                         SEQUENCE LISTING



<110>  Tabor, Aaron T.

       Harmon, John W.

 

<120>  Compositions and Methods for Genetic Modification of Cells Having

        Cosmetic Function to Enhance Cosmetic Appearance



<130>  12801-346418 (CIP-1)



<150>  61/009,999

<151>  2008-01-05



<150>  61/010,193

<151>  2008-01-04



<150>  11/774,450

<151>  2007-07-06



<150>  60/818,776

<151>  2006-07-06



<160>  24    



<170>  PatentIn version 3.5



<210>  1

<211>  5921

<212>  DNA

<213>  Homo sapiens



<400>  1

agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc       60



atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca      120



tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc      180



acggccaaga ggaaggccaa gtcgagggcc aagacgaaga catcccacca atcacctgcg      240



tacagaacgg cctcaggtac catgaccgag acgtgtggaa acccgagccc tgccggatct      300



gcgtctgcga caacggcaag gtgttgtgcg atgacgtgat ctgtgacgag accaagaact      360



gccccggcgc cgaagtcccc gagggcgagt gctgtcccgt ctgccccgac ggctcagagt      420



cacccaccga ccaagaaacc accggcgtcg agggacccaa gggagacact ggcccccgag      480



gcccaagggg acccgcaggc ccccctggcc gagatggcat ccctggacag cctggacttc      540



ccggaccccc cggacccccc ggacctcccg gaccccctgg cctcggagga aactttgctc      600



cccagctgtc ttatggctat gatgagaaat caaccggagg aatttccgtg cctggcccca      660



tgggtccctc tggtcctcgt ggtctccctg gcccccctgg tgcacctggt ccccaaggct      720



tccaaggtcc ccctggtgag cctggcgagc ctggagcttc aggtcccatg ggtccccgag      780



gtcccccagg tccccctgga aagaatggag atgatgggga agctggaaaa cctggtcgtc      840



ctggtgagcg tgggcctcct gggcctcagg gtgctcgagg attgcccgga acagctggcc      900



tccctggaat gaagggacac agaggtttca gtggtttgga tggtgccaag ggagatgctg      960



gtcctgctgg tcctaagggt gagcctggca gccctggtga aaatggagct cctggtcaga     1020



tgggcccccg tggcctgcct ggtgagagag gtcgccctgg agcccctggc cctgctggtg     1080



ctcgtggaaa tgatggtgct actggtgctg ccgggccccc tggtcccacc ggccccgctg     1140



gtcctcctgg cttccctggt gctgttggtg ctaagggtga agctggtccc caagggcccc     1200



gaggctctga aggtccccag ggtgtgcgtg gtgagcctgg cccccctggc cctgctggtg     1260



ctgctggccc tgctggaaac cctggtgctg atggacagcc tggtgctaaa ggtgccaatg     1320



gtgctcctgg tattgctggt gctcctggct tccctggtgc ccgaggcccc tctggacccc     1380



agggccccgg cggccctcct ggtcccaagg gtaacagcgg tgaacctggt gctcctggca     1440



gcaaaggaga cactggtgct aagggagagc ctggccctgt tggtgttcaa ggaccccctg     1500



gccctgctgg agaggaagga aagcgaggag ctcgaggtga acccggaccc actggcctgc     1560



ccggaccccc tggcgagcgt ggtggacctg gtagccgtgg tttccctggc gcagatggtg     1620



ttgctggtcc caagggtccc gctggtgaac gtggttctcc tggccccgct ggccccaaag     1680



gatctcctgg tgaagctggt cgtcccggtg aagctggtct gcctggtgcc aagggtctga     1740



ctggaagccc tggcagccct ggtcctgatg gcaaaactgg cccccctggt cccgccggtc     1800



aagatggtcg ccccggaccc ccaggcccac ctggtgcccg tggtcaggct ggtgtgatgg     1860



gattccctgg acctaaaggt gctgctggag agcccggcaa ggctggagag cgaggtgttc     1920



ccggaccccc tggcgctgtc ggtcctgctg gcaaagatgg agaggctgga gctcagggac     1980



cccctggccc tgctggtccc gctggcgaga gaggtgaaca aggccctgct ggctcccccg     2040



gattccaggg tctccctggt cctgctggtc ctccaggtga agcaggcaaa cctggtgaac     2100



agggtgttcc tggagacctt ggcgcccctg gcccctctgg agcaagaggc gagagaggtt     2160



tccctggcga gcgtggtgtg caaggtcccc ctggtcctgc tggaccccga ggggccaacg     2220



gtgctcccgg caacgatggt gctaagggtg atgctggtgc ccctggagct cccggtagcc     2280



agggcgcccc tggccttcag ggaatgcctg gtgaacgtgg tgcagctggt cttccagggc     2340



ctaagggtga cagaggtgat gctggtccca aaggtgctga tggctctcct ggcaaagatg     2400



gcgtccgtgg tctgaccggc cccattggtc ctcctggccc tgctggtgcc cctggtgaca     2460



agggtgaaag tggtcccagc ggccctgctg gtcccactgg agctcgtggt gcccccggag     2520



accgtggtga gcctggtccc cccggccctg ctggctttgc tggcccccct ggtgctgacg     2580



gccaacctgg tgctaaaggc gaacctggtg atgctggtgc caaaggcgat gctggtcccc     2640



ctgggcctgc cggacccgct ggaccccctg gccccattgg taatgttggt gctcctggag     2700



ccaaaggtgc tcgcggcagc gctggtcccc ctggtgctac tggtttccct ggtgctgctg     2760



gccgagtcgg tcctcctggc ccctctggaa atgctggacc ccctggccct cctggtcctg     2820



ctggcaaaga aggcggcaaa ggtccccgtg gtgagactgg ccctgctgga cgtcctggtg     2880



aagttggtcc ccctggtccc cctggccctg ctggcgagaa aggatcccct ggtgctgatg     2940



gtcctgctgg tgctcctggt actcccgggc ctcaaggtat tgctggacag cgtggtgtgg     3000



tcggcctgcc tggtcagaga ggagagagag gcttccctgg tcttcctggc ccctctggtg     3060



aacctggcaa acaaggtccc tctggagcaa gtggtgaacg tggtcccccc ggtcccatgg     3120



gcccccctgg attggctgga ccccctggtg aatctggacg tgagggggct cctgctgccg     3180



aaggttcccc tggacgagac ggttctcctg gcgccaaggg tgaccgtggt gagaccggcc     3240



ccgctggacc ccctggtgct cctggtgctc ctggtgcccc tggccccgtt ggccctgctg     3300



gcaagagtgg tgatcgtggt gagactggtc ctgctggtcc cgccggtccc gtcggccccg     3360



tcggcgcccg tggccccgcc ggaccccaag gcccccgtgg tgacaagggt gagacaggcg     3420



aacagggcga cagaggcata aagggtcacc gtggcttctc tggcctccag ggtccccctg     3480



gccctcctgg ctctcctggt gaacaaggtc cctctggagc ctctggtcct gctggtcccc     3540



gaggtccccc tggctctgct ggtgctcctg gcaaagatgg actcaacggt ctccctggcc     3600



ccattgggcc ccctggtcct cgcggtcgca ctggtgatgc tggtcctgtt ggtccccccg     3660



gccctcctgg acctcctggt ccccctggtc ctcccagcgc tggtttcgac ttcagcttcc     3720



tgccccagcc acctcaagag aaggctcacg atggtggccg ctactaccgg gctgatgatg     3780



ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac cctcaagagc ctgagccagc     3840



agatcgagaa catccggagc ccagagggaa gccgcaagaa ccccgcccgc acctgccgtg     3900



acctcaagat gtgccactct gactggaaga gtggagagta ctggattgac cccaaccaag     3960



gctgcaacct ggatgccatc aaagtcttct gcaacatgga gactggtgag acctgcgtgt     4020



accccactca gcccagtgtg gcccagaaga actggtacat cagcaagaac cccaaggaca     4080



agaggcatgt ctggttcggc gagagcatga ccgatggatt ccagttcgag tatggcggcc     4140



agggctccga ccctgccgat gtggccatcc agctgacctt cctgcgcctg atgtccaccg     4200



aggcctccca gaacatcacc taccactgca agaacagcgt ggcctacatg gaccagcaga     4260



ctggcaacct caagaaggcc ctgctcctca agggctccaa cgagatcgag atccgcgccg     4320



agggcaacag ccgcttcacc tacagcgtca ctgtcgatgg ctgcacgagt cacaccggag     4380



cctggggcaa gacagtgatt gaatacaaaa ccaccaagtc ctcccgcctg cccatcatcg     4440



atgtggcccc cttggacgtt ggtgccccag accaggaatt cggcttcgac gttggccctg     4500



tctgcttcct gtaaactccc tccatcccaa cctggctccc tcccacccaa ccaactttcc     4560



ccccaacccg gaaacagaca agcaacccaa actgaacccc cccaaaagcc aaaaaatggg     4620



agacaatttc acatggactt tggaaaatat ttttttcctt tgcattcatc tctcaaactt     4680



agtttttatc tttgaccaac cgaacatgac caaaaaccaa aagtgcattc aaccttacca     4740



aaaaaaaaaa aaaaaaaaaa agaataaata aataagtttt taaaaaagga agcttggtcc     4800



acttgcttga agacccatgc gggggtaagt ccctttctgc ccgttgggtt atgaaacccc     4860



aatgctgccc tttctgctcc tttctccaca ccccccttgg cctcccctcc actccttccc     4920



aaatctgtct ccccagaaga cacaggaaac aatgtattgt ctgcccagca atcaaaggca     4980



atgctcaaac acccaagtgg cccccaccct cagcccgctc ctgcccgccc agcaccccca     5040



ggccctgggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat     5100



ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc     5160



ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg     5220



ggaacgcgtg tcatcccttg tgccgcaggc tgggcgggag agactgttct gttctgttcc     5280



ttgtgtaact gtgttgctga aagactacct cgttcttgtc ttgatgtgtc accggggcaa     5340



ctgcctgggg gcggggatgg gggcagggtg gaagcggctc cccattttta taccaaaggt     5400



gctacatcta tgtgatgggt ggggtgggga gggaatcact ggtgctatag aaattgagat     5460



gcccccccag gccagcaaat gttccttttt gttcaaagtc tatttttatt ccttgatatt     5520



ttttctttct tttttttttt ttttgtggat ggggacttgt gaatttttct aaaggtgcta     5580



tttaacatgg gaggagagcg tgtgcgctcc agcccagccc gctgctcact ttccaccctc     5640



tctccacctg cctctggctt ctcaggcctc tgctctccga cctctctcct ctgaaaccct     5700



cctccacagc tgcagcccat cctcccggct ccctcctagt ctgtcctgcg tcctctgtcc     5760



ccgggtttca gagacaactt cccaaagcac aaagcagttt ttccctaggg gtgggaggaa     5820



gcaaaagact ctgtacctat tttgtatgtg tataataatt tgagatgttt ttaattattt     5880



tgattgctgg aataaagcat gtggaaatga cccaaacata a                         5921





<210>  2

<211>  1464

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 

1               5                   10                  15      





Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 

            20                  25                  30          





Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 

        35                  40                  45              





Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 

    50                  55                  60                  





Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 

65                  70                  75                  80  





Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 

                85                  90                  95      





Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 

            100                 105                 110         





Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 

        115                 120                 125             





Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 

    130                 135                 140                 





Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 

145                 150                 155                 160 





Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 

                165                 170                 175     





Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 

            180                 185                 190         





Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 

        195                 200                 205             





Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 

    210                 215                 220                 





Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 

225                 230                 235                 240 





Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 

                245                 250                 255     





Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 

            260                 265                 270         





Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 

        275                 280                 285             





Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 

    290                 295                 300                 





Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 

305                 310                 315                 320 





Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 

                325                 330                 335     





Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 

            340                 345                 350         





Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 

        355                 360                 365             





Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 

    370                 375                 380                 





Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 

385                 390                 395                 400 





Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 

                405                 410                 415     





Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 

            420                 425                 430         





Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 

        435                 440                 445             





Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 

    450                 455                 460                 





Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 

465                 470                 475                 480 





Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 

                485                 490                 495     





Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 

            500                 505                 510         





Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 

        515                 520                 525             





Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 

    530                 535                 540                 





Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 

545                 550                 555                 560 





Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 

                565                 570                 575     





Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 

            580                 585                 590         





Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 

        595                 600                 605             





Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 

    610                 615                 620                 





Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 

625                 630                 635                 640 





Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 

                645                 650                 655     





Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 

            660                 665                 670         





Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 

        675                 680                 685             





Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 

    690                 695                 700                 





Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 

705                 710                 715                 720 





Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 

                725                 730                 735     





Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 

            740                 745                 750         





Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 

        755                 760                 765             





Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 

    770                 775                 780                 





Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 

785                 790                 795                 800 





Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 

                805                 810                 815     





Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 

            820                 825                 830         





Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 

        835                 840                 845             





Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 

    850                 855                 860                 





Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 

865                 870                 875                 880 





Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 

                885                 890                 895     





Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 

            900                 905                 910         





Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 

        915                 920                 925             





Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 

    930                 935                 940                 





Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 

945                 950                 955                 960 





Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 

                965                 970                 975     





Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 

            980                 985                 990         





Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 

        995                 1000                 1005             





Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Ala Ala  Glu Gly Ser 

    1010                 1015                 1020             





Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 

    1025                 1030                 1035             





Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 

    1040                 1045                 1050             





Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 

    1055                 1060                 1065             





Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 

    1070                 1075                 1080             





Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 

    1085                 1090                 1095             





Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 

    1100                 1105                 1110             





Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 

    1115                 1120                 1125             





Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 

    1130                 1135                 1140             





Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 

    1145                 1150                 1155             





Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 

    1160                 1165                 1170             





Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 

    1175                 1180                 1185             





Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 

    1190                 1195                 1200             





Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 

    1205                 1210                 1215             





Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 

    1220                 1225                 1230             





Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 

    1235                 1240                 1245             





Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 

    1250                 1255                 1260             





Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 

    1265                 1270                 1275             





Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 

    1280                 1285                 1290             





Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 

    1295                 1300                 1305             





Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 

    1310                 1315                 1320             





Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 

    1325                 1330                 1335             





Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 

    1340                 1345                 1350             





Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 

    1355                 1360                 1365             





His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 

    1370                 1375                 1380             





Leu Lys  Lys Ala Leu Leu Leu  Lys Gly Ser Asn Glu  Ile Glu Ile 

    1385                 1390                 1395             





Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 

    1400                 1405                 1410             





Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 

    1415                 1420                 1425             





Tyr Lys  Thr Thr Lys Ser Ser  Arg Leu Pro Ile Ile  Asp Val Ala 

    1430                 1435                 1440             





Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 

    1445                 1450                 1455             





Gly Pro  Val Cys Phe Leu 

    1460                 





<210>  3

<211>  50

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  3

gatcgctagc gccgccacca tgttcagctt tgtggacctc cggctcctgc                  50





<210>  4

<211>  44

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  4

cgataagctt ttacaggaag cagacagggc caacgtcgaa gccg                        44





<210>  5

<211>  2274

<212>  DNA

<213>  Homo sapiens



<400>  5

atggcgggtc tgacggcggc ggccccgcgg cccggagtcc tcctgctcct gctgtccatc       60



ctccacccct ctcggcctgg aggggtccct ggggccattc ctggtggagt tcctggagga      120



gtcttttatc caggggctgg tctcggagcc cttggaggag gagcgctggg gcctggaggc      180



aaacctctta agccagttcc cggagggctt gcgggtgctg gccttggggc agggctcggc      240



gccttccccg cagttacctt tccgggggct ctggtgcctg gtggagtggc tgacgctgct      300



gcagcctata aagctgctaa ggctggcgct gggcttggtg gtgtcccagg agttggtggc      360



ttaggagtgt ctgcaggtgc ggtggttcct cagcctggag ccggagtgaa gcctgggaaa      420



gtgccgggtg tggggctgcc aggtgtatac ccaggtggcg tgctcccagg agctcggttc      480



cccggtgtgg gggtgctccc tggagttccc actggagcag gagttaagcc caaggctcca      540



ggtgtaggtg gagcttttgc tggaatccca ggagttggac cctttggggg accgcaacct      600



ggagtcccac tggggtatcc catcaaggcc cccaagctgc ctggtggcta tggactgccc      660



tacaccacag ggaaactgcc ctatggctat gggcccggag gagtggctgg tgcagcgggc      720



aaggctggtt acccaacagg gacaggggtt ggcccccagg cagcagcagc agcggcagct      780



aaagcagcag caaagttcgg tgctggagca gccggagtcc tccctggtgt tggaggggct      840



ggtgttcctg gcgtgcctgg ggcaattcct ggaattggag gcatcgcagg cgttgggact      900



ccagctgcag ctgcagctgc agcagcagcc gctaaggcag ccaagtatgg agctgctgca      960



ggcttagtgc ctggtgggcc aggctttggc ccgggagtag ttggtgtccc aggagctggc     1020



gttccaggtg ttggtgtccc aggagctggg attccagttg tcccaggtgc tgggatccca     1080



ggtgctgcgg ttccaggggt tgtgtcacca gaagcagctg ctaaggcagc tgcaaaggca     1140



gccaaatacg gggccaggcc cggagtcgga gttggaggca ttcctactta cggggttgga     1200



gctgggggct ttcccggctt tggtgtcgga gtcggaggta tccctggagt cgcaggtgtc     1260



cctagtgtcg gaggtgttcc cggagtcgga ggtgtcccgg gagttggcat ttcccccgaa     1320



gctcaggcag cagctgccgc caaggctgcc aagtacggag tggggacccc agcagctgca     1380



gctgctaaag cagccgccaa agccgcccag tttgggttag ttcctggtgt cggcgtggct     1440



cctggagttg gcgtggctcc tggtgtcggt gtggctcctg gagttggctt ggctcctgga     1500



gttggcgtgg ctcctggagt tggtgtggct cctggcgttg gcgtggctcc cggcattggc     1560



cctggtggag ttgcagctgc agcaaaatcc gctgccaagg tggctgccaa agcccagctc     1620



cgagctgcag ctgggcttgg tgctggcatc cctggacttg gagttggtgt cggcgtccct     1680



ggacttggag ttggtgctgg tgttcctgga cttggagttg gtgctggtgt tcctggcttc     1740



ggggcaggtg cagatgaggg agttaggcgg agcctgtccc ctgagctcag ggaaggagat     1800



ccctcctcct ctcagcacct ccccagcacc ccctcatcac ccagggtacc tggagccctg     1860



gctgccgcta aagcagccaa atatggagca gcagtgcctg gggtccttgg agggctcggg     1920



gctctcggtg gagtaggcat cccaggcggt gtggtgggag ccggacccgc cgccgccgct     1980



gccgcagcca aagctgctgc caaagccgcc cagtttggcc tagtgggagc cgctgggctc     2040



ggaggactcg gagtcggagg gcttggagtt ccaggtgttg ggggccttgg aggtatacct     2100



ccagctgcag ccgctaaagc agctaaatac ggtgctgctg gccttggagg tgtcctaggg     2160



ggtgccgggc agttcccact tggaggagtg gcagcaagac ctggcttcgg attgtctccc     2220



attttcccag gtggggcctg cctggggaaa gcttgtggcc ggaagagaaa atga           2274





<210>  6

<211>  757

<212>  PRT

<213>  Homo sapiens



<400>  6



Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 

1               5                   10                  15      





Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 

            20                  25                  30          





Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 

        35                  40                  45              





Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 

    50                  55                  60                  





Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 

65                  70                  75                  80  





Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 

                85                  90                  95      





Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 

            100                 105                 110         





Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 

        115                 120                 125             





Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 

    130                 135                 140                 





Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 

145                 150                 155                 160 





Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 

                165                 170                 175     





Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 

            180                 185                 190         





Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 

        195                 200                 205             





Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 

    210                 215                 220                 





Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 

225                 230                 235                 240 





Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 

                245                 250                 255     





Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 

            260                 265                 270         





Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 

        275                 280                 285             





Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 

    290                 295                 300                 





Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 

305                 310                 315                 320 





Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 

                325                 330                 335     





Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 

            340                 345                 350         





Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 

        355                 360                 365             





Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 

    370                 375                 380                 





Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 

385                 390                 395                 400 





Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 

                405                 410                 415     





Val Ala Gly Val Pro Ser Val Gly Gly Val Pro Gly Val Gly Gly Val 

            420                 425                 430         





Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 

        435                 440                 445             





Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 

    450                 455                 460                 





Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 

465                 470                 475                 480 





Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 

                485                 490                 495     





Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 

            500                 505                 510         





Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 

        515                 520                 525             





Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 

    530                 535                 540                 





Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 

545                 550                 555                 560 





Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 

                565                 570                 575     





Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 

            580                 585                 590         





Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 

        595                 600                 605             





Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 

    610                 615                 620                 





Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 

625                 630                 635                 640 





Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 

                645                 650                 655     





Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 

            660                 665                 670         





Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 

        675                 680                 685             





Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 

    690                 695                 700                 





Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 

705                 710                 715                 720 





Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 

                725                 730                 735     





Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 

            740                 745                 750         





Gly Arg Lys Arg Lys 

        755         





<210>  7

<211>  49

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  7

gatcgctagc gccgccacca tggcgggtct gacggcggcg gccccgcgg                   49





<210>  8

<211>  44

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  8

gctaagatct tcattttctc ttccggccac aagctttccc cagg                        44





<210>  9

<211>  1984

<212>  DNA

<213>  Homo sapiens



<400>  9

ggatccagag atttagattt tttataagct ttcctgccac cgaaacgggt gtttgggacc       60



tcacgaggcc ctgttcattc ttcgtcgctg cgctccccac tctgtactgg atgcatttac      120



tgacgttgtt gtctccgtcc ccagagtatg aacccccaag gtgactcatg cagctgtggg      180



tgcccggcat acagcatggt gactggaatg gatgagcacc caataaacat ttgttgcagg      240



aatgcaggag gacgggcagg ccagcaagca ggctgcctgg tttttcccac atgggctttt      300



ctgggaaaga agagcttcta tttttggaaa gggctgctat gattgagaaa agttcatggc      360



agcaaaaaaa ggacagacgt cgggagggaa acactcctag ttctcccaga caacacattt      420



tttaaaaaga ctccttcatc tctttaataa taacggtaac gacaatgaca atgatgatta      480



cttatgagtg cggctagtgc cagccactgt gttgtcactg ggcgagtaat gatctcattg      540



gatcttcacg gtgggcgtgc ggggctccag ggacagcctg cgttcctggg ctggctgggt      600



gcagctctct tttcaggaga gaaagctctc ttggaggagc tggaaaggtg cccgactcca      660



gccatgctgg cgctactgtg ttcctgcctg ctcctggcag ccggtgcctc ggacgcctgg      720



acgggcgagg actcggcgga gcccaactct gactcggcgg agtggatccg agacatgtac      780



gccaaggtca cggagatctg gcaggaggtc atgcagcggc gggacgacga cggcacgctc      840



cacgccgcct gccaggtgca gccgtcggcc acgctggacg ccgcgcagcc ccgggtgacc      900



ggcgtcgtcc tcttccggca gcttgcgccc cgcgccaagc tcgacgcctt cttcgccctg      960



gagggcttcc cgaccgagcc gaacagctcc agccgcgcca tccacgtgca ccagttcggg     1020



gacctgagcc agggctgcga gtccaccggg ccccactaca acccgctggc cgtgccgcac     1080



ccgcagcacc cgggcgactt cggcaacttc gcggtccgcg acggcagcct ctggaggtac     1140



cgcgccggcc tggccgcctc gctcgcgggc ccgcactcca tcgtgggccg ggccgtggtc     1200



gtccacgctg gcgaggacga cctgggccgc ggcggcaacc aggccagcgt ggagaacggg     1260



aacgcgggcc ggcggctggc ctgctgcgtg gtgggcgtgt gcgggcccgg gctctgggag     1320



cgccaggcgc gggagcactc agagcgcaag aagcggcggc gcgagagcga gtgcaaggcc     1380



gcctgagcgc ggcccccacc cggcggcggc cagggacccc cgaggccccc ctctgccttt     1440



gagcttctcc tctgctccaa cagacacctt ccactctgag gtctcacctt cgcctctgct     1500



gaagtctccc cgcagccctc tccacccaga ggtctcccta taccgagacc caccatcctt     1560



ccatcctgag gaccgcccca accctcggag ccccccactc agtaggtctg aaggcctcca     1620



tttgtaccga aacaccccgc tcacgctgac agcctcctag gctccctgag gtacctttcc     1680



acccagaccc tccttcccca ccccataagc cctgagactc ccgcctttga cctgacgatc     1740



ttcccccttc ccgccttcag gttcctccta ggcgctcaga ggccgctctg gggggttgcc     1800



tcgagtcccc ccacccctcc ccacccacca ccgctcccgc ggcaagccag cccgtgcaac     1860



ggaagccagg ccaactgccc cgcgtcttca gctgtttcgc atccaccgcc accccactga     1920



gagctgctcc tttgggggaa tgtttggcaa cctttgtgtt acagattaaa aattcagcaa     1980



ttca                                                                  1984





<210>  10

<211>  240

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 

1               5                   10                  15      





Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala 

            20                  25                  30          





Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu 

        35                  40                  45              





Val Met Gln Arg Arg Asp Asp Asp Gly Thr Leu His Ala Ala Cys Gln 

    50                  55                  60                  





Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly 

65                  70                  75                  80  





Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe 

                85                  90                  95      





Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala 

            100                 105                 110         





Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr 

        115                 120                 125             





Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly 

    130                 135                 140                 





Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg 

145                 150                 155                 160 





Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg 

                165                 170                 175     





Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn 

            180                 185                 190         





Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys 

        195                 200                 205             





Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu 

    210                 215                 220                 





His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala 

225                 230                 235                 240 





<210>  11

<211>  56

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  11

gatcgctagc gccgccacca tgctggcgct actgtgttcc tgcctgctcc tggcag           56





<210>  12

<211>  46

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  12

cgataagctt tcaggcggcc ttgcactcgc tctcgcgccg ccgctt                      46





<210>  13

<211>  931

<212>  DNA

<213>  Homo sapiens



<400>  13

tttcgtcggc ccgccccttg gcttctgcac tgatggtggg tggatgagta atgcatccag       60



gaagcctgga ggcctgtggt ttccgcaccc gctgccaccc ccgcccctag cgtggacatt      120



tatcctctag cgctcaggcc ctgccgccat cgccgcagat ccagcgccca gagagacacc      180



agagaaccca ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg      240



ctgatagccc ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc      300



aattccgacc tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc      360



ttataccagc gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg      420



gatgccgctg acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc      480



cacaggtccc acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc      540



ttgcacatca ctacctgcag ttttgtggct ccctggaaca gcctgagctt agctcagcgc      600



cggggcttca ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta      660



tccatcccct gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa      720



ggctctgaaa agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg      780



tgcacctggc agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaagctgaa      840



gcctgcacag tgtccaccct gttcccactc ccatctttct tccggacaat gaaataaaga      900



gttaccaccc agcagaaaaa aaaaaaaaaa a                                     931





<210>  14

<211>  207

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 

1               5                   10                  15      





Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 

            20                  25                  30          





Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 

        35                  40                  45              





Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 

    50                  55                  60                  





Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 

65                  70                  75                  80  





Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 

                85                  90                  95      





His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 

            100                 105                 110         





Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 

        115                 120                 125             





Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 

    130                 135                 140                 





Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 

145                 150                 155                 160 





Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 

                165                 170                 175     





Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 

            180                 185                 190         





Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 

        195                 200                 205         





<210>  15

<211>  55

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  15

gatcgctagc gccgccacca tggccccctt tgagcccctg gcttctggca tcctg            55





<210>  16

<211>  46

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  16

cgataagctt tcaggctatc tgggaccgca gggactgcca ggtgca                      46





<210>  17

<211>  4101

<212>  DNA

<213>  Homo sapiens



<400>  17

atgctcagct ttgtggatac gcggactttg ttgctgcttg cagtaacctt atgcctagca       60



acatgccaat ctttacaaga ggaaactgta agaaagggcc cagccggaga tagaggacca      120



cgtggagaaa ggggtccacc aggcccccca ggcagagatg gtgaagatgg tcccacaggc      180



cctcctggtc cacctggtcc tcctggcccc cctggtctcg gtgggaactt tgctgctcag      240



tatgatggaa aaggagttgg acttggccct ggaccaatgg gcttaatggg acctagaggc      300



ccacctggtg cagctggagc cccaggccct caaggtttcc aaggacctgc tggtgagcct      360



ggtgaacctg gtcaaactgg tcctgcaggt gctcgtggtc cagctggccc tcctggcaag      420



gctggtgaag atggtcaccc tggaaaaccc ggacgacctg gtgagagagg agttgttgga      480



ccacagggtg ctcgtggttt ccctggaact cctggacttc ctggcttcaa aggcattagg      540



ggacacaatg gtctggatgg attgaaggga cagcccggtg ctcctggtgt gaagggtgaa      600



cctggtgccc ctggtgaaaa tggaactcca ggtcaaacag gagcccgtgg gcttcctggt      660



gagagaggac gtgttggtgc ccctggccca gctggtgccc gtggcagtga tggaagtgtg      720



ggtcccgtgg gtcctgctgg tcccattggg tctgctggcc ctccaggctt cccaggtgcc      780



cctggcccca agggtgaaat tggagctgtt ggtaacgctg gtcctgctgg tcccgccggt      840



ccccgtggtg aagtgggtct tccaggcctc tccggccccg ttggacctcc tggtaatcct      900



ggagcaaacg gccttactgg tgccaagggt gctgctggcc ttcccggcgt tgctggggct      960



cccggcctcc ctggaccccg cggtattcct ggccctgttg gtgctgccgg tgctactggt     1020



gccagaggac ttgttggtga gcctggtcca gctggctcca aaggagagag cggtaacaag     1080



ggtgagcccg gctctgctgg gccccaaggt cctcctggtc ccagtggtga agaaggaaag     1140



agaggcccta atggggaagc tggatctgcc ggccctccag gacctcctgg gctgagaggt     1200



agtcctggtt ctcgtggtct tcctggagct gatggcagag ctggcgtcat gggccctcct     1260



ggtagtcgtg gtgcaagtgg ccctgctgga gtccgaggac ctaatggaga tgctggtcgc     1320



cctggggagc ctggtctcat gggacccaga ggtcttcctg gttcccctgg aaatatcggc     1380



cccgctggaa aagaaggtcc tgtcggcctc cctggcatcg acggcaggcc tggcccaatt     1440



ggcccagctg gagcaagagg agagcctggc aacattggat tccctggacc caaaggcccc     1500



actggtgatc ctggcaaaaa cggtgataaa ggtcatgctg gtcttgctgg tgctcggggt     1560



gctccaggtc ctgatggaaa caatggtgct cagggacctc ctggaccaca gggtgttcaa     1620



ggtggaaaag gtgaacaggg tccccctggt cctccaggct tccagggtct gcctggcccc     1680



tcaggtcccg ctggtgaagt tggcaaacca ggagaaaggg gtctccatgg tgagtttggt     1740



ctccctggtc ctgctggtcc aagaggggaa cgcggtcccc caggtgagag tggtgctgcc     1800



ggtcctactg gtcctattgg aagccgaggt ccttctggac ccccagggcc tgatggaaac     1860



aagggtgaac ctggtgtggt tggtgctgtg ggcactgctg gtccatctgg tcctagtgga     1920



ctcccaggag agaggggtgc tgctggcata cctggaggca agggagaaaa gggtgaacct     1980



ggtctcagag gtgaaattgg taaccctggc agagatggtg ctcgtggtgc tcctggtgct     2040



gtaggtgccc ctggtcctgc tggagccaca ggtgaccggg gcgaagctgg ggctgctggt     2100



cctgctggtc ctgctggtcc tcggggaagc cctggtgaac gtggtgaggt cggtcctgct     2160



ggccccaatg gatttgctgg tcctgctggt gctgctggtc aacctggtgc taaaggagaa     2220



agaggagcca aagggcctaa gggtgaaaac ggtgttgttg gtcccacagg ccccgttgga     2280



gctgctggcc cagctggtcc aaatggtccc cccggtcctg ctggaagtcg tggtgatgga     2340



ggcccccctg gtatgactgg tttccctggt gctgctggac ggactggtcc cccaggaccc     2400



tctggtattt ctggccctcc tggtccccct ggtcctgctg ggaaagaagg gcttcgtggt     2460



cctcgtggtg accaaggtcc agttggccga actggagaag taggtgcagt tggtccccct     2520



ggcttcgctg gtgagaaggg tccctctgga gaggctggta ctgctggacc tcctggcact     2580



ccaggtcctc agggtcttct tggtgctcct ggtattctgg gtctccctgg ctcgagaggt     2640



gaacgtggtc taccaggtgt tgctggtgct gtgggtgaac ctggtcctct tggcattgcc     2700



ggccctcctg gggcccgtgg tcctcctggt gctgtgggta gtcctggagt caacggtgct     2760



cctggtgaag ctggtcgtga tggcaaccct gggaacgatg gtcccccagg tcgcgatggt     2820



caacccggac acaagggaga gcgcggttac cctggcaata ttggtcccgt tggtgctgca     2880



ggtgcacctg gtcctcatgg ccccgtgggt cctgctggca aacatggaaa ccgtggtgaa     2940



actggtcctt ctggtcctgt tggtcctgct ggtgctgttg gcccaagagg tcctagtggc     3000



ccacaaggca ttcgtggcga taagggagag cccggtgaaa aggggcccag aggtcttcct     3060



ggcttaaagg gacacaatgg attgcaaggt ctgcctggta tcgctggtca ccatggtgat     3120



caaggtgctc ctggctccgt gggtcctgct ggtcctaggg gccctgctgg tccttctggc     3180



cctgctggaa aagatggtcg cactggacat cctggtacag ttggacctgc tggcattcga     3240



ggccctcagg gtcaccaagg ccctgctggc ccccctggtc cccctggccc tcctggacct     3300



ccaggtgtaa gcggtggtgg ttatgacttt ggttacgatg gagacttcta cagggctgac     3360



cagcctcgct cagcaccttc tctcagaccc aaggactatg aagttgatgc tactctgaag     3420



tctctcaaca accagattga gacccttctt actcctgaag gctctagaaa gaacccagct     3480



cgcacatgcc gtgacttgag actcagccac ccagagtgga gcagtggtta ctactggatt     3540



gaccctaacc aaggatgcac tatggatgct atcaaagtat actgtgattt ctctactggc     3600



gaaacctgta tccgggccca acctgaaaac atcccagcca agaactggta taggagctcc     3660



aaggacaaga aacacgtctg gctaggagaa actatcaatg ctggcagcca gtttgaatat     3720



aatgtagaag gagtgacttc caaggaaatg gctacccaac ttgccttcat gcgcctgctg     3780



gccaactatg cctctcagaa catcacctac cactgcaaga acagcattgc atacatggat     3840



gaggagactg gcaacctgaa aaaggctgtc attctacagg gctctaatga tgttgaactt     3900



gttgctgagg gcaacagcag gttcacttac actgttcttg tagatggctg ctctaaaaag     3960



acaaatgaat ggggaaagac aatcattgaa tacaaaacaa ataagccatc acgcctgccc     4020



ttccttgata ttgcaccttt ggacatcggt ggtgctgacc aggaattctt tgtggacatt     4080



ggcccagtct gtttcaaata a                                               4101





<210>  18

<211>  1366

<212>  PRT

<213>  Homo sapiens



<400>  18



Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 

1               5                   10                  15      





Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 

            20                  25                  30          





Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 

        35                  40                  45              





Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 

    50                  55                  60                  





Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 

65                  70                  75                  80  





Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 

                85                  90                  95      





Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 

            100                 105                 110         





Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 

        115                 120                 125             





Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 

    130                 135                 140                 





Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 

145                 150                 155                 160 





Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 

                165                 170                 175     





Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 

            180                 185                 190         





Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 

        195                 200                 205             





Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 

    210                 215                 220                 





Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 

225                 230                 235                 240 





Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 

                245                 250                 255     





Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 

            260                 265                 270         





Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 

        275                 280                 285             





Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 

    290                 295                 300                 





Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 

305                 310                 315                 320 





Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 

                325                 330                 335     





Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 

            340                 345                 350         





Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 

        355                 360                 365             





Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 

    370                 375                 380                 





Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 

385                 390                 395                 400 





Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 

                405                 410                 415     





Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 

            420                 425                 430         





Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 

        435                 440                 445             





Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 

    450                 455                 460                 





Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 

465                 470                 475                 480 





Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 

                485                 490                 495     





Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 

            500                 505                 510         





Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 

        515                 520                 525             





Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 

    530                 535                 540                 





Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 

545                 550                 555                 560 





Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 

                565                 570                 575     





Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 

            580                 585                 590         





Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 

        595                 600                 605             





Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 

    610                 615                 620                 





Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 

625                 630                 635                 640 





Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 

                645                 650                 655     





Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 

            660                 665                 670         





Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 

        675                 680                 685             





Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 

    690                 695                 700                 





Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 

705                 710                 715                 720 





Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 

                725                 730                 735     





Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 

            740                 745                 750         





Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 

        755                 760                 765             





Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 

    770                 775                 780                 





Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 

785                 790                 795                 800 





Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 

                805                 810                 815     





Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 

            820                 825                 830         





Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 

        835                 840                 845             





Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 

    850                 855                 860                 





Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 

865                 870                 875                 880 





Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 

                885                 890                 895     





Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 

            900                 905                 910         





Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 

        915                 920                 925             





Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 

    930                 935                 940                 





Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 

945                 950                 955                 960 





Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 

                965                 970                 975     





Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 

            980                 985                 990         





Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 

        995                 1000                 1005             





Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 

    1010                 1015                 1020             





Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 

    1025                 1030                 1035             





Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 

    1040                 1045                 1050             





Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 

    1055                 1060                 1065             





Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 

    1070                 1075                 1080             





Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 

    1085                 1090                 1095             





Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 

    1100                 1105                 1110             





Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 

    1115                 1120                 1125             





Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 

    1130                 1135                 1140             





Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 

    1145                 1150                 1155             





Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 

    1160                 1165                 1170             





Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 

    1175                 1180                 1185             





Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 

    1190                 1195                 1200             





Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 

    1205                 1210                 1215             





Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 

    1220                 1225                 1230             





Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 

    1235                 1240                 1245             





Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 

    1250                 1255                 1260             





Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 

    1265                 1270                 1275             





Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 

    1280                 1285                 1290             





Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 

    1295                 1300                 1305             





Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 

    1310                 1315                 1320             





Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 

    1325                 1330                 1335             





Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 

    1340                 1345                 1350             





Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 

    1355                 1360                 1365     





<210>  19

<211>  58

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  19

gatcgctagc gccgccacca tgctcagctt tgtggatacg cggactttgt tgctgctt         58





<210>  20

<211>  51

<212>  DNA

<213>  Artificial



<220>

<223>  Artificial sequence = synthetic construct



<400>  20

cgataagctt ttatttgaaa cagactgggc caatgtccac aaagaattcc t                51





<210>  21

<211>  46

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Artificial sequence = synthetic construct



<400>  21

gatcgctagc gccgccacca tgcacaaatg gatactgaca tggatc                      46





<210>  22

<211>  50

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Artificial sequence = artificial construct



<400>  22

cgataagctt ttaagttatt gccataggaa gaaagtgggc tgttttttgt                  50





<210>  23

<211>  194

<212>  PRT

<213>  Homo sapiens



<400>  23



Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 

1               5                   10                  15      





Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 

            20                  25                  30          





Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 

        35                  40                  45              





Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 

    50                  55                  60                  





Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 

65                  70                  75                  80  





Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 

                85                  90                  95      





Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 

            100                 105                 110         





Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 

        115                 120                 125             





Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 

    130                 135                 140                 





Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 

145                 150                 155                 160 





Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 

                165                 170                 175     





Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 

            180                 185                 190         





Ile Thr 

        





<210>  24

<211>  1440

<212>  DNA

<213>  Homo sapiens



<400>  24

acgcgctcac acacagagag aaaatccttc tgcctgttga tttatggaaa caattatgat       60



tctgctggag aacttttcag ctgagaaata gtttgtagct acagtagaaa ggctcaagtt      120



gcaccaggca gacaacagac atggaattct tatatatcca gctgttagca acaaaacaaa      180



agtcaaatag caaacagcgt cacagcaact gaacttacta cgaactgttt ttatgaggat      240



ttatcaacag agttatttaa ggaggaatcc tgtgttgtta tcaggaacta aaaggataag      300



gctaacaatt tggaaagagc aagtactctt tcttaaatca atctacaatt cacagatagg      360



aagaggtcaa tgacctagga gtaacaatca actcaagatt cattttcatt atgttattca      420



tgaacacccg gagcactaca ctataatgca caaatggata ctgacatgga tcctgccaac      480



tttgctctac agatcatgct ttcacattat ctgtctagtg ggtactatat ctttagcttg      540



caatgacatg actccagagc aaatggctac aaatgtgaac tgttccagcc ctgagcgaca      600



cacaagaagt tatgattaca tggaaggagg ggatataaga gtgagaagac tcttctgtcg      660



aacacagtgg tacctgagga tcgataaaag aggcaaagta aaagggaccc aagagatgaa      720



gaataattac aatatcatgg aaatcaggac agtggcagtt ggaattgtgg caatcaaagg      780



ggtggaaagt gaattctatc ttgcaatgaa caaggaagga aaactctatg caaagaaaga      840



atgcaatgaa gattgtaact tcaaagaact aattctggaa aaccattaca acacatatgc      900



atcagctaaa tggacacaca acggagggga aatgtttgtt gccttaaatc aaaaggggat      960



tcctgtaaga ggaaaaaaaa cgaagaaaga acaaaaaaca gcccactttc ttcctatggc     1020



aataacttaa ttgcatatgg tatataaaga acccagttcc agcagggaga tttctttaag     1080



tggactgttt tctttcttct caaaattttc tttcctttta ttttttagta atcaagaaag     1140



gctggaaaaa ctactgaaaa actgatcaag ctggacttgt gcatttatgt ttgttttaag     1200



acactgcatt aaagaaagat ttgaaaagta tacacaaaaa tcagatttag taactaaagg     1260



ttgtaaaaaa ttgtaaaact ggttgtacaa tcatgatgtt agtaacagta atttttttct     1320



taaattaatt tacccttaag agtatgttag atttgattat ctgataatga ttatttaaat     1380



attcctatct gcttataaaa tggctgctat aataataata atacagatgt tgttatataa     1440





