                         SEQUENCE LISTING

<110>  Lee, Kelvin
 
<120>  PRODRUG ANTI-CANCER THERAPY

<130>  003551.00357

<150>  US 61/219,220
<151>  2009-06-22

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  human

<400>  1

Arg Phe Ala Arg Lys Gly Ala Lys Arg Gln Lys Asn Val 
1               5                   10              


<210>  2
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  engineered kinase motif

<400>  2

Ala Arg Lys Ile Tyr Lys Arg Pro 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  engineered kinase target motif

<400>  3

Ala Arg Lys Ile Tyr Lys Arg Phe 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  engineered kinase target motif

<400>  4

Ala Arg Lys Ile Tyr Lys Arg Thr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  engineered kinase target motif

<400>  5

Ala Arg Lys Ser Tyr Lys Arg Phe 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Abl kinase target motif concensus sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Ala Xaa Xaa Ile Tyr Xaa Xaa Xaa 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  HIV

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  8
<211>  674
<212>  PRT
<213>  human

<400>  8

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala 
        


<210>  9
<211>  920
<212>  PRT
<213>  artificial

<220>
<223>  PKC Beta II GFP fusion

<400>  9

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        675                 680                 685             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    690                 695                 700                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
705                 710                 715                 720 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                725                 730                 735     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            740                 745                 750         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        755                 760                 765             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    770                 775                 780                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
785                 790                 795                 800 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                805                 810                 815     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            820                 825                 830         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        835                 840                 845             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    850                 855                 860                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
865                 870                 875                 880 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                885                 890                 895     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            900                 905                 910         


Leu Gly Met Asp Glu Leu Tyr Lys 
        915                 920 


<210>  10
<211>  920
<212>  PRT
<213>  artificial sequence

<220>
<223>  PKC Beta II GFP A1-2 fusion protein

<400>  10

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Pro Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        675                 680                 685             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    690                 695                 700                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
705                 710                 715                 720 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                725                 730                 735     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            740                 745                 750         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        755                 760                 765             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    770                 775                 780                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
785                 790                 795                 800 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                805                 810                 815     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            820                 825                 830         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        835                 840                 845             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    850                 855                 860                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
865                 870                 875                 880 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                885                 890                 895     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            900                 905                 910         


Leu Gly Met Asp Glu Leu Tyr Lys 
        915                 920 


<210>  11
<211>  920
<212>  PRT
<213>  artificial sequence

<220>
<223>  PKC Beta II GFP A2-1 fusion protein

<400>  11

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Phe Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        675                 680                 685             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    690                 695                 700                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
705                 710                 715                 720 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                725                 730                 735     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            740                 745                 750         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        755                 760                 765             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    770                 775                 780                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
785                 790                 795                 800 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                805                 810                 815     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            820                 825                 830         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        835                 840                 845             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    850                 855                 860                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
865                 870                 875                 880 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                885                 890                 895     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            900                 905                 910         


Leu Gly Met Asp Glu Leu Tyr Lys 
        915                 920 


<210>  12
<211>  920
<212>  PRT
<213>  artificial sequence

<220>
<223>  PKC Beta II GFP A3-4 fusion protein

<400>  12

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Thr Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        675                 680                 685             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    690                 695                 700                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
705                 710                 715                 720 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                725                 730                 735     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            740                 745                 750         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        755                 760                 765             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    770                 775                 780                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
785                 790                 795                 800 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                805                 810                 815     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            820                 825                 830         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        835                 840                 845             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    850                 855                 860                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
865                 870                 875                 880 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                885                 890                 895     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            900                 905                 910         


Leu Gly Met Asp Glu Leu Tyr Lys 
        915                 920 


<210>  13
<211>  920
<212>  PRT
<213>  artificial sequence

<220>
<223>  PKC Beta II GFP A4-6 fusion protein

<400>  13

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Ser Tyr Leu Arg Phe Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        675                 680                 685             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    690                 695                 700                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
705                 710                 715                 720 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                725                 730                 735     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            740                 745                 750         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        755                 760                 765             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    770                 775                 780                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
785                 790                 795                 800 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                805                 810                 815     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            820                 825                 830         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        835                 840                 845             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    850                 855                 860                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
865                 870                 875                 880 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                885                 890                 895     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            900                 905                 910         


Leu Gly Met Asp Glu Leu Tyr Lys 
        915                 920 


<210>  14
<211>  1002
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAT-PKC Beta II GFP fusion protein

<400>  14

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Lys Met Ala Asp Pro 
65                  70                  75                  80  


Ala Ala Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu 
                85                  90                  95      


Glu Ser Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn 
            100                 105                 110         


Val His Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln 
        115                 120                 125             


Pro Thr Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys 
    130                 135                 140                 


Gln Gly Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys 
145                 150                 155                 160 


His Glu Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala 
                165                 170                 175     


Ser Asp Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser 
            180                 185                 190         


Ser Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile 
        195                 200                 205             


His Gln Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg 
    210                 215                 220                 


Cys Val Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg 
225                 230                 235                 240 


Arg Gly Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile 
                245                 250                 255     


Val Leu Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly 
            260                 265                 270         


Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser 
        275                 280                 285             


Glu Ser Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu 
    290                 295                 300                 


Trp Asn Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg 
305                 310                 315                 320 


Arg Leu Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp 
                325                 330                 335     


Phe Met Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser 
            340                 345                 350         


Val Asp Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe 
        355                 360                 365             


Asn Val Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg 
    370                 375                 380                 


Gln Lys Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg 
                405                 410                 415     


Asp Arg Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys 
            420                 425                 430         


Gly Ser Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp 
    450                 455                 460                 


Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Thr Met Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Asn 
                485                 490                 495     


Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Arg Phe Lys Glu 
            500                 505                 510         


Pro His Ala Val Phe Tyr Ala Ala Glu Ile Pro Phe Leu Thr Gln Leu 
        515                 520                 525             


His Ser Cys Phe Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile 
    530                 535                 540                 


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly 
545                 550                 555                 560 


His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp 
                565                 570                 575     


Gly Val Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
            580                 585                 590         


Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala 
        595                 600                 605             


Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val 
625                 630                 635                 640 


Ala Tyr Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly 
                645                 650                 655     


Leu Met Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly 
            660                 665                 670         


Glu Arg Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu 
        675                 680                 685             


Lys Leu Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys 
    690                 695                 700                 


Gly Arg Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro 
705                 710                 715                 720 


Val Leu Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser 
                725                 730                 735     


Glu Phe Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu 
            740                 745                 750         


Val Lys Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr Leu Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


<210>  15
<211>  1002
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAT-PKC Beta II GFP A1-2 fusion protein

<400>  15

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Lys Met Ala Asp Pro 
65                  70                  75                  80  


Ala Ala Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu 
                85                  90                  95      


Glu Ser Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Pro Lys Asn 
            100                 105                 110         


Val His Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln 
        115                 120                 125             


Pro Thr Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys 
    130                 135                 140                 


Gln Gly Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys 
145                 150                 155                 160 


His Glu Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala 
                165                 170                 175     


Ser Asp Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser 
            180                 185                 190         


Ser Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile 
        195                 200                 205             


His Gln Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg 
    210                 215                 220                 


Cys Val Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg 
225                 230                 235                 240 


Arg Gly Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile 
                245                 250                 255     


Val Leu Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly 
            260                 265                 270         


Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser 
        275                 280                 285             


Glu Ser Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu 
    290                 295                 300                 


Trp Asn Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg 
305                 310                 315                 320 


Arg Leu Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp 
                325                 330                 335     


Phe Met Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser 
            340                 345                 350         


Val Asp Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe 
        355                 360                 365             


Asn Val Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg 
    370                 375                 380                 


Gln Lys Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg 
                405                 410                 415     


Asp Arg Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys 
            420                 425                 430         


Gly Ser Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp 
    450                 455                 460                 


Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Thr Met Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Asn 
                485                 490                 495     


Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Arg Phe Lys Glu 
            500                 505                 510         


Pro His Ala Val Phe Tyr Ala Ala Glu Ile Pro Phe Leu Thr Gln Leu 
        515                 520                 525             


His Ser Cys Phe Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile 
    530                 535                 540                 


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly 
545                 550                 555                 560 


His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp 
                565                 570                 575     


Gly Val Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
            580                 585                 590         


Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala 
        595                 600                 605             


Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val 
625                 630                 635                 640 


Ala Tyr Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly 
                645                 650                 655     


Leu Met Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly 
            660                 665                 670         


Glu Arg Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu 
        675                 680                 685             


Lys Leu Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys 
    690                 695                 700                 


Gly Arg Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro 
705                 710                 715                 720 


Val Leu Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser 
                725                 730                 735     


Glu Phe Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu 
            740                 745                 750         


Val Lys Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr Leu Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


<210>  16
<211>  1002
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAT-PKC Beta II GFP A2-1 fusion protein

<400>  16

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Lys Met Ala Asp Pro 
65                  70                  75                  80  


Ala Ala Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu 
                85                  90                  95      


Glu Ser Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Phe Lys Asn 
            100                 105                 110         


Val His Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln 
        115                 120                 125             


Pro Thr Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys 
    130                 135                 140                 


Gln Gly Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys 
145                 150                 155                 160 


His Glu Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala 
                165                 170                 175     


Ser Asp Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser 
            180                 185                 190         


Ser Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile 
        195                 200                 205             


His Gln Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg 
    210                 215                 220                 


Cys Val Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg 
225                 230                 235                 240 


Arg Gly Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile 
                245                 250                 255     


Val Leu Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly 
            260                 265                 270         


Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser 
        275                 280                 285             


Glu Ser Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu 
    290                 295                 300                 


Trp Asn Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg 
305                 310                 315                 320 


Arg Leu Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp 
                325                 330                 335     


Phe Met Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser 
            340                 345                 350         


Val Asp Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe 
        355                 360                 365             


Asn Val Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg 
    370                 375                 380                 


Gln Lys Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg 
                405                 410                 415     


Asp Arg Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys 
            420                 425                 430         


Gly Ser Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp 
    450                 455                 460                 


Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Thr Met Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Asn 
                485                 490                 495     


Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Arg Phe Lys Glu 
            500                 505                 510         


Pro His Ala Val Phe Tyr Ala Ala Glu Ile Pro Phe Leu Thr Gln Leu 
        515                 520                 525             


His Ser Cys Phe Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile 
    530                 535                 540                 


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly 
545                 550                 555                 560 


His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp 
                565                 570                 575     


Gly Val Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
            580                 585                 590         


Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala 
        595                 600                 605             


Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val 
625                 630                 635                 640 


Ala Tyr Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly 
                645                 650                 655     


Leu Met Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly 
            660                 665                 670         


Glu Arg Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu 
        675                 680                 685             


Lys Leu Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys 
    690                 695                 700                 


Gly Arg Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro 
705                 710                 715                 720 


Val Leu Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser 
                725                 730                 735     


Glu Phe Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu 
            740                 745                 750         


Val Lys Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr Leu Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


<210>  17
<211>  1002
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAT-PKC Beta II GFP A3-4 fusion protein

<400>  17

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Lys Met Ala Asp Pro 
65                  70                  75                  80  


Ala Ala Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu 
                85                  90                  95      


Glu Ser Thr Val Arg Phe Ala Arg Lys Ile Tyr Leu Arg Thr Lys Asn 
            100                 105                 110         


Val His Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln 
        115                 120                 125             


Pro Thr Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys 
    130                 135                 140                 


Gln Gly Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys 
145                 150                 155                 160 


His Glu Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala 
                165                 170                 175     


Ser Asp Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser 
            180                 185                 190         


Ser Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile 
        195                 200                 205             


His Gln Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg 
    210                 215                 220                 


Cys Val Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg 
225                 230                 235                 240 


Arg Gly Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile 
                245                 250                 255     


Val Leu Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly 
            260                 265                 270         


Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser 
        275                 280                 285             


Glu Ser Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu 
    290                 295                 300                 


Trp Asn Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg 
305                 310                 315                 320 


Arg Leu Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp 
                325                 330                 335     


Phe Met Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser 
            340                 345                 350         


Val Asp Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe 
        355                 360                 365             


Asn Val Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg 
    370                 375                 380                 


Gln Lys Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg 
                405                 410                 415     


Asp Arg Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys 
            420                 425                 430         


Gly Ser Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp 
    450                 455                 460                 


Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Thr Met Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Asn 
                485                 490                 495     


Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Arg Phe Lys Glu 
            500                 505                 510         


Pro His Ala Val Phe Tyr Ala Ala Glu Ile Pro Phe Leu Thr Gln Leu 
        515                 520                 525             


His Ser Cys Phe Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile 
    530                 535                 540                 


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly 
545                 550                 555                 560 


His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp 
                565                 570                 575     


Gly Val Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
            580                 585                 590         


Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala 
        595                 600                 605             


Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val 
625                 630                 635                 640 


Ala Tyr Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly 
                645                 650                 655     


Leu Met Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly 
            660                 665                 670         


Glu Arg Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu 
        675                 680                 685             


Lys Leu Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys 
    690                 695                 700                 


Gly Arg Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro 
705                 710                 715                 720 


Val Leu Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser 
                725                 730                 735     


Glu Phe Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu 
            740                 745                 750         


Val Lys Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr Leu Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


<210>  18
<211>  1002
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAT-PKC Beta II GFP A4-6 fusion protein

<400>  18

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Lys Met Ala Asp Pro 
65                  70                  75                  80  


Ala Ala Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu 
                85                  90                  95      


Glu Ser Thr Val Arg Phe Ala Arg Lys Ser Tyr Leu Arg Phe Lys Asn 
            100                 105                 110         


Val His Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln 
        115                 120                 125             


Pro Thr Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys 
    130                 135                 140                 


Gln Gly Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys 
145                 150                 155                 160 


His Glu Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala 
                165                 170                 175     


Ser Asp Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser 
            180                 185                 190         


Ser Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile 
        195                 200                 205             


His Gln Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg 
    210                 215                 220                 


Cys Val Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg 
225                 230                 235                 240 


Arg Gly Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile 
                245                 250                 255     


Val Leu Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly 
            260                 265                 270         


Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser 
        275                 280                 285             


Glu Ser Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu 
    290                 295                 300                 


Trp Asn Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg 
305                 310                 315                 320 


Arg Leu Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp 
                325                 330                 335     


Phe Met Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser 
            340                 345                 350         


Val Asp Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe 
        355                 360                 365             


Asn Val Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg 
    370                 375                 380                 


Gln Lys Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg 
                405                 410                 415     


Asp Arg Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys 
            420                 425                 430         


Gly Ser Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp 
    450                 455                 460                 


Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Thr Met Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Asn 
                485                 490                 495     


Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Arg Phe Lys Glu 
            500                 505                 510         


Pro His Ala Val Phe Tyr Ala Ala Glu Ile Pro Phe Leu Thr Gln Leu 
        515                 520                 525             


His Ser Cys Phe Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile 
    530                 535                 540                 


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly 
545                 550                 555                 560 


His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp 
                565                 570                 575     


Gly Val Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
            580                 585                 590         


Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala 
        595                 600                 605             


Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val 
625                 630                 635                 640 


Ala Tyr Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly 
                645                 650                 655     


Leu Met Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly 
            660                 665                 670         


Glu Arg Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu 
        675                 680                 685             


Lys Leu Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys 
    690                 695                 700                 


Gly Arg Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro 
705                 710                 715                 720 


Val Leu Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser 
                725                 730                 735     


Glu Phe Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu 
            740                 745                 750         


Val Lys Ser Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        755                 760                 765             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    770                 775                 780                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
785                 790                 795                 800 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                805                 810                 815     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            820                 825                 830         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        835                 840                 845             


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
    850                 855                 860                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
865                 870                 875                 880 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                885                 890                 895     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
            900                 905                 910         


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
        915                 920                 925             


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
    930                 935                 940                 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
945                 950                 955                 960 


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
                965                 970                 975     


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            980                 985                 990         


Ile Thr Leu Gly Met Asp Glu Leu  Tyr Lys 
        995                 1000         


