                         LISTADO DE SECUENCIAS

<110>  Consejo Superior de Investigaciones Cientficas (CSIC)
 
<120>  Uso de anhidrasa carbnica II para la elaboracin de un 
       medicamento

<130>  ES1641.478

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  2
<211>  24476
<212>  DNA
<213>  Homo sapiens

<400>  2
tcttaccaaa gaaggatatt gagagactca gagtccaaga gggaagccag agacaggatt       60

aaatggtttt atagtcagaa gaagaagttt ggatctttct gtaaaggaag ttgtcagatg      120

aataaaagca aggagctagg caacagcgtg ttgtatctgg ggacttctac aagtctcctc      180

atctataaaa taaatagttg gaccaggtaa cctccaaact tcttttaatt ctacaatgat      240

atattgttgt ggtttgtatt atatcctccc agcacataat atacctgtgc ataagccact      300

ccctagtggc ttccctgcgc aactagtata aaatcctttc ttgctatcat tgtctgcaag      360

gctctgcagg ctgtagcccc tgactgtctc tgactccact acttgtcttt tcttcctcag      420

tcaccatgct tcagtcacaa gcttttctgt tctagaaact tcctttctca gggcctttat      480

acttgctgtt tcctctgcct gaaatgccct cccccagatc tttttttagt ggttcctcaa      540

atgtacttcc ttcaataggt tttctataac caccgcatct aaagtaggat ttcctcactc      600

attattcttt acctcattcc tgttttactt tcctcatact aattttcagt attggaaatt      660

tacttttgtt gtttattttg agtcatttat tgtacagtac ccccatccat ccccatgtaa      720

actctgtgag ggcaggagtc atgttgatct ggtttatggc tatagcctct gtgctgatgc      780

ctgacacata atagcattca gaatgattca ttgagtgaat ggatgatgag acaagttatc      840

ttgtgtagct cacctagcac atagaaaata ttaagcacaa aataggagct gagaaacatg      900

taacggtagt aatgataact gacattgatc aagctctaat tattggcact aggttaaatc      960

cttcacacac tgtatcatct tagtcctcac cacaactctg tgaggtaagt attattatta     1020

tcctagtttt atagatgagg aaactgaatc ttagcacaat caagaaattt gcccaaagtc     1080

acaaagctag taaattaacc cagattcaaa accaacctaa tttcagcaca atgttatttg     1140

ctaactataa tctgtaacaa aattatttac taacttctgc aaagtgaaac tgccattatc     1200

tccatttgga tttttcaaag tttataattt caaggagtac tatgtgagta actactatat     1260

gtatcttggg actcaggcta ggtaaagggt actaggtgcc taagatacag agataaataa     1320

tgtgacacag tactcaactt cagggggcac agtttaggaa gaaaaacata agcgtggtag     1380

aatggacatc tccatgaccc aaacactcct ctgtcctctc acaaaaaaaa acaaaacaaa     1440

acaaacaaaa aaacacctcc tgctgtggag actcattcct cttaaatgtt tcccatgaac     1500

ctggcccagg tgtttaattt tgcattcctt aaattatatt ctaactgttt agcactgtct     1560

aggagggact gaatagccat catttactga gtgcctacac gtgacaggtg atttatctat     1620

gctcactgac tgaattctta caacaatgag gtgagtgtca ttattcctgc tttacaaatg     1680

agcagtcaac agcttattgg ggcattggat tataacccaa tgattacaat agagtgtctg     1740

attacaatgc agaattgcca atattaggat agaaggatgt gtatgcaaag acctatggga     1800

gccccaagaa acaaatggct cttggccttc atagatattt atttattttt attttgtttg     1860

agacagtgtc ttcctgtttc ccagtctgga gtgcagtcgc atgatcatgg ctcactgcag     1920

cctcaacctc ctgggttccg atctgccgac cttagcctcc taagcagctg ggactacagg     1980

ggcacaccac catgcctggc taacttctta ttttttgtaa agatggggtt ttgccatgtt     2040

gcccaggctg gtcttgagct cctgacctca agcgatccgc ctgccttggc ctcccaaagt     2100

gctgggatta caggcgggag ccactgagtc cagccccaga tatctactta aacactataa     2160

tggtaacaaa tatgagaata tctggctttt tattagcttt ttaattaaat atttaataaa     2220

taatgtgtat ctcaccttgt aaaatatttt aacaatatct ttacattttt tgagaaaaag     2280

caaatacttt cacattttta ctaagaataa tatgttagaa gcttttttat tataataatt     2340

ggaacacaga ctttaagttt ttttacatta cattttcctg atatactgcc tgaatttttt     2400

tttttctggg gcaaagaaaa gtacttttct taagctactg tcagttcctt tacttaagat     2460

tattctgaaa tgaacccatc cttccctcta atggaaagat aggtacataa taagataagc     2520

acttttttta tttgaacaaa tccagtatta gagtagtctt ttgcagctag tgaatcatga     2580

cagcctgcta agaagaatgc cttcagtaaa ataaagttag gttgggactg accaacatga     2640

atgcataaag ttaactccat taaaaaaaat tgaccaggaa aataaaacaa tgctaagcca     2700

accactgtaa taccaaaaac gctgctaaaa aatttagatt gcttctgagt aaccaaaggt     2760

gaaccactct ccaccctgtg gtgaacatgt gacactctcc ctaacagcag ctctgtgggg     2820

agggcttgct cccactgaga attaattcac tttccagaag tgagagataa ggaaaaattc     2880

ccatgacaat aatccatttg gtgaactgca gtttggtggt gtttgaagtt ttacgcatat     2940

ttaagaatca aacatgctct tacttcatcc ctgttaggaa agccacaatc cagtttcacg     3000

gaaaatgaaa gacaaggatt cctgctgatc aaatcgcctg gctccctcca cagaatcccg     3060

ggaagccact ctacattcac aaactttgca ctcaattctt ggcacctatc aacgccatat     3120

ctccagggcc aagtgaagag tctcatagca actaagttaa tatttgaaaa ttatgtaaag     3180

aaacaaaatt acatcaatgg gccccaacag atacaatgca cctacagagg cacaaataaa     3240

agcttcttct ttgctacaaa ctccattttg taatggtcct aaaaatttaa aaactttatt     3300

gctgctttct tgcctaagaa ttccctgtga catcaaccca aaacccacat aagcagaagt     3360

acacaatttt ctagaatctt agaacaagta agtctaaaca tgaatcatat ttgtttggat     3420

gaaattgact gaaataaata gtaaagagtg attttgagat acatattgca aaaatgtcca     3480

ctaataactt atccttgtat ttatctgtat attttcaaag gtaagtaatg tgatgtcaag     3540

gccgacacaa tcacattaaa ctgtgtcctg cttccccaac tgtaactcta atactattgc     3600

cctcagagat tgcagagacc acagaaccga actccttccc acaaaccccc ggatttttct     3660

gtggcaaaat cccttgtagg aaatgaattc tctctatatc tcaaaacagc ctcacttacc     3720

cagtaggccc tgtaagcaca gtgtctcagg tccacaatac ttttagatgc ccaggaaaat     3780

gtttcctttt aaaataagaa caaaaaagaa aaaaattagg tgttggttaa agaaaatgtt     3840

taaatatata atattaagat atttatcttt atgtcagtgt tggtataaat gcgtgtttat     3900

gaaaaaggga cccaccaagg tgaaatgccg taggacccac aaatgtcata atgctggctg     3960

gcctcaaaat gtccttccta ttaaactatt ttgaatgatt cctaggtatg ccagatgcca     4020

atttttcttg gccagccagg gaacgtctca tgtctttgga agaaattatc tttctcttac     4080

tggattcttc tgagaaaagt gatttgttaa aagttttggt tatttcaaat caatatgtac     4140

tcaactagga cgtctcctca cccacgttaa ttttttaaag aggaggaaag taggagaaga     4200

tgagcgcttc atgtaaggct ctgccagcct acgaggaaat gcaatcctcc aggctcgccc     4260

gagcgtgggc tgcgggcagg ggactgtggg gccgttgtct cgttttattc cacggccgtg     4320

cagcagaggg cgcgtgcctc tcagcactca tgctgcgcgc tcccctgcgc ctctaggatc     4380

gtatccctat ttgccccaag gtcatagctc ctaacccagc ttgccagccc caggccgggg     4440

acaccagaga ctgagccctt cgcgctggag accccggcgc gggtggggcg ggagggctcc     4500

ggggccaaga gacaggtcac aatggggaca ggggacgaaa ggcgccgggg gtccgggtcc     4560

cgagcagtcc ccgccgccgc cagactccgc agccgggagg gggatggggt gcgcgtagag     4620

gctccgcggc ccgggttgga cggaggagcc caggagccac cgcagccgcc gcacgcccag     4680

agctccgagc ttcgctgcca gcccaggaca ccggggccct gccgtgggcc gaggggagcc     4740

gggcggcggg agaggagccc cggagccccg gagccccgga gccccgccgg gcgccagccg     4800

agagggcgtt ttccccgccc ccggagactc gcccgcccgg cccgccccgc cccgagcgcg     4860

gggagttcac ctccgcccgt caccacctcc ccttgtcgcc taggtccacc cgagccccct     4920

cccccgggcc gcccccgagc acgaagttgg cgggagccta taaaagctgg tgccggcgcg     4980

acccgcggac acacagtgca ggcgcccaag ccgccgccgc cagatcggtg ccgattcctg     5040

ccctgccccg accgccagcg cgaccatgtc ccatcactgg gggtacggca aacacaacgg     5100

tgagtgccgg cgacggccag cgcgggggcg ccccgatccc cgatccccga tccccgatcc     5160

ccgagcccgg atgccggccc ggggcccgca gcgcccgcac atgctgttta ccgcggccgc     5220

ggggagtgct ggaggctcag gtgcgccccg ggcgctcgct ccgctcgcgg ctccgcggcg     5280

ccggggatgt cccccttgcc ccagctgcga ggccactgtg gaggaatccc cgcgtccgcc     5340

ggaggcgcgt agggcccgag ggaggggagg cgcagccctg gccgcgggac ccgaggacag     5400

tccctcccgg gtcccgacct ggggatcatt ttaaccggac ctaggaggag gcgggaaagg     5460

gttgtaacgg aaaattctag ttgttgatcg cagagaaatt aagagactcc cctcccccct     5520

cccccacctt ccacccccac cccacccctc cagcttcagc accacctgtg gctaaggcgc     5580

tcagcacgaa ctgtcccggg gcattttcca gtgctggttt gaatccatgg ctctgatttc     5640

cgagttttcc cttcatctct cgacttctaa tgttaggggg tcggacatca ggaatcgggt     5700

tttatcttgg cctcagatct ggttcttcgg agccagcgga gcagaggagc atgcgtctgg     5760

cgcacctagc gcatctttgg agggtgtggg gcttcccagg tagtggggaa ccctgacggt     5820

taaaggtggg gtgggcccgg gcctgggcag tgaggaaagg atccagacct ccttgaatgt     5880

cttaagtgag cttgcatatc ccaaaatcgc aaccacaagc cctgacatta gtgtctgccc     5940

gatttcagtt gctgaatttc agtaaaacga ccttaaaata gctaatattt atatagcact     6000

cagtgatcta agagctttac atatatcgat tctaattctt acagcgacat ctatgaggta     6060

gatttctaat tatcccatat tacaaatgtg gaaactgagg cacagattac gtgttttccc     6120

aaaatttagc ccattgttaa gtgatgcttc taaaattgga actgagcaga ttggctccgg     6180

aatgattgct cttctctagg ggtctgggtg tacctttccc cacaatgggg gattcacatg     6240

tcttctttcc cccaggacct gagcactggc ataaggactt ccccattgcc aagggagagc     6300

gccagtcccc tgttgacatc gacactcata cagccaagta tgacccttcc ctgaagcccc     6360

tgtctgtttc ctatgatcaa gcaacttccc tgaggatcct caacaatggt catgctttca     6420

acgtggagtt tgatgactct caggacaaag caggtcagtg tttagaaaat aacttgtgtc     6480

ttttagccag tagctgtttt ccgagcttaa tggaaggagc caggaacagt ggcaggaacc     6540

ctcttaataa tacagtttgt ctcaggactc aaggatgcca ccctgatcat tttcattagg     6600

tctcagattc tgagaagtag gctaattagt ttgaagtgtc ccggggccgt ttcttccctg     6660

taaaaccctt ggcttctatg aaggccattg aataactgcg atatgcctgt gaaaaatcac     6720

aaaaggtgca aagtcccctc gcaataaaga tcagtcacga tgagatttgc accaattgaa     6780

cttttaagat tgtaaaatat tttgtcttgc agagctgatg catatccatt aaaaagtata     6840

tcttagtgag ccttatcttc aagttagcag cgagaagagt aacaaaaacg tgccaattta     6900

aaatactgaa attctgggaa aatgttttac ttatgagtat ttcttagtat tgggctagtg     6960

tgataaagat ggcagcatgt tttgatatct actcagaaat tcatttcaca aacgaagatg     7020

ttttagagtt ggtgaacata cctggcccat tactgacaaa accaattacc gtatttattg     7080

gtaatagagc tgtttacagg atgctcactg taaaaaaaaa aaaaaaaaga aagagaaaga     7140

agaaaaaaaa tcctgctttt ttttttttat ctctctctct tttgaaacaa gagaacaatc     7200

ccattcacac atagtagctg ccttctttgc taagcagtta atttaattgc cagtgcccta     7260

ttttcctgag tgctttcctc tgaaggtcat agaatgaaat ggtgctgcaa acacattttg     7320

tttggtggtg gtgtgggagt gaggggagtg gtggaacaaa atgagaaagt tttggagtag     7380

tgacctacgg tactaatata ttatataata tgtaattata accatttagt caggtagact     7440

attctttgtc agcagctatc ctatatagtc aacttggttt tgaaaaaaga attcttccct     7500

cctttcaact ttaaaaaaat ttgcaaacac ctggctttct gaaatggtga ttctggaaga     7560

caatttgatg ggggataatg tggagatcat ctgagaaatg ttttcaacct acctgtgcct     7620

gtctgtgtgc acccctcccc agtacacaca tacatacata catacacaca cacacacaca     7680

cacacacact tacaatcata ctcacacttt ctggcatagt atgatgattt attagaatca     7740

agtaaaggtt gtacattgaa aacagttcgg tgattctgct acattgcttt cccaagcatt     7800

cctctcactc caaaggaaca gtgctcatat aattaaatta aacaattttt ttcttgtaaa     7860

gaatactgta tatttataac aagacaaggc caaaggtctc aaggtattac acatacagaa     7920

agaatactat aacatttcac gtctagtcat ttacaaacca aaagaagtga gctactttag     7980

tctgtagctg tactttttta aagagccaca atgatgtcat tgttttcaat ggatgtaatg     8040

tctgccaaat tatgtatctc attggatgct acatagaaat tggatagttt aagtcttttt     8100

tggagcactg aagaaacaaa tctccaacaa atgaaagcag atgaggttcc taatagtcct     8160

taaaaaatgg atagtgaaat aaattattct agtaatatgt attactggaa agtggatttg     8220

aacacatggt ctggtggcta tcagcataga ctggggtcag agagacctgg atttgagttc     8280

tagagctgcc ggcaactagc tcagagactt tgggagtaat actgtctagg ttttaattgt     8340

ttttaactgt aaagttggag taacaatagt gtctgccaca gtggaaggat gaaatgggac     8400

agtatatgta aagcccctag cccagtgcct ggcgcataga agttgctcaa taaatggcct     8460

ctgttgttgt cacaacttga acccttcgac cacctctgtt agaccattgc tgtagatgtt     8520

gcacctgcga taagatttct gaataaactt tttctttaac agctttaaga ttagttccca     8580

tcatttgatg tattttaaat ttttattttt atattttctg aagcatactg tttatcatac     8640

tgaatatgta cttattttat gtatgaagtt attatatagt tacatatttt accatgaatc     8700

tgttaaactt tgacagattt ctctataagc agtaactaat tagatctagc tacatttttc     8760

acagctattt cttctggaga gcaatgcata catttttaaa gaagttggcc atgtttagat     8820

tgtgaaacag atgaaaacca cagggtttcg gtaggagctc ccacccatgc ctttagagac     8880

acatgtatta tccacctagt tctacaaaaa agtcattatt aacaccactt aaatgcatgg     8940

gaagctaagc atcatgaaag cagggtggag gcctggtccc tctcctgttc cccggagccc     9000

atgctggaaa tatctaaagt agaaagacat agaaatagta gaccctgact gccactttga     9060

taagtgcaga aaggaagtac tccaaggaac tatggaaacg tgaaggaggc ttggcagttt     9120

aactgataag acaggaaaga ctttccaggg taaataaggc ttatgtggag gcttgaagga     9180

ttttgatgtc ttggacgaga gtccaggcaa agggagatag gaaataccag gagacttaag     9240

agagcacagc atgtgctcca gaaaggcaag aaggtatact aaaagcaagg tcagaaagga     9300

cttgccctcc tttgcatatg aaagattcct ttgtaatttt gcctctcttt tccacatttt     9360

cagttacttt ggttaaacaa gaatgcagaa tatattaaaa tgtcaatatt aagagaaaag     9420

acatctacag aataaatttt taaaaatcat accatgtggg ggacaggcac ggtggctcac     9480

gcctgtagtc ccagcacttt ggaagactga ggtgggcgga tcacttgagg tcagaagttc     9540

aagaccagcc tggccaacag ggtgaaacac tgtctgtact aaaaatgcaa aaaatgagct     9600

aggtgttgtg gcatgtgcct gtaatcccag ctactcagga gactgaggca ggagaatcgc     9660

tggatcccgg gaggcggagg tcgcagtgag ccgagaccgc accactgcac tccagcctgg     9720

tgacagaacg agactccatc tcaaaacaaa caaacaaaca aaaaaccaca cacacacaca     9780

cacaaaacca tgtggaaaaa ctccctttag actttctttc tttttttttt ttttaaataa     9840

aacaatccta ggctctcaaa gccaaaacaa agaatagaga tactctagtt aaactcacct     9900

taataaacat gaagaaacag aagctgaaga gtttaaataa cttgctaagt cgtctccttg     9960

ctagtttgct ggagggacta agtagcaatc acttaaaaat agaattttga ataaaaatat    10020

ttgaaggata accttatttg acatttagtt tatacatacc atgtttttta aaagctggca    10080

tttttttctg tacacaagtc aaaaagttat ttattttagt cacttaattt taaaaaatcg    10140

gcagtttaac atctcttttt attaggagtt atttttgtgg tggtaacatt tttagatttc    10200

ctatacctct tatttcctgc atttaaatgc agttcattta cctgtcttct ttgcctcaat    10260

gagatttcag ccttctagaa cttctcatag attgaggttt tccaatatgc tttaaatgtt    10320

ctcttatatc caaacttaag aacttgggta tcaggaactg agcgggttga ctttattgct    10380

gatttaagct tgagagaatt ttttaaacta cggagttaat aggatttaac tagaaacttg    10440

ggttagagct ctcatcaatc ttctaaattc ctttgaaaat aagccaccat aaattcacct    10500

taagttaatg aaaaattgct aatcccttta ggttcttaaa aaacttatta aaaaataact    10560

caccctgctt gagatgtttt attaatggcc ttatctggga gaaaataata gtagtcaaat    10620

tattaactcc tgctaactta ttaactttta ttaatgagtt taatactctc ctgctttatt    10680

gcaaagttag ggacaaatat tgaaagtcaa tgccagaatt attgggccaa ctcttatcca    10740

agtcttacat catttctgtt tttcagaaat tggaattttt taaatctgtt tgttatttca    10800

agaaaagagt aaaggaagct ggatgagttt acctgtgctc tttttaagtg acccattgtc    10860

tgtatgacgt aatggatctt catacatgga tcctgcttga ctttcaggga cttgcttttg    10920

aagctctaaa agttttcttt cacagcagtc ctaagttaaa agaaagcata acaacaaatg    10980

aaagggcttg tcatgcacgc agtaatggtg tcagccgaac cttaaatatc tagaaaatgg    11040

accaacatat tctaaacact gtagttacta tattcacatc aaaacagctt ctttttttac    11100

tcctatataa ttgccacata gtttaaacca cgacttctgt tgaatttcaa ctgtgtttac    11160

tctagcgaaa gtgacagcta aacatcttat tgctttaaaa caaatggaat acgtgtattt    11220

tttcccccca gatttgtcta tattggcacg tagccctagg attattggct gctgccaaca    11280

ggcaaaacag taatgcatga tttaaaattt ttcaggttat ttatagaaaa gatggtaccg    11340

aaaatgacat gttttctgta gaattaatct tttgctttat tagtaggaaa tcatttaaat    11400

tttattttta aactaaagat tactgggact agtttattta tattttggac ttaggagaaa    11460

ctgttgacat tcattacggt ctttagtctg ttactccagt gcatcttaat ttagtttaag    11520

tgattaggga gaaaaaatta aaaaatatta aatgttcagc ttttaatttg tataagtaat    11580

gtgattcatt tcaatattac tggatttctt atttttctca aaaagtaatt tatataattt    11640

cctcaaataa tatgtatagg aagaaagatt attctataac attatactta gtgcttgttt    11700

tgtgttatat acagagtatg tataattgat gacaatcatg aaaattaaaa ttggctggag    11760

ctcttggtgt tgagatttga atttaaatta aattgggggg ggtcttgaaa aaaacattag    11820

agtagaaaac tgtatttatg tctccatccc tcacagaacc catttctggg gtacaatgaa    11880

tcattgactc tttaaagcac cactgccatg gctggatttt acagagaaaa aataggcagt    11940

tagcaatttc tgctattttt taaaattatt tttacattag aaaatagatt tcattttaaa    12000

ctgcaacagt ttagaaaatg gcatgtagtc atttaaataa ataagtagat ccagaatata    12060

gcataaagtc cctaacttaa accaagatat tatgttttat gtttctcaaa taaaaagttt    12120

gagtttatgg caatttatta taacaatgtt tttgaaggac ttcattgact aaactccatg    12180

ctaagagttt gccagaaatg ctgccttctg tagcaagtaa actttaagga tttaataaca    12240

ttttctagtt acagtgggtt tctaatcttc ataggaacaa gttttatttt aacaggggct    12300

aaaacaggta tctggtgata acagattagc actgaatgtg tttaatcatt gagcccagag    12360

cactttatct tttttttttt ttagtgttag ctgttagcaa gtattgttta ctaaaggttt    12420

gcacacactc ttgcctaatt ctaaatgttt ttagaaacaa attaagatga aactttaaga    12480

tttgttagag aaagaataag aaacagcaat aaactttatt ctccttaaaa tgtaagatcc    12540

tgctatgatt cttcactggg gggaaagaag atacatttag aaaattggtt atctcagatt    12600

cttagtatgg ttttagttag ttagttttac cacttggtag agttaatgat ttgacaaatg    12660

acatttgctt cttattatca gccagttggt tgctagcttt aaagagttat tataaaggat    12720

ttttttcagt attaatttat ttcataaaca tatatttaat ttttatatat tattatgaaa    12780

aaagggaatt atttcattct tttttaaaaa agtctagaat tagaggctaa tatttcctta    12840

tagaattgtc aggaaacaaa ctgttgtaat aagttgtttt tgtgttccaa gagatgtgac    12900

tttgtcagaa tacatccaaa ttcatatttc ttagcagatc tttaacataa caccatttat    12960

aattctttct gttttcattc ttcctttttt ctcctggcct attgtaaagc agatctggca    13020

gccagaggtt gtatcaggaa ccacagaaag accccactgc ttaaatatct tcaaagcagt    13080

ctttcacttt gaatagatga atggatattg ctaccatgta aggatattta ggtgaagctc    13140

atgaacaaat cttgttgtac agaagttatc cctttgttct gcaatgccaa agtaaatttg    13200

ggctcattat tttatggaat tataaagtaa agctaataaa atacacttat agcaacaaat    13260

gtttaattcc cagtactaga aaaataaaat ttaaattgta gaactaaact acttttaaaa    13320

gcttttgaat atattggtta aatcccatta atacatacaa agttaggcac agagtttctt    13380

ggtggatgga agaaagactg atttcacact attttaatcc tctgtcaaga cgcaacttat    13440

taattatata cagatagttt gtagccgatg gatgtgattt ttgttactga ttttgcttaa    13500

tgcagttaca ttaatgccag aatagtagaa tcgtggaata gttatcaagt tagaatttta    13560

agttcttgga gataatagag cacattacac tgcatataga agatgatcca taaattatta    13620

gtgaaatagt aaatgattta gtgtgtccac agatgagtaa attaaggtca aagaggttta    13680

ataaaaattt tcggccgggc acggtggctc atgcctgtaa tcccggcact ttaggaggcc    13740

gaggtggatg gattactcaa gctcaggagt tccagaccag cctgggaaac aaggcaagac    13800

tctgcctcta ctaaaaatac aaaaattaac tggacatggt ggtgcacacc tgtaatccca    13860

gctactcggg aggctgaggc acgagaatcg cttgaactct gcttgaggcg gaagttgcag    13920

tgagccgaga tcgcaccacc gcactccagc ctgggcaaca gagcaaagct ctgtttcaaa    13980

ataataataa taataataaa taaataaata aataaataaa taataaaaaa aattaaggga    14040

acaaagctag ccagcagcag tgagagtcta aattctaaag aatttgggaa gcctatataa    14100

ggataattgg attttgcaat gttaagatca atggaatact gatttcacaa attcgggtgt    14160

ctaagaactg gtatcagagg ttagcaaagc aggctgtatg gcagcaatcg ggccttggtg    14220

gaagagaggg tctcacgttt gcaagtgtgt gtagcagacc aatttattgg ccagtagctg    14280

catgggcact tcctaaatgt ttcacagatt attagtttca cttagaattt tctctctctg    14340

gacctgaatc tatgactcta aaacaaaccc agaaaaagga atcagtatgc tcagaaagaa    14400

agatgtgaaa aacatccatt ctccagacaa cgcatgtgag gaataaaaac aggtaaagtg    14460

attttgttca gcaccgtaga ctaaacttga ctctggattg aattttcaga gtaaaatgtg    14520

attaaaggca aacatttagt actgtaaaac agaattaaga ttgtaatatt taggcatgtg    14580

tttcatgtgt gtgtatgtat gtgtgtatac ctatgtatat atgtgtatgc agatacatac    14640

atatatgtta catatatata tatgttttaa ttttagtgct caagggagga cccctggatg    14700

gcacttacag attgattcag tttcactttc actggggttc acttgatgga caaggttcag    14760

agcatactgt ggataaaaag aaatatgctg cagaagtaag atatactttt ttttttcttt    14820

ccagggaaaa atgtttataa gttgatattt agcattaatt tcaaaagctt aatttgtaaa    14880

ttcaactcac gcccagtgaa ccacttcttt tacaaaggac cttcacattt gctttttata    14940

acctttaatt gtgacatcat acttaacgct gcaaaacttt ctctactgtc tccaactcca    15000

ccatttgcaa aaagtaaacg gactcaaact ggaggatcct gttttaacag aaatttagaa    15060

ataaaatgtg tgccttctgt caaaactgta catttatttg tcttagagtt attgatgaaa    15120

acacttgctg ttataccaag tactgtgtgg atgattagaa ttaaaatgaa aggaaaattt    15180

tgatttaaaa ttatccatat tttcaatttc ctgagtaacc tttattgtga gaaaaagacc    15240

attgaataaa atctgtcagc tttgattatg taaatcactc actgtggctt tgtctcttcg    15300

gccttagctt cacttggttc actggaacac caaatatggg gattttggga aagctgtgca    15360

gcaacctgat ggactggccg ttctaggtat ttttttgaag gttagttgat gacccaattc    15420

ttttttttcc ctatttttaa taaagaatga ccagacagag tatttgtaac atacaggaca    15480

ttctacaaaa gagcttagga aatgcctttg tccctgaaat gttttcaagt ttatctcctc    15540

ctttcatatc tgctagttgc agtggagatg gagggcagaa agacaatagg agaggtactt    15600

atttggtacc ttttggatgt aaatgtgaag aacataaaga gatcaacttg ggtgactgct    15660

aggtgtttgt ttgttttctt ttcatttaac ctgaggctag acagtactat attatgataa    15720

agtaagatca ggttctgaag aggggaagga cagtgaattt caggcaacag tgggacagaa    15780

ccggttgagc tgccctctaa acagtggtaa aggggaatgg agaaaggtct gggctggaga    15840

tttatgagct ctgattcata tgttgaggtg gaagctacag gtgtgtatga aatcatccaa    15900

gtacagcacg aagagggaga tgagaaatct gcccagggag caatcctgag aaactgcaaa    15960

atgtaaggcc tttacaaggg gagagatgca aattaaacaa cttaaaaggg gccaggtgtg    16020

gtggcttaag cctgtaatcc cagcaccttg ggacaccaag gcaggaggat agtttgaggc    16080

caggagctca agaccagcct gggcaacata gcacaattcc atctctacaa aattttttta    16140

aaaattagct gggcataaaa aacaaactaa caaacaaaaa aacaaaacaa aaacaaaaac    16200

acaaaattag ctgggcatgg tggtatacac ctgtagtttc agctacttgg gaagccaggg    16260

caggaaaatc actgcagcct aggggttgag gttgcagtga gctatgatca tgccactgca    16320

ctacaagctg gatgacagag caagactctg actctaaaaa aaaaaaaaaa aaaaaaaaaa    16380

gcgagagtca agagagattt gggttgctgg aaggcgtagg gaaagccaaa gaagaaaata    16440

atttttaaaa agaagggaag accatagtgt aaagtcctac aaggaaatca aggcaagccc    16500

ttgaggagta tcctttggca gttagaggtc actggggaca attgagctgg tggtttcagg    16560

actactctct gagtggaatt agaggcgagt tgaagattca gtgaaagtag gcaagtctat    16620

ggtgtcagtg tcatcaagcc agtactgatg ggggtcatgt atgaagtgga gaatttgggc    16680

tcactatttg gatgttttct aatagagcta cccaaataaa aataaaaact ggtacagtac    16740

caactgggtg atagtatctt gccctttatg tttttcttta ggttggcagc gctaaaccgg    16800

gccttcagaa agttgttgat gtgctggatt ccattaaaac aaaggtaaat ttgaattttc    16860

tgccacctcc ttagggtacc aattttcaat actccattgg ttttagaaat ttcttttgat    16920

caaattgcac agtctcaatg acatgtggtg tttggatgag cagttagtaa aggtagaata    16980

ttacttaaat atttaattaa cgtttctttc aacaaagttg atcctaatgc tagcataatt    17040

ctaagacttg tatttattta atcttgctcc cccatcattt ggacatccat atgtaagagt    17100

cagagaatct tatgcctgca aggaggttca aaggtcctct agtcaaatta ttcactcatt    17160

catacagcag atatttgtta agtatgtact atgtgccagt cgctttgcaa actagtagac    17220

acaatggtga acaagataaa caaggccctg tttcatggag atttctattc tatgacctct    17280

ttgcattcat ccatcctgca tttaaatcct ctctgcagca tagttgtgtt gaggtcgttg    17340

agcatctgtt taaacactac agtcacttcc ggtgatgggg aacttatcac caggggcagc    17400

cctggcttta taaagctgat cttcacattg aagcagcatc tatcctctga aatgctcact    17460

cactggcttg agccccttga attcatagaa taaacctgat ctctcttcca aataactcta    17520

ctctgtctct actttgtttt ttcacctacc ccaaactaat tatctttagt ttcctttaac    17580

tattctcata tgatatagtt ttctctcttt gccaccacct tgtcattctt ccagtaaatc    17640

attcctgttt gcttgaaaag tgtagtgtcc aaaacagaat gtagttattt gattctgacc    17700

tagagcaaga aaatcacctc ctcatcagga taccatattt ctgttattgc aacttgaagt    17760

cacctcattt tagtggcagc agtctcactt taaatactgg gtgtgatcag ctaatgactt    17820

aatggggaat gtaagggatc attttagata aaaggccaag atgaaaaatg gacatgtgaa    17880

aatagttttt tttttttttt actacgactt gccacatatt ttcaagttga atgtcttctg    17940

ttaatttctc tttattttgt ttgccagtga atatagaacc tcttttttaa aaagtgtttt    18000

tgaccatcag aggggagtat acctatttgt gtctgctgct ctcctacctt cctcctactc    18060

tgtcaatgtg atagtttgaa gctgcgtatt tgccttgttc tagggcaaga gtgctgactt    18120

cactaacttc gatcctcgtg gcctccttcc tgaatccttg gattactgga cctacccagg    18180

ctcactgacc acccctcctc ttctggaatg tgtgacctgg attgtgctca aggaacccat    18240

cagcgtcagc agcgagcagg tttgttttgt aatgacaggt ctgtttacgg gtggagcatt    18300

tagtcaaggc agaagacctt ggcctccaga gtgagagaga actgagattt aatccttctc    18360

ctgctacttc ttgctatgga aatagtgcct ttgatggtgc ctagcaaata aacagcgttc    18420

agtaaatctt tgttgttatt aactataaac ttagttcgtt tagtctctaa aattgaatag    18480

tcattgtaag gattcaatga gaaagatgtc tgtcacctaa taaatgcctt tttttttttt    18540

tgccagttat gaggaaacta aggcttagaa aagtgagagt tcatattcaa ggttacgcag    18600

gtatcagtga gttaccagcc tactactcac tcacataagg gctttctgct attttattta    18660

tatcagaatg catttctgaa tcctgacaga tgagagtcat cccttggaga acatgtatct    18720

attaaaactc actccaggtt gctttagagg cttagagcag gtattcttac atttccaata    18780

aaatatagtg tgtgatcgtc aagtgattag tgcagcttct aagtcactga tgagcagcca    18840

ctaaagtgga tacaaatgag tttttcctag acttacctct tagcgcacag ttgaaatgta    18900

gaaagtgaac attccttagg attcacaaga ggatggatcc tgaataattt aaggatagct    18960

ttaggagcca acagtcttga aaatggtaac tatgtgagta gtggtagtgt gatttaaacc    19020

tacaaaaatg ctgaataata gaggtttaga gctgcaatgt gcaatagaga tcatgttgtc    19080

caactttctc atttcactgg cttgaatcac attgatcaac agtctgagat gcaggaaaat    19140

tgaagtgttt tccactcagc taccttgcaa cagaatcagg cctgggagca aggattctat    19200

tcctgtgtcc tcccttagaa tatgaactta tgaatgctga agatacttca tatctttctt    19260

taaaggaaat atgtatctga ctggaaaatt acttgtagca tatcaaagtg ggcctaaaaa    19320

atagcatgct tggtatgtca cttgaagatt gaccttgtag taataacata tttgagtaag    19380

cttcttgaag tgtagcgtaa ggaaagatta taatgccctt ctttttgtag atgcagtgtt    19440

tacattataa tttaaaacat gaattttttt ttcttctttc actgagagca atgcaacttt    19500

aaagcaatag tctgacattt agagccatta taacaaatgg atttatggtg tatacacacc    19560

cacaggcaga aatacacata tagataaggg cagttgaacc tactgcatta atccctgtac    19620

cctgagtttg ctctttaaag ttgaaagtgg tattaaacta atgatgttaa ttgtatatat    19680

tggcaaaata ccaatagggc tctttttttt gtcctataac atggaatctg gaggaaggat    19740

catgctcagc tcaggaagct agggctgcag gtcctcctct atctgagtcc cttgacttgg    19800

ccttgccaat tggtgacttc atcctcaagg tggttgtaat agcattttga gcatcacatc    19860

tagatataac cacttcttga ggaggaaatg aatacctctt ccattggctt cctaagagca    19920

gagaagctct ttcctgaagg cccctagaaa acctttcact tctcactggc tagaattgtg    19980

tttcttgctc agtccctagc ccgggaatgt gatcatcaca gtcagttaag acctgcaggt    20040

ttaccccact gaggcttaca gggagagggc ggatgtctgt taatgaggaa gtatgggggg    20100

gcgtggattt taggtaagca gtataaatgg gtctgctaat tctgctacct ttattttcta    20160

tacccaggct ctgtctctgt gatgctaaaa caatgagtca agttgactaa tgtgacagtg    20220

tagtttaatt ggtgcagtga gtagcagaaa tcggttatac tggtttgatc aaaagtttga    20280

cctgtttaca ctttatgaac agactctctt tcagattgct ggaattctgt tgtaacgaat    20340

caaccctata tatccttaga atgctccctt gcattcagta accatagctg tgcatgttat    20400

aatgtatgtg catggaaggt ggctctacgg gggtgattga gggactatta ctggacaaaa    20460

gagatcaggt taaaggctgt tgattcatgg gctgctatat tactgtccaa accacccttt    20520

tgcatttgga tcacgtcttg gttagagggg ggaaagtagc actttttgag aaccttgaag    20580

aagtgggaga ctgttcaaca gctgcctgta tctcagtggt ggccagtaaa ctgaaacaag    20640

tttataaggg aataaaaatc aaccagtgac aaggggttct aatgttaaat gcatatattg    20700

gcaaaatgcc agtagggcta tgtagggtgg tgagcactca caattgttca ctaaaatgct    20760

gtttttaaaa caggaaagta gaatggttga gtgcaaatcc atagcatgag ataaattgag    20820

cttcttaagg caaatcagcc taggcaaatt catttccgtg tttttgtgta tttggagatg    20880

ccagctcgtc actcagccca tggagcttac aggtcctgat cacttgatct aattgtatgg    20940

atgtggtagt ttgtcttccc tggggcagaa aacaaagctt taatttggaa ctaaaattgt    21000

tattattttg catctaaagg tatgagttta tagacttttg atgttagatt tttaaattag    21060

aaggtcactg aaaatttccc ttaaaaatga ccccaacgaa tttgtgtatt ttgtataaat    21120

tggtttgtta tattaaagca tacatacata atctatatgt gattatgtat tcattaggaa    21180

tcaaactgaa ttttggccat tgatgcacag cactgaatgt tgtggaatgt aatttttgtt    21240

tgtttttgtt tctgtttttt gaggcagagc cttgctctgt cgcctaggct ggagtgcagt    21300

ggcgcaatct cagctcattg caatctctgc ctccagggtt taaatgattc ttgtgcctta    21360

gcctcctgag tagctgagat tacaggtgct ctaccacgcc tgtttaattt ttgtgtgtgt    21420

gtgtgtgtgt tttttttttt gtagagacag ggtttcacca tgttggccag gctggtctcg    21480

aattgctgac ctcaagtgat ccacccgcct catgcctcag ccttacaaag tgctgggatt    21540

acaggcatga gccactgcgc ctggccgggg aatgtattta aagatataac acaagtatat    21600

aactgaatac cattgtgaaa cattaattat caatgtttta ttgtgtcttt taggtgttga    21660

aattccgtaa acttaacttc aatggggagg gtgaacccga agaactgatg gtggacaact    21720

ggcgcccagc tcagccactg aagaacaggc aaatcaaagc ttccttcaaa taagatggtc    21780

ccatagtctg tatccaaata atgaatcttc gggtgtttcc ctttagctaa gcacagatct    21840

accttggtga tttggaccct ggttgctttg tgtctagttt tctagaccct tcatctctta    21900

cttgatagac ttactaataa aatgtgaaga ctagaccaat tgtcatgctt gacacaactg    21960

ctgtggctgg ttggtgcttt gtttatggta gtagtttttc tgtaacacag aatataggat    22020

aagaaataag aataaagtac cttgactttg ttcacagcat gtagggtgat gagcactcac    22080

aattgttgac taaaatgctg cttttaaaac ataggaaagt agaatggttg agtgcaaatc    22140

catagcacaa gataaattga gctagttaag gcaaatcagg taaaatagtc atgattctat    22200

gtaatgtaaa ccagaaaaaa taaatgttca tgatttcaag atgttatatt aaagaaaaac    22260

tttaaaaatt attatatatt tatagcaaag ttatcttaaa tatgaattct gttgtaattt    22320

aatgactttt gaattacaga gatataaatg aagtattatc tgtaaaaatt gttataatta    22380

gagttgtgat acagagtata tttccattca gacaatatat cataacttaa taaatattgt    22440

attttagata tattctctaa taaaattcag aattctattc tgggttattt atttatttat    22500

ttttattata ctttaagttt tagggtacat gtgcacaacg tgcagatttg ttacatatgt    22560

atacatgtgc catgttggtg tgctgcaccc attaactagt catttagcat taggtatatc    22620

tcctaatgct atccctcccc actcccccaa ccccacgaca ggccccagtg tgtgatgttc    22680

cccttcctgt gtccatgtgt tctcattgtt caattcccac ctatgagtga gaacatgtgg    22740

tgtttggttt tttgtccttg tgatagtttg ctgagaataa tggttcccag tttcatccgt    22800

gtccctacaa aggacatgaa ctcatccttt tttatggctg catagtattt catggtgtat    22860

atgtgccaca ttttcttaat ccagtctatc attgttggac atttgggttg gttccaagtc    22920

tttgctattg tgaatagtgc tgcaataaac ataggtgtgc atgtgtcttt atagcagcat    22980

gatttataat cctttgggta tatacccagt aatgggatgg ctgggtcaaa tggtatttct    23040

agttctagat ccctgaggaa tcgccacact gacttccaca atgattgaac tagtttacag    23100

tctgaccaac agtgtaaaag tgttcctatt tcttcacatc ctctccagca cctgttgttt    23160

cctgactttt taatgattgc cattctaact ggtgtgagat ggtatctcat tgtggttttg    23220

atttgcattt ctctgatggc cagtgatggt gagcattttt tcatgtgtct tttggctgca    23280

tatatgtctt cttttgagaa gtgtctgttc atatcctttg cccacttttt gatagggttg    23340

tttgtttttt tcttgaaatt tgtctgagtt cattgtagat tctggatatt agccctttgt    23400

cagatgagta ggttgcaaaa attttctccc attttgtagg ttgcctgttc actctgatgg    23460

tagtttcttt tgctgtgcag aagctcttta gtttaattag atcccatttg tcaattttgg    23520

cttttgttgc cattgctttt ggtgttttag acatgaagtc cttgcccatg cctatgtctt    23580

gaatggtatt gcctaggttt tcttctacgg tttttatggt tttaggccta acatttaagt    23640

ctttaatcca tcttgaatta atttttgtaa aagatgtaag gaagggatcc agtttcagct    23700

ttctacatat ggctagtcag ttttcccagc accatttatg aaatagggaa tcctttcccc    23760

atttcttgtt tttgtcaggt ttgtcaaaat attctgggtt attttattgt gtactgagtg    23820

gtgggtaata cagtaatgga ggaacaaatg tctactttta caattcacaa taattcctta    23880

ttaataatga gccatcttaa ttggcttact gataattgaa aaagtctcca gaaaaggaaa    23940

aactctggaa gtcatttact tattatgcca agtacggttt taagtgctgt ctgagcattc    24000

atgtgatctt cctgacaatc ctatgaagat taatcctgca agagaaatga ttacattaaa    24060

agtagcaagg tagagaaggg ggaagagtgt gcacactgaa tcaatataag ccccttggga    24120

aaaaaataaa taaaagttca ttttattcaa aaagggaatt ctagtgatat ccagaagtga    24180

aagaataatt tgaattttaa aaagagaaat taagctgagc atggtggctc actactgtat    24240

tcccagtact ttgggaggct gaggcaggat gattgcctta ggctgggagt ttgagaccag    24300

cctaggcaac atagcgaggc ttcatctcta caaaaaatgt aaaaattatt tgagtgtggt    24360

gttgcatacc tatagtcata gctatttgga tgtctcgggc agaaggatca cataagccca    24420

ggcattcaag gctgtagtaa gctatgattg catcactgta ctccagtctt ggtgat        24476


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo de PCNA

<400>  3
aggacggggt gaagttttct                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso de PCNA

<400>  4
cagtggagtg gcttttgtga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo de Estatmina

<400>  5
cttgcgagag aaggacaagc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso de Estatmina

<400>  6
cggtcctaca tcggcttcta                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo de GAPDH

<400>  7
cccccaatgt atccgttgtg                                                   20


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso de GAPDH

<400>  8
tagcccagga tgatgccctt tagt                                              24


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo de Ki-67

<400>  9
agacgtgact ggttcccaac                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso de Ki-67

<400>  10
actgcttccc gagaactgaa                                                   20


