                         SEQUENCE LISTING

<110>  Complix NV
 
<120>  PTHrP-binding Alphabodies

<130>  142523

<150>  GB 0911892.8
<151>  2009-07-08

<160>  55    

<170>  PatentIn version 3.4

<210>  1
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg 
    130                 135                 


<210>  2
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Arg His 
    130                 135                 140     


<210>  3
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Thr Ala Leu Leu Trp 
    130                 135                 140                 


Gly Leu Lys Lys Lys Lys Glu Asn Asn Arg Arg Thr His His Met Gln 
145                 150                 155                 160 


Leu Met Ile Ser Leu Phe Lys Ser Pro Leu Leu Leu Leu 
                165                 170             


<210>  4
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  scAB013_L16

<400>  4

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Met Ser Ile Glu 
        35                  40                  45              


Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Ala Ala Ile 
    50                  55                  60                  


Gln Lys Gln Ile Tyr Arg Met Thr Gly Gly Ser Gly Gly Gly Ser Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Ser Gly Met Ser Ile Glu Glu Ile Gln Lys 
                85                  90                  95      


Gln Ile Ala Ala Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile 
            100                 105                 110         


Tyr Arg Met Thr Pro 
        115         


<210>  5
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  scAB140_L14

<400>  5

Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Tyr Arg Met Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala 
        35                  40                  45              


Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Gly Gly Ser Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Met Asp Ile Gln Gln Ile 
65                  70                  75                  80  


Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Pro 
                85                  90                  95      


<210>  6
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  bL4_PTH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinylation

<400>  6

Gly Gly Ser Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly 
1               5                   10                  15      


Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu 
            20                  25                  30          


Gln Asp Val His Asn Phe 
        35              


<210>  7
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  bL4_PTHrP


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinylation

<400>  7

Gly Gly Ser Gly Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
1               5                   10                  15      


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
            20                  25                  30          


Ala Glu Ile His Thr Ala 
        35              


<210>  8
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  9
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala 
        


<210>  10
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  scAB_69_B11_R5

<400>  10

Met Gly His His His His His His His His His His Ser Ser Gly His 
1               5                   10                  15      


Ile Glu Gly Arg His Met Ser Ile Glu Glu Ile Gln Lys Asp Ile Ala 
            20                  25                  30          


Met Ile Gln Glu Gly Ile Ala Thr Ile Gln Lys Trp Ile Tyr Gln Met 
        35                  40                  45              


Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gly Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys 
65                  70                  75                  80  


Gln Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Met Ser Ile 
            100                 105                 110         


Glu Glu Ile Gln Lys Gln Ile Asp Ala Ile Tyr Glu Gln Ile Phe Ala 
        115                 120                 125             


Ile Ala Lys Gln Ile Ile Ala Met Thr Pro 
    130                 135             


<210>  11
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  PelB leader sequence

<400>  11

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala 
            20  


<210>  12
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of scLib013_L16_AC11


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is any natural amino acid

<400>  12

Met Ser Ile Glu Glu Ile Gln Lys Xaa Ile Ala Xaa Ile Gln Glu Xaa 
1               5                   10                  15      


Ile Ala Xaa Ile Gln Lys Xaa Ile Tyr Xaa Met Thr 
            20                  25              


<210>  13
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  16-residue linker sequence

<400>  13

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  14
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence derived from scAB013_L16

<400>  14

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr 
            20                  25              


<210>  15
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of scLib013_L16_AC11


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is any natural amino acid

<400>  15

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Xaa Ala Ile Xaa Glu Gln 
1               5                   10                  15      


Ile Xaa Ala Ile Xaa Lys Gln Ile Xaa Ala Met Thr Pro 
            20                  25                  


<210>  16
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  His-tag sequence

<400>  16

Gly Gly Ser Gly Gly Ala Ala Ala His His His His His His Gly Arg 
1               5                   10                  15      


Ala Glu 
        


<210>  17
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  scLib013_L16_AC11


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  X is any natural amino acid

<400>  17

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ser Ile Glu Glu Ile Gln Lys Xaa Ile Ala Xaa 
            20                  25                  30          


Ile Gln Glu Xaa Ile Ala Xaa Ile Gln Lys Xaa Ile Tyr Xaa Met Thr 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
65                  70                  75                  80  


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Met Ser Ile Glu 
            100                 105                 110         


Glu Ile Gln Lys Gln Ile Xaa Ala Ile Xaa Glu Gln Ile Xaa Ala Ile 
        115                 120                 125             


Xaa Lys Gln Ile Xaa Ala Met Thr Pro Gly Gly Ser Gly Gly Ala Ala 
    130                 135                 140                 


Ala His His His His His His Gly Arg Ala Glu 
145                 150                 155 


<210>  18
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of scLib140_L14_AC7


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is any natural amino acid

<400>  18

Met Asp Ile Gln Gln Ile Gln Lys Xaa Ile Ala Xaa Ile Gln Glu Xaa 
1               5                   10                  15      


Ile Tyr Xaa Met Thr 
            20      


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  14-residue linker sequence

<400>  19

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  


<210>  20
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence derived from scAB140_L14

<400>  20

Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Tyr Ala Met Thr 
            20      


<210>  21
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of scLib140_L14_AC27


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is any natural amino acid

<400>  21

Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Xaa Ala Ile Xaa Glu Gln 
1               5                   10                  15      


Ile Xaa Ala Met Thr Pro 
            20          


<210>  22
<211>  130
<212>  PRT
<213>  Artificial

<220>
<223>  scLib140_L14_AC7


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is any natural amino acid

<400>  22

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Asp Ile Gln Gln Ile Gln Lys Xaa Ile Ala Xaa 
            20                  25                  30          


Ile Gln Glu Xaa Ile Tyr Xaa Met Thr Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Met Asp Ile Gln Gln Ile Gln Lys Gln 
    50                  55                  60                  


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr Gly Gly Ser Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Met Asp Ile Gln Gln Ile 
                85                  90                  95      


Gln Lys Gln Ile Xaa Ala Ile Xaa Glu Gln Ile Xaa Ala Met Thr Pro 
            100                 105                 110         


Gly Gly Ser Gly Gly Ala Ala Ala His His His His His His Gly Arg 
        115                 120                 125             


Ala Glu 
    130 


<210>  23
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of scLib013_L16_C9


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(19)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  Xaa is any natural amino acid

<400>  23

Met Ser Ile Glu Glu Ile Gln Xaa Gln Ile Xaa Xaa Ile Gln Xaa Gln 
1               5                   10                  15      


Ile Xaa Xaa Ile Gln Xaa Gln Ile Xaa Xaa Met Thr Pro 
            20                  25                  


<210>  24
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  scLib013_L16_C9


<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (119)..(120)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (126)..(127)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (133)..(134)
<223>  Xaa is any natural amino acid

<400>  24

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala 
            20                  25                  30          


Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
65                  70                  75                  80  


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Ala Met Thr Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Met Ser Ile Glu 
            100                 105                 110         


Glu Ile Gln Xaa Gln Ile Xaa Xaa Ile Gln Xaa Gln Ile Xaa Xaa Ile 
        115                 120                 125             


Gln Xaa Gln Ile Xaa Xaa Met Thr Pro Gly Gly Ser Gly Gly Ala Ala 
    130                 135                 140                 


Ala His His His His His His Gly Arg Ala Glu 
145                 150                 155 


<210>  25
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence of scAB013_L16

<400>  25

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr 
            20                  25              


<210>  26
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Partially randomized 16-residue linker sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(12)
<223>  Xaa is any natural amino acid

<400>  26

Gly Gly Ser Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Ser Gly 
1               5                   10                  15      


<210>  27
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence of scAB013_L16

<400>  27

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Pro 
            20                  25                  


<210>  28
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  scLib013_L16_LBC8


<220>
<221>  MISC_FEATURE
<222>  (97)..(104)
<223>  Xaa is any natural amino acid

<400>  28

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala 
            20                  25                  30          


Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
65                  70                  75                  80  


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Gly Gly Ser Gly 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Ser Gly Met Ser Ile Glu 
            100                 105                 110         


Glu Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Ala Ala Ile 
        115                 120                 125             


Gln Lys Gln Ile Tyr Arg Met Thr Pro Gly Gly Ser Gly Gly Ala Ala 
    130                 135                 140                 


Ala His His His His His His Gly Arg Ala Glu 
145                 150                 155 


<210>  29
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence of scAB140_L14

<400>  29

Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Tyr Arg Met Thr 
            20      


<210>  30
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Fully randomized 14-residue linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  Xaa is any natural amino acid

<400>  30

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  31
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence of scAB140_L14

<400>  31

Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln 
1               5                   10                  15      


Ile Tyr Arg Met Thr Pro 
            20          


<210>  32
<211>  130
<212>  PRT
<213>  Artificial

<220>
<223>  scLib140_L14_LBC14


<220>
<221>  MISC_FEATURE
<222>  (77)..(90)
<223>  Xaa is any natural amino acid

<400>  32

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Asp Ile Gln Gln Ile Gln Lys Gln Ile Ala Ala 
            20                  25                  30          


Ile Gln Lys Gln Ile Tyr Arg Met Thr Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Met Asp Ile Gln Gln Ile Gln Lys Gln 
    50                  55                  60                  


Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Asp Ile Gln Gln Ile 
                85                  90                  95      


Gln Lys Gln Ile Ala Ala Ile Gln Lys Gln Ile Tyr Arg Met Thr Pro 
            100                 105                 110         


Gly Gly Ser Gly Gly Ala Ala Ala His His His His His His Gly Arg 
        115                 120                 125             


Ala Glu 
    130 


<210>  33
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence derived from scAB013_L16

<400>  33

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ser Ser Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ser Ser Ile Gln Lys Gln Ile Tyr Arg Met Thr 
            20                  25              


<210>  34
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Partially randomized 16-residue linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gly or Ser

<400>  34

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
1               5                   10                  15      


<210>  35
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Helix sequence derived from scAB013_L16

<400>  35

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ser Ser Ile Gln Lys Gln 
1               5                   10                  15      


Ile Ser Ser Ile Gln Lys Gln Ile Tyr Arg Met Thr Pro 
            20                  25                  


<210>  36
<211>  137
<212>  PRT
<213>  Artificial

<220>
<223>  scLibISSI_L16_LBCAlt


<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa is any natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa is Gly or Ser

<400>  36

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ser Ser 
            20                  25                  30          


Ile Gln Lys Gln Ile Ser Ser Ile Gln Lys Gln Ile Tyr Arg Met Thr 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Ser Ser Ile Gln Lys Gln 
65                  70                  75                  80  


Ile Ser Ser Ile Gln Lys Gln Ile Tyr Arg Met Thr Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Met Ser Ile Glu 
            100                 105                 110         


Glu Ile Gln Lys Gln Ile Ser Ser Ile Gln Lys Gln Ile Ser Ser Ile 
        115                 120                 125             


Gln Lys Gln Ile Tyr Arg Met Thr Pro 
    130                 135         


<210>  37
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 1_C1

<400>  37

Met Ser Ile Glu Glu Ile Gln Lys Asn Ile Ala Asn Ile Gln Glu Val 
1               5                   10                  15      


Ile Ala Glx Ile Gln Lys Met Ile Tyr Leu Met Thr 
            20                  25              


<210>  38
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 1_C1

<400>  38

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Asp Ala Ile Ala Glu Gln 
1               5                   10                  15      


Ile Trp Ala Ile Gly Lys Gln Ile Leu Ala Met Thr Pro 
            20                  25                  


<210>  39
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 21_G6

<400>  39

Met Ser Ile Glu Glu Ile Gln Lys Asp Ile Ala Ser Ile Gln Glu Val 
1               5                   10                  15      


Ile Ala Leu Ile Gln Lys Arg Ile Tyr Thr Met Thr 
            20                  25              


<210>  40
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 21_G6

<400>  40

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Thr Ala Ile Ala Glu Gln 
1               5                   10                  15      


Ile Met Ala Ile Gly Lys Gln Ile Leu Ala Met Thr Pro 
            20                  25                  


<210>  41
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody PTH_2_D6

<400>  41

Met Ser Ile Glu Glu Ile Gln Lys Asp Ile Ala Leu Ile Gln Glu Asn 
1               5                   10                  15      


Ile Ala Val Ile Gln Lys Arg Ile Tyr Gly Met Thr 
            20                  25              


<210>  42
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody PTH_2_D6

<400>  42

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Leu Ala Ile Phe Glu Gln 
1               5                   10                  15      


Ile Tyr Ala Ile Arg Lys Gln Ile Met Ala Met Thr Pro 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 7_D2

<400>  43

Met Ser Ile Glu Glu Ile Gln Arg Gln Ile Leu Glu Ile Gln Trp Gln 
1               5                   10                  15      


Ile Trp Val Ile Leu Asn Gln Ile Ile Glu Met Thr Pro 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody PTH_2_F3

<400>  44

Met Ser Ile Glu Glu Ile Gln Arg Gln Ile Leu Val Ile Gln Trp Gln 
1               5                   10                  15      


Ile Phe Val Ile Leu Gly Gln Ile Tyr Asp Met Thr Pro 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 22_D7

<400>  45

Met Ser Ile Glu Glu Ile Gln Asp Gln Ile Leu Val Ile Gln Leu Gln 
1               5                   10                  15      


Ile Leu Leu Ile Gln Ser Gln Ile Glu Phe Met Thr Pro 
            20                  25                  


<210>  46
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 68_A11_R5

<400>  46

Met Ser Ile Glu Glu Ile Gln Lys Asp Ile Ala Met Ile Gln Glu Tyr 
1               5                   10                  15      


Ile Ala Val Ile Gln Lys Glx Ile Tyr Lys Met Thr 
            20                  25              


<210>  47
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 68_A11_R5

<400>  47

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Asp Ala Ile Leu Glu Gln 
1               5                   10                  15      


Ile Thr Ala Ile Ala Lys Gln Ile Leu Ala Met Thr Pro 
            20                  25                  


<210>  48
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 69_B11_R5

<400>  48

Met Ser Ile Glu Glu Ile Gln Lys Asp Ile Ala Met Ile Gln Glu Gly 
1               5                   10                  15      


Ile Ala Thr Ile Gln Lys Trp Ile Tyr Gln Met Thr 
            20                  25              


<210>  49
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 69_B11_R5

<400>  49

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Asp Ala Ile Tyr Glu Gln 
1               5                   10                  15      


Ile Phe Ala Ile Ala Lys Gln Ile Ile Ala Met Thr Pro 
            20                  25                  


<210>  50
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 53_E'8

<400>  50

Met Ser Ile Glu Glu Ile Gln Lys Val Ile Ala Glx Ile Gln Glu Ser 
1               5                   10                  15      


Ile Ala Val Ile Gln Lys Ala Ile Tyr Thr Met Thr 
            20                  25              


<210>  51
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 53_E'8

<400>  51

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Met Ala Ile Asn Glu Gln 
1               5                   10                  15      


Ile Leu Ala Ile Ile Lys Gln Ile Leu Ala Met Thr Pro 
            20                  25                  


<210>  52
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 65_C9_R5

<400>  52

Met Ser Ile Glu Glu Ile Gln Lys Val Ile Ala Glu Ile Gln Glu Thr 
1               5                   10                  15      


Ile Ala Thr Ile Gln Lys Asn Ile Tyr Val Met Thr 
            20                  25              


<210>  53
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 65_C9_R5

<400>  53

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Met Ala Ile Asn Glu Gln 
1               5                   10                  15      


Ile Ile Ala Ile Leu Lys Gln Ile Leu Ala Met Thr Pro 
            20                  25                  


<210>  54
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  A-helix of Alphabody 62_B2_R5

<400>  54

Met Ser Ile Glu Glu Ile Gln Lys Tyr Ile Ala Ala Ile Gln Glu Thr 
1               5                   10                  15      


Ile Ala Ile Ile Gln Lys Ser Ile Tyr Glu Met Thr 
            20                  25              


<210>  55
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  C-helix of Alphabody 62_B2_R5

<400>  55

Met Ser Ile Glu Glu Ile Gln Lys Gln Ile Phe Ala Ile Asn Glu Gln 
1               5                   10                  15      


Ile Ile Ala Ile Ile Lys Gln Ile Phe Ala Met Thr Pro 
            20                  25                  


