                         SEQUENCE LISTING

<110>  Codexis, Inc.
       McDaniel, Robert
       Behrouzian, Behnaz
       Clark, Louis
       Hattendorf, Douglas
       Valle, Fernando
 
<120>  PRODUCTION OF FATTY ALCOHOLS WITH FATTY ALCOHOL FORMING ACYL-COA 
       REDUCTASES (FAR)

<130>  CX3-017WO1

<150>  US 61/221,934
<151>  2009-06-30

<150>  US 61/315,380
<151>  2010-03-18

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1539
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1539)

<400>  1
atg gct act caa caa caa cag aac ggt gca tct gca tcc ggc gtc ttg         48
Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu           
1               5                   10                  15                

gaa caa ctt cgt gga aag cac gtt ctt atc aca ggt act acc gga ttt         96
Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe           
            20                  25                  30                    

ttg ggc aaa gtg gtt ctg gaa aag ttg att cgt act gtt ccg gat att        144
Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile           
        35                  40                  45                        

gga ggt att cat ctg ctg att cgt ggc aat aaa cgt cat cca gcc gct        192
Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala           
    50                  55                  60                            

cgt gaa cgt ttc ctg aac gaa att gcg tcc tcc tcc gtc ttc gaa cgt        240
Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg           
65                  70                  75                  80            

ttg cgt cac gat gat aat gaa gcc ttc gag acc ttc ttg gaa gaa cgt        288
Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg           
                85                  90                  95                

gtt cac tgt att acc ggt gag gtt act gaa tcc cgt ttt ggt ttg aca        336
Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr           
            100                 105                 110                   

cct gaa cgt ttt cgt gct ttg gcc ggt cag gtt gac gct ttt att aac        384
Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn           
        115                 120                 125                       

agc gct gca agc gtg aac ttt cgt gag gaa ttg gat aaa gcc ctg aaa        432
Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu Lys           
    130                 135                 140                           

atc aac acc ttg tgt ctt gaa aat gtt gct gct ctt gca gaa ttg aac        480
Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn           
145                 150                 155                 160           

tcc gct atg gcg gtc att cag gtt tcc act tgt tac gtt aac ggt aaa        528
Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys           
                165                 170                 175               

aac tcc ggt caa att acc gaa tcc gtc att aaa cct gct ggc gaa tcc        576
Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Pro Ala Gly Glu Ser           
            180                 185                 190                   

att ccc cgt tcc act gac ggt tac tac gag atc gaa gaa ttg gtc cat        624
Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His           
        195                 200                 205                       

ctg ttg caa gac aag att tcc gat gtt aaa gct cgt tac tcc ggc aaa        672
Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys           
    210                 215                 220                           

gtt ctg gag aaa aaa ttg gtt gat ttg ggt att cgt gag gcc aat aat        720
Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn           
225                 230                 235                 240           

tac gga tgg tcc gac acc tac aca ttc acc aaa tgg ttg ggt gaa caa        768
Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln           
                245                 250                 255               

ctg ctg atg aag gcc ttg tct ggt cgt tct ttg act att gtg cgt ccc        816
Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro           
            260                 265                 270                   

tct att att gag tcc gct ttg gaa gaa cct tcc cct ggt tgg atc gaa        864
Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu           
        275                 280                 285                       

ggc gtt aaa gtt gcc gat gcc att atc ttg gct tat gcc cgt gaa aaa        912
Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys           
    290                 295                 300                           

gtt agc ctg ttc cct gga aaa cgt tcc ggc att att gat gtt att cct        960
Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro           
305                 310                 315                 320           

gtc gat ttg gtt gcg aac tcc atc atc ttg tct ctg gct gag gcg ttg       1008
Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu           
                325                 330                 335               

tct ggt tct ggt caa cgt cgt att tat caa tgt tgc agc ggt ggt tct       1056
Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser           
            340                 345                 350                   

aat cca atc tcc ctg ggt aag ttc att gat tat ttg atg gcc gag gct       1104
Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala           
        355                 360                 365                       

aag acc aac tat gct gcc tac gat caa ctg ttt tat cgt cgt cct act       1152
Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr           
    370                 375                 380                           

aaa cct ttc gtc gcc gtg aac cgt aaa ttg ttt gac gtt gtt gtt ggt       1200
Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly           
385                 390                 395                 400           

ggt atg cgt gtt cct ctt tct att gcc ggt aaa gct atg cgt ttg gct       1248
Gly Met Arg Val Pro Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala           
                405                 410                 415               

ggt caa aat cgt gag ttg aaa gtg ctt aag aac ctt gat acg acc cgt       1296
Gly Gln Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg           
            420                 425                 430                   

tcc ctt gca acc att ttt ggc ttc tat act gct ccc gac tat atc ttc       1344
Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe           
        435                 440                 445                       

cgt aac gat agc ttg atg gcc ctg gct tct cgt atg ggt gaa ttg gat       1392
Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp           
    450                 455                 460                           

cgt gtt ctt ttc cca gtt gat gct cgt caa att gat tgg cag ttg tac       1440
Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr           
465                 470                 475                 480           

ttg tgt aaa att cat ttg ggt ggt ctg aac cgt tac gct ttg aag gaa       1488
Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu           
                485                 490                 495               

cgt aaa ctg tat tct ttg cgt gct gct gat act cgt aaa aaa gct gcc       1536
Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Ala Ala           
            500                 505                 510                   

taa                                                                   1539


<210>  2
<211>  512
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Pro Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Pro Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Gln Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Ala Ala 
            500                 505                 510         


<210>  3
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1536)

<400>  3
atg gcc acc cag cag cag cag aac ggt gca tcc gct tcg ggc gtt ctg         48
Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu           
1               5                   10                  15                

gag cag ctt aga ggc aag cat gtc ttg att acc ggt act aca gga ttt         96
Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe           
            20                  25                  30                    

ctg gga aag gtg gtt ctg gag aag ctg atc cga acc gtg cct gac atc        144
Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile           
        35                  40                  45                        

ggt ggt att cat ctg ctg att aga ggc aac aag aga cat cct gct gcc        192
Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala           
    50                  55                  60                            

aga gaa aga ttc ttg aac gaa atc gcc tct tcc tct gtg ttc gag cgg        240
Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg           
65                  70                  75                  80            

ctt aga cat gac gac aac gaa gcc ttt gag act ttc ctg gag gag cgt        288
Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg           
                85                  90                  95                

gtg cac tgc atc acc gga gaa gtg acc gag tcg aga ttt ggc ctt act        336
Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr           
            100                 105                 110                   

cct gag cgg ttc cga gcc ctt gct ggc caa gtg gat gcc ttc atc aat        384
Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn           
        115                 120                 125                       

tcc gcc gcc tct gtt aac ttc aga gag gag ctg gac aag gca ctc aag        432
Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu Lys           
    130                 135                 140                           

atc aac acc ctg tgt ctg gag aac gtg gct gct ctg gcc gaa ctt aac        480
Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn           
145                 150                 155                 160           

tcc gct atg gca gtg atc caa gtt tcc acc tgt tac gtg aac ggc aag        528
Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys           
                165                 170                 175               

aac tct gga cag atc acc gag tcc gtt atc aag ccc gct ggc gaa tcc        576
Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Pro Ala Gly Glu Ser           
            180                 185                 190                   

atc ccc aga tcc aca gat ggc tac tac gag atc gag gag ctg gtc cac        624
Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His           
        195                 200                 205                       

ctt ctg caa gac aag atc tcc gac gtg aag gct cga tac tct ggc aag        672
Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys           
    210                 215                 220                           

gtg ttg gag aag aag ctg gtg gac ctg ggc atc cga gag gcg aac aac        720
Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn           
225                 230                 235                 240           

tac ggc tgg tct gac acc tac acc ttc acc aaa tgg ctc gga gag cag        768
Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln           
                245                 250                 255               

ctt ctg atg aaa gct ctg tcc gga aga tcc ctg act atc gtg cgg cct        816
Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro           
            260                 265                 270                   

tcc atc atc gag tcg gct ctt gaa gag cct tct cca ggt tgg atc gag        864
Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu           
        275                 280                 285                       

ggc gtg aag gtt gct gac gcc atc atc ctt gcg tac gcc aga gag aag        912
Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys           
    290                 295                 300                           

gtt tcg ttg ttc ccc ggc aag cga tct ggc atc atc gac gtt atc ccc        960
Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro           
305                 310                 315                 320           

gtg gat ctg gtg gcc aac tct atc att ctc tct ctt gct gaa gcc ctt       1008
Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu           
                325                 330                 335               

tct gga tct ggc cag cgt aga atc tac caa tgt tgt tct ggc ggt tct       1056
Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser           
            340                 345                 350                   

aac ccg att tct ctg ggc aag ttc atc gac tac ctt atg gcc gaa gcc       1104
Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala           
        355                 360                 365                       

aag acc aac tat gct gcc tac gac cag ctc ttc tac cga cga ccc acc       1152
Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr           
    370                 375                 380                           

aag ccc ttc gtc gct gtg aac cga aag ctg ttc gat gtt gtc gtg gga       1200
Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly           
385                 390                 395                 400           

gga atg cga gtg cct ctt tcc att gct ggc aag gcc atg aga ttg gcg       1248
Gly Met Arg Val Pro Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala           
                405                 410                 415               

ggt cag aat cga gaa ttg aag gtt ctc aag aac ctt gac act act cga       1296
Gly Gln Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg           
            420                 425                 430                   

tcg ctc gct act atc ttt gga ttc tac act gct cct gac tac atc ttc       1344
Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe           
        435                 440                 445                       

cgg aat gac tct ctg atg gct ctt gct tcc cga atg gga gaa ctc gat       1392
Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp           
    450                 455                 460                           

cgt gtg ctg ttc cct gtt gac gct cga cag atc gac tgg cag ctc tac       1440
Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr           
465                 470                 475                 480           

ttg tgt aag atc cac ctg ggc ggc ctg aac cga tat gct ctg aaa gaa       1488
Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu           
                485                 490                 495               

cga aag ctg tac agc ctt aga gcc gct gat acc cga aag aag gct gct       1536
Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Ala Ala           
            500                 505                 510                   


<210>  4
<211>  512
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Pro Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Pro Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Gln Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Ala Ala 
            500                 505                 510         


<210>  5
<211>  1545
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1545)

<400>  5
atg tct cag tac tcc gcg ttc tcc gtt tct caa tct ttg aag ggc aaa         48
Met Ser Gln Tyr Ser Ala Phe Ser Val Ser Gln Ser Leu Lys Gly Lys           
1               5                   10                  15                

cat atc ttc ttg aca ggt gtt acg ggt ttc ttg ggc aag gcg att ctg         96
His Ile Phe Leu Thr Gly Val Thr Gly Phe Leu Gly Lys Ala Ile Leu           
            20                  25                  30                    

gag aaa ctg ttg tac tcc gtt cca caa ttg gct cag att cat atc ctg        144
Glu Lys Leu Leu Tyr Ser Val Pro Gln Leu Ala Gln Ile His Ile Leu           
        35                  40                  45                        

gtc cgt ggt ggt aaa gtt agc gct aag aag cgt ttc caa cat gac atc        192
Val Arg Gly Gly Lys Val Ser Ala Lys Lys Arg Phe Gln His Asp Ile           
    50                  55                  60                            

ttg ggt tct tcc atc ttt gag cgt ctt aag gaa caa cat ggc gaa cat        240
Leu Gly Ser Ser Ile Phe Glu Arg Leu Lys Glu Gln His Gly Glu His           
65                  70                  75                  80            

ttc gaa gaa tgg gtt caa agc aag atc aac ctt gtc gag ggc gaa ctt        288
Phe Glu Glu Trp Val Gln Ser Lys Ile Asn Leu Val Glu Gly Glu Leu           
                85                  90                  95                

act caa cct atg ttc gat ttg cct tct gct gag ttc gct ggc ttg gct        336
Thr Gln Pro Met Phe Asp Leu Pro Ser Ala Glu Phe Ala Gly Leu Ala           
            100                 105                 110                   

aac caa ttg gat ctg atc atc aat agc gct gct tct gtc aac ttt cgt        384
Asn Gln Leu Asp Leu Ile Ile Asn Ser Ala Ala Ser Val Asn Phe Arg           
        115                 120                 125                       

gag aac ttg gag aag gct ctg aac atc aat acc ctg tgt ctg aac aac        432
Glu Asn Leu Glu Lys Ala Leu Asn Ile Asn Thr Leu Cys Leu Asn Asn           
    130                 135                 140                           

atc att gcg ctg gct cag tac aac gtc gct gct caa act cct gtt atg        480
Ile Ile Ala Leu Ala Gln Tyr Asn Val Ala Ala Gln Thr Pro Val Met           
145                 150                 155                 160           

caa atc tcc acc tgc tat gtc aac ggc ttc aac aaa ggc caa atc aac        528
Gln Ile Ser Thr Cys Tyr Val Asn Gly Phe Asn Lys Gly Gln Ile Asn           
                165                 170                 175               

gag gaa gtt gtt ggt cct gct tct ggt ttg att cct cag ttg tcc caa        576
Glu Glu Val Val Gly Pro Ala Ser Gly Leu Ile Pro Gln Leu Ser Gln           
            180                 185                 190                   

gac tgc tac gac att gat tcc gtc ttc aag cgt gtt cat tcc cag att        624
Asp Cys Tyr Asp Ile Asp Ser Val Phe Lys Arg Val His Ser Gln Ile           
        195                 200                 205                       

gaa caa gtc aag aaa cgt aag acc gac att gaa cag caa gaa caa gcc        672
Glu Gln Val Lys Lys Arg Lys Thr Asp Ile Glu Gln Gln Glu Gln Ala           
    210                 215                 220                           

ttg atc aaa ctg ggt atc aag acc tct caa cat ttc ggc tgg aat gat        720
Leu Ile Lys Leu Gly Ile Lys Thr Ser Gln His Phe Gly Trp Asn Asp           
225                 230                 235                 240           

acc tac acc ttc acc aag tgg ctg ggt gaa caa ttg ttg att cag aag        768
Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln Leu Leu Ile Gln Lys           
                245                 250                 255               

ttg ggc aag caa tct ttg aca att ctt cgt ccg tcc atc atc gaa tct        816
Leu Gly Lys Gln Ser Leu Thr Ile Leu Arg Pro Ser Ile Ile Glu Ser           
            260                 265                 270                   

gct gtt cgt gaa cct gct cct ggc tgg gtt gaa ggc gtg aaa gtt gcg        864
Ala Val Arg Glu Pro Ala Pro Gly Trp Val Glu Gly Val Lys Val Ala           
        275                 280                 285                       

gat gcc ttg atc tat gct tac gct aaa ggt cgt gtt agc atc ttt ccc        912
Asp Ala Leu Ile Tyr Ala Tyr Ala Lys Gly Arg Val Ser Ile Phe Pro           
    290                 295                 300                           

ggt cgt gat gaa ggt atc ttg gat gtc atc cct gtt gat ttg gtt gct        960
Gly Arg Asp Glu Gly Ile Leu Asp Val Ile Pro Val Asp Leu Val Ala           
305                 310                 315                 320           

aat gcc gcc gca ttg tcc gct gct cag ctt atg gaa tct aac cag caa       1008
Asn Ala Ala Ala Leu Ser Ala Ala Gln Leu Met Glu Ser Asn Gln Gln           
                325                 330                 335               

act ggc tat cgt atc tat caa tgc tgt tct ggt tcc cgt aat ccg atc       1056
Thr Gly Tyr Arg Ile Tyr Gln Cys Cys Ser Gly Ser Arg Asn Pro Ile           
            340                 345                 350                   

aag ctg aaa gag ttc att cgt cac att cag aat gtt gct caa gcc cgt       1104
Lys Leu Lys Glu Phe Ile Arg His Ile Gln Asn Val Ala Gln Ala Arg           
        355                 360                 365                       

tac caa gaa tgg cca aag ttg ttt gct gac aaa cct cag gaa gcc ttc       1152
Tyr Gln Glu Trp Pro Lys Leu Phe Ala Asp Lys Pro Gln Glu Ala Phe           
    370                 375                 380                           

aag acc gtg tct cct aaa cgt ttc aag ctg tac atg tct ggt ttc act       1200
Lys Thr Val Ser Pro Lys Arg Phe Lys Leu Tyr Met Ser Gly Phe Thr           
385                 390                 395                 400           

gct atc aca tgg gct aag acc atc att ggt cgt gtc ttt gga tct aat       1248
Ala Ile Thr Trp Ala Lys Thr Ile Ile Gly Arg Val Phe Gly Ser Asn           
                405                 410                 415               

gct gcc tcc caa cac atg ttg aag gct aag acc aca gca tct ttg gcg       1296
Ala Ala Ser Gln His Met Leu Lys Ala Lys Thr Thr Ala Ser Leu Ala           
            420                 425                 430                   

aac atc ttt ggt ttc tac act gct cct aac tac cgt ttc tcc tct cag       1344
Asn Ile Phe Gly Phe Tyr Thr Ala Pro Asn Tyr Arg Phe Ser Ser Gln           
        435                 440                 445                       

aag ttg gaa cag ttg gtc aaa cag ttc gat act acc gaa caa cgt ctt       1392
Lys Leu Glu Gln Leu Val Lys Gln Phe Asp Thr Thr Glu Gln Arg Leu           
    450                 455                 460                           

tac gac att cgt gct gac cat ttc gat tgg aag tac tac ttg cag gaa       1440
Tyr Asp Ile Arg Ala Asp His Phe Asp Trp Lys Tyr Tyr Leu Gln Glu           
465                 470                 475                 480           

gtt cac atg gat ggt ctt cac aag tat gcg ttg gcc gat cgt caa gaa       1488
Val His Met Asp Gly Leu His Lys Tyr Ala Leu Ala Asp Arg Gln Glu           
                485                 490                 495               

ttg aag ccc aaa cat gtg aag aag cgt aaa cgt gaa acg att cgt caa       1536
Leu Lys Pro Lys His Val Lys Lys Arg Lys Arg Glu Thr Ile Arg Gln           
            500                 505                 510                   

gct gct taa                                                           1545
Ala Ala                                                                   
                                                                          


<210>  6
<211>  514
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Gln Tyr Ser Ala Phe Ser Val Ser Gln Ser Leu Lys Gly Lys 
1               5                   10                  15      


His Ile Phe Leu Thr Gly Val Thr Gly Phe Leu Gly Lys Ala Ile Leu 
            20                  25                  30          


Glu Lys Leu Leu Tyr Ser Val Pro Gln Leu Ala Gln Ile His Ile Leu 
        35                  40                  45              


Val Arg Gly Gly Lys Val Ser Ala Lys Lys Arg Phe Gln His Asp Ile 
    50                  55                  60                  


Leu Gly Ser Ser Ile Phe Glu Arg Leu Lys Glu Gln His Gly Glu His 
65                  70                  75                  80  


Phe Glu Glu Trp Val Gln Ser Lys Ile Asn Leu Val Glu Gly Glu Leu 
                85                  90                  95      


Thr Gln Pro Met Phe Asp Leu Pro Ser Ala Glu Phe Ala Gly Leu Ala 
            100                 105                 110         


Asn Gln Leu Asp Leu Ile Ile Asn Ser Ala Ala Ser Val Asn Phe Arg 
        115                 120                 125             


Glu Asn Leu Glu Lys Ala Leu Asn Ile Asn Thr Leu Cys Leu Asn Asn 
    130                 135                 140                 


Ile Ile Ala Leu Ala Gln Tyr Asn Val Ala Ala Gln Thr Pro Val Met 
145                 150                 155                 160 


Gln Ile Ser Thr Cys Tyr Val Asn Gly Phe Asn Lys Gly Gln Ile Asn 
                165                 170                 175     


Glu Glu Val Val Gly Pro Ala Ser Gly Leu Ile Pro Gln Leu Ser Gln 
            180                 185                 190         


Asp Cys Tyr Asp Ile Asp Ser Val Phe Lys Arg Val His Ser Gln Ile 
        195                 200                 205             


Glu Gln Val Lys Lys Arg Lys Thr Asp Ile Glu Gln Gln Glu Gln Ala 
    210                 215                 220                 


Leu Ile Lys Leu Gly Ile Lys Thr Ser Gln His Phe Gly Trp Asn Asp 
225                 230                 235                 240 


Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln Leu Leu Ile Gln Lys 
                245                 250                 255     


Leu Gly Lys Gln Ser Leu Thr Ile Leu Arg Pro Ser Ile Ile Glu Ser 
            260                 265                 270         


Ala Val Arg Glu Pro Ala Pro Gly Trp Val Glu Gly Val Lys Val Ala 
        275                 280                 285             


Asp Ala Leu Ile Tyr Ala Tyr Ala Lys Gly Arg Val Ser Ile Phe Pro 
    290                 295                 300                 


Gly Arg Asp Glu Gly Ile Leu Asp Val Ile Pro Val Asp Leu Val Ala 
305                 310                 315                 320 


Asn Ala Ala Ala Leu Ser Ala Ala Gln Leu Met Glu Ser Asn Gln Gln 
                325                 330                 335     


Thr Gly Tyr Arg Ile Tyr Gln Cys Cys Ser Gly Ser Arg Asn Pro Ile 
            340                 345                 350         


Lys Leu Lys Glu Phe Ile Arg His Ile Gln Asn Val Ala Gln Ala Arg 
        355                 360                 365             


Tyr Gln Glu Trp Pro Lys Leu Phe Ala Asp Lys Pro Gln Glu Ala Phe 
    370                 375                 380                 


Lys Thr Val Ser Pro Lys Arg Phe Lys Leu Tyr Met Ser Gly Phe Thr 
385                 390                 395                 400 


Ala Ile Thr Trp Ala Lys Thr Ile Ile Gly Arg Val Phe Gly Ser Asn 
                405                 410                 415     


Ala Ala Ser Gln His Met Leu Lys Ala Lys Thr Thr Ala Ser Leu Ala 
            420                 425                 430         


Asn Ile Phe Gly Phe Tyr Thr Ala Pro Asn Tyr Arg Phe Ser Ser Gln 
        435                 440                 445             


Lys Leu Glu Gln Leu Val Lys Gln Phe Asp Thr Thr Glu Gln Arg Leu 
    450                 455                 460                 


Tyr Asp Ile Arg Ala Asp His Phe Asp Trp Lys Tyr Tyr Leu Gln Glu 
465                 470                 475                 480 


Val His Met Asp Gly Leu His Lys Tyr Ala Leu Ala Asp Arg Gln Glu 
                485                 490                 495     


Leu Lys Pro Lys His Val Lys Lys Arg Lys Arg Glu Thr Ile Arg Gln 
            500                 505                 510         


Ala Ala 
        


<210>  7
<211>  1542
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1542)

<400>  7
atg tcc cag tac tcg gct ttc tct gtt tct caa tct ctg aag ggc aag         48
Met Ser Gln Tyr Ser Ala Phe Ser Val Ser Gln Ser Leu Lys Gly Lys           
1               5                   10                  15                

cac atc ttt ctc act ggt gtc act ggc ttt ctc gga aag gca att ctg         96
His Ile Phe Leu Thr Gly Val Thr Gly Phe Leu Gly Lys Ala Ile Leu           
            20                  25                  30                    

gag aag ctc ttg tac tcg gtt ccc cag ctg gca cag atc cat atc ctt        144
Glu Lys Leu Leu Tyr Ser Val Pro Gln Leu Ala Gln Ile His Ile Leu           
        35                  40                  45                        

gtg aga ggc ggc aaa gtt tct gcc aag aag cgg ttt cag cac gac atc        192
Val Arg Gly Gly Lys Val Ser Ala Lys Lys Arg Phe Gln His Asp Ile           
    50                  55                  60                            

ctg ggc tct agc atc ttc gag aga ctt aag gag caa cac gga gag cac        240
Leu Gly Ser Ser Ile Phe Glu Arg Leu Lys Glu Gln His Gly Glu His           
65                  70                  75                  80            

ttt gag gaa tgg gtt cag tcc aag atc aac ctt gtg gag gga gaa ctg        288
Phe Glu Glu Trp Val Gln Ser Lys Ile Asn Leu Val Glu Gly Glu Leu           
                85                  90                  95                

act caa cca atg ttt gac ctc cct tct gct gag ttc gct gga ctt gct        336
Thr Gln Pro Met Phe Asp Leu Pro Ser Ala Glu Phe Ala Gly Leu Ala           
            100                 105                 110                   

aac cag ctg gac ctg atc atc aac tct gcc gct tcg gtt aac ttt cga        384
Asn Gln Leu Asp Leu Ile Ile Asn Ser Ala Ala Ser Val Asn Phe Arg           
        115                 120                 125                       

gag aac ctg gag aag gct ctg aac atc aac acc ctg tgc ctg aac aac        432
Glu Asn Leu Glu Lys Ala Leu Asn Ile Asn Thr Leu Cys Leu Asn Asn           
    130                 135                 140                           

atc atc gct ctg gct cag tac aat gtc gct gcc cag act cct gtg atg        480
Ile Ile Ala Leu Ala Gln Tyr Asn Val Ala Ala Gln Thr Pro Val Met           
145                 150                 155                 160           

cag att tcc acc tgc tac gtg aac ggc ttc aac aag ggc cag atc aac        528
Gln Ile Ser Thr Cys Tyr Val Asn Gly Phe Asn Lys Gly Gln Ile Asn           
                165                 170                 175               

gaa gaa gtt gtg gga cct gct tct gga ctg atc cct cag ctg tct caa        576
Glu Glu Val Val Gly Pro Ala Ser Gly Leu Ile Pro Gln Leu Ser Gln           
            180                 185                 190                   

gat tgc tac gac atc gac tcc gtc ttc aag aga gtg cat tcc cag att        624
Asp Cys Tyr Asp Ile Asp Ser Val Phe Lys Arg Val His Ser Gln Ile           
        195                 200                 205                       

gag cag gtg aag aag aga aag aca gac att gag cag cag gaa caa gcc        672
Glu Gln Val Lys Lys Arg Lys Thr Asp Ile Glu Gln Gln Glu Gln Ala           
    210                 215                 220                           

ctt atc aag ctc ggt atc aag act tcc cag cac ttt ggc tgg aat gac        720
Leu Ile Lys Leu Gly Ile Lys Thr Ser Gln His Phe Gly Trp Asn Asp           
225                 230                 235                 240           

act tac acc ttc acc aaa tgg ctc ggc gaa cag ctg ttg att cag aag        768
Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln Leu Leu Ile Gln Lys           
                245                 250                 255               

ctc ggc aag caa tct ctc acc att ctt cga cct tcg atc att gag tct        816
Leu Gly Lys Gln Ser Leu Thr Ile Leu Arg Pro Ser Ile Ile Glu Ser           
            260                 265                 270                   

gct gtg aga gag cct gcg ccc gga tgg gtc gaa gga gtg aaa gtc gct        864
Ala Val Arg Glu Pro Ala Pro Gly Trp Val Glu Gly Val Lys Val Ala           
        275                 280                 285                       

gac gcc ctt atc tac gct tat gct aag gga aga gtc tcg atc ttt cct        912
Asp Ala Leu Ile Tyr Ala Tyr Ala Lys Gly Arg Val Ser Ile Phe Pro           
    290                 295                 300                           

gga aga gac gag ggc atc ctt gat gtg att ccc gtt gac ctt gtt gcc        960
Gly Arg Asp Glu Gly Ile Leu Asp Val Ile Pro Val Asp Leu Val Ala           
305                 310                 315                 320           

aat gct gct gct ctt tct gct gca caa ctc atg gag tcc aac caa cag       1008
Asn Ala Ala Ala Leu Ser Ala Ala Gln Leu Met Glu Ser Asn Gln Gln           
                325                 330                 335               

act ggc tac cga atc tac caa tgc tgc tct gga tct cga aac ccc atc       1056
Thr Gly Tyr Arg Ile Tyr Gln Cys Cys Ser Gly Ser Arg Asn Pro Ile           
            340                 345                 350                   

aag ctg aag gag ttc atc cga cac atc cag aac gtg gct cag gcc cga       1104
Lys Leu Lys Glu Phe Ile Arg His Ile Gln Asn Val Ala Gln Ala Arg           
        355                 360                 365                       

tac cag gaa tgg cct aag ctg ttt gcc gat aag cct caa gag gcc ttc       1152
Tyr Gln Glu Trp Pro Lys Leu Phe Ala Asp Lys Pro Gln Glu Ala Phe           
    370                 375                 380                           

aag act gtc tct ccc aag aga ttc aag ctg tac atg tcc ggc ttc act       1200
Lys Thr Val Ser Pro Lys Arg Phe Lys Leu Tyr Met Ser Gly Phe Thr           
385                 390                 395                 400           

gcc atc acc tgg gct aag acc atc att ggc cga gtg ttc ggc tct aac       1248
Ala Ile Thr Trp Ala Lys Thr Ile Ile Gly Arg Val Phe Gly Ser Asn           
                405                 410                 415               

gca gcc tcc cag cac atg ctg aag gca aag acc aca gct tcc ctg gcc       1296
Ala Ala Ser Gln His Met Leu Lys Ala Lys Thr Thr Ala Ser Leu Ala           
            420                 425                 430                   

aac atc ttc ggc ttc tac act gca ccc aac tac cgg ttc tct tcc cag       1344
Asn Ile Phe Gly Phe Tyr Thr Ala Pro Asn Tyr Arg Phe Ser Ser Gln           
        435                 440                 445                       

aag ttg gaa cag ctg gtg aag cag ttc gac act acc gag cag cga ctg       1392
Lys Leu Glu Gln Leu Val Lys Gln Phe Asp Thr Thr Glu Gln Arg Leu           
    450                 455                 460                           

tac gac att cga gct gac cac ttc gac tgg aag tac tac ctg caa gag       1440
Tyr Asp Ile Arg Ala Asp His Phe Asp Trp Lys Tyr Tyr Leu Gln Glu           
465                 470                 475                 480           

gtt cac atg gat ggc ctt cac aag tac gct ttg gcc gat cgt cag gag       1488
Val His Met Asp Gly Leu His Lys Tyr Ala Leu Ala Asp Arg Gln Glu           
                485                 490                 495               

ctg aaa ccc aag cac gtg aag aag aga aag cgg gag act atc cga caa       1536
Leu Lys Pro Lys His Val Lys Lys Arg Lys Arg Glu Thr Ile Arg Gln           
            500                 505                 510                   

gct gcg                                                               1542
Ala Ala                                                                   
                                                                          


<210>  8
<211>  514
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Met Ser Gln Tyr Ser Ala Phe Ser Val Ser Gln Ser Leu Lys Gly Lys 
1               5                   10                  15      


His Ile Phe Leu Thr Gly Val Thr Gly Phe Leu Gly Lys Ala Ile Leu 
            20                  25                  30          


Glu Lys Leu Leu Tyr Ser Val Pro Gln Leu Ala Gln Ile His Ile Leu 
        35                  40                  45              


Val Arg Gly Gly Lys Val Ser Ala Lys Lys Arg Phe Gln His Asp Ile 
    50                  55                  60                  


Leu Gly Ser Ser Ile Phe Glu Arg Leu Lys Glu Gln His Gly Glu His 
65                  70                  75                  80  


Phe Glu Glu Trp Val Gln Ser Lys Ile Asn Leu Val Glu Gly Glu Leu 
                85                  90                  95      


Thr Gln Pro Met Phe Asp Leu Pro Ser Ala Glu Phe Ala Gly Leu Ala 
            100                 105                 110         


Asn Gln Leu Asp Leu Ile Ile Asn Ser Ala Ala Ser Val Asn Phe Arg 
        115                 120                 125             


Glu Asn Leu Glu Lys Ala Leu Asn Ile Asn Thr Leu Cys Leu Asn Asn 
    130                 135                 140                 


Ile Ile Ala Leu Ala Gln Tyr Asn Val Ala Ala Gln Thr Pro Val Met 
145                 150                 155                 160 


Gln Ile Ser Thr Cys Tyr Val Asn Gly Phe Asn Lys Gly Gln Ile Asn 
                165                 170                 175     


Glu Glu Val Val Gly Pro Ala Ser Gly Leu Ile Pro Gln Leu Ser Gln 
            180                 185                 190         


Asp Cys Tyr Asp Ile Asp Ser Val Phe Lys Arg Val His Ser Gln Ile 
        195                 200                 205             


Glu Gln Val Lys Lys Arg Lys Thr Asp Ile Glu Gln Gln Glu Gln Ala 
    210                 215                 220                 


Leu Ile Lys Leu Gly Ile Lys Thr Ser Gln His Phe Gly Trp Asn Asp 
225                 230                 235                 240 


Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln Leu Leu Ile Gln Lys 
                245                 250                 255     


Leu Gly Lys Gln Ser Leu Thr Ile Leu Arg Pro Ser Ile Ile Glu Ser 
            260                 265                 270         


Ala Val Arg Glu Pro Ala Pro Gly Trp Val Glu Gly Val Lys Val Ala 
        275                 280                 285             


Asp Ala Leu Ile Tyr Ala Tyr Ala Lys Gly Arg Val Ser Ile Phe Pro 
    290                 295                 300                 


Gly Arg Asp Glu Gly Ile Leu Asp Val Ile Pro Val Asp Leu Val Ala 
305                 310                 315                 320 


Asn Ala Ala Ala Leu Ser Ala Ala Gln Leu Met Glu Ser Asn Gln Gln 
                325                 330                 335     


Thr Gly Tyr Arg Ile Tyr Gln Cys Cys Ser Gly Ser Arg Asn Pro Ile 
            340                 345                 350         


Lys Leu Lys Glu Phe Ile Arg His Ile Gln Asn Val Ala Gln Ala Arg 
        355                 360                 365             


Tyr Gln Glu Trp Pro Lys Leu Phe Ala Asp Lys Pro Gln Glu Ala Phe 
    370                 375                 380                 


Lys Thr Val Ser Pro Lys Arg Phe Lys Leu Tyr Met Ser Gly Phe Thr 
385                 390                 395                 400 


Ala Ile Thr Trp Ala Lys Thr Ile Ile Gly Arg Val Phe Gly Ser Asn 
                405                 410                 415     


Ala Ala Ser Gln His Met Leu Lys Ala Lys Thr Thr Ala Ser Leu Ala 
            420                 425                 430         


Asn Ile Phe Gly Phe Tyr Thr Ala Pro Asn Tyr Arg Phe Ser Ser Gln 
        435                 440                 445             


Lys Leu Glu Gln Leu Val Lys Gln Phe Asp Thr Thr Glu Gln Arg Leu 
    450                 455                 460                 


Tyr Asp Ile Arg Ala Asp His Phe Asp Trp Lys Tyr Tyr Leu Gln Glu 
465                 470                 475                 480 


Val His Met Asp Gly Leu His Lys Tyr Ala Leu Ala Asp Arg Gln Glu 
                485                 490                 495     


Leu Lys Pro Lys His Val Lys Lys Arg Lys Arg Glu Thr Ile Arg Gln 
            500                 505                 510         


Ala Ala 
        


<210>  9
<211>  1383
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1383)

<400>  9
atg tcc cac aat ggt act ctt gat gag cat tat cag aca gtt cgt gaa         48
Met Ser His Asn Gly Thr Leu Asp Glu His Tyr Gln Thr Val Arg Glu           
1               5                   10                  15                

ttt tat gac ggt aag agc gtt ttt att act ggc gcc act ggc ttt ctt         96
Phe Tyr Asp Gly Lys Ser Val Phe Ile Thr Gly Ala Thr Gly Phe Leu           
            20                  25                  30                    

gga aaa gcc tac gtt gag aaa ctg gca tat tct tgt ccc gga att gtc        144
Gly Lys Ala Tyr Val Glu Lys Leu Ala Tyr Ser Cys Pro Gly Ile Val           
        35                  40                  45                        

tct att tat att ttg att cgt gat aaa aag ggc tcc aac acg gag gag        192
Ser Ile Tyr Ile Leu Ile Arg Asp Lys Lys Gly Ser Asn Thr Glu Glu           
    50                  55                  60                            

cgt atg cgt aaa tat ttg gac caa ccc att ttc tct cgt att aaa tat        240
Arg Met Arg Lys Tyr Leu Asp Gln Pro Ile Phe Ser Arg Ile Lys Tyr           
65                  70                  75                  80            

gag cat cca gag tac ttc aaa aag att atc ccc att tct ggc gat att        288
Glu His Pro Glu Tyr Phe Lys Lys Ile Ile Pro Ile Ser Gly Asp Ile           
                85                  90                  95                

acc gcc cct aaa ctt ggt ctt tgc gac gag gag cgt aac atc ctg att        336
Thr Ala Pro Lys Leu Gly Leu Cys Asp Glu Glu Arg Asn Ile Leu Ile           
            100                 105                 110                   

aat gaa gtg tcc atc gtt atc cac tct gct gcc agc gtt aaa ctg aac        384
Asn Glu Val Ser Ile Val Ile His Ser Ala Ala Ser Val Lys Leu Asn           
        115                 120                 125                       

gat cat ctt aaa ttc acc ttg aac acc aac gtt ggt ggt act atg aaa        432
Asp His Leu Lys Phe Thr Leu Asn Thr Asn Val Gly Gly Thr Met Lys           
    130                 135                 140                           

gtc ttg gag ctt gtt aag gag atg aaa aat ttg gcg atg ttt gtg tac        480
Val Leu Glu Leu Val Lys Glu Met Lys Asn Leu Ala Met Phe Val Tyr           
145                 150                 155                 160           

gtt tct acg gct tat tct aac acc agc caa cgt att ttg gaa gaa aaa        528
Val Ser Thr Ala Tyr Ser Asn Thr Ser Gln Arg Ile Leu Glu Glu Lys           
                165                 170                 175               

ttg tac cct cag tct ctg aat ttg aac gaa att cag aaa ttc gct gaa        576
Leu Tyr Pro Gln Ser Leu Asn Leu Asn Glu Ile Gln Lys Phe Ala Glu           
            180                 185                 190                   

gag cac tac att ctg ggt aag gat aac gac gaa atg att aaa ttc att        624
Glu His Tyr Ile Leu Gly Lys Asp Asn Asp Glu Met Ile Lys Phe Ile           
        195                 200                 205                       

gga aac cat cct aac act tac gcc tac acg aaa gcc ctg gct gag aat        672
Gly Asn His Pro Asn Thr Tyr Ala Tyr Thr Lys Ala Leu Ala Glu Asn           
    210                 215                 220                           

ctt gtc gct gaa gaa cat gga gaa att cct act att att att cgt cct        720
Leu Val Ala Glu Glu His Gly Glu Ile Pro Thr Ile Ile Ile Arg Pro           
225                 230                 235                 240           

tct atc atc aca gcc tcc gcc gag gaa ccc gtt cgt gga ttt gtt gat        768
Ser Ile Ile Thr Ala Ser Ala Glu Glu Pro Val Arg Gly Phe Val Asp           
                245                 250                 255               

tct tgg agc gga gcc acg gct atg gct gca ttt gca ctt aaa ggc tgg        816
Ser Trp Ser Gly Ala Thr Ala Met Ala Ala Phe Ala Leu Lys Gly Trp           
            260                 265                 270                   

aac aac atc atg tat tcc acc ggt gaa gag aac att gac ttg atc ccc        864
Asn Asn Ile Met Tyr Ser Thr Gly Glu Glu Asn Ile Asp Leu Ile Pro           
        275                 280                 285                       

ctg gat tac gtt gtc aac ttg aca ctg gtg gct att gct aaa tat aag        912
Leu Asp Tyr Val Val Asn Leu Thr Leu Val Ala Ile Ala Lys Tyr Lys           
    290                 295                 300                           

cca acg aaa gag gtt acg gtg tac cat gtt aca acg agc gac ttg aac        960
Pro Thr Lys Glu Val Thr Val Tyr His Val Thr Thr Ser Asp Leu Asn           
305                 310                 315                 320           

ccg att agc atc cgt cgt att ttc atc aaa ctg agc gag ttc gcc tcc       1008
Pro Ile Ser Ile Arg Arg Ile Phe Ile Lys Leu Ser Glu Phe Ala Ser           
                325                 330                 335               

aaa aac cca act agc aac gct gcc cca ttc gct gcc act aca ttg ctg       1056
Lys Asn Pro Thr Ser Asn Ala Ala Pro Phe Ala Ala Thr Thr Leu Leu           
            340                 345                 350                   

acc aaa cag aaa ccg ctt att aaa ctg gtg aca ttt ctt atg cag acc       1104
Thr Lys Gln Lys Pro Leu Ile Lys Leu Val Thr Phe Leu Met Gln Thr           
        355                 360                 365                       

aca cca gct ttt ttg gca gac ttg tgg atg aaa acg cag cgt aaa gag       1152
Thr Pro Ala Phe Leu Ala Asp Leu Trp Met Lys Thr Gln Arg Lys Glu           
    370                 375                 380                           

gcc aag ttc gtg aaa cag cac aac ttg gtc gtt cgt tct cgt gat cag       1200
Ala Lys Phe Val Lys Gln His Asn Leu Val Val Arg Ser Arg Asp Gln           
385                 390                 395                 400           

ctg gag ttc ttt aca tct cag agc tgg ctt ttg cgt tgt gag cgt gca       1248
Leu Glu Phe Phe Thr Ser Gln Ser Trp Leu Leu Arg Cys Glu Arg Ala           
                405                 410                 415               

cgt gtc ctg tcc gcg gcc ttg tcc gat tcc gac cgt gct gtc ttc cgt       1296
Arg Val Leu Ser Ala Ala Leu Ser Asp Ser Asp Arg Ala Val Phe Arg           
            420                 425                 430                   

tgc gat cct tcc acg att gat tgg gat cag tat ctt cct atc tac ttc       1344
Cys Asp Pro Ser Thr Ile Asp Trp Asp Gln Tyr Leu Pro Ile Tyr Phe           
        435                 440                 445                       

gaa ggt att aat aaa cac ctg ttc aaa aat aag ttg tag                   1383
Glu Gly Ile Asn Lys His Leu Phe Lys Asn Lys Leu                           
    450                 455                 460                           


<210>  10
<211>  460
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Met Ser His Asn Gly Thr Leu Asp Glu His Tyr Gln Thr Val Arg Glu 
1               5                   10                  15      


Phe Tyr Asp Gly Lys Ser Val Phe Ile Thr Gly Ala Thr Gly Phe Leu 
            20                  25                  30          


Gly Lys Ala Tyr Val Glu Lys Leu Ala Tyr Ser Cys Pro Gly Ile Val 
        35                  40                  45              


Ser Ile Tyr Ile Leu Ile Arg Asp Lys Lys Gly Ser Asn Thr Glu Glu 
    50                  55                  60                  


Arg Met Arg Lys Tyr Leu Asp Gln Pro Ile Phe Ser Arg Ile Lys Tyr 
65                  70                  75                  80  


Glu His Pro Glu Tyr Phe Lys Lys Ile Ile Pro Ile Ser Gly Asp Ile 
                85                  90                  95      


Thr Ala Pro Lys Leu Gly Leu Cys Asp Glu Glu Arg Asn Ile Leu Ile 
            100                 105                 110         


Asn Glu Val Ser Ile Val Ile His Ser Ala Ala Ser Val Lys Leu Asn 
        115                 120                 125             


Asp His Leu Lys Phe Thr Leu Asn Thr Asn Val Gly Gly Thr Met Lys 
    130                 135                 140                 


Val Leu Glu Leu Val Lys Glu Met Lys Asn Leu Ala Met Phe Val Tyr 
145                 150                 155                 160 


Val Ser Thr Ala Tyr Ser Asn Thr Ser Gln Arg Ile Leu Glu Glu Lys 
                165                 170                 175     


Leu Tyr Pro Gln Ser Leu Asn Leu Asn Glu Ile Gln Lys Phe Ala Glu 
            180                 185                 190         


Glu His Tyr Ile Leu Gly Lys Asp Asn Asp Glu Met Ile Lys Phe Ile 
        195                 200                 205             


Gly Asn His Pro Asn Thr Tyr Ala Tyr Thr Lys Ala Leu Ala Glu Asn 
    210                 215                 220                 


Leu Val Ala Glu Glu His Gly Glu Ile Pro Thr Ile Ile Ile Arg Pro 
225                 230                 235                 240 


Ser Ile Ile Thr Ala Ser Ala Glu Glu Pro Val Arg Gly Phe Val Asp 
                245                 250                 255     


Ser Trp Ser Gly Ala Thr Ala Met Ala Ala Phe Ala Leu Lys Gly Trp 
            260                 265                 270         


Asn Asn Ile Met Tyr Ser Thr Gly Glu Glu Asn Ile Asp Leu Ile Pro 
        275                 280                 285             


Leu Asp Tyr Val Val Asn Leu Thr Leu Val Ala Ile Ala Lys Tyr Lys 
    290                 295                 300                 


Pro Thr Lys Glu Val Thr Val Tyr His Val Thr Thr Ser Asp Leu Asn 
305                 310                 315                 320 


Pro Ile Ser Ile Arg Arg Ile Phe Ile Lys Leu Ser Glu Phe Ala Ser 
                325                 330                 335     


Lys Asn Pro Thr Ser Asn Ala Ala Pro Phe Ala Ala Thr Thr Leu Leu 
            340                 345                 350         


Thr Lys Gln Lys Pro Leu Ile Lys Leu Val Thr Phe Leu Met Gln Thr 
        355                 360                 365             


Thr Pro Ala Phe Leu Ala Asp Leu Trp Met Lys Thr Gln Arg Lys Glu 
    370                 375                 380                 


Ala Lys Phe Val Lys Gln His Asn Leu Val Val Arg Ser Arg Asp Gln 
385                 390                 395                 400 


Leu Glu Phe Phe Thr Ser Gln Ser Trp Leu Leu Arg Cys Glu Arg Ala 
                405                 410                 415     


Arg Val Leu Ser Ala Ala Leu Ser Asp Ser Asp Arg Ala Val Phe Arg 
            420                 425                 430         


Cys Asp Pro Ser Thr Ile Asp Trp Asp Gln Tyr Leu Pro Ile Tyr Phe 
        435                 440                 445             


Glu Gly Ile Asn Lys His Leu Phe Lys Asn Lys Leu 
    450                 455                 460 


<210>  11
<211>  1380
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1380)

<400>  11
atg tct cac aac gga act ctt gac gag cat tac caa act gtg cga gag         48
Met Ser His Asn Gly Thr Leu Asp Glu His Tyr Gln Thr Val Arg Glu           
1               5                   10                  15                

ttc tac gac ggc aaa tcc gtg ttc atc acc gga gcc act gga ttt ctt         96
Phe Tyr Asp Gly Lys Ser Val Phe Ile Thr Gly Ala Thr Gly Phe Leu           
            20                  25                  30                    

ggt aag gca tac gtg gag aag ctc gct tac agc tgt ccc ggt atc gtt        144
Gly Lys Ala Tyr Val Glu Lys Leu Ala Tyr Ser Cys Pro Gly Ile Val           
        35                  40                  45                        

tct atc tac atc ctg att aga gat aag aag ggc tcc aac aca gaa gag        192
Ser Ile Tyr Ile Leu Ile Arg Asp Lys Lys Gly Ser Asn Thr Glu Glu           
    50                  55                  60                            

cgg atg cga aag tac ctg gac cag ccc atc ttc tcc cgg atc aag tac        240
Arg Met Arg Lys Tyr Leu Asp Gln Pro Ile Phe Ser Arg Ile Lys Tyr           
65                  70                  75                  80            

gaa cac cct gag tac ttc aag aag atc atc ccc att agc gga gac att        288
Glu His Pro Glu Tyr Phe Lys Lys Ile Ile Pro Ile Ser Gly Asp Ile           
                85                  90                  95                

act gcc cca aag ctg ggc ttg tgt gac gag gag cgg aac atc ctg atc        336
Thr Ala Pro Lys Leu Gly Leu Cys Asp Glu Glu Arg Asn Ile Leu Ile           
            100                 105                 110                   

aac gag gtg tcc atc gtg att cat tcc gcc gcc tct gtt aag ctg aac        384
Asn Glu Val Ser Ile Val Ile His Ser Ala Ala Ser Val Lys Leu Asn           
        115                 120                 125                       

gac cac ctg aag ttc acc ctg aac act aac gtg ggt gga acg atg aag        432
Asp His Leu Lys Phe Thr Leu Asn Thr Asn Val Gly Gly Thr Met Lys           
    130                 135                 140                           

gtc ctg gag ctg gtg aag gag atg aag aac ctg gcc atg ttc gtg tac        480
Val Leu Glu Leu Val Lys Glu Met Lys Asn Leu Ala Met Phe Val Tyr           
145                 150                 155                 160           

gtg tcc acc gct tac tcc aac acc tct cag aga atc ctg gag gag aag        528
Val Ser Thr Ala Tyr Ser Asn Thr Ser Gln Arg Ile Leu Glu Glu Lys           
                165                 170                 175               

ctg tac cct cag tcc ctg aac ctg aac gag atc cag aag ttc gcc gag        576
Leu Tyr Pro Gln Ser Leu Asn Leu Asn Glu Ile Gln Lys Phe Ala Glu           
            180                 185                 190                   

gaa cac tac atc ctg ggc aag gac aac gac gag atg atc aag ttc atc        624
Glu His Tyr Ile Leu Gly Lys Asp Asn Asp Glu Met Ile Lys Phe Ile           
        195                 200                 205                       

ggc aac cac ccc aac acc tac gct tac acc aaa gcc ctg gct gag aac        672
Gly Asn His Pro Asn Thr Tyr Ala Tyr Thr Lys Ala Leu Ala Glu Asn           
    210                 215                 220                           

ctt gtt gcc gaa gag cat gga gag atc ccc acc atc atc atc cga ccc        720
Leu Val Ala Glu Glu His Gly Glu Ile Pro Thr Ile Ile Ile Arg Pro           
225                 230                 235                 240           

tct atc att act gca tcc gcg gag gag cct gtg cga ggc ttc gtc gat        768
Ser Ile Ile Thr Ala Ser Ala Glu Glu Pro Val Arg Gly Phe Val Asp           
                245                 250                 255               

tct tgg tct ggc gct act gct atg gct gct ttc gct ctc aag gga tgg        816
Ser Trp Ser Gly Ala Thr Ala Met Ala Ala Phe Ala Leu Lys Gly Trp           
            260                 265                 270                   

aac aac atc atg tat tcc acc ggc gaa gag aac att gac ctg atc cct        864
Asn Asn Ile Met Tyr Ser Thr Gly Glu Glu Asn Ile Asp Leu Ile Pro           
        275                 280                 285                       

ctc gac tac gtg gtg aac ctt acc ctg gtg gcc atc gct aag tac aag        912
Leu Asp Tyr Val Val Asn Leu Thr Leu Val Ala Ile Ala Lys Tyr Lys           
    290                 295                 300                           

cct acc aaa gag gtg acc gtg tac cac gtc acg act tcg gat ctg aat        960
Pro Thr Lys Glu Val Thr Val Tyr His Val Thr Thr Ser Asp Leu Asn           
305                 310                 315                 320           

ccc atc tcc atc cgg cga atc ttc atc aag ctg tct gag ttt gct tct       1008
Pro Ile Ser Ile Arg Arg Ile Phe Ile Lys Leu Ser Glu Phe Ala Ser           
                325                 330                 335               

aag aac ccg act tct aat gct gct cct ttc gct gcc act act ctg ctt       1056
Lys Asn Pro Thr Ser Asn Ala Ala Pro Phe Ala Ala Thr Thr Leu Leu           
            340                 345                 350                   

acc aag cag aaa ccc ctg atc aag ctg gtt acg ttt ctg atg caa acc       1104
Thr Lys Gln Lys Pro Leu Ile Lys Leu Val Thr Phe Leu Met Gln Thr           
        355                 360                 365                       

act cct gcc ttc ctc gct gac ctg tgg atg aag acc cag cga aag gag       1152
Thr Pro Ala Phe Leu Ala Asp Leu Trp Met Lys Thr Gln Arg Lys Glu           
    370                 375                 380                           

gcc aag ttc gtc aaa cag cat aac ctc gtc gtt aga tcg cga gat cag       1200
Ala Lys Phe Val Lys Gln His Asn Leu Val Val Arg Ser Arg Asp Gln           
385                 390                 395                 400           

ttg gag ttc ttt acc tcc cag tcc tgg ctg ctt cgt tgt gaa aga gcc       1248
Leu Glu Phe Phe Thr Ser Gln Ser Trp Leu Leu Arg Cys Glu Arg Ala           
                405                 410                 415               

aga gtg ctg tct gct gct ctt agc gac tct gat cgt gcc gtg ttt aga       1296
Arg Val Leu Ser Ala Ala Leu Ser Asp Ser Asp Arg Ala Val Phe Arg           
            420                 425                 430                   

tgt gac ccc tcg aca atc gac tgg gat cag tac ctg ccc atc tac ttc       1344
Cys Asp Pro Ser Thr Ile Asp Trp Asp Gln Tyr Leu Pro Ile Tyr Phe           
        435                 440                 445                       

gag ggc atc aac aag cac ctg ttc aag aac aag ctc                       1380
Glu Gly Ile Asn Lys His Leu Phe Lys Asn Lys Leu                           
    450                 455                 460                           


<210>  12
<211>  460
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  12

Met Ser His Asn Gly Thr Leu Asp Glu His Tyr Gln Thr Val Arg Glu 
1               5                   10                  15      


Phe Tyr Asp Gly Lys Ser Val Phe Ile Thr Gly Ala Thr Gly Phe Leu 
            20                  25                  30          


Gly Lys Ala Tyr Val Glu Lys Leu Ala Tyr Ser Cys Pro Gly Ile Val 
        35                  40                  45              


Ser Ile Tyr Ile Leu Ile Arg Asp Lys Lys Gly Ser Asn Thr Glu Glu 
    50                  55                  60                  


Arg Met Arg Lys Tyr Leu Asp Gln Pro Ile Phe Ser Arg Ile Lys Tyr 
65                  70                  75                  80  


Glu His Pro Glu Tyr Phe Lys Lys Ile Ile Pro Ile Ser Gly Asp Ile 
                85                  90                  95      


Thr Ala Pro Lys Leu Gly Leu Cys Asp Glu Glu Arg Asn Ile Leu Ile 
            100                 105                 110         


Asn Glu Val Ser Ile Val Ile His Ser Ala Ala Ser Val Lys Leu Asn 
        115                 120                 125             


Asp His Leu Lys Phe Thr Leu Asn Thr Asn Val Gly Gly Thr Met Lys 
    130                 135                 140                 


Val Leu Glu Leu Val Lys Glu Met Lys Asn Leu Ala Met Phe Val Tyr 
145                 150                 155                 160 


Val Ser Thr Ala Tyr Ser Asn Thr Ser Gln Arg Ile Leu Glu Glu Lys 
                165                 170                 175     


Leu Tyr Pro Gln Ser Leu Asn Leu Asn Glu Ile Gln Lys Phe Ala Glu 
            180                 185                 190         


Glu His Tyr Ile Leu Gly Lys Asp Asn Asp Glu Met Ile Lys Phe Ile 
        195                 200                 205             


Gly Asn His Pro Asn Thr Tyr Ala Tyr Thr Lys Ala Leu Ala Glu Asn 
    210                 215                 220                 


Leu Val Ala Glu Glu His Gly Glu Ile Pro Thr Ile Ile Ile Arg Pro 
225                 230                 235                 240 


Ser Ile Ile Thr Ala Ser Ala Glu Glu Pro Val Arg Gly Phe Val Asp 
                245                 250                 255     


Ser Trp Ser Gly Ala Thr Ala Met Ala Ala Phe Ala Leu Lys Gly Trp 
            260                 265                 270         


Asn Asn Ile Met Tyr Ser Thr Gly Glu Glu Asn Ile Asp Leu Ile Pro 
        275                 280                 285             


Leu Asp Tyr Val Val Asn Leu Thr Leu Val Ala Ile Ala Lys Tyr Lys 
    290                 295                 300                 


Pro Thr Lys Glu Val Thr Val Tyr His Val Thr Thr Ser Asp Leu Asn 
305                 310                 315                 320 


Pro Ile Ser Ile Arg Arg Ile Phe Ile Lys Leu Ser Glu Phe Ala Ser 
                325                 330                 335     


Lys Asn Pro Thr Ser Asn Ala Ala Pro Phe Ala Ala Thr Thr Leu Leu 
            340                 345                 350         


Thr Lys Gln Lys Pro Leu Ile Lys Leu Val Thr Phe Leu Met Gln Thr 
        355                 360                 365             


Thr Pro Ala Phe Leu Ala Asp Leu Trp Met Lys Thr Gln Arg Lys Glu 
    370                 375                 380                 


Ala Lys Phe Val Lys Gln His Asn Leu Val Val Arg Ser Arg Asp Gln 
385                 390                 395                 400 


Leu Glu Phe Phe Thr Ser Gln Ser Trp Leu Leu Arg Cys Glu Arg Ala 
                405                 410                 415     


Arg Val Leu Ser Ala Ala Leu Ser Asp Ser Asp Arg Ala Val Phe Arg 
            420                 425                 430         


Cys Asp Pro Ser Thr Ile Asp Trp Asp Gln Tyr Leu Pro Ile Tyr Phe 
        435                 440                 445             


Glu Gly Ile Asn Lys His Leu Phe Lys Asn Lys Leu 
    450                 455                 460 


<210>  13
<211>  1542
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1542)

<400>  13
atg gct atc cag cag gtt cat cac gcc gac aca tcc tcc tct aaa gtc         48
Met Ala Ile Gln Gln Val His His Ala Asp Thr Ser Ser Ser Lys Val           
1               5                   10                  15                

ctg ggt caa ctt cgt ggt aaa cgt gtc ttg att acc ggc act act gga         96
Leu Gly Gln Leu Arg Gly Lys Arg Val Leu Ile Thr Gly Thr Thr Gly           
            20                  25                  30                    

ttc ttg ggt aaa gtc gtc ttg gaa cgt ttg att cgt gcc gtt cct gac        144
Phe Leu Gly Lys Val Val Leu Glu Arg Leu Ile Arg Ala Val Pro Asp           
        35                  40                  45                        

atc ggt gct atc tac ctg ctg att cgt ggt aac aag cgt cac ccg gat        192
Ile Gly Ala Ile Tyr Leu Leu Ile Arg Gly Asn Lys Arg His Pro Asp           
    50                  55                  60                            

gct cgt tct cgt ttc ttg gag gag att gct acc tcc tct gtc ttt gat        240
Ala Arg Ser Arg Phe Leu Glu Glu Ile Ala Thr Ser Ser Val Phe Asp           
65                  70                  75                  80            

cgt ttg cgt gaa gct gat tcc gaa ggt ttc gat gct ttc ctg gaa gaa        288
Arg Leu Arg Glu Ala Asp Ser Glu Gly Phe Asp Ala Phe Leu Glu Glu           
                85                  90                  95                

cgt att cac tgt gtt act ggt gaa gtt act gaa gct ggt ttc ggt att        336
Arg Ile His Cys Val Thr Gly Glu Val Thr Glu Ala Gly Phe Gly Ile           
            100                 105                 110                   

ggt caa gag gac tat cgt aag ttg gcc acc gaa ttg gac gca gtc atc        384
Gly Gln Glu Asp Tyr Arg Lys Leu Ala Thr Glu Leu Asp Ala Val Ile           
        115                 120                 125                       

aat tct gct gcc tcc gtc aac ttc cgt gag gag ttg gat aag gct ctg        432
Asn Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu           
    130                 135                 140                           

gcc atc aac act ctg tgt ttg cgt aac atc gct ggt atg gtg gat ctt        480
Ala Ile Asn Thr Leu Cys Leu Arg Asn Ile Ala Gly Met Val Asp Leu           
145                 150                 155                 160           

aac cct aag ctg gcc gtt ctt caa gtc tct acg tgt tac gtc aac ggt        528
Asn Pro Lys Leu Ala Val Leu Gln Val Ser Thr Cys Tyr Val Asn Gly           
                165                 170                 175               

atg aac tct ggt caa gtt act gaa tcc gtc atc aaa cca gct ggt gaa        576
Met Asn Ser Gly Gln Val Thr Glu Ser Val Ile Lys Pro Ala Gly Glu           
            180                 185                 190                   

gct gtt cct cgt tct cct gat gga ttc tac gag atc gag gaa ttg gtt        624
Ala Val Pro Arg Ser Pro Asp Gly Phe Tyr Glu Ile Glu Glu Leu Val           
        195                 200                 205                       

cgt ctg ctg caa gac aag att gaa gac gtt caa gca cgt tac tct ggt        672
Arg Leu Leu Gln Asp Lys Ile Glu Asp Val Gln Ala Arg Tyr Ser Gly           
    210                 215                 220                           

aag gtg ttg gag cgt aag ttg gtt gat ttg ggt att cgt gag gct aat        720
Lys Val Leu Glu Arg Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn           
225                 230                 235                 240           

cgt tac ggt tgg tct gat aca tac acc ttc acg aaa tgg ttg ggt gaa        768
Arg Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu           
                245                 250                 255               

caa ctt ctg atg aaa gcc ttg aat ggt cgt acc ttg act att ctg cgt        816
Gln Leu Leu Met Lys Ala Leu Asn Gly Arg Thr Leu Thr Ile Leu Arg           
            260                 265                 270                   

cct agc atc att gaa tct gct ttg gaa gaa cca gca cct ggt tgg att        864
Pro Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ala Pro Gly Trp Ile           
        275                 280                 285                       

gaa ggc gtg aaa gtt gca gat gcg atc atc ttg gct tat gct cgt gag        912
Glu Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu           
    290                 295                 300                           

aag gtt act ttg ttt ccg ggt aaa cgt tct ggt atc att gat gtg att        960
Lys Val Thr Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile           
305                 310                 315                 320           

cct gtt gac ttg gtt gcc aat tcc atc atc ttg tct ttg gct gag gct       1008
Pro Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala           
                325                 330                 335               

ctg ggc gaa cct ggt cgt cgt cgt atc tac caa tgt tgt tct ggt ggt       1056
Leu Gly Glu Pro Gly Arg Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly           
            340                 345                 350                   

ggt aat cct atc tcc ctg ggc gag ttc att gat cac ctg atg gct gaa       1104
Gly Asn Pro Ile Ser Leu Gly Glu Phe Ile Asp His Leu Met Ala Glu           
        355                 360                 365                       

tcc aaa gcc aac tat gcc gca tac gat cat ctg ttc tac cgt caa ccc       1152
Ser Lys Ala Asn Tyr Ala Ala Tyr Asp His Leu Phe Tyr Arg Gln Pro           
    370                 375                 380                           

tcc aag cct ttc ctt gct gtc aac cgt gct ttg ttc gac ttg gtt atc       1200
Ser Lys Pro Phe Leu Ala Val Asn Arg Ala Leu Phe Asp Leu Val Ile           
385                 390                 395                 400           

tct ggt gtc cgt ctg cct ttg tct ttg acc gac cgt gtc ttg aag ctg       1248
Ser Gly Val Arg Leu Pro Leu Ser Leu Thr Asp Arg Val Leu Lys Leu           
                405                 410                 415               

ctg ggc aac tcc cgt gac ctg aag atg ctg cgt aac ctg gat act acg       1296
Leu Gly Asn Ser Arg Asp Leu Lys Met Leu Arg Asn Leu Asp Thr Thr           
            420                 425                 430                   

caa tcc ctg gct act atc ttt ggc ttc tac aca gcc ccc gac tac atc       1344
Gln Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile           
        435                 440                 445                       

ttc cgt aat gac gag ttg atg gcc ctg gct aac cgt atg ggc gag gtt       1392
Phe Arg Asn Asp Glu Leu Met Ala Leu Ala Asn Arg Met Gly Glu Val           
    450                 455                 460                           

gat aag ggt ttg ttc ccc gtt gat gct cgt ctg att gat tgg gaa ttg       1440
Asp Lys Gly Leu Phe Pro Val Asp Ala Arg Leu Ile Asp Trp Glu Leu           
465                 470                 475                 480           

tac ctg cgt aag att cac ctg gct ggt ttg aac cgt tac gcc ttg aag       1488
Tyr Leu Arg Lys Ile His Leu Ala Gly Leu Asn Arg Tyr Ala Leu Lys           
                485                 490                 495               

gag cgt aag gtt tac tct ttg aag aca gcc cgt cag cgt aag aag gca       1536
Glu Arg Lys Val Tyr Ser Leu Lys Thr Ala Arg Gln Arg Lys Lys Ala           
            500                 505                 510                   

gct taa                                                               1542
Ala                                                                       
                                                                          


<210>  14
<211>  513
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Met Ala Ile Gln Gln Val His His Ala Asp Thr Ser Ser Ser Lys Val 
1               5                   10                  15      


Leu Gly Gln Leu Arg Gly Lys Arg Val Leu Ile Thr Gly Thr Thr Gly 
            20                  25                  30          


Phe Leu Gly Lys Val Val Leu Glu Arg Leu Ile Arg Ala Val Pro Asp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Leu Leu Ile Arg Gly Asn Lys Arg His Pro Asp 
    50                  55                  60                  


Ala Arg Ser Arg Phe Leu Glu Glu Ile Ala Thr Ser Ser Val Phe Asp 
65                  70                  75                  80  


Arg Leu Arg Glu Ala Asp Ser Glu Gly Phe Asp Ala Phe Leu Glu Glu 
                85                  90                  95      


Arg Ile His Cys Val Thr Gly Glu Val Thr Glu Ala Gly Phe Gly Ile 
            100                 105                 110         


Gly Gln Glu Asp Tyr Arg Lys Leu Ala Thr Glu Leu Asp Ala Val Ile 
        115                 120                 125             


Asn Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu 
    130                 135                 140                 


Ala Ile Asn Thr Leu Cys Leu Arg Asn Ile Ala Gly Met Val Asp Leu 
145                 150                 155                 160 


Asn Pro Lys Leu Ala Val Leu Gln Val Ser Thr Cys Tyr Val Asn Gly 
                165                 170                 175     


Met Asn Ser Gly Gln Val Thr Glu Ser Val Ile Lys Pro Ala Gly Glu 
            180                 185                 190         


Ala Val Pro Arg Ser Pro Asp Gly Phe Tyr Glu Ile Glu Glu Leu Val 
        195                 200                 205             


Arg Leu Leu Gln Asp Lys Ile Glu Asp Val Gln Ala Arg Tyr Ser Gly 
    210                 215                 220                 


Lys Val Leu Glu Arg Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn 
225                 230                 235                 240 


Arg Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu 
                245                 250                 255     


Gln Leu Leu Met Lys Ala Leu Asn Gly Arg Thr Leu Thr Ile Leu Arg 
            260                 265                 270         


Pro Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ala Pro Gly Trp Ile 
        275                 280                 285             


Glu Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu 
    290                 295                 300                 


Lys Val Thr Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile 
305                 310                 315                 320 


Pro Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala 
                325                 330                 335     


Leu Gly Glu Pro Gly Arg Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly 
            340                 345                 350         


Gly Asn Pro Ile Ser Leu Gly Glu Phe Ile Asp His Leu Met Ala Glu 
        355                 360                 365             


Ser Lys Ala Asn Tyr Ala Ala Tyr Asp His Leu Phe Tyr Arg Gln Pro 
    370                 375                 380                 


Ser Lys Pro Phe Leu Ala Val Asn Arg Ala Leu Phe Asp Leu Val Ile 
385                 390                 395                 400 


Ser Gly Val Arg Leu Pro Leu Ser Leu Thr Asp Arg Val Leu Lys Leu 
                405                 410                 415     


Leu Gly Asn Ser Arg Asp Leu Lys Met Leu Arg Asn Leu Asp Thr Thr 
            420                 425                 430         


Gln Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile 
        435                 440                 445             


Phe Arg Asn Asp Glu Leu Met Ala Leu Ala Asn Arg Met Gly Glu Val 
    450                 455                 460                 


Asp Lys Gly Leu Phe Pro Val Asp Ala Arg Leu Ile Asp Trp Glu Leu 
465                 470                 475                 480 


Tyr Leu Arg Lys Ile His Leu Ala Gly Leu Asn Arg Tyr Ala Leu Lys 
                485                 490                 495     


Glu Arg Lys Val Tyr Ser Leu Lys Thr Ala Arg Gln Arg Lys Lys Ala 
            500                 505                 510         


Ala 
    


<210>  15
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  15
acaatctgga tccggccagc ctggccataa ggagatatac at                          42


<210>  16
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  16
taatgaggcc aaactggccg tcgacaccag tatg                                   34


<210>  17
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  17
agagaccggg ttggcgg                                                      17


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  18
catttgccat tcgtaacgct g                                                 21


