                         SEQUENCE LISTING

<110>  Chronos Therapeutics
 
<120>  Method of Treating Age Related Disorders

<130>  P036449WO

<150>  GB 0911888.6
<151>  2009-07-08

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Gly Glu Ser Ser Arg Phe Glu Ile His Thr Pro Val Ser Asp 
1               5                   10                  15      


Lys Lys Lys Lys Lys Cys Ser Ile His Lys Glu Arg Pro Gln Lys His 
            20                  25                  30          


Ser His Glu Ile Phe Arg Asp Ser Ser Leu Val Asn Glu Gln Ser Gln 
        35                  40                  45              


Ile Thr Arg Arg Lys Lys Arg Lys Lys Asp Phe Gln His Leu Ile Ser 
    50                  55                  60                  


Ser Pro Leu Lys Lys Ser Arg Ile Cys Asp Glu Thr Ala Asn Ala Thr 
65                  70                  75                  80  


Ser Thr Leu Lys Lys Arg Lys Lys Arg Arg Tyr Ser Ala Leu Glu Val 
                85                  90                  95      


Asp Glu Glu Ala Gly Val Thr Val Val Leu Val Asp Lys Glu Asn Ile 
            100                 105                 110         


Asn Asn Thr Pro Lys His Phe Arg Lys Asp Val Asp Val Val Cys Val 
        115                 120                 125             


Asp Met Ser Ile Glu Gln Lys Leu Pro Arg Lys Pro Lys Thr Asp Lys 
    130                 135                 140                 


Phe Gln Val Leu Ala Lys Ser His Ala His Lys Ser Glu Ala Leu His 
145                 150                 155                 160 


Ser Lys Val Arg Glu Lys Lys Asn Lys Lys His Gln Arg Lys Ala Ala 
                165                 170                 175     


Ser Trp Glu Ser Gln Arg Ala Arg Asp Thr Leu Pro Gln Ser Glu Ser 
            180                 185                 190         


His Gln Glu Glu Ser Trp Leu Ser Val Gly Pro Gly Gly Glu Ile Thr 
        195                 200                 205             


Glu Leu Pro Ala Ser Ala His Lys Asn Lys Ser Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Ser Ser Asn Arg Glu Tyr Glu Thr Leu Ala Met Pro Glu Gly Ser 
225                 230                 235                 240 


Gln Ala Gly Arg Glu Ala Gly Thr Asp Met Gln Glu Ser Gln Pro Thr 
                245                 250                 255     


Val Gly Leu Asp Asp Glu Thr Pro Gln Leu Leu Gly Pro Thr His Lys 
            260                 265                 270         


Lys Lys Ser Lys Lys Lys Lys Lys Lys Lys Ser Asn His Gln Glu Phe 
        275                 280                 285             


Glu Ala Leu Ala Met Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly 
    290                 295                 300                 


Ala Asp Met Gln Glu Ser Arg Pro Ala Val Gly Leu His Gly Glu Thr 
305                 310                 315                 320 


Ala Gly Ile Pro Ala Pro Ala Tyr Lys Asn Lys Ser Lys Lys Lys Lys 
                325                 330                 335     


Lys Lys Ser Asn His Gln Glu Phe Glu Ala Val Ala Met Pro Glu Ser 
            340                 345                 350         


Leu Glu Ser Ala Tyr Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly 
        355                 360                 365             


Thr Val Glu Gly Ser Thr Ala Leu Lys Gly Phe Lys Glu Ser Asn Ser 
    370                 375                 380                 


Thr Lys Lys Lys Ser Lys Lys Arg Lys Leu Thr Ser Val Lys Arg Ala 
385                 390                 395                 400 


Arg Val Ser Gly Asp Asp Phe Ser Val Pro Ser Lys Asn Ser Glu Ser 
                405                 410                 415     


Thr Leu Phe Asp Ser Val Glu Gly Asp Gly Ala Met Met Glu Glu Gly 
            420                 425                 430         


Val Lys Ser Arg Pro Arg Gln Lys Lys Thr Gln Ala Cys Leu Ala Ser 
        435                 440                 445             


Lys His Val Gln Glu Ala Pro Arg Leu Glu Pro Ala Asn Glu Glu His 
    450                 455                 460                 


Asn Val Glu Thr Ala Glu Asp Ser Glu Ile Arg Tyr Leu Ser Ala Asp 
465                 470                 475                 480 


Ser Gly Asp Ala Asp Asp Ser Asp Ala Asp Leu Gly Ser Ala Val Lys 
                485                 490                 495     


Gln Leu Gln Glu Phe Ile Pro Asn Ile Lys Asp Arg Ala Thr Ser Thr 
            500                 505                 510         


Ile Lys Arg Met Tyr Arg Asp Asp Leu Glu Arg Phe Lys Glu Phe Lys 
        515                 520                 525             


Ala Gln Gly Val Ala Ile Lys Phe Gly Lys Phe Ser Val Lys Glu Asn 
    530                 535                 540                 


Lys Gln Leu Glu Lys Asn Val Glu Asp Phe Leu Ala Leu Thr Gly Ile 
545                 550                 555                 560 


Glu Ser Ala Asp Lys Leu Leu Tyr Thr Asp Arg Tyr Pro Glu Glu Lys 
                565                 570                 575     


Ser Val Ile Thr Asn Leu Lys Arg Arg Tyr Ser Phe Arg Leu His Ile 
            580                 585                 590         


Gly Arg Asn Ile Ala Arg Pro Trp Lys Leu Ile Tyr Tyr Arg Ala Lys 
        595                 600                 605             


Lys Met Phe Asp Val Asn Asn Tyr Lys Gly Arg Tyr Ser Glu Gly Asp 
    610                 615                 620                 


Thr Glu Lys Leu Lys Met Tyr His Ser Leu Leu Gly Asn Asp Trp Lys 
625                 630                 635                 640 


Thr Ile Gly Glu Met Val Ala Arg Ser Ser Leu Ser Val Ala Leu Lys 
                645                 650                 655     


Phe Ser Gln Ile Ser Ser Gln Arg Asn Arg Gly Ala Trp Ser Lys Ser 
            660                 665                 670         


Glu Thr Arg Lys Leu Ile Lys Ala Val Glu Glu Val Ile Leu Lys Lys 
        675                 680                 685             


Met Ser Pro Gln Glu Leu Lys Glu Val Asp Ser Lys Leu Gln Glu Asn 
    690                 695                 700                 


Pro Glu Ser Cys Leu Ser Ile Val Arg Glu Lys Leu Tyr Lys Gly Ile 
705                 710                 715                 720 


Ser Trp Val Glu Val Glu Ala Lys Val Gln Thr Arg Asn Trp Met Gln 
                725                 730                 735     


Cys Lys Ser Lys Trp Thr Glu Ile Leu Thr Lys Arg Met Thr Asn Gly 
            740                 745                 750         


Arg Arg Ile Tyr Tyr Gly Met Asn Ala Leu Arg Ala Lys Val Ser Leu 
        755                 760                 765             


Ile Glu Arg Leu Tyr Glu Ile Asn Val Glu Asp Thr Asn Glu Ile Asp 
    770                 775                 780                 


Trp Glu Asp Leu Ala Ser Ala Ile Gly Asp Val Pro Pro Ser Tyr Val 
785                 790                 795                 800 


Gln Thr Lys Phe Ser Arg Leu Lys Ala Val Tyr Val Pro Phe Trp Gln 
                805                 810                 815     


Lys Lys Thr Phe Pro Glu Ile Ile Asp Tyr Leu Tyr Glu Thr Thr Leu 
            820                 825                 830         


Pro Leu Leu Lys Glu Lys Leu Glu Lys Met Met Glu Lys Lys Gly Thr 
        835                 840                 845             


Lys Ile Gln Thr Pro Ala Ala Pro Lys Gln Val Phe Pro Phe Arg Asp 
    850                 855                 860                 


Ile Phe Tyr Tyr Glu Asp Asp Ser Glu Gly Glu Asp Ile Glu Lys Glu 
865                 870                 875                 880 


Ser Glu Gly Gln Ala Pro Cys Met Ala His Ala Cys Asn Ser Ser Thr 
                885                 890                 895     


Leu Gly Gly Gln Gly Arg Trp Ile Ile 
            900                 905 


<210>  2
<211>  3137
<212>  DNA
<213>  Homo sapiens

<400>  2
agcagcactt ccgggttggg agaaaggtgg cggcgctttc ggagggaata aaatggaagg       60

agaatcaagc agatttgaaa tccacactcc agtttctgac aagaaaaaga aaaagtgttc      120

tatacataag gaaagacctc agaaacattc ccacgaaatt ttcagagact cctccctggt      180

gaatgaacag tctcaaataa ctaggaggaa aaagaggaaa aaagatttcc agcatctcat      240

ttcttctcct ttgaaaaaat ccagaatctg tgatgagact gcaaatgcca cttccacact      300

caaaaagaga aaaaagagaa gatatagtgc tttggaggtg gacgaggaag caggtgttac      360

agttgtcctt gtggataaag aaaatattaa caacacacca aagcatttta gaaaggatgt      420

tgatgttgtt tgtgttgata tgagcataga acagaagtta ccaagaaagc ctaaaacaga      480

caaatttcag gtacttgcta agtcacatgc acataaatca gaagccctgc acagtaaagt      540

tagggagaaa aagaataaaa agcatcagag gaaagctgca tcctgggaga gccagcgggc      600

aagggacacc ctgcctcagt cagaatccca ccaggaggag tcctggcttt ctgtgggtcc      660

agggggtgaa attacagaac taccagcatc tgctcataaa aacaagtcta agaaaaaaaa      720

gaaaaagtcc agtaaccggg aatatgagac actggccatg cctgaaggat cgcaagcagg      780

cagagaggcc gggactgata tgcaggaatc ccagcctact gtgggcttgg atgatgaaac      840

tccacaacta ctaggaccta ctcacaaaaa aaagtctaag aaaaaaaaga agaaaaagtc      900

caatcaccag gaatttgagg cattggccat gcctgaagga tcacaagtgg gcagtgaggt      960

tggggctgat atgcaggaat cccggcctgc tgtgggcctg catggtgaaa ctgcaggaat     1020

accagcacct gcttataaaa acaagtctaa gaaaaaaaag aaaaagtcca atcaccagga     1080

atttgaggca gtggccatgc ctgagagcct cgagagtgca taccctgaag gatcacaggt     1140

gggcagtgag gttgggactg tggaaggcag tacagctctt aaagggttca aggaatccaa     1200

cagtacaaag aagaagtcta agaaaaggaa gcttacgtct gtcaaaaggg cacgagtgtc     1260

tggtgatgat ttttcagtgc ccagtaagaa ctctgagagc acactctttg attcagtaga     1320

aggtgatggc gccatgatgg aagaaggtgt gaaatctagg ccccgacaaa agaaaaccca     1380

ggcctgtttg gcaagcaagc acgtgcaaga ggcgccaagg ttagaacctg caaatgaaga     1440

acacaatgtg gaaacagctg aagattccga aataagatac ttatctgcag attcaggaga     1500

tgccgatgat tcagatgcgg atttgggttc tgccgtgaaa cagcttcagg agttcattcc     1560

taacatcaag gacagggcca ccagcacaat caagcggatg taccgggacg acttggaacg     1620

gtttaaggaa tttaaagcac aaggtgtcgc tattaaattt ggcaagtttt ctgtaaagga     1680

aaataagcag ttagagaaaa atgtggaaga ctttctagcc ctgacaggca ttgagagtgc     1740

agacaagctg ctgtacacgg acagatatcc tgaggaaaaa tctgtgatca ccaacttaaa     1800

aaggagatac tcgtttagat tacacattgg taggaacatt gcccggccct ggaaacttat     1860

atactatcga gcaaagaaga tgttcgatgt caacaattac aaaggcaggt atagcgaagg     1920

agatactgag aagttaaaga tgtaccattc tctccttggg aatgactgga agacgattgg     1980

tgagatggtg gcccgaagta gcctctccgt ggccctcaag ttctcacaga tcagcagtca     2040

aagaaatcgt ggtgcttgga gtaagtctga aacccggaaa ctaatcaagg ctgtcgaaga     2100

agtgattctg aagaagatgt ctccccagga gttaaaagag gtggattcca aactccaaga     2160

aaatcctgaa agttgcctat caattgttcg ggaaaaactc tacaagggca tatcttgggt     2220

agaagtagaa gctaaagtgc aaaccagaaa ttggatgcag tgtaaaagta agtggacaga     2280

aattctaacc aagaggatga ctaatggtcg gcgtatctac tatggcatga atgccctgcg     2340

ggccaaggtc agccttattg aaaggttgta tgaaataaat gtggaagata ctaatgaaat     2400

agactgggaa gatcttgcta gtgccatagg tgatgttcct ccatcttacg ttcaaactaa     2460

attttctagg ctgaaagctg tctatgttcc attttggcag aaaaagactt ttccagagat     2520

catcgactac ctttatgaga cgactctacc tttgctgaag gaaaagttag aaaaaatgat     2580

ggagaaaaaa ggcactaaaa tccagactcc tgcagcaccc aagcaagttt tcccatttcg     2640

agacatcttt tattatgaag acgatagtga aggagaggac atagaaaaag aaagcgaagg     2700

ccaggcgcca tgcatggctc acgcctgtaa ttccagtact ttgggaggcc aaggccggtg     2760

gatcatctga ggtcaggagt tcgagaccgg cctgaccaac atggtgaaga cctgtcacta     2820

ttaaaaatgc gaaaattagc cgggtgtggt agtgcacacc tgtaatttca actacttggg     2880

aggctgaggc aggagaattg cttgaaccca ggaggtggag gttgcagtga gccaagatcg     2940

caccaccgca tgagagagag agattactat ttcttgtccc tttttctcag tttgattata     3000

tttatataca tatgtcagta aatctgtttt cagtattgat gtttaataaa gaatgtacaa     3060

tggccagagt tctactcttt cctctggagc attaaaatat attgccattc ctattaaaac     3120

gtatttgaat gtgaaaa                                                    3137


<210>  3
<211>  570
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Asp Ser Val Ser Asn Leu Lys Ser Thr Asn Phe Gln Asn Asn Asn 
1               5                   10                  15      


Asp Pro Lys Glu Ser Val Glu Glu Ala Val Leu Arg Tyr Val Gly Val 
            20                  25                  30          


Asp Leu Lys Asn His Ile Lys Lys Thr Lys Lys Lys Leu Lys Lys Gln 
        35                  40                  45              


Lys Lys Arg Lys His Gly Ser Lys Met Ser His Glu Asp Glu Asp Thr 
    50                  55                  60                  


Asp Met Asp Trp Tyr Leu Lys Thr Ser Gly Ser Lys Asp Leu Arg Lys 
65                  70                  75                  80  


Val Asp Asp Ile Glu Pro Asn Ser Val Ala Val Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Tyr Asn Ser Ser Met Arg Glu Lys Asp Lys Arg Ser Cys His Lys 
            100                 105                 110         


Lys Ser Ser Asn Ser Arg Ser Glu Arg Lys Lys His Arg Lys Arg Lys 
        115                 120                 125             


Ser Ser Lys Glu Arg Lys Ala Lys Ile Lys Met Val Leu Asp Pro Gln 
    130                 135                 140                 


Leu Thr Thr Leu Asp Asp Gly Ile Thr Thr Thr Ala Phe Leu Pro Asp 
145                 150                 155                 160 


Asp Leu Ile Ala Glu Thr Ala Phe Asp Lys Tyr Val Asp Thr Glu Lys 
                165                 170                 175     


Ala Tyr Leu Ala Lys His Pro Ser Lys Ser Leu Glu Val Asn Glu Asp 
            180                 185                 190         


Asp Lys Glu Asn Asn Phe Asn Asn Asn Ser Ser Thr Leu Val Arg Ile 
        195                 200                 205             


Tyr Thr Asp Leu Glu Gly Ile Pro Asn Asp Gly Ser Tyr Ile Lys Arg 
    210                 215                 220                 


Thr Pro Lys Ile Pro Glu Lys Asp Val Lys Ser Asp Asp Leu Ile Leu 
225                 230                 235                 240 


Ala Pro Glu Glu Asn Asn Gly Asp Thr Ala Leu Leu Arg Ser Asp Ile 
                245                 250                 255     


Val Lys Ala Ser Val Ile Asp Gly Ala Ile Thr Lys Ser Ile Gly Lys 
            260                 265                 270         


Lys Phe Thr Pro Ser Glu Glu Asn Ala Leu Asp Gln Phe Ile Glu Glu 
        275                 280                 285             


Tyr Met Lys Ile Arg Gly Leu Asp Arg Arg Gln Met Cys Glu Arg Ile 
    290                 295                 300                 


Trp Ser Thr Asp Gly Val Ile Arg Asp Gly Phe Trp Ala Asn Ile Ser 
305                 310                 315                 320 


Lys Val Leu Pro Tyr Arg Thr Arg Ser Ser Ile Tyr Lys His Ile Arg 
                325                 330                 335     


Arg Lys Tyr His Ile Phe Glu Gln Arg Gly Lys Trp Thr Pro Glu Glu 
            340                 345                 350         


Asp Gln Glu Leu Ala Arg Leu Cys Leu Glu Lys Glu Gly His Trp Thr 
        355                 360                 365             


Glu Val Gly Lys Leu Leu Gly Arg Met Pro Glu Asp Cys Arg Asp Arg 
    370                 375                 380                 


Trp Arg Asn Tyr Met Lys Cys Gly Ser Lys Arg Gly Ser Lys Arg Trp 
385                 390                 395                 400 


Ser Lys Glu Glu Glu Glu Leu Leu Thr Thr Val Val Asn Glu Met Ile 
                405                 410                 415     


Glu Glu Ala His Gln Tyr Gln Arg Met Lys Ala Leu Glu Ala Ala Asn 
            420                 425                 430         


Lys Asn Asp Arg Tyr Asn Gln Met Tyr Ser Arg Gly Pro Lys Gly Lys 
        435                 440                 445             


Arg Ile Ser Asp Asn Pro Thr Phe Lys Asp Met Ile Asn Trp Thr Val 
    450                 455                 460                 


Val Ser Glu Arg Met Ser Gly Thr Arg Ser Arg Ile Gln Cys Arg Tyr 
465                 470                 475                 480 


Lys Trp Asn Lys Leu Val Thr Asp Glu Ala Ala Arg Ser Met Leu Ser 
                485                 490                 495     


Ile Pro Val Ser Glu Arg Lys Trp Leu Leu Glu Arg Leu Lys Gln Leu 
            500                 505                 510         


Pro Lys Thr Ser Tyr Ser Asn Ile Asp Trp Asn Ser Ile Ala Thr Tyr 
        515                 520                 525             


Lys Pro Gly Tyr Pro Arg Thr Gly Leu Glu Leu Arg Leu Cys Tyr Glu 
    530                 535                 540                 


Gln Met Arg Glu Lys Ile His Asp Phe Lys Gly Arg Ser Thr Ala Glu 
545                 550                 555                 560 


Ile Ile Asp Ser Leu Leu Glu Gln Ile Asn 
                565                 570 


<210>  4
<211>  1713
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  4
atggacagcg tgtcaaacct taagagcaca aattttcaga acaataatga cccaaaagaa       60

tctgtagaag aagcagtgct aaggtatgtg ggagtcgact tgaagaatca tattaaaaag      120

acaaagaaga aattgaagaa acagaagaag agaaagcatg gttcaaaaat gtctcatgaa      180

gatgaagaca ctgatatgga ttggtatttg aaaacatcgg gttcaaaaga tttacgtaaa      240

gtggatgata tcgaaccaaa ttctgttgct gtagcagctg ttgctgccgc atacaacagc      300

tcaatgagag aaaaagataa gaggagctgt cataaaaaat cttctaatag tagatcagag      360

aggaagaagc accgtaaaag aaaaagctct aaagaaagaa aagccaaaat aaaaatggtc      420

ctagatccgc agctgactac actggacgat ggcataacga caacagcatt tttacctgat      480

gatctcattg ctgaaacagc ttttgataag tatgttgata ctgaaaaggc atacctagct      540

aaacatccaa gtaaatcgtt agaagttaat gaggatgata aagaaaacaa ctttaataac      600

aatagcagca cgctggttag aatttatacc gatttagagg ggataccaaa tgacggcagc      660

tacataaagc gcactccaaa gataccagaa aaggatgtga aatcagacga cttgatattg      720

gcaccagaag aaaacaatgg agataccgca ttactgcgat ccgatattgt gaaagcgtca      780

gtaattgacg gtgctatcac aaaatccatc ggtaagaagt tcactcccag cgaggaaaat      840

gctttggacc aattcatcga agaatacatg aaaataagag gcttggatag acgccaaatg      900

tgcgagagaa tttggtctac agacggagtc attagagatg ggttttgggc aaatatcagc      960

aaagttttac cttatagaac aaggtcctca atatataaac atataagaag aaaatatcat     1020

attttcgaac agcgtgggaa gtggacgcca gaggaagatc aagaattggc aagattatgt     1080

ttagaaaaag agggtcattg gaccgaagta ggcaaattgt taggcagaat gcctgaagat     1140

tgtagggacc gttggagaaa ctatatgaag tgtggttcaa agcgaggttc taaaagatgg     1200

tcgaaagaag aagaagaatt gttgactact gtagtaaatg aaatgattga agaggcacac     1260

caatatcaaa ggatgaaggc attggaggct gccaacaaaa atgatagata caatcaaatg     1320

tattctaggg gtccaaaggg aaagagaatt agcgataatc ctaccttcaa agatatgatc     1380

aattggactg tcgtcagtga acgcatgagc ggaactagat cccgtataca gtgccgctat     1440

aagtggaata aattagtaac agatgaagca gccagaagta tgttgagcat tcctgtttct     1500

gaaaggaagt ggctgctaga acgattgaaa cagctaccta aaacgtccta ttcaaatatc     1560

gactggaaca gtatagctac ctacaagccc ggatatcctc gaactggtct tgaactgaga     1620

ttatgttacg agcagatgag agaaaagatt catgacttta aaggaaggtc aacagctgaa     1680

ataattgatt cattgttgga acaaatcaat taa                                  1713


<210>  5
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Gly Glu Ser Ser Arg Phe Glu Ile His Thr Pro Val Ser Asp 
1               5                   10                  15      


Lys Lys Lys Lys Lys Cys Ser Ile His Lys Glu Arg Pro Gln Lys His 
            20                  25                  30          


Ser His Glu Ile Phe Arg Asp Ser Ser Leu Val Asn Glu Gln Ser Gln 
        35                  40                  45              


Ile Thr Arg Arg Lys Lys Arg Lys Lys Asp Phe Gln His Leu Ile Ser 
    50                  55                  60                  


Ser Pro Leu Lys Lys Ser Arg Ile Cys Asp Glu Thr Ala Asn Ala Thr 
65                  70                  75                  80  


Ser Thr Leu Lys Lys Arg Lys Lys Arg Arg Tyr Ser Ala Leu Glu Val 
                85                  90                  95      


Asp Glu Glu Ala Gly Val Thr Val Val Leu Val Asp Lys Glu Asn Ile 
            100                 105                 110         


Asn Asn Thr Pro Lys His Phe Arg Lys Asp Val Asp Val Val Cys Val 
        115                 120                 125             


Asp Met Ser Ile Glu Gln Lys Leu Pro Arg Lys Pro Lys Thr Asp Lys 
    130                 135                 140                 


Phe Gln Val Leu Ala Lys Ser His Ala His Lys Ser Glu Ala Leu His 
145                 150                 155                 160 


Ser Lys Val Arg Glu Lys Lys Asn Lys Lys His Gln Arg Lys Ala Ala 
                165                 170                 175     


Ser Trp Glu Ser Gln Arg Ala Arg Asp Thr Leu Pro Gln Ser Glu Ser 
            180                 185                 190         


His Gln Glu Glu Ser Trp Leu Ser Val Gly Pro Gly Gly Glu Ile Thr 
        195                 200                 205             


Glu Leu Pro Ala Ser Ala His Lys Asn Lys Ser Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Ser Ser Asn Arg Glu Tyr Glu Thr Leu Ala Met Pro Glu Gly Ser 
225                 230                 235                 240 


Gln Ala Gly Arg Glu Ala Gly Thr Asp Met Gln Glu Ser Gln Pro Thr 
                245                 250                 255     


Val Gly Leu Asp Asp Glu Thr Pro Gln Leu Leu Gly Pro Thr His Lys 
            260                 265                 270         


Lys Lys Ser Lys Lys Lys Lys Lys Lys Lys Ser Asn His Gln Glu Phe 
        275                 280                 285             


Glu Ala Leu Ala Met Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly 
    290                 295                 300                 


Ala Asp Met Gln Glu Ser Arg Pro Ala Val Gly Leu His Gly Glu Thr 
305                 310                 315                 320 


Ala Gly Ile Pro Ala Pro Ala Tyr Lys Asn Lys Ser Lys Lys Lys Lys 
                325                 330                 335     


Lys Lys Ser Asn His Gln Glu Phe Glu Ala Val Ala Met Pro Glu Ser 
            340                 345                 350         


Leu Glu Ser Ala Tyr Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly 
        355                 360                 365             


Thr Val Glu Gly Ser Thr Ala Leu Lys Gly Phe Lys Glu Ser Asn Ser 
    370                 375                 380                 


Thr Lys Lys Lys Ser Lys Lys Arg Lys Leu Thr Ser Val Lys Arg Ala 
385                 390                 395                 400 


Arg Val Ser Gly Asp Asp Phe Ser Val Pro Ser Lys Asn Ser Glu Ser 
                405                 410                 415     


Thr Leu Phe Asp Ser Val Glu Gly Asp Gly Ala Met Met Glu Glu Gly 
            420                 425                 430         


Val Lys Ser Arg Pro Arg Gln Lys Lys Thr Gln Ala Cys Leu Ala Ser 
        435                 440                 445             


Lys His Val Gln Glu Ala Pro Arg Leu Glu Pro Ala Asn Glu Glu His 
    450                 455                 460                 


Asn Val Glu Thr Ala Glu Asp Ser Glu Ile Arg Tyr Leu Ser Ala Asp 
465                 470                 475                 480 


Ser Gly Asp Ala Asp Asp Ser Asp Ala Asp Leu Gly Ser Ala Val Lys 
                485                 490                 495     


Gln Leu Gln Glu Phe Ile Pro Asn Ile Lys Asp Arg Ala Thr Ser Thr 
            500                 505                 510         


Ile Lys Arg Met Tyr Arg Asp Asp Leu Glu Arg Phe Lys Glu Phe Lys 
        515                 520                 525             


Ala Gln Gly Val Ala Ile Lys Phe Gly Lys Phe Ser Val Lys Glu Asn 
    530                 535                 540                 


Lys Gln Leu Glu Lys Asn Val Glu Asp Phe Leu Ala Leu Thr Gly Ile 
545                 550                 555                 560 


Glu Ser Ala Asp Lys Leu Leu Tyr Thr Asp Arg Tyr Pro Glu Glu Lys 
                565                 570                 575     


Ser Val Ile Thr Asn Leu Lys Arg Arg Tyr Ser Phe Arg Leu His Ile 
            580                 585                 590         


Gly Arg Asn Ile Ala Arg Pro Trp Lys Leu Ile Tyr Tyr Arg Ala Lys 
        595                 600                 605             


Lys Met Phe Asp Val Asn Asn Tyr Lys Gly Arg Tyr Ser Glu Gly Asp 
    610                 615                 620                 


Thr Glu Lys Leu Lys Met Tyr His Ser Leu Leu Gly Asn Asp Trp Lys 
625                 630                 635                 640 


Thr Ile Gly Glu Met Val Ala Arg Ser Ser Leu Ser Val Ala Leu Lys 
                645                 650                 655     


Phe Ser Gln Ile Ser Ser Gln Arg Asn Arg Gly Ala Trp Ser Lys Ser 
            660                 665                 670         


Glu Thr Arg Lys Leu Ile Lys Ala Val Glu Glu Val Ile Leu Lys Lys 
        675                 680                 685             


Met Ser Pro Gln Glu Leu Lys Glu Val Asp Ser Lys Leu Gln Glu Asn 
    690                 695                 700                 


Pro Glu Ser Cys Leu Ser Ile Val Arg Glu Lys Leu Tyr Lys Gly Ile 
705                 710                 715                 720 


Ser Trp Val Glu Val Glu Ala Lys Val Gln Thr Arg Asn Trp Met Gln 
                725                 730                 735     


Cys Lys Ser Lys Trp Thr Glu Ile Leu Thr Lys Arg Met Thr Asn Gly 
            740                 745                 750         


Arg Arg Ile Tyr Tyr Gly Met Asn Ala Leu Arg Ala Lys Val Ser Leu 
        755                 760                 765             


Ile Glu Arg Leu Tyr Glu Ile Asn Val Glu Asp Thr Asn Glu Ile Asp 
    770                 775                 780                 


Trp Glu Asp Leu Ala Ser Ala Ile Gly Asp Val Pro Pro Ser Tyr Val 
785                 790                 795                 800 


Gln Thr Lys Phe Ser Arg Leu Lys Ala Val Tyr Val Pro Phe Trp Gln 
                805                 810                 815     


Lys Lys Thr Phe Pro Glu Ile Ile Asp Tyr Leu Tyr Glu Thr Thr Leu 
            820                 825                 830         


Pro Leu Leu Lys Glu Lys Leu Glu Lys Met Met Glu Lys Lys Gly Thr 
        835                 840                 845             


Lys Ile Gln Thr Pro Ala Ala Pro Lys Gln Val Phe Pro Phe Arg Asp 
    850                 855                 860                 


Ile Phe Tyr Tyr Glu Asp Asp Ser Glu Gly His Arg Lys Arg Lys Arg 
865                 870                 875                 880 


Arg 
    


<210>  6
<211>  2718
<212>  DNA
<213>  Homo sapiens

<400>  6
atggaaggag aatcaagcag atttgaaatc cacactccag tttctgacaa gaaaaagaaa       60

aagtgttcta tacataagga aagacctcag aaacattccc acgaaatttt cagagactcc      120

tccctggtga atgaacagtc tcaaataact aggaggaaaa agaggaaaaa agatttccag      180

catctcattt cttctccttt gaaaaaatcc agaatctgtg atgagactgc aaatgccact      240

tccacactca aaaagagaaa aaagagaaga tatagtgctt tggaggtgga cgaggaagca      300

ggtgttacag ttgtccttgt ggataaagaa aatattaaca acacaccaaa gcattttaga      360

aaggatgttg atgttgtttg tgttgatatg agcatagaac agaagttacc aagaaagcct      420

aaaacagaca aatttcaggt acttgctaag tcacatgcac ataaatcaga agccctgcac      480

agtaaagtta gggagaaaaa gaataaaaag catcagagga aagctgcatc ctgggagagc      540

cagcgggcaa gggacaccct gcctcagtca gaatcccacc aggaggagtc ctggctttct      600

gtgggtccag ggggtgaaat tacagaacta ccagcatctg ctcataaaaa caagtctaag      660

aaaaaaaaga aaaagtccag taaccgggaa tatgagacac tggccatgcc tgaaggatcg      720

caagcaggca gagaggccgg gactgatatg caggaatccc agcctactgt gggcttggat      780

gatgaaactc cacaactact aggacctact cacaaaaaaa agtctaagaa aaaaaagaag      840

aaaaagtcca atcaccagga atttgaggca ttggccatgc ctgaaggatc acaagtgggc      900

agtgaggttg gggctgatat gcaggaatcc cggcctgctg tgggcctgca tggtgaaact      960

gcaggaatac cagcacctgc ttataaaaac aagtctaaga aaaaaaagaa aaagtccaat     1020

caccaggaat ttgaggcagt ggccatgcct gagagcctcg agagtgcata ccctgaagga     1080

tcacaggtgg gcagtgaggt tgggactgtg gaaggcagta cagctcttaa agggttcaag     1140

gaatccaaca gtacaaagaa gaagtctaag aaaaggaagc ttacgtctgt caaaagggca     1200

cgagtgtctg gtgatgattt ttcagtgccc agtaagaact ctgagagcac actctttgat     1260

tcagtagaag gtgatggcgc catgatggaa gaaggtgtga aatctaggcc ccgacaaaag     1320

aaaacccagg cctgtttggc aagcaagcac gtgcaagagg cgccaaggtt agaacctgca     1380

aatgaagaac acaatgtgga aacagctgaa gattccgaaa taagatactt atctgcagat     1440

tcaggagatg ccgatgattc agatgcggat ttgggttctg ccgtgaaaca gcttcaggag     1500

ttcattccta acatcaagga cagggccacc agcacaatca agcggatgta ccgggacgac     1560

ttggaacggt ttaaggaatt taaagcacaa ggtgtcgcta ttaaatttgg caagttttct     1620

gtaaaggaaa ataagcagtt agagaaaaat gtggaagact ttctagccct gacaggcatt     1680

gagagtgcag acaagctgct gtacacggac agatatcctg aggaaaaatc tgtgatcacc     1740

aacttaaaaa ggagatactc gtttagatta cacattggta ggaacattgc ccggccctgg     1800

aaacttatat actatcgagc aaagaagatg ttcgatgtca acaattacaa aggcaggtat     1860

agcgaaggag atactgagaa gttaaagatg taccattctc tccttgggaa tgactggaag     1920

acgattggtg agatggtggc ccgaagtagc ctctccgtgg ccctcaagtt ctcacagatc     1980

agcagtcaaa gaaatcgtgg tgcttggagt aagtctgaaa cccggaaact aatcaaggct     2040

gtcgaagaag tgattctgaa gaagatgtct ccccaggagt taaaagaggt ggattccaaa     2100

ctccaagaaa atcctgaaag ttgcctatca attgttcggg aaaaactcta caagggcata     2160

tcttgggtag aagtagaagc taaagtgcaa accagaaatt ggatgcagtg taaaagtaag     2220

tggacagaaa ttctaaccaa gaggatgact aatggtcggc gtatctacta tggcatgaat     2280

gccctgcggg ccaaggtcag ccttattgaa aggttgtatg aaataaatgt ggaagatact     2340

aatgaaatag actgggaaga tcttgctagt gccataggtg atgttcctcc atcttacgtt     2400

caaactaaat tttctaggct gaaagctgtc tatgttccat tttggcagaa aaagactttt     2460

ccagagatca tcgactacct ttatgagacg actctacctt tgctgaagga aaagttagaa     2520

aaaatgatgg agaaaaaagg cactaaaatc cagactcctg cagcacccaa gcaagttttc     2580

ccatttcgag acatctttta ttatgaagac gatagtgaag gagaggacat agaaaaagaa     2640

agcgaaggcc aggcgccatg catggctcac gcctgtaatt ccagtacttt gggaggccaa     2700

ggccggtgga tcatctga                                                   2718


<210>  7
<211>  2643
<212>  DNA
<213>  Homo sapiens

<400>  7
atggaaggag aatcaagcag atttgaaatc cacactccag tttctgacaa gaaaaagaaa       60

aagtgttcta tacataagga aagacctcag aaacattccc acgaaatttt cagagactcc      120

tccctggtga atgaacagtc tcaaataact aggaggaaaa agaggaaaaa agatttccag      180

catctcattt cttctccttt gaaaaaatcc agaatctgtg atgagactgc aaatgccact      240

tccacactca aaaagagaaa aaagagaaga tatagtgctt tggaggtgga cgaggaagca      300

ggtgttacag ttgtccttgt ggataaagaa aatattaaca acacaccaaa gcattttaga      360

aaggatgttg atgttgtttg tgttgatatg agcatagaac agaagttacc aagaaagcct      420

aaaacagaca aatttcaggt acttgctaag tcacatgcac ataaatcaga agccctgcac      480

agtaaagtta gggagaaaaa gaataaaaag catcagagga aagctgcatc ctgggagagc      540

cagcgggcaa gggacaccct gcctcagtca gaatcccacc aggaggagtc ctggctttct      600

gtgggtccag ggggtgaaat tacagaacta ccagcatctg ctcataaaaa caagtctaag      660

aaaaaaaaga aaaagtccag taaccgggaa tatgagacac tggccatgcc tgaaggatcg      720

caagcaggca gagaggccgg gactgatatg caggaatccc agcctactgt gggcttggat      780

gatgaaactc cacaactact aggacctact cacaaaaaaa agtctaagaa aaaaaagaag      840

aaaaagtcca atcaccagga atttgaggca ttggccatgc ctgaaggatc acaagtgggc      900

agtgaggttg gggctgatat gcaggaatcc cggcctgctg tgggcctgca tggtgaaact      960

gcaggaatac cagcacctgc ttataaaaac aagtctaaga aaaaaaagaa aaagtccaat     1020

caccaggaat ttgaggcagt ggccatgcct gagagcctcg agagtgcata ccctgaagga     1080

tcacaggtgg gcagtgaggt tgggactgtg gaaggcagta cagctcttaa agggttcaag     1140

gaatccaaca gtacaaagaa gaagtctaag aaaaggaagc ttacgtctgt caaaagggca     1200

cgagtgtctg gtgatgattt ttcagtgccc agtaagaact ctgagagcac actctttgat     1260

tcagtagaag gtgatggcgc catgatggaa gaaggtgtga aatctaggcc ccgacaaaag     1320

aaaacccagg cctgtttggc aagcaagcac gtgcaagagg cgccaaggtt agaacctgca     1380

aatgaagaac acaatgtgga aacagctgaa gattccgaaa taagatactt atctgcagat     1440

tcaggagatg ccgatgattc agatgcggat ttgggttctg ccgtgaaaca gcttcaggag     1500

ttcattccta acatcaagga cagggccacc agcacaatca agcggatgta ccgggacgac     1560

ttggaacggt ttaaggaatt taaagcacaa ggtgtcgcta ttaaatttgg caagttttct     1620

gtaaaggaaa ataagcagtt agagaaaaat gtggaagact ttctagccct gacaggcatt     1680

gagagtgcag acaagctgct gtacacggac agatatcctg aggaaaaatc tgtgatcacc     1740

aacttaaaaa ggagatactc gtttagatta cacattggta ggaacattgc ccggccctgg     1800

aaacttatat actatcgagc aaagaagatg ttcgatgtca acaattacaa aggcaggtat     1860

agcgaaggag atactgagaa gttaaagatg taccattctc tccttgggaa tgactggaag     1920

acgattggtg agatggtggc ccgaagtagc ctctccgtgg ccctcaagtt ctcacagatc     1980

agcagtcaaa gaaatcgtgg tgcttggagt aagtctgaaa cccggaaact aatcaaggct     2040

gtcgaagaag tgattctgaa gaagatgtct ccccaggagt taaaagaggt ggattccaaa     2100

ctccaagaaa atcctgaaag ttgcctatca attgttcggg aaaaactcta caagggcata     2160

tcttgggtag aagtagaagc taaagtgcaa accagaaatt ggatgcagtg taaaagtaag     2220

tggacagaaa ttctaaccaa gaggatgact aatggtcggc gtatctacta tggcatgaat     2280

gccctgcggg ccaaggtcag ccttattgaa aggttgtatg aaataaatgt ggaagatact     2340

aatgaaatag actgggaaga tcttgctagt gccataggtg atgttcctcc atcttacgtt     2400

caaactaaat tttctaggct gaaagctgtc tatgttccat tttggcagaa aaagactttt     2460

ccagagatca tcgactacct ttatgagacg actctacctt tgctgaagga aaagttagaa     2520

aaaatgatgg agaaaaaagg cactaaaatc cagactcctg cagcacccaa gcaagttttc     2580

ccatttcgag acatctttta ttatgaagac gatagtgaag gacatagaaa aagaaagcga     2640

agg                                                                   2643


