<210>  2354
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2354
ggattcgcac ttcaaggttg                                                   20


<210>  2355
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2355
tggattcgca cttcaaggtt g                                                 21


<210>  2356
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2356
ctcatggatt cgcacttca                                                    19


<210>  2357
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2357
atggattcgc acttcaaggt t                                                 21


<210>  2358
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2358
cttcacagta atttcaggc                                                    19


<210>  2359
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2359
cttcacagta atttcaggcc a                                                 21


<210>  2360
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2360
cttcacagta atttcaggcc                                                   20


<210>  2361
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2361
tcacagtaat ttcaggcca                                                    19


<210>  2362
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2362
tcacagtaat ttcaggccaa g                                                 21


<210>  2363
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2363
gcctcagatg caatgctgac c                                                 21


<210>  2364
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2364
cagatgcaat gctgaccaca                                                   20


<210>  2365
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2365
cagatgcaat gctgaccac                                                    19


<210>  2366
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2366
cagatgcaat gctgaccaca t                                                 21


<210>  2367
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2367
ccacatggtt tattcaggt                                                    19


<210>  2368
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2368
ttctctccct ctcactccc                                                    19


<210>  2369
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2369
gttctctccc tctcactccc                                                   20


<210>  2370
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2370
cgttctctcc ctctcactcc                                                   20


<210>  2371
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2371
gttctctccc tctcactcc                                                    19


<210>  2372
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2372
gcgttctctc cctctcactc                                                   20


<210>  2373
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2373
agtttctgtc cgcccgtca                                                    19


<210>  2374
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2374
gtttctgtcc gcccgtcaat                                                   20


<210>  2375
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2375
gtttctgtcc gcccgtcaa                                                    19


<210>  2376
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2376
agtttctgtc cgcccgtcaa                                                   20


<210>  2377
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2377
agtttctgtc cgcccgtcaa t                                                 21


<210>  2378
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2378
accttcatgt tcagtcagca                                                   20


<210>  2379
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2379
accttcatgt tcagtcagca t                                                 21


<210>  2380
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2380
ccttcatgtt cagtcagcat                                                   20


<210>  2381
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2381
ccttcatgtt cagtcagcat t                                                 21


<210>  2382
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2382
ccttcatgtt cagtcagca                                                    19


<210>  2383
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2383
cccgttatca ttcagcagtt g                                                 21


<210>  2384
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2384
cccgttatca ttcagcagtt                                                   20


<210>  2385
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2385
cccgttatca ttcagcagt                                                    19


<210>  2386
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2386
gcccgttatc attcagcagt                                                   20


<210>  2387
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2387
gcccgttatc attcagcagt t                                                 21


<210>  2388
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2388
cccgttatca ttcagcagtt g                                                 21


<210>  2389
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2389
cccgttatca ttcagcagtt                                                   20


<210>  2390
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2390
cccgttatca ttcagcagt                                                    19


<210>  2391
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2391
gcccgttatc attcagcagt                                                   20


<210>  2392
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2392
gcccgttatc attcagcagt t                                                 21


<210>  2393
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2393
acatttcgcc catcatcat                                                    19


<210>  2394
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2394
catttcgccc atcatcata                                                    19


<210>  2395
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2395
aacatttcgc ccatcatca                                                    19


<210>  2396
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2396
ttcgcccatc atcataacat c                                                 21


<210>  2397
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2397
gagcagttga acatttcgcc c                                                 21


<210>  2398
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2398
gaggtgtcag aagtcaaagc a                                                 21


<210>  2399
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2399
catacgaggt gtcagaagtc a                                                 21


<210>  2400
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2400
cgaggtgtca gaagtcaaag c                                                 21


<210>  2401
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2401
gaggtgtcag aagtcaaagc                                                   20


<210>  2402
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2402
catacgaggt gtcagaagtc                                                   20


<210>  2403
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2403
tcatgtcaga cgatcaatg                                                    19


<210>  2404
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2404
tcatgtcaga cgatcaatgc a                                                 21


<210>  2405
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2405
atcatgtcag acgatcaatg c                                                 21


<210>  2406
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2406
catgtcagac gatcaatgca                                                   20


<210>  2407
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2407
gtcagacgat caatgcaatc a                                                 21


<210>  2408
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2408
gtcagatgtc cctaccaac                                                    19


<210>  2409
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2409
actgtcagat gtccctacc                                                    19


<210>  2410
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2410
ttactgtcag atgtccctac c                                                 21


<210>  2411
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2411
tactgtcaga tgtccctacc                                                   20


<210>  2412
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2412
acacaggctt catcagagg                                                    19


<210>  2413
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2413
tcccttctgt ccactactct                                                   20


<210>  2414
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2414
tcccttctgt ccactactct t                                                 21


<210>  2415
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2415
atcccttctg tccactactc t                                                 21


<210>  2416
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2416
atcccttctg tccactactc                                                   20


<210>  2417
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2417
tcccttctgt ccactactc                                                    19


<210>  2418
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2418
tcctcatcat tctagcactc a                                                 21


<210>  2419
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2419
tcctcatcat tctagcactc                                                   20


<210>  2420
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2420
atcctcatca ttctagcact c                                                 21


<210>  2421
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2421
cctcatcatt ctagcactca                                                   20


<210>  2422
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2422
cctcatcatt ctagcactc                                                    19


<210>  2423
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2423
gcaaccatca tagtatctg                                                    19


<210>  2424
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2424
tctgctgaac tatgcaacca t                                                 21


<210>  2425
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2425
atctgctgaa ctatgcaacc a                                                 21


<210>  2426
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2426
tctgctgaac tatgcaacca                                                   20


<210>  2427
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2427
atctgctgaa ctatgcaacc                                                   20


<210>  2428
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2428
ggtcagacat ttgatcaac                                                    19


<210>  2429
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2429
caggtcagac atttgatcaa c                                                 21


<210>  2430
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2430
caggtcagac atttgatca                                                    19


<210>  2431
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2431
tcaggtcaga catttgatc                                                    19


<210>  2432
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2432
gctcatttca ggtcagacat t                                                 21


<210>  2433
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2433
ctcatcagcg ttagtctgc                                                    19


<210>  2434
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2434
gctcatcagc gttagtctgc                                                   20


<210>  2435
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2435
gctcatcagc gttagtctgc t                                                 21


<210>  2436
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2436
catcagatag gagcgaaaga c                                                 21


<210>  2437
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2437
gcgttagtct gctgaactat g                                                 21


<210>  2438
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2438
gagagagttc aagttggatt g                                                 21


<210>  2439
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2439
cagtgagaga gttcaagttg g                                                 21


<210>  2440
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2440
agtgagagag ttcaagttgg a                                                 21


<210>  2441
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2441
gtgagagagt tcaagttgga t                                                 21


<210>  2442
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2442
gagagagttc aagttggat                                                    19


<210>  2443
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2443
ggaaggcagt agagaatggt t                                                 21


<210>  2444
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2444
aggaaggcag tagagaatgg t                                                 21


<210>  2445
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2445
ggaaggcagt agagaatggt                                                   20


<210>  2446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2446
ctcagaagga aggcagtaga                                                   20


<210>  2447
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2447
tcagaaggaa ggcagtagag a                                                 21


<210>  2448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2448
acggttccgc agtctgtctc                                                   20


<210>  2449
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2449
ctcagaagga aggcaacaag g                                                 21


<210>  2450
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2450
aggaaggcaa caaggaacgg                                                   20


<210>  2451
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2451
aggaaggcaa caaggaacgg t                                                 21


<210>  2452
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2452
tcagaaggaa ggcaacaagg a                                                 21


<210>  2453
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2453
catcttctcc cttacaccct                                                   20


<210>  2454
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2454
acatcttctc ccttacaccc t                                                 21


<210>  2455
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2455
acatcttctc ccttacaccc                                                   20


<210>  2456
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2456
cttcttggct ccctccttcc                                                   20


<210>  2457
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2457
atcttctccc ttacaccct                                                    19


<210>  2458
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2458
gtcgtcaact cccaccagct                                                   20


<210>  2459
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2459
cccacaaccc aacttcccga                                                   20


<210>  2460
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2460
gtcctgccat accacccatg                                                   20


<210>  2461
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2461
agtcctgcca taccacccat                                                   20


<210>  2462
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2462
agtcctgcca taccaccca                                                    19


<210>  2463
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2463
gtcgtcaact cccaccagct                                                   20


<210>  2464
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2464
cccacaaccc aacttcccga                                                   20


<210>  2465
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2465
gtcctgccat accacccatg                                                   20


<210>  2466
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2466
agtcctgcca taccacccat                                                   20


<210>  2467
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2467
agtcctgcca taccaccca                                                    19


<210>  2468
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2468
ccttcctctt cctcctccct                                                   20


<210>  2469
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2469
accttcctct tcctcctccc t                                                 21


<210>  2470
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2470
accttcctct tcctcctccc                                                   20


<210>  2471
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2471
cttcctcttc ctcctccctg                                                   20


<210>  2472
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2472
cttcctcttc ctcctccct                                                    19


<210>  2473
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2473
gctcctgttc ctcccgttca                                                   20


<210>  2474
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2474
gtctccttct tcatcactcc c                                                 21


<210>  2475
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2475
tctccttctt catcactccc a                                                 21


<210>  2476
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2476
tctccttctt catcactccc                                                   20


<210>  2477
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2477
ctcctcctcc tgttcttctg t                                                 21


<210>  2478
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2478
tcagccctcc aactcccgat                                                   20


<210>  2479
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2479
tcagccctcc aactcccgat a                                                 21


<210>  2480
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2480
cagccctcca actcccgata                                                   20


<210>  2481
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2481
cctctgctgt tgactcctc                                                    19


<210>  2482
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2482
agccctccaa ctcccgata                                                    19


<210>  2483
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2483
cctctttctc tctctctccc t                                                 21


<210>  2484
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2484
tcctctttct ctctctctcc c                                                 21


<210>  2485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2485
cctctttctc tctctctccc                                                   20


<210>  2486
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2486
gtgtccctct gccatcctca                                                   20


<210>  2487
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2487
ctctttctct ctctctccct c                                                 21


<210>  2488
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2488
actcctcctc ctcttcctcc t                                                 21


<210>  2489
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2489
actcctcctc ctcttcctcc                                                   20


<210>  2490
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2490
ctcctcttcc tcctcctcct                                                   20


<210>  2491
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2491
ctcctcctct tcctcctcct                                                   20


<210>  2492
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2492
ctcctcctcc tcttcctcct                                                   20


<210>  2493
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2493
ccctctcctc tggtcttgct                                                   20


<210>  2494
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2494
acccttcacc agcctcttca                                                   20


<210>  2495
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2495
tggtgtctgg cttctggtgg                                                   20


<210>  2496
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2496
cccttcacca gcctcttca                                                    19


<210>  2497
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2497
cccttcacca gcctcttcat                                                   20


<210>  2498
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2498
tcccgctccc tcctcttctt                                                   20


<210>  2499
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2499
ttcccgctcc ctcctcttct                                                   20


<210>  2500
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2500
tcttcccgct ccctcctctt                                                   20


<210>  2501
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2501
ttcttcccgc tccctcctct                                                   20


<210>  2502
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2502
tcccgctccc tcctcttctt t                                                 21


<210>  2503
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2503
ttattcctcc ctccctgcc                                                    19


<210>  2504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2504
tgttcctctt tcttgtccct                                                   20


<210>  2505
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2505
gttcctcttt cttgtccct                                                    19


<210>  2506
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2506
tattcctccc tccctgccca                                                   20


<210>  2507
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2507
tttattcctc cctccctgcc c                                                 21


<210>  2508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2508
tttcctctct cctcctgccc                                                   20


<210>  2509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2509
gtcattctcg ccctcccttt                                                   20


<210>  2510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2510
ctcctccgtg cttctctcct                                                   20


<210>  2511
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2511
gtcattctcg ccctccctt                                                    19


<210>  2512
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2512
tttcctctct cctcctgcc                                                    19


<210>  2513
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2513
gttctcagcc attctcccac c                                                 21


<210>  2514
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2514
cttcctccct acccaactcc t                                                 21


<210>  2515
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2515
tctcagccat tctcccacca c                                                 21


<210>  2516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2516
tctcagccat tctcccacca                                                   20


<210>  2517
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2517
tcttcctccc tacccaactc c                                                 21


<210>  2518
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2518
agggaggtgg gttgttggt                                                    19


<210>  2519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2519
cagggaggtg ggttgttggt                                                   20


<210>  2520
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2520
actctccttg tcttgctggg t                                                 21


<210>  2521
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2521
ggttctggtg ggcatgtctt c                                                 21


<210>  2522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2522
agggaggtgg gttgttggtc                                                   20


<210>  2523
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2523
cacatttctc cacttccttc c                                                 21


<210>  2524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2524
actccattct cctcctcact                                                   20


<210>  2525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2525
acatttctcc acttccttcc                                                   20


<210>  2526
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2526
catttctcca cttccttcc                                                    19


<210>  2527
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2527
actccattct cctcctcac                                                    19


<210>  2528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2528
ctctttccca ccgttatgcc                                                   20


<210>  2529
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2529
tttcctctct ttcccaccg                                                    19


<210>  2530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2530
ttcctctctt tcccaccgtt                                                   20


<210>  2531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2531
tttcctctct ttcccaccgt                                                   20


<210>  2532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2532
tcccaccgtt atgccagagt                                                   20


<210>  2533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2533
ggtgtcctaa gatagtcatc                                                   20


<210>  2534
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2534
gtgtcctaag atagtcatc                                                    19


<210>  2535
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2535
ggtgtcctaa gatagtcat                                                    19


<210>  2536
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2536
ggtgtcctaa gatagtcatc a                                                 21


<210>  2537
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2537
gtgtcctaag atagtcatca c                                                 21


<210>  2538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2538
cactcttcag ccacctccct                                                   20


<210>  2539
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2539
actcttcagc cacctccct                                                    19


<210>  2540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2540
actcttcagc cacctccctg                                                   20


<210>  2541
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2541
atccctgtta ctccctccc                                                    19


<210>  2542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2542
tatccctgtt actccctccc                                                   20


<210>  2543
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2543
tcccattcat cctcgcttcc t                                                 21


<210>  2544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2544
tcccattcat cctcgcttcc                                                   20


<210>  2545
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2545
ttcccattca tcctcgcttc c                                                 21


<210>  2546
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2546
gttcccattc atcctcgctt c                                                 21


<210>  2547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2547
ctctcgggtt tggttgggtc                                                   20


<210>  2548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2548
cctcccagtc cttctctcct                                                   20


<210>  2549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2549
agcctcccag tccttctctc                                                   20


<210>  2550
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2550
cctcccagtc cttctctcct a                                                 21


<210>  2551
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2551
agcctcccag tccttctct                                                    19


<210>  2552
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2552
tccttccttc cttccttcct                                                   20


<210>  2553
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2553
cctcttcacc cttgtctggc                                                   20


<210>  2554
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2554
gcctcttcac ccttgtctgg                                                   20


<210>  2555
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2555
cctcttcacc cttgtctggc a                                                 21


<210>  2556
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2556
gggatgtggt gttcttgggt                                                   20


<210>  2557
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2557
ctggtttctg ttgttgtggt                                                   20


<210>  2558
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2558
gtcctcctcc tcctcttcct                                                   20


<210>  2559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2559
tccttcttcc ttcccgtccc                                                   20


<210>  2560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2560
ctcctcctcc tcttcctcct                                                   20


<210>  2561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2561
tcctcctcct cttcctcctc                                                   20


<210>  2562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2562
tcctcctcct cctcttcctc                                                   20


<210>  2563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2563
gtccttctgt atctgtccct                                                   20


<210>  2564
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2564
ccctcagcat ctcttccact c                                                 21


<210>  2565
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2565
gtccttctgt atctgtccct t                                                 21


<210>  2566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2566
gttcgtcctc acagccacct                                                   20


<210>  2567
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2567
cctcctcctc ttcttcctgc t                                                 21


<210>  2568
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2568
cctatcttcc tatctcccac c                                                 21


<210>  2569
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2569
ccctatcttc ctatctccca c                                                 21


<210>  2570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2570
accattctcc accctgccct                                                   20


<210>  2571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2571
ccattctcca ccctgcccta                                                   20


<210>  2572
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2572
accattctcc accctgccct a                                                 21


<210>  2573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2573
cccaagccac tcctccagat                                                   20


<210>  2574
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2574
tccacatagc cacttactcc c                                                 21


<210>  2575
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2575
cccaagccac tcctccagat t                                                 21


<210>  2576
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2576
ccacatagcc acttactccc a                                                 21


<210>  2577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2577
gccacttact cccatcattg                                                   20


<210>  2578
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2578
cctccacctc cttctcatcc t                                                 21


<210>  2579
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2579
tcctccacct ccttctcatc c                                                 21


<210>  2580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2580
cctccacctc cttctcatcc                                                   20


<210>  2581
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2581
ctccacctcc ttctcatcct c                                                 21


<210>  2582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2582
tctctcctcc tcctcctgct                                                   20


<210>  2583
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2583
tctgccgtct gtcacctctc t                                                 21


<210>  2584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2584
tctccaccct tagccgatcc                                                   20


<210>  2585
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2585
tctccaccct tagccgatcc a                                                 21


<210>  2586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2586
gtctccaccc ttagccgatc                                                   20


<210>  2587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2587
ccgtctgtca cctctctcca                                                   20


<210>  2588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2588
gcttctccct gtgtccgtct                                                   20


<210>  2589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2589
actccctgct tgtcccgtct                                                   20


<210>  2590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2590
ctccctgctt gtcccgtctt                                                   20


<210>  2591
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2591
actccctgct tgtcccgtct t                                                 21


<210>  2592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2592
cttctccctg tgtccgtctg                                                   20


<210>  2593
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2593
gtctttctcc tgtgtgtgtc c                                                 21


<210>  2594
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2594
tctttctcct gtgtgtgtcc t                                                 21


<210>  2595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2595
gccttctctc cactctgttg                                                   20


<210>  2596
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2596
gccttctctc cactctgtt                                                    19


<210>  2597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2597
tgccttctct ccactctgtt                                                   20


<210>  2598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2598
gcccttccca cagtccttac                                                   20


<210>  2599
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2599
gcccttccca cagtccttac a                                                 21


<210>  2600
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2600
gcccttccca cattccttac a                                                 21


<210>  2601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2601
gcccttccca cattccttac                                                   20


<210>  2602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2602
cccttcccac attccttaca                                                   20


<210>  2603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2603
gtctgctccc tctgtgtcct                                                   20


<210>  2604
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2604
tgtctgctcc ctctgtgtcc t                                                 21


<210>  2605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2605
tctgctccct ctgtgtcctc                                                   20


<210>  2606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2606
tgtctgctcc ctctgtgtcc                                                   20


<210>  2607
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2607
tctgctccct ctgtgtcctc a                                                 21


