                         SEQUENCE LISTING

<110>  GEORGIOU, GEORGE
       STONE, EVERETT
 
<120>  ARGINASE FORMULATIONS AND METHODS

<130>  UTFB.P0739WO

<140>  UNKNOWN
<141>  2010-06-28

<150>  61/221,396
<151>  2009-06-29

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Cys Ser His His His His His His Ser Ser Gly Ser Ala Lys 
1               5                   10                  15      


Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro 
            20                  25                  30          


Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu 
        35                  40                  45              


Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp 
    50                  55                  60                  


Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys 
65                  70                  75                  80  


Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val 
                85                  90                  95      


Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp 
            100                 105                 110         


His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro 
        115                 120                 125             


Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro 
    130                 135                 140                 


Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu 
145                 150                 155                 160 


Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp 
                165                 170                 175     


Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg 
            180                 185                 190         


Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys 
        195                 200                 205             


Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met 
    210                 215                 220                 


Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His 
225                 230                 235                 240 


Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr 
                245                 250                 255     


Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile 
            260                 265                 270         


Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met 
        275                 280                 285             


Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr 
    290                 295                 300                 


Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg 
305                 310                 315                 320 


Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
                325                 330                 


<210>  2
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  2
atgggttgtt ctcaccatca tcaccaccac agctctggct ctgcgaagag ccgtacgatc       60

ggcattattg gtgcgccgtt ctctaaaggt cagccacgcg gtggtgtgga agagggtccg      120

acggttctgc gtaaggccgg tttattagaa aagctgaaag agcaggagtg cgacgttaag      180

gactacggtg acttaccatt cgcggacatc ccgaatgata gcccgttcca aatcgttaag      240

aatccgcgct ctgtgggtaa agcaagcgag cagttagcag gtaaggtggc cgaggtcaag      300

aaaaacggtc gtattagcct ggttttaggc ggtgatcata gcttagcaat tggctctatc      360

tctggtcatg cccgtgtgca cccagattta ggtgtcattt gggttgacgc ccatacggat      420

atcaatacgc cattaacgac caccagcggc aatctgcatg gccagccggt tagcttctta      480

ctgaaggagc tgaagggtaa aattccagat gttccgggct ttagctgggt cacgccatgt      540

atttctgcca aggatatcgt gtacattggc ttacgtgacg tcgacccagg tgagcactac      600

atcttaaaga ccctgggtat caagtatttc agcatgacgg aagtggaccg cttaggcatc      660

ggcaaggtga tggaggagac gctgagctat ctgctgggcc gtaagaaacg tccaatccat      720

ctgagcttcg atgttgacgg cttagacccg agctttacgc cagccaccgg cacgccggtc      780

gttggtggtt taacgtatcg cgaaggcctg tatatcacgg aggaaatcta taagacgggt      840

ttactgagcg gtctggacat tatggaggtt aatccaagct taggtaagac gccggaagaa      900

gttacccgta ccgttaacac ggcggtcgcg atcacgttag catgtttcgg tttagcccgc      960

gagggcaacc ataaaccaat tgattatctg aatccaccga agtga                     1005


<210>  3
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro 
            20                  25                  30          


Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val 
        35                  40                  45              


Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp 
    50                  55                  60                  


Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser 
65                  70                  75                  80  


Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu 
                85                  90                  95      


Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser 
            100                 105                 110         


Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly 
        115                 120                 125             


His Ala Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His 
    130                 135                 140                 


Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly 
145                 150                 155                 160 


Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp 
                165                 170                 175     


Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile 
            180                 185                 190         


Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu 
        195                 200                 205             


Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu 
    210                 215                 220                 


Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg 
225                 230                 235                 240 


Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro 
                245                 250                 255     


Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr 
            260                 265                 270         


Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu 
        275                 280                 285             


Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro 
    290                 295                 300                 


Glu Glu Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala 
305                 310                 315                 320 


Cys Phe Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu 
                325                 330                 335     


Asn Pro Pro Lys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Ser Gly Ser Gly Glu Phe Ser Ala Lys Ser Arg 
        355                 360                 365             


Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly 
    370                 375                 380                 


Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu 
385                 390                 395                 400 


Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro 
                405                 410                 415     


Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro 
            420                 425                 430         


Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu 
        435                 440                 445             


Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser 
    450                 455                 460                 


Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu 
465                 470                 475                 480 


Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr 
                485                 490                 495     


Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys 
            500                 505                 510         


Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr 
        515                 520                 525             


Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val 
    530                 535                 540                 


Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe 
545                 550                 555                 560 


Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu 
                565                 570                 575     


Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser 
            580                 585                 590         


Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr 
        595                 600                 605             


Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu 
    610                 615                 620                 


Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val 
625                 630                 635                 640 


Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn 
                645                 650                 655     


Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly 
            660                 665                 670         


Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Gly Ser Ser 
        675                 680                 685             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    690                 695                 700                 


Gly Gly Ala Ala Ala Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly 
705                 710                 715                 720 


Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro 
                725                 730                 735     


Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu 
            740                 745                 750         


Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn 
        755                 760                 765             


Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala 
    770                 775                 780                 


Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg 
785                 790                 795                 800 


Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile 
                805                 810                 815     


Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp 
            820                 825                 830         


Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu 
        835                 840                 845             


His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile 
    850                 855                 860                 


Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys 
865                 870                 875                 880 


Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr 
                885                 890                 895     


Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp 
            900                 905                 910         


Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu 
        915                 920                 925             


Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu 
    930                 935                 940                 


Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu 
945                 950                 955                 960 


Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly 
                965                 970                 975     


Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys 
            980                 985                 990         


Thr Pro Glu Glu Val Thr Arg Thr  Val Asn Thr Ala Val  Ala Ile Thr 
        995                 1000                 1005             


Leu Ala  Cys Phe Gly Leu Ala  Arg Glu Gly Asn His  Lys Pro Ile 
    1010                 1015                 1020             


Asp Tyr  Leu Asn Pro Pro Lys  
    1025                 1030 


<210>  4
<211>  3093
<212>  DNA
<213>  Homo sapiens

<400>  4
atgggttctt ctcaccatca tcaccaccac agctctggcg agaacctgta cttccagtct       60

gcgaagagcc gtacgatcgg cattattggt gcgccgttct ctaaaggtca gccacgcggt      120

ggtgtggaag agggtccgac ggttctgcgt aaggccggtt tattagaaaa gctgaaagag      180

caggagtgcg acgttaagga ctacggtgac ttaccattcg cggacatccc gaatgatagc      240

ccgttccaaa tcgttaagaa tccgcgctct gtgggtaaag caagcgagca gttagcaggt      300

aaggtggccg aggtcaagaa aaacggtcgt attagcctgg ttttaggcgg tgatcatagc      360

ttagcaattg gctctatctc tggtcatgcc cgtgtgcacc cagatttagg tgtcatttgg      420

gttgacgccc atacggatat caatacgcca ttaacgacca ccagcggcaa tctgcatggc      480

cagccggtta gcttcttact gaaggagctg aagggtaaaa ttccagatgt tccgggcttt      540

agctgggtca cgccatgtat ttctgccaag gatatcgtgt acattggctt acgtgacgtc      600

gacccaggtg agcactacat cttaaagacc ctgggtatca agtatttcag catgacggaa      660

gtggaccgct taggcatcgg caaggtgatg gaggagacgc tgagctatct gctgggccgt      720

aagaaacgtc caatccatct gagcttcgat gttgacggct tagacccgag ctttacgcca      780

gccaccggca cgccggtcgt tggtggttta acgtatcgcg aaggcctgta tatcacggag      840

gaaatctata agacgggttt actgagcggt ctggacatta tggaggttaa tccaagctta      900

ggtaagacgc cggaagaagt tacccgtacc gttaacacgg cggtcgcgat cacgttagca      960

tgtttcggtt tagcccgcga gggcaaccat aaaccaattg attatctgaa tccaccgaag     1020

ggcagcggca gcggctctgg ttctggtagc ggttctggct ctggcagcgg cagcggctct     1080

ggtgaattct ctgcgaagag ccgtacgatc ggcattattg gtgcgccgtt ctctaaaggt     1140

cagccacgcg gtggtgtgga agagggtccg acggttctgc gtaaggccgg tttattagaa     1200

aagctgaaag agcaggagtg cgacgttaag gactacggtg acttaccatt cgcggacatc     1260

ccgaatgata gcccgttcca aatcgttaag aatccgcgct ctgtgggtaa agcaagcgag     1320

cagttagcag gtaaggtggc cgaggtcaag aaaaacggtc gtattagcct ggttttaggc     1380

ggtgatcata gcttagcaat tggctctatc tctggtcatg cccgtgtgca cccagattta     1440

ggtgtcattt gggttgacgc ccatacggat atcaatacgc cattaacgac caccagcggc     1500

aatctgcatg gccagccggt tagcttctta ctgaaggagc tgaagggtaa aattccagat     1560

gttccgggct ttagctgggt cacgccatgt atttctgcca aggatatcgt gtacattggc     1620

ttacgtgacg tcgacccagg tgagcactac atcttaaaga ccctgggtat caagtatttc     1680

agcatgacgg aagtggaccg cttaggcatc ggcaaggtga tggaggagac gctgagctat     1740

ctgctgggcc gtaagaaacg tccaatccat ctgagcttcg atgttgacgg cttagacccg     1800

agctttacgc cagccaccgg cacgccggtc gttggtggtt taacgtatcg cgaaggcctg     1860

tatatcacgg aggaaatcta taagacgggt ttactgagcg gtctggacat tatggaggtt     1920

aatccaagct taggtaagac gccggaagaa gttacccgta ccgttaacac ggcggtcgcg     1980

atcacgttag catgtttcgg tttagcccgc gagggcaacc ataaaccaat tgattatctg     2040

aatccaccga agggcggcag ctctggcggt tcttctggtg gtagcagcgg cggtagctct     2100

ggcggctcta gcggtggtgc ggccgcatct gcgaagagcc gtacgatcgg cattattggt     2160

gcgccgttct ctaaaggtca gccacgcggt ggtgtggaag agggtccgac ggttctgcgt     2220

aaggccggtt tattagaaaa gctgaaagag caggagtgcg acgttaagga ctacggtgac     2280

ttaccattcg cggacatccc gaatgatagc ccgttccaaa tcgttaagaa tccgcgctct     2340

gtgggtaaag caagcgagca gttagcaggt aaggtggccg aggtcaagaa aaacggtcgt     2400

attagcctgg ttttaggcgg tgatcatagc ttagcaattg gctctatctc tggtcatgcc     2460

cgtgtgcacc cagatttagg tgtcatttgg gttgacgccc atacggatat caatacgcca     2520

ttaacgacca ccagcggcaa tctgcatggc cagccggtta gcttcttact gaaggagctg     2580

aagggtaaaa ttccagatgt tccgggcttt agctgggtca cgccatgtat ttctgccaag     2640

gatatcgtgt acattggctt acgtgacgtc gacccaggtg agcactacat cttaaagacc     2700

ctgggtatca agtatttcag catgacggaa gtggaccgct taggcatcgg caaggtgatg     2760

gaggagacgc tgagctatct gctgggccgt aagaaacgtc caatccatct gagcttcgat     2820

gttgacggct tagacccgag ctttacgcca gccaccggca cgccggtcgt tggtggttta     2880

acgtatcgcg aaggcctgta tatcacggag gaaatctata agacgggttt actgagcggt     2940

ctggacatta tggaggttaa tccaagctta ggtaagacgc cggaagaagt tacccgtacc     3000

gttaacacgg cggtcgcgat cacgttagca tgtttcggtt tagcccgcga gggcaaccat     3060

aaaccaattg attatctgaa tccaccgaag tga                                  3093


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Ser 
            20  


