                         LISTADO DE SECUENCIAS

<110>  Centro Nacional de Investigaciones Cardiovasculares (CNIC)
       Universidad Autnoma de Madrid (UAM)
 
<120>  Mtodo de identificacin de compuestos inmunomoduladores para la 
       piel

<130>  ES1997.3

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asn Arg Ser Ser Phe Ser Arg Leu Thr Trp Phe Arg Lys Gln 
1               5                   10                  15      


Arg Lys Ala Val Val Ser Thr Ser Asp Lys Lys Met Pro Asn Gly Ile 
            20                  25                  30          


Leu Glu Glu Gln Glu Gln Gln Arg Val Met Leu Leu Ser Arg Ser Pro 
        35                  40                  45              


Ser Gly Pro Lys Lys Tyr Phe Pro Ile Pro Val Glu His Leu Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ile Arg Ser Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu 
65                  70                  75                  80  


Phe Asn Ser Leu Pro Ser Gly His Ile Gln Gly Thr Phe Glu Leu Ala 
                85                  90                  95      


Asn Lys Glu Glu Asn Arg Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro 
            100                 105                 110         


Asn Asp His Ser Arg Val Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys 
        115                 120                 125             


Ser Asp Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn 
    130                 135                 140                 


Lys Phe Ile Ala Ala Gln Gly Pro Lys Gln Glu Thr Val Asn Asp Phe 
145                 150                 155                 160 


Trp Arg Met Val Trp Glu Gln Lys Ser Ala Thr Ile Val Met Leu Thr 
                165                 170                 175     


Asn Leu Lys Glu Arg Lys Glu Glu Lys Cys His Gln Tyr Trp Pro Asp 
            180                 185                 190         


Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Cys Val Glu Asp Cys 
        195                 200                 205             


Val Val Leu Val Asp Tyr Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln 
    210                 215                 220                 


Leu Pro Asp Gly Cys Lys Ala Pro Arg Leu Val Ser Gln Leu His Phe 
225                 230                 235                 240 


Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu 
                245                 250                 255     


Lys Phe Leu Lys Lys Val Lys Thr Leu Asn Pro Val His Ala Gly Pro 
            260                 265                 270         


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
        275                 280                 285             


Val Ile Asp Ala Met Met Ala Met Met His Ala Glu Gln Lys Val Asp 
    290                 295                 300                 


Val Phe Glu Phe Val Ser Arg Ile Arg Asn Gln Arg Pro Gln Met Val 
305                 310                 315                 320 


Gln Thr Asp Met Gln Tyr Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr 
                325                 330                 335     


Tyr Leu Tyr Gly Asp Thr Glu Leu Asp Val Ser Ser Leu Glu Lys His 
            340                 345                 350         


Leu Gln Thr Met His Gly Thr Thr Thr His Phe Asp Lys Ile Gly Leu 
        355                 360                 365             


Glu Glu Glu Phe Arg Lys Leu Thr Asn Val Arg Ile Met Lys Glu Asn 
    370                 375                 380                 


Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala Arg Val Ile 
385                 390                 395                 400 


Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser Met Lys Arg 
                405                 410                 415     


Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr 
            420                 425                 430         


Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gln Gly Pro Leu Ala His Thr 
        435                 440                 445             


Val Glu Asp Phe Trp Arg Met Ile Trp Glu Trp Lys Ser His Thr Ile 
    450                 455                 460                 


Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln 
465                 470                 475                 480 


Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile Thr Ile Glu 
                485                 490                 495     


Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu 
            500                 505                 510         


Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg Val 
        515                 520                 525             


Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro Ala 
    530                 535                 540                 


Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln Gln 
545                 550                 555                 560 


Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala 
                565                 570                 575     


Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg Val 
            580                 585                 590         


Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu Arg 
        595                 600                 605             


Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys 
    610                 615                 620                 


Tyr Lys Val Val Gln Asp Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn 
625                 630                 635                 640 


Phe Lys 
        


<210>  2
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  3
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  4
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  5
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asn Ser Met Lys Ser Thr Pro Ala Pro Ala Glu Arg Pro Leu 
1               5                   10                  15      


Pro Asn Pro Glu Gly Leu Asp Ser Asp Phe Leu Ala Val Leu Ser Asp 
            20                  25                  30          


Tyr Pro Ser Pro Asp Ile Ser Pro Pro Ile Phe Arg Arg Gly Glu Lys 
        35                  40                  45              


Leu Arg Val Ile Ser Asp Glu Gly Gly Trp Trp Lys Ala Ile Ser Leu 
    50                  55                  60                  


Ser Thr Gly Arg Glu Ser Tyr Ile Pro Gly Ile Cys Val Ala Arg Val 
65                  70                  75                  80  


Tyr His Gly Trp Leu Phe Glu Gly Leu Gly Arg Asp Lys Ala Glu Glu 
                85                  90                  95      


Leu Leu Gln Leu Pro Asp Thr Lys Val Gly Ser Phe Met Ile Arg Glu 
            100                 105                 110         


Ser Glu Thr Lys Lys Gly Phe Tyr Ser Leu Ser Val Arg His Arg Gln 
        115                 120                 125             


Val Lys His Tyr Arg Ile Phe Arg Leu Pro Asn Asn Trp Tyr Tyr Ile 
    130                 135                 140                 


Ser Pro Arg Leu Thr Phe Gln Cys Leu Glu Asp Leu Val Asn His Tyr 
145                 150                 155                 160 


Ser Glu Val Ala Asp Gly Leu Cys Cys Val Leu Thr Thr Pro Cys Leu 
                165                 170                 175     


Thr Gln Ser Thr Ala Ala Pro Ala Val Arg Ala Ser Ser Ser Pro Val 
            180                 185                 190         


Thr Leu Arg Gln Lys Thr Val Asp Trp Arg Arg Val Ser Arg Leu Gln 
        195                 200                 205             


Glu Asp Pro Glu Gly Thr Glu Asn Pro Leu Gly Val Asp Glu Ser Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Leu Arg Glu Ser Ile Ala Ser Tyr Leu Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Asn Thr Ser Phe Asp Arg Lys Lys Lys Ser Ile Ser Leu 
                245                 250                 255     


Met Tyr Gly Gly Ser Lys Arg Lys Ser Ser Phe Phe Ser Ser Pro Pro 
            260                 265                 270         


Tyr Phe Glu Asp 
        275     


<210>  6
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Ala His Asn Gln Val Ala Ala Asp Asn Ala Val Ser Thr Ala 
1               5                   10                  15      


Ala Glu Pro Arg Arg Arg Pro Glu Pro Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Pro Ala Ala Pro Ala Arg Pro Arg Pro Cys Pro Ala Val Pro Ala Pro 
        35                  40                  45              


Ala Pro Gly Asp Thr His Phe Arg Thr Phe Arg Ser His Ala Asp Tyr 
    50                  55                  60                  


Arg Arg Ile Thr Arg Ala Ser Ala Leu Leu Asp Ala Cys Gly Phe Tyr 
65                  70                  75                  80  


Trp Gly Pro Leu Ser Val His Gly Ala His Glu Arg Leu Arg Ala Glu 
                85                  90                  95      


Pro Val Gly Thr Phe Leu Val Arg Asp Ser Arg Gln Arg Asn Cys Phe 
            100                 105                 110         


Phe Ala Leu Ser Val Lys Met Ala Ser Gly Pro Thr Ser Ile Arg Val 
        115                 120                 125             


His Phe Gln Ala Gly Arg Phe His Leu Asp Gly Ser Arg Glu Ser Phe 
    130                 135                 140                 


Asp Cys Leu Phe Glu Leu Leu Glu His Tyr Val Ala Ala Pro Arg Arg 
145                 150                 155                 160 


Met Leu Gly Ala Pro Leu Arg Gln Arg Arg Val Arg Pro Leu Gln Glu 
                165                 170                 175     


Leu Cys Arg Gln Arg Ile Val Ala Thr Val Gly Arg Glu Asn Leu Ala 
            180                 185                 190         


Arg Ile Pro Leu Asn Pro Val Leu Arg Asp Tyr Leu Ser Ser Phe Pro 
        195                 200                 205             


Phe Gln Ile 
    210     


<210>  7
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  8
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
1               5                   10                  15      


Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
            20                  25                  30          


Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
        35                  40                  45              


Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
    50                  55                  60                  


Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
65                  70                  75                  80  


Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                85                  90                  95      


Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
            100                 105                 110         


Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
        115                 120                 125             


Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
    130                 135                 140                 


Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
145                 150                 155                 160 


Asn Leu Pro Glu Arg 
                165 


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo IL-10

<400>  9
tgggggagaa cctgaagac                                                    19


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso IL-10

<400>  10
ccttgctctt gttttcacag g                                                 21


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo GADD45A

<400>  11
ttgcaatatg actttggagg aa                                                22


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso GADD45A

<400>  12
catcccccac cttatccat                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo GADD45B

<400>  13
cattgtctcc tggtcacga                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso GADD45B

<400>  14
taggggaccc actggttgt                                                    19


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo LSGAL1

<400>  15
agcgggaggc tgtctttc                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso LSGAL1

<400>  16
cctggtcgaa ggtgatgc                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo LSGAL3

<400>  17
gagcctaccc tgccactg                                                     18


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso LSGAL3

<400>  18
aggcaaaggc aggttataag g                                                 21


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo POLH

<400>  19
tgcatttact gtcatcaaga actgt                                             25


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso POLH

<400>  20
gcacagagga aaagcattgt g                                                 21


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo ICOSLG

<400>  21
gaccgatgcc tccaacac                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso ICOSLG

<400>  22
gagctccggt caaacgtg                                                     18


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo ETS2

<400>  23
cccctgtggc taacagttac a                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso ETS2

<400>  24
ggacccatca aaggtgtcaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo CCL7

<400>  25
gaaagcctct gcagcacttc                                                   20


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso CCL7

<400>  26
aatctgtagc agcaggtagt tgaa                                              24


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo IL1A

<400>  27
ggttgagttt aagccaatcc a                                                 21


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso IL1A

<400>  28
tgctgaccta ggcttgatga                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo CD163

<400>  29
ctggcgtgac atgttctgat                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso CD163

<400>  30
ggctgcctcc acctctaagt                                                   20


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo IFI27

<400>  31
ctcaggaact ctccttcttt gg                                                22


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso IFI27

<400>  32
tccgtggcct agagagtaag a                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo PLK2

<400>  33
agatctcgcg gattatcgtc                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso PLK2

<400>  34
tgtcaaatct gtcatctcgt aaca                                              24


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo FDXR

<400>  35
gtgacacagc cgtgattctg                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso FDXR

<400>  36
cttcgtgatg tccgttctct c                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo IL1B

<400>  37
ctgtcctgcg tgttgaaaga                                                   20


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso IL1B

<400>  38
ttgggtaatt tttgggatct aca                                               23


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo GDF15

<400>  39
ccggatactc acgccaga                                                     18


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso GDF15

<400>  40
agagatacgc aggtgcaggt                                                   20


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo THBS1

<400>  41
gccacagttc ctgatggag                                                    19


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso THBS1

<400>  42
ccatggagac cagccatc                                                     18


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo CXCL2

<400>  43
catcgaaaag atgctgaaaa atg                                               23


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso CXCL2

<400>  44
ttcaggaaca gccaccaata                                                   20


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo CXCR4

<400>  45
ctgtgagcag agggtccag                                                    19


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso CXCR4

<400>  46
atgaatgtcc acctcgcttt                                                   20


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo PCNA

<400>  47
tggagaactt ggaaatggaa a                                                 21


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso PCNA

<400>  48
gaactggttc attcatctct atgg                                              24


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo SOCS1

<400>  49
gccccttctg taggatggta                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso SOCS1

<400>  50
ctgctgtgga gactgcattg                                                   20


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo PTPRE

<400>  51
ggctcacctg gttcagga                                                     18


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso PTPRE

<400>  52
catcaccctt tgctgctctt                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo MITF

<400>  53
agggagctca cagagtctga a                                                 21


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso MITF

<400>  54
tgttaaatct tcttcttcgt tcaatc                                            26


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo CCR7

<400>  55
ggggaaacca atgaaaagc                                                    19


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso CCR7

<400>  56
acctcatctt gacacaggca ta                                                22


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo SLA

<400>  57
tgtcaccttg cgtcagaaga                                                   20


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso SLA

<400>  58
ggggtcctcc tgcagtct                                                     18


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador directo IL12A

<400>  59
cactcccaaa acctgctgag                                                   20


<210>  60
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador reverso IL12A

<400>  60
tctcttcaga agtgcaaggg ta                                                22


