                         SEQUENCE LISTING

<110>  Rigshospitalet
       Kbenhavns Universitet
       Syddansk Universitet
 
<120>  INHIBITORS OF COMPLEMENT ACTIVATION

<130>  17952PCT00

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Lys Asn Glu Ile Asp 
        355                 360                 365             


Leu Glu Ser Glu Leu Lys Ser Glu Gln Val Thr Glu 
    370                 375                 380 


<210>  2
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaggtggc tgcttctcta ttatgctctg tgcttctccc tgtcaaaggc ttcagcccac       60

accgtggagc taaacaatat gtttggccag atccagtcgc ctggttatcc agactcctat      120

cccagtgatt cagaggtgac ttggaatatc actgtcccag atgggtttcg gatcaagctt      180

tacttcatgc acttcaactt ggaatcctcc tacctttgtg aatatgacta tgtgaaggta      240

gaaactgagg accaggtgct ggcaaccttc tgtggcaggg agaccacaga cacagagcag      300

actcccggcc aggaggtggt cctctcccct ggctccttca tgtccatcac tttccggtca      360

gatttctcca atgaggagcg tttcacaggc tttgatgccc actacatggc tgtggatgtg      420

gacgagtgca aggagaggga ggacgaggag ctgtcctgtg accactactg ccacaactac      480

attggcggct actactgctc ctgccgcttc ggctacatcc tccacacaga caacaggacc      540

tgccgagtgg agtgcagtga caacctcttc actcaaagga ctggggtgat caccagccct      600

gacttcccaa acccttaccc caagagctct gaatgcctgt ataccatcga gctggaggag      660

ggtttcatgg tcaacctgca gtttgaggac atatttgaca ttgaggacca tcctgaggtg      720

ccctgcccct atgactacat caagatcaaa gttggtccaa aagttttggg gcctttctgt      780

ggagagaaag ccccagaacc catcagcacc cagagccaca gtgtcctgat cctgttccat      840

agtgacaact cgggagagaa ccggggctgg aggctctcat acagggctgc aggaaatgag      900

tgcccagagc tacagcctcc tgtccatggg aaaatcgagc cctcccaagc caagtatttc      960

ttcaaagacc aagtgctcgt cagctgtgac acaggctaca aagtgctgaa ggataatgtg     1020

gagatggaca cattccagat tgagtgtctg aaggatggga cgtggagtaa caagattccc     1080

acctgtaaaa aaaatgaaat cgatctggag agcgaactca agtcagagca agtgacagag     1140

tga                                                                   1143


<210>  3
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala 
    290                 295         


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Asn Glu Ile Asp Leu Glu Ser Glu Leu Lys Ser Glu Gln Val Thr 
1               5                   10                  15      


Glu 
    


<210>  5
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 
        435                 440                 445             


Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 
    450                 455                 460                 


Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 
                485                 490                 495     


Asp Pro Glu Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 
            500                 505                 510         


Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 
        515                 520                 525             


Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Gln Tyr 
    530                 535                 540                 


Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 
545                 550                 555                 560 


Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 
                565                 570                 575     


Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 
            580                 585                 590         


Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 
        595                 600                 605             


Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 
    610                 615                 620                 


Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 
625                 630                 635                 640 


Ala Cys Ala Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 
                645                 650                 655     


Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 
            660                 665                 670         


Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 
        675                 680                 685             


Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 
    690                 695                 


<210>  6
<211>  4353
<212>  DNA
<213>  Homo sapiens

<400>  6
gaagtcagcc acacaggata aaggagggaa gggaaggagc agatcttttc ggtaggaaga       60

cagattttgt tgtcaggttc ctgggagtgc aagagcaagt caaaggagag agagaggaga      120

gaggaaaagc cagagggaga gagggggaga ggggatctgt tgcaggcagg ggaaggcgtg      180

acctgaatgg agaatgccag ccaattccag agacacacag ggacctcaga acaaagataa      240

ggcatcacgg acaccacacc gggcacgagc tcacaggcaa gtcaagctgg gaggaccaag      300

gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc tattatgctc      360

tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat atgtttggcc      420

agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg acttggaata      480

tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac ttggaatcct      540

cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg ctggcaacct      600

tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg gtcctctccc      660

ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag cgtttcacag      720

gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg gaggacgagg      780

agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc tcctgccgct      840

tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt gacaacctct      900

tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac cccaagagct      960

ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg cagtttgagg     1020

acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac atcaagatca     1080

aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa cccatcagca     1140

cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag aaccggggct     1200

ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct cctgtccatg     1260

ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc gtcagctgtg     1320

acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag attgagtgtc     1380

tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac tgtagagccc     1440

caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc accacataca     1500

agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac aataacacag     1560

gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg agaagcctac     1620

ccacctgcct tccagtgtgt gggctcccca agttctcccg gaagctgatg gccaggatct     1680

tcaatggacg cccagcccag aaaggcacca ctccctggat tgccatgctg tcacacctga     1740

atgggcagcc cttctgcgga ggctcccttc taggctccag ctggatcgtg accgccgcac     1800

actgcctcca ccagtcactc gatccggaag atccgaccct acgtgattca gacttgctca     1860

gcccttctga cttcaaaatc atcctgggca agcattggag gctccggtca gatgaaaatg     1920

aacagcatct cggcgtcaaa cacaccactc tccaccccca gtatgatccc aacacattcg     1980

agaatgacgt ggctctggtg gagctgttgg agagcccagt gctgaatgcc ttcgtgatgc     2040

ccatctgtct gcctgaggga ccccagcagg aaggagccat ggtcatcgtc agcggctggg     2100

ggaagcagtt cttgcaaagg ttcccagaga ccctgatgga gattgaaatc ccgattgttg     2160

accacagcac ctgccagaag gcttatgccc cgctgaagaa gaaagtgacc agggacatga     2220

tctgtgctgg ggagaaggaa gggggaaagg acgcctgtgc gggtgactct ggaggcccca     2280

tggtgaccct gaatagagaa agaggccagt ggtacctggt gggcactgtg tcctggggtg     2340

atgactgtgg gaagaaggac cgctacggag tatactctta catccaccac aacaaggact     2400

ggatccagag ggtcaccgga gtgaggaact gaatttggct cctcagcccc agcaccacca     2460

gctgtgggca gtcagtagca gaggacgatc ctccgatgaa agcagccatt tctcctttcc     2520

ttcctcccat cccccctcct tcggcctatc cattactggg caatagagca ggtatcttca     2580

cccccttttc actctcttta aagagatgga gcaagagagt ggtcagaaca caggccgaat     2640

ccaggctcta tcacttacta gtttgcagtg ctgggcaggt gacttcatct cttcgaactt     2700

cagtttcttc ataagatgga aatgctatac cttacctacc tcgtaaaagt ctgatgagga     2760

aaagattaac taatagatgc atagcactta acagagtgca tagcatacac tgttttcaat     2820

aaatgcacct tagcagaagg tcgatgtgtc taccaggcag acgaagctct cttacaaacc     2880

cctgcctggg tcttagcatt gatcagtgac acacctctcc cctcaacctt gaccatctcc     2940

atctgccctt aaatgctgta tgcttttttg ccaccgtgca acttgcccaa catcaatctt     3000

caccctcatc cctaaaaaag taaaacagac aaggttctga gtcctgtggt atgtccccta     3060

gcaaatgtaa ctaggaacat gcactagatg acagattgcg ggagggcctg agagaagcag     3120

ggacaggagg gagcctgggg attgtggttt gggaaggcag acacctggtt ctagaactag     3180

ctctgccctt agccccctgt atgaccctat gcaagtcctc ctccctcatc tcaaagggtc     3240

ctcaaagctc tgacgatcta agatacaatg aagccatttt ccccctgata agatgaggta     3300

aagccaatgt aaccaaaagg caaaaattac aatcggttca aaggaacttt gatgcagaca     3360

aaatgctgct gctgctgctc ctgaaatacc cacccctttc cactacgggt gggttcccaa     3420

ggacatggga caggcaaagt gtgagccaaa ggatccttcc ttattcctaa gcagagcatc     3480

tgctctgggc cctggcctcc ttcccttctt gggaaactgg gctgcatgag gtgggccctg     3540

gtagtttgta ccccaggccc ctatactctt ccttcctatg tccacagctg accccaagca     3600

gccgttcccc gactcctcac ccctgagcct caccctgaac tccctcatct tgcaaggcca     3660

taagtgtttt ccaagcaaaa tgcctctccc atcctctctc aggaagcttc tagagacttt     3720

atgccctcca gagctccaag atataagccc tccaagggat cagaagctcc aagttcctgt     3780

cttctgtttt atagaaattg atcttccctg ggggacttta actcttgacc tgtatgcagc     3840

tgttggagta attccaggtc tcttgaaaaa aaagaggaag ataatggaga atgagaacat     3900

atatatatat atattaagcc ccaggctgaa tactcaggga cagcaattca cagcctgcct     3960

ctggttctat aaacaagtca ttctacctct ttgtgccctg ctgtttattc tgtaagggga     4020

aggtggcaat gggacccagc tccatcagac acttgtcaag ctagcagaaa ctccattttc     4080

aatgccaaag aagaactgta atgctgtttt ggaatcatcc caaggcatcc caagacacca     4140

tatcttccca tttcaagcac tgcctgggca caccccaaca tcccaggctg tggtggctcc     4200

tgtgggaact acctagatga agagagtatc atttatacct tctaggagct cctattggga     4260

gacatgaaac atatgtaatt gactaccatg taatagaaca aaccctgcca agtgctgctt     4320

tggaaagtca tggaggtaaa agaaagacca ttc                                  4353


<210>  7
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 
        435                 440                 445             


Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 
    450                 455                 460                 


Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 
465                 470                 475                 480 


Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala 
                485                 490                 495     


His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 
            500                 505                 510         


Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 
        515                 520                 525             


Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 
    530                 535                 540                 


Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 
545                 550                 555                 560 


Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 
                565                 570                 575     


Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly 
            580                 585                 590         


Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 
        595                 600                 605             


Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 
    610                 615                 620                 


Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 
625                 630                 635                 640 


Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 
                645                 650                 655     


Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp 
            660                 665                 670         


Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 
        675                 680                 685             


Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 
    690                 695                 700                 


Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser 
705                 710                 715                 720 


Val Val Glu Pro Gln Val Glu Arg 
                725             


<210>  8
<211>  4137
<212>  DNA
<213>  Homo sapiens

<400>  8
gaagtcagcc acacaggata aaggagggaa gggaaggagc agatcttttc ggtaggaaga       60

cagattttgt tgtcaggttc ctgggagtgc aagagcaagt caaaggagag agagaggaga      120

gaggaaaagc cagagggaga gagggggaga ggggatctgt tgcaggcagg ggaaggcgtg      180

acctgaatgg agaatgccag ccaattccag agacacacag ggacctcaga acaaagataa      240

ggcatcacgg acaccacacc gggcacgagc tcacaggcaa gtcaagctgg gaggaccaag      300

gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc tattatgctc      360

tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat atgtttggcc      420

agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg acttggaata      480

tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac ttggaatcct      540

cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg ctggcaacct      600

tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg gtcctctccc      660

ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag cgtttcacag      720

gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg gaggacgagg      780

agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc tcctgccgct      840

tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt gacaacctct      900

tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac cccaagagct      960

ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg cagtttgagg     1020

acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac atcaagatca     1080

aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa cccatcagca     1140

cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag aaccggggct     1200

ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct cctgtccatg     1260

ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc gtcagctgtg     1320

acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag attgagtgtc     1380

tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac tgtagagccc     1440

caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc accacataca     1500

agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac aataacacag     1560

gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg agaagcctac     1620

ccacctgcct tccagagtgt ggtcagccct cccgctccct gccaagcctg gtcaagagga     1680

tcattggggg ccgaaatgct gagcctggcc tcttcccgtg gcaggccctg atagtggtgg     1740

aggacacttc gagagtgcca aatgacaagt ggtttgggag tggggccctg ctctctgcgt     1800

cctggatcct cacagcagct catgtgctgc gctcccagcg tagagacacc acggtgatac     1860

cagtctccaa ggagcatgtc accgtctacc tgggcttgca tgatgtgcga gacaaatcgg     1920

gggcagtcaa cagctcagct gcccgagtgg tgctccaccc agacttcaac atccaaaact     1980

acaaccacga tatagctctg gtgcagctgc aggagcctgt gcccctggga ccccacgtta     2040

tgcctgtctg cctgccaagg cttgagcctg aaggcccggc cccccacatg ctgggcctgg     2100

tggccggctg gggcatctcc aatcccaatg tgacagtgga tgagatcatc agcagtggca     2160

cacggacctt gtcagatgtc ctgcagtatg tcaagttacc cgtggtgcct cacgctgagt     2220

gcaaaactag ctatgagtcc cgctcgggca attacagcgt cacggagaac atgttctgtg     2280

ctggctacta cgagggcggc aaagacacgt gccttggaga tagcggtggg gcctttgtca     2340

tctttgatga cttgagccag cgctgggtgg tgcaaggcct ggtgtcctgg gggggacctg     2400

aagaatgcgg cagcaagcag gtctatggag tctacacaaa ggtctccaat tacgtggact     2460

gggtgtggga gcagatgggc ttaccacaaa gtgttgtgga gccccaggtg gaacggtgag     2520

ctgacttact tcctcggggc ctgcctcccc tgagcgaagc tacaccgcac ttccgacagc     2580

acactccaca ttacttatca gaccatatgg aatggaacac actgacctag cggtggcttc     2640

tcctaccgag acagccccca ggaccctgag aggcagagtg tggtataggg aaaaggctcc     2700

aggcaggaga cctgtgttcc tgagcttgtc caagtctctt tccctgtctg ggcctcactc     2760

taccgagtaa tacaatgcag gagctcaacc aaggcctctg tgccaatccc agcactcctt     2820

tccaggccat gcttcttacc ccagtggcct ttattcactc ctgaccactt atcaaaccca     2880

tcggtcctac tgttggtata actgagcttg gacctgacta ttagaaaatg gtttctaaca     2940

ttgaactgaa tgccgcatct gtatattttc ctgctctgcc ttctgggact agccttggcc     3000

taatccttcc tctaggagaa gagcattcag gttttgggag atggctcata gccaagcccc     3060

tctctcttag tgtgatccct tggagcacct tcatgcctgg ggtttctctc ccaaaagctt     3120

cttgcagtct aagccttatc ccttatgttc cccattaaag gaatttcaaa agacatggag     3180

aaagttggga aggtttgtgc tgactgctgg gagcagaata gccgtgggag gcccaccaag     3240

cccttaaatt cccattgtca actcagaaca catttgggcc catatgccac cctggaacac     3300

cagctgacac catgggcgtc cacacctgct gctccagaca agcacaaagc aatctttcag     3360

ccttgaaatg tattatctga aaggctacct gaagcccagg cccgaatatg gggacttagt     3420

cgattacctg gaaaaagaaa agacccacac tgtgtcctgc tgtgcttttg ggcaggaaaa     3480

tggaagaaag agtggggtgg gcacattaga agtcacccaa atcctgccag gctgcctggc     3540

atccctgggg catgagctgg gcggagaatc caccccgcag gatgttcaga gggacccact     3600

ccttcatttt tcagagtcaa aggaatcaga ggctcaccca tggcaggcag tgaaaagagc     3660

caggagtcct gggttctagt ccctgctctg cccccaactg gctgtataac ctttgaaaaa     3720

tcattttctt tgtctgagtc tctggttctc cgtcagcaac aggctggcat aaggtcccct     3780

gcaggttcct tctagctgga gcactcagag cttccctgac tgctagcagc ctctctggcc     3840

ctcacagggc tgattgttct ccttctccct ggagctctct ctcctgaaaa tctccatcag     3900

agcaaggcag ccagagaagc ccctgagagg gaatgattgg gaagtgtcca ctttctcaac     3960

cggctcatca aacacactcc tttgtctatg aatggcacat gtaaatgatg ttatattttg     4020

tatcttttat atcatatgct tcaccattct gtaaagggcc tctgcattgt tgctcccatc     4080

aggggtctca agtggaaata aaccctcgtg gataaccaaa aaaaaaaaaa aaaaaaa        4137


<210>  9
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  10
<211>  2460
<212>  DNA
<213>  Homo sapiens

<400>  10
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg       60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc      120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc      180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag      240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag      300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg      360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc      420

tatgcagccg aggacattga cgagtgccag gtggccccgg gagaggcgcc cacctgcgac      480

caccactgcc acaaccacct gggcggtttc tactgctcct gccgcgcagg ctacgtcctg      540

caccgtaaca agcgcacctg ctcagccctg tgctccggcc aggtcttcac ccagaggtct      600

ggggagctca gcagccctga atacccacgg ccgtatccca aactctccag ttgcacttac      660

agcatcagcc tggaggaggg gttcagtgtc attctggact ttgtggagtc cttcgatgtg      720

gagacacacc ctgaaaccct gtgtccctac gactttctca agattcaaac agacagagaa      780

gaacatggcc cattctgtgg gaagacattg ccccacagga ttgaaacaaa aagcaacacg      840

gtgaccatca cctttgtcac agatgaatca ggagaccaca caggctggaa gatccactac      900

acgagcacag cgcagccttg cccttatccg atggcgccac ctaatggcca cgtttcacct      960

gtgcaagcca aatacatcct gaaagacagc ttctccatct tttgcgagac tggctatgag     1020

cttctgcaag gtcacttgcc cctgaaatcc tttactgcag tttgtcagaa agatggatct     1080

tgggaccggc caatgcccgc gtgcagcatt gttgactgtg gccctcctga tgatctaccc     1140

agtggccgag tggagtacat cacaggtcct ggagtgacca cctacaaagc tgtgattcag     1200

tacagctgtg aagagacctt ctacacaatg aaagtgaatg atggtaaata tgtgtgtgag     1260

gctgatggat tctggacgag ctccaaagga gaaaaatcac tcccagtctg tgagcctgtt     1320

tgtggactat cagcccgcac aacaggaggg cgtatatatg gagggcaaaa ggcaaaacct     1380

ggtgattttc cttggcaagt cctgatatta ggtggaacca cagcagcagg tgcactttta     1440

tatgacaact gggtcctaac agctgctcat gccgtctatg agcaaaaaca tgatgcatcc     1500

gccctggaca ttcgaatggg caccctgaaa agactatcac ctcattatac acaagcctgg     1560

tctgaagctg tttttataca tgaaggttat actcatgatg ctggctttga caatgacata     1620

gcactgatta aattgaataa caaagttgta atcaatagca acatcacgcc tatttgtctg     1680

ccaagaaaag aagctgaatc ctttatgagg acagatgaca ttggaactgc atctggatgg     1740

ggattaaccc aaaggggttt tcttgctaga aatctaatgt atgtcgacat accgattgtt     1800

gaccatcaaa aatgtactgc tgcatatgaa aagccaccct atccaagggg aagtgtaact     1860

gctaacatgc tttgtgctgg cttagaaagt gggggcaagg acagctgcag aggtgacagc     1920

ggaggggcac tggtgtttct agatagtgaa acagagaggt ggtttgtggg aggaatagtg     1980

tcctggggtt ccatgaattg tggggaagca ggtcagtatg gagtctacac aaaagttatt     2040

aactatattc cctggatcga gaacataatt agtgattttt aacttgcgtg tctgcagtca     2100

aggattcttc atttttagaa atgcctgtga agaccttggc agcgacgtgg ctcgagaagc     2160

attcatcatt actgtggaca tggcagttgt tgctccaccc aaaaaaacag actccaggtg     2220

aggctgctgt catttctcca cttgccagtt taattccagc cttacccatt gactcaaggg     2280

gacataaacc acgagagtga cagtcatctt tgcccaccca gtgtaatgtc actgctcaaa     2340

ttacatttca ttaccttaaa aagccagtct cttttcatac tggctgttgg catttctgta     2400

aactgcctgt ccatgctctt tgtttttaaa cttgttctta ttgaaaaaaa aaaaaaaaaa     2460


<210>  11
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185 


<210>  12
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  12
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg       60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc      120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc      180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag      240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag      300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg      360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc      420

tatgcagccg aggacattga cgagtgccag gtggccccgg gagaggcgcc cacctgcgac      480

caccactgcc acaaccacct gggcggtttc tactgctcct gccgcgcagg ctacgtcctg      540

caccgtaaca agcgcacctg ctcagagcag agcctctagc ctcccctgga gctccggcct      600

gcccagcagg tcagaagcca gagccagcct gctggcctca gctccgggtt gggctgagat      660

ggctgtgccc caactcccat tcacccacca tggacccaat aataaacctg gccccacccc      720

aaaaaaaaaa aaaaaaaa                                                    738


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA primer

<400>  13
gcacccagag ccacagtg                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  14
gccttccagt gtgtgggc                                                     18


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  15
gccttccaga gtgtggtca                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  16
cgatctggag agcgaactc                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  17
ctgttcttca cactggctg                                                    19


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  18
ctgctgagat catgttgttc                                                   20


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  19
ttatacgact cacta                                                        15


