
                                SEQUENCE LISTING

<110> Mayo Foundation for Medical Education and Research
      University of Iowa Research Foundation

<120> LONG ACTING ATRIAL NATRIURETIC PEPTIDE
  (LA-ANP) AND METHODS FOR USE THEREOF
  

<130> 07039/0945WO1

<150> 61/224,303          
<151> 2009-07-09  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 16
<212> DNA
<213> Homo sapiens

<400> 1
agtaccgaag ataaca                                                 16

<210> 2
<211> 16
<212> DNA
<213> Homo sapiens

<400> 2
agtactgaag ataaca                                                 16

<210> 3
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3
Tyr Arg Ile Thr Ala Arg Glu Asp Lys Gln Gly Trp Ala
 1               5                  10              


<210> 4
<211> 46
<212> DNA
<213> Homo sapiens

<400> 4
agtaccggat aacagccagg gaggacacgc agggctgggc ctaggg                46

<210> 5
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr
            20                  25              


<210> 6
<211> 40
<212> PRT
<213> Homo sapiens

<400> 6
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 7
<211> 28
<212> PRT
<213> Oryctolagus cuniculus

<400> 7
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Ile Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr
            20                  25              


<210> 8
<211> 28
<212> PRT
<213> Danio rerio

<400> 8
Ser Lys Ser Leu Ser Gly Cys Phe Gly Gly Arg Leu Asp Arg Ile Gly
 1               5                  10                  15      
Ser Ser Ser Thr Leu Gly Cys Asn Ser Lys Lys Gly
            20                  25              


<210> 9
<211> 32
<212> PRT
<213> Homo sapiens

<400> 9
Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp
 1               5                  10                  15      
Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His
            20                  25                  30          


<210> 10
<211> 22
<212> PRT
<213> Homo sapiens

<400> 10
Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser
 1               5                  10                  15      
Met Ser Gly Leu Gly Cys
            20          


<210> 11
<211> 38
<212> PRT
<213> Dendroaspis angusticeps

<400> 11
Glu Val Lys Tyr Asp Pro Cys Phe Gly His Lys Ile Asp Arg Ile Asn
 1               5                  10                  15      
His Val Ser Asn Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn
            20                  25                  30          
Ala Pro Ser Thr Ser Ala
        35              


<210> 12
<211> 32
<212> PRT
<213> Homo sapiens

<400> 12
Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met
 1               5                  10                  15      
Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr
            20                  25                  30          


<210> 13
<211> 12
<212> PRT
<213> Homo sapiens

<400> 13
Arg Ile Thr Ala Arg Glu Asp Lys Gln Gly Trp Ala
 1               5                  10          


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus

<220> 
<221> VARIANT        
<222> 4
<223> Xaa= Gly, Arg, Leu, or His

<220> 
<221> VARIANT        
<222> 5
<223> Xaa= Arg or Lys

<220> 
<221> VARIANT        
<222> 6
<223> Xaa= Met, Leu, or Ile

<220> 
<221> VARIANT        
<222> 10
<223> Xaa= Gly, Ser, or Asn

<220> 
<221> VARIANT        
<222> 11
<223> Xaa= Ala, Ser, or His

<220> 
<221> VARIANT        
<222> 12
<223> Xaa=Gln, Ser, Met, or Val

<220> 
<221> VARIANT        
<222> 14
<223> Xaa= Gly, Thr, or Asn

<400> 14
Cys Phe Gly Xaa Xaa Xaa Asp Arg Ile Xaa Xaa Xaa Ser Xaa Leu Gly
 1               5                  10                  15      
Cys
    


<210> 15
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 15
Thr Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 16
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 16
Ser Ile Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 17
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 17
Ser Leu Lys Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 18
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 18
Ser Leu Arg Lys Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 19
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 19
Ser Leu Arg Arg Thr Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Ala
        35                  40  


<210> 20
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 20
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Arg Gln Gly Trp Ala
        35                  40  


<210> 21
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 21
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Asn Gly Trp Ala
        35                  40  


<210> 22
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 22
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Pro Trp Ala
        35                  40  


<210> 23
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 23
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Tyr Ala
        35                  40  


<210> 24
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 24
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly
 1               5                  10                  15      
Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Arg Ile Thr Ala
            20                  25                  30          
Arg Glu Asp Lys Gln Gly Trp Val
        35                  40  


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 25
ggagacaggg acagacgtag                                             20

<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 26
cccagactgc acccgctttc                                             20

<210> 27
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 27
gccaggaaag cgggtgcag                                              19

<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 28
gggcactctg ggtgttggg                                              19

<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 29
gtgggaagca ggtggtcagt a                                           21

<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 30
agcttagatg ggatgatcac a                                           21

<210> 31
<211> 14
<212> PRT
<213> Homo sapiens

<400> 31
Cys Tyr Arg Ile Thr Ala Arg Glu Asp Lys Gln Gly Trp Ala
 1               5                  10                  

