                       LISTADO DE SECUENCIAS

<110>  UNIVERSITAT AUTNOMA DE BARCELONA
        
<120>  Composiciones de terapia gnica para prevenir y/o tratar enfermedades autoinmunes

<130>  PCT-03866

<160>  6    

<170>  PatentIn version 3.5

<210>  1
<211>  6407
<212>  ADN
<213>  Artificial

<220>
<223>  plsmido codificante para IGF-I bajo el control del promotor hbrido CAG

<220>
<221>  promotor
<222>  (1)..(645)
<223>  Promotor Hbrido CAG 

<220>
<221>  Intron
<222>  (646)..(1611)
<223>  Intrn beta-actina de pollo

<220>
<221>  CDS
<222>  (1805)..(2500)
<223>  IGF-I-murino

<220>
<221>  seal polyA
<222>  (3341)..(3473)
<223>  SV40

<220>
<221>  caracterstica
<222>  (3596)..(3194)
<223>  WPRE

<220>
<221>  caracterstica
<222>  (4313)..(5170)
<223>  gen bla, de resistencia a antibiticos

<400>  1
ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc       60

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      120

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      180

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      240

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      300

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      360

ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      420

ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg      480

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      540

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc      600

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc      660

cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg      720

cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct      780

tggtttaatg acggcttgtt tcttttctgt ggctgcgtga aagccttgag gggctccggg      840

agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg cgtgtgtgtg tgcgtgggga      900

gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc      960

tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg gggcggtgcc ccgcggtgcg     1020

gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg     1080

ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc cccctccccg agttgctgag     1140

cacggcccgg cttcgggtgc ggggctccgt acggggcgtg gcgcggggct cgccgtgccg     1200

ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg ggccggggag     1260

ggctcggggg aggggcgcgg cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc     1320

cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa     1380

atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg gcgcggggcg     1440

aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc     1500

cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg     1560

gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc tagagcctct     1620

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt     1680

gtgctgtctc atcattttgg caaagaattg attaattcga gcgaacgcgt cgagtcgctc     1740

ggtacgattt aaattgaatt ggcctcgagg tcgacggtat cgataagctt gatatcgaat     1800

tccg tag atg ctt tca caa acc cca ccc aca aaa caa cac atg ttc tta      1849
         Met Leu Ser Gln Thr Pro Pro Thr Lys Gln His Met Phe Leu          
         1               5                   10                           

agt cct cag ttt tgt gtt cac ctc ggc ctc ata gta ccc act ctg acc       1897
Ser Pro Gln Phe Cys Val His Leu Gly Leu Ile Val Pro Thr Leu Thr           
15                  20                  25                  30            

tgc tgt gta aac gac ccg gac cta cca aaa tga ccg cac ctg caa taa       1945
Cys Cys Val Asn Asp Pro Asp Leu Pro Lys     Pro His Leu Gln               
                35                  40                                    

aga tac aca tca tgt cgt ctt cac acc tct tct acc tgg cgc tct gct       1993
Arg Tyr Thr Ser Cys Arg Leu His Thr Ser Ser Thr Trp Arg Ser Ala           
45                  50                  55                  60            

tgc tca cct tca cca gct cca cca cag ctg gac cag aga ccc ttt gcg       2041
Cys Ser Pro Ser Pro Ala Pro Pro Gln Leu Asp Gln Arg Pro Phe Ala           
                65                  70                  75                

ggg ctg agc tgg tgg atg ctc ttc agt tcg tgt gtg gac cga ggg gct       2089
Gly Leu Ser Trp Trp Met Leu Phe Ser Ser Cys Val Asp Arg Gly Ala           
            80                  85                  90                    

ttt act tca aca agc cca cag gct atg gct cca gca ttc gga ggg cac       2137
Phe Thr Ser Thr Ser Pro Gln Ala Met Ala Pro Ala Phe Gly Gly His           
        95                  100                 105                       

ctc aga cag gca ttg tgg atg agt gtt gct tcc gga gct gtg atc tga       2185
Leu Arg Gln Ala Leu Trp Met Ser Val Ala Ser Gly Ala Val Ile               
    110                 115                 120                           

gga gac tgg aga tgt act gtg ccc cac tga agc cta caa aag cag ccc       2233
Gly Asp Trp Arg Cys Thr Val Pro His     Ser Leu Gln Lys Gln Pro           
    125                 130                     135                       

gct cta tcc gtg ccc agc gcc aca ctg aca tgc cca aga ctc aga agg       2281
Ala Leu Ser Val Pro Ser Ala Thr Leu Thr Cys Pro Arg Leu Arg Arg           
    140                 145                 150                           

aag tac att tga aga aca caa gta gag gaa gtg cag gaa aca aga cct       2329
Lys Tyr Ile     Arg Thr Gln Val Glu Glu Val Gln Glu Thr Arg Pro           
155                     160                 165                           

aca gaa tgt agg agg agc ctc cca cgg agc aga aaa tgc cac atc acc       2377
Thr Glu Cys Arg Arg Ser Leu Pro Arg Ser Arg Lys Cys His Ile Thr           
170                 175                 180                 185           

gca gga tcc ttt gct gct tga gca acc tgc aaa aca tcg aaa cac cta       2425
Ala Gly Ser Phe Ala Ala     Ala Thr Cys Lys Thr Ser Lys His Leu           
                190                     195                 200           

cca aat aac aat aat aag tcc aat aac att aca aag atg ggc att tcc       2473
Pro Asn Asn Asn Asn Lys Ser Asn Asn Ile Thr Lys Met Gly Ile Ser           
                205                 210                 215               

ccc aat gaa ata tac aag taa aca ttc cgaattcctg cagtggccat             2520
Pro Asn Glu Ile Tyr Lys     Thr Phe                                       
            220                                                           

tttttggctg ggcacccggg tcgccatcca aaaaatggcc aggatccact agttctagag     2580

cggccgcaag aattcccgat aatcaacctc tggattacaa aatttgtgaa agattgactg     2640

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt     2700

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc     2760

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt     2820

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga     2880

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct     2940

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga     3000

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct     3060

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc     3120

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg     3180

cctccccgca tcgggaattc gagctcggta cccgggaatc aattcactcc tcaggtgcag     3240

gctgcctatc agaaggtggt ggctggtgtg gccaatgccc tggctcacaa ataccactga     3300

gatcggccgc ttccctttag tgagggttaa tgcttcgagc agacatgata agatacattg     3360

atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt     3420

gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca     3480

attcgatatc aagcttatcg ataccgtcga cctcgagggg gggcccggta cccaattcgc     3540

cctatagtga gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg     3600

aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc     3660

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg     3720

aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     3780

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     3840

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     3900

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     3960

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4020

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     4080

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     4140

aatttaacgc gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg     4200

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     4260

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     4320

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     4380

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     4440

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     4500

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     4560

cgccgggcaa gagcaactcg gtaggcgcat acactattct cagaatgact tggttgagta     4620

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     4680

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     4740

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     4800

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     4860

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     4920

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     4980

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     5040

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     5100

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     5160

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     5220

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     5280

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     5340

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     5400

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     5460

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     5520

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     5580

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     5640

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     5700

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     5760

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     5820

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     5880

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     5940

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     6000

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     6060

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     6120

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     6180

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     6240

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     6300

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa     6360

ccctcactaa agggaacaaa agctggagct ccaccgcggt ggcggcc                   6407


<210>  2
<211>  4749
<212>  ADN
<213>  Artificial

<220>
<223>  plsmido portador del gen IGF-I expresado bajo el control del promotor murino CD68

<220>
<221>  promotor
<222>  (1)..(720)
<223>  promotor CD68
 
<220>
<221>  CDS
<222>  (1013)..(1396)
<223>  CDS para IGF-I

<220>
<221>  seal polyA
<222>  (1674)..(1806)
<223>  SV40

<220>
<221>  caracterstica
<222>  (2646)..(3506)
<223>  gen bla, resistencia a ampicilina

<400>  2
ctagttgatt actgaatttg ccatgttgct tcctgcaata ccaaatgacc cacattacta       60

acatttggta atttgcctca gtgttaggca caagacatga gtgaaacttg ctgcattaag      120

acttaaactg gctgggtatg gtggcgcaag cctttaatcc cagcattctg ccggaggcag      180

aagcaggtgg atttctgagt tcgaggctag cctggtctac aaaagtgagt tccaggacag      240

ccaaggctac acaaaatacc tgtcttgaaa aaccaaaaaa aaaaaattca actggttggt      300

taggcctagc ccagatgatg taggtgtcaa ctcaccttgg ggatgtaggg agatggttgt      360

tctgtagctc ttcctgtcct gcaactaaat aaataggcta agctgacctc ttacatctgc      420

cttcggcctc ctgtgctagg attggagtgc atgggtgggg ttgcatttct taccaatgag      480

gaaagggctt cccatttctc tgctgcattg taagctccca agtagagcaa gttttgctta      540

ggtaagttcc gtgtgagtca gctgcctcat tctcacgagg taaccaaggc tttgtaccgc      600

ccactgagaa cgtcactgcc aatcacagcc taattgtgaa aaccaatggc ttgagtgggt      660

tgctaaagct gaggtgtctg agtcaggttt ggggtgggat tattttagtt aagggaagtg      720

aggcttttca tttcctcttc caagagaagg caaaggggat tggattgagg aaggaactgg      780

tgtagcctag ctggtctgag catctcttct agcctcgacc tcgaggtcga cggtatcgat      840

aagcttgata tcgaattccg aagatgcttt cacaaacccc acccacaaaa caacacatgt      900

tcttaagtcc tcagttttgt gttcacctcg gcctcatagt acccactctg acctgctgtg      960

taaacgaccc ggacctacca aaatgaccgc acctgcaata aagatacaca tc atg tcg     1018
                                                          Met Ser         
                                                          1               

tct tca cac ctc ttc tac ctg gcg ctc tgc ttg ctc acc ttc acc agc       1066
Ser Ser His Leu Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser           
        5                   10                  15                        

tcc acc aca gct gga cca gag acc ctt tgc ggg gct gag ctg gtg gat       1114
Ser Thr Thr Ala Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp           
    20                  25                  30                            

gct ctt cag ttc gtg tgt gga ccg agg ggc ttt tac ttc aac aag ccc       1162
Ala Leu Gln Phe Val Cys Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro           
35                  40                  45                  50            

aca ggc tat ggc tcc agc att cgg agg gca cct cag aca ggc att gtg       1210
Thr Gly Tyr Gly Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val           
                55                  60                  65                

gat gag tgt tgc ttc cgg agc tgt gat ctg agg aga ctg gag atg tac       1258
Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr           
            70                  75                  80                    

tgt gcc cca ctg aag cct aca aaa gca gcc cgc tct atc cgt gcc cag       1306
Cys Ala Pro Leu Lys Pro Thr Lys Ala Ala Arg Ser Ile Arg Ala Gln           
        85                  90                  95                        

cgc cac act gac atg ccc aag act cag aag gaa gta cat ttg aag aac       1354
Arg His Thr Asp Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn           
    100                 105                 110                           

aca agt aga gga agt gca gga aac aag acc tac aga atg tag               1396
Thr Ser Arg Gly Ser Ala Gly Asn Lys Thr Tyr Arg Met                       
115                 120                 125                               

gaggagcctc ccacggagca gaaaatgcca catcaccgca ggatcctttg ctgcttgagc     1456

aacctgcaaa acatcgaaac acctaccaaa taacaataat aagtccaata acattacaaa     1516

gatgggcatt tcccccaatg aaatatacaa gtaaacattc cgaattcctg cagtggccat     1576

tttttggctg ggcacccggg tcgccatcca aaaaatggcc aggatccact agttctagag     1636

cggccgcttc cctttagtga gggttaatgc ttcgagcaga catgataaga tacattgatg     1696

agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg     1756

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     1816

cgatatcaag cttatcgata ccgtcgacct cgaggggggg cccggtaccc aattcgccct     1876

atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa     1936

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     1996

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     2056

gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     2116

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     2176

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     2236

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     2296

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     2356

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     2416

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     2476

ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa     2536

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     2596

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     2656

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     2716

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     2776

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     2836

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc     2896

cgggcaagag caactcggta ggcgcataca ctattctcag aatgacttgg ttgagtactc     2956

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     3016

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     3076

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     3136

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat     3196

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     3256

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     3316

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat     3376

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag     3436

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa     3496

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca     3556

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc     3616

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc     3676

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc     3736

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt     3796

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt     3856

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc     3916

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa     3976

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac     4036

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg     4096

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga     4156

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact     4216

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa     4276

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc     4336

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     4396

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     4456

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     4516

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     4576

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     4636

ataacaattt cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc     4696

tcactaaagg gaacaaaagc tggagctcca ccgcggtggc ggccgctcta gaa            4749



<210>  3
<211>  19
<212>  ADN
<213>  Secuencia Artificial

<220>
<223>  Cebador directo GFP

<400>  3
aagttcatct gcaccaccg                                                    19


<210>  4
<211>  21
<212>  ADN
<213>  Secuencia Artificial

<220>
<223>  Cebador inverso GFP

<400>  4
tccttgaaga agatggtgcg c                                                 21


<210>  5
<211>  21
<212>  ADN
<213>  Secuencia Artificial

<220>
<223>  Cebador directo IGF-I

<400>  5
ctgggcaacg tgctggttat t                                                 21


<210>  6
<211>  24
<212>  ADN
<213>  Secuencia Artificial

<220>
<223>  Cebador inverso IGF-I

<400>  6
gggtttgtga aagcatctac ggaa                                              24


