                         SEQUENCE LISTING

<110>  Protagen Aktiengesellschaft/Universittsklinikum Regensburg
 
<120>  Markersequenzen fr Obesity

<130>  PRO85WO_2009/03

<160>  26    

<170>  PatentIn version 3.3

<210>  1
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ala Ala Glu Glu Glu Glu Val Asp Ser Ala Asp Thr Gly Glu Arg 
1               5                   10                  15      


Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Ile 
            20                  25                  30          


Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val Pro Cys 
        35                  40                  45              


Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Lys Ile Trp 
    50                  55                  60                  


Thr Leu Lys Phe Ser His Asn Ile Ser Asn Lys Thr Pro Leu Val Leu 
65                  70                  75                  80  


Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                  90                  95      


Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                 105                 110         


Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu Val Glu 
        115                 120                 125             


Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                 135                 140                 


Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                 150                 155                 160 


Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Asn His Leu Ile Leu Val 
                165                 170                 175     


Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Asp Arg 
            180                 185                 190         


Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                 200                 205             


Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                 215                 220                 


Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                 230                 235                 240 


Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                 250                 255     


Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                 265                 270         


Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Lys Met His Pro Asp Ile 
        275                 280                 285             


Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                 295                 300                 


Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                 310                 315                 320 


Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Glu 
                325                 330                 335     


Phe Asn Gln Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                 345                 


<210>  2
<211>  1076
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Glu Pro Gly Ser Lys Ser Val Ser Arg Ser Asp Trp Gln Pro Glu 
1               5                   10                  15      


Pro His Gln Arg Pro Ile Thr Pro Leu Glu Pro Gly Pro Glu Lys Thr 
            20                  25                  30          


Pro Ile Ala Gln Pro Glu Ser Lys Thr Leu Gln Gly Ser Asn Thr Gln 
        35                  40                  45              


Gln Lys Pro Ala Ser Asn Gln Arg Pro Leu Thr Gln Gln Glu Thr Pro 
    50                  55                  60                  


Ala Gln His Asp Ala Glu Ser Gln Lys Glu Pro Arg Ala Gln Gln Lys 
65                  70                  75                  80  


Ser Ala Ser Gln Glu Glu Phe Leu Ala Pro Gln Lys Pro Ala Pro Gln 
                85                  90                  95      


Gln Ser Pro Tyr Ile Gln Arg Val Leu Leu Thr Gln Gln Glu Ala Ala 
            100                 105                 110         


Ser Gln Gln Gly Pro Gly Leu Gly Lys Glu Ser Ile Thr Gln Gln Glu 
        115                 120                 125             


Pro Ala Leu Arg Gln Arg His Val Ala Gln Pro Gly Pro Gly Pro Gly 
    130                 135                 140                 


Glu Pro Pro Pro Ala Gln Gln Glu Ala Glu Ser Thr Pro Ala Ala Gln 
145                 150                 155                 160 


Ala Lys Pro Gly Ala Lys Arg Glu Pro Ser Ala Pro Thr Glu Ser Thr 
                165                 170                 175     


Ser Gln Glu Thr Pro Glu Gln Ser Asp Lys Gln Thr Thr Pro Val Gln 
            180                 185                 190         


Gly Ala Lys Ser Lys Gln Gly Ser Leu Thr Glu Leu Gly Phe Leu Thr 
        195                 200                 205             


Lys Leu Gln Glu Leu Ser Ile Gln Arg Ser Ala Leu Glu Trp Lys Ala 
    210                 215                 220                 


Leu Ser Glu Trp Val Thr Asp Ser Glu Ser Glu Ser Asp Val Gly Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Asp Ser Pro Ala Thr Met Gly Gly Met Val Ala Gln 
                245                 250                 255     


Gly Val Lys Leu Gly Phe Lys Gly Lys Ser Gly Tyr Lys Val Met Ser 
            260                 265                 270         


Gly Tyr Ser Gly Thr Ser Pro His Glu Lys Thr Ser Ala Arg Asn His 
        275                 280                 285             


Arg His Tyr Gln Asp Thr Ala Ser Arg Leu Ile His Asn Met Asp Leu 
    290                 295                 300                 


Arg Thr Met Thr Gln Ser Leu Val Thr Leu Ala Glu Asp Asn Ile Ala 
305                 310                 315                 320 


Phe Phe Ser Ser Gln Gly Pro Gly Glu Thr Ala Gln Arg Leu Ser Gly 
                325                 330                 335     


Val Phe Ala Gly Val Arg Glu Gln Ala Leu Gly Leu Glu Pro Ala Leu 
            340                 345                 350         


Gly Arg Leu Leu Gly Val Ala His Leu Phe Asp Leu Asp Pro Glu Thr 
        355                 360                 365             


Pro Ala Asn Gly Tyr Arg Ser Leu Val His Thr Ala Arg Cys Cys Leu 
    370                 375                 380                 


Ala His Leu Leu His Lys Ser Arg Tyr Val Ala Ser Asn Arg Arg Ser 
385                 390                 395                 400 


Ile Phe Phe Arg Thr Ser His Asn Leu Ala Glu Leu Glu Ala Tyr Leu 
                405                 410                 415     


Ala Ala Leu Thr Gln Leu Arg Ala Leu Val Tyr Tyr Ala Gln Arg Leu 
            420                 425                 430         


Leu Val Thr Asn Arg Pro Gly Val Leu Phe Phe Glu Gly Asp Glu Gly 
        435                 440                 445             


Leu Thr Ala Asp Phe Leu Arg Glu Tyr Val Thr Leu His Lys Gly Cys 
    450                 455                 460                 


Phe Tyr Gly Arg Cys Leu Gly Phe Gln Phe Thr Pro Ala Ile Arg Pro 
465                 470                 475                 480 


Phe Leu Gln Thr Ile Ser Ile Gly Leu Val Ser Phe Gly Glu His Tyr 
                485                 490                 495     


Lys Arg Asn Glu Thr Gly Leu Ser Val Ala Ala Ser Ser Leu Phe Thr 
            500                 505                 510         


Ser Gly Arg Phe Ala Ile Asp Pro Glu Leu Arg Gly Ala Glu Phe Glu 
        515                 520                 525             


Arg Ile Thr Gln Asn Leu Asp Val His Phe Trp Lys Ala Phe Trp Asn 
    530                 535                 540                 


Ile Thr Glu Met Glu Val Leu Ser Ser Leu Ala Asn Met Ala Ser Ala 
545                 550                 555                 560 


Thr Val Arg Val Ser Arg Leu Leu Ser Leu Pro Pro Glu Ala Phe Glu 
                565                 570                 575     


Met Pro Leu Thr Ala Asp Pro Thr Leu Thr Val Thr Ile Ser Pro Pro 
            580                 585                 590         


Leu Ala His Thr Gly Pro Gly Pro Val Leu Val Arg Leu Ile Ser Tyr 
        595                 600                 605             


Asp Leu Arg Glu Gly Gln Asp Ser Glu Glu Leu Ser Ser Leu Ile Lys 
    610                 615                 620                 


Ser Asn Gly Gln Arg Ser Leu Glu Leu Trp Pro Arg Pro Gln Gln Ala 
625                 630                 635                 640 


Pro Arg Ser Arg Ser Leu Ile Val His Phe His Gly Gly Gly Phe Val 
                645                 650                 655     


Ala Gln Thr Ser Arg Ser His Glu Pro Tyr Leu Lys Ser Trp Ala Gln 
            660                 665                 670         


Glu Leu Gly Ala Pro Ile Ile Ser Ile Asp Tyr Ser Leu Ala Pro Glu 
        675                 680                 685             


Ala Pro Phe Pro Arg Ala Leu Glu Glu Cys Phe Phe Ala Tyr Cys Trp 
    690                 695                 700                 


Ala Ile Lys His Cys Ala Leu Leu Gly Ser Thr Gly Glu Arg Ile Cys 
705                 710                 715                 720 


Leu Ala Gly Asp Ser Ala Gly Gly Asn Leu Cys Phe Thr Val Ala Leu 
                725                 730                 735     


Arg Ala Ala Ala Tyr Gly Val Arg Val Pro Asp Gly Ile Met Ala Ala 
            740                 745                 750         


Tyr Pro Ala Thr Met Leu Gln Pro Ala Ala Ser Pro Ser Arg Leu Leu 
        755                 760                 765             


Ser Leu Met Asp Pro Leu Leu Pro Leu Ser Val Leu Ser Lys Cys Val 
    770                 775                 780                 


Ser Ala Tyr Ala Gly Ala Lys Thr Glu Asp His Ser Asn Ser Asp Gln 
785                 790                 795                 800 


Lys Ala Leu Gly Met Met Gly Leu Val Arg Arg Asp Thr Ala Leu Leu 
                805                 810                 815     


Leu Arg Asp Phe Arg Leu Gly Ala Ser Ser Trp Leu Asn Ser Phe Leu 
            820                 825                 830         


Glu Leu Ser Gly Arg Lys Ser Gln Lys Met Ser Glu Pro Ile Ala Glu 
        835                 840                 845             


Pro Met Arg Arg Ser Val Ser Glu Ala Ala Leu Ala Gln Pro Gln Gly 
    850                 855                 860                 


Pro Leu Gly Thr Asp Ser Leu Lys Asn Leu Thr Leu Arg Asp Leu Ser 
865                 870                 875                 880 


Leu Arg Gly Asn Ser Glu Thr Ser Ser Asp Thr Pro Glu Met Ser Leu 
                885                 890                 895     


Ser Ala Glu Thr Leu Ser Pro Ser Thr Pro Ser Asp Val Asn Phe Leu 
            900                 905                 910         


Leu Pro Pro Glu Asp Ala Gly Glu Glu Ala Glu Ala Lys Asn Glu Leu 
        915                 920                 925             


Ser Pro Met Asp Arg Gly Leu Gly Val Arg Ala Ala Phe Pro Glu Gly 
    930                 935                 940                 


Phe His Pro Arg Arg Ser Ser Gln Gly Ala Thr Gln Met Pro Leu Tyr 
945                 950                 955                 960 


Ser Ser Pro Ile Val Lys Asn Pro Phe Met Ser Pro Leu Leu Ala Pro 
                965                 970                 975     


Asp Ser Met Leu Lys Ser Leu Pro Pro Val His Ile Val Ala Cys Ala 
            980                 985                 990         


Leu Asp Pro Met Leu Asp Asp Ser  Val Met Leu Ala Arg  Arg Leu Arg 
        995                 1000                 1005             


Asn Leu  Gly Gln Pro Val Thr  Leu Arg Val Val Glu  Asp Leu Pro 
    1010                 1015                 1020             


His Gly  Phe Leu Thr Leu Ala  Ala Leu Cys Arg Glu  Thr Arg Gln 
    1025                 1030                 1035             


Ala Ala  Glu Leu Cys Val Glu  Arg Ile Arg Leu Val  Leu Thr Pro 
    1040                 1045                 1050             


Pro Ala  Gly Ala Gly Pro Ser  Gly Glu Thr Gly Ala  Ala Gly Val 
    1055                 1060                 1065             


Asp Gly  Gly Cys Gly Gly Arg  His 
    1070                 1075     


<210>  3
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  3

Glu Asn Thr Asp Pro Ala Ser Glu Arg Gly Asn Ala Ser Ser Ser Gln 
1               5                   10                  15      


Lys Glu Lys Val Leu Pro Glu Ala Gly Ala Gly Glu Asp Ser Pro Gly 
            20                  25                  30          


Arg Asn Met Asp Thr Ala Leu Glu Glu Leu Gln Leu Pro Pro Asn Ala 
        35                  40                  45              


Glu Gly His Val Lys Gln Val Ser Pro Arg Arg Pro Gln Ala Thr Glu 
    50                  55                  60                  


Ala Val Gly Arg Pro Thr Gly Pro Ala Gly Leu Arg Arg Thr Pro Asn 
65                  70                  75                  80  


Lys Gln Pro Ser Asp His Ser Tyr Ala Leu Leu Asp Leu Asp Ser Leu 
                85                  90                  95      


Lys Lys Lys Leu Phe Leu Thr Leu Lys Glu Asn Glu Lys Leu Arg Lys 
            100                 105                 110         


Arg Leu Gln Ala Gln Arg Leu Val Met Arg Arg Met Ser Ser Arg Leu 
        115                 120                 125             


Arg Ala Cys Lys Gly His Arg Gly Leu Gln Ala Arg Leu Gly Pro Glu 
    130                 135                 140                 


Gln Gln Ser 
145         


<210>  4
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
1               5                   10                  15      


Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
            20                  25                  30          


Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
        35                  40                  45              


Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
    50                  55                  60                  


Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
65                  70                  75                  80  


Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                85                  90                  95      


Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
            100                 105                 110         


Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
        115                 120                 125             


Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
    130                 135                 140                 


Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
145                 150                 155                 160 


Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                165                 170                 175     


Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
            180                 185                 190         


Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
        195                 200                 205             


Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
    210                 215                 220                 


Asp Ala Arg Ser Tyr Asn Arg Phe Gln Ile Ala Thr Val Thr Glu Lys 
225                 230                 235                 240 


Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                245                 250                 255     


Ala His Met Ile Ser Gly Phe Glu 
            260                 


<210>  5
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Ala Met Leu Arg Val Gln Pro Glu Ala Gln Ala Lys Val Asp Val 
1               5                   10                  15      


Phe Arg Glu Asp Leu Cys Thr Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
            20                  25                  30          


Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
        35                  40                  45              


Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
    50                  55                  60                  


Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
65                  70                  75                  80  


Gln Glu Lys Glu Asp Lys Asp Glu Lys Lys Lys Gly Glu Asp Glu Asp 
                85                  90                  95      


Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
            100                 105                 110         


Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
        115                 120                 125             


Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
    130                 135                 140                 


Gly Asn Asn Phe Gly Val Ala Val Gln Glu Lys Val Phe Glu Leu Met 
145                 150                 155                 160 


Thr Ser Leu His Thr Lys Leu Glu Gly Phe His Thr Gln Ile Ser Lys 
                165                 170                 175     


Tyr Phe Ser Glu Arg Gly Asp Ala Val Thr Lys Ala Ala Lys Gln Pro 
            180                 185                 190         


His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
        195                 200                 205             


Tyr Arg Asp Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
    210                 215                 220                 


Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
225                 230                 235                 240 


Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                245                 


<210>  6
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Gly Leu Thr Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln Ser Leu Arg Asn Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Gln Gly Thr Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210>  7
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Ala Pro Lys Gln Asp Pro Lys Pro Lys Phe Gln Glu Gly Glu Arg 
1               5                   10                  15      


Val Leu Cys Phe His Gly Pro Leu Leu Tyr Glu Ala Lys Cys Val Lys 
            20                  25                  30          


Val Ala Ile Lys Asp Lys Gln Val Lys Tyr Phe Ile His Tyr Ser Gly 
        35                  40                  45              


Trp Asn Lys Asn Trp Asp Glu Trp Val Pro Glu Ser Arg Val Leu Lys 
    50                  55                  60                  


Tyr Val Asp Thr Asn Leu Gln Lys Gln Arg Glu Leu Gln Lys Ala Asn 
65                  70                  75                  80  


Gln Glu Gln Tyr Ala Glu Gly Lys Met Arg Gly Ala Ala Pro Gly Lys 
                85                  90                  95      


Lys Thr Ser Gly Leu Gln Gln Lys Asn Val Glu Val Lys Thr Lys Lys 
            100                 105                 110         


Asn Lys Gln Lys Thr Pro Gly Asn Gly Asp Gly Gly Ser Thr Ser Glu 
        115                 120                 125             


Thr Pro Gln Pro Pro Arg Lys Lys Arg Ala Arg Val Asp Pro Thr Val 
    130                 135                 140                 


Glu Asn Glu Glu Thr Phe Met Asn Arg Val Glu Val Lys Val Lys Ile 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Pro Trp Leu Val Asp Asp Trp Asp Leu Ile Thr 
                165                 170                 175     


Arg Gln Lys Gln Leu Phe Tyr Leu Pro Ala Lys Lys Asn Val Asp Ser 
            180                 185                 190         


Ile Leu Glu Asp Tyr Ala Asn Tyr Lys Lys Ser Arg Gly Asn Thr Asp 
        195                 200                 205             


Asn Lys Glu Tyr Ala Val Asn Glu Val Val Ala Gly Ile Lys Glu Tyr 
    210                 215                 220                 


Phe Asn Val Met Leu Gly Thr Gln Leu Leu Tyr Lys Phe Glu Arg Pro 
225                 230                 235                 240 


Gln Tyr Ala Glu Ile Leu Ala Asp His Pro Asp Ala Pro Met Ser Gln 
                245                 250                 255     


Val Tyr Gly Ala Pro His Leu Leu Arg Leu Phe Val Arg Ile Gly Ala 
            260                 265                 270         


Met Leu Ala Tyr Thr Pro Leu Asp Glu Lys Ser Leu Ala Leu Leu Leu 
        275                 280                 285             


Asn Tyr Leu His Asp Phe Leu Lys Tyr Leu Ala Lys Asn Ser Ala Thr 
    290                 295                 300                 


Leu Phe Ser Ala Ser Asp Tyr Glu Val Ala Pro Pro Glu Tyr His Arg 
305                 310                 315                 320 


Lys Ala Val 
            


<210>  8
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Cys Pro Gly Asn Trp Leu Trp Ala Ser Met Thr Phe Met Ala Arg 
1               5                   10                  15      


Phe Ser Arg Ser Ser Ser Arg Ser Pro Val Arg Thr Arg Gly Thr Leu 
            20                  25                  30          


Glu Glu Met Pro Thr Val Gln His Pro Phe Leu Asn Val Phe Glu Leu 
        35                  40                  45              


Glu Arg Leu Leu Tyr Thr Gly Lys Thr Ala Cys Asn His Ala Asp Glu 
    50                  55                  60                  


Val Trp Pro Gly Leu Tyr Leu Gly Asp Gln Asp Met Ala Asn Asn Arg 
65                  70                  75                  80  


Arg Glu Leu Arg Arg Leu Gly Ile Thr His Val Leu Asn Ala Ser His 
                85                  90                  95      


Ser Arg Trp Arg Gly Thr Pro Glu Ala Tyr Glu Gly Leu Gly Ile Arg 
            100                 105                 110         


Tyr Leu Gly Val Glu Ala His Asp Ser Pro Ala Phe Asp Met Ser Ile 
        115                 120                 125             


His Phe Gln Thr Ala Ala Asp Phe Ile His Arg Ala Leu Ser Gln Pro 
    130                 135                 140                 


Gly Gly Lys Ile Leu Val His Cys Ala Val Gly Val Ser Arg Ser Ala 
145                 150                 155                 160 


Thr Leu Val Leu Ala Tyr Leu Met Leu Tyr His His Leu Thr Leu Val 
                165                 170                 175     


Glu Ala Ile Lys Lys Val Lys Asp His Arg Gly Ile Ile Pro Asn Arg 
            180                 185                 190         


Gly Phe Leu Arg Gln Leu Leu Ala Leu Asp Arg Arg Leu Arg Gln Gly 
        195                 200                 205             


Leu Glu Ala 
    210     


<210>  9
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
1               5                   10                  15      


Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
            20                  25                  30          


Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
        35                  40                  45              


Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
    50                  55                  60                  


Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
65                  70                  75                  80  


Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                85                  90                  95      


Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
            100                 105                 110         


Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
        115                 120                 125             


Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
    130                 135                 140                 


Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
145                 150                 155                 160 


Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                165                 170                 175     


Ala Gly Glu Glu 
            180 


<210>  10
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Ser Gly Asp Tyr Glu Asp Asp Leu Cys Arg Arg Ala Leu Ile Leu 
1               5                   10                  15      


Val Ser Asp Leu Cys Ala Arg Val Arg Asp Ala Asp Thr Asn Asp Arg 
            20                  25                  30          


Cys Gln Glu Phe Asn Asp Arg Ile Arg Gly Tyr Pro Arg Gly Pro Asp 
        35                  40                  45              


Ala Asp Ile Ser Val Ser Leu Leu Ser Val Ile Val Thr Phe Cys Gly 
    50                  55                  60                  


Ile Val Leu Leu Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp 
65                  70                  75                  80  


Val His Trp Arg Asp Lys Gly Gly Ser Ala Val Gly Gly Gly Pro Leu 
                85                  90                  95      


Arg Lys Asp Leu Gly Pro Gly Val Gly Leu Ala Gly Leu Val Gly Gly 
            100                 105                 110         


Gly Gly His His Leu Ala Ala Gly Leu Gly Gly His Pro Leu Leu Gly 
        115                 120                 125             


Gly Pro His His His Ala His Ala Ala His His Pro Pro Phe Ala Glu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Ser Leu Gly Gly Ser Asp Thr Pro Glu Pro Ser 
145                 150                 155                 160 


Tyr Leu Asp Met Asp Ser Tyr Pro Glu Ala Ala Ala Ala Ala Val Ala 
                165                 170                 175     


Ala Gly Val Lys Pro Ser Gln Thr Ser Pro Glu Leu Pro Ser Glu Gly 
            180                 185                 190         


Gly Ala Gly Ser Gly Leu Leu Leu Leu Pro Pro Ser Gly Gly Gly Leu 
        195                 200                 205             


Pro Ser Ala Gln Ser His Gln Gln Val Thr Ser Leu Ala Pro Thr Thr 
    210                 215                 220                 


Arg Tyr Pro Ala Leu Pro Arg Pro Leu Thr Gln Gln Thr Leu Thr Ser 
225                 230                 235                 240 


Gln Pro Asp Pro Ser Ser Glu Glu Arg Pro Pro Ala Leu Pro Leu Pro 
                245                 250                 255     


Leu Pro Gly Gly Glu Glu Lys Ala Lys Leu Ile Gly Gln Ile Lys Pro 
            260                 265                 270         


Glu Leu Tyr Gln Gly Thr Gly Pro Gly Gly Arg Arg Ser Gly Gly Gly 
        275                 280                 285             


Pro Gly Ser Gly Glu Ala Gly Thr Gly Ala Pro Cys Gly Arg Ile Ser 
    290                 295                 300                 


Phe Ala Leu Arg Tyr Leu Tyr Gly Ser Asp Gln Leu Val Val Arg Ile 
305                 310                 315                 320 


Leu Gln Ala Leu Asp Leu Pro Ala Lys Asp Ser Asn Gly Phe Ser Asp 
                325                 330                 335     


Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Lys Lys Phe Gln 
            340                 345                 350         


Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn Glu Thr Phe 
        355                 360                 365             


Gln Phe Ser Val Pro Leu Ala Glu Leu Ala Gln Arg Lys Leu His Phe 
    370                 375                 380                 


Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly Gln 
385                 390                 395                 400 


Val Val Leu Asp Asn Leu Leu Glu Leu Ala Glu Gln Pro Pro Asp Arg 
                405                 410                 415     


Pro Leu Trp Arg Asp Ile Val Glu Gly Gly Ser Glu Lys Ala Asp Leu 
            420                 425                 430         


Gly Glu Leu Asn Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg Leu 
        435                 440                 445             


Thr Val Thr Ile Ile Lys Ala Ser Asn Leu Lys Ala Met Asp Leu Thr 
    450                 455                 460                 


Gly Phe Ser Asp Pro Tyr Val Lys Ala Ser Leu Ile Ser Glu Gly Arg 
465                 470                 475                 480 


Arg Leu Lys Lys Arg Lys Thr Ser Ile Lys Lys Asn Thr Leu Asn Pro 
                485                 490                 495     


Thr Tyr Asn Glu Ala Leu Val Phe Asp Val Ala Pro Glu Ser Val Glu 
            500                 505                 510         


Asn Val Gly Leu Ser Ile Ala Val Val Asp Tyr Asp Cys Ile Gly His 
        515                 520                 525             


Asn Glu Val Ile Gly Val Cys Arg Val Gly Pro Asp Ala Ala Asp Pro 
    530                 535                 540                 


His Gly Arg Glu His Trp Ala Glu Met Leu Ala Asn Pro Arg Lys Pro 
545                 550                 555                 560 


Val Glu His Trp His Gln Leu Val Glu Glu Lys Thr Val Thr Ser Phe 
                565                 570                 575     


Thr Lys Gly Ser Lys Gly Leu Ser Glu Lys Glu Asn Ser Glu 
            580                 585                 590 


<210>  11
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  12
<211>  948
<212>  PRT
<213>  Homo Sapiens

<400>  12

Val Tyr Val Pro Ile Leu Pro Ala Ser Leu Leu His Phe Leu Asp Ala 
1               5                   10                  15      


Pro Val Pro Tyr Leu Met Gly Leu His Ser Asn Gly Leu Asp Asp Arg 
            20                  25                  30          


Ser Lys Leu Glu Leu Pro Gln Glu Ala Asn Leu Cys Phe Val Asp Ile 
        35                  40                  45              


Asp Asn His Phe Ile Glu Leu Pro Glu Asp Leu Pro Gln Phe Pro Asn 
    50                  55                  60                  


Lys Leu Glu Phe Val Gln Glu Val Ser Glu Ile Leu Met Ala Phe Gly 
65                  70                  75                  80  


Ile Pro Pro Glu Gly Asn Leu His Cys Ser Glu Ser Ala Ser Lys Leu 
                85                  90                  95      


Lys Arg Leu Arg Ala Ser Glu Leu Val Ser Asp Lys Arg Asn Gly Asn 
            100                 105                 110         


Ile Ala Gly Ser Pro Leu His Ser Tyr Glu Leu Leu Lys Glu Asn Glu 
        115                 120                 125             


Thr Ile Ala Arg Leu Gln Ala Leu Val Lys Arg Thr Gly Val Ser Leu 
    130                 135                 140                 


Glu Lys Leu Glu Val Arg Glu Asp Pro Ser Ser Asn Lys Asp Leu Lys 
145                 150                 155                 160 


Val Gln Cys Asp Glu Glu Glu Leu Arg Ile Tyr Gln Leu Asn Ile Gln 
                165                 170                 175     


Ile Arg Glu Val Phe Ala Asn Arg Phe Thr Gln Met Phe Ala Asp Tyr 
            180                 185                 190         


Glu Val Phe Val Ile Gln Pro Ser Gln Asp Lys Glu Ser Trp Phe Thr 
        195                 200                 205             


Asn Arg Glu Gln Met Gln Asn Phe Asp Lys Ala Ser Phe Leu Ser Asp 
    210                 215                 220                 


Gln Pro Glu Pro Tyr Leu Pro Phe Leu Ser Arg Phe Leu Glu Thr Gln 
225                 230                 235                 240 


Met Phe Ala Ser Phe Ile Asp Asn Lys Ile Met Cys His Asp Asp Asp 
                245                 250                 255     


Asp Lys Asp Pro Val Leu Arg Val Phe Asp Ser Arg Val Asp Lys Ile 
            260                 265                 270         


Arg Leu Leu Asn Val Arg Thr Pro Thr Leu Arg Thr Ser Met Tyr Gln 
        275                 280                 285             


Lys Cys Thr Thr Val Asp Glu Ala Glu Lys Ala Ile Glu Leu Arg Leu 
    290                 295                 300                 


Ala Lys Ile Asp His Thr Ala Ile His Pro His Leu Leu Asp Met Lys 
305                 310                 315                 320 


Ile Gly Gln Gly Lys Tyr Glu Pro Gly Phe Phe Pro Lys Leu Gln Ser 
                325                 330                 335     


Asp Val Leu Ser Thr Gly Pro Ala Ser Asn Lys Trp Thr Lys Arg Asn 
            340                 345                 350         


Ala Pro Ala Gln Trp Arg Arg Lys Asp Arg Gln Lys Gln His Thr Glu 
        355                 360                 365             


His Leu Arg Leu Asp Asn Asp Gln Arg Glu Lys Tyr Ile Gln Glu Ala 
    370                 375                 380                 


Arg Thr Met Gly Ser Thr Ile Arg Gln Pro Lys Leu Ser Asn Leu Ser 
385                 390                 395                 400 


Pro Ser Val Ile Ala Gln Thr Asn Trp Lys Phe Val Glu Gly Leu Leu 
                405                 410                 415     


Lys Glu Cys Arg Asn Lys Thr Lys Arg Met Leu Val Glu Lys Met Gly 
            420                 425                 430         


Arg Glu Ala Val Glu Leu Gly His Gly Glu Val Asn Ile Thr Gly Val 
        435                 440                 445             


Glu Glu Asn Thr Leu Ile Ala Ser Leu Cys Asp Leu Leu Glu Arg Ile 
    450                 455                 460                 


Trp Ser His Gly Leu Gln Val Lys Gln Gly Lys Ser Ala Leu Trp Ser 
465                 470                 475                 480 


His Leu Leu His Tyr Gln Asp Asn Arg Gln Arg Lys Leu Thr Ser Gly 
                485                 490                 495     


Ser Leu Ser Thr Ser Gly Ile Leu Leu Asp Ser Glu Arg Arg Lys Ser 
            500                 505                 510         


Asp Ala Ser Ser Leu Met Pro Pro Leu Arg Ile Ser Leu Ile Gln Asp 
        515                 520                 525             


Met Arg His Ile Gln Asn Ile Gly Glu Ile Lys Thr Asp Val Gly Lys 
    530                 535                 540                 


Ala Arg Ala Trp Val Arg Leu Ser Met Glu Lys Lys Leu Leu Ser Arg 
545                 550                 555                 560 


His Leu Lys Gln Leu Leu Ser Asp His Glu Leu Thr Lys Lys Leu Tyr 
                565                 570                 575     


Lys Arg Tyr Ala Phe Leu Arg Cys Asp Asp Glu Lys Glu Gln Phe Leu 
            580                 585                 590         


Tyr His Leu Leu Ser Phe Asn Ala Val Asp Tyr Phe Cys Phe Thr Asn 
        595                 600                 605             


Val Phe Thr Thr Ile Leu Ile Pro Tyr His Ile Leu Ile Val Pro Ser 
    610                 615                 620                 


Lys Lys Leu Gly Gly Ser Met Phe Thr Ala Asn Pro Trp Ile Cys Ile 
625                 630                 635                 640 


Ser Gly Glu Leu Gly Glu Thr Gln Ile Met Gln Ile Pro Arg Asn Val 
                645                 650                 655     


Leu Glu Met Thr Phe Glu Cys Gln Asn Leu Gly Lys Leu Thr Thr Val 
            660                 665                 670         


Gln Ile Gly His Asp Asn Ser Gly Leu Tyr Ala Lys Trp Leu Val Glu 
        675                 680                 685             


Tyr Val Met Val Arg Asn Glu Ile Thr Gly His Thr Tyr Lys Phe Pro 
    690                 695                 700                 


Cys Gly Arg Trp Leu Gly Lys Gly Met Asp Asp Gly Ser Leu Glu Arg 
705                 710                 715                 720 


Ile Leu Val Gly Glu Leu Leu Thr Ser Gln Pro Glu Val Asp Glu Arg 
                725                 730                 735     


Pro Cys Arg Thr Pro Pro Leu Gln Gln Ser Pro Ser Val Ile Arg Arg 
            740                 745                 750         


Leu Val Thr Ile Ser Pro Asn Asn Lys Pro Lys Leu Asn Thr Gly Gln 
        755                 760                 765             


Ile Gln Glu Ser Ile Gly Glu Ala Val Asn Gly Ile Val Lys His Phe 
    770                 775                 780                 


His Lys Pro Glu Lys Glu Arg Gly Ser Leu Thr Leu Leu Leu Cys Gly 
785                 790                 795                 800 


Glu Cys Gly Leu Val Ser Ala Leu Glu Gln Ala Phe Gln His Gly Phe 
                805                 810                 815     


Lys Ser Pro Arg Leu Phe Lys Asn Val Phe Ile Trp Asp Phe Leu Glu 
            820                 825                 830         


Lys Ala Gln Thr Tyr Tyr Glu Thr Leu Glu Lys Asn Glu Val Val Pro 
        835                 840                 845             


Glu Glu Asn Trp His Thr Arg Ala Arg Asn Phe Cys Arg Phe Val Thr 
    850                 855                 860                 


Ala Ile Asn Asn Thr Pro Arg Asn Ile Gly Lys Asp Gly Lys Phe Gln 
865                 870                 875                 880 


Met Leu Val Cys Leu Gly Ala Arg Asp His Leu Leu His His Trp Ile 
                885                 890                 895     


Ala Leu Leu Ala Asp Cys Pro Ile Thr Ala His Met Tyr Glu Asp Val 
            900                 905                 910         


Ala Leu Ile Lys Asp His Thr Leu Val Asn Ser Leu Ile Arg Val Leu 
        915                 920                 925             


Gln Thr Leu Gln Glu Phe Asn Ile Thr Leu Glu Thr Ser Leu Val Lys 
    930                 935                 940                 


Gly Ile Asp Ile 
945             


<210>  13
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Ser Ala Ser Ala Val Tyr Val Leu Asp Leu Lys Gly Lys Val Leu 
1               5                   10                  15      


Ile Cys Arg Asn Tyr Arg Gly Asp Val Asp Met Ser Glu Val Glu His 
            20                  25                  30          


Phe Met Pro Ile Leu Met Glu Lys Glu Glu Glu Gly Met Leu Ser Pro 
        35                  40                  45              


Ile Leu Ala His Gly Gly Val Arg Phe Met Trp Ile Lys His Asn Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Ser Lys Lys Asn Ala Cys Val Ser Leu Val 
65                  70                  75                  80  


Phe Ser Phe Leu Tyr Lys Val Val Gln Val Phe Ser Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Ile Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Tyr Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Glu Gly His Lys Leu Glu Thr 
    130                 135                 140                 


Gly Ala Pro Arg Pro Pro Ala Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Arg Lys Asn Glu Val Phe Leu Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Val Ser Ala Asn Gly Asn Val Leu Arg Ser 
            180                 185                 190         


Glu Ile Val Gly Ser Ile Lys Met Arg Val Phe Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Leu Arg Leu Gly Leu Asn Asp Lys Val Leu Phe Asp Asn Thr Gly 
    210                 215                 220                 


Arg Gly Lys Ser Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln 
225                 230                 235                 240 


Cys Val Arg Leu Ser Arg Phe Glu Asn Asp Arg Thr Ile Ser Phe Ile 
                245                 250                 255     


Pro Pro Asp Gly Glu Phe Glu Leu Met Ser Tyr Arg Leu Asn Thr His 
            260                 265                 270         


Val Lys Pro Leu Ile Trp Ile Glu Ser Val Ile Glu Lys His Ser His 
        275                 280                 285             


Ser Arg Ile Glu Tyr Met Ile Lys Ala Lys Ser Gln Phe Lys Arg Arg 
    290                 295                 300                 


Ser Thr Ala Asn Asn Val Glu Ile His Ile Pro Val Pro Asn Asp Ala 
305                 310                 315                 320 


Asp Ser Pro Lys Phe Lys Thr Thr Val Gly Ser Val Lys Trp Val Pro 
                325                 330                 335     


Glu Asn Ser Glu Ile Val Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys 
            340                 345                 350         


Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Ala Glu 
        355                 360                 365             


Asp Lys Glu Gly Lys Pro Pro Ile Ser Val Lys Phe Glu Ile Pro Tyr 
    370                 375                 380                 


Phe Thr Thr Ser Gly Ile Gln Val Arg Tyr Leu Lys Ile Ile Glu Lys 
385                 390                 395                 400 


Ser Gly Tyr Gln Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Asn Gly 
                405                 410                 415     


Asp Tyr Gln Leu Arg Thr Gln 
            420             


<210>  14
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  14

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
1               5                   10                  15      


Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
            20                  25                  30          


Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
        35                  40                  45              


Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 
    50                  55                  60                  


Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 
65                  70                  75                  80  


Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                85                  90                  95      


Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
            100                 105                 110         


Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
        115                 120                 125             


Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
145                 150                 155                 160 


Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                165                 170                 175     


Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 
            180                 185                 190         


Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 
        195                 200                 205             


Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 
    210                 215                 220                 


Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 
225                 230                 235                 240 


Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 
                245                 250                 255     


Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 
            260                 265                 270         


Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 
        275                 280                 285             


Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 
    290                 295                 300                 


Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 
                325                 330                 335     


Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 
            340                 345                 350         


Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 
        355                 360                 365             


Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 
    370                 375                 380                 


Pro Ala Glu Cys Lys Gln Gln 
385                 390     


<210>  15
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  15

Ile Pro Asp Gln Ala Arg Val Ala Pro Ser Ser Ser Asp Pro Lys Ser 
1               5                   10                  15      


Lys Phe Phe Glu Leu Ile Gln Gly Thr Glu Ile Asp Ile Phe Ser Tyr 
            20                  25                  30          


Lys Pro Thr Leu Leu Thr Ser Lys Thr Leu Glu Lys Ile Arg Pro Val 
        35                  40                  45              


Phe Asp Tyr Arg Cys Met Val Ser Gly Ser Glu Gln Lys Phe Leu Ile 
    50                  55                  60                  


Gly Leu Gly Lys Ser Gln Ile Tyr Thr Trp Asp Gly Arg Gln Ser Asp 
65                  70                  75                  80  


Arg Trp Ile Lys Leu Asp Leu Lys Thr Glu Leu Pro Arg Asp Thr Leu 
                85                  90                  95      


Leu Ser Val Glu Ile Val His Glu Leu Lys Gly Glu Gly Lys Ala Gln 
            100                 105                 110         


Arg Lys Ile Ser Ala Ile His Ile Leu Asp Val Leu Val Leu Asn Gly 
        115                 120                 125             


Thr Asp Val Arg Glu Gln His Phe Asn Gln Arg Ile Gln Leu Ala Glu 
    130                 135                 140                 


Lys Phe Val Lys Ala Val Ser Lys Pro Ser Arg Pro Asp Met Asn Pro 
145                 150                 155                 160 


Ile Arg Val Lys Glu Val Tyr Arg Leu Glu Glu Met Glu Lys Ile Phe 
                165                 170                 175     


Val Arg Leu Glu Met Lys Ile Ile Lys Gly Ser Ser Gly Thr Pro Lys 
            180                 185                 190         


Leu Ser Tyr Thr Gly Arg Asp Asp Arg His Phe Val Pro Met Gly Leu 
        195                 200                 205             


Tyr Ile Val Arg Thr Val Asn Glu Pro Trp Thr Met Gly Phe Ser Lys 
    210                 215                 220                 


Ser Phe Lys Lys Lys Phe Phe Tyr Asn Lys Lys Thr Lys Asp Ser Thr 
225                 230                 235                 240 


Phe Asp Leu Pro Ala Asp Ser Ile Ala Pro Phe His Ile Cys Tyr Tyr 
                245                 250                 255     


Gly Arg Leu Phe Trp Glu Trp Gly Asp Gly Ile Arg Val His Asp Ser 
            260                 265                 270         


Gln Lys Pro Gln Asp Gln Asp Lys Leu Ser Lys Glu Asp Val Leu Ser 
        275                 280                 285             


Phe Ile Gln Met His Arg Ala 
    290                 295 


<210>  16
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Ala Ala Gly Thr Leu Tyr Thr Tyr Pro Glu Asn Trp Arg Ala Phe 
1               5                   10                  15      


Lys Ala Leu Ile Ala Ala Gln Tyr Ser Gly Ala Gln Val Arg Val Leu 
            20                  25                  30          


Ser Ala Pro Pro His Phe His Phe Gly Gln Thr Asn Arg Thr Pro Glu 
        35                  40                  45              


Phe Leu Arg Lys Phe Pro Ala Gly Lys Val Pro Ala Phe Glu Gly Asp 
    50                  55                  60                  


Asp Gly Phe Cys Val Phe Glu Ser Asn Ala Ile Ala Tyr Tyr Val Ser 
65                  70                  75                  80  


Asn Glu Glu Leu Arg Gly Ser Thr Pro Glu Ala Ala Ala Gln Val Val 
                85                  90                  95      


Gln Trp Val Ser Phe Ala Asp Ser Asp Ile Val Pro Pro Ala Ser Thr 
            100                 105                 110         


Trp Val Phe Pro Thr Leu Gly Ile Met His His Asn Lys Gln Ala Thr 
        115                 120                 125             


Glu Asn Ala Lys Glu Glu Val Arg Arg Ile Leu Gly Leu Leu Asp Ala 
    130                 135                 140                 


Tyr Leu Lys Thr Arg Thr Phe Leu Val Gly Glu Arg Val Thr Leu Ala 
145                 150                 155                 160 


Asp Ile Thr Val Val Cys Thr Leu Leu Trp Leu Tyr Lys Gln Val Leu 
                165                 170                 175     


Glu Pro Ser Phe Arg Gln Ala Phe Pro Asn Thr Asn Arg Trp Phe Leu 
            180                 185                 190         


Thr Cys Ile Asn Gln Pro Gln Phe Arg Ala Val Leu Gly Glu Val Lys 
        195                 200                 205             


Leu Cys Glu Lys Met Ala Gln Phe Asp Ala Lys Lys Phe Ala Glu Thr 
    210                 215                 220                 


Gln Pro Lys Lys Asp Thr Pro Arg Lys Glu Lys Gly Ser Arg Glu Glu 
225                 230                 235                 240 


Lys Gln Lys Pro Gln Ala Glu Arg Lys Glu Glu Lys Lys Ala Ala Ala 
                245                 250                 255     


Pro Ala Pro Glu Glu Glu Met Asp Glu Cys Glu Gln Ala Leu Ala Ala 
            260                 265                 270         


Glu Pro Lys Ala Lys Asp Pro Phe Ala His Leu Pro Lys Ser Thr Phe 
        275                 280                 285             


Val Leu Asp Glu Phe Lys Arg Lys Tyr Ser Asn Glu Asp Thr Leu Ser 
    290                 295                 300                 


Val Ala Leu Pro Tyr Phe Trp Glu His Phe Asp Lys Asp Gly Trp Ser 
305                 310                 315                 320 


Leu Trp Tyr Ser Glu Tyr Arg Phe Pro Glu Glu Leu Thr Gln Thr Phe 
                325                 330                 335     


Met Ser Cys Asn Leu Ile Thr Gly Met Phe Gln Arg Leu Asp Lys Leu 
            340                 345                 350         


Arg Lys Asn Ala Phe Ala Ser Val Ile Leu Phe Gly Thr Asn Asn Ser 
        355                 360                 365             


Ser Ser Ile Ser Gly Val Trp Val Phe Arg Gly Gln Glu Leu Ala Phe 
    370                 375                 380                 


Pro Leu Ser Pro Asp Trp Gln Val Asp Tyr Glu Ser Tyr Thr Trp Arg 
385                 390                 395                 400 


Lys Leu Asp Pro Gly Ser Glu Glu Thr Gln Thr Leu Val Arg Glu Tyr 
                405                 410                 415     


Phe Ser Trp Glu Gly Ala Phe Gln His Val Gly Lys Ala Phe Asn Gln 
            420                 425                 430         


Gly Lys Ile Phe Lys 
        435         


<210>  17
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Val Leu Asp Leu Asp Leu Phe Arg Val Asp Lys Gly Gly Asp Pro 
1               5                   10                  15      


Ala Leu Ile Arg Glu Thr Gln Glu Lys Arg Phe Lys Asp Pro Gly Leu 
            20                  25                  30          


Val Asp Gln Leu Val Lys Ala Asp Ser Glu Trp Arg Arg Cys Arg Phe 
        35                  40                  45              


Arg Ala Asp Asn Leu Asn Lys Leu Lys Asn Leu Cys Ser Lys Thr Ile 
    50                  55                  60                  


Gly Glu Lys Met Lys Lys Lys Glu Pro Val Gly Asp Asp Glu Ser Val 
65                  70                  75                  80  


Pro Glu Asn Val Leu Ser Phe Asp Asp Leu Thr Ala Asp Ala Leu Ala 
                85                  90                  95      


Asn Leu Lys Val Ser Gln Ile Lys Lys Val Arg Leu Leu Ile Asp Glu 
            100                 105                 110         


Ala Ile Leu Lys Cys Asp Ala Glu Arg Ile Lys Leu Glu Ala Glu Arg 
        115                 120                 125             


Phe Glu Asn Leu Arg Glu Ile Gly Asn Leu Leu His Pro Ser Val Pro 
    130                 135                 140                 


Ile Ser Asn Asp Glu Asp Val Asp Asn Lys Val Glu Arg Ile Trp Gly 
145                 150                 155                 160 


Asp Cys Thr Val Arg Lys Lys Tyr Ser His Val Asp Leu Val Val Met 
                165                 170                 175     


Val Asp Gly Phe Glu Gly Glu Lys Gly Ala Val Val Ala Gly Ser Arg 
            180                 185                 190         


Gly Tyr Phe Leu Lys Gly Val Leu Val Phe Leu Glu Gln Ala Leu Ile 
        195                 200                 205             


Gln Tyr Ala Leu Arg Thr Leu Gly Ser Arg Gly Tyr Ile Pro Ile Tyr 
    210                 215                 220                 


Thr Pro Phe Phe Met Arg Lys Glu Val Met Gln Glu Val Ala Gln Leu 
225                 230                 235                 240 


Ser Gln Phe Asp Glu Glu Leu Tyr Lys Val Ile Gly Lys Gly Ser Glu 
                245                 250                 255     


Lys Ser Asp Asp Asn Ser Tyr Asp Glu Lys Tyr Leu Ile Ala Thr Ser 
            260                 265                 270         


Glu Gln Pro Ile Ala Ala Leu His Arg Asp Glu Trp Leu Arg Pro Glu 
        275                 280                 285             


Asp Leu Pro Ile Lys Tyr Ala Gly Leu Ser Thr Cys Phe Arg Gln Glu 
    290                 295                 300                 


Val Gly Ser His Gly Arg Asp Thr Arg Gly Ile Phe Arg Val His Gln 
305                 310                 315                 320 


Phe Glu Lys Ile Glu Gln Phe Val Tyr Ser Ser Pro His Asp Asn Lys 
                325                 330                 335     


Ser Trp Glu Met Phe Glu Glu Met Ile Thr Thr Ala Glu Glu Phe Tyr 
            340                 345                 350         


Gln Ser Leu Gly Ile Pro Tyr His Ile Val Asn Ile Val Ser Gly Ser 
        355                 360                 365             


Leu Asn His Ala Ala Ser Lys Lys Leu Asp Leu Glu Ala Trp Phe Pro 
    370                 375                 380                 


Gly Ser Gly Ala Phe Arg Glu Leu Val Ser Cys Ser Asn Cys Thr Asp 
385                 390                 395                 400 


Tyr Gln Ala Arg Arg Leu Arg Ile Arg Tyr Gly Gln Thr Lys Lys Met 
                405                 410                 415     


Met Asp Lys Val Glu Phe Val His Met Leu Asn Ala Thr Met Cys Ala 
            420                 425                 430         


Thr Thr Cys Thr Ile Cys Ala Ile Leu Glu Asn Tyr Gln Thr Glu Lys 
        435                 440                 445             


Gly Ile Thr Val Pro Glu Lys Leu Lys Glu Phe Met Pro Pro Gly Leu 
    450                 455                 460                 


Gln Glu Leu Ile Pro Phe Val Lys Pro Ala Pro Ile Glu Gln Glu Pro 
465                 470                 475                 480 


Ser Lys Lys Gln Lys Lys Gln His Glu Gly Ser Lys Lys Lys Ala Ala 
                485                 490                 495     


Ala Arg Asp Val Thr Leu Glu Asn Arg Leu Gln Asn Met Glu Val Thr 
            500                 505                 510         


Asp Ala 
        


<210>  18
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  18

Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 
            20                  25                  30          


Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 
        35                  40                  45              


Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 
    50                  55                  60                  


Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 
65                  70                  75                  80  


Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 
                85                  90                  95      


Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 
            100                 105                 110         


Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 
        115                 120                 125             


Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 
    130                 135                 140                 


Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 
145                 150                 155                 160 


Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 
                165                 170                 175     


Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 
            180                 185                 190         


Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 
        195                 200                 205             


Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 
    210                 215                 220                 


Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 
225                 230                 235                 240 


Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 
                245                 250                 255     


Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 
            260                 265                 270         


Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 
        275                 280                 285             


Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 
305                 310                 315             


<210>  19
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  19

Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu Ala 
1               5                   10                  15      


Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala Asp 
65                  70                  75                  80  


Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr Ala 
                85                  90                  95      


Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr Ser 
        115                 120                 125             


Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala Glu 
                165                 170                 175     


Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp Ser 
    210                 215                 220                 


Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His Pro 
            260                 265                 270         


Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val Phe 
        275                 280                 285             


Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val Ile 
    290                 295                 300                 


Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Phe Leu 
                325                 330             


<210>  20
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Gly Glu Pro Gln Gly Ser Met Arg Ile Leu Val Thr Gly Gly Ser 
1               5                   10                  15      


Gly Leu Val Gly Lys Ala Ile Gln Lys Val Val Ala Asp Gly Ala Gly 
            20                  25                  30          


Leu Pro Gly Glu Asp Trp Val Phe Val Ser Ser Lys Asp Ala Asp Leu 
        35                  40                  45              


Thr Asp Thr Ala Gln Thr Arg Ala Leu Phe Glu Lys Val Gln Pro Thr 
    50                  55                  60                  


His Val Ile His Leu Ala Ala Met Val Gly Gly Leu Phe Arg Asn Ile 
65                  70                  75                  80  


Lys Tyr Asn Leu Asp Phe Trp Arg Lys Asn Val His Met Asn Asp Asn 
                85                  90                  95      


Val Leu His Ser Ala Phe Glu Val Gly Ala Arg Lys Val Val Ser Cys 
            100                 105                 110         


Leu Ser Thr Cys Ile Phe Pro Asp Lys Thr Thr Tyr Pro Ile Asp Glu 
        115                 120                 125             


Thr Met Ile His Asn Gly Pro Pro His Asn Ser Asn Phe Gly Tyr Ser 
    130                 135                 140                 


Tyr Ala Lys Arg Met Ile Asp Val Gln Asn Arg Ala Tyr Phe Gln Gln 
145                 150                 155                 160 


Tyr Gly Cys Thr Phe Thr Ala Val Ile Pro Thr Asn Val Phe Gly Pro 
                165                 170                 175     


His Asp Asn Phe Asn Ile Glu Asp Gly His Val Leu Pro Gly Leu Ile 
            180                 185                 190         


His Lys Val His Leu Ala Lys Ser Ser Gly Ser Ala Leu Thr Val Trp 
        195                 200                 205             


Gly Thr Gly Asn Pro Arg Arg Gln Phe Ile Tyr Ser Leu Asp Leu Ala 
    210                 215                 220                 


Gln Leu Phe Ile Trp Val Leu Arg Glu Tyr Asn Glu Val Glu Pro Ile 
225                 230                 235                 240 


Ile Leu Ser Val Gly Glu Glu Asp Glu Val Ser Ile Lys Glu Ala Ala 
                245                 250                 255     


Glu Ala Val Val Glu Ala Met Asp Phe His Gly Glu Val Thr Phe Asp 
            260                 265                 270         


Thr Thr Lys Ser Asp Gly Gln Phe Lys Lys Thr Ala Ser Asn Ser Lys 
        275                 280                 285             


Leu Arg Thr Tyr Leu Pro Asp Phe Arg Phe Thr Pro Phe Lys Gln Ala 
    290                 295                 300                 


Val Lys Glu Thr Cys Ala Trp Phe Thr Asp Asn Tyr Glu Gln Ala Arg 
305                 310                 315                 320 


Lys 
    


<210>  21
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  21

Met Asn Val Ile Tyr Phe Pro Leu His Leu Phe Val Val Tyr Ser Arg 
1               5                   10                  15      


Ala Tyr Thr Ser Leu Val Leu Val Gly Cys Thr Asn Leu Cys Ala Val 
            20                  25                  30          


Leu Phe Ala Arg Cys Leu Asp Asp His Leu Val Ser Leu Arg Met Ser 
        35                  40                  45              


Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile Leu Lys Ile Arg Trp 
    50                  55                  60                  


Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn Ser Thr Val Asp Ser 
65                  70                  75                  80  


Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr Gly Ala Asn Gly Gly 
                85                  90                  95      


Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu Pro Leu Ala Ser Ile 
            100                 105                 110         


Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln Asn Ser Pro Ser Trp 
        115                 120                 125             


Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe Glu Phe Thr Ala Glu 
    130                 135                 140                 


Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro Glu Val Asp Asp Gly 
145                 150                 155                 160 


Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser Ser Cys Arg Thr Ser 
                165                 170                 175     


Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr Met Glu Pro Cys Thr 
            180                 185                 190         


Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala Glu Gln Thr Phe Lys 
        195                 200                 205             


Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu Cys Asp Val Ile Leu 
    210                 215                 220                 


Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg Leu Val Leu Ser Ser 
225                 230                 235                 240 


Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn Asp Val Arg Glu Ala 
                245                 250                 255     


Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu Pro Asn Ser Leu Trp 
            260                 265                 270         


Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu Glu Leu Lys Glu Asp 
        275                 280                 285             


Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu Leu Gln Leu Ser Gln 
    290                 295                 300                 


Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys Gln Leu His Pro Ser 
305                 310                 315                 320 


Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala Gln Gly Cys Thr Asp 
                325                 330                 335     


Leu His Lys Val Ala His Asn Tyr Thr Met Glu His Phe Met Glu Val 
            340                 345                 350         


Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala Ser Glu Ile Ala Lys 
        355                 360                 365             


Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn Glu Glu Thr Ile Leu 
    370                 375                 380                 


Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu Glu Gln Arg Arg Lys 
385                 390                 395                 400 


Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu Pro Leu Leu Ala Pro 
                405                 410                 415     


Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu Phe Arg Asp Asp Ile 
            420                 425                 430         


Glu Cys Arg Lys Leu Ile Met Glu Ala Met Lys Tyr His Leu Leu Pro 
        435                 440                 445             


Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser 
    450                 455                 460                 


Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met Asp Ser Thr Lys Gly 
465                 470                 475                 480 


Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr Asn Met Trp Thr Pro 
                485                 490                 495     


Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe Gly Val Ala Val Leu 
            500                 505                 510         


Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp Gly Leu Lys Thr Leu 
        515                 520                 525             


Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys Thr Trp Ser Val Met 
    530                 535                 540                 


Pro Pro Met Ser Thr His Arg His Gly Leu Gly Val Ala Val Leu Glu 
545                 550                 555                 560 


Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly Trp Ser Tyr Leu Asn 
                565                 570                 575     


Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln Trp Asn Phe Val Ala 
            580                 585                 590         


Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val Ala Val Leu Ser Gly 
        595                 600                 605             


Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser Ser Cys Leu Lys Ser 
    610                 615                 620                 


Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp Thr Leu Cys Ala Gln 
625                 630                 635                 640 


Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr Thr Trp Asn Gly Leu 
                645                 650                 655     


Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala Ser Asn Leu Thr Ser 
            660                 665                 670         


Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro Lys Thr Asp Met Trp 
        675                 680                 685             


Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp Ala Val Gly Val Cys 
    690                 695                 700                 


Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly Tyr Asp Gly Gln Ala 
705                 710                 715                 720 


Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln Thr Asn Glu 
                725                 730                 


<210>  22
<211>  694
<212>  PRT
<213>  Homo Sapiens

<400>  22

Ile Leu Thr Gly Ala His Arg Phe Thr Leu Ser Ala Asn Val Gly Asp 
1               5                   10                  15      


Leu Lys Leu Arg Arg Met Pro Glu Val Pro Gly Leu Gln Ser Ala Pro 
            20                  25                  30          


Ser Cys Trp Thr Val Leu Cys Gln Asp Arg Val Ala His Ile Leu Leu 
        35                  40                  45              


Ala Val Gly Pro Asp Leu Tyr Leu Leu Asp His Ala Ala Cys Ser Ala 
    50                  55                  60                  


Val Thr Pro Pro Gly Leu Ala Pro Gly Val Ser Ser Phe Leu Gln Met 
65                  70                  75                  80  


Ala Val Ser Phe Thr Tyr Arg His Leu Ala Leu Phe Thr Asp Thr Gly 
                85                  90                  95      


Tyr Ile Trp Met Gly Thr Ala Ser Leu Lys Glu Lys Leu Cys Glu Phe 
            100                 105                 110         


Asn Cys Asn Ile Arg Ala Pro Pro Lys Gln Met Val Trp Cys Ser Arg 
        115                 120                 125             


Pro Arg Ser Lys Glu Arg Ala Val Val Val Ala Trp Glu Arg Arg Leu 
    130                 135                 140                 


Met Val Val Gly Asp Ala Pro Glu Ser Ile Gln Phe Val Leu Asp Glu 
145                 150                 155                 160 


Asp Ser Tyr Leu Val Pro Glu Leu Asp Gly Val Arg Ile Phe Ser Arg 
                165                 170                 175     


Ser Thr His Glu Phe Leu His Glu Val Pro Ala Ala Ser Glu Glu Ile 
            180                 185                 190         


Phe Lys Ile Ala Ser Met Ala Pro Gly Ala Leu Leu Leu Glu Ala Gln 
        195                 200                 205             


Lys Glu Tyr Glu Lys Glu Ser Gln Lys Ala Asp Glu Tyr Leu Arg Glu 
    210                 215                 220                 


Ile Gln Glu Leu Gly Gln Leu Thr Gln Ala Val Gln Gln Cys Ile Glu 
225                 230                 235                 240 


Ala Ala Gly His Glu His Gln Pro Asp Met Gln Lys Ser Leu Leu Arg 
                245                 250                 255     


Ala Ala Ser Phe Gly Lys Cys Phe Leu Asp Arg Phe Pro Pro Asp Ser 
            260                 265                 270         


Phe Val His Met Cys Gln Asp Leu Arg Val Leu Asn Ala Val Arg Asp 
        275                 280                 285             


Tyr His Ile Gly Ile Pro Leu Thr Tyr Ser Gln Tyr Lys Gln Leu Thr 
    290                 295                 300                 


Ile Gln Val Leu Leu Asp Arg Leu Val Leu Arg Arg Leu Tyr Pro Leu 
305                 310                 315                 320 


Ala Ile Gln Ile Cys Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly Val 
                325                 330                 335     


Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys Val Gln Gln Lys Asp 
            340                 345                 350         


Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn Gln Lys Leu Gly Asp 
        355                 360                 365             


Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly Cys 
    370                 375                 380                 


Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg Ser 
385                 390                 395                 400 


Gly Glu Gln Val Pro Leu Leu Leu Lys Met Lys Arg Ser Lys Leu Ala 
                405                 410                 415     


Leu Ser Lys Ala Ile Glu Ser Gly Asp Thr Asp Leu Val Phe Thr Val 
            420                 425                 430         


Leu Leu His Leu Lys Asn Glu Leu Asn Arg Gly Asp Phe Phe Met Thr 
        435                 440                 445             


Leu Arg Asn Gln Pro Met Ala Leu Ser Leu Tyr Arg Gln Phe Cys Lys 
    450                 455                 460                 


His Gln Glu Leu Glu Thr Leu Lys Asp Leu Tyr Asn Gln Asp Asp Asn 
465                 470                 475                 480 


His Gln Glu Leu Gly Ser Phe His Ile Arg Ala Ser Tyr Ala Ala Glu 
                485                 490                 495     


Glu Arg Ile Glu Gly Arg Val Ala Ala Leu Gln Thr Ala Ala Asp Ala 
            500                 505                 510         


Phe Tyr Lys Ala Lys Asn Glu Phe Ala Ala Lys Ala Thr Glu Asp Gln 
        515                 520                 525             


Met Arg Leu Leu Arg Leu Gln Arg Arg Leu Glu Asp Glu Leu Gly Gly 
    530                 535                 540                 


Gln Phe Leu Asp Leu Ser Leu His Asp Thr Val Thr Thr Leu Ile Leu 
545                 550                 555                 560 


Gly Gly His Asn Lys Arg Ala Glu Gln Leu Ala Arg Asp Phe Arg Ile 
                565                 570                 575     


Pro Asp Lys Arg Leu Trp Trp Leu Lys Leu Thr Ala Leu Ala Asp Leu 
            580                 585                 590         


Glu Asp Trp Glu Glu Leu Glu Lys Phe Ser Lys Ser Lys Lys Ser Pro 
        595                 600                 605             


Ile Gly Tyr Leu Pro Phe Val Glu Ile Cys Met Lys Gln His Asn Lys 
    610                 615                 620                 


Tyr Glu Ala Lys Lys Tyr Ala Ser Arg Val Gly Pro Glu Gln Lys Val 
625                 630                 635                 640 


Lys Ala Leu Leu Leu Val Gly Asp Val Ala Gln Ala Ala Asp Val Ala 
                645                 650                 655     


Ile Glu His Arg Asn Glu Ala Glu Leu Ser Leu Val Leu Ser His Cys 
            660                 665                 670         


Thr Gly Ala Thr Asp Gly Ala Thr Ala Asp Lys Ile Gln Arg Ala Arg 
        675                 680                 685             


Ala Gln Ala Gln Lys Lys 
    690                 


<210>  23
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Val Ala Phe Phe Leu Gly Cys Ser Phe Ser Leu Glu Glu Ala Leu 
1               5                   10                  15      


Glu Lys Ala Gly Ala Tyr Lys Thr Thr Val Pro Cys Val Thr His Ala 
            20                  25                  30          


Gly Phe Cys Cys Pro Leu Val Val Thr Met Arg Pro Ile Pro Lys Asp 
        35                  40                  45              


Lys Leu Glu Gly Leu Val Arg Ala Cys Cys Ser Leu Gly Gly Glu Gln 
    50                  55                  60                  


Gly Gln Pro Val His Met Gly Asp Pro Glu Leu Leu Gly Ile Lys Glu 
65                  70                  75                  80  


Leu Ser Lys Pro Ala Tyr Gly Asp Ala Met Val Cys Pro Pro Gly Glu 
                85                  90                  95      


Val Pro Val Phe Trp Pro Ser Pro Leu Thr Ser Leu Gly Ala Val Ser 
            100                 105                 110         


Ser Cys Glu Thr Pro Leu Ala Phe Ala Ser Ile Pro Gly Cys Thr Val 
        115                 120                 125             


Met Thr Asp Leu Lys Asp Ala Lys Ala Pro Pro Gly Cys Leu Thr Pro 
    130                 135                 140                 


Glu Arg Ile Pro Glu Val His His Ile Ser Gln Asp Pro Leu His Tyr 
145                 150                 155                 160 


Ser Ile Ala Ser Val Ser Ala Ser Gln Lys Ile Arg Glu Leu Glu Ser 
                165                 170                 175     


Met Ile Gly Ile Asp Pro Gly Asn Arg Gly Ile Gly His Leu Leu Cys 
            180                 185                 190         


Lys Asp Glu Leu Leu Lys Ala Ser Leu Ser Leu Ser His Ala Arg Ser 
        195                 200                 205             


Val Leu Ile Thr Thr Gly Phe Pro Thr His Phe Asn His Glu Pro Pro 
    210                 215                 220                 


Glu Glu Thr Asp Gly Pro Pro Gly Ala Val Ala Leu Val Ala Phe Leu 
225                 230                 235                 240 


Gln Ala Leu Glu Lys Glu Val Ala Ile Ile Val Asp Gln Arg Ala Trp 
                245                 250                 255     


Asn Leu His Gln Lys Ile Val Glu Asp Ala Val Glu Gln Gly Val Leu 
            260                 265                 270         


Lys Thr Gln Ile Pro Ile Leu Thr Tyr Gln Gly Gly Ser Val Glu Ala 
        275                 280                 285             


Ala Gln Ala Phe Leu Cys Lys Asn Gly Asp Pro Gln Thr Pro Arg Phe 
    290                 295                 300                 


Asp His Leu Val Ala Ile Glu Arg Ala Gly Arg Ala Ala Asp Gly Asn 
305                 310                 315                 320 


Tyr Tyr Asn Ala Arg Lys Met Asn Ile Lys His Leu Val Asp Pro Ile 
                325                 330                 335     


Asp Asp Leu Phe Leu Ala Ala Lys Lys Ile Pro Gly Ile Ser Ser Thr 
            340                 345                 350         


Gly Val Gly Asp Gly Gly Asn Glu Leu Gly Met Gly Lys Val Lys Glu 
        355                 360                 365             


Ala Val Arg Arg His Ile Arg His Gly Asn Val Ile Ala Cys Asp Val 
    370                 375                 380                 


Glu Ala Asp Phe Ala Val Ile Ala Gly Val Ser Asn Trp Gly Gly Tyr 
385                 390                 395                 400 


Ala Leu Ala Cys Ala Leu Tyr Ile Leu Tyr Ser Cys Ala Val His Ser 
                405                 410                 415     


Gln Tyr Leu Arg Lys Ala Val Gly Pro Ser Arg Ala Pro Gly Asp Gln 
            420                 425                 430         


Ala Trp Thr Gln Ala Leu Pro Ser Val Ile Lys Glu Glu Lys Met Leu 
        435                 440                 445             


Gly Ile Leu Val Gln His Lys Val Arg Ser Gly Val Ser Gly Ile Val 
    450                 455                 460                 


Gly Met Glu Val Asp Gly Leu Pro Phe His Asn Thr His Ala Glu Met 
465                 470                 475                 480 


Ile Gln Lys Leu Val Asp Val Thr Thr Ala Gln Val 
                485                 490         


<210>  24
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  24

Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His Gly His Arg Asn Gly Thr Gly His Gly Asn Ser 
    210                 215                 220                 


Thr His His Gly Pro Glu Tyr Met Arg Cys Ser Pro His Leu Val Leu 
225                 230                 235                 240 


Ser Ala Leu Thr Ser Asp Asn His Gly Ala Thr Tyr Ala Phe Ser Gly 
                245                 250                 255     


Thr His Tyr Trp Arg Leu Asp Thr Ser Arg Asp Gly Trp His Ser Trp 
            260                 265                 270         


Pro Ile Ala His Gln Trp Pro Gln Gly Pro Ser Ala Val Asp Ala Ala 
        275                 280                 285             


Phe Ser Trp Glu Glu Lys Leu Tyr Leu Val Gln Gly Thr Gln Val Tyr 
    290                 295                 300                 


Val Phe Leu Thr Lys Gly Gly Tyr Thr Leu Val Ser Gly Tyr Pro Lys 
305                 310                 315                 320 


Arg Leu Glu Lys Glu Val Gly Thr Pro His Gly Ile Ile Leu Asp Ser 
                325                 330                 335     


Val Asp Ala Ala Phe Ile Cys Pro Gly Ser Ser Arg Leu His Ile Met 
            340                 345                 350         


Ala Gly Arg Arg Leu Trp Trp Leu Asp Leu Lys Ser Gly Ala Gln Ala 
        355                 360                 365             


Thr Trp Thr Glu Leu Pro Trp Pro His Glu Lys Val Asp Gly Ala Leu 
    370                 375                 380                 


Cys Met Glu Lys Ser Leu Gly Pro Asn Ser Cys Ser Ala Asn Gly Pro 
385                 390                 395                 400 


Gly Leu Tyr Leu Ile His Gly Pro Asn Leu Tyr Cys Tyr Ser Asp Val 
                405                 410                 415     


Glu Lys Leu Asn Ala Ala Lys Ala Leu Pro Gln Pro Gln Asn Val Thr 
            420                 425                 430         


Ser Leu Leu Gly Cys Thr His 
        435                 


<210>  25
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  25

Lys Met Ala Ala Pro Met Glu Val Ala Val Cys Thr Asp Ser Ala Ala 
1               5                   10                  15      


Pro Met Trp Ser Cys Ile Val Trp Glu Leu His Ser Gly Ala Asn Leu 
            20                  25                  30          


Leu Thr Tyr Arg Gly Gly Gln Ala Gly Pro Arg Gly Leu Ala Leu Leu 
        35                  40                  45              


Asn Gly Glu Tyr Leu Leu Ala Ala Gln Leu Gly Lys Asn Tyr Ile Ser 
    50                  55                  60                  


Ala Trp Glu Leu Gln Arg Lys Asp Gln Leu Gln Gln Lys Ile Met Cys 
65                  70                  75                  80  


Pro Gly Pro Val Thr Cys Leu Thr Ala Ser Pro Asn Gly Leu Tyr Val 
                85                  90                  95      


Leu Ala Gly Val Ala Glu Ser Ile His Leu Trp Glu Val Ser Thr Gly 
            100                 105                 110         


Asn Leu Leu Val Ile Leu Ser Arg His Tyr Gln Asp Val Ser Cys Leu 
        115                 120                 125             


Gln Phe Thr Gly Asp Ser Ser His Phe Ile Ser Gly Gly Lys Asp Cys 
    130                 135                 140                 


Leu Val Leu Val Trp Ser Leu Cys Ser Val Leu Gln Ala Asp Pro Ser 
145                 150                 155                 160 


Arg Ile Pro Ala Pro Arg His Val Trp Ser His His Ala Leu Pro Ile 
                165                 170                 175     


Thr Asp Leu His Cys Gly Phe Gly Gly Pro Leu Ala Arg Val Ala Thr 
            180                 185                 190         


Ser Ser Leu Asp Gln Thr Leu Trp Glu Val Ser Ser Gly Glu Leu Leu 
        195                 200                 205             


Leu Ser Val Leu Phe Asp Val Ser Ile Met Ala Val Thr Met Asp Leu 
    210                 215                 220                 


Ala Glu His His Met Phe Cys Gly Gly Ser Glu Gly Ser Ile Phe Gln 
225                 230                 235                 240 


Val Asp Leu Phe Thr Trp Pro Gly Gln Arg Glu Arg Ser Phe His Pro 
                245                 250                 255     


Glu Gln Asp Ala Gly Lys Val Phe Lys Gly His Arg Asn Gln Val Thr 
            260                 265                 270         


Cys Leu Ser Val Ser Thr Asp Gly Ser Val Leu Leu Ser Gly Ser His 
        275                 280                 285             


Asp Glu Thr Val Arg Leu Trp Asp Val Gln Ser Lys Gln Cys Ile Arg 
    290                 295                 300                 


Thr Val Ala Leu Lys Gly Pro Val Thr Asn Ala Ala Ile Leu Leu Ala 
305                 310                 315                 320 


Pro Val Ser Met Leu Ser Ser Asp Phe Arg Pro Ser Leu Pro Leu Pro 
                325                 330                 335     


His Phe Asn Lys His Leu Leu Gly Ala Glu His Gly Asp Glu Pro Arg 
            340                 345                 350         


His Gly Gly Leu Thr Leu Arg Leu Gly Leu His Gln Gln Gly Ser Glu 
        355                 360                 365             


Pro Ser Tyr Leu Asp Arg Thr Glu Gln Leu Gln Ala Val Leu Cys Ser 
    370                 375                 380                 


Thr Met Glu Lys Ser Val Leu Gly Gly Gln Asp Gln Leu Arg Val Arg 
385                 390                 395                 400 


Val Thr Glu Leu Glu Asp Glu Val Arg Asn Leu Arg Lys Ile Asn Arg 
                405                 410                 415     


Asp Leu Phe Asp Phe Ser Thr Arg Phe Ile Thr Arg Pro Ala Lys 
            420                 425                 430     


<210>  26
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  26

Pro Ser Gly Lys Met Ala Ala Val Gln Ala Ala Glu Val Lys Val Asp 
1               5                   10                  15      


Gly Ser Glu Pro Lys Leu Ser Lys Asn Glu Leu Lys Arg Arg Leu Lys 
            20                  25                  30          


Ala Glu Lys Lys Val Ala Glu Lys Glu Ala Lys Gln Lys Glu Leu Ser 
        35                  40                  45              


Glu Lys Gln Leu Ser Gln Ala Thr Ala Ala Ala Thr Asn His Thr Thr 
    50                  55                  60                  


Asp Asn Gly Val Gly Pro Glu Glu Glu Ser Val Asp Pro Asn Gln Tyr 
65                  70                  75                  80  


Tyr Lys Ile Arg Ser Gln Ala Ile His Gln Leu Lys Val Asn Gly Glu 
                85                  90                  95      


Asp Pro Tyr Pro His Lys Phe His Val Asp Ile Ser Leu Thr Asp Phe 
            100                 105                 110         


Ile Gln Lys Tyr Ser His Leu Gln Pro Gly Asp His Leu Thr Asp Ile 
        115                 120                 125             


Thr Leu Lys Val Ala Gly Arg Ile His Ala Lys Arg Ala Ser Gly Gly 
    130                 135                 140                 


Lys Leu Ile Phe Tyr Asp Leu Arg Gly Glu Gly Val Lys Leu Gln Val 
145                 150                 155                 160 


Met Ala Asn Ser Arg Asn Tyr Lys Ser Glu Glu Glu Phe Ile His Ile 
                165                 170                 175     


Asn Asn Lys Leu Arg Arg Gly Asp Ile Ile Gly Val Gln Gly Asn Pro 
            180                 185                 190         


Gly Lys Thr Lys Lys Gly Glu Leu Ser Ile Ile Pro Tyr Glu Ile Thr 
        195                 200                 205             


Leu Leu Ser Pro Cys Leu His Met Leu Pro His Leu His Phe Gly Leu 
    210                 215                 220                 


Lys Asp Lys Glu Thr Arg Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Leu 
225                 230                 235                 240 


Asn Asp Phe Val Arg Gln Lys Phe Ile Ile Arg Ser Lys Ile Ile Thr 
                245                 250                 255     


Tyr Ile Arg Ser Phe Leu Asp Glu Leu Gly Phe Leu Glu Ile Glu Thr 
            260                 265                 270         


Pro Met Met Asn Ile Ile Pro Gly Gly Ala Val Ala Lys Pro Phe Ile 
        275                 280                 285             


Thr Tyr His Asn Glu Leu Asp Met Asn Leu Tyr Met Arg Ile Ala Pro 
    290                 295                 300                 


Glu Leu Tyr His Lys Met Leu Val Val Gly Gly Ile Asp Arg Val Tyr 
305                 310                 315                 320 


Glu Ile Gly Arg Gln Phe Arg Asn Glu Gly Ile Asp Leu Thr His Asn 
                325                 330                 335     


Pro Glu Phe Thr Thr Cys Glu Phe Tyr Met Ala Tyr Ala Asp Tyr His 
            340                 345                 350         


Asp Leu Met Glu Ile Thr Glu Lys Met Val Ser Gly Met Val Lys His 
        355                 360                 365             


Ile Thr Gly Ser Tyr Lys Val Thr Tyr His Pro Asp Gly Pro Glu Gly 
    370                 375                 380                 


Gln Ala Tyr Asp Val Asp Phe Thr Pro Pro Phe Arg Arg Ile Asn Met 
385                 390                 395                 400 


Val Glu Glu Leu Glu Lys Ala Leu Gly Met Lys Leu Pro Glu Thr Asn 
                405                 410                 415     


Leu Phe Glu Thr Glu Glu Thr Arg Lys Ile Leu Asp Asp Ile Cys Val 
            420                 425                 430         


Ala Lys Ala Val Glu Cys Pro Pro Pro Arg Thr Thr Ala Arg Leu Leu 
        435                 440                 445             


Asp Lys Leu Val Gly Glu Phe Leu Glu Val Thr Cys Ile Asn Pro Thr 
    450                 455                 460                 


Phe Ile Cys Asp His Pro Gln Ile Met Ser Pro Leu Ala Lys Trp His 
465                 470                 475                 480 


Arg Ser Lys Glu Gly Leu Thr Glu Arg Phe Glu Leu Phe Val Met Lys 
                485                 490                 495     


Lys Glu Ile Cys Asn Ala Tyr Thr Glu Leu Asn Asp Pro Met Arg Gln 
            500                 505                 510         


Arg Gln Leu Phe Glu Glu Gln Ala Lys Ala Lys Ala Ala Gly Asp Asp 
        515                 520                 525             


Glu Ala Met Phe Ile Asp Glu Asn Phe Cys Thr Ala Leu Glu Tyr Gly 
    530                 535                 540                 


Leu Pro Pro Thr Ala Gly Trp Gly Met Gly Ile Asp Arg Val Ala Met 
545                 550                 555                 560 


Phe Leu Thr Asp Ser Asn Asn Ile Lys Glu Val Leu Leu Phe Pro Ala 
                565                 570                 575     


Met Lys Pro Glu Asp Lys Lys Glu Asn Val Ala Thr Thr Asp Thr Leu 
            580                 585                 590         


Glu Ser Thr Thr Val Gly Ser Ser Val 
        595                 600     


