                               SEQUENCE LISTING	

<110> GENENTECH, INC.
 
<120> DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DEMYELINATING DISEASES

<130> GNE-0352 PCT

<140>
<141>

<150> 61/223,511
<151> 2009-07-07

<160> 2     

<170> PatentIn version 3.5


<210> 1
<211> 290
<212> PRT
<213> Mus musculus

<400> 1
Met His Leu Ser Leu Leu Val Pro Phe Leu Phe Trp Ile Thr Gly Cys 
1               5                   10                  15      


Cys Thr Ala Glu Asp Pro Val Thr Gly Pro Glu Glu Val Ser Gly Gln 
            20                  25                  30          

Glu Gln Gly Ser Leu Thr Val Gln Cys Arg Tyr Thr Ser Gly Trp Lys 
        35                  40                  45              


Asp Tyr Lys Lys Tyr Trp Cys Gln Gly Val Pro Gln Arg Ser Cys Lys 
    50                  55                  60                  


Thr Leu Val Glu Thr Asp Ala Ser Glu Gln Leu Val Lys Lys Asn Arg 
65                  70                  75                  80  


Val Ser Ile Arg Asp Asn Gln Arg Asp Phe Ile Phe Thr Val Thr Met 
                85                  90                  95      


Glu Asp Leu Arg Met Ser Asp Ala Gly Ile Tyr Trp Cys Gly Ile Thr 
            100                 105                 110         


Lys Gly Gly Leu Asp Pro Met Phe Lys Val Thr Val Asn Ile Gly Pro 
        115                 120                 125             


Ala Ile Gln Val Pro Ile Thr Val Pro Thr Met Pro Pro Ile Thr Ser 
    130                 135                 140                 


Thr Thr Thr Ile Phe Thr Val Thr Thr Thr Val Lys Glu Thr Ser Met 
145                 150                 155                 160 


Phe Pro Thr Leu Thr Ser Tyr Tyr Ser Asp Asn Gly His Gly Gly Gly 
                165                 170                 175     


Asp Ser Gly Gly Gly Glu Asp Gly Val Gly Asp Gly Phe Leu Asp Leu 
            180                 185                 190         


Ser Val Leu Leu Pro Val Ile Ser Ala Val Leu Leu Leu Leu Leu Leu 
        195                 200                 205             


Val Ala Ser Leu Phe Ala Trp Arg Met Val Arg Arg Gln Lys Lys Ala 
    210                 215                 220                 


Ala Gly Pro Pro Ser Glu Gln Ala Gln Ser Leu Glu Gly Asp Leu Cys 
225                 230                 235                 240 


Tyr Ala Asp Leu Ser Leu Lys Gln Pro Arg Thr Ser Pro Gly Ser Ser 
                245                 250                 255     


Trp Lys Lys Gly Ser Ser Met Ser Ser Ser Gly Lys Asp His Gln Glu 
            260                 265                 270         


Glu Val Glu Tyr Val Thr Met Ala Pro Phe Pro Arg Glu Glu Val Ser 
        275                 280                 285             


Tyr Ala Ala Leu Thr Leu Ala Gly Leu Gly Gln Glu Pro Thr Tyr Gly 
    290                 295                 300                 


Asn Thr Gly Cys Pro Ile Thr His Val Pro Arg Thr Gly Leu Glu Glu 
305                 310                 315                 320 


Glu Thr Thr Glu Tyr Ser Ser Ile Arg Arg Pro Leu Pro Ala Ala Met 
                325                 330                 335     


Pro 
    


<210> 2
<211> 337
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Ala Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Arg Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 

