                         SEQUENCE LISTING

<110>  ThromboGenics N.V.
 
<120>  Variants of plasminogen and plasmin

<130>  TG-039 PCT

<150>  EP09165237
<151>  2009-07-10

<150>  US61224514
<151>  2009-07-10

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 
1               5                   10                  15      


Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu Cys Ala Ala 
            20                  25                  30          


Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe Gln Tyr His 
        35                  40                  45              


Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys Ser Ser 
    50                  55                  60                  


Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met 
                85                  90                  95      


Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser 
            100                 105                 110         


Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu 
        115                 120                 125             


Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp 
    130                 135                 140                 


Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu 
145                 150                 155                 160 


Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr Asp Gly 
                165                 170                 175     


Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp Asp Ser 
            180                 185                 190         


Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro Asn Lys 
        195                 200                 205             


Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu Arg Pro 
    210                 215                 220                 


Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys Asp Ile 
225                 230                 235                 240 


Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr Tyr Gln Cys 
                245                 250                 255     


Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val Thr Val 
            260                 265                 270         


Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro His Thr His 
        275                 280                 285             


Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp Glu Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His Thr Thr Asn 
305                 310                 315                 320 


Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys Asp Ser Ser 
                325                 330                 335     


Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro Glu Leu Thr 
            340                 345                 350         


Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly 
        355                 360                 365             


Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser 
    370                 375                 380                 


Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala 
385                 390                 395                 400 


Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro 
                405                 410                 415     


Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu 
            420                 425                 430         


Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val 
        435                 440                 445             


Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe 
    450                 455                 460                 


Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly 
465                 470                 475                 480 


Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile 
                485                 490                 495     


Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys 
            500                 505                 510         


Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn 
        515                 520                 525             


Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro 
    530                 535                 540                 


Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly 
545                 550                 555                 560 


Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln 
                565                 570                 575     


Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu 
            580                 585                 590         


Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser 
        595                 600                 605             


Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val 
    610                 615                 620                 


Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu 
625                 630                 635                 640 


Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala 
                645                 650                 655     


Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr 
            660                 665                 670         


Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr 
        675                 680                 685             


Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val 
    690                 695                 700                 


Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val 
705                 710                 715                 720 


Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser 
                725                 730                 735     


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys 
            740                 745                 750         


Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro 
        755                 760                 765             


Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile 
    770                 775                 780                 


Glu Gly Val Met Arg Asn Asn 
785                 790     


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys 
1               5                   10                  15      


Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro 
            20                  25                  30          


Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly 
        35                  40                  45              


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu 
    50                  55                  60                  


Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln 
65                  70                  75                  80  


Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu 
                85                  90                  95      


Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            100                 105                 110         


Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro 
        115                 120                 125             


Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly 
    130                 135                 140                 


Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu 
145                 150                 155                 160 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly 
                165                 170                 175     


Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr 
            180                 185                 190         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        195                 200                 205             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    210                 215                 220                 


Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
225                 230                 235                 240 


Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 


<210>  3
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  artificial sequence encoding wild-type human microplasminogen - 
       sequence contains codons optimized for expression in Pichia

<400>  3
gcaccttcat tcgactgtgg taagcctcag gtcgaaccta agaagtgtcc aggtcgtgtt       60

gtcggtggct gtgtggctca tcctcattct tggccttggc aagtgtctct tagaactaga      120

tttggtatgc acttctgtgg tggcaccttg atctcacctg aatgggtctt aaccgcagct      180

cattgtctgg agaagtcacc acgtccatct tcatacaagg tcatccttgg cgcacatcag      240

gaagtcaatc ttgagcctca tgttcaggag atcgaagtct ctcgtttgtt cttggaacca      300

actcgtaaag acattgctct tctgaagctg tcatctcctg ccgtgattac cgacaaggta      360

attcctgcct gcttgcctag tcctaattac gtcgttgccg accgtaccga atgcttcatt      420

actggttggg gtgagactca aggtacgttc ggtgctggtc tgttgaaaga agcacaatta      480

cctgtgattg agaacaaggt ttgtaacaga tacgagttcc tgaatggtcg tgttcagtcc      540

actgagttgt gtgcaggtca ccttgcaggt ggtactgata gttgtcaagg tgattctggt      600

ggaccactgg tgtgcttcga gaaggataag tacatcttac aaggtgttac gtcttggggt      660

cttggatgtg ctcgtcctaa caagccaggt gtctacgtca gagtctccag attcgtaact      720

tggatcgaag gtgtcatgcg taacaactaa                                       750


<210>  4
<211>  768
<212>  DNA
<213>  artificial

<220>
<223>  artificial sequence encoding variant human microplasminogen with 
       K137Q mutation - sequence contains codons optimized for 
       expression in Pichia

<400>  4
ctcgagaaaa gagcaccttc attcgactgt ggtaagcctc aggtcgaacc taagaagtgt       60

ccaggtcgtg ttgtcggtgg ctgtgtggct catcctcatt cttggccttg gcaagtgtct      120

cttagaacta gatttggtat gcacttctgt ggtggcacct tgatctcacc tgaatgggtc      180

ttaaccgcag ctcattgtct ggagaagtca ccacgtccat cttcatacaa ggtcatcctt      240

ggcgcacatc aggaagtcaa tcttgagcct catgttcagg agatcgaagt ctctcgtttg      300

ttcttggaac caactcgtaa agacattgct cttctgaagc tgtcatctcc tgccgtgatt      360

accgacaagg taattcctgc ctgcttgcct agtcctaatt acgtcgttgc cgaccgtacc      420

gaatgcttca ttactggttg gggtgagact caaggtacgt tcggtgctgg tctgctgcag      480

gaagcacaat tacctgtgat tgagaacaag gtttgtaaca gatacgagtt cctgaatggt      540

cgtgttcagt ccactgagtt gtgtgcaggt caccttgcag gtggtactga tagttgtcaa      600

ggtgattctg gtggaccact ggtgtgcttc gagaaggata agtacatctt acaaggtgtt      660

acgtcttggg gtcttggatg tgctcgtcct aacaagccag gtgtctacgt cagagtctcc      720

agattcgtaa cttggatcga aggtgtcatg cgtaacaact aatctaga                   768


<210>  5
<211>  253
<212>  PRT
<213>  artificial

<220>
<223>  variant human microplasminogen with K137Q mutation and comprising
       N-terminal sequence LEKR of which KR is a KEX2 cleavage site

<400>  5

Leu Glu Lys Arg Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu 
1               5                   10                  15      


Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro 
            20                  25                  30          


His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His 
        35                  40                  45              


Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu 
                85                  90                  95      


Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu 
            100                 105                 110         


Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys 
        115                 120                 125             


Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile 
    130                 135                 140                 


Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Gln 
145                 150                 155                 160 


Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu 
                165                 170                 175     


Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu 
            180                 185                 190         


Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly 
    210                 215                 220                 


Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser 
225                 230                 235                 240 


Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 250             


<210>  6
<211>  768
<212>  DNA
<213>  artificial

<220>
<223>  artificial sequence encoding variant human microplasminogen with 
       K147H mutation - sequence contains codons optimized for 
       expression in Pichia

<400>  6
ctcgagaaaa gagcaccttc attcgactgt ggtaagcctc aggtcgaacc taagaagtgt       60

ccaggtcgtg ttgtcggtgg ctgtgtggct catcctcatt cttggccttg gcaagtgtct      120

cttagaacta gatttggtat gcacttctgt ggtggcacct tgatctcacc tgaatgggtc      180

ttaaccgcag ctcattgtct ggagaagtca ccacgtccat cttcatacaa ggtcatcctt      240

ggcgcacatc aggaagtcaa tcttgagcct catgttcagg agatcgaagt ctctcgtttg      300

ttcttggaac caactcgtaa agacattgct cttctgaagc tgtcatctcc tgccgtgatt      360

accgacaagg taattcctgc ctgcttgcct agtcctaatt acgtcgttgc cgaccgtacc      420

gaatgcttca ttactggttg gggtgagact caaggtacgt tcggtgctgg tctgttgaaa      480

gaagcacaat tacctgtgat tgagaaccac gtgtgtaaca gatacgagtt cctgaatggt      540

cgtgttcagt ccactgagtt gtgtgcaggt caccttgcag gtggtactga tagttgtcaa      600

ggtgattctg gtggaccact ggtgtgcttc gagaaggata agtacatctt acaaggtgtt      660

acgtcttggg gtcttggatg tgctcgtcct aacaagccag gtgtctacgt cagagtctcc      720

agattcgtaa cttggatcga aggtgtcatg cgtaacaact aatctaga                   768


<210>  7
<211>  253
<212>  PRT
<213>  artificial

<220>
<223>  variant human microplasminogen with K147H mutation and comprising
       N-terminal sequence LEKR of which KR is a KEX2 cleavage site

<400>  7

Leu Glu Lys Arg Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu 
1               5                   10                  15      


Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro 
            20                  25                  30          


His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His 
        35                  40                  45              


Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu 
                85                  90                  95      


Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu 
            100                 105                 110         


Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys 
        115                 120                 125             


Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile 
    130                 135                 140                 


Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys 
145                 150                 155                 160 


Glu Ala Gln Leu Pro Val Ile Glu Asn His Val Cys Asn Arg Tyr Glu 
                165                 170                 175     


Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu 
            180                 185                 190         


Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly 
    210                 215                 220                 


Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser 
225                 230                 235                 240 


Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 250             


<210>  8
<211>  768
<212>  DNA
<213>  artificial

<220>
<223>  artificial sequence encoding variant human microplasminogen with 
       R158H mutation - sequence contains codons optimized for 
       expression in Pichia

<400>  8
ctcgagaaaa gagcaccttc attcgactgt ggtaagcctc aggtcgaacc taagaagtgt       60

ccaggtcgtg ttgtcggtgg ctgtgtggct catcctcatt cttggccttg gcaagtgtct      120

cttagaacta gatttggtat gcacttctgt ggtggcacct tgatctcacc tgaatgggtc      180

ttaaccgcag ctcattgtct ggagaagtca ccacgtccat cttcatacaa ggtcatcctt      240

ggcgcacatc aggaagtcaa tcttgagcct catgttcagg agatcgaagt ctctcgtttg      300

ttcttggaac caactcgtaa agacattgct cttctgaagc tgtcatctcc tgccgtgatt      360

accgacaagg taattcctgc ctgcttgcct agtcctaatt acgtcgttgc cgaccgtacc      420

gaatgcttca ttactggttg gggtgagact caaggtacgt tcggtgctgg tctgttgaaa      480

gaagcacaat tacctgtgat tgagaacaag gtttgtaaca gatacgagtt cctgaatgga      540

cacgtgcagt ccactgagtt gtgtgcaggt caccttgcag gtggtactga tagttgtcaa      600

ggtgattctg gtggaccact ggtgtgcttc gagaaggata agtacatctt acaaggtgtt      660

acgtcttggg gtcttggatg tgctcgtcct aacaagccag gtgtctacgt cagagtctcc      720

agattcgtaa cttggatcga aggtgtcatg cgtaacaact aatctaga                   768


<210>  9
<211>  253
<212>  PRT
<213>  artificial

<220>
<223>  variant human microplasminogen with R158H mutation and comprising
       N-terminal sequence LEKR of which KR is a KEX2 cleavage site

<400>  9

Leu Glu Lys Arg Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu 
1               5                   10                  15      


Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro 
            20                  25                  30          


His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His 
        35                  40                  45              


Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu 
                85                  90                  95      


Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu 
            100                 105                 110         


Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys 
        115                 120                 125             


Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile 
    130                 135                 140                 


Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys 
145                 150                 155                 160 


Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu 
                165                 170                 175     


Phe Leu Asn Gly His Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu 
            180                 185                 190         


Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly 
    210                 215                 220                 


Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser 
225                 230                 235                 240 


Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 250             


<210>  10
<211>  768
<212>  DNA
<213>  artificial

<220>
<223>  artificial sequence encoding variant human microplasminogen with 
       K137Q, K147H and R158H mutations - sequence contains codons 
       optimized for expression in Pichia

<400>  10
ctcgagaaaa gagcaccttc attcgactgt ggtaagcctc aggtcgaacc taagaagtgt       60

ccaggtcgtg ttgtcggtgg ctgtgtggct catcctcatt cttggccttg gcaagtgtct      120

cttagaacta gatttggtat gcacttctgt ggtggcacct tgatctcacc tgaatgggtc      180

ttaaccgcag ctcattgtct ggagaagtca ccacgtccat cttcatacaa ggtcatcctt      240

ggcgcacatc aggaagtcaa tcttgagcct catgttcagg agatcgaagt ctctcgtttg      300

ttcttggaac caactcgtaa agacattgct cttctgaagc tgtcatctcc tgccgtgatt      360

accgacaagg taattcctgc ctgcttgcct agtcctaatt acgtcgttgc cgaccgtacc      420

gaatgcttca ttactggttg gggtgagact caaggtacgt tcggtgctgg tctgctgcag      480

gaagcacaat tacctgtgat tgagaaccac gtgtgtaaca gatacgagtt cctgaatgga      540

cacgtgcagt ccactgagtt gtgtgcaggt caccttgcag gtggtactga tagttgtcaa      600

ggtgattctg gtggaccact ggtgtgcttc gagaaggata agtacatctt acaaggtgtt      660

acgtcttggg gtcttggatg tgctcgtcct aacaagccag gtgtctacgt cagagtctcc      720

agattcgtaa cttggatcga aggtgtcatg cgtaacaact aatctaga                   768


<210>  11
<211>  253
<212>  PRT
<213>  artificial

<220>
<223>  variant human microplasminogen with K137Q, K147H and R158H 
       mutations and comprising N-terminal sequence LEKR of which KR is 
       a KEX2 cleavage site

<400>  11

Leu Glu Lys Arg Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu 
1               5                   10                  15      


Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro 
            20                  25                  30          


His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His 
        35                  40                  45              


Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu 
                85                  90                  95      


Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu 
            100                 105                 110         


Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys 
        115                 120                 125             


Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile 
    130                 135                 140                 


Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Gln 
145                 150                 155                 160 


Glu Ala Gln Leu Pro Val Ile Glu Asn His Val Cys Asn Arg Tyr Glu 
                165                 170                 175     


Phe Leu Asn Gly His Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu 
            180                 185                 190         


Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly 
    210                 215                 220                 


Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser 
225                 230                 235                 240 


Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 250             


<210>  12
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Lys137Gln mutation

<400>  12
cgttcggtgc tggtctgctg caggaagcac aattacctgt g                           41


<210>  13
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Lys137Gln mutation

<400>  13
cacaggtaat tgtgcttcct gcagcagacc agcaccgaac g                           41


<210>  14
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Lys137Arg mutation

<400>  14
ggtacgttcg gtgctggtct gttgcgtgaa gcacaattac ctgtgattg                   49


<210>  15
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Lys137Arg mutation

<400>  15
caatcacagg taattgtgct tcacgcaaca gaccagcacc gaacgtacc                   49


<210>  16
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Lys147Ala mutation

<400>  16
caattacctg tgattgagaa cgccgtgtgt aacagatacg agttc                       45


<210>  17
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Lys147Ala mutation

<400>  17
gaactcgtat ctgttacaca cggcgttctc aatcacaggt aattg                       45


<210>  18
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Lys147Glu mutation

<400>  18
caattacctg tgattgagaa cgaagtgtgt aacagatacg agttc                       45


<210>  19
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Lys147Glu mutation

<400>  19
gaactcgtat ctgttacaca cttcgttctc aatcacaggt aattg                       45


<210>  20
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Lys147Gln mutation

<400>  20
caattacctg tgattgagaa ccaagtgtgt aacagatacg agttc                       45


<210>  21
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Lys147Gln mutation

<400>  21
gaactcgtat ctgttacaca cttggttctc aatcacaggt aattg                       45


<210>  22
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Arg158Ala mutation

<400>  22
cagatacgag ttcctgaatg gcgccgtgca gtccactgag ttgtgtgcag g                51


<210>  23
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Arg158Ala mutation

<400>  23
cctgcacaca actcagtgga ctgcacggcg ccattcagga actcgtatct g                51


<210>  24
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  sense oligonucleotide Arg158Gln mutation

<400>  24
gatacgagtt cctgaatggt caggttcagt ccactgagtt gtgtg                       45


<210>  25
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  antisense oligonucleotide Arg158Gln mutation

<400>  25
cacacaactc agtggactga acctgaccat tcaggaactc gtatc                       45


<210>  26
<211>  812
<212>  PRT
<213>  Canis familiaris

<400>  26

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly His Gly Ser Leu Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Val Phe Ser Leu Thr Lys Lys Gln Leu Ser Val Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Glu Thr Gly Phe Ile Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Pro Glu Asn Ser 
65                  70                  75                  80  


Lys Ser Ser Ile Val Phe Arg Met Arg Asp Val Phe Leu Phe Glu Lys 
                85                  90                  95      


Arg Ile Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Thr Tyr Arg 
            100                 105                 110         


Gly Thr Met Ala Lys Thr Lys Asn Asp Val Ala Cys Gln Lys Trp Ser 
        115                 120                 125             


Asp Asn Ser Pro His Lys Pro Asn Tyr Thr Pro Glu Lys His Pro Leu 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Asn 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asn Pro Asp Val Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asn Ile Pro Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Lys Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asn Ser Gln Thr Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Ser Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Met Asp Pro Asn Lys Arg Trp Glu Phe 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Pro Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Ser Tyr Arg Gly Lys Val Ser 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Glu Gln Thr Pro 
    290                 295                 300                 


His Lys His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asn Ser Glu Val Arg Trp Glu His Cys Gln Ile Pro Ser Cys 
            340                 345                 350         


Glu Ser Ser Pro Ile Thr Thr Glu Tyr Leu Asp Ala Pro Ala Ser Val 
        355                 360                 365             


Pro Pro Glu Gln Thr Pro Val Val Gln Glu Cys Tyr His Gly Asn Gly 
    370                 375                 380                 


Gln Ser Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Arg Lys Cys 
385                 390                 395                 400 


Gln Ser Trp Ser Ser Met Thr Pro His Arg His Glu Lys Thr Pro Glu 
                405                 410                 415     


His Phe Pro Glu Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp 
            420                 425                 430         


Ala Asp Lys Ser Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp 
        435                 440                 445             


Glu Phe Cys Asn Leu Arg Lys Cys Leu Asp Pro Glu Ala Ser Ala Thr 
    450                 455                 460                 


Asn Ser Pro Ala Val Pro Gln Val Pro Ser Gly Gln Glu Pro Ser Ala 
465                 470                 475                 480 


Ser Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Lys Ala 
                485                 490                 495     


Thr Thr Val Met Gly Ile Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro 
            500                 505                 510         


His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Gln Ala Gly Leu 
        515                 520                 525             


Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Asn Gly Pro Trp 
    530                 535                 540                 


Cys Tyr Thr Met Asn Gln Arg Lys Leu Phe Asp Tyr Cys Asp Val Pro 
545                 550                 555                 560 


Gln Cys Val Ser Thr Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro 
                565                 570                 575     


Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Pro His 
            580                 585                 590         


Ser Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg Tyr Gly Lys His Phe 
        595                 600                 605             


Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His 
    610                 615                 620                 


Cys Leu Glu Arg Ser Ser Arg Pro Ala Ser Tyr Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ala His Lys Glu Val Asn Leu Glu Ser Asp Val Gln Glu Ile Glu Val 
                645                 650                 655     


Tyr Lys Leu Phe Leu Glu Pro Thr Arg Ala Asp Ile Ala Leu Leu Lys 
            660                 665                 670         


Leu Ser Ser Pro Ala Val Ile Thr Ser Lys Val Ile Pro Ala Cys Leu 
        675                 680                 685             


Pro Pro Pro Asn Tyr Val Val Ala Asp Arg Thr Leu Cys Tyr Ile Thr 
    690                 695                 700                 


Gly Trp Gly Glu Thr Gln Gly Thr Tyr Gly Ala Gly Leu Leu Lys Glu 
705                 710                 715                 720 


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Tyr 
                725                 730                 735     


Leu Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly Asn Leu Ala 
            740                 745                 750         


Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
    770                 775                 780                 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
785                 790                 795                 800 


Phe Val Thr Trp Ile Glu Gly Ile Met Arg Asn Asn 
                805                 810         


<210>  27
<211>  810
<212>  PRT
<213>  Pan troglodytes

<400>  27

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Leu Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Gln Leu Pro Asn Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ser Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Leu Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Lys Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Thr Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Ile Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Asn Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  28
<211>  815
<212>  PRT
<213>  Pan troglodytes

<400>  28

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Leu Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Gln Leu Pro Asn Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ser Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Ser Ser Asn Ile Ala Gly Lys Tyr 
        595                 600                 605             


Trp His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr 
    610                 615                 620                 


Ala Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val 
625                 630                 635                 640 


Ile Leu Gly Ala His Gln Glu Val Lys Leu Glu Pro His Val Gln Glu 
                645                 650                 655     


Ile Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Thr Asp Ile Ala 
            660                 665                 670         


Leu Leu Lys Leu Ser Ser Pro Ala Ile Ile Thr Asp Lys Val Ile Pro 
        675                 680                 685             


Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys 
    690                 695                 700                 


Phe Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu 
705                 710                 715                 720 


Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg 
                725                 730                 735     


Asn Glu Phe Leu Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly 
            740                 745                 750         


His Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        755                 760                 765             


Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser 
    770                 775                 780                 


Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg 
785                 790                 795                 800 


Val Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810                 815 


<210>  29
<211>  800
<212>  PRT
<213>  Pan troglodytes

<400>  29

Met Leu Met Asp Tyr Glu Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val 
1               5                   10                  15      


Asn Thr Gln Gly Ala Ser Leu Phe Ser Val Thr Lys Lys Gln Leu Gly 
            20                  25                  30          


Ala Gly Ser Ile Glu Glu Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu 
        35                  40                  45              


Phe Thr Cys Arg Ala Phe Gln Tyr His Ser Lys Glu Gln Gln Cys Val 
    50                  55                  60                  


Ile Met Ala Glu Asn Arg Lys Ser Ser Ile Ile Ile Arg Met Arg Asp 
65                  70                  75                  80  


Val Val Leu Phe Glu Lys Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly 
                85                  90                  95      


Asn Gly Lys Asn Tyr Arg Gly Thr Met Ser Lys Thr Lys Asn Gly Ile 
            100                 105                 110         


Thr Cys Gln Lys Trp Ser Ser Thr Ser Pro His Arg Pro Arg Phe Ser 
        115                 120                 125             


Pro Ala Thr His Pro Ser Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn 
    130                 135                 140                 


Pro Asp Asn Asp Pro Gln Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu 
145                 150                 155                 160 


Lys Arg Tyr Asp Tyr Cys Asp Ile Leu Glu Cys Glu Glu Glu Cys Met 
                165                 170                 175     


His Cys Ser Gly Glu Asn Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser 
            180                 185                 190         


Gly Leu Glu Cys Gln Ala Trp Asp Ser Gln Ser Pro His Ala His Gly 
        195                 200                 205             


Tyr Ile Pro Ser Lys Phe Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys 
    210                 215                 220                 


Arg Asn Pro Asp Gly Glu Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro 
225                 230                 235                 240 


Asn Lys Arg Trp Glu Leu Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro 
                245                 250                 255     


Pro Ser Ser Gly Pro Thr Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn 
            260                 265                 270         


Tyr Arg Gly Asn Val Ala Val Thr Val Ser Gly His Thr Cys Gln His 
        275                 280                 285             


Trp Ser Ala Gln Thr Pro His Thr His Asn Arg Thr Pro Glu Asn Phe 
    290                 295                 300                 


Pro Cys Lys Asn Leu Asp Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys 
305                 310                 315                 320 


Arg Ala Pro Trp Cys His Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr 
                325                 330                 335     


Cys Lys Ile Pro Ser Cys Asp Ser Ser Leu Val Ser Thr Glu Gln Leu 
            340                 345                 350         


Ala Pro Thr Ala Pro Pro Glu Leu Thr Pro Val Val Gln Asp Cys Tyr 
        355                 360                 365             


His Gly Asp Gly Gln Ser Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr 
    370                 375                 380                 


Gly Lys Lys Cys Gln Ser Trp Ser Ser Met Thr Pro His Arg His Gln 
385                 390                 395                 400 


Lys Thr Pro Glu Asn Tyr Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys 
                405                 410                 415     


Arg Asn Pro Asp Ala Asp Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro 
            420                 425                 430         


Ser Val Arg Trp Glu Tyr Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu 
        435                 440                 445             


Ala Ser Val Val Ala Pro Pro Pro Val Val Gln Leu Pro Asn Val Glu 
    450                 455                 460                 


Thr Pro Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg 
465                 470                 475                 480 


Gly Lys Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala 
                485                 490                 495     


Ala Gln Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro 
            500                 505                 510         


Arg Ala Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val 
        515                 520                 525             


Gly Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr 
    530                 535                 540                 


Cys Asp Val Pro Gln Cys Ala Ser Pro Ser Phe Asp Cys Gly Lys Pro 
545                 550                 555                 560 


Gln Val Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val 
                565                 570                 575     


Ala His Pro His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Leu 
            580                 585                 590         


Gly Met His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu 
        595                 600                 605             


Thr Ala Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys 
    610                 615                 620                 


Val Ile Leu Gly Ala His Gln Glu Val Lys Leu Glu Pro His Val Gln 
625                 630                 635                 640 


Glu Ile Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Thr Asp Ile 
                645                 650                 655     


Ala Leu Leu Lys Leu Ser Ser Pro Ala Ile Ile Thr Asp Lys Val Ile 
            660                 665                 670         


Pro Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu 
        675                 680                 685             


Cys Phe Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly 
    690                 695                 700                 


Leu Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn 
705                 710                 715                 720 


Arg Asn Glu Phe Leu Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala 
                725                 730                 735     


Gly His Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly 
            740                 745                 750         


Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr 
        755                 760                 765             


Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val 
    770                 775                 780                 


Arg Val Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
785                 790                 795                 800 


<210>  30
<211>  810
<212>  PRT
<213>  Macaca mulatta

<400>  30

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Lys Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Ile Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Glu Glu Glu Phe Thr Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Val Phe Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Arg Thr Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Thr Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Gly Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Glu Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Asp Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asp Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys His Gly Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Lys Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Glu Ser Ser Pro Val Ser Thr Glu Pro Leu Asp Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Glu Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Trp His Glu Lys Thr Pro Glu Asn Phe 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Gly Ser Val Ala Ala Pro 
    450                 455                 460                 


Pro Pro Val Ala Gln Leu Pro Asp Ala Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Lys Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Ser 
            500                 505                 510         


His Arg Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Phe Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Ser Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Tyr Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Ile Ser Leu Arg Thr Arg Leu Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Ser Arg Pro Ser Phe Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Arg Glu Val His Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Lys 
                645                 650                 655     


Met Phe Ser Glu Pro Ala Arg Ala Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Ile Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Tyr Gly Ala Gly Leu Leu Lys Glu Ala Arg 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Thr Val Lys Thr Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  31
<211>  810
<212>  PRT
<213>  Pongo abelii

<400>  31

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Arg Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Glu Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Ala Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu His Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Glu Ala Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln Arg Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


Gln Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Lys Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Gly Ser Ser Pro Val Ser Thr Glu Gln Leu Asp Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Trp His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asp Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Gly Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Gln Leu Pro Asn Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Gln Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Glu Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys His Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ser Ser Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Ala His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Thr His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Ala Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Gly Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  32
<211>  809
<212>  PRT
<213>  Sus scrofa

<400>  32

Met Asp His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Leu Gly Asp Ser Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Phe 
            20                  25                  30          


Leu Phe Ser Leu Ser Arg Lys Gln Val Ala Ala Arg Ser Val Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Ala Glu Thr Asn Phe Ile Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Asp Gln Gln Cys Val Val Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Thr Ser Pro Ile Ala Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Arg Ile Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Thr Ser Lys Thr Lys Ser Gly Val Ile Cys Gln Lys Trp Ser 
        115                 120                 125             


Val Ser Ser Pro His Ile Pro Lys Tyr Ser Pro Glu Lys Phe Pro Leu 
    130                 135                 140                 


Ala Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Lys 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Thr Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Asp Glu Cys Met His Cys Ser Gly Glu His 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Met Ser Gly Ile Glu Cys Gln Ser 
        195                 200                 205             


Trp Gly Ser Gln Ser Pro His Ala His Gly Tyr Leu Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Phe 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Thr Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Asn Tyr Arg Gly Thr Val Ser 
        275                 280                 285             


Val Thr Ala Ser Gly His Thr Cys Gln Arg Trp Ser Ala Gln Ser Pro 
    290                 295                 300                 


His Lys His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Glu 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asp Ser Glu Val Arg Trp Asp Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Gly Ser Ser Thr Thr Ser Thr Glu Tyr Leu Asp Ala Pro Val Pro Pro 
        355                 360                 365             


Glu Gln Thr Pro Val Ala Gln Asp Cys Tyr Arg Gly Asn Gly Glu Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Arg Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Val Ser Met Thr Pro His Arg His Glu Lys Thr Pro Gly Asn Phe 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Ser Pro Trp Cys Tyr Thr Thr Asp Pro Arg Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Glu Thr Glu Gln Gln Val Thr Asn Phe 
    450                 455                 460                 


Pro Ala Ile Ala Gln Val Pro Ser Val Glu Asp Leu Ser Glu Asp Cys 
465                 470                 475                 480 


Met Phe Gly Asn Gly Lys Arg Tyr Arg Gly Lys Arg Ala Thr Thr Val 
                485                 490                 495     


Ala Gly Val Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Arg His 
            500                 505                 510         


Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn 
        515                 520                 525             


Tyr Cys Arg Asn Pro Asp Gly Asp Asp Asn Gly Pro Trp Cys Tyr Thr 
    530                 535                 540                 


Thr Asn Pro Gln Lys Leu Phe Asp Tyr Cys Asp Val Pro Gln Cys Val 
545                 550                 555                 560 


Thr Ser Ser Phe Asp Cys Gly Lys Pro Lys Val Glu Pro Lys Lys Cys 
                565                 570                 575     


Pro Ala Arg Val Val Gly Gly Cys Val Ser Ile Pro His Ser Trp Pro 
            580                 585                 590         


Trp Gln Ile Ser Leu Arg His Arg Tyr Gly Gly His Phe Cys Gly Gly 
        595                 600                 605             


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Lys His Cys Leu Glu 
    610                 615                 620                 


Lys Ser Ser Ser Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Glu 
625                 630                 635                 640 


Glu Tyr His Leu Gly Glu Gly Val Gln Glu Ile Asp Val Ser Lys Leu 
                645                 650                 655     


Phe Lys Glu Pro Ser Glu Ala Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            660                 665                 670         


Pro Ala Ile Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Thr Pro 
        675                 680                 685             


Asn Tyr Val Val Ala Asp Arg Thr Ala Cys Tyr Ile Thr Gly Trp Gly 
    690                 695                 700                 


Glu Thr Lys Gly Thr Tyr Gly Ala Gly Leu Leu Lys Glu Ala Arg Leu 
705                 710                 715                 720 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Tyr Leu Gly Gly 
                725                 730                 735     


Lys Val Ser Pro Asn Glu Leu Cys Ala Gly His Leu Ala Gly Gly Ile 
            740                 745                 750         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        755                 760                 765             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    770                 775                 780                 


Leu Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
785                 790                 795                 800 


Trp Ile Glu Glu Ile Met Arg Arg Asn 
                805                 


<210>  33
<211>  812
<212>  PRT
<213>  Bos Taurus

<400>  33

Met Leu Pro Ala Ser Pro Lys Met Glu His Lys Ala Val Val Phe Leu 
1               5                   10                  15      


Ile Leu Leu Phe Leu Lys Ser Gly Leu Gly Asp Leu Leu Asp Asp Tyr 
            20                  25                  30          


Val Asn Thr Gln Gly Ala Ser Leu Leu Ser Leu Ser Arg Lys Asn Leu 
        35                  40                  45              


Ala Gly Arg Ser Val Glu Asp Cys Ala Ala Lys Cys Glu Glu Glu Thr 
    50                  55                  60                  


Asp Phe Val Cys Arg Ala Phe Gln Tyr His Ser Lys Glu Gln Gln Cys 
65                  70                  75                  80  


Val Val Met Ala Glu Asn Ser Lys Asn Thr Pro Val Phe Arg Met Arg 
                85                  90                  95      


Asp Val Ile Leu Tyr Glu Lys Arg Ile Tyr Leu Leu Glu Cys Lys Thr 
            100                 105                 110         


Gly Asn Gly Gln Thr Tyr Arg Gly Thr Thr Ala Glu Thr Lys Ser Gly 
        115                 120                 125             


Val Thr Cys Gln Lys Trp Ser Ala Thr Ser Pro His Val Pro Lys Phe 
    130                 135                 140                 


Ser Pro Glu Lys Phe Pro Leu Ala Gly Leu Glu Glu Asn Tyr Cys Arg 
145                 150                 155                 160 


Asn Pro Asp Asn Asp Glu Asn Gly Pro Trp Cys Tyr Thr Thr Asp Pro 
                165                 170                 175     


Asp Lys Arg Tyr Asp Tyr Cys Asp Ile Pro Glu Cys Glu Asp Lys Cys 
            180                 185                 190         


Met His Cys Ser Gly Glu Asn Tyr Glu Gly Lys Ile Ala Lys Thr Met 
        195                 200                 205             


Ser Gly Arg Asp Cys Gln Ala Trp Asp Ser Gln Ser Pro His Ala His 
    210                 215                 220                 


Gly Tyr Ile Pro Ser Lys Phe Pro Ser Lys Asn Leu Lys Met Asn Tyr 
225                 230                 235                 240 


Cys Arg Asn Pro Asp Gly Glu Pro Arg Pro Trp Cys Phe Thr Thr Asp 
                245                 250                 255     


Pro Gln Lys Arg Trp Glu Phe Cys Asp Ile Pro Arg Cys Thr Thr Pro 
            260                 265                 270         


Pro Pro Ser Ser Gly Pro Lys Tyr Gln Cys Leu Lys Gly Thr Gly Lys 
        275                 280                 285             


Asn Tyr Gly Gly Thr Val Ala Val Thr Glu Ser Gly His Thr Cys Gln 
    290                 295                 300                 


Arg Trp Ser Glu Gln Thr Pro His Lys His Asn Arg Thr Pro Glu Asn 
305                 310                 315                 320 


Phe Pro Cys Lys Asn Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asn Gly 
                325                 330                 335     


Glu Lys Ala Pro Trp Cys Tyr Thr Thr Asn Ser Lys Val Arg Trp Glu 
            340                 345                 350         


Tyr Cys Thr Ile Pro Ser Cys Glu Ser Ser Pro Leu Ser Thr Glu Arg 
        355                 360                 365             


Met Asp Val Pro Val Pro Pro Glu Gln Thr Pro Val Pro Gln Asp Cys 
    370                 375                 380                 


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Ser Ser Thr Thr Ile 
385                 390                 395                 400 


Thr Gly Arg Lys Cys Gln Ser Trp Ser Ser Met Thr Pro His Arg His 
                405                 410                 415     


Leu Lys Thr Pro Glu Asn Tyr Pro Asn Ala Gly Leu Thr Met Asn Tyr 
            420                 425                 430         


Cys Arg Asn Pro Asp Ala Asp Lys Ser Pro Trp Cys Tyr Thr Thr Asp 
        435                 440                 445             


Pro Arg Val Arg Trp Glu Phe Cys Asn Leu Lys Lys Cys Ser Glu Thr 
    450                 455                 460                 


Pro Glu Gln Val Pro Ala Ala Pro Gln Ala Pro Gly Val Glu Asn Pro 
465                 470                 475                 480 


Pro Glu Ala Asp Cys Met Ile Gly Met Gly Lys Ser Tyr Arg Gly Lys 
                485                 490                 495     


Lys Ala Thr Thr Val Ala Gly Val Pro Cys Gln Glu Trp Ala Ala Gln 
            500                 505                 510         


Glu Pro His His His Ser Ile Phe Thr Pro Glu Thr Asn Pro Gln Ser 
        515                 520                 525             


Gly Leu Glu Arg Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Asn Gly 
    530                 535                 540                 


Pro Trp Cys Tyr Thr Met Asn Pro Arg Lys Leu Phe Asp Tyr Cys Asp 
545                 550                 555                 560 


Val Pro Gln Cys Glu Ser Ser Phe Asp Cys Gly Lys Pro Lys Val Glu 
                565                 570                 575     


Pro Lys Lys Cys Ser Gly Arg Ile Val Gly Gly Cys Val Ser Lys Pro 
            580                 585                 590         


His Ser Trp Pro Trp Gln Val Ser Leu Arg Arg Ser Ser Arg His Phe 
        595                 600                 605             


Cys Gly Gly Thr Leu Ile Ser Pro Lys Trp Val Leu Thr Ala Ala His 
    610                 615                 620                 


Cys Leu Asp Asn Ile Leu Ala Leu Ser Phe Tyr Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ala His Asn Glu Lys Val Arg Glu Gln Ser Val Gln Glu Ile Pro Val 
                645                 650                 655     


Ser Arg Leu Phe Arg Glu Pro Ser Gln Ala Asp Ile Ala Leu Leu Lys 
            660                 665                 670         


Leu Ser Arg Pro Ala Ile Ile Thr Lys Glu Val Ile Pro Ala Cys Leu 
        675                 680                 685             


Pro Pro Pro Asn Tyr Met Val Ala Ala Arg Thr Glu Cys Tyr Ile Thr 
    690                 695                 700                 


Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Glu Gly Leu Leu Lys Glu 
705                 710                 715                 720 


Ala His Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Asn Glu Tyr 
                725                 730                 735     


Leu Asp Gly Arg Val Lys Pro Thr Glu Leu Cys Ala Gly His Leu Ile 
            740                 745                 750         


Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
    770                 775                 780                 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Pro 
785                 790                 795                 800 


Tyr Val Pro Trp Ile Glu Glu Thr Met Arg Arg Asn 
                805                 810         


<210>  34
<211>  811
<212>  PRT
<213>  Equus caballus

<400>  34

Met Glu His Gln Glu Val Val Phe Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly His Gly Asp Ile Leu Asp Asp Tyr Val Thr Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Thr Phe Thr Arg Lys Pro Leu Ser Ala Ser Ser Ile Glu Glu 
        35                  40                  45              


Cys Glu Ala Lys Cys Thr Glu Glu Thr Ala Phe Ile Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Pro Arg Cys Val Leu Leu Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Pro Val Met Arg Met Arg Asp Val Ile Leu Phe Glu Lys 
                85                  90                  95      


Arg Ile Tyr Leu Ser Glu Cys Lys Thr Gly Thr Gly Arg Ser Tyr Arg 
            100                 105                 110         


Gly Thr Thr Ser Lys Thr Lys Asn Gly Val Ser Cys Gln Lys Trp Ser 
        115                 120                 125             


Asp Thr Ser Pro His Ile Pro Lys Tyr Ser Pro Asp Lys Asn Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Lys 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Gly Thr Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Asp Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Ile Ser Gly Leu Glu Cys Gln Pro 
        195                 200                 205             


Trp Ala Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Arg Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Met Asp Pro Asp Lys Arg Trp Glu Phe 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Ser Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Asn Tyr Arg Gly Arg Val Ser 
        275                 280                 285             


Val Thr Gln Ser Gly Leu Thr Cys Gln Arg Trp Ser Glu Gln Thr Pro 
    290                 295                 300                 


His Lys His Asn Arg Thr Pro Asp Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Ser Ser Glu Thr Arg Trp Glu Tyr Cys Asn Ile Pro Ser Cys 
            340                 345                 350         


Thr Ser Ser Ser Val Pro Thr Glu Ile Thr Asp Ala Ser Glu Pro Pro 
        355                 360                 365             


Glu Gln Thr Pro Val Val Gln Asp Cys Tyr Gln Asp Lys Gly Glu Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Ile Thr Val Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Trp His Gln Lys Thr Pro Glu Lys Tyr 
                405                 410                 415     


Pro Asn Ala Asp Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Gly Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp Glu Phe 
        435                 440                 445             


Cys Asn Leu Arg Arg Cys Ser Glu Thr Gln Gln Ser Phe Ser Asn Ser 
    450                 455                 460                 


Ser Pro Thr Asp Thr Gln Val Pro Ser Val Gln Glu Pro Ser Glu Pro 
465                 470                 475                 480 


Asp Cys Met Leu Gly Ile Gly Lys Gly Tyr Gln Gly Lys Lys Ala Thr 
                485                 490                 495     


Thr Val Thr Gly Thr Arg Cys Gln Ala Trp Ala Ala Gln Glu Pro His 
            500                 505                 510         


Arg His Ser Ile Phe Thr Pro Glu Ala Asn Pro Trp Ala Asn Leu Glu 
        515                 520                 525             


Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Asn Gly Pro Trp Cys 
    530                 535                 540                 


Tyr Thr Met Asn Pro Gln Lys Leu Phe Asp Tyr Cys Asp Val Pro Gln 
545                 550                 555                 560 


Cys Glu Ser Ser Pro Phe Asp Cys Gly Lys Pro Lys Val Glu Pro Lys 
                565                 570                 575     


Lys Cys Ser Gly Arg Ile Val Gly Gly Cys Val Ala Ile Ala His Ser 
            580                 585                 590         


Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg Phe Gly Arg His Phe Cys 
        595                 600                 605             


Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys 
    610                 615                 620                 


Leu Glu Arg Ser Ser Arg Pro Ser Thr Tyr Lys Val Val Leu Gly Thr 
625                 630                 635                 640 


His His Glu Leu Arg Leu Ala Ala Gly Ala Gln Gln Ile Asp Val Ser 
                645                 650                 655     


Lys Leu Phe Leu Glu Pro Ser Arg Ala Asp Ile Ala Leu Leu Lys Leu 
            660                 665                 670         


Ser Ser Pro Ala Ile Ile Thr Gln Asn Val Ile Pro Ala Cys Leu Pro 
        675                 680                 685             


Pro Ala Asp Tyr Val Val Ala Asn Trp Ala Glu Cys Phe Val Thr Gly 
    690                 695                 700                 


Trp Gly Glu Thr Gln Asp Ser Ser Asn Ala Gly Val Leu Lys Glu Ala 
705                 710                 715                 720 


Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Tyr Leu 
                725                 730                 735     


Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His Leu Val Gly 
            740                 745                 750         


Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe 
        755                 760                 765             


Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly 
    770                 775                 780                 


Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Ser Phe 
785                 790                 795                 800 


Ile Asn Trp Ile Glu Arg Ile Met Gln Ser Asn 
                805                 810     


<210>  35
<211>  812
<212>  PRT
<213>  Mus musculus

<400>  35

Met Asp His Lys Glu Val Ile Leu Leu Phe Leu Leu Leu Leu Lys Pro 
1               5                   10                  15      


Gly Gln Gly Asp Ser Leu Asp Gly Tyr Ile Ser Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Leu Thr Lys Lys Gln Leu Ala Ala Gly Gly Val Ala Asp 
        35                  40                  45              


Cys Leu Ala Lys Cys Glu Gly Glu Thr Asp Phe Val Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Thr Ser Ser Ile Ile Arg Met Arg Asp Val Ile Leu Phe Glu Lys 
                85                  90                  95      


Arg Val Tyr Leu Ser Glu Cys Lys Thr Gly Ile Gly Asn Ser Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Arg Thr Lys Ser Gly Val Ala Cys Gln Lys Trp Gly 
        115                 120                 125             


Ala Thr Phe Pro His Val Pro Asn Tyr Ser Pro Ser Thr His Pro Asn 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Asp Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asn Ile Pro Glu Cys Glu Glu Glu Cys Met Tyr Cys Ser Gly Glu Lys 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Asp Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ala Lys Phe 
    210                 215                 220                 


Pro Ser Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Thr Lys Arg Trp Glu Tyr 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Pro Pro Ser Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Asn Tyr Arg Gly Thr Val Ser 
        275                 280                 285             


Val Thr Val Ser Gly Lys Thr Cys Gln Arg Trp Ser Glu Gln Thr Pro 
    290                 295                 300                 


His Arg His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Glu 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asp Ser Gln Leu Arg Trp Glu Tyr Cys Glu Ile Pro Ser Cys 
            340                 345                 350         


Glu Ser Ser Ala Ser Pro Asp Gln Ser Asp Ser Ser Val Pro Pro Glu 
        355                 360                 365             


Glu Gln Thr Pro Val Val Gln Glu Cys Tyr Gln Ser Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ala Ala Met Phe Pro His Arg His Ser Lys Thr Pro Glu Asn Phe 
                405                 410                 415     


Pro Asp Ala Gly Leu Glu Met Asn Tyr Cys Arg Asn Pro Asp Gly Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Arg Cys Ser Glu Thr Gly Gly Ser Val Val Glu Leu 
    450                 455                 460                 


Pro Thr Val Ser Gln Glu Pro Ser Gly Pro Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Cys Met Tyr Gly Asn Gly Lys Asp Tyr Arg Gly Lys Thr Ala Val Thr 
                485                 490                 495     


Ala Ala Gly Thr Pro Cys Gln Gly Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Gln Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Asn Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Ile Pro Leu Cys 
545                 550                 555                 560 


Ala Ser Ala Ser Ser Phe Glu Cys Gly Lys Pro Gln Val Glu Pro Lys 
                565                 570                 575     


Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Pro His Ser 
            580                 585                 590         


Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg Phe Thr Gly Gln His Phe 
        595                 600                 605             


Cys Gly Gly Thr Leu Ile Ala Pro Glu Trp Val Leu Thr Ala Ala His 
    610                 615                 620                 


Cys Leu Glu Lys Ser Ser Arg Pro Glu Phe Tyr Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ala His Glu Glu Tyr Ile Arg Gly Ser Asp Val Gln Glu Ile Ser Val 
                645                 650                 655     


Ala Lys Leu Ile Leu Glu Pro Asn Asn Arg Asp Ile Ala Leu Leu Lys 
            660                 665                 670         


Leu Ser Arg Pro Ala Thr Ile Thr Asp Lys Val Ile Pro Ala Cys Leu 
        675                 680                 685             


Pro Ser Pro Asn Tyr Met Val Ala Asp Arg Thr Ile Cys Tyr Ile Thr 
    690                 695                 700                 


Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Arg Leu Lys Glu 
705                 710                 715                 720 


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Val Glu Tyr 
                725                 730                 735     


Leu Asn Asn Arg Val Lys Ser Thr Glu Leu Cys Ala Gly Gln Leu Ala 
            740                 745                 750         


Gly Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
    770                 775                 780                 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
785                 790                 795                 800 


Phe Val Asp Trp Ile Glu Arg Glu Met Arg Asn Asn 
                805                 810         


<210>  36
<211>  812
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Met Asp His Lys Glu Ile Ile Leu Leu Phe Leu Leu Phe Leu Lys Pro 
1               5                   10                  15      


Gly Gln Gly Asp Ser Leu Asp Gly Tyr Val Ser Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu His Ser Leu Thr Lys Lys Gln Leu Ala Ala Gly Ser Ile Ala Asp 
        35                  40                  45              


Cys Leu Ala Lys Cys Glu Gly Glu Thr Asp Phe Ile Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Thr Ser Ser Ile Ile Arg Met Arg Asp Val Ile Leu Phe Glu Lys 
                85                  90                  95      


Arg Val Tyr Leu Ser Glu Cys Lys Thr Gly Ile Gly Lys Gly Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Thr Gly Val Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Asp Thr Ser Pro His Val Pro Lys Tyr Ser Pro Ser Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Asp Gln Arg Tyr Glu Tyr Cys 
                165                 170                 175     


Asn Ile Pro Glu Cys Glu Glu Glu Cys Met Tyr Cys Ser Gly Glu Lys 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Asp Cys Gln Ser 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ala Lys Phe 
    210                 215                 220                 


Pro Ser Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Tyr 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Pro Pro Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Asn Tyr Arg Gly Thr Val Ser 
        275                 280                 285             


Val Thr Ala Ser Gly Lys Thr Cys Gln Arg Trp Ser Glu Gln Thr Pro 
    290                 295                 300                 


His Arg His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Glu 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asp Ser Gln Leu Arg Trp Glu Tyr Cys Glu Ile Pro Ser Cys 
            340                 345                 350         


Gly Ser Ser Val Ser Pro Asp Gln Ser Asp Ser Ser Val Leu Pro Glu 
        355                 360                 365             


Gln Thr Pro Val Val Gln Glu Cys Tyr Gln Gly Asn Gly Lys Ser Tyr 
    370                 375                 380                 


Arg Gly Thr Ser Ser Thr Thr Asn Thr Gly Lys Lys Cys Gln Ser Trp 
385                 390                 395                 400 


Val Ser Met Thr Pro His Ser His Ser Lys Thr Pro Ala Asn Phe Pro 
                405                 410                 415     


Asp Ala Gly Leu Glu Met Asn Tyr Cys Arg Asn Pro Asp Asn Asp Gln 
            420                 425                 430         


Arg Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Arg Cys Ser Glu Thr Gly Gly Gly Val Ala Glu Ser 
    450                 455                 460                 


Ala Ile Val Pro Gln Val Pro Ser Ala Pro Gly Thr Ser Glu Thr Asp 
465                 470                 475                 480 


Cys Met Tyr Gly Asn Gly Lys Glu Tyr Arg Gly Lys Thr Ala Val Thr 
                485                 490                 495     


Ala Ala Gly Thr Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Ser 
            500                 505                 510         


His Arg Ile Phe Thr Pro Gln Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Asn Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Met Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asn Ile Pro Leu Cys 
545                 550                 555                 560 


Ala Ser Leu Ser Ser Phe Glu Cys Gly Lys Pro Gln Val Glu Pro Lys 
                565                 570                 575     


Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Pro His Ser 
            580                 585                 590         


Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg Phe Ser Gly Gln His Phe 
        595                 600                 605             


Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His 
    610                 615                 620                 


Cys Leu Glu Lys Ser Ser Arg Pro Glu Phe Tyr Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ala His Glu Glu Arg Ile Leu Gly Ser Asp Val Gln Gln Ile Ala Val 
                645                 650                 655     


Thr Lys Leu Val Leu Glu Pro Asn Asp Ala Asp Ile Ala Leu Leu Lys 
            660                 665                 670         


Leu Ser Arg Pro Ala Thr Ile Thr Asp Asn Val Ile Pro Ala Cys Leu 
        675                 680                 685             


Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Leu Cys Tyr Ile Thr 
    690                 695                 700                 


Gly Trp Gly Glu Thr Lys Gly Thr Pro Gly Ala Gly Arg Leu Lys Glu 
705                 710                 715                 720 


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Ala Glu Tyr 
                725                 730                 735     


Leu Asn Asn Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His Leu Ala 
            740                 745                 750         


Gly Gly Ile Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
    770                 775                 780                 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
785                 790                 795                 800 


Tyr Val Asn Trp Ile Glu Arg Glu Met Arg Asn Asp 
                805                 810         


<210>  37
<211>  811
<212>  PRT
<213>  Erinaceus europaeus

<400>  37

Met Gln Arg Lys Glu Leu Val Leu Leu Phe Leu Leu Phe Leu Gln Pro 
1               5                   10                  15      


Gly His Gly Ile Pro Leu Asp Asp Tyr Val Thr Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Ser Ser Ser Thr Lys Lys Gln Leu Ser Val Gly Ser Thr Glu Glu 
        35                  40                  45              


Cys Ala Val Lys Cys Glu Lys Glu Thr Ser Phe Ile Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Ser Thr Pro Val Leu Arg Met Arg Asp Val Ile Leu Phe Glu Lys 
                85                  90                  95      


Lys Met Tyr Leu Ser Glu Cys Lys Val Gly Asn Gly Lys Tyr Tyr Arg 
            100                 105                 110         


Gly Thr Val Ser Lys Thr Lys Thr Gly Leu Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ala Glu Thr Pro His Lys Pro Arg Phe Ser Pro Asp Glu Asn Pro Ser 
    130                 135                 140                 


Glu Gly Leu Asp Gln Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Lys 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Met Asp Pro Glu Val Arg Tyr Glu Tyr Cys 
                165                 170                 175     


Glu Ile Ile Gln Cys Glu Asp Glu Cys Met His Cys Ser Gly Gln Asn 
            180                 185                 190         


Tyr Val Gly Lys Ile Ser Arg Thr Met Ser Gly Leu Glu Cys Gln Pro 
        195                 200                 205             


Trp Asp Ser Gln Ile Pro His Pro His Gly Phe Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Ser Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Met Asp Arg Asn Lys Arg Trp Glu Tyr 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Pro Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Met Gly Asn Gly Glu His Tyr Gln Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly Leu Thr Cys Gln Arg Trp Gly Glu Gln Ser Pro 
    290                 295                 300                 


His Arg His Asp Arg Thr Pro Glu Asn Tyr Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Pro Ala Pro Trp Cys Phe 
                325                 330                 335     


Thr Thr Asn Ser Ser Val Arg Trp Glu Phe Cys Lys Ile Pro Asp Cys 
            340                 345                 350         


Val Ser Ser Ala Ser Glu Thr Glu His Ser Asp Ala Pro Val Ile Val 
        355                 360                 365             


Pro Pro Glu Gln Thr Pro Val Val Gln Glu Cys Tyr Gln Gly Asn Gly 
    370                 375                 380                 


Gln Ser Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Lys Lys Cys 
385                 390                 395                 400 


Gln Pro Trp Thr Ser Met Arg Pro His Arg His Ser Lys Thr Pro Glu 
                405                 410                 415     


Asn Tyr Pro Asp Ala Asp Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp 
            420                 425                 430         


Gly Asp Lys Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp 
        435                 440                 445             


Glu Phe Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Met Ser Ala Thr 
    450                 455                 460                 


Asn Ser Ser Pro Val Gln Val Ser Ser Ala Ser Glu Ser Ser Glu Gln 
465                 470                 475                 480 


Asp Cys Ile Ile Asp Asn Gly Lys Gly Tyr Arg Gly Thr Lys Ala Thr 
                485                 490                 495     


Thr Gly Ala Gly Thr Pro Cys Gln Ala Trp Ala Ala Gln Glu Pro His 
            500                 505                 510         


Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Asp Leu Gln 
        515                 520                 525             


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Asn Gly Pro Trp Cys 
    530                 535                 540                 


Tyr Thr Thr Asn Pro Arg Lys Leu Phe Asp Tyr Cys Asp Ile Pro His 
545                 550                 555                 560 


Cys Val Ser Pro Ser Ser Ala Asp Cys Gly Lys Pro Lys Val Glu Pro 
                565                 570                 575     


Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Pro His 
            580                 585                 590         


Ser Trp Pro Trp Gln Val Ser Leu Arg Arg Phe Gly Gln His Phe Cys 
        595                 600                 605             


Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Val Thr Ala Ala His Cys 
    610                 615                 620                 


Leu Glu Lys Phe Ser Asn Pro Ala Ile Tyr Lys Val Val Leu Gly Ala 
625                 630                 635                 640 


His Gln Glu Thr Arg Leu Glu Arg Asp Val Gln Ile Lys Gly Val Thr 
                645                 650                 655     


Lys Met Phe Leu Glu Pro Tyr Arg Ala Asp Ile Ala Leu Leu Lys Leu 
            660                 665                 670         


Ser Ser Pro Ala Ile Ile Thr Asp Lys Ile Ile Pro Ala Cys Leu Pro 
        675                 680                 685             


Asn Ser Asn Tyr Met Val Ala Asp Arg Ser Leu Cys Tyr Ile Thr Gly 
    690                 695                 700                 


Trp Gly Glu Thr Lys Gly Thr Tyr Gly Ala Gly Leu Leu Lys Glu Ala 
705                 710                 715                 720 


Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Gln Glu Leu Leu 
                725                 730                 735     


Asn Gly Arg Val Arg Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly 
            740                 745                 750         


Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe 
        755                 760                 765             


Glu Lys Asp Arg Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly 
    770                 775                 780                 


Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Tyr 
785                 790                 795                 800 


Val Ser Trp Leu Gln Asp Val Met Arg Asn Asn 
                805                 810     


<210>  38
<211>  780
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  38

Met Glu Gln Arg Ala Val Val Leu Leu Leu Leu Leu Leu Leu Lys Pro 
1               5                   10                  15      


Gly Gln Ala Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Phe Thr Lys Lys Gln Leu Gly Ala Ala Ser Ile Ala Glu 
        35                  40                  45              


Cys Ala Ala Arg Cys Glu Ala Glu Thr Glu Phe Thr Cys Arg Ser Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Val Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Ser Ser Ala Ile Ile Arg Arg Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Arg Met Tyr Leu Ser Glu Cys Lys Ile Gly Asn Gly Arg Ser Tyr Arg 
            100                 105                 110         


Gly Thr Lys Ser Lys Thr Lys Thr Gly Phe Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Ser Tyr Pro His Lys Pro Asn Phe Thr Pro Lys Lys Tyr Pro Ala 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asn Pro Asp Glu Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Asp Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Met Ser Gly Ile Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Met Asp Pro Lys Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Pro Ser Gly Pro Thr 
            260                 265                 270         


His Gln Cys Leu Lys Gly Arg Gly Glu Ser Tyr Arg Gly Lys Val Ala 
        275                 280                 285             


Arg Thr Lys Ser Gly Leu Thr Cys Gln Arg Trp Ser Glu Gln Thr Pro 
    290                 295                 300                 


His Leu His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asp Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Ser Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asp Ser Lys Val Arg Trp Glu His Cys Asp Ile Pro Ser Cys 
            340                 345                 350         


Ala Ser Ser Pro Thr Ser Val Glu Pro Leu Asp Ala Pro Ala Pro Pro 
        355                 360                 365             


Glu Glu Thr Pro Val Val Gln Glu Cys Tyr Gln Gly Asn Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Arg Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Leu Ser Met Thr Pro His Arg His Gln Arg Thr Pro Gln Asn Tyr 
                405                 410                 415     


Pro Asn Ala Asp Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Asp Asp 
            420                 425                 430         


Ile Arg Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Arg Arg Cys Ser Glu Pro Ala Ala Ser Pro Ala Ala Thr 
    450                 455                 460                 


Val Pro Thr Ala Gln Leu Pro Arg Pro Glu Ala Thr Phe Glu Pro Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Lys Ala Thr Thr 
                485                 490                 495     


Ala Asp Gly Thr Pro Cys Gln Gly Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Asn Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Arg 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Thr Asn Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Met Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ser Ser Ser Ser Tyr Asp Cys Gly Lys Pro Lys Val Glu Pro Lys 
                565                 570                 575     


Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala Asn Pro His Ser 
            580                 585                 590         


Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg Thr Gly Gln His Phe Cys 
        595                 600                 605             


Gly Gly Thr Leu Ile Ala Pro Glu Trp Val Leu Thr Ala Ala His Cys 
    610                 615                 620                 


Leu Glu Lys Tyr Pro Arg Pro Ser Ala Tyr Arg Val Ile Leu Gly Ala 
625                 630                 635                 640 


His Lys Glu Val Asn Leu Glu Leu Asp Val Gln Asp Ile Asp Val Ala 
                645                 650                 655     


Lys Leu Phe Leu Glu Pro Ser Arg Ala Asp Ile Ala Leu Met Lys Leu 
            660                 665                 670         


Ser Ser Leu Glu Trp Ala Trp Thr Tyr Gly Ala Gly Leu Leu Lys Glu 
        675                 680                 685             


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Phe Glu Tyr 
    690                 695                 700                 


Leu Asn Gly Arg Val Arg Ser Thr Glu Leu Cys Ala Gly His Leu Ala 
705                 710                 715                 720 


Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                725                 730                 735     


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
            740                 745                 750         


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
        755                 760                 765             


Phe Val Asp Trp Ile Glu Arg Thr Met Arg Asn Asn 
    770                 775                 780 


<210>  39
<211>  827
<212>  PRT
<213>  Pan troglodytes

<400>  39

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Tyr Phe 
    50                  55                  60                  


His Cys Arg Cys Thr Tyr Pro Glu Ile Cys Asn Ser Asp Gly Lys Ala 
65                  70                  75                  80  


Phe Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn 
                85                  90                  95      


Arg Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu 
            100                 105                 110         


Lys Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr 
        115                 120                 125             


Arg Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp 
    130                 135                 140                 


Ser Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro 
145                 150                 155                 160 


Ser Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro 
                165                 170                 175     


Gln Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr 
            180                 185                 190         


Cys Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu 
        195                 200                 205             


Asn Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln 
    210                 215                 220                 


Ala Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys 
225                 230                 235                 240 


Phe Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Gly 
                245                 250                 255     


Glu Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu 
            260                 265                 270         


Leu Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro 
        275                 280                 285             


Thr Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val 
    290                 295                 300                 


Ala Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr 
305                 310                 315                 320 


Pro His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu 
                325                 330                 335     


Asp Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys 
            340                 345                 350         


His Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser 
        355                 360                 365             


Cys Asp Ser Ser Leu Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro 
    370                 375                 380                 


Pro Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln 
385                 390                 395                 400 


Ser Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln 
                405                 410                 415     


Ser Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn 
            420                 425                 430         


Tyr Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala 
        435                 440                 445             


Asp Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu 
    450                 455                 460                 


Tyr Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala 
465                 470                 475                 480 


Pro Pro Pro Val Val Gln Leu Pro Asn Val Glu Thr Pro Ser Glu Glu 
                485                 490                 495     


Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr 
            500                 505                 510         


Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His 
        515                 520                 525             


Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu 
    530                 535                 540                 


Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys 
545                 550                 555                 560 


Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln 
                565                 570                 575     


Cys Ala Ser Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys 
            580                 585                 590         


Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser 
        595                 600                 605             


Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Leu Gly Met His Phe Cys 
    610                 615                 620                 


Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys 
625                 630                 635                 640 


Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala 
                645                 650                 655     


His Gln Glu Val Lys Leu Glu Pro His Val Gln Glu Ile Glu Val Ser 
            660                 665                 670         


Arg Leu Phe Leu Glu Pro Thr Arg Thr Asp Ile Ala Leu Leu Lys Leu 
        675                 680                 685             


Ser Ser Pro Ala Ile Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro 
    690                 695                 700                 


Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly 
705                 710                 715                 720 


Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala 
                725                 730                 735     


Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Asn Glu Phe Leu 
            740                 745                 750         


Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly 
        755                 760                 765             


Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe 
    770                 775                 780                 


Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly 
785                 790                 795                 800 


Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe 
                805                 810                 815     


Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
            820                 825         


<210>  40
<211>  769
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  40

Phe Val Arg Arg Ser Phe Glu Tyr His Ser Lys Glu Gln Gln Cys Ala 
1               5                   10                  15      


Ile Met Ala Glu Asn Ser Lys Ser Ser Ala Val Phe Arg Met Arg Asp 
            20                  25                  30          


Val Ile Leu Phe Gln Lys Arg Ile Tyr Leu Ser Glu Cys Lys Thr Gly 
        35                  40                  45              


Asn Gly Lys Thr Tyr Arg Gly Thr Met Ser Lys Thr Lys Asn Gly Val 
    50                  55                  60                  


Ala Cys Gln Lys Trp Ser Asp Thr Phe Pro His Lys Pro Asn Tyr Thr 
65                  70                  75                  80  


Pro Glu Lys His Pro Leu Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn 
                85                  90                  95      


Pro Asp Asn Asp Glu Lys Gly Pro Trp Cys Tyr Thr Thr Asp Pro Asn 
            100                 105                 110         


Gln Arg Phe Asp Tyr Cys Ser Ile Pro Gln Cys Glu Asp Glu Cys Met 
        115                 120                 125             


His Cys Ser Gly Glu Asn Tyr Glu Gly Lys Val Ser Lys Thr Lys Ser 
    130                 135                 140                 


Gly Leu Glu Cys Gln Ala Trp Asn Ser Gln Thr Pro His Ala His Gly 
145                 150                 155                 160 


Tyr Ile Pro Ser Lys Phe Pro Asn Lys Asn Leu Lys Met Asn Tyr Cys 
                165                 170                 175     


Arg Asn Pro Asp Gly Glu Pro Arg Pro Trp Cys Phe Thr Met Asp Pro 
            180                 185                 190         


Asn Lys Arg Trp Glu Phe Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro 
        195                 200                 205             


Pro Pro Ser Gly Pro Thr Tyr Gln Cys Leu Lys Gly Lys Gly Glu Asn 
    210                 215                 220                 


Tyr Arg Gly Lys Val Ser Val Thr Ala Ser Gly His Thr Cys Gln Arg 
225                 230                 235                 240 


Trp Ser Glu Gln Thr Pro His Lys His Asn Arg Thr Pro Glu Asn Phe 
                245                 250                 255     


Pro Cys Lys Asn Leu Asp Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
            260                 265                 270         


Ser Ala Pro Trp Cys Tyr Thr Thr Asp Ser Glu Val Arg Trp Glu His 
        275                 280                 285             


Cys Ser Ile Pro Ser Cys Glu Ser Ser Pro Leu Thr Leu Asp Ser Leu 
    290                 295                 300                 


Asp Thr Pro Ala Ser Ile Pro Pro Glu Gln Thr Pro Val Val Gln Glu 
305                 310                 315                 320 


Cys Tyr Gln Gly Asn Gly Gln Thr Tyr Arg Gly Thr Ser Ser Thr Thr 
                325                 330                 335     


Ile Thr Gly Lys Lys Cys Gln Pro Trp Ser Ser Met Ser Pro His Arg 
            340                 345                 350         


His Glu Lys Thr Pro Glu Arg Phe Pro Asn Ala Gly Leu Thr Met Asn 
        355                 360                 365             


Tyr Cys Arg Asn Pro Asp Gly Asp Lys Ser Pro Trp Cys Tyr Thr Thr 
    370                 375                 380                 


Asp Pro Ser Val Arg Trp Glu Phe Cys Asn Leu Lys Lys Cys Leu Asp 
385                 390                 395                 400 


Thr Glu Glu Ser Gly Thr Ser Ser Pro Thr Val Pro Gln Val Pro Ser 
                405                 410                 415     


Gly Glu Glu Pro Ser Glu Thr Asp Cys Met Phe Gly Asn Gly Lys Gly 
            420                 425                 430         


Tyr Arg Gly Lys Lys Ala Thr Thr Val Leu Gly Ile Pro Cys Gln Glu 
        435                 440                 445             


Trp Thr Ala Gln Glu Pro His Lys His Ser Ile Phe Thr Pro Glu Thr 
    450                 455                 460                 


Asn Pro Arg Ala Glu His Leu Leu Cys Pro Thr Cys Leu Val Pro Ser 
465                 470                 475                 480 


Val Pro Thr Val Phe Phe Phe Phe Phe Phe Phe Phe Leu Phe Leu Asp 
                485                 490                 495     


Val Asn Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Phe Asp 
            500                 505                 510         


Tyr Cys Asp Ile Pro Gln Cys Ala Ser Gly Ser Phe Asp Cys Gly Lys 
        515                 520                 525             


Pro Gln Val Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys 
    530                 535                 540                 


Val Ala Asn Pro His Ser Trp Pro Trp Gln Ile Ser Leu Arg Thr Arg 
545                 550                 555                 560 


Phe Gly Gln His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val 
                565                 570                 575     


Leu Thr Ala Ala His Cys Leu Glu Arg Ser Pro Arg Pro Ala Ala Tyr 
            580                 585                 590         


Lys Val Ile Leu Gly Ala His Arg Glu Phe Asn Leu Glu Ser Asp Val 
        595                 600                 605             


Gln Glu Ile Glu Val Ser Lys Leu Phe Leu Glu Pro Thr His Ala Asp 
    610                 615                 620                 


Ile Ala Leu Ile Lys Leu Gln Ser Pro Ala Val Leu Thr Ser Lys Val 
625                 630                 635                 640 


Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr 
                645                 650                 655     


Leu Cys Tyr Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Val 
            660                 665                 670         


Gly Leu Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys 
        675                 680                 685             


Asn Arg Tyr Glu Tyr Leu Asn Gly Lys Val Lys Ser Thr Glu Leu Cys 
    690                 695                 700                 


Ala Gly Asn Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly 
705                 710                 715                 720 


Gly Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val 
                725                 730                 735     


Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr 
            740                 745                 750         


Val Arg Val Ser Arg Phe Val Thr Trp Ile Glu Glu Ile Met Arg Asn 
        755                 760                 765             


Asn 
    


<210>  41
<211>  334
<212>  PRT
<213>  Papio hamadryas

<400>  41

Ile Arg Leu Asp Cys Met Phe Gly Asn Gly Lys Arg Tyr Arg Gly Lys 
1               5                   10                  15      


Lys Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Glu Trp Ala Ala Lys 
            20                  25                  30          


Glu Pro His Ser His Leu Ile Phe Thr Pro Glu Thr Tyr Pro Arg Ala 
        35                  40                  45              


Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly 
    50                  55                  60                  


Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp 
65                  70                  75                  80  


Val Pro Gln Cys Ala Ser Ser Ser Phe Asp Cys Gly Lys Pro Gln Val 
                85                  90                  95      


Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His 
            100                 105                 110         


Ala His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met 
        115                 120                 125             


His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala 
    130                 135                 140                 


Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Phe Tyr Lys Val Ile 
145                 150                 155                 160 


Leu Gly Ala His Gln Glu Val Arg Leu Glu Pro His Val Gln Glu Ile 
                165                 170                 175     


Glu Val Ser Lys Met Phe Ser Glu Pro Ala Gly Ala Asp Ile Ala Leu 
            180                 185                 190         


Leu Lys Leu Ser Ser Pro Ala Ile Ile Thr Asp Lys Val Ile Pro Ala 
        195                 200                 205             


Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe 
    210                 215                 220                 


Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Tyr Gly Ala Gly Leu Leu 
225                 230                 235                 240 


Lys Glu Ala Arg Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr 
                245                 250                 255     


Glu Phe Leu Asn Gly Arg Val Lys Ser Thr Glu Leu Cys Ala Gly His 
            260                 265                 270         


Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
        275                 280                 285             


Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp 
    290                 295                 300                 


Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val 
305                 310                 315                 320 


Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                325                 330                 


<210>  42
<211>  343
<212>  PRT
<213>  Ovis aries

<400>  42

Ala Pro Gln Ala Pro Ser Val Glu Asn Pro Pro Glu Ala Asp Cys Met 
1               5                   10                  15      


Leu Gly Ile Gly Lys Gly Tyr Arg Gly Lys Lys Ala Thr Thr Val Ala 
            20                  25                  30          


Gly Val Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Arg His Gly 
        35                  40                  45              


Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr 
    50                  55                  60                  


Cys Arg Asn Pro Asp Gly Asp Val Asn Gly Pro Trp Cys Tyr Thr Thr 
65                  70                  75                  80  


Asn Pro Arg Lys Leu Phe Asp Tyr Cys Asp Ile Pro Gln Cys Glu Ser 
                85                  90                  95      


Ser Phe Asp Cys Gly Lys Pro Lys Val Glu Pro Lys Lys Cys Pro Ala 
            100                 105                 110         


Arg Val Val Gly Gly Cys Val Ala Thr Pro His Ser Trp Pro Trp Gln 
        115                 120                 125             


Val Ser Leu Arg Arg Arg Ser Arg Glu His Phe Cys Gly Gly Thr Leu 
    130                 135                 140                 


Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Asp Ser Ile 
145                 150                 155                 160 


Leu Gly Pro Ser Phe Tyr Thr Val Ile Leu Gly Ala His Tyr Glu Met 
                165                 170                 175     


Ala Arg Glu Ala Ser Val Gln Glu Ile Pro Val Ser Arg Leu Phe Leu 
            180                 185                 190         


Glu Pro Ser Arg Ala Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala 
        195                 200                 205             


Val Ile Thr Asp Glu Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr 
    210                 215                 220                 


Val Val Ala Asp Lys Thr Val Cys Tyr Ile Thr Gly Trp Gly Glu Thr 
225                 230                 235                 240 


Gln Gly Thr Phe Gly Val Gly Arg Leu Lys Glu Ala Arg Leu Pro Val 
                245                 250                 255     


Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Tyr Leu Asn Gly Arg Val 
            260                 265                 270         


Lys Ser Thr Glu Leu Cys Ala Gly Asp Leu Ala Gly Gly Thr Asp Ser 
        275                 280                 285             


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys 
    290                 295                 300                 


Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro 
305                 310                 315                 320 


Asn Lys Pro Gly Val Tyr Val Arg Val Ser Thr Tyr Val Pro Trp Ile 
                325                 330                 335     


Glu Glu Thr Met Arg Arg Tyr 
            340             


