                         SEQUENCE LISTING

<110>  Tabor, Aaron T.
       Harmon, John W.
 
<120>  Compositions and Methods for Genetic Modification of Cells Having
        Cosmetic Function to Enhance Cosmetic Appearance

<130>  12801-346418 (CIP-1)

<140>  PCT/US10/42051
<141>  2010-07-15

<150>  61/009,999
<151>  2008-01-05

<150>  61/010,193
<151>  2008-01-04

<150>  11/774,450
<151>  2007-07-06

<150>  60/818,776
<151>  2006-07-06

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  5921
<212>  DNA
<213>  Homo sapiens

<400>  1
agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc       60

atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca      120

tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc      180

acggccaaga ggaaggccaa gtcgagggcc aagacgaaga catcccacca atcacctgcg      240

tacagaacgg cctcaggtac catgaccgag acgtgtggaa acccgagccc tgccggatct      300

gcgtctgcga caacggcaag gtgttgtgcg atgacgtgat ctgtgacgag accaagaact      360

gccccggcgc cgaagtcccc gagggcgagt gctgtcccgt ctgccccgac ggctcagagt      420

cacccaccga ccaagaaacc accggcgtcg agggacccaa gggagacact ggcccccgag      480

gcccaagggg acccgcaggc ccccctggcc gagatggcat ccctggacag cctggacttc      540

ccggaccccc cggacccccc ggacctcccg gaccccctgg cctcggagga aactttgctc      600

cccagctgtc ttatggctat gatgagaaat caaccggagg aatttccgtg cctggcccca      660

tgggtccctc tggtcctcgt ggtctccctg gcccccctgg tgcacctggt ccccaaggct      720

tccaaggtcc ccctggtgag cctggcgagc ctggagcttc aggtcccatg ggtccccgag      780

gtcccccagg tccccctgga aagaatggag atgatgggga agctggaaaa cctggtcgtc      840

ctggtgagcg tgggcctcct gggcctcagg gtgctcgagg attgcccgga acagctggcc      900

tccctggaat gaagggacac agaggtttca gtggtttgga tggtgccaag ggagatgctg      960

gtcctgctgg tcctaagggt gagcctggca gccctggtga aaatggagct cctggtcaga     1020

tgggcccccg tggcctgcct ggtgagagag gtcgccctgg agcccctggc cctgctggtg     1080

ctcgtggaaa tgatggtgct actggtgctg ccgggccccc tggtcccacc ggccccgctg     1140

gtcctcctgg cttccctggt gctgttggtg ctaagggtga agctggtccc caagggcccc     1200

gaggctctga aggtccccag ggtgtgcgtg gtgagcctgg cccccctggc cctgctggtg     1260

ctgctggccc tgctggaaac cctggtgctg atggacagcc tggtgctaaa ggtgccaatg     1320

gtgctcctgg tattgctggt gctcctggct tccctggtgc ccgaggcccc tctggacccc     1380

agggccccgg cggccctcct ggtcccaagg gtaacagcgg tgaacctggt gctcctggca     1440

gcaaaggaga cactggtgct aagggagagc ctggccctgt tggtgttcaa ggaccccctg     1500

gccctgctgg agaggaagga aagcgaggag ctcgaggtga acccggaccc actggcctgc     1560

ccggaccccc tggcgagcgt ggtggacctg gtagccgtgg tttccctggc gcagatggtg     1620

ttgctggtcc caagggtccc gctggtgaac gtggttctcc tggccccgct ggccccaaag     1680

gatctcctgg tgaagctggt cgtcccggtg aagctggtct gcctggtgcc aagggtctga     1740

ctggaagccc tggcagccct ggtcctgatg gcaaaactgg cccccctggt cccgccggtc     1800

aagatggtcg ccccggaccc ccaggcccac ctggtgcccg tggtcaggct ggtgtgatgg     1860

gattccctgg acctaaaggt gctgctggag agcccggcaa ggctggagag cgaggtgttc     1920

ccggaccccc tggcgctgtc ggtcctgctg gcaaagatgg agaggctgga gctcagggac     1980

cccctggccc tgctggtccc gctggcgaga gaggtgaaca aggccctgct ggctcccccg     2040

gattccaggg tctccctggt cctgctggtc ctccaggtga agcaggcaaa cctggtgaac     2100

agggtgttcc tggagacctt ggcgcccctg gcccctctgg agcaagaggc gagagaggtt     2160

tccctggcga gcgtggtgtg caaggtcccc ctggtcctgc tggaccccga ggggccaacg     2220

gtgctcccgg caacgatggt gctaagggtg atgctggtgc ccctggagct cccggtagcc     2280

agggcgcccc tggccttcag ggaatgcctg gtgaacgtgg tgcagctggt cttccagggc     2340

ctaagggtga cagaggtgat gctggtccca aaggtgctga tggctctcct ggcaaagatg     2400

gcgtccgtgg tctgaccggc cccattggtc ctcctggccc tgctggtgcc cctggtgaca     2460

agggtgaaag tggtcccagc ggccctgctg gtcccactgg agctcgtggt gcccccggag     2520

accgtggtga gcctggtccc cccggccctg ctggctttgc tggcccccct ggtgctgacg     2580

gccaacctgg tgctaaaggc gaacctggtg atgctggtgc caaaggcgat gctggtcccc     2640

ctgggcctgc cggacccgct ggaccccctg gccccattgg taatgttggt gctcctggag     2700

ccaaaggtgc tcgcggcagc gctggtcccc ctggtgctac tggtttccct ggtgctgctg     2760

gccgagtcgg tcctcctggc ccctctggaa atgctggacc ccctggccct cctggtcctg     2820

ctggcaaaga aggcggcaaa ggtccccgtg gtgagactgg ccctgctgga cgtcctggtg     2880

aagttggtcc ccctggtccc cctggccctg ctggcgagaa aggatcccct ggtgctgatg     2940

gtcctgctgg tgctcctggt actcccgggc ctcaaggtat tgctggacag cgtggtgtgg     3000

tcggcctgcc tggtcagaga ggagagagag gcttccctgg tcttcctggc ccctctggtg     3060

aacctggcaa acaaggtccc tctggagcaa gtggtgaacg tggtcccccc ggtcccatgg     3120

gcccccctgg attggctgga ccccctggtg aatctggacg tgagggggct cctgctgccg     3180

aaggttcccc tggacgagac ggttctcctg gcgccaaggg tgaccgtggt gagaccggcc     3240

ccgctggacc ccctggtgct cctggtgctc ctggtgcccc tggccccgtt ggccctgctg     3300

gcaagagtgg tgatcgtggt gagactggtc ctgctggtcc cgccggtccc gtcggccccg     3360

tcggcgcccg tggccccgcc ggaccccaag gcccccgtgg tgacaagggt gagacaggcg     3420

aacagggcga cagaggcata aagggtcacc gtggcttctc tggcctccag ggtccccctg     3480

gccctcctgg ctctcctggt gaacaaggtc cctctggagc ctctggtcct gctggtcccc     3540

gaggtccccc tggctctgct ggtgctcctg gcaaagatgg actcaacggt ctccctggcc     3600

ccattgggcc ccctggtcct cgcggtcgca ctggtgatgc tggtcctgtt ggtccccccg     3660

gccctcctgg acctcctggt ccccctggtc ctcccagcgc tggtttcgac ttcagcttcc     3720

tgccccagcc acctcaagag aaggctcacg atggtggccg ctactaccgg gctgatgatg     3780

ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac cctcaagagc ctgagccagc     3840

agatcgagaa catccggagc ccagagggaa gccgcaagaa ccccgcccgc acctgccgtg     3900

acctcaagat gtgccactct gactggaaga gtggagagta ctggattgac cccaaccaag     3960

gctgcaacct ggatgccatc aaagtcttct gcaacatgga gactggtgag acctgcgtgt     4020

accccactca gcccagtgtg gcccagaaga actggtacat cagcaagaac cccaaggaca     4080

agaggcatgt ctggttcggc gagagcatga ccgatggatt ccagttcgag tatggcggcc     4140

agggctccga ccctgccgat gtggccatcc agctgacctt cctgcgcctg atgtccaccg     4200

aggcctccca gaacatcacc taccactgca agaacagcgt ggcctacatg gaccagcaga     4260

ctggcaacct caagaaggcc ctgctcctca agggctccaa cgagatcgag atccgcgccg     4320

agggcaacag ccgcttcacc tacagcgtca ctgtcgatgg ctgcacgagt cacaccggag     4380

cctggggcaa gacagtgatt gaatacaaaa ccaccaagtc ctcccgcctg cccatcatcg     4440

atgtggcccc cttggacgtt ggtgccccag accaggaatt cggcttcgac gttggccctg     4500

tctgcttcct gtaaactccc tccatcccaa cctggctccc tcccacccaa ccaactttcc     4560

ccccaacccg gaaacagaca agcaacccaa actgaacccc cccaaaagcc aaaaaatggg     4620

agacaatttc acatggactt tggaaaatat ttttttcctt tgcattcatc tctcaaactt     4680

agtttttatc tttgaccaac cgaacatgac caaaaaccaa aagtgcattc aaccttacca     4740

aaaaaaaaaa aaaaaaaaaa agaataaata aataagtttt taaaaaagga agcttggtcc     4800

acttgcttga agacccatgc gggggtaagt ccctttctgc ccgttgggtt atgaaacccc     4860

aatgctgccc tttctgctcc tttctccaca ccccccttgg cctcccctcc actccttccc     4920

aaatctgtct ccccagaaga cacaggaaac aatgtattgt ctgcccagca atcaaaggca     4980

atgctcaaac acccaagtgg cccccaccct cagcccgctc ctgcccgccc agcaccccca     5040

ggccctgggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat     5100

ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc     5160

ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg     5220

ggaacgcgtg tcatcccttg tgccgcaggc tgggcgggag agactgttct gttctgttcc     5280

ttgtgtaact gtgttgctga aagactacct cgttcttgtc ttgatgtgtc accggggcaa     5340

ctgcctgggg gcggggatgg gggcagggtg gaagcggctc cccattttta taccaaaggt     5400

gctacatcta tgtgatgggt ggggtgggga gggaatcact ggtgctatag aaattgagat     5460

gcccccccag gccagcaaat gttccttttt gttcaaagtc tatttttatt ccttgatatt     5520

ttttctttct tttttttttt ttttgtggat ggggacttgt gaatttttct aaaggtgcta     5580

tttaacatgg gaggagagcg tgtgcgctcc agcccagccc gctgctcact ttccaccctc     5640

tctccacctg cctctggctt ctcaggcctc tgctctccga cctctctcct ctgaaaccct     5700

cctccacagc tgcagcccat cctcccggct ccctcctagt ctgtcctgcg tcctctgtcc     5760

ccgggtttca gagacaactt cccaaagcac aaagcagttt ttccctaggg gtgggaggaa     5820

gcaaaagact ctgtacctat tttgtatgtg tataataatt tgagatgttt ttaattattt     5880

tgattgctgg aataaagcat gtggaaatga cccaaacata a                         5921


<210>  2
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Ala Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Lys Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Ser Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  3
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  3
gatcgctagc gccgccacca tgttcagctt tgtggacctc cggctcctgc                  50


<210>  4
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  4
cgataagctt ttacaggaag cagacagggc caacgtcgaa gccg                        44


<210>  5
<211>  2274
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcgggtc tgacggcggc ggccccgcgg cccggagtcc tcctgctcct gctgtccatc       60

ctccacccct ctcggcctgg aggggtccct ggggccattc ctggtggagt tcctggagga      120

gtcttttatc caggggctgg tctcggagcc cttggaggag gagcgctggg gcctggaggc      180

aaacctctta agccagttcc cggagggctt gcgggtgctg gccttggggc agggctcggc      240

gccttccccg cagttacctt tccgggggct ctggtgcctg gtggagtggc tgacgctgct      300

gcagcctata aagctgctaa ggctggcgct gggcttggtg gtgtcccagg agttggtggc      360

ttaggagtgt ctgcaggtgc ggtggttcct cagcctggag ccggagtgaa gcctgggaaa      420

gtgccgggtg tggggctgcc aggtgtatac ccaggtggcg tgctcccagg agctcggttc      480

cccggtgtgg gggtgctccc tggagttccc actggagcag gagttaagcc caaggctcca      540

ggtgtaggtg gagcttttgc tggaatccca ggagttggac cctttggggg accgcaacct      600

ggagtcccac tggggtatcc catcaaggcc cccaagctgc ctggtggcta tggactgccc      660

tacaccacag ggaaactgcc ctatggctat gggcccggag gagtggctgg tgcagcgggc      720

aaggctggtt acccaacagg gacaggggtt ggcccccagg cagcagcagc agcggcagct      780

aaagcagcag caaagttcgg tgctggagca gccggagtcc tccctggtgt tggaggggct      840

ggtgttcctg gcgtgcctgg ggcaattcct ggaattggag gcatcgcagg cgttgggact      900

ccagctgcag ctgcagctgc agcagcagcc gctaaggcag ccaagtatgg agctgctgca      960

ggcttagtgc ctggtgggcc aggctttggc ccgggagtag ttggtgtccc aggagctggc     1020

gttccaggtg ttggtgtccc aggagctggg attccagttg tcccaggtgc tgggatccca     1080

ggtgctgcgg ttccaggggt tgtgtcacca gaagcagctg ctaaggcagc tgcaaaggca     1140

gccaaatacg gggccaggcc cggagtcgga gttggaggca ttcctactta cggggttgga     1200

gctgggggct ttcccggctt tggtgtcgga gtcggaggta tccctggagt cgcaggtgtc     1260

cctagtgtcg gaggtgttcc cggagtcgga ggtgtcccgg gagttggcat ttcccccgaa     1320

gctcaggcag cagctgccgc caaggctgcc aagtacggag tggggacccc agcagctgca     1380

gctgctaaag cagccgccaa agccgcccag tttgggttag ttcctggtgt cggcgtggct     1440

cctggagttg gcgtggctcc tggtgtcggt gtggctcctg gagttggctt ggctcctgga     1500

gttggcgtgg ctcctggagt tggtgtggct cctggcgttg gcgtggctcc cggcattggc     1560

cctggtggag ttgcagctgc agcaaaatcc gctgccaagg tggctgccaa agcccagctc     1620

cgagctgcag ctgggcttgg tgctggcatc cctggacttg gagttggtgt cggcgtccct     1680

ggacttggag ttggtgctgg tgttcctgga cttggagttg gtgctggtgt tcctggcttc     1740

ggggcaggtg cagatgaggg agttaggcgg agcctgtccc ctgagctcag ggaaggagat     1800

ccctcctcct ctcagcacct ccccagcacc ccctcatcac ccagggtacc tggagccctg     1860

gctgccgcta aagcagccaa atatggagca gcagtgcctg gggtccttgg agggctcggg     1920

gctctcggtg gagtaggcat cccaggcggt gtggtgggag ccggacccgc cgccgccgct     1980

gccgcagcca aagctgctgc caaagccgcc cagtttggcc tagtgggagc cgctgggctc     2040

ggaggactcg gagtcggagg gcttggagtt ccaggtgttg ggggccttgg aggtatacct     2100

ccagctgcag ccgctaaagc agctaaatac ggtgctgctg gccttggagg tgtcctaggg     2160

ggtgccgggc agttcccact tggaggagtg gcagcaagac ctggcttcgg attgtctccc     2220

attttcccag gtggggcctg cctggggaaa gcttgtggcc ggaagagaaa atga           2274


<210>  6
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Ser Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 
            580                 585                 590         


Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 
        595                 600                 605             


Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 
    610                 615                 620                 


Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 
625                 630                 635                 640 


Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 
                645                 650                 655     


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 
            660                 665                 670         


Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 
        675                 680                 685             


Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 
    690                 695                 700                 


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 
705                 710                 715                 720 


Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 
                725                 730                 735     


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            740                 745                 750         


Gly Arg Lys Arg Lys 
        755         


<210>  7
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  7
gatcgctagc gccgccacca tggcgggtct gacggcggcg gccccgcgg                   49


<210>  8
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  8
gctaagatct tcattttctc ttccggccac aagctttccc cagg                        44


<210>  9
<211>  1984
<212>  DNA
<213>  Homo sapiens

<400>  9
ggatccagag atttagattt tttataagct ttcctgccac cgaaacgggt gtttgggacc       60

tcacgaggcc ctgttcattc ttcgtcgctg cgctccccac tctgtactgg atgcatttac      120

tgacgttgtt gtctccgtcc ccagagtatg aacccccaag gtgactcatg cagctgtggg      180

tgcccggcat acagcatggt gactggaatg gatgagcacc caataaacat ttgttgcagg      240

aatgcaggag gacgggcagg ccagcaagca ggctgcctgg tttttcccac atgggctttt      300

ctgggaaaga agagcttcta tttttggaaa gggctgctat gattgagaaa agttcatggc      360

agcaaaaaaa ggacagacgt cgggagggaa acactcctag ttctcccaga caacacattt      420

tttaaaaaga ctccttcatc tctttaataa taacggtaac gacaatgaca atgatgatta      480

cttatgagtg cggctagtgc cagccactgt gttgtcactg ggcgagtaat gatctcattg      540

gatcttcacg gtgggcgtgc ggggctccag ggacagcctg cgttcctggg ctggctgggt      600

gcagctctct tttcaggaga gaaagctctc ttggaggagc tggaaaggtg cccgactcca      660

gccatgctgg cgctactgtg ttcctgcctg ctcctggcag ccggtgcctc ggacgcctgg      720

acgggcgagg actcggcgga gcccaactct gactcggcgg agtggatccg agacatgtac      780

gccaaggtca cggagatctg gcaggaggtc atgcagcggc gggacgacga cggcacgctc      840

cacgccgcct gccaggtgca gccgtcggcc acgctggacg ccgcgcagcc ccgggtgacc      900

ggcgtcgtcc tcttccggca gcttgcgccc cgcgccaagc tcgacgcctt cttcgccctg      960

gagggcttcc cgaccgagcc gaacagctcc agccgcgcca tccacgtgca ccagttcggg     1020

gacctgagcc agggctgcga gtccaccggg ccccactaca acccgctggc cgtgccgcac     1080

ccgcagcacc cgggcgactt cggcaacttc gcggtccgcg acggcagcct ctggaggtac     1140

cgcgccggcc tggccgcctc gctcgcgggc ccgcactcca tcgtgggccg ggccgtggtc     1200

gtccacgctg gcgaggacga cctgggccgc ggcggcaacc aggccagcgt ggagaacggg     1260

aacgcgggcc ggcggctggc ctgctgcgtg gtgggcgtgt gcgggcccgg gctctgggag     1320

cgccaggcgc gggagcactc agagcgcaag aagcggcggc gcgagagcga gtgcaaggcc     1380

gcctgagcgc ggcccccacc cggcggcggc cagggacccc cgaggccccc ctctgccttt     1440

gagcttctcc tctgctccaa cagacacctt ccactctgag gtctcacctt cgcctctgct     1500

gaagtctccc cgcagccctc tccacccaga ggtctcccta taccgagacc caccatcctt     1560

ccatcctgag gaccgcccca accctcggag ccccccactc agtaggtctg aaggcctcca     1620

tttgtaccga aacaccccgc tcacgctgac agcctcctag gctccctgag gtacctttcc     1680

acccagaccc tccttcccca ccccataagc cctgagactc ccgcctttga cctgacgatc     1740

ttcccccttc ccgccttcag gttcctccta ggcgctcaga ggccgctctg gggggttgcc     1800

tcgagtcccc ccacccctcc ccacccacca ccgctcccgc ggcaagccag cccgtgcaac     1860

ggaagccagg ccaactgccc cgcgtcttca gctgtttcgc atccaccgcc accccactga     1920

gagctgctcc tttgggggaa tgtttggcaa cctttgtgtt acagattaaa aattcagcaa     1980

ttca                                                                  1984


<210>  10
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 
1               5                   10                  15      


Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala 
            20                  25                  30          


Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu 
        35                  40                  45              


Val Met Gln Arg Arg Asp Asp Asp Gly Thr Leu His Ala Ala Cys Gln 
    50                  55                  60                  


Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly 
65                  70                  75                  80  


Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe 
                85                  90                  95      


Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala 
            100                 105                 110         


Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr 
        115                 120                 125             


Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly 
    130                 135                 140                 


Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg 
145                 150                 155                 160 


Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg 
                165                 170                 175     


Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn 
            180                 185                 190         


Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys 
        195                 200                 205             


Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu 
    210                 215                 220                 


His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala 
225                 230                 235                 240 


<210>  11
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  11
gatcgctagc gccgccacca tgctggcgct actgtgttcc tgcctgctcc tggcag           56


<210>  12
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  12
cgataagctt tcaggcggcc ttgcactcgc tctcgcgccg ccgctt                      46


<210>  13
<211>  931
<212>  DNA
<213>  Homo sapiens

<400>  13
tttcgtcggc ccgccccttg gcttctgcac tgatggtggg tggatgagta atgcatccag       60

gaagcctgga ggcctgtggt ttccgcaccc gctgccaccc ccgcccctag cgtggacatt      120

tatcctctag cgctcaggcc ctgccgccat cgccgcagat ccagcgccca gagagacacc      180

agagaaccca ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg      240

ctgatagccc ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc      300

aattccgacc tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc      360

ttataccagc gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg      420

gatgccgctg acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc      480

cacaggtccc acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc      540

ttgcacatca ctacctgcag ttttgtggct ccctggaaca gcctgagctt agctcagcgc      600

cggggcttca ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta      660

tccatcccct gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa      720

ggctctgaaa agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg      780

tgcacctggc agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaagctgaa      840

gcctgcacag tgtccaccct gttcccactc ccatctttct tccggacaat gaaataaaga      900

gttaccaccc agcagaaaaa aaaaaaaaaa a                                     931


<210>  14
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  15
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  15
gatcgctagc gccgccacca tggccccctt tgagcccctg gcttctggca tcctg            55


<210>  16
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  16
cgataagctt tcaggctatc tgggaccgca gggactgcca ggtgca                      46


<210>  17
<211>  4101
<212>  DNA
<213>  Homo sapiens

<400>  17
atgctcagct ttgtggatac gcggactttg ttgctgcttg cagtaacctt atgcctagca       60

acatgccaat ctttacaaga ggaaactgta agaaagggcc cagccggaga tagaggacca      120

cgtggagaaa ggggtccacc aggcccccca ggcagagatg gtgaagatgg tcccacaggc      180

cctcctggtc cacctggtcc tcctggcccc cctggtctcg gtgggaactt tgctgctcag      240

tatgatggaa aaggagttgg acttggccct ggaccaatgg gcttaatggg acctagaggc      300

ccacctggtg cagctggagc cccaggccct caaggtttcc aaggacctgc tggtgagcct      360

ggtgaacctg gtcaaactgg tcctgcaggt gctcgtggtc cagctggccc tcctggcaag      420

gctggtgaag atggtcaccc tggaaaaccc ggacgacctg gtgagagagg agttgttgga      480

ccacagggtg ctcgtggttt ccctggaact cctggacttc ctggcttcaa aggcattagg      540

ggacacaatg gtctggatgg attgaaggga cagcccggtg ctcctggtgt gaagggtgaa      600

cctggtgccc ctggtgaaaa tggaactcca ggtcaaacag gagcccgtgg gcttcctggt      660

gagagaggac gtgttggtgc ccctggccca gctggtgccc gtggcagtga tggaagtgtg      720

ggtcccgtgg gtcctgctgg tcccattggg tctgctggcc ctccaggctt cccaggtgcc      780

cctggcccca agggtgaaat tggagctgtt ggtaacgctg gtcctgctgg tcccgccggt      840

ccccgtggtg aagtgggtct tccaggcctc tccggccccg ttggacctcc tggtaatcct      900

ggagcaaacg gccttactgg tgccaagggt gctgctggcc ttcccggcgt tgctggggct      960

cccggcctcc ctggaccccg cggtattcct ggccctgttg gtgctgccgg tgctactggt     1020

gccagaggac ttgttggtga gcctggtcca gctggctcca aaggagagag cggtaacaag     1080

ggtgagcccg gctctgctgg gccccaaggt cctcctggtc ccagtggtga agaaggaaag     1140

agaggcccta atggggaagc tggatctgcc ggccctccag gacctcctgg gctgagaggt     1200

agtcctggtt ctcgtggtct tcctggagct gatggcagag ctggcgtcat gggccctcct     1260

ggtagtcgtg gtgcaagtgg ccctgctgga gtccgaggac ctaatggaga tgctggtcgc     1320

cctggggagc ctggtctcat gggacccaga ggtcttcctg gttcccctgg aaatatcggc     1380

cccgctggaa aagaaggtcc tgtcggcctc cctggcatcg acggcaggcc tggcccaatt     1440

ggcccagctg gagcaagagg agagcctggc aacattggat tccctggacc caaaggcccc     1500

actggtgatc ctggcaaaaa cggtgataaa ggtcatgctg gtcttgctgg tgctcggggt     1560

gctccaggtc ctgatggaaa caatggtgct cagggacctc ctggaccaca gggtgttcaa     1620

ggtggaaaag gtgaacaggg tccccctggt cctccaggct tccagggtct gcctggcccc     1680

tcaggtcccg ctggtgaagt tggcaaacca ggagaaaggg gtctccatgg tgagtttggt     1740

ctccctggtc ctgctggtcc aagaggggaa cgcggtcccc caggtgagag tggtgctgcc     1800

ggtcctactg gtcctattgg aagccgaggt ccttctggac ccccagggcc tgatggaaac     1860

aagggtgaac ctggtgtggt tggtgctgtg ggcactgctg gtccatctgg tcctagtgga     1920

ctcccaggag agaggggtgc tgctggcata cctggaggca agggagaaaa gggtgaacct     1980

ggtctcagag gtgaaattgg taaccctggc agagatggtg ctcgtggtgc tcctggtgct     2040

gtaggtgccc ctggtcctgc tggagccaca ggtgaccggg gcgaagctgg ggctgctggt     2100

cctgctggtc ctgctggtcc tcggggaagc cctggtgaac gtggtgaggt cggtcctgct     2160

ggccccaatg gatttgctgg tcctgctggt gctgctggtc aacctggtgc taaaggagaa     2220

agaggagcca aagggcctaa gggtgaaaac ggtgttgttg gtcccacagg ccccgttgga     2280

gctgctggcc cagctggtcc aaatggtccc cccggtcctg ctggaagtcg tggtgatgga     2340

ggcccccctg gtatgactgg tttccctggt gctgctggac ggactggtcc cccaggaccc     2400

tctggtattt ctggccctcc tggtccccct ggtcctgctg ggaaagaagg gcttcgtggt     2460

cctcgtggtg accaaggtcc agttggccga actggagaag taggtgcagt tggtccccct     2520

ggcttcgctg gtgagaaggg tccctctgga gaggctggta ctgctggacc tcctggcact     2580

ccaggtcctc agggtcttct tggtgctcct ggtattctgg gtctccctgg ctcgagaggt     2640

gaacgtggtc taccaggtgt tgctggtgct gtgggtgaac ctggtcctct tggcattgcc     2700

ggccctcctg gggcccgtgg tcctcctggt gctgtgggta gtcctggagt caacggtgct     2760

cctggtgaag ctggtcgtga tggcaaccct gggaacgatg gtcccccagg tcgcgatggt     2820

caacccggac acaagggaga gcgcggttac cctggcaata ttggtcccgt tggtgctgca     2880

ggtgcacctg gtcctcatgg ccccgtgggt cctgctggca aacatggaaa ccgtggtgaa     2940

actggtcctt ctggtcctgt tggtcctgct ggtgctgttg gcccaagagg tcctagtggc     3000

ccacaaggca ttcgtggcga taagggagag cccggtgaaa aggggcccag aggtcttcct     3060

ggcttaaagg gacacaatgg attgcaaggt ctgcctggta tcgctggtca ccatggtgat     3120

caaggtgctc ctggctccgt gggtcctgct ggtcctaggg gccctgctgg tccttctggc     3180

cctgctggaa aagatggtcg cactggacat cctggtacag ttggacctgc tggcattcga     3240

ggccctcagg gtcaccaagg ccctgctggc ccccctggtc cccctggccc tcctggacct     3300

ccaggtgtaa gcggtggtgg ttatgacttt ggttacgatg gagacttcta cagggctgac     3360

cagcctcgct cagcaccttc tctcagaccc aaggactatg aagttgatgc tactctgaag     3420

tctctcaaca accagattga gacccttctt actcctgaag gctctagaaa gaacccagct     3480

cgcacatgcc gtgacttgag actcagccac ccagagtgga gcagtggtta ctactggatt     3540

gaccctaacc aaggatgcac tatggatgct atcaaagtat actgtgattt ctctactggc     3600

gaaacctgta tccgggccca acctgaaaac atcccagcca agaactggta taggagctcc     3660

aaggacaaga aacacgtctg gctaggagaa actatcaatg ctggcagcca gtttgaatat     3720

aatgtagaag gagtgacttc caaggaaatg gctacccaac ttgccttcat gcgcctgctg     3780

gccaactatg cctctcagaa catcacctac cactgcaaga acagcattgc atacatggat     3840

gaggagactg gcaacctgaa aaaggctgtc attctacagg gctctaatga tgttgaactt     3900

gttgctgagg gcaacagcag gttcacttac actgttcttg tagatggctg ctctaaaaag     3960

acaaatgaat ggggaaagac aatcattgaa tacaaaacaa ataagccatc acgcctgccc     4020

ttccttgata ttgcaccttt ggacatcggt ggtgctgacc aggaattctt tgtggacatt     4080

ggcccagtct gtttcaaata a                                               4101


<210>  18
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  19
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  19
gatcgctagc gccgccacca tgctcagctt tgtggatacg cggactttgt tgctgctt         58


<210>  20
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence = synthetic construct

<400>  20
cgataagctt ttatttgaaa cagactgggc caatgtccac aaagaattcc t                51


<210>  21
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence = synthetic construct

<400>  21
gatcgctagc gccgccacca tgcacaaatg gatactgaca tggatc                      46


<210>  22
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence = artificial construct

<400>  22
cgataagctt ttaagttatt gccataggaa gaaagtgggc tgttttttgt                  50


<210>  23
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  23

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  24
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  24
acgcgctcac acacagagag aaaatccttc tgcctgttga tttatggaaa caattatgat       60

tctgctggag aacttttcag ctgagaaata gtttgtagct acagtagaaa ggctcaagtt      120

gcaccaggca gacaacagac atggaattct tatatatcca gctgttagca acaaaacaaa      180

agtcaaatag caaacagcgt cacagcaact gaacttacta cgaactgttt ttatgaggat      240

ttatcaacag agttatttaa ggaggaatcc tgtgttgtta tcaggaacta aaaggataag      300

gctaacaatt tggaaagagc aagtactctt tcttaaatca atctacaatt cacagatagg      360

aagaggtcaa tgacctagga gtaacaatca actcaagatt cattttcatt atgttattca      420

tgaacacccg gagcactaca ctataatgca caaatggata ctgacatgga tcctgccaac      480

tttgctctac agatcatgct ttcacattat ctgtctagtg ggtactatat ctttagcttg      540

caatgacatg actccagagc aaatggctac aaatgtgaac tgttccagcc ctgagcgaca      600

cacaagaagt tatgattaca tggaaggagg ggatataaga gtgagaagac tcttctgtcg      660

aacacagtgg tacctgagga tcgataaaag aggcaaagta aaagggaccc aagagatgaa      720

gaataattac aatatcatgg aaatcaggac agtggcagtt ggaattgtgg caatcaaagg      780

ggtggaaagt gaattctatc ttgcaatgaa caaggaagga aaactctatg caaagaaaga      840

atgcaatgaa gattgtaact tcaaagaact aattctggaa aaccattaca acacatatgc      900

atcagctaaa tggacacaca acggagggga aatgtttgtt gccttaaatc aaaaggggat      960

tcctgtaaga ggaaaaaaaa cgaagaaaga acaaaaaaca gcccactttc ttcctatggc     1020

aataacttaa ttgcatatgg tatataaaga acccagttcc agcagggaga tttctttaag     1080

tggactgttt tctttcttct caaaattttc tttcctttta ttttttagta atcaagaaag     1140

gctggaaaaa ctactgaaaa actgatcaag ctggacttgt gcatttatgt ttgttttaag     1200

acactgcatt aaagaaagat ttgaaaagta tacacaaaaa tcagatttag taactaaagg     1260

ttgtaaaaaa ttgtaaaact ggttgtacaa tcatgatgtt agtaacagta atttttttct     1320

taaattaatt tacccttaag agtatgttag atttgattat ctgataatga ttatttaaat     1380

attcctatct gcttataaaa tggctgctat aataataata atacagatgt tgttatataa     1440


