                         SEQUENCE LISTING

<110>  Chronos Therapeutics
 
<120>  Screening Method for Cell Ageing

<130>  P037286WO

<150>  GB 0911885.2
<151>  2009-07-08

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  824
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Met Asn Phe Phe Thr Ser Lys Ser Ser Asn Gln Asp Thr Gly Phe 
1               5                   10                  15      


Ser Ser Gln His Gln His Pro Asn Gly Gln Asn Asn Gly Asn Asn Asn 
            20                  25                  30          


Ser Ser Thr Ala Gly Asn Asp Asn Gly Tyr Pro Cys Lys Leu Val Ser 
        35                  40                  45              


Ser Gly Pro Cys Ala Ser Ser Asn Asn Gly Ala Leu Phe Thr Asn Phe 
    50                  55                  60                  


Thr Leu Gln Thr Ala Thr Pro Thr Thr Ala Ile Ser Gln Asp Leu Tyr 
65                  70                  75                  80  


Ala Met Gly Thr Thr Gly Ile Thr Ser Glu Asn Ala Leu Phe Gln Met 
                85                  90                  95      


Lys Ser Met Asn Asn Gly Ile Ser Ser Val Asn Asn Asn Asn Ser Asn 
            100                 105                 110         


Thr Pro Thr Ile Ile Thr Thr Ser Gln Glu Glu Thr Asn Ala Gly Asn 
        115                 120                 125             


Val His Gly Asp Thr Gly Gly Asn Ser Leu Gln Asn Ser Glu Asp Asp 
    130                 135                 140                 


Asn Phe Ser Ser Ser Ser Thr Thr Lys Cys Leu Leu Ser Ser Thr Ser 
145                 150                 155                 160 


Ser Leu Ser Ile Asn Gln Arg Glu Ala Ala Ala Ala Ala Tyr Gly Pro 
                165                 170                 175     


Asp Thr Asp Ile Pro Arg Gly Lys Leu Glu Val Thr Ile Ile Glu Ala 
            180                 185                 190         


Arg Asp Leu Val Thr Arg Ser Lys Asp Ser Gln Pro Tyr Val Val Cys 
        195                 200                 205             


Thr Phe Glu Ser Ser Glu Phe Ile Ser Asn Gly Pro Glu Ser Leu Gly 
    210                 215                 220                 


Ala Ile Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Gln His Asn Gln 
225                 230                 235                 240 


Asn Gln His Ile Asn Asn Asn Asn Glu Asn Thr Asn Pro Asp Ala Ala 
                245                 250                 255     


Ser Gln His His Asn Asn Asn Ser Gly Trp Asn Gly Ser Gln Leu Pro 
            260                 265                 270         


Ser Ile Lys Glu His Leu Lys Lys Lys Pro Leu Tyr Thr His Arg Ser 
        275                 280                 285             


Ser Ser Gln Leu Asp Gln Leu Asn Ser Cys Ser Ser Val Thr Asp Pro 
    290                 295                 300                 


Ser Lys Arg Ser Ser Asn Ser Ser Ser Gly Ser Ser Asn Gly Pro Lys 
305                 310                 315                 320 


Asn Asp Ser Ser His Pro Ile Trp His His Lys Thr Thr Phe Asp Val 
                325                 330                 335     


Leu Gly Ser His Ser Glu Leu Asp Ile Ser Val Tyr Asp Ala Ala His 
            340                 345                 350         


Asp His Met Phe Leu Gly Gln Val Arg Leu Tyr Pro Met Ile His Asn 
        355                 360                 365             


Leu Ala His Ala Ser Gln His Gln Trp His Ser Leu Lys Pro Arg Val 
    370                 375                 380                 


Ile Asp Glu Val Val Ser Gly Asp Ile Leu Ile Lys Trp Thr Tyr Lys 
385                 390                 395                 400 


Gln Thr Lys Lys Arg His Tyr Gly Pro Gln Asp Phe Glu Val Leu Arg 
                405                 410                 415     


Leu Leu Gly Lys Gly Thr Phe Gly Gln Val Tyr Gln Val Lys Lys Lys 
            420                 425                 430         


Asp Thr Gln Arg Ile Tyr Ala Met Lys Val Leu Ser Lys Lys Val Ile 
        435                 440                 445             


Val Lys Lys Asn Glu Ile Ala His Thr Ile Gly Glu Arg Asn Ile Leu 
    450                 455                 460                 


Val Thr Thr Ala Ser Lys Ser Ser Pro Phe Ile Val Gly Leu Lys Phe 
465                 470                 475                 480 


Ser Phe Gln Thr Pro Thr Asp Leu Tyr Leu Val Thr Asp Tyr Met Ser 
                485                 490                 495     


Gly Gly Glu Leu Phe Trp His Leu Gln Lys Glu Gly Arg Phe Ser Glu 
            500                 505                 510         


Asp Arg Ala Lys Phe Tyr Ile Ala Glu Leu Val Leu Ala Leu Glu His 
        515                 520                 525             


Leu His Asp Asn Asp Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
    530                 535                 540                 


Leu Leu Asp Ala Asn Gly Asn Ile Ala Leu Cys Asp Phe Gly Leu Ser 
545                 550                 555                 560 


Lys Ala Asp Leu Lys Asp Arg Thr Asn Thr Phe Cys Gly Thr Thr Glu 
                565                 570                 575     


Tyr Leu Ala Pro Glu Leu Leu Leu Asp Glu Thr Gly Tyr Thr Lys Met 
            580                 585                 590         


Val Asp Phe Trp Ser Leu Gly Val Leu Ile Phe Glu Met Cys Cys Gly 
        595                 600                 605             


Trp Ser Pro Phe Phe Ala Glu Asn Asn Gln Lys Met Tyr Gln Lys Ile 
    610                 615                 620                 


Ala Phe Gly Lys Val Lys Phe Pro Arg Asp Val Leu Ser Gln Glu Gly 
625                 630                 635                 640 


Arg Ser Phe Val Lys Gly Leu Leu Asn Arg Asn Pro Lys His Arg Leu 
                645                 650                 655     


Gly Ala Ile Asp Asp Gly Arg Glu Leu Arg Ala His Pro Phe Phe Ala 
            660                 665                 670         


Asp Ile Asp Trp Glu Ala Leu Lys Gln Lys Lys Ile Pro Pro Pro Phe 
        675                 680                 685             


Lys Pro His Leu Val Ser Glu Thr Asp Thr Ser Asn Phe Asp Pro Glu 
    690                 695                 700                 


Phe Thr Thr Ala Ser Thr Ser Tyr Met Asn Lys His Gln Pro Met Met 
705                 710                 715                 720 


Thr Ala Thr Pro Leu Ser Pro Ala Met Gln Ala Lys Phe Ala Gly Phe 
                725                 730                 735     


Thr Phe Val Asp Glu Ser Ala Ile Asp Glu His Val Asn Asn Asn Arg 
            740                 745                 750         


Lys Phe Leu Gln Asn Ser Tyr Phe Met Glu Pro Gly Ser Phe Ile Pro 
        755                 760                 765             


Gly Asn Pro Asn Leu Pro Pro Asp Glu Asp Val Ile Asp Asp Asp Gly 
    770                 775                 780                 


Asp Glu Asp Ile Asn Asp Gly Phe Asn Gln Glu Lys Asn Met Asn Asn 
785                 790                 795                 800 


Ser His Ser Gln Met Asp Phe Asp Gly Asp Gln His Met Asp Asp Glu 
                805                 810                 815     


Phe Val Ser Gly Arg Phe Glu Ile 
            820                 


<210>  2
<211>  2475
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  2
atgatgaatt tttttacatc aaaatcgtcg aatcaggata ctggatttag ctctcaacac       60

caacatccaa atggacagaa caatggaaac aataatagca gcaccgctgg caacgacaac      120

ggatacccat gtaaactggt gtccagtggg ccctgcgctt catcaaataa tggtgccctt      180

tttacgaatt ttactttaca aactgcaacg ccgaccaccg ctattagtca ggacttatat      240

gcaatgggca caacaggaat aacatcagaa aatgcccttt ttcaaatgaa gtcaatgaat      300

aatggaatat catcagttaa taataacaac agcaacaccc ctacgattat taccacgtca      360

caggaagaaa ctaatgctgg aaatgtacat ggcgataccg gtggcaattc tttgcaaaat      420

tctgaagatg acaacttttc ttccagttct accaccaaat gcttactctc ttccacttct      480

tcgctatcaa taaatcaacg agaagcagca gcagctgctt atggtccaga taccgatatt      540

cctaggggta aactagaagt tacaataata gaagcacgtg acctagtcac tagatcaaag      600

gattcacagc cttatgttgt ttgtactttt gagagttcag agttcatttc taatggtcct      660

gagtcactag gcgccattaa taataacaac aataacaaca acaataatca gcataatcaa      720

aaccagcata ttaacaacaa caacgaaaat accaaccctg acgctgctag ccagcatcat      780

aataataaca gtggttggaa cggttctcag ttaccatcga taaaagagca cttgaagaaa      840

aaaccccttt atacacacag atcatcttcc caattagatc agctaaactc ttgctcttca      900

gtaaccgatc cgagcaaacg ttcttctaat tcttcgtcgg gttcttcaaa tggtccaaag      960

aatgatagtt cacatccaat atggcatcac aagacaacgt ttgatgtttt gggatctcac     1020

tcggaattag atatttctgt ttatgatgct gcccacgacc atatgttctt aggccaagtt     1080

agactgtatc caatgattca taatttagca catgcttccc aacaccaatg gcacagtttg     1140

aaacctcgcg ttattgatga agttgtgtcc ggtgatattt taatcaaatg gacttacaaa     1200

cagacaaaga aaagacatta tggcccacaa gattttgaag ttcttcgatt attgggtaag     1260

ggtacttttg gccaagtcta ccaagttaag aagaaagaca ctcaaagaat ttatgcaatg     1320

aaagttctct ccaagaaagt tattgtcaag aaaaatgaga tcgcccacac aattggcgaa     1380

agaaatatcc tagtcacgac agcgtccaaa tcgtccccat tcattgtcgg attgaagttt     1440

tcctttcaaa caccaacaga tctgtatttg gtcactgatt atatgagtgg tggagaatta     1500

ttctggcatt tacaaaagga gggccgtttt tcggaagaca gagcgaaatt ctatatcgct     1560

gagttagtcc tagcgttaga acatttacac gataacgata tcgtttacag ggacctaaag     1620

cctgaaaaca ttctactcga tgccaacggt aacatcgctc tttgcgattt tggtctttct     1680

aaagctgact tgaaggatag aacaaacaca ttttgcggca ccacggaata cctggcacca     1740

gaattgttac tggacgaaac cggctacacc aaaatggtcg atttctggtc tctaggtgtt     1800

ttgatatttg aaatgtgttg tggttggtcc cctttctttg cggaaaataa tcaaaaaatg     1860

taccaaaaaa ttgcctttgg taaagtcaaa ttccccagag acgtactgtc acaagagggg     1920

aggtcttttg taaagggttt actaaacaga aaccccaaac atagactcgg tgccattgat     1980

gatggaagag aactacgagc tcatccattt ttcgcagata tcgactggga ggccttgaag     2040

cagaaaaaaa ttccaccacc tttcaaacct cacctagtct cggagacgga tacctcgaat     2100

tttgacccag agttcacaac agcttcaact tcatacatga acaagcacca gccgatgatg     2160

actgctaccc cgctatctcc agccatgcaa gcaaagtttg ctggtttcac ctttgttgat     2220

gagtccgcca tcgatgaaca cgttaataac aacagaaaat tcctacaaaa ctcgtacttt     2280

atggaacctg gttcctttat cccgggaaat ccaaacttac ctccagacga agatgtcatc     2340

gatgatgacg gggacgagga catcaatgat ggattcaacc aagagaaaaa tatgaacaac     2400

agccattcgc agatggactt cgacggcgac caacacatgg atgacgaatt tgtcagtgga     2460

agattcgaaa tatga                                                      2475


<210>  3
<211>  588
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Ser Thr Leu Ser Asp Ser Asp Thr Glu Thr Glu Val Val Ser Arg 
1               5                   10                  15      


Asn Leu Cys Gly Ile Val Asp Ile Gly Ser Asn Gly Ile Arg Phe Ser 
            20                  25                  30          


Ile Ser Ser Lys Ala Ala His His Ala Arg Ile Met Pro Cys Val Phe 
        35                  40                  45              


Lys Asp Arg Val Gly Leu Ser Leu Tyr Glu Val Gln Tyr Asn Thr His 
    50                  55                  60                  


Thr Asn Ala Lys Cys Pro Ile Pro Arg Asp Ile Ile Lys Glu Val Cys 
65                  70                  75                  80  


Ser Ala Met Lys Arg Phe Lys Leu Ile Cys Asp Asp Phe Gly Val Pro 
                85                  90                  95      


Glu Thr Ser Val Arg Val Ile Ala Thr Glu Ala Thr Arg Asp Ala Ile 
            100                 105                 110         


Asn Ala Asp Glu Phe Val Asn Ala Val Tyr Gly Ser Thr Gly Trp Lys 
        115                 120                 125             


Val Glu Ile Leu Gly Gln Glu Asp Glu Thr Arg Val Gly Ile Tyr Gly 
    130                 135                 140                 


Val Val Ser Ser Phe Asn Thr Val Arg Gly Leu Tyr Leu Asp Val Ala 
145                 150                 155                 160 


Gly Gly Ser Thr Gln Leu Ser Trp Val Ile Ser Ser His Gly Glu Val 
                165                 170                 175     


Lys Gln Ser Ser Lys Pro Val Ser Leu Pro Tyr Gly Ala Gly Thr Leu 
            180                 185                 190         


Leu Arg Arg Met Arg Thr Asp Asp Asn Arg Ala Leu Phe Tyr Glu Ile 
        195                 200                 205             


Lys Glu Ala Tyr Lys Asp Ala Ile Glu Lys Ile Gly Ile Pro Gln Glu 
    210                 215                 220                 


Met Ile Asp Asp Ala Lys Lys Glu Gly Gly Phe Asp Leu Trp Thr Arg 
225                 230                 235                 240 


Gly Gly Gly Leu Arg Gly Met Gly His Leu Leu Leu Tyr Gln Ser Glu 
                245                 250                 255     


Gly Tyr Pro Ile Gln Thr Ile Ile Asn Gly Tyr Ala Cys Thr Tyr Glu 
            260                 265                 270         


Glu Phe Ser Ser Met Ser Asp Tyr Leu Phe Leu Lys Gln Lys Ile Pro 
        275                 280                 285             


Gly Ser Ser Lys Glu His Lys Ile Phe Lys Val Ser Asp Arg Arg Ala 
    290                 295                 300                 


Leu Gln Leu Pro Ala Val Gly Leu Phe Met Ser Ala Val Phe Glu Ala 
305                 310                 315                 320 


Ile Pro Gln Ile Lys Ala Val His Phe Ser Glu Gly Gly Val Arg Glu 
                325                 330                 335     


Gly Ser Leu Tyr Ser Leu Leu Pro Lys Glu Ile Arg Ala Gln Asp Pro 
            340                 345                 350         


Leu Leu Ile Ala Ser Arg Pro Tyr Ala Pro Leu Leu Thr Glu Lys Tyr 
        355                 360                 365             


Leu Tyr Leu Leu Arg Thr Ser Ile Pro Gln Glu Asp Ile Pro Glu Ile 
    370                 375                 380                 


Val Asn Glu Arg Ile Ala Pro Ala Leu Cys Asn Leu Ala Phe Val His 
385                 390                 395                 400 


Ala Ser Tyr Pro Lys Glu Leu Gln Pro Thr Ala Ala Leu His Val Ala 
                405                 410                 415     


Thr Arg Gly Ile Ile Ala Gly Cys His Gly Leu Ser His Arg Ala Arg 
            420                 425                 430         


Ala Leu Ile Gly Ile Ala Leu Cys Ser Arg Trp Gly Gly Asn Ile Pro 
        435                 440                 445             


Glu Ser Glu Glu Lys Tyr Ser Gln Glu Leu Glu Gln Val Val Leu Arg 
    450                 455                 460                 


Glu Gly Asp Lys Ala Glu Ala Leu Arg Ile Val Trp Trp Thr Lys Tyr 
465                 470                 475                 480 


Ile Gly Thr Ile Met Tyr Val Ile Cys Gly Val His Pro Gly Gly Asn 
                485                 490                 495     


Ile Arg Asp Asn Val Phe Asp Phe His Val Ser Lys Arg Ser Glu Val 
            500                 505                 510         


Glu Thr Ser Leu Lys Glu Leu Ile Ile Asp Asp Ala Asn Thr Thr Lys 
        515                 520                 525             


Val Lys Glu Glu Ser Thr Arg Lys Asn Arg Gly Tyr Glu Val Val Val 
    530                 535                 540                 


Arg Ile Ser Lys Asp Asp Leu Lys Thr Ser Ala Ser Val Arg Ser Arg 
545                 550                 555                 560 


Ile Ile Thr Leu Gln Lys Lys Val Arg Lys Leu Ser Arg Gly Ser Val 
                565                 570                 575     


Glu Arg Val Lys Ile Gly Val Gln Phe Tyr Glu Glu 
            580                 585             


<210>  4
<211>  1767
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  4
atgtcaacac ttagcgatag tgataccgag actgaggtcg tgtcgagaaa cttgtgtgga       60

atcgtcgaca taggttctaa tggtattcgt tttagtatat cttccaaggc tgcacatcat      120

gcaagaatta tgccttgtgt ttttaaagat agggttggtc tttctctata cgaagttcaa      180

tataatacac atacgaacgc aaaatgccct attcccagag atattataaa agaggtttgt      240

tctgccatga agagattcaa attaatttgc gatgattttg gtgtacctga aactagtgtc      300

agagtaattg caacagaagc cacgcgagat gctattaacg cggatgaatt tgttaatgct      360

gtttacggta gcactggctg gaaagtagaa atattaggcc aggaagatga aactagggtc      420

ggcatatatg gtgttgtttc ctcatttaat acagtaagag gtctatatct agatgtggca      480

ggtggtagta ctcagttatc atgggtaata agctcgcacg gagaagtcaa gcaatccagc      540

aaacctgtat ctttgccata tggagctgga actcttttga gaagaatgag aacagatgat      600

aatagggcac ttttttatga gattaaagaa gcgtacaaag atgcgattga aaaaattggt      660

atacctcaag aaatgattga tgacgccaag aaagaaggtg gatttgacct ttggacccgt      720

gggggtggtt taagaggtat gggacatctg cttctttacc agtcggaagg ttatcccatc      780

caaacaataa ttaacggata tgcttgcact tatgaagaat tctcgtctat gtcagattat      840

ctattcctaa aacaaaaaat accaggttct tcaaaagagc ataaaatatt taaggtttct      900

gatagaaggg ctttacaact tcctgccgtt ggtttgttca tgagtgctgt ttttgaagcg      960

attccccaga tcaaagctgt acattttagt gagggtggtg ttcgagaggg ttcactttat     1020

tctcttcttc caaaagaaat tcgtgcacaa gatccattgc taattgcgtc ccgtccttat     1080

gctccattac ttactgaaaa atatctatat ctattgagaa catcaatccc acaagaagat     1140

ataccagaaa tagtaaacga aaggattgct cctgctttat gtaacttagc atttgttcat     1200

gcctcttatc caaaggagtt acaaccaaca gctgcattac atgttgctac aagagggata     1260

atagccggct gtcatggatt atctcacaga gctagagcgc tgataggaat tgctctatgt     1320

agtagatggg gcggcaacat tccggaatct gaagaaaaat actcccaaga attagaacaa     1380

gtagttctac gcgaaggtga taaagctgaa gcattgagaa ttgtatggtg gacgaagtat     1440

attggtacga ttatgtatgt gatttgcggt gttcatccag gtggtaatat cagagataac     1500

gtatttgatt tccatgtttc taagcgtagt gaggtggaga ccagtttaaa agaattaatc     1560

attgatgatg caaacactac aaaggtaaaa gaagaatcca cgcgtaaaaa tcgcgggtat     1620

gaagtggttg tgagaattag taaggacgat cttaaaacaa gtgcttccgt tcgttccaga     1680

attatcacgc tacaaaagaa agtacgcaag ctatctagag gaagtgtaga gagggttaaa     1740

attggcgtgc aattttatga agaataa                                         1767


<210>  5
<211>  439
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Val Thr Lys His Gln Ile Glu Glu Asp His Leu Asp Gly Ala Thr 
1               5                   10                  15      


Thr Asp Pro Glu Val Lys Arg Val Lys Leu Glu Asn Asn Val Glu Glu 
            20                  25                  30          


Ile Gln Pro Glu Gln Ala Glu Thr Asn Lys Gln Glu Gly Thr Asp Lys 
        35                  40                  45              


Glu Asn Lys Gly Lys Phe Glu Lys Glu Thr Glu Arg Ile Gly Gly Ser 
    50                  55                  60                  


Glu Val Val Thr Asp Val Glu Lys Gly Ile Val Lys Phe Glu Phe Asp 
65                  70                  75                  80  


Gly Val Glu Tyr Thr Phe Lys Glu Arg Pro Ser Val Val Glu Glu Asn 
                85                  90                  95      


Glu Gly Lys Ile Glu Phe Arg Val Val Asn Asn Asp Asn Thr Lys Glu 
            100                 105                 110         


Asn Met Met Val Leu Thr Gly Leu Lys Asn Ile Phe Gln Lys Gln Leu 
        115                 120                 125             


Pro Lys Met Pro Lys Glu Tyr Ile Ala Arg Leu Val Tyr Asp Arg Ser 
    130                 135                 140                 


His Leu Ser Met Ala Val Ile Arg Lys Pro Leu Thr Val Val Gly Gly 
145                 150                 155                 160 


Ile Thr Tyr Arg Pro Phe Asp Lys Arg Glu Phe Ala Glu Ile Val Phe 
                165                 170                 175     


Cys Ala Ile Ser Ser Thr Glu Gln Val Arg Gly Tyr Gly Ala His Leu 
            180                 185                 190         


Met Asn His Leu Lys Asp Tyr Val Arg Asn Thr Ser Asn Ile Lys Tyr 
        195                 200                 205             


Phe Leu Thr Tyr Ala Asp Asn Tyr Ala Ile Gly Tyr Phe Lys Lys Gln 
    210                 215                 220                 


Gly Phe Thr Lys Glu Ile Thr Leu Asp Lys Ser Ile Trp Met Gly Tyr 
225                 230                 235                 240 


Ile Lys Asp Tyr Glu Gly Gly Thr Leu Met Gln Cys Ser Met Leu Pro 
                245                 250                 255     


Arg Ile Arg Tyr Leu Asp Ala Gly Lys Ile Leu Leu Leu Gln Glu Ala 
            260                 265                 270         


Ala Leu Arg Arg Lys Ile Arg Thr Ile Ser Lys Ser His Ile Val Arg 
        275                 280                 285             


Pro Gly Leu Glu Gln Phe Lys Asp Leu Asn Asn Ile Lys Pro Ile Asp 
    290                 295                 300                 


Pro Met Thr Ile Pro Gly Leu Lys Glu Ala Gly Trp Thr Pro Glu Met 
305                 310                 315                 320 


Asp Ala Leu Ala Gln Arg Pro Lys Arg Gly Pro His Asp Ala Ala Ile 
                325                 330                 335     


Gln Asn Ile Leu Thr Glu Leu Gln Asn His Ala Ala Ala Trp Pro Phe 
            340                 345                 350         


Leu Gln Pro Val Asn Lys Glu Glu Val Pro Asp Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Lys Glu Pro Met Asp Leu Ser Thr Met Glu Ile Lys Leu Glu Ser Asn 
    370                 375                 380                 


Lys Tyr Gln Lys Met Glu Asp Phe Ile Tyr Asp Ala Arg Leu Val Phe 
385                 390                 395                 400 


Asn Asn Cys Arg Met Tyr Asn Gly Glu Asn Thr Ser Tyr Tyr Lys Tyr 
                405                 410                 415     


Ala Asn Arg Leu Glu Lys Phe Phe Asn Asn Lys Val Lys Glu Ile Pro 
            420                 425                 430         


Glu Tyr Ser His Leu Ile Asp 
        435                 


<210>  6
<211>  2128
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  6
tcttaaacac ttatgggcag caaaaaatgc gtctttcttc cctcgtctgt tgttttatgt       60

agggcgtaat gatgtttgct tgtcaacaaa tgaatacgta cagaagagaa ttctagccaa      120

ggcaattatt gcatactgca agtactgagt acgttaacgt tgctagaata acattaaatg      180

agatgtagca atgcagatcc ttcctcagta ggcttaatgc tccactagaa tttttgacca      240

gccactattt gcttttttcg caatcctttt caatactcga gagcaaagac aaaaaaaata      300

agacatgtag tgcgctgtat ggaaaagaat taattagaac tttacaaacg cgtgttaaac      360

aggcatattt aagtgtttgg acctaaacaa tatatcgact attgaaattc ttacgcaaga      420

ttttttatag ttggatattc atatattctt acaactctct ctactttcag ttttttgaag      480

ctatatgtat cattatatac gtttatggat ttttcaaacc taaacaatta tactgcgtaa      540

atgtttgatt aagcaataaa taaaaacaaa ggattggtaa gggaagaccg tgagccgccc      600

aaaagtcttc agttaactca ggttcgtatt ctacattaga tggtcacaaa acatcagatt      660

gaagaggatc acttggatgg agctacgacg gatcccgaag ttaaacgggt aaaattagaa      720

aacaacgttg aagaaataca acctgagcag gctgagacca ataaacaaga gggcaccgat      780

aaagagaata aaggaaagtt cgagaaagaa actgagagaa taggaggatc tgaagtggtt      840

acagatgtgg aaaaaggaat tgtcaaattt gaatttgatg gtgttgaata cacattcaaa      900

gagagaccca gtgtcgtaga ggaaaatgaa ggtaaaattg agtttagggt ggtgaataat      960

gataatacta aagaaaacat gatggtccta actggattaa aaaacatttt tcaaaagcaa     1020

ttaccaaaaa tgcccaaaga atacattgcc aggttagtct atgatcgaag tcatctttcc     1080

atggctgtca ttaggaagcc attgactgtc gtaggtggca taacatatcg acctttcgat     1140

aagagagaat tcgcagaaat tgttttctgt gccatcagtt cgacggaaca ggtacgcggt     1200

tatggtgcgc atctaatgaa tcacttaaaa gactatgtta gaaatacctc gaacataaaa     1260

tattttttga catatgcaga taattacgct attggatact ttaaaaagca aggcttcact     1320

aaagaaatca cgttggataa aagtatatgg atgggatata ttaaagatta tgaaggtggt     1380

acgctgatgc aatgttctat gttaccaaga atacgatatt tggacgcagg taagattcta     1440

ttattacaag aagcggccct gcgaagaaaa ataagaacga tttcgaaatc gcatattgta     1500

aggcctggtt tagagcaatt caaagactta aacaatatca aaccgattga tccaatgact     1560

attcctggct tgaaagaagc cggctggact cccgagatgg atgcgttggc acaacgtccc     1620

aagcgtggtc cacacgatgc agcaatacag aatatactca cagagctaca aaatcatgca     1680

gcagcttggc ccttcttaca acccgttaat aaagaggagg tccccgacta ttatgatttt     1740

atcaaagagc caatggactt gagcaccatg gaaataaaat tagagagcaa caaatatcag     1800

aagatggaag acttcatata tgatgccaga ttggtgttta acaattgccg aatgtacaat     1860

ggcgagaata cgtcgtatta caagtatgct aataggctag agaaattctt caataataaa     1920

gtaaaagaaa tacctgaata ttctcacctt attgattaat gcgtagaaga agcttttccg     1980

ctactattcc tttcgaagaa gaaataaatg tttagtacgg cgagacgatg tgatcaattg     2040

aggttatttt actacttttc ctttcatttt tgtaaggttt tctttctttg ttagtgtgac     2100

gttggtattt acctttatgt aactatat                                        2128


<210>  7
<211>  2470
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Glu Pro His Glu Glu Gln Ile Trp Lys Ser Lys Leu Leu Lys Ala 
1               5                   10                  15      


Ala Asn Asn Asp Met Asp Met Asp Arg Asn Val Pro Leu Ala Pro Asn 
            20                  25                  30          


Leu Asn Val Asn Met Asn Met Lys Met Asn Ala Ser Arg Asn Gly Asp 
        35                  40                  45              


Glu Phe Gly Leu Thr Ser Ser Arg Phe Asp Gly Val Val Ile Gly Ser 
    50                  55                  60                  


Asn Gly Asp Val Asn Phe Lys Pro Ile Leu Glu Lys Ile Phe Arg Glu 
65                  70                  75                  80  


Leu Thr Ser Asp Tyr Lys Glu Glu Arg Lys Leu Ala Ser Ile Ser Leu 
                85                  90                  95      


Phe Asp Leu Leu Val Ser Leu Glu His Glu Leu Ser Ile Glu Glu Phe 
            100                 105                 110         


Gln Ala Val Ser Asn Asp Ile Asn Asn Lys Ile Leu Glu Leu Val His 
        115                 120                 125             


Thr Lys Lys Thr Ser Thr Arg Val Gly Ala Val Leu Ser Ile Asp Thr 
    130                 135                 140                 


Leu Ile Ser Phe Tyr Ala Tyr Thr Glu Arg Leu Pro Asn Glu Thr Ser 
145                 150                 155                 160 


Arg Leu Ala Gly Tyr Leu Arg Gly Leu Ile Pro Ser Asn Asp Val Glu 
                165                 170                 175     


Val Met Arg Leu Ala Ala Lys Thr Leu Gly Lys Leu Ala Val Pro Gly 
            180                 185                 190         


Gly Thr Tyr Thr Ser Asp Phe Val Glu Phe Glu Ile Lys Ser Cys Leu 
        195                 200                 205             


Glu Trp Leu Thr Ala Ser Thr Glu Lys Asn Ser Phe Ser Ser Ser Lys 
    210                 215                 220                 


Pro Asp His Ala Lys His Arg Ala Leu Leu Ile Ile Thr Ala Leu Ala 
225                 230                 235                 240 


Glu Asn Cys Pro Tyr Leu Leu Tyr Gln Tyr Leu Asn Ser Ile Leu Asp 
                245                 250                 255     


Asn Ile Trp Arg Ala Leu Arg Asp Pro His Leu Val Ile Arg Ile Asp 
            260                 265                 270         


Ala Ser Ile Thr Leu Ala Lys Cys Leu Ser Thr Leu Arg Asn Arg Asp 
        275                 280                 285             


Pro Gln Leu Thr Ser Gln Trp Val Gln Arg Leu Ala Thr Ser Cys Glu 
    290                 295                 300                 


Tyr Gly Phe Gln Val Asn Thr Leu Glu Cys Ile His Ala Ser Leu Leu 
305                 310                 315                 320 


Val Tyr Lys Glu Ile Leu Phe Leu Lys Asp Pro Phe Leu Asn Gln Val 
                325                 330                 335     


Phe Asp Gln Met Cys Leu Asn Cys Ile Ala Tyr Glu Asn His Lys Ala 
            340                 345                 350         


Lys Met Ile Arg Glu Lys Ile Tyr Gln Ile Val Pro Leu Leu Ala Ser 
        355                 360                 365             


Phe Asn Pro Gln Leu Phe Ala Gly Lys Tyr Leu His Gln Ile Met Asp 
    370                 375                 380                 


Asn Tyr Leu Glu Ile Leu Thr Asn Ala Pro Ala Lys Lys Ile Pro His 
385                 390                 395                 400 


Leu Lys Asp Asp Lys Pro Gln Ile Leu Ile Ser Ile Gly Asp Ile Ala 
                405                 410                 415     


Tyr Glu Val Gly Pro Asp Ile Ala Pro Tyr Val Lys Gln Ile Leu Asp 
            420                 425                 430         


Tyr Ile Glu His Asp Leu Gln Thr Lys Phe Lys Phe Arg Lys Lys Phe 
        435                 440                 445             


Glu Asn Glu Ile Phe Tyr Cys Ile Gly Arg Leu Ala Val Pro Leu Gly 
    450                 455                 460                 


Pro Val Leu Gly Lys Leu Leu Asn Arg Asn Ile Leu Asp Leu Met Phe 
465                 470                 475                 480 


Lys Cys Pro Leu Ser Asp Tyr Met Gln Glu Thr Phe Gln Ile Leu Thr 
                485                 490                 495     


Glu Arg Ile Pro Ser Leu Gly Pro Lys Ile Asn Asp Glu Leu Leu Asn 
            500                 505                 510         


Leu Val Cys Ser Thr Leu Ser Gly Thr Pro Phe Ile Gln Pro Gly Ser 
        515                 520                 525             


Pro Met Glu Ile Pro Ser Phe Ser Arg Glu Arg Ala Arg Glu Trp Arg 
    530                 535                 540                 


Asn Lys Ser Ile Leu Gln Lys Thr Gly Glu Ser Asn Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Lys Ile Ile Ile Gln Ala Phe Arg Met Leu Lys Asn Ile Lys 
                565                 570                 575     


Ser Arg Phe Ser Leu Val Glu Phe Val Arg Ile Val Ala Leu Ser Tyr 
            580                 585                 590         


Ile Glu His Thr Asp Pro Arg Val Arg Lys Leu Ala Ala Leu Thr Ser 
        595                 600                 605             


Cys Glu Ile Tyr Val Lys Asp Asn Ile Cys Lys Gln Thr Ser Leu His 
    610                 615                 620                 


Ser Leu Asn Thr Val Ser Glu Val Leu Ser Lys Leu Leu Ala Ile Thr 
625                 630                 635                 640 


Ile Ala Asp Pro Leu Gln Asp Ile Arg Leu Glu Val Leu Lys Asn Leu 
                645                 650                 655     


Asn Pro Cys Phe Asp Pro Gln Leu Ala Gln Pro Asp Asn Leu Arg Leu 
            660                 665                 670         


Leu Phe Ile Ala Leu His Asp Glu Ser Phe Asn Ile Gln Ser Val Ala 
        675                 680                 685             


Met Glu Leu Val Gly Arg Leu Ser Ser Val Asn Pro Ala Tyr Val Ile 
    690                 695                 700                 


Pro Ser Ile Arg Lys Ile Leu Leu Glu Leu Leu Thr Lys Leu Lys Phe 
705                 710                 715                 720 


Ser Thr Ser Ser Arg Glu Lys Glu Glu Thr Ala Ser Leu Leu Cys Thr 
                725                 730                 735     


Leu Ile Arg Ser Ser Lys Asp Val Ala Lys Pro Tyr Ile Glu Pro Leu 
            740                 745                 750         


Leu Asn Val Leu Leu Pro Lys Phe Gln Asp Thr Ser Ser Thr Val Ala 
        755                 760                 765             


Ser Thr Ala Leu Arg Thr Ile Gly Glu Leu Ser Val Val Gly Gly Glu 
    770                 775                 780                 


Asp Met Lys Ile Tyr Leu Lys Asp Leu Phe Pro Leu Ile Ile Lys Thr 
785                 790                 795                 800 


Phe Gln Asp Gln Ser Asn Ser Phe Lys Arg Glu Ala Ala Leu Lys Ala 
                805                 810                 815     


Leu Gly Gln Leu Ala Ala Ser Ser Gly Tyr Val Ile Asp Pro Leu Leu 
            820                 825                 830         


Asp Tyr Pro Glu Leu Leu Gly Ile Leu Val Asn Ile Leu Lys Thr Glu 
        835                 840                 845             


Asn Ser Gln Asn Ile Arg Arg Gln Thr Val Thr Leu Ile Gly Ile Leu 
    850                 855                 860                 


Gly Ala Ile Asp Pro Tyr Arg Gln Lys Glu Arg Glu Val Thr Ser Thr 
865                 870                 875                 880 


Thr Asp Ile Ser Thr Glu Gln Asn Ala Pro Pro Ile Asp Ile Ala Leu 
                885                 890                 895     


Leu Met Gln Gly Met Ser Pro Ser Asn Asp Glu Tyr Tyr Thr Thr Val 
            900                 905                 910         


Val Ile His Cys Leu Leu Lys Ile Leu Lys Asp Pro Ser Leu Ser Ser 
        915                 920                 925             


Tyr His Thr Ala Val Ile Gln Ala Ile Met His Ile Phe Gln Thr Leu 
    930                 935                 940                 


Gly Leu Lys Cys Val Ser Phe Leu Asp Gln Ile Ile Pro Thr Ile Leu 
945                 950                 955                 960 


Asp Val Met Arg Thr Cys Ser Gln Ser Leu Leu Glu Phe Tyr Phe Gln 
                965                 970                 975     


Gln Leu Cys Ser Leu Ile Ile Ile Val Arg Gln His Ile Arg Pro His 
            980                 985                 990         


Val Asp Ser Ile Phe Gln Ala Ile  Lys Asp Phe Ser Ser  Val Ala Lys 
        995                 1000                 1005             


Leu Gln  Ile Thr Leu Val Ser  Val Ile Glu Ala Ile  Ser Lys Ala 
    1010                 1015                 1020             


Leu Glu  Gly Glu Phe Lys Arg  Leu Val Pro Leu Thr  Leu Thr Leu 
    1025                 1030                 1035             


Phe Leu  Val Ile Leu Glu Asn  Asp Lys Ser Ser Asp  Lys Val Leu 
    1040                 1045                 1050             


Ser Arg  Arg Val Leu Arg Leu  Leu Glu Ser Phe Gly  Pro Asn Leu 
    1055                 1060                 1065             


Glu Gly  Tyr Ser His Leu Ile  Thr Pro Lys Ile Val  Gln Met Ala 
    1070                 1075                 1080             


Glu Phe  Thr Ser Gly Asn Leu  Gln Arg Ser Ala Ile  Ile Thr Ile 
    1085                 1090                 1095             


Gly Lys  Leu Ala Lys Asp Val  Asp Leu Phe Glu Met  Ser Ser Arg 
    1100                 1105                 1110             


Ile Val  His Ser Leu Leu Arg  Val Leu Ser Ser Thr  Thr Ser Asp 
    1115                 1120                 1125             


Glu Leu  Ser Lys Val Ile Met  Asn Thr Leu Ser Leu  Leu Leu Ile 
    1130                 1135                 1140             


Gln Met  Gly Thr Ser Phe Ala  Ile Phe Ile Pro Val  Ile Asn Glu 
    1145                 1150                 1155             


Val Leu  Met Lys Lys His Ile  Gln His Thr Ile Tyr  Asp Asp Leu 
    1160                 1165                 1170             


Thr Asn  Arg Ile Leu Asn Asn  Asp Val Leu Pro Thr  Lys Ile Leu 
    1175                 1180                 1185             


Glu Ala  Asn Thr Thr Asp Tyr  Lys Pro Ala Glu Gln  Met Glu Ala 
    1190                 1195                 1200             


Ala Asp  Ala Gly Val Ala Lys  Leu Pro Ile Asn Gln  Ser Val Leu 
    1205                 1210                 1215             


Lys Ser  Ala Trp Asn Ser Ser  Gln Gln Arg Thr Lys  Glu Asp Trp 
    1220                 1225                 1230             


Gln Glu  Trp Ser Lys Arg Leu  Ser Ile Gln Leu Leu  Lys Glu Ser 
    1235                 1240                 1245             


Pro Ser  His Ala Leu Arg Ala  Cys Ser Asn Leu Ala  Ser Met Tyr 
    1250                 1255                 1260             


Tyr Pro  Leu Ala Lys Glu Leu  Phe Asn Thr Ala Phe  Ala Cys Val 
    1265                 1270                 1275             


Trp Thr  Glu Leu Tyr Ser Gln  Tyr Gln Glu Asp Leu  Ile Glu Ser 
    1280                 1285                 1290             


Leu Cys  Ile Ala Leu Ser Ser  Pro Leu Asn Pro Pro  Glu Ile His 
    1295                 1300                 1305             


Gln Thr  Leu Leu Asn Leu Val  Glu Phe Met Glu His  Asp Asp Lys 
    1310                 1315                 1320             


Ala Leu  Pro Ile Pro Thr Gln  Ser Leu Gly Glu Tyr  Ala Glu Arg 
    1325                 1330                 1335             


Cys His  Ala Tyr Ala Lys Ala  Leu His Tyr Lys Glu  Ile Lys Phe 
    1340                 1345                 1350             


Ile Lys  Glu Pro Glu Asn Ser  Thr Ile Glu Ser Leu  Ile Ser Ile 
    1355                 1360                 1365             


Asn Asn  Gln Leu Asn Gln Thr  Asp Ala Ala Ile Gly  Ile Leu Lys 
    1370                 1375                 1380             


His Ala  Gln Gln His His Ser  Leu Gln Leu Lys Glu  Thr Trp Phe 
    1385                 1390                 1395             


Glu Lys  Leu Glu Arg Trp Glu  Asp Ala Leu His Ala  Tyr Asn Glu 
    1400                 1405                 1410             


Arg Glu  Lys Ala Gly Asp Thr  Ser Val Ser Val Thr  Leu Gly Lys 
    1415                 1420                 1425             


Met Arg  Ser Leu His Ala Leu  Ala Glu Trp Glu Gln  Leu Ser Gln 
    1430                 1435                 1440             


Leu Ala  Ala Arg Lys Trp Lys  Val Ser Lys Leu Gln  Thr Lys Lys 
    1445                 1450                 1455             


Leu Ile  Ala Pro Leu Ala Ala  Gly Ala Arg Gly Gly  Ser Gly Glu 
    1460                 1465                 1470             


Trp Asp  Met Leu Asp Glu Tyr  Ile Ser Val Met Lys  Pro Lys Ser 
    1475                 1480                 1485             


Pro Asp  Lys Glu Phe Phe Asp  Ala Ile Leu Tyr Leu  His Lys Asn 
    1490                 1495                 1500             


Asp Tyr  Asp Asn Ala Ser Lys  His Ile Leu Asn Ala  Arg Asp Leu 
    1505                 1510                 1515             


Leu Val  Thr Glu Ile Ser Ala  Leu Ile Asn Glu Ser  Tyr Asn Arg 
    1520                 1525                 1530             


Ala Tyr  Ser Val Ile Val Arg  Thr Gln Ile Ile Thr  Glu Phe Glu 
    1535                 1540                 1545             


Glu Ile  Ile Lys Tyr Lys Gln  Leu Pro Pro Asn Ser  Glu Lys Lys 
    1550                 1555                 1560             


Leu His  Tyr Gln Asn Leu Trp  Thr Lys Arg Leu Leu  Gly Cys Gln 
    1565                 1570                 1575             


Lys Asn  Val Asp Leu Trp Gln  Arg Val Leu Arg Ile  Arg Ser Leu 
    1580                 1585                 1590             


Val Ile  Lys Pro Lys Gln Asp  Leu Gln Ile Trp Ile  Lys Phe Ala 
    1595                 1600                 1605             


Asn Leu  Cys Arg Lys Ser Gly  Arg Met Arg Leu Ala  Asn Lys Ala 
    1610                 1615                 1620             


Leu Asn  Met Leu Leu Glu Gly  Gly Thr Ile Leu Val  Tyr Gln Ile 
    1625                 1630                 1635             


Arg Ser  Lys Pro Pro Pro Pro  Val Val Tyr Ala Gln  Leu Lys Tyr 
    1640                 1645                 1650             


Ile Trp  Ala Thr Gly Ala Tyr  Lys Glu Ala Leu Asn  His Leu Ile 
    1655                 1660                 1665             


Gly Phe  Thr Ser Arg Leu Ala  His Asp Leu Gly Leu  Asp Pro Asn 
    1670                 1675                 1680             


Asn Met  Ile Ala Gln Ser Val  Lys Leu Ser Ser Ala  Ser Thr Ala 
    1685                 1690                 1695             


Pro Tyr  Val Glu Glu Tyr Thr  Lys Leu Leu Ala Arg  Cys Phe Leu 
    1700                 1705                 1710             


Lys Gln  Gly Glu Trp Arg Ile  Ala Thr Gln Pro Asn  Trp Arg Asn 
    1715                 1720                 1725             


Thr Asn  Pro Asp Ala Ile Leu  Gly Ser Tyr Leu Leu  Ala Thr His 
    1730                 1735                 1740             


Phe Asp  Lys Asn Trp Tyr Lys  Ala Trp His Asn Trp  Ala Leu Ala 
    1745                 1750                 1755             


Asn Phe  Glu Val Ile Ser Met  Val Gln Glu Glu Thr  Lys Leu Asn 
    1760                 1765                 1770             


Gly Gly  Lys Asn Asp Asp Asp  Asp Asp Thr Ala Val  Asn Asn Asp 
    1775                 1780                 1785             


Asn Val  Arg Ile Asp Gly Ser  Ile Leu Gly Ser Gly  Ser Leu Thr 
    1790                 1795                 1800             


Ile Asn  Gly Asn Arg Tyr Pro  Leu Glu Leu Ile Gln  Arg His Val 
    1805                 1810                 1815             


Val Pro  Ala Ile Lys Gly Phe  Phe His Ser Ile Ser  Leu Leu Glu 
    1820                 1825                 1830             


Thr Ser  Cys Leu Gln Asp Thr  Leu Arg Leu Ser Thr  Leu Leu Phe 
    1835                 1840                 1845             


Asn Phe  Gly Gly Ile Lys Glu  Val Ser Gln Ala Met  Tyr Glu Gly 
    1850                 1855                 1860             


Phe Asn  Leu Met Lys Ile Glu  Asn Trp Leu Glu Val  Leu Pro Gln 
    1865                 1870                 1875             


Leu Ile  Ser Arg Ile His Gln  Pro Asp Pro Thr Val  Ser Asn Ser 
    1880                 1885                 1890             


Leu Leu  Ser Leu Leu Ser Asp  Leu Gly Lys Ala His  Pro Gln Ala 
    1895                 1900                 1905             


Leu Val  Tyr Pro Leu Thr Val  Ala Ile Lys Ser Glu  Ser Val Ser 
    1910                 1915                 1920             


Arg Gln  Lys Ala Ala Leu Ser  Ile Ile Glu Lys Ile  Arg Ile His 
    1925                 1930                 1935             


Ser Pro  Val Leu Val Asn Gln  Ala Glu Leu Val Ser  His Glu Leu 
    1940                 1945                 1950             


Ile Arg  Val Ala Val Leu Trp  His Glu Leu Trp Tyr  Glu Gly Leu 
    1955                 1960                 1965             


Glu Asp  Ala Ser Arg Gln Phe  Phe Val Glu His Asn  Ile Glu Lys 
    1970                 1975                 1980             


Met Phe  Ser Thr Leu Glu Pro  Leu His Lys His Leu  Gly Asn Glu 
    1985                 1990                 1995             


Pro Gln  Thr Leu Ser Glu Val  Ser Phe Gln Lys Ser  Phe Gly Arg 
    2000                 2005                 2010             


Asp Leu  Asn Asp Ala Tyr Glu  Trp Leu Asn Asn Tyr  Lys Lys Ser 
    2015                 2020                 2025             


Lys Asp  Ile Asn Asn Leu Asn  Gln Ala Trp Asp Ile  Tyr Tyr Asn 
    2030                 2035                 2040             


Val Phe  Arg Lys Ile Thr Arg  Gln Ile Pro Gln Leu  Gln Thr Leu 
    2045                 2050                 2055             


Asp Leu  Gln His Val Ser Pro  Gln Leu Leu Ala Thr  His Asp Leu 
    2060                 2065                 2070             


Glu Leu  Ala Val Pro Gly Thr  Tyr Phe Pro Gly Lys  Pro Thr Ile 
    2075                 2080                 2085             


Arg Ile  Ala Lys Phe Glu Pro  Leu Phe Ser Val Ile  Ser Ser Lys 
    2090                 2095                 2100             


Gln Arg  Pro Arg Lys Phe Ser  Ile Lys Gly Ser Asp  Gly Lys Asp 
    2105                 2110                 2115             


Tyr Lys  Tyr Val Leu Lys Gly  His Glu Asp Ile Arg  Gln Asp Ser 
    2120                 2125                 2130             


Leu Val  Met Gln Leu Phe Gly  Leu Val Asn Thr Leu  Leu Lys Asn 
    2135                 2140                 2145             


Asp Ser  Glu Cys Phe Lys Arg  His Leu Asp Ile Gln  Gln Tyr Pro 
    2150                 2155                 2160             


Ala Ile  Pro Leu Ser Pro Lys  Ser Gly Leu Leu Gly  Trp Val Pro 
    2165                 2170                 2175             


Asn Ser  Asp Thr Phe His Val  Leu Ile Arg Glu His  Arg Asp Ala 
    2180                 2185                 2190             


Lys Lys  Ile Pro Leu Asn Ile  Glu His Trp Val Met  Leu Gln Met 
    2195                 2200                 2205             


Ala Pro  Asp Tyr Glu Asn Leu  Thr Leu Leu Gln Lys  Ile Glu Val 
    2210                 2215                 2220             


Phe Thr  Tyr Ala Leu Asp Asn  Thr Lys Gly Gln Asp  Leu Tyr Lys 
    2225                 2230                 2235             


Ile Leu  Trp Leu Lys Ser Arg  Ser Ser Glu Thr Trp  Leu Glu Arg 
    2240                 2245                 2250             


Arg Thr  Thr Tyr Thr Arg Ser  Leu Ala Val Met Ser  Met Thr Gly 
    2255                 2260                 2265             


Tyr Ile  Leu Gly Leu Gly Asp  Arg His Pro Ser Asn  Leu Met Leu 
    2270                 2275                 2280             


Asp Arg  Ile Thr Gly Lys Val  Ile His Ile Asp Phe  Gly Asp Cys 
    2285                 2290                 2295             


Phe Glu  Ala Ala Ile Leu Arg  Glu Lys Tyr Pro Glu  Lys Val Pro 
    2300                 2305                 2310             


Phe Arg  Leu Thr Arg Met Leu  Thr Tyr Ala Met Glu  Val Ser Gly 
    2315                 2320                 2325             


Ile Glu  Gly Ser Phe Arg Ile  Thr Cys Glu Asn Val  Met Arg Val 
    2330                 2335                 2340             


Leu Arg  Asp Asn Lys Glu Ser  Leu Met Ala Ile Leu  Glu Ala Phe 
    2345                 2350                 2355             


Ala Leu  Asp Pro Leu Ile His  Trp Gly Phe Asp Leu  Pro Pro Gln 
    2360                 2365                 2370             


Lys Leu  Thr Glu Gln Thr Gly  Ile Pro Leu Pro Leu  Ile Asn Pro 
    2375                 2380                 2385             


Ser Glu  Leu Leu Arg Lys Gly  Ala Ile Thr Val Glu  Glu Ala Ala 
    2390                 2395                 2400             


Asn Met  Glu Ala Glu Gln Gln  Asn Glu Thr Arg Asn  Ala Arg Ala 
    2405                 2410                 2415             


Met Leu  Val Leu Arg Arg Ile  Thr Asp Lys Leu Thr  Gly Asn Asp 
    2420                 2425                 2430             


Ile Lys  Arg Phe Asn Glu Leu  Asp Val Pro Glu Gln  Val Asp Lys 
    2435                 2440                 2445             


Leu Ile  Gln Gln Ala Thr Ser  Ile Glu Arg Leu Cys  Gln His Tyr 
    2450                 2455                 2460             


Ile Gly  Trp Cys Pro Phe Trp  
    2465                 2470 


<210>  8
<211>  7413
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  8
atggaaccgc atgaggagca gatttggaag agtaaacttt tgaaagcggc taacaacgat       60

atggacatgg atagaaatgt gccgttggca ccgaatctga atgtgaatat gaacatgaaa      120

atgaatgcga gcaggaacgg ggatgaattc ggtctgactt ctagtaggtt tgatggagtg      180

gtgattggca gtaatgggga tgtaaatttt aagcccattt tggagaaaat tttccgcgaa      240

ttaaccagtg attacaagga ggaacgaaaa ttggccagta tttcattatt tgatctacta      300

gtatccttgg aacatgaatt gtcgatagaa gagttccaag cagtttcaaa tgacataaac      360

aataagattt tggagctggt ccatacaaaa aaaacgagca ctagggtagg ggctgttcta      420

tccatagaca ctttgatttc attctacgca tatactgaaa ggttgcctaa cgaaacttca      480

cgactggctg gttaccttcg agggctaata ccttctaatg atgtagaggt catgagactc      540

gctgcaaaga ctctgggcaa gttagccgtt ccaggaggta catatacctc tgatttcgtg      600

gaatttgaga taaagtcttg cttagaatgg cttactgcct ccacggaaaa gaattcattc      660

tcgagttcga agccagacca tgctaaacat gctgcgcttc tgattataac agcgttggca      720

gagaattgtc cttatttact ctaccaatac ttgaattcca tactagataa catttggaga      780

gcactaagag acccacattt ggtgatcaga attgatgcgt ccattacatt ggccaaatgt      840

ctttccaccc tacgaaatag ggatcctcag ttaactagcc agtgggtgca gagattggct      900

acaagttgtg aatacggatt tcaagtaaac acattagaat gcatccatgc aagtttgttg      960

gtttataagg aaatcttgtt tttgaaggat ccctttttga atcaagtgtt cgaccaaatg     1020

tgtctaaatt gcatagctta tgaaaatcat aaagcgaaaa tgattagaga aaagatttac     1080

cagattgttc ccctattagc atcgttcaat cctcaattat ttgctggcaa atatttgcac     1140

caaattatgg acaactattt agagatttta accaatgctc cagcaaataa aataccacat     1200

ctcaaagatg acaaaccaca gattttaata tcgattggtg atattgcata tgaagtcggg     1260

cccgatatcg caccttatgt gaaacaaatt cttgattata ttgaacatga tttacagacg     1320

aaattcaaat tcagaaagaa atttgaaaat gaaattttct actgcatcgg aagattggca     1380

gttcccttgg gccccgttct aggtaaatta ttaaacagaa atatactgga cctgatgttc     1440

aaatgccctc tttccgacta tatgcaggaa acgtttcaaa ttctgactga gagaatacca     1500

tcactaggcc ccaaaataaa tgacgagttg cttaacctag tctgttcaac cttatctgga     1560

acaccattta tccagccagg gtcaccaatg gagataccat cgttttcgag agaaagagca     1620

agagaatgga gaaataaaaa catcctacag aaaactggtg aaagtaacga tgataataat     1680

gatataaaaa tcattataca agcttttaga atgttaaaaa atatcaaaag cagattttcg     1740

ttggtggaat tcgtgagaat tgttgcactt tcttacattg agcatacaga tcccagagta     1800

aggaaactag ctgcgttgac atcttgtgaa atttacgtca aggataacat ctgcaaacaa     1860

acatcactac actctctgaa cactgtatct gaagtgttat caaagcttct agccattacg     1920

attgcggacc ctttacaaga tatccgttta gaagttttaa agaatcttaa tccatgtttc     1980

gatccccagt tggcacaacc agataatttg agactcttgt ttactgcact gcacgatgag     2040

tcgttcaata ttcagtcagt agcaatggag cttgtcggta ggttgtcttc cgtaaaccct     2100

gcatacgtca tcccatcgat aagaaaaata ctactggaac tgctaacaaa attaaaattc     2160

tcaacttctt ctcgagaaaa ggaagaaact gccagtttgt tatgtactct tatcaggtcg     2220

agtaaagatg ttgcgaaacc ttatatcgaa cctcttttaa atgttctttt accaaaattc     2280

caagatacct cttcaacggt tgcatcaact gcactgagaa ctataggtga gctatctgtt     2340

gtagggggcg aagatatgaa gatatatctt aaggatttgt ttcctttaat tatcaaaaca     2400

tttcaggatc aatcaaactc tttcaagaga gaagctgcac ttaaggccct tggtcaactt     2460

gcagcctcat ctggttacgt gatagatcct ttactcgact atcccgaatt attgggtata     2520

ttggtgaata tattgaagac agaaaactct caaaatatta ggagacaaac agtcactttg     2580

ataggtatac tgggagctat cgacccatat cgccaaaaag aacgtgaggt tacctctact     2640

accgatatat ctacagaaca gaacgccccg cctatcgaca ttgctcttct catgcagggc     2700

atgtctcctt cgaatgatga gtattatacc actgttgtca ttcactgcct gctaaaaatc     2760

ctaaaagatc catccctatc atcttaccac actgccgtga tccaagcgat tatgcatatt     2820

tttcaaaccc ttggtctaaa atgtgtttca ttcttggacc agatcatccc aactattttg     2880

gacgtaatgc gtacatgctc tcagtcacta ttagaatttt acttccaaca gctttgctct     2940

ttgattatta tcgtaaggca acacataaga cctcatgtcg attctatatt ccaggctatc     3000

aaagattttt cttcggttgc taagctacaa ataacgcttg taagtgttat tgaagcaata     3060

tcaaaggctc tggagggtga attcaaaaga ttggtccctc ttactctgac cttgttcctt     3120

gtaattttgg agaatgacaa gtctagtgac aaggtcctct ccagaagggt attgagactg     3180

ttagaatcgt ttggtcctaa cttagaaggt tattcgcatt tgattacacc caagatagtt     3240

caaatggcag aattcaccag cgggaaccta caaaggtctg caataattac tattggcaaa     3300

ctggccaagg atgttgacct ttttgagatg tcctcaagaa ttgttcactc tttacttagg     3360

gtactaagtt caacaacgag tgacgaactc tcaaaagtca ttatgaatac tttaagtcta     3420

ctgctaatac aaatgggcac atcctttgct atcttcatcc ctgtcattaa tgaagtttta     3480

atgaagaaac atattcaaca cacaatatat gatgacttga caaacagaat attaaacaat     3540

gatgttttac ccacaaaaat tcttgaagca aatacaacgg attataagcc cgcggaacaa     3600

atggaggcag cagatgctgg ggtcgcaaaa ttacctataa accaatcagt tttgaaaagt     3660

gcatggaatt ctagccaaca aagaactaaa gaagattggc aggaatggag caaacgtcta     3720

tccattcaat tattaaaaga gtcaccctcc catgctctaa gagcttgttc aaatcttgca     3780

agcatgtatt atccactagc caaagaactt tttaataccg cattcgcatg tgtttggacc     3840

gaactttata gccaatatca agaagattta attgggtcat tatgtatagc cttatcttct     3900

cccttaaatc caccagaaat acatcaaaca ttgttaaacc tggtagaatt tatggaacac     3960

gatgacaagg cattaccaat accaactcaa agcctgggcg agtatgctga aagatgtcac     4020

gcctatgcca aagcgctaca ttataaagag attaaattta ttaaagagcc tgagaactca     4080

actattgaat cattgatcag cattaacaac cagctgaatc aaacggatgc tgcaattggt     4140

atattaaagc atgcccaaca acatcattca cttcaattaa aggagacatg gtttgaaaaa     4200

ttagagcgtt gggaagatgc actacatgct tataatgaac gtgaaaaggc aggtgatact     4260

tccgtgagcg ttacactcgg taagatgaga tcccttcatg cccttggcga atgggaacag     4320

ttgtcgcaat tggcagctag aaagtggaaa gtttcgaagc tacaaactaa gaagctaata     4380

gctcccttgg cagctggtgc tgcgtggggg ttgggagagt gggatatgct tgagcaatat     4440

atcagcgtta tgaaacctaa atctccagat aaggaatttt ttgatgcaat tttatacttg     4500

cacaagaatg attacgacaa tgctagtaag catatattaa acgccagaga tttgcttgtg     4560

actgaaattt ccgcgttgat caatgaaagt tataatagag catatagcgt tattgttaga     4620

actcaaataa taacagagtt tgaggaaatc atcaagtata aacaattgcc acctaattcc     4680

gagaaaaaac ttcactatca aaatctttgg acaaaaagac tgctgggctg ccaaaaaaat     4740

gtcgatttat ggcaaagagt gcttagagta agatcattgg taataaagcc caagcaagac     4800

ctgcaaatat ggataaaatt tgcaaatttg tgcagaaaat ctggtagaat gaggctagca     4860

aataaggcat tgaatatgct actagaagga ggcaacgatc ctagtttacc aaatacgttc     4920

aaagctcctc ccccagttgt ttacgcgcaa ctaaaatata tttgggctac aggagcttat     4980

aaagaagcat taaaccactt gataggattt acatccaggt tagcgcatga tcttggtttg     5040

gatccgaata atatgatcgc gcaaagtgtc aaactctcaa gtgcaagtac tgctccgtat     5100

gttgaggaat acacaaaatt attagctcga tgttttttaa agcaaggtga gtggagaata     5160

gcaacacaac cgaactggag aaacacaaat ccggatgcaa ttcttggttc ttatctattg     5220

gctacacatt tcgataaaaa ttggtacaag gcatggcata attgggcctt agctaatttt     5280

gaagtaatat ccatggttca ggaagagact aagctcaacg gaggtaagaa tgatgatgat     5340

gatgacacgg cagttaataa tgataatgtg cggattgacg gtagtatcct aggaagtggt     5400

tctttgacta ttaatggcaa cagatacccg ctagagctta ttcaaagaca tgttgttcca     5460

gcgatcaagg gcttttttca ttcaatatct ctattagaaa caagttgttt gcaagacacg     5520

ttgaggttat tgactctttt atttaacttt ggtggtatta aagaagtctc acaagccatg     5580

tatgaaggct tcaatttgat gaaaatagag aactggcttg aagtcttacc acagttgatc     5640

tctcgtatac atcagccaga tcctacggtg agtaattccc ttttgtcgtt gctttctgat     5700

ttagggaaag ctcatccaca agctctcgtg tatcctttaa ctgtcgcgat caagtctgaa     5760

tctgtttcaa gacaaaaagc ggctctttca ataatagaga aaattaggat tcatagtcca     5820

gtcctggtaa accaggcaga attagttagt cacgagttga tcagagtagc cgttctatgg     5880

cacgaattat ggtatgaagg actggaagat gcgagccgcc aatttttcgt tgaacataac     5940

atagaaaaaa tgttttctac tttagaacct ttacataaac acttaggcaa tgagcctcaa     6000

acgttaagtg aggtatcgtt tcagaaatca tttggtagag atttgaacga tgcctacgaa     6060

tggttgaata actacaaaaa gtcaaaagac atcaataatt tgaaccaagc ttgggatatt     6120

tattataacg tcttcagaaa aataacacgt caaataccac agttacaaac cttagactta     6180

cagcatgttt ctccccagct tctggctact catgatctcg aattggctgt tcctgggaca     6240

tatttcccag gaaaacctac cattagaata gcgaagtttg agccattatt ttctgtgatc     6300

tcttcgaagc aaaggccaag aaaattctcc atcaagggta gcgacggtaa agattataaa     6360

tacgttttaa agggacatga agatataaga caagatagcc ttgttatgca attatttggt     6420

ctagttaaca ctttgttgaa gaatgattca gagtgtttca agagacattt ggatatccaa     6480

caatacccgg ctattccatt gtcgcctaaa tctggtttac taggatgggt accaaatagt     6540

gacacattcc acgttttgat cagagaacac cgtgatgcca aaaaaattcc gttgaacatt     6600

gaacattggg ttatgttaca aatggccccc gattatgaga atttgactct tttacaaaaa     6660

attgaagtat tcacgtacgc tttagataat acaaaaggcc aagaccttta taaaatatta     6720

tggttaaaga gtaggtcgtc agagacatgg ctagaacgta gaacaactta tacgagatct     6780

ttagcagtta tgtccatgac tggttatatt ctgggactag gtgatcgcca tccaagcaac     6840

ctgatgctag atagaatcac cggtaaagtt atccacattg atttcggcga ttgttttgaa     6900

gctgccatct taagagaaaa gtatccagaa aaagtgccat ttagactaac taggatgtta     6960

acatacgcaa tggaagttag tggaattgaa ggcagtttcc gaattacttg tgaaaatgtc     7020

atgagagtct taagagataa taaagaatca ttaatggcga tcttggaagc ttttgcgctt     7080

gatcctttga tccattgggg atttgattta ccgccacaaa aacttactga gcaaactgga     7140

attcctttgc cgttgattaa tcctagtgaa ttattaagga agggggcaat tactgtcgaa     7200

gaagcggcaa atatggaagc agaacaacaa aatgagacca aaaacgccag agcaatgctt     7260

gttttgagac gtattacaga taaattaacg ggcaatgata tcaagaggtt caatgaatta     7320

gacgtccctg agcaggttga taaactgatc caacaagcca cttctattga aaggttatgt     7380

caacattata ttggatggtg cccattctgg tga                                  7413


<210>  9
<211>  471
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ser Ile Cys Pro His Ile Gln Gln Val Phe Gln Asn Glu Lys Ser 
1               5                   10                  15      


Lys Asp Gly Val Leu Lys Thr Cys Asn Ala Ala Arg Tyr Ile Leu Asn 
            20                  25                  30          


His Ser Val Pro Lys Glu Lys Phe Leu Asn Thr Met Lys Cys Gly Thr 
        35                  40                  45              


Cys His Glu Ile Asn Ser Gly Ala Thr Phe Met Cys Leu Gln Cys Gly 
    50                  55                  60                  


Phe Cys Gly Cys Trp Asn His Ser His Phe Leu Ser His Ser Lys Gln 
65                  70                  75                  80  


Ile Gly His Ile Phe Gly Ile Asn Ser Asn Asn Gly Leu Leu Phe Cys 
                85                  90                  95      


Phe Lys Cys Glu Asp Tyr Ile Gly Asn Ile Asp Leu Ile Asn Asp Ala 
            100                 105                 110         


Ile Leu Ala Lys Tyr Trp Asp Asp Val Cys Thr Lys Thr Met Val Pro 
        115                 120                 125             


Ser Met Glu Arg Arg Asp Gly Leu Ser Gly Leu Ile Asn Met Gly Ser 
    130                 135                 140                 


Thr Cys Phe Met Ser Ser Ile Leu Gln Cys Leu Ile His Asn Pro Tyr 
145                 150                 155                 160 


Phe Ile Arg His Ser Met Ser Gln Ile His Ser Asn Asn Cys Lys Val 
                165                 170                 175     


Arg Ser Pro Asp Lys Cys Phe Ser Cys Ala Leu Asp Lys Ile Val His 
            180                 185                 190         


Glu Leu Tyr Gly Ala Leu Asn Thr Lys Gln Ala Ser Ser Ser Ser Thr 
        195                 200                 205             


Ser Thr Asn Arg Gln Thr Gly Phe Ile Tyr Leu Leu Thr Cys Ala Trp 
    210                 215                 220                 


Lys Ile Asn Gln Asn Leu Ala Gly Tyr Ser Gln Gln Asp Ala His Glu 
225                 230                 235                 240 


Phe Trp Gln Phe Ile Ile Asn Gln Ile His Gln Ser Tyr Val Leu Asp 
                245                 250                 255     


Leu Pro Asn Ala Lys Glu Val Ser Arg Ala Asn Asn Lys Gln Cys Glu 
            260                 265                 270         


Cys Ile Val His Thr Val Phe Glu Gly Ser Leu Glu Ser Ser Ile Val 
        275                 280                 285             


Cys Pro Gly Cys Gln Asn Asn Ser Lys Thr Thr Ile Asp Pro Phe Leu 
    290                 295                 300                 


Asp Leu Ser Leu Asp Ile Lys Asp Lys Lys Lys Leu Tyr Glu Cys Leu 
305                 310                 315                 320 


Asp Ser Phe His Lys Lys Glu Gln Leu Lys Asp Phe Asn Tyr His Cys 
                325                 330                 335     


Gly Glu Cys Asn Ser Thr Gln Asp Ala Ile Lys Gln Leu Gly Ile His 
            340                 345                 350         


Lys Leu Pro Ser Val Leu Val Leu Gln Leu Lys Arg Phe Glu His Leu 
        355                 360                 365             


Leu Asn Gly Ser Asn Arg Lys Leu Asp Asp Phe Ile Glu Phe Pro Thr 
    370                 375                 380                 


Tyr Leu Asn Met Lys Asn Tyr Cys Ser Thr Lys Glu Lys Asp Lys His 
385                 390                 395                 400 


Ser Glu Asn Gly Lys Val Pro Asp Ile Ile Tyr Glu Leu Ile Gly Ile 
                405                 410                 415     


Val Ser His Lys Gly Thr Val Asn Glu Gly His Tyr Ile Ala Phe Cys 
            420                 425                 430         


Lys Ile Ser Gly Gly Gln Trp Phe Lys Phe Asn Asp Ser Met Val Ser 
        435                 440                 445             


Ser Ile Ser Gln Glu Glu Val Leu Lys Glu Gln Ala Tyr Leu Leu Phe 
    450                 455                 460                 


Tyr Thr Ile Arg Gln Val Asn 
465                 470     


<210>  10
<211>  1416
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  10
atgagcattt gtccacatat acagcaagta tttcagaatg aaaagtctaa agatggggtt       60

ctaaaaacgt gcaatgctgc caggtatata ttaaatcatt ccgtacccaa ggaaaaattc      120

ttaaacacca tgaaatgtgg tacatgccac gaaataaact ctggtgcaac tttcatgtgt      180

ctacaatgtg gattttgtgg atgttggaac cattcgcatt ttctctctca cagtaaacag      240

attggtcaca tatttggtat caactcaaat aatggccttt tattttgctt caaatgtgag      300

gactatatag ggaatatcga tctgattaac gatgctatcc tagcgaagta ttgggacgac      360

gtgtgcacaa agaccatggt tcctagcatg gaaagaagag atgggctttc tggcctgatc      420

aacatgggat ccacttgttt catgagtagt attctccaat gtctaatcca taacccttac      480

tttattaggc actcaatgag tcaaattcat tctaataatt gtaaagtgcg ttctccagat      540

aaatgttttt catgtgcact cgataaaatt gttcatgaac tttatggagc gctgaataca      600

aagcaagctt cttcgtcatc tacatctact aatcggcaaa ccggattcat atatctttta      660

acttgtgcct ggaaaatcaa tcaaaatcta gcagggtatt cacaacaaga tgctcatgaa      720

ttttggcagt ttataattaa ccaaatccac caaagctatg ttcttgattt gccaaatgcc      780

aaggaagtca gcagagcaaa taataagcag tgtgaatgca tagtgcatac tgtgtttgag      840

ggctccttgg aaagttctat tgtgtgtcca ggctgtcaaa ataattcaaa gacaaccatt      900

gatccattct tggatctttc tctggatatc aaggataaga aaaaacttta tgaatgtctt      960

gacagtttcc ataaaaaaga acagttgaag gatttcaact atcattgtgg ggagtgtaac     1020

agcactcaag atgcaataaa gcaactaggc atacacaaat taccatcggt tttggttttg     1080

caattgaaaa gattcgaaca cctacttaat ggaagtaaca gaaaactaga cgattttatt     1140

gaatttccaa cttatttaaa tatgaaaaat tactgttcaa cgaaggaaaa agataagcat     1200

tctgaaaatg gcaaggttcc agacattatt tacgaattaa tcggtattgt ttcccacaag     1260

gggacggtta atgagggaca ttatattgca ttttgtaaaa tttctggagg gcaatggttt     1320

aaattcaatg attccatggt ctcctctata tctcaagaag aggttttaaa ggaacaggca     1380

tatttattat tctacaccat tcgtcaagta aattga                               1416


<210>  11
<211>  1332
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Thr Glu Arg Ile Pro Ile Lys Asn Tyr Gln Arg Thr Asn Ala Lys 
1               5                   10                  15      


Ala Leu Leu Lys Leu Thr Glu Lys Leu Phe Asn Lys Asn Phe Phe Asp 
            20                  25                  30          


Leu Tyr Leu Thr Ser Gln Gln Leu Val Val Leu Glu Tyr Leu Leu Ser 
        35                  40                  45              


Ile Ser Ser Glu Glu Asp Lys Leu Lys Ala Trp Asp Tyr Phe Leu Lys 
    50                  55                  60                  


Gly Asn Ile Ala Leu Asn Val Glu Lys Ser Phe Pro Leu Thr Gln Glu 
65                  70                  75                  80  


Glu Glu His His Gly Ala Val Ser Pro Ala Val Asp Thr Arg Ser Asp 
                85                  90                  95      


Asp Val Ser Ser Gln Thr Ile Lys Asp Asn Asn Asn Thr Asn Thr Asn 
            100                 105                 110         


Thr Ser Ile Ser Asn Glu Asn His Val Glu Asn Glu Ile Glu Asp Lys 
        115                 120                 125             


Gly Asp Asn Ala Ile Ala Asn Glu Asp Asn Phe Val Asn Asn Asp Glu 
    130                 135                 140                 


Ser Asp Asn Val Glu Glu Asp Leu Phe Lys Leu Asp Leu Glu Asp Leu 
145                 150                 155                 160 


Lys Gln Gln Ile Ser Gly Thr Arg Phe Ile Gly Asn Leu Ser Leu Lys 
                165                 170                 175     


Ile Arg Tyr Val Leu Trp Gln Cys Ala Ile Asp Tyr Ile Tyr Cys Asp 
            180                 185                 190         


Arg Asn Glu Phe Gly Asp Glu Asn Asp Thr Glu Tyr Thr Leu Leu Asp 
        195                 200                 205             


Val Glu Glu Lys Glu Glu Glu Glu Ile Gly Lys Asn Glu Lys Pro Gln 
    210                 215                 220                 


Asn Lys Glu Gly Ile Ser Lys Phe Ala Glu Asp Glu Asp Tyr Asp Asp 
225                 230                 235                 240 


Glu Asp Glu Asn Tyr Asp Glu Asp Ser Thr Asp Val Lys Asn Val Asp 
                245                 250                 255     


Asp Pro Pro Lys Asn Leu Asp Ser Ile Ser Ser Ser Asn Ile Glu Ile 
            260                 265                 270         


Asp Asp Glu Arg Arg Leu Val Leu Asn Ile Ser Ile Ser Lys Glu Thr 
        275                 280                 285             


Leu Ser Lys Leu Lys Thr Asn Asn Val Glu Glu Ile Met Gly Asn Trp 
    290                 295                 300                 


Asn Lys Ile Tyr His Ser Phe Glu Tyr Asp Lys Glu Thr Met Ile Lys 
305                 310                 315                 320 


Arg Leu Lys Leu Glu Glu Ser Asp Lys Met Ile Glu Lys Gly Lys Lys 
                325                 330                 335     


Lys Arg Ser Arg Ser Asp Leu Glu Ala Ala Thr Asp Glu Gln Asp Arg 
            340                 345                 350         


Glu Asn Thr Asn Asp Glu Pro Asp Thr Asn Gln Lys Leu Pro Thr Pro 
        355                 360                 365             


Glu Gly Ser Thr Phe Ser Asp Thr Gly Asn Lys Arg Pro Lys Gln Ser 
    370                 375                 380                 


Asn Leu Asp Leu Thr Val Asn Leu Gly Ile Glu Asn Leu Ser Leu Lys 
385                 390                 395                 400 


His Leu Leu Ser Ser Ile Gln Gln Lys Lys Ser Gln Leu Gly Ile Ser 
                405                 410                 415     


Asp Tyr Glu Leu Lys His Leu Ile Met Asp Val Arg Lys Asn Arg Ser 
            420                 425                 430         


Lys Trp Thr Ser Asp Glu Arg Ile Gly Gln Glu Glu Leu Tyr Glu Ala 
        435                 440                 445             


Cys Glu Lys Val Val Leu Glu Leu Arg Asn Tyr Thr Glu His Ser Thr 
    450                 455                 460                 


Pro Phe Leu Asn Lys Val Ser Lys Arg Glu Ala Pro Asn Tyr His Gln 
465                 470                 475                 480 


Ile Ile Lys Lys Ser Met Asp Leu Asn Thr Val Leu Lys Lys Leu Lys 
                485                 490                 495     


Ser Phe Gln Tyr Asp Ser Lys Gln Glu Phe Val Asp Asp Ile Met Leu 
            500                 505                 510         


Ile Trp Lys Asn Cys Leu Thr Tyr Asn Ser Asp Pro Ser His Phe Leu 
        515                 520                 525             


Arg Gly His Ala Ile Ala Met Gln Lys Lys Ser Leu Gln Leu Ile Arg 
    530                 535                 540                 


Met Ile Pro Asn Ile Thr Ile Arg Asn Arg Ala Asp Leu Glu Lys Glu 
545                 550                 555                 560 


Ile Glu Asp Met Glu Lys Asp Lys Asp Tyr Glu Leu Asp Glu Glu Glu 
                565                 570                 575     


Glu Val Ala Gly Ser Gly Arg Lys Gly Leu Asn Met Gly Ala His Met 
            580                 585                 590         


Leu Ala Lys Glu Asn Gly Lys Val Ser Glu Lys Asp Ser Ser Lys Thr 
        595                 600                 605             


Val Lys Asp Glu Ala Pro Thr Asn Asp Asp Lys Leu Thr Ser Val Ile 
    610                 615                 620                 


Pro Glu Gly Glu Lys Glu Lys Asp Lys Thr Ala Ser Ser Thr Val Thr 
625                 630                 635                 640 


Val His Glu Asn Val Asn Lys Asn Glu Ile Lys Glu Asn Gly Lys Asn 
                645                 650                 655     


Glu Glu Gln Asp Met Val Glu Glu Ser Ser Lys Thr Glu Asp Ser Ser 
            660                 665                 670         


Lys Asp Ala Asp Ala Ala Lys Lys Asp Thr Glu Asp Gly Leu Gln Asp 
        675                 680                 685             


Lys Thr Ala Glu Asn Lys Glu Ala Gly Glu Asn Asn Glu Glu Glu Glu 
    690                 695                 700                 


Asp Asp Asp Asp Glu Asp Glu Asp Glu Asp Met Val Asp Ser Gln Ser 
705                 710                 715                 720 


Tyr Leu Leu Glu Lys Asp Asp Asp Arg Asp Asp Leu Glu Ile Ser Val 
                725                 730                 735     


Trp Lys Thr Val Thr Ala Lys Val Arg Ala Glu Ile Cys Leu Lys Arg 
            740                 745                 750         


Thr Glu Tyr Phe Lys Asn Gly Lys Leu Asn Ser Asp Ser Glu Ala Phe 
        755                 760                 765             


Leu Lys Asn Pro Gln Arg Met Lys Arg Phe Asp Gln Leu Phe Leu Glu 
    770                 775                 780                 


Tyr Lys Glu Gln Lys Ala Leu Glu Ser Tyr Arg Gln Lys Ile Glu Gln 
785                 790                 795                 800 


Asn Ser Ile Met Lys Asn Gly Phe Gly Thr Val Leu Lys Gln Glu Asp 
                805                 810                 815     


Asp Asp Gln Leu Gln Phe His Asn Asp His Ser Leu Asn Gly Asn Glu 
            820                 825                 830         


Ala Phe Glu Lys Gln Pro Asn Asp Ile Glu Leu Asp Asp Thr Arg Phe 
        835                 840                 845             


Leu Gln Glu Tyr Asp Ile Ser Asn Ala Ile Pro Asp Ile Val Tyr Glu 
    850                 855                 860                 


Gly Val Asn Thr Lys Thr Leu Asp Lys Met Glu Asp Ala Ser Val Asp 
865                 870                 875                 880 


Arg Met Leu Gln Asn Gly Ile Asn Lys Gln Ser Arg Phe Leu Ala Asn 
                885                 890                 895     


Lys Asp Leu Gly Leu Thr Pro Lys Met Asn Gln Asn Ile Thr Leu Ile 
            900                 905                 910         


Gln Gln Ile Arg His Ile Cys His Lys Ile Ser Leu Ile Arg Met Leu 
        915                 920                 925             


Gln Ser Pro Leu Ser Ala Gln Asn Ser Arg Ser Asn Pro Asn Ala Phe 
    930                 935                 940                 


Leu Asn Asn His Ile Tyr Asn Tyr Thr Ile Ile Asp Asp Ser Leu Asp 
945                 950                 955                 960 


Ile Asp Pro Val Ser Gln Leu Pro Thr His Asp Tyr Lys Asn Asn Arg 
                965                 970                 975     


Glu Leu Ile Trp Lys Phe Met His Lys Asn Ile Ser Lys Val Ala Met 
            980                 985                 990         


Ala Asn Gly Phe Glu Thr Ala His  Pro Ser Ala Ile Asn  Met Leu Thr 
        995                 1000                 1005             


Glu Ile  Ala Gly Asp Tyr Leu  Ser Asn Leu Ile Lys  Thr Leu Lys 
    1010                 1015                 1020             


Leu His  His Glu Thr Asn Ser  Leu Asn Arg Gly Thr  Asn Val Glu 
    1025                 1030                 1035             


Met Leu  Gln Thr Thr Leu Leu  Glu Asn Gly Ile Asn  Arg Pro Asp 
    1040                 1045                 1050             


Asp Leu  Phe Ser Tyr Val Glu  Ser Glu Phe Gly Lys  Lys Thr Lys 
    1055                 1060                 1065             


Lys Leu  Gln Asp Ile Lys Gln  Lys Leu Glu Ser Phe  Leu Arg Ala 
    1070                 1075                 1080             


Leu Leu  Arg Pro Thr Leu Gln  Glu Leu Ser Glu Arg  Asn Phe Glu 
    1085                 1090                 1095             


Asp Glu  Ser Gln Ser Phe Phe  Thr Gly Asp Phe Ala  Ser Glu Leu 
    1100                 1105                 1110             


Thr Gly  Glu Asp Phe Phe Gly  Phe Arg Glu Leu Gly  Leu Glu Lys 
    1115                 1120                 1125             


Glu Phe  Gly Val Leu Ser Ser  Ser Val Pro Leu Gln  Leu Leu Thr 
    1130                 1135                 1140             


Thr Gln  Phe Gln Thr Val Asp  Gly Glu Thr Lys Val  Gln Ala Lys 
    1145                 1150                 1155             


Lys Ile  Gln Pro Glu Glu Ser  Asp Ser Ile Val Tyr  Lys Lys Ile 
    1160                 1165                 1170             


Thr Lys  Gly Met Leu Asp Ala  Gly Ser Phe Trp Asn  Thr Leu Leu 
    1175                 1180                 1185             


Pro Leu  Leu Gln Lys Asp Tyr  Glu Arg Ser Lys Ala  Tyr Ile Ala 
    1190                 1195                 1200             


Lys Gln  Ser Lys Ser Ser Ala  Asn Asp Lys Thr Ser  Met Thr Ser 
    1205                 1210                 1215             


Thr Glu  Asp Asn Ser Phe Ala  Leu Leu Glu Glu Asp  Gln Phe Val 
    1220                 1225                 1230             


Ser Lys  Lys Thr Ala Thr Lys  Ala Arg Leu Pro Pro  Thr Gly Lys 
    1235                 1240                 1245             


Ile Ser  Thr Thr Tyr Lys Lys  Lys Pro Ile Ala Ser  Ala Phe Ile 
    1250                 1255                 1260             


Leu Pro  Glu Glu Asp Leu Glu  Asn Asp Val Lys Ala  Asp Pro Thr 
    1265                 1270                 1275             


Thr Thr  Val Asn Ala Lys Val  Gly Ala Glu Asn Asp  Gly Asp Ser 
    1280                 1285                 1290             


Ser Leu  Phe Leu Arg Thr Pro  Gln Pro Leu Asp Pro  Leu Asp Met 
    1295                 1300                 1305             


Asp Asp  Ala Phe Asp Asp Thr  Asn Met Gly Ser Asn  Ser Ser Phe 
    1310                 1315                 1320             


Ser Leu  Ser Leu Pro Arg Leu  Asn Gln 
    1325                 1330         


<210>  12
<211>  3999
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  12
atgactgaaa gaataccaat aaagaattat caaagaacaa atgccaaagc tttacttaaa       60

ttgactgaaa aactttttaa caagaacttt tttgatctct atttaacctc tcagcaattg      120

gtcgttcttg aatacctgct gtcgatttca agtgaagaag acaaactgaa agcatgggac      180

tatttcttaa agggaaacat agcattaaat gtcgaaaaat catttccatt aacccaagaa      240

gaagaacatc acggagcggt ctctcctgcc gttgacacac gatcagatga tgtatcatca      300

caaacaatta aggacaataa caatactaat accaacacca gtatcagcaa tgaaaatcat      360

gttgaaaatg aaattgaaga taaaggcgat aacgcaatag caaatgaaga taattttgtg      420

aataatgacg aaagtgataa tgttgaagaa gacttattca aattagatct agaggacttg      480

aagcagcaaa taagcggaac aaggtttatt ggaaacttat ccttgaaaat cagatacgtc      540

ttgtggcagt gcgccataga ttatatatac tgtgatcgta atgagtttgg tgatgaaaat      600

gatacagaat acaccctatt agatgttgaa gagaaggagg aagaggaaat tggtaaaaat      660

gagaagccac aaaacaaaga aggtatttcg aagttcgccg aggatgaaga ttacgacgat      720

gaagacgaga actatgatga agacagtaca gacgtaaaaa atgtcgatga tcctccaaaa      780

aatctcgatt ctatttcctc ttctaatatc gaaattgacg atgaacgacg cttggtgcta      840

aatatctcaa tatcaaaaga aacactgtca aagttaaaaa caaataatgt agaagaaatt      900

atgggaaatt ggaacaaaat ttaccacagt tttgaatacg ataaagaaac tatgataaag      960

cgattaaaac ttgaagaaag cgataaaatg atagagaaag gaaagaagaa acgaagtcga     1020

agtgatttag aagcagctac cgatgaacaa gatcgcgaaa atacaaatga tgagccagat     1080

actaatcaaa aattgcccac tcctgaaggt tcaacattca gcgatactgg gaacaagcgc     1140

cccaaacaaa gtaatttaga tttaacagtc aatctaggca tcgaaaattt atcattaaag     1200

caccttctat catctatcca gcaaaaaaaa tcccaattag gaatatcaga ttacgaatta     1260

aaacatctga ttatggatgt cagaaaaaat cggtcaaaat ggacatcgga tgaaagaatt     1320

gggcaagagg aattatacga agcctgtgaa aaggttgttt tggaacttag aaactacact     1380

gagcattcta caccatttct gaataaagtg agcaaaagag aagcccccaa ttatcatcaa     1440

atcatcaaaa agtccatgga cctgaatact gttttaaaaa aactgaaaag ctttcaatat     1500

gactccaaac aagaatttgt agacgatatt atgctaatat ggaaaaattg tttgacctat     1560

aattcagatc cttcacattt tttgagaggg catgctattg ctatgcagaa gaaatctctt     1620

cagttgattc gcatgattcc aaatatcaca atccgaaaca gggctgattt agaaaaggaa     1680

attgaagata tggaaaaaga caaagactac gaattagatg aggaagagga agttgctggt     1740

tctggaagaa aaggattgaa tatgggagct catatgttgg ccaaagagaa tggcaaggtg     1800

tcagaaaaag atagctctaa aaccgtcaag gatgaagcac caaccaatga tgacaaacta     1860

acttctgtca tccctgaggg ggaaaaagag aaagataaaa ctgcttcatc tactgtaacg     1920

gtacacgaaa atgtaaataa gaacgaaata aaagaaaatg ggaaaaatga agagcaagat     1980

atggttgagg aaagtagtaa gactgaggat tcatcaaaag atgctgatgc tgccaaaaag     2040

gatacggaag acggactaca agataaaact gcagaaaata aggaggctgg ggaaaataat     2100

gaagaggaag aggatgatga tgacgaagat gaagacgaag acatggtcga ctcccaatct     2160

tatttacttg aaaaggatga cgatagagac gatttggaaa tatccgtgtg gaaaactgta     2220

actgccaaag ttcgtgcgga aatttgctta aaaagaactg aatattttaa aaatggaaaa     2280

ttaaatagtg attcagaggc gtttttgaaa aacccacaaa gaatgaaaag gttcgaccag     2340

ctttttcttg aatataaaga gcagaaagct ttagaatcat atcgtcaaaa aatagagcaa     2400

aattccatta tgaaaaatgg ctttggaaca gtactaaaac aggaagacga tgaccaattg     2460

cagtttcata atgatcactc tttaaatgga aatgaagctt ttgaaaagca acccaatgat     2520

attgagttag atgataccag attcctacag gaatatgata ttagtaacgc cattcctgac     2580

atagtatacg agggagtaaa tactaaaaca ttagacaaga tggaagacgc ttccgtggac     2640

cgcatgcttc aaaatggtat caacaaacaa agcagatttc tggctaacaa ggatttagga     2700

ctaacaccta aaatgaacca aaatatcaca ctgattcagc aaattaggca catatgccat     2760

aaaatatccc tgatcagaat gttacagagc cctttatcgg ctcaaaactc cagaagcaat     2820

cccaacgctt tccttaacaa ccacatttat aattacacta ttattgatga ctcactcgat     2880

attgatccgg tgtcacagct tccaacgcat gattacaaaa acaacaggga gctgatatgg     2940

aaattcatgc ataagaacat atctaaggtt gctatggcca atgggtttga aactgcccat     3000

ccatcagcaa taaacatgct tactgaaatc gccggggatt acctatctaa tctgataaag     3060

actttgaagc ttcatcatga aactaactcc ttaaatagag gaacaaatgt ggaaatgctg     3120

caaacaacac tgttggaaaa cggtatcaac aggccagacg atctattttc ctatgttgaa     3180

tctgaatttg gtaaaaaaac taagaaactt caggacatca aacagaaact agaaagcttt     3240

ttgagagcct tattaaggcc aactttgcag gagttgtccg agagaaactt tgaagacgag     3300

agccaaagct tttttacagg tgactttgcc agcgaattga ctggtgaaga cttctttggt     3360

tttagagagc ttggattaga aaaggagttt ggagttttga gttcatctgt tccattacag     3420

ttactgacta ctcagtttca aactgttgac ggggaaacca aagtgcaggc caaaaagatc     3480

caaccggaag aatcagacag cattgtgtat aagaaaatta caaaaggtat gctggatgct     3540

ggttcattct ggaatactct acttccccta ttacaaaaag attatgaacg ttccaaggcc     3600

tatatagcaa agcaaagcaa gtcatctgca aatgataaaa cctcaatgac ttccacagaa     3660

gacaattctt tcgctttact agaagaggat cagtttgtct caaagaaaac cgcaacgaag     3720

gcaagattac ctcctactgg taagataagt accacataca aaaagaaacc gatcgcaagc     3780

gcgtttatac ttccagaaga agacttggaa aacgacgtaa aagcggatcc aacaacaact     3840

gtaaacgcca aagtgggtgc agaaaatgat ggagattctt ccttattttt gcgaacgcct     3900

caacctttag atcctttgga tatggatgat gcttttgatg ataccaatat gggcagcaat     3960

agttcattta gcttgagcct tcctcgcctt aatcaataa                            3999


<210>  13
<211>  602
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Asp Glu Val Asp Asp Ile Leu Ile Asn Asn Gln Val Val Asp Asp 
1               5                   10                  15      


Glu Glu Asp Asp Glu Glu Met Leu Ser Gly Leu Glu Asn Asp Ser Lys 
            20                  25                  30          


Gln Asp Leu Glu Gly Asn Asp Asp Gly Gly Glu Asp Glu Glu Asp Asp 
        35                  40                  45              


Asp Asp Asp Asp Glu Asp Asp Asp Asp Asp Glu Asp Glu Arg Glu Asp 
    50                  55                  60                  


Asp Asp Glu Gln Glu Asp Asp Asp Gly Glu Asp Asp Ala Ala Arg Met 
65                  70                  75                  80  


Asp Lys Thr Ala Thr Pro Thr Asn Glu His Gln His Asp Glu Gln Lys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ala Gly Gly Ala Gly Asp Ser Gly Asp Ala Val 
            100                 105                 110         


Thr Lys Ile Gly Ser Glu Asp Val Lys Leu Ser Asp Val Asp Gly Gly 
        115                 120                 125             


Val Gly Ser Arg Glu Ala Ser Ser Ser Thr His Glu Ala Ser Ala Asn 
    130                 135                 140                 


Gly Glu Val Tyr Glu Tyr Tyr Lys His Met Leu Asn Ala Ala Gln Ile 
145                 150                 155                 160 


Ala Asp Ser Tyr Asn Ile Tyr Pro Thr Ala Ala Ile Pro Ile Gln Thr 
                165                 170                 175     


His Val Asn Ala Leu Ala Val Ser Arg Gly Leu Lys Tyr Leu Phe Leu 
            180                 185                 190         


Gly Gly Ser Asp Gly Tyr Ile Arg Lys Tyr Asp Leu Leu Asn Thr Leu 
        195                 200                 205             


Glu Gly Lys Leu Ser Leu Thr Ile Leu Gln Lys His Ser Leu Ala Glu 
    210                 215                 220                 


Ser Ile Gln Asn Ala Gly Ile Leu Gln Ser Tyr Trp Glu Asn Glu Ile 
225                 230                 235                 240 


Pro Gln Lys Lys Ser Glu Met Lys Leu Ser Ala Asn Lys Thr Asp Tyr 
                245                 250                 255     


Glu Pro Lys Val Ser Pro Val His Ser Leu Glu Val Gln Ser Glu Cys 
            260                 265                 270         


Leu Phe Ile Leu Ser Gly Leu Gln Asn Gly Gly Ile Thr Met Gln Gly 
        275                 280                 285             


Val Arg Tyr Met Glu Gly Ser Ile Ala His Tyr Phe Lys Gly Arg Asn 
    290                 295                 300                 


Gly His Thr Gln Ile Val Asn Ile Leu Arg Leu Asn Gly Gln Glu Asp 
305                 310                 315                 320 


Arg Phe Leu Ser Gly Ser Trp Asp Lys Arg Leu Leu Glu Trp Asp Leu 
                325                 330                 335     


Gln Thr Gly Asp Ile Val Asn Glu Phe Lys Lys Ser Arg Ser Glu Leu 
            340                 345                 350         


Ser Ser Leu Glu Met Arg Pro Leu Tyr Ser Ser Val Asp Val Ser Gly 
        355                 360                 365             


Asn Val Asn Ser Gly Lys Glu Asn Glu Asn Ala Asp Asp Asp Met Asp 
    370                 375                 380                 


Ser Leu Phe Gly Asp Glu Asp Glu Asp Glu Lys Gln Asp Ala Gly Asn 
385                 390                 395                 400 


Glu Pro Val Glu Thr Gly Asp Gly Ser Asn Gly Glu Glu Asn Lys Glu 
                405                 410                 415     


Gln Ile Ser Glu Glu Ser Leu Asn Ile Val Tyr Asp Glu Ser Val Phe 
            420                 425                 430         


Met Thr Ser Gly Leu Asn Gly Ser Val His Ile Trp Asp Arg Arg Met 
        435                 440                 445             


Thr Gln Ser Pro Ala Leu Ser Leu Glu Arg Gly Ala Gly Val Pro Pro 
    450                 455                 460                 


Trp Cys Leu Ser Ala Cys Trp Gly Val Asp Gly Asp His Val Tyr Ala 
465                 470                 475                 480 


Gly Arg Arg Asn Ala Cys Val Glu Gln Phe Asp Leu Lys Met Pro Ser 
                485                 490                 495     


Lys Pro Ile His Asn Leu Lys Leu Pro Ser Ile Ser Gly Pro Val Ser 
            500                 505                 510         


Cys Val Lys Ala Met Pro Asn Asn Lys His Leu Leu Cys Ala Ser Arg 
        515                 520                 525             


Asp Asn Ile Arg Leu Tyr Asn Val Glu Ile Ala Val Asp Ala Ser Asn 
    530                 535                 540                 


Ser Thr Thr Lys Ser Ser Lys Val Pro Phe Leu Ile Val Pro Gly His 
545                 550                 555                 560 


His Gly Gly Ile Ile Ser Asn Leu Tyr Leu Asp Pro Thr Ser Arg Phe 
                565                 570                 575     


Ile Ile Ser Thr Ser Gly Asn Arg Gly Trp Gln Gly Asn Ser Thr Asp 
            580                 585                 590         


Thr Thr Leu Ile Tyr Asp Ile Asp Leu Glu 
        595                 600         


<210>  14
<211>  1809
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
atggacgagg ttgacgatat tctaattaac aaccaggtgg tggatgacga ggaggatgac       60

gaagagatgc tgagtgggct ggaaaacgac tcaaagcagg acctcgaggg gaatgatgac      120

ggtggtgaag atgaagagga tgacgatgat gatgatgagg acgatgatga tgacgaggac      180

gaacgagagg acgacgatga acaggaggac gacgatggtg aggacgacgc cgcaagaatg      240

gataagactg ctacaccgac gaatgagcac cagcatgatg agcaaaaggc tgctgctgct      300

ggtgctggcg gtgcaggcga tagtggcgat gctgttacta agattggatc cgaggatgtg      360

aaattgagcg atgttgatgg aggagtgggg tccagggaag catcttcctc tacacacgaa      420

gcctctgcta atggagaggt ttatgagtac tataagcaca tgttgaatgc cgcacagatt      480

gcggattcgt acaatatcta ccccacggca gccataccca tccagacgca cgtcaatgcg      540

ttggccgtgt ccaggggtct caagtacctg tttttgggcg gtagcgatgg atacataagg      600

aagtacgact tgctgaacac gcttgagggg aaactttctc taactatcct gcagaagcat      660

tcgttggctg agtctattca gaacgcgggt atcttgcagt cgtactggga aaatgagatc      720

ccgcagaaaa aatcagaaat gaaactctcc gctaataaga cagattacga gcccaaagtt      780

agccccgttc attctttgga agtccaaagc gaatgcctct ttatactgag cgggctacag      840

aatggtggga ttaccatgca gggcgttcgc tacatggagg ggagcattgc gcactatttt      900

aagggcagga atggacatac ccaaatcgtt aacatactga gattaaacgg tcaagaggac      960

aggtttttga gtggttcctg ggataagcgt cttttggaat gggatttgca gacgggtgac     1020

atagttaatg agtttaaaaa atcaaggtct gaattgtcat ctttggaaat gcggccgctg     1080

tactcgtccg tggatgtgtc cggtaacgtc aacagtggta aagagaatga aaatgcagat     1140

gacgatatgg attctctgtt tggtgatgaa gacgaagacg aaaagcaaga tgctggcaac     1200

gaacccgtcg agacggggga tggttctaat ggtgaagaga acaaagaaca gatatctgaa     1260

gaatctttga acatagtcta tgatgaatcc gtttttatga cctcagggtt gaacggttcc     1320

gtgcatattt gggaccgacg catgacgcag tcgccagcat tgtctctgga gagaggtgca     1380

ggcgtcccac cgtggtgttt gtccgcatgt tggggtgtag atggtgatca tgtgtatgca     1440

gggagaagga atgcctgtgt ggagcagttt gacttgaaga tgccctcgaa acctatccat     1500

aatttgaaac tgccttctat ttcagggcct gtctcttgtg ttaaagccat gcctaataac     1560

aagcatttac tatgtgcatc gcgggataat atcagattgt acaacgttga aattgcagta     1620

gatgcttcga attcgactac aaagagttct aaagtgccgt tcctcatcgt gccgggccat     1680

cacggtggta ttatatcaaa cttatacctc gaccccactt caagatttat aataagcaca     1740

agtggcaaca gaggctggca ggggaattct acggacacga cccttattta cgatatagac     1800

ttagaatag                                                             1809


<210>  15
<211>  633
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Ser Ser Asn Asn Asn Thr Asn Thr Ala Pro Ala Asn Ala Asn Ser 
1               5                   10                  15      


Ser His His His His His His His His His His His His His Gly His 
            20                  25                  30          


Gly Gly Ser Asn Ser Thr Leu Asn Asn Pro Lys Ser Ser Leu Ala Asp 
        35                  40                  45              


Gly Ala His Ile Gly Asn Tyr Gln Ile Val Lys Thr Leu Gly Glu Gly 
    50                  55                  60                  


Ser Phe Gly Lys Val Lys Leu Ala Tyr His Thr Thr Thr Gly Gln Lys 
65                  70                  75                  80  


Val Ala Leu Lys Ile Ile Asn Lys Lys Val Leu Ala Lys Ser Asp Met 
                85                  90                  95      


Gln Gly Arg Ile Glu Arg Glu Ile Ser Tyr Leu Arg Leu Leu Arg His 
            100                 105                 110         


Pro His Ile Ile Lys Leu Tyr Asp Val Ile Lys Ser Lys Asp Glu Ile 
        115                 120                 125             


Ile Met Val Ile Glu Tyr Ala Gly Asn Glu Leu Phe Asp Tyr Ile Val 
    130                 135                 140                 


Gln Arg Asp Lys Met Ser Glu Gln Glu Ala Arg Arg Phe Phe Gln Gln 
145                 150                 155                 160 


Ile Ile Ser Ala Val Glu Tyr Cys His Arg His Lys Ile Val His Arg 
                165                 170                 175     


Asp Leu Lys Pro Glu Asn Leu Leu Leu Asp Glu His Leu Asn Val Lys 
            180                 185                 190         


Ile Ala Asp Phe Gly Leu Ser Asn Ile Met Thr Asp Gly Asn Phe Leu 
        195                 200                 205             


Lys Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Ala Gly Pro Glu Val Asp Val Trp Ser Cys Gly Val 
225                 230                 235                 240 


Ile Leu Tyr Val Met Leu Cys Arg Arg Leu Pro Phe Asp Asp Glu Ser 
                245                 250                 255     


Ile Pro Val Leu Phe Lys Asn Ile Ser Asn Gly Val Tyr Thr Leu Pro 
            260                 265                 270         


Lys Phe Leu Ser Pro Gly Ala Ala Gly Leu Ile Lys Arg Met Leu Ile 
        275                 280                 285             


Val Asn Pro Leu Asn Arg Ile Ser Ile His Glu Ile Met Gln Asp Asp 
    290                 295                 300                 


Trp Phe Lys Val Asp Leu Pro Glu Tyr Leu Leu Pro Pro Asp Leu Lys 
305                 310                 315                 320 


Pro His Pro Glu Glu Glu Asn Glu Asn Asn Asp Ser Lys Lys Asp Gly 
                325                 330                 335     


Ser Ser Pro Asp Asn Asp Glu Ile Asp Asp Asn Leu Val Asn Ile Leu 
            340                 345                 350         


Ser Ser Thr Met Gly Tyr Glu Lys Asp Glu Ile Tyr Glu Ser Leu Glu 
        355                 360                 365             


Ser Ser Glu Asp Thr Pro Ala Phe Asn Glu Ile Arg Asp Ala Tyr Met 
    370                 375                 380                 


Leu Ile Lys Glu Asn Lys Ser Leu Ile Lys Asp Met Lys Ala Asn Lys 
385                 390                 395                 400 


Ser Val Ser Asp Glu Leu Asp Thr Phe Leu Ser Gln Ser Pro Pro Thr 
                405                 410                 415     


Phe Gln Gln Gln Ser Lys Ser His Gln Lys Ser Gln Val Asp His Glu 
            420                 425                 430         


Thr Ala Lys Gln His Ala Arg Arg Met Ala Ser Ala Ile Thr Gln Gln 
        435                 440                 445             


Arg Thr Tyr His Gln Ser Pro Phe Met Asp Gln Tyr Lys Glu Glu Asp 
    450                 455                 460                 


Ser Thr Val Ser Ile Leu Pro Thr Ser Leu Pro Gln Ile His Arg Ala 
465                 470                 475                 480 


Asn Met Leu Ala Gln Gly Ser Pro Ala Ala Ser Lys Ile Ser Pro Leu 
                485                 490                 495     


Val Thr Lys Lys Ser Lys Thr Arg Trp His Phe Gly Ile Arg Ser Arg 
            500                 505                 510         


Ser Tyr Pro Leu Asp Val Met Gly Glu Ile Tyr Ile Ala Leu Lys Asn 
        515                 520                 525             


Leu Gly Ala Glu Trp Ala Lys Pro Ser Glu Glu Asp Leu Trp Thr Ile 
    530                 535                 540                 


Lys Leu Arg Trp Lys Tyr Asp Ile Gly Asn Lys Thr Asn Thr Asn Glu 
545                 550                 555                 560 


Lys Ile Pro Asp Leu Met Lys Met Val Ile Gln Leu Phe Gln Ile Glu 
                565                 570                 575     


Thr Asn Asn Tyr Leu Val Asp Phe Lys Phe Asp Gly Trp Glu Ser Ser 
            580                 585                 590         


Tyr Gly Asp Asp Thr Thr Val Ser Asn Ile Ser Glu Asp Glu Met Ser 
        595                 600                 605             


Thr Phe Ser Ala Tyr Pro Phe Leu His Leu Thr Thr Lys Leu Ile Met 
    610                 615                 620                 


Glu Leu Ala Val Asn Ser Gln Ser Asn 
625                 630             


<210>  16
<211>  1902
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  16
atgagcagta acaacaacac aaacacagca cctgccaatg caaattctag ccaccaccac       60

caccatcacc accatcacca ccaccatcac ggtcatggcg gaagcaactc gacgctaaac      120

aatcccaagt cgtccttagc ggatggtgca catatcggga actaccaaat cgtcaaaacg      180

ctgggagagg ggtcctttgg taaagttaaa ttggcatatc ataccactac gggccaaaaa      240

gttgctctaa aaatcattaa taagaaggtt ttggcaaaga gtgatatgca gggcagaatt      300

gaaagagaaa tatcttatct gagactctta agacaccccc acatcatcaa actgtatgat      360

gttatcaaat ccaaagatga aatcattatg gttatagagt acgccgggaa cgaattgttt      420

gactatattg ttcagagaga caaaatgagc gagcaagagg caagaagatt tttccagcag      480

atcatcagtg ccgtcgagta ctgccatagg cacaaaattg tccatagaga tctgaagcct      540

gaaaacttac tactagatga gcatctgaat gtaaagattg ccgattttgg tttgtcaaac      600

atcatgactg atggtaattt cttaaagact tcttgtggtt ctcccaatta tgcggctcct      660

gaagttatca gcggtaagct gtacgcaggc ccagaagtgg acgtgtggtc atgtggggtt      720

atcctttatg ttatgctttg tcgtcgtcta ccgtttgacg atgaaagcat cccagtgctt      780

ttcaagaata tcagcaacgg tgtttacacc ttgcctaaat ttttatctcc tggagctgct      840

gggctaatca aaagaatgtt aatcgttaat ccattgaaca gaataagcat tcatgaaatt      900

atgcaagacg attggttcaa agttgacctg ccagaatatc tacttccacc agatttgaaa      960

ccacacccag aagaagagaa tgaaaataat gactcaaaaa aggatggcag cagcccagat     1020

aacgatgaaa ttgatgacaa ccttgtcaat attttatcat cgaccatggg ttacgaaaaa     1080

gacgagattt atgagtcctt agaatcatca gaagacactc ctgcattcaa cgaaattagg     1140

gacgcgtaca tgttgattaa ggagaataaa tctttgatca aggatatgaa ggcaaacaaa     1200

agcgtcagtg atgaactgga tacctttctg tcccagtcac ctccaacttt tcaacaacaa     1260

agcaaatccc atcaaaagag tcaagtagat catgaaactg ccaagcaaca cgcaagaagg     1320

atggcaagtg ctatcactca acaaaggaca tatcaccaat cacccttcat ggatcagtat     1380

aaagaagaag actctacagt ttccattttg cctacatctt tacctcagat ccacagagct     1440

aatatgttag cacaaggttc gccagctgcc tctaaaatat ctcctcttgt aacgaaaaaa     1500

tctaaaacga gatggcattt tggtatacga tctcgctcat atccattaga cgttatgggt     1560

gaaatttata ttgccttgaa gaatttgggt gccgaatggg ccaagccatc tgaagaggat     1620

ttatggacta tcaaattaag gtggaaatat gatattggaa acaagacaaa cactaatgaa     1680

aaaatacctg atttaatgaa aatggtaatt caattatttc aaattgaaac caataattat     1740

ttggtggatt tcaaatttga cggctgggaa agtagttatg gagatgatac tactgtttct     1800

aatatttctg aagatgaaat gagtactttt tcagcctacc catttttaca tttaacaaca     1860

aaactaatta tggaattagc cgttaacagt caaagcaatt ga                        1902


<210>  17
<211>  713
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Pro Ser Ala Val Gln Ser Ser Lys Leu Glu Glu Gln Ser Ser 
1               5                   10                  15      


Glu Ile Asp Lys Leu Lys Ala Lys Met Ser Gln Ser Ala Ala Thr Ala 
            20                  25                  30          


Gln Arg Lys Lys Glu His Glu Tyr Glu His Leu Thr Ser Val Lys Ile 
        35                  40                  45              


Val Pro Gln Arg Pro Ile Ser Asp Arg Leu Gln Pro Ala Ile Ala Thr 
    50                  55                  60                  


His Tyr Ser Pro His Leu Asp Gly Leu Gln Asp Tyr Gln Arg Leu His 
65                  70                  75                  80  


Lys Glu Ser Ile Glu Asp Pro Ala Lys Phe Phe Gly Ser Lys Ala Thr 
                85                  90                  95      


Gln Phe Leu Asn Trp Ser Lys Pro Phe Asp Lys Val Phe Ile Pro Asp 
            100                 105                 110         


Pro Lys Thr Gly Arg Pro Ser Phe Gln Asn Asn Ala Trp Phe Leu Asn 
        115                 120                 125             


Gly Gln Leu Asn Ala Cys Tyr Asn Cys Val Asp Arg His Ala Leu Lys 
    130                 135                 140                 


Thr Pro Asn Lys Lys Ala Ile Ile Phe Glu Gly Asp Glu Pro Gly Gln 
145                 150                 155                 160 


Gly Tyr Ser Ile Thr Tyr Lys Glu Leu Leu Glu Glu Val Cys Gln Val 
                165                 170                 175     


Ala Gln Val Leu Thr Tyr Ser Met Gly Val Arg Lys Gly Asp Thr Val 
            180                 185                 190         


Ala Val Tyr Met Pro Met Val Pro Glu Ala Ile Ile Thr Leu Leu Ala 
        195                 200                 205             


Ile Ser Arg Ile Gly Ala Ile His Ser Val Val Phe Ala Gly Phe Ser 
    210                 215                 220                 


Ser Asn Ser Leu Arg Asp Arg Ile Asn Asp Gly Asp Ser Lys Val Val 
225                 230                 235                 240 


Ile Thr Thr Asp Glu Ser Asn Arg Gly Gly Lys Val Ile Glu Thr Lys 
                245                 250                 255     


Arg Ile Val Asp Asp Ala Leu Arg Glu Thr Pro Gly Val Arg His Val 
            260                 265                 270         


Leu Val Tyr Arg Lys Thr Asn Asn Pro Ser Val Ala Phe His Ala Pro 
        275                 280                 285             


Arg Asp Leu Asp Trp Ala Thr Glu Lys Lys Lys Tyr Lys Thr Tyr Tyr 
    290                 295                 300                 


Pro Cys Thr Pro Val Asp Ser Glu Asp Pro Leu Phe Leu Leu Tyr Thr 
305                 310                 315                 320 


Ser Gly Ser Thr Gly Ala Pro Lys Gly Val Gln His Ser Thr Ala Gly 
                325                 330                 335     


Tyr Leu Leu Gly Ala Leu Leu Thr Met Arg Tyr Thr Phe Asp Thr His 
            340                 345                 350         


Gln Glu Asp Val Phe Phe Thr Ala Gly Asp Ile Gly Trp Ile Thr Gly 
        355                 360                 365             


His Thr Tyr Val Val Tyr Gly Pro Leu Leu Tyr Gly Cys Ala Thr Leu 
    370                 375                 380                 


Val Phe Glu Gly Thr Pro Ala Tyr Pro Asn Tyr Ser Arg Tyr Trp Asp 
385                 390                 395                 400 


Ile Ile Asp Glu His Lys Val Thr Gln Phe Tyr Val Ala Pro Thr Ala 
                405                 410                 415     


Leu Arg Leu Leu Lys Arg Ala Gly Asp Ser Tyr Ile Glu Asn His Ser 
            420                 425                 430         


Leu Lys Ser Leu Arg Cys Leu Gly Ser Val Gly Glu Pro Ile Ala Ala 
        435                 440                 445             


Glu Val Trp Glu Trp Tyr Ser Glu Lys Ile Gly Lys Asn Glu Ile Pro 
    450                 455                 460                 


Ile Val Asp Thr Tyr Trp Gln Thr Glu Ser Gly Ser His Leu Val Thr 
465                 470                 475                 480 


Pro Leu Ala Gly Gly Val Thr Pro Met Lys Pro Gly Ser Ala Ser Phe 
                485                 490                 495     


Pro Phe Phe Gly Ile Asp Ala Val Val Leu Asp Pro Asn Thr Gly Glu 
            500                 505                 510         


Glu Leu Asn Thr Ser His Ala Glu Gly Val Leu Ala Val Lys Ala Ala 
        515                 520                 525             


Trp Pro Ser Phe Ala Arg Thr Ile Trp Lys Asn His Asp Arg Tyr Leu 
    530                 535                 540                 


Asp Thr Tyr Leu Asn Pro Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly 
545                 550                 555                 560 


Ala Ala Lys Asp Lys Asp Gly Tyr Ile Trp Ile Leu Gly Arg Val Asp 
                565                 570                 575     


Asp Val Val Asn Val Ser Gly His Arg Leu Ser Thr Ala Glu Ile Glu 
            580                 585                 590         


Ala Ala Ile Ile Glu Asp Pro Ile Val Ala Glu Cys Ala Val Val Gly 
        595                 600                 605             


Phe Asn Asp Asp Leu Thr Gly Gln Ala Val Ala Ala Phe Val Val Leu 
    610                 615                 620                 


Lys Asn Lys Ser Ser Trp Ser Thr Ala Thr Asp Asp Glu Leu Gln Asp 
625                 630                 635                 640 


Ile Lys Lys His Leu Val Phe Thr Val Arg Lys Asp Ile Gly Pro Phe 
                645                 650                 655     


Ala Ala Pro Lys Leu Ile Ile Leu Val Asp Asp Leu Pro Lys Thr Arg 
            660                 665                 670         


Ser Gly Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Leu Ala Gly Glu 
        675                 680                 685             


Ser Asp Gln Leu Gly Asp Val Ser Thr Leu Ser Asn Pro Gly Ile Val 
    690                 695                 700                 


Arg His Leu Ile Asp Ser Val Lys Leu 
705                 710             


<210>  18
<211>  2142
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  18
atgtcgccct ctgccgtaca atcatcaaaa ctagaagaac agtcaagtga aattgacaag       60

ttgaaagcaa aaatgtccca gtctgccgcc actgcgcagc agaagaagga acatgagtat      120

gaacatttga cttcggtcaa gatcgtgcca caacggccca tctcagatag actgcagccc      180

gcaattgcta cccactattc tccacacttg gacgggttgc aggactatca gcgcttgcac      240

aaggagtcta ttgaagaccc tgctaagttc ttcggttcta aagctaccca atttttaaac      300

tggtctaagc cattcgataa ggtgttcatc ccagacccta aaacgggcag gccctccttc      360

cagaacaatg catggttcct caacggccaa ttaaacgcct gttacaactg tgttgacaga      420

catgccttga agactcctaa caagaaagcc attattttcg aaggtgacga gcctggccaa      480

ggctattcca ttacctacaa ggaactactt gaagaagttt gtcaagtggc acaagtgctg      540

acttactcta tgggcgttcg caagggcgat actgttgccg tgtacatgcc tatggtccca      600

gaagcaatca taaccttgtt ggccatttcc cgtatcggtg ccattcactc cgtagtcttt      660

gccgggtttt cttccaactc cttgagagat cgtatcaacg atggggactc taaagttgtc      720

atcactacag atgaatccaa cagaggtggt aaagtcattg agactaaaag aattgttgat      780

gacgcgctaa gagagacccc aggcgtgaga cacgtcttgg tttatagaaa gaccaacaat      840

ccatctgttg ctttccatgc ccccagagat ttggattggg caacagaaaa gaagaaatac      900

aagacctact atccatgcac acccgttgat tctgaggatc cattattctt gttgtatacg      960

tctggttcta ctggtgcccc caagggtgtt caacattcta ccgcaggtta cttgctggga     1020

gctttgttga ccatgcgcta cacttttgac actcaccaag aagacgtttt cttcacagct     1080

ggagacattg gctggattac aggccacact tatgtggttt atggtccctt actatatggt     1140

tgtgccactt tggtctttga agggactcct gcgtacccaa attactcccg ttattgggat     1200

attattgatg aacacaaagt cacccaattt tatgttgcgc caactgcttt gcgtttgttg     1260

aaaagagctg gtgattccta catcgaaaat cattccttaa aatctttgcg ttgcttgggt     1320

tcggtcggtg agccaattgc tgctgaagtt tgggagtggt actctgaaaa aataggtaaa     1380

aatgaaatcc ccattgtaga cacctactgg caaacagaat ctggttcgca tctggtcacc     1440

ccgctggctg gtggtgttac accaatgaaa ccgggttctg cctcattccc cttcttcggt     1500

attgatgcag ttgttcttga ccctaacact ggtgaagaac ttaacaccag ccacgcagag     1560

ggtgtccttg ccgtcaaagc tgcatggcca tcatttgcaa gaactatttg gaaaaatcat     1620

gataggtatc tagacactta tttgaaccct taccctggct actatttcac tggtgatggt     1680

gctgcaaagg ataaggatgg ttatatctgg attttgggtc gtgtagacga tgtggtgaac     1740

gtctctggtc accgtctgtc taccgctgaa attgaggctg ctattatcga agatccaatt     1800

gtggccgagt gtgctgttgt cggattcaac gatgacttga ctggtcaagc agttgctgca     1860

tttgtggtgt tgaaaaacaa atctagttgg tccaccgcaa cagatgatga attacaagat     1920

atcaagaagc atttggtctt tactgttaga aaagacatcg ggccatttgc cgcaccaaaa     1980

ttgatcattt tagtggatga cttgcccaag acaagatccg gcaaaattat gagacgtatt     2040

ttaagaaaaa tcctagcagg agaaagtgac caactaggcg acgtttctac attgtcaaac     2100

cctggcattg ttagacatct aattgattcg gtcaagttgt aa                        2142


<210>  19
<211>  1119
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Thr Glu Arg Ile Pro Ile Lys Asn Tyr Gln Arg Thr Asn Ala Lys 
1               5                   10                  15      


Ala Leu Leu Lys Leu Thr Glu Lys Leu Phe Asn Lys Asn Phe Phe Asp 
            20                  25                  30          


Leu Tyr Leu Thr Ser Gln Gln Leu Val Val Leu Glu Tyr Leu Leu Ser 
        35                  40                  45              


Ile Ser Ser Glu Glu Asp Lys Leu Lys Ala Trp Asp Tyr Phe Leu Lys 
    50                  55                  60                  


Gly Asn Ile Ala Leu Asn Val Glu Lys Ser Phe Pro Leu Thr Gln Glu 
65                  70                  75                  80  


Glu Glu His His Gly Ala Val Ser Pro Ala Val Asp Thr Arg Ser Asp 
                85                  90                  95      


Asp Val Ser Ser Gln Thr Ile Lys Asp Asn Asn Asn Thr Asn Thr Asn 
            100                 105                 110         


Thr Ser Ile Ser Asn Glu Asn His Val Glu Asn Glu Ile Glu Asp Lys 
        115                 120                 125             


Gly Asp Asn Ala Ile Ala Asn Glu Asp Asn Phe Val Asn Asn Asp Glu 
    130                 135                 140                 


Ser Asp Asn Val Glu Glu Asp Leu Phe Lys Leu Asp Leu Glu Asp Leu 
145                 150                 155                 160 


Lys Gln Gln Ile Ser Gly Thr Arg Phe Ile Gly Asn Leu Ser Leu Lys 
                165                 170                 175     


Ile Arg Tyr Val Leu Trp Gln Cys Ala Ile Asp Tyr Ile Tyr Cys Asp 
            180                 185                 190         


Arg Asn Glu Phe Gly Asp Glu Asn Asp Thr Glu Tyr Thr Leu Leu Asp 
        195                 200                 205             


Val Glu Glu Lys Glu Glu Glu Glu Ile Gly Lys Asn Glu Lys Pro Gln 
    210                 215                 220                 


Asn Lys Glu Gly Ile Ser Lys Phe Ala Glu Asp Glu Asp Tyr Asp Asp 
225                 230                 235                 240 


Glu Asp Glu Asn Tyr Asp Glu Asp Ser Thr Asp Val Lys Asn Val Asp 
                245                 250                 255     


Asp Pro Pro Lys Asn Leu Asp Ser Ile Ser Ser Ser Asn Ile Glu Ile 
            260                 265                 270         


Asp Asp Glu Arg Arg Leu Val Leu Asn Ile Ser Ile Ser Lys Glu Thr 
        275                 280                 285             


Leu Ser Lys Leu Lys Thr Asn Asn Val Glu Glu Ile Met Gly Asn Trp 
    290                 295                 300                 


Asn Lys Ile Tyr His Ser Phe Glu Tyr Asp Lys Glu Thr Met Ile Lys 
305                 310                 315                 320 


Arg Leu Lys Leu Glu Glu Ser Asp Lys Met Ile Glu Lys Gly Lys Lys 
                325                 330                 335     


Lys Arg Ser Arg Ser Asp Leu Glu Ala Ala Thr Asp Glu Gln Asp Arg 
            340                 345                 350         


Glu Asn Thr Asn Asp Glu Pro Asp Thr Asn Gln Lys Leu Pro Thr Pro 
        355                 360                 365             


Glu Gly Ser Thr Phe Ser Asp Thr Gly Asn Lys Arg Pro Lys Gln Ser 
    370                 375                 380                 


Asn Leu Asp Leu Thr Val Asn Leu Gly Ile Glu Asn Leu Ser Leu Lys 
385                 390                 395                 400 


His Leu Leu Ser Ser Ile Gln Gln Lys Lys Ser Gln Leu Gly Ile Ser 
                405                 410                 415     


Asp Tyr Glu Leu Lys His Leu Ile Met Asp Val Arg Lys Asn Arg Ser 
            420                 425                 430         


Lys Trp Thr Ser Asp Glu Arg Ile Gly Gln Glu Glu Leu Tyr Glu Ala 
        435                 440                 445             


Cys Glu Lys Val Val Leu Glu Leu Arg Asn Tyr Thr Glu His Ser Thr 
    450                 455                 460                 


Pro Phe Leu Asn Lys Val Ser Lys Arg Glu Ala Pro Asn Tyr His Gln 
465                 470                 475                 480 


Ile Ile Lys Lys Ser Met Asp Leu Asn Thr Val Leu Lys Lys Leu Lys 
                485                 490                 495     


Ser Phe Gln Tyr Asp Ser Lys Gln Glu Phe Val Asp Asp Ile Met Leu 
            500                 505                 510         


Ile Trp Lys Asn Cys Leu Thr Tyr Asn Ser Asp Pro Ser His Phe Leu 
        515                 520                 525             


Arg Gly His Ala Ile Ala Met Gln Lys Lys Ser Leu Gln Leu Ile Arg 
    530                 535                 540                 


Met Ile Pro Asn Ile Thr Ile Arg Asn Arg Ala Asp Leu Glu Lys Glu 
545                 550                 555                 560 


Ile Glu Asp Met Glu Lys Asp Lys Asp Tyr Glu Leu Asp Glu Glu Glu 
                565                 570                 575     


Glu Val Ala Gly Ser Gly Arg Lys Gly Leu Asn Met Gly Ala His Met 
            580                 585                 590         


Leu Ala Lys Glu Asn Gly Lys Val Ser Glu Lys Asp Ser Ser Lys Thr 
        595                 600                 605             


Val Lys Asp Glu Ala Pro Thr Asn Asp Asp Lys Leu Thr Ser Val Ile 
    610                 615                 620                 


Pro Glu Gly Glu Lys Glu Lys Asp Lys Thr Ala Ser Ser Thr Val Thr 
625                 630                 635                 640 


Val His Glu Asn Val Asn Lys Asn Glu Ile Lys Glu Asn Gly Lys Asn 
                645                 650                 655     


Glu Glu Gln Asp Met Val Glu Glu Ser Ser Lys Thr Glu Asp Ser Ser 
            660                 665                 670         


Lys Asp Ala Asp Ala Ala Lys Lys Asp Thr Glu Asp Gly Leu Gln Asp 
        675                 680                 685             


Lys Thr Ala Glu Asn Lys Glu Ala Gly Glu Asn Asn Glu Glu Glu Glu 
    690                 695                 700                 


Asp Asp Asp Asp Glu Asp Glu Asp Glu Asp Met Val Asp Ser Gln Ser 
705                 710                 715                 720 


Tyr Leu Leu Glu Lys Asp Asp Asp Arg Asp Asp Leu Glu Ile Ser Val 
                725                 730                 735     


Trp Lys Thr Val Thr Ala Lys Val Arg Ala Glu Ile Cys Leu Lys Arg 
            740                 745                 750         


Thr Glu Tyr Phe Lys Asn Gly Lys Leu Asn Ser Asp Ser Glu Ala Phe 
        755                 760                 765             


Leu Lys Asn Pro Gln Arg Met Lys Arg Phe Asp Gln Leu Phe Leu Glu 
    770                 775                 780                 


Tyr Lys Glu Gln Lys Ala Leu Glu Ser Tyr Arg Gln Lys Ile Glu Gln 
785                 790                 795                 800 


Asn Ser Ile Met Lys Asn Gly Phe Gly Thr Val Leu Lys Gln Glu Asp 
                805                 810                 815     


Asp Asp Gln Leu Gln Phe His Asn Asp His Ser Leu Asn Gly Asn Glu 
            820                 825                 830         


Ala Phe Glu Lys Gln Pro Asn Asp Ile Glu Leu Asp Asp Thr Arg Phe 
        835                 840                 845             


Leu Gln Glu Tyr Asp Ile Ser Asn Ala Ile Pro Asp Ile Val Tyr Glu 
    850                 855                 860                 


Gly Val Asn Thr Lys Thr Leu Asp Lys Met Glu Asp Ala Ser Val Asp 
865                 870                 875                 880 


Arg Met Leu Gln Asn Gly Ile Asn Lys Gln Ser Arg Phe Leu Ala Asn 
                885                 890                 895     


Lys Asp Leu Gly Leu Thr Pro Lys Met Asn Gln Asn Ile Thr Leu Ile 
            900                 905                 910         


Gln Gln Ile Arg His Ile Cys His Lys Ile Ser Leu Ile Arg Met Leu 
        915                 920                 925             


Gln Ser Pro Leu Ser Ala Gln Asn Ser Arg Ser Asn Pro Asn Ala Phe 
    930                 935                 940                 


Leu Asn Asn His Ile Tyr Asn Tyr Thr Ile Ile Asp Asp Ser Leu Asp 
945                 950                 955                 960 


Ile Asp Pro Val Ser Gln Leu Pro Thr His Asp Tyr Lys Asn Asn Arg 
                965                 970                 975     


Glu Leu Ile Trp Lys Phe Met His Lys Asn Ile Ser Lys Val Ala Met 
            980                 985                 990         


Ala Asn Gly Phe Glu Thr Ala His  Pro Ser Ala Ile Asn  Met Leu Thr 
        995                 1000                 1005             


Glu Ile  Ala Gly Asp Tyr Leu  Ser Asn Leu Ile Lys  Thr Leu Lys 
    1010                 1015                 1020             


Leu His  His Glu Thr Asn Ser  Leu Asn Arg Gly Thr  Asn Val Glu 
    1025                 1030                 1035             


Met Leu  Gln Thr Thr Leu Leu  Glu Asn Gly Ile Asn  Arg Pro Asp 
    1040                 1045                 1050             


Asp Leu  Phe Ser Tyr Val Glu  Ser Glu Phe Gly Lys  Lys Thr Lys 
    1055                 1060                 1065             


Lys Leu  Gln Asp Ile Lys Gln  Lys Leu Glu Ser Phe  Leu Arg Ala 
    1070                 1075                 1080             


Leu Leu  Arg Pro Thr Leu Gln  Glu Leu Ser Glu Arg  Asn Phe Glu 
    1085                 1090                 1095             


Asp Glu  Ser Gln Ser Phe Phe  Thr Gly Asp Phe Ala  Ser Glu Leu 
    1100                 1105                 1110             


Thr Gly  Glu Asp Phe Phe 
    1115                 


<210>  20
<211>  3357
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  20
atgactgaaa gaataccaat aaagaattat caaagaacaa atgccaaagc tttacttaaa       60

ttgactgaaa aactttttaa caagaacttt tttgatctct atttaacctc tcagcaattg      120

gtcgttcttg aatacctgct gtcgatttca agtgaagaag acaaactgaa agcatgggac      180

tatttcttaa agggaaacat agcattaaat gtcgaaaaat catttccatt aacccaagaa      240

gaagaacatc acggagcggt ctctcctgcc gttgacacac gatcagatga tgtatcatca      300

caaacaatta aggacaataa caatactaat accaacacca gtatcagcaa tgaaaatcat      360

gttgaaaatg aaattgaaga taaaggcgat aacgcaatag caaatgaaga taattttgtg      420

aataatgacg aaagtgataa tgttgaagaa gacttattca aattagatct agaggacttg      480

aagcagcaaa taagcggaac aaggtttatt ggaaacttat ccttgaaaat cagatacgtc      540

ttgtggcagt gcgccataga ttatatatac tgtgatcgta atgagtttgg tgatgaaaat      600

gatacagaat acaccctatt agatgttgaa gagaaggagg aagaggaaat tggtaaaaat      660

gagaagccac aaaacaaaga aggtatttcg aagttcgccg aggatgaaga ttacgacgat      720

gaagacgaga actatgatga agacagtaca gacgtaaaaa atgtcgatga tcctccaaaa      780

aatctcgatt ctatttcctc ttctaatatc gaaattgacg atgaacgacg cttggtgcta      840

aatatctcaa tatcaaaaga aacactgtca aagttaaaaa caaataatgt agaagaaatt      900

atgggaaatt ggaacaaaat ttaccacagt tttgaatacg ataaagaaac tatgataaag      960

cgattaaaac ttgaagaaag cgataaaatg atagagaaag gaaagaagaa acgaagtcga     1020

agtgatttag aagcagctac cgatgaacaa gatcgcgaaa atacaaatga tgagccagat     1080

actaatcaaa aattgcccac tcctgaaggt tcaacattca gcgatactgg gaacaagcgc     1140

cccaaacaaa gtaatttaga tttaacagtc aatctaggca tcgaaaattt atcattaaag     1200

caccttctat catctatcca gcaaaaaaaa tcccaattag gaatatcaga ttacgaatta     1260

aaacatctga ttatggatgt cagaaaaaat cggtcaaaat ggacatcgga tgaaagaatt     1320

gggcaagagg aattatacga agcctgtgaa aaggttgttt tggaacttag aaactacact     1380

gagcattcta caccatttct gaataaagtg agcaaaagag aagcccccaa ttatcatcaa     1440

atcatcaaaa agtccatgga cctgaatact gttttaaaaa aactgaaaag ctttcaatat     1500

gactccaaac aagaatttgt agacgatatt atgctaatat ggaaaaattg tttgacctat     1560

aattcagatc cttcacattt tttgagaggg catgctattg ctatgcagaa gaaatctctt     1620

cagttgattc gcatgattcc aaatatcaca atccgaaaca gggctgattt agaaaaggaa     1680

attgaagata tggaaaaaga caaagactac gaattagatg aggaagagga agttgctggt     1740

tctggaagaa aaggattgaa tatgggagct catatgttgg ccaaagagaa tggcaaggtg     1800

tcagaaaaag atagctctaa aaccgtcaag gatgaagcac caaccaatga tgacaaacta     1860

acttctgtca tccctgaggg ggaaaaagag aaagataaaa ctgcttcatc tactgtaacg     1920

gtacacgaaa atgtaaataa gaacgaaata aaagaaaatg ggaaaaatga agagcaagat     1980

atggttgagg aaagtagtaa gactgaggat tcatcaaaag atgctgatgc tgccaaaaag     2040

gatacggaag acggactaca agataaaact gcagaaaata aggaggctgg ggaaaataat     2100

gaagaggaag aggatgatga tgacgaagat gaagacgaag acatggtcga ctcccaatct     2160

tatttacttg aaaaggatga cgatagagac gatttggaaa tatccgtgtg gaaaactgta     2220

actgccaaag ttcgtgcgga aatttgctta aaaagaactg aatattttaa aaatggaaaa     2280

ttaaatagtg attcagaggc gtttttgaaa aacccacaaa gaatgaaaag gttcgaccag     2340

ctttttcttg aatataaaga gcagaaagct ttagaatcat atcgtcaaaa aatagagcaa     2400

aattccatta tgaaaaatgg ctttggaaca gtactaaaac aggaagacga tgaccaattg     2460

cagtttcata atgatcactc tttaaatgga aatgaagctt ttgaaaagca acccaatgat     2520

attgagttag atgataccag attcctacag gaatatgata ttagtaacgc cattcctgac     2580

atagtatacg agggagtaaa tactaaaaca ttagacaaga tggaagacgc ttccgtggac     2640

cgcatgcttc aaaatggtat caacaaacaa agcagatttc tggctaacaa ggatttagga     2700

ctaacaccta aaatgaacca aaatatcaca ctgattcagc aaattaggca catatgccat     2760

aaaatatccc tgatcagaat gttacagagc cctttatcgg ctcaaaactc cagaagcaat     2820

cccaacgctt tccttaacaa ccacatttat aattacacta ttattgatga ctcactcgat     2880

attgatccgg tgtcacagct tccaacgcat gattacaaaa acaacaggga gctgatatgg     2940

aaattcatgc ataagaacat atctaaggtt gctatggcca atgggtttga aactgcccat     3000

ccatcagcaa taaacatgct tactgaaatc gccggggatt acctatctaa tctgataaag     3060

actttgaagc ttcatcatga aactaactcc ttaaatagag gaacaaatgt ggaaatgctg     3120

caaacaacac tgttggaaaa cggtatcaac aggccagacg atctattttc ctatgttgaa     3180

tctgaatttg gtaaaaaaac taagaaactt caggacatca aacagaaact agaaagcttt     3240

ttgagagcct tattaaggcc aactttgcag gagttgtccg agagaaactt tgaagacgag     3300

agccaaagct tttttacagg tgactttgcc agcgaattga ctggtgaaga cttcttt        3357


<210>  21
<211>  337
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Met Asp Lys His Lys Tyr Arg Val Glu Ile Gln Gln Met Met Phe 
1               5                   10                  15      


Val Ser Gly Glu Ile Asn Asp Pro Pro Val Glu Thr Thr Ser Leu Ile 
            20                  25                  30          


Glu Asp Ile Val Arg Gly Gln Val Ile Glu Ile Leu Leu Gln Ser Asn 
        35                  40                  45              


Lys Thr Ala His Leu Arg Gly Ser Arg Ser Ile Leu Pro Glu Asp Val 
    50                  55                  60                  


Ile Phe Leu Ile Arg His Asp Lys Ala Lys Val Asn Arg Leu Arg Thr 
65                  70                  75                  80  


Tyr Leu Ser Trp Lys Asp Leu Arg Lys Asn Ala Lys Asp Gln Asp Ala 
                85                  90                  95      


Ser Ala Gly Val Ala Ser Gly Thr Gly Asn Pro Gly Ala Gly Gly Glu 
            100                 105                 110         


Asp Asp Leu Lys Lys Ala Gly Gly Gly Glu Lys Asp Glu Lys Asp Gly 
        115                 120                 125             


Gly Asn Met Met Lys Val Lys Lys Ser Gln Ile Lys Leu Pro Trp Glu 
    130                 135                 140                 


Leu Gln Phe Met Phe Asn Glu His Pro Leu Glu Asn Asn Asp Asp Asn 
145                 150                 155                 160 


Asp Asp Met Asp Glu Asp Glu Arg Glu Ala Asn Ile Val Thr Leu Lys 
                165                 170                 175     


Arg Leu Lys Met Ala Asp Asp Arg Thr Arg Asn Met Thr Lys Glu Glu 
            180                 185                 190         


Tyr Val His Trp Ser Asp Cys Arg Gln Ala Ser Phe Thr Phe Arg Lys 
        195                 200                 205             


Asn Lys Arg Phe Lys Asp Trp Ser Gly Ile Ser Gln Leu Thr Glu Gly 
    210                 215                 220                 


Lys Pro His Asp Asp Val Ile Asp Ile Leu Gly Phe Leu Thr Phe Glu 
225                 230                 235                 240 


Ile Val Cys Ser Leu Thr Glu Thr Ala Leu Lys Ile Lys Gln Arg Glu 
                245                 250                 255     


Gln Val Leu Gln Thr Gln Lys Asp Lys Ser Gln Gln Ser Ser Gln Asp 
            260                 265                 270         


Asn Thr Asn Phe Glu Phe Ala Ser Ser Thr Leu His Arg Lys Lys Arg 
        275                 280                 285             


Leu Phe Asp Gly Pro Glu Asn Val Ile Asn Pro Leu Lys Pro Arg His 
    290                 295                 300                 


Ile Glu Glu Ala Trp Arg Val Leu Gln Thr Ile Asp Met Arg His Arg 
305                 310                 315                 320 


Ala Leu Thr Asn Phe Lys Gly Gly Arg Leu Ser Ser Lys Pro Ile Ile 
                325                 330                 335     


Met 
    


<210>  22
<211>  1014
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  22
atgatggaca agcataagta tcgtgtggag attcaacaga tgatgtttgt ctctggtgaa       60

attaacgacc cacccgtaga aaccacatca ctgatagaag atatagtgag gggtcaagtg      120

atagaaattc ttttacagtc aaacaaaacg gcgcatctta ggggaagtag gagcattctc      180

cctgaagacg tcattttctt gatcagacac gacaaggcca aagtcaatcg tttgagaaca      240

tatctgtcat ggaaggattt gcgtaaaaac gccaaggacc aagatgctag tgccggtgta      300

gcgagtggca ctggaaatcc tggggcaggt ggtgaagatg atttgaaaaa agcaggtggt      360

ggcgagaaag acgaaaaaga tggtggaaac atgatgaagg tcaagaaatc ccaaattaag      420

ctgccatggg aattgcagtt tatgttcaat gaacatcctt tagaaaataa tgacgacaat      480

gatgatatgg atgaggatga acgagaagct aatatagtca ctttgaaaag gctgaaaatg      540

gctgacgata gaacacgaaa catgactaaa gaggagtacg tgcattggtc cgattgtcga      600

caggcaagtt ttacatttag gaagaataaa aggttcaagg actggtctgg aatttcgcaa      660

ttaactgagg ggaaacccca tgatgatgtg attgatatac tggggtttct aacttttgag      720

attgtctgtt ctttgacgga aacagctctg aaaatcaaac aaagagaaca ggtattacag      780

actcaaaagg acaaatccca gcaatctagc caagataata ctaactttga atttgcatca      840

tccacattac atagaaagaa aagattattt gatggacctg aaaatgttat aaacccgctc      900

aaaccaaggc atatagagga agcctggaga gtactacaaa caattgacat gaggcatagg      960

gctttgacca actttaaagg tggtagactc agttctaaac caattatcat gtaa           1014


