                         SEQUENCE LISTING

<110>  OPSONA THERAPEUTICS LIMITED
 
<120>  HUMANISED ANTIBODIES TO TOLL-LIKE RECEPTOR 2 AND USES THEREOF

<130>  P108456.WO.01/GST

<150>  IE 2009/0514
<151>  2009-07-06

<150>  US 61/270239
<151>  2009-07-06

<160>  24     

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  2
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  3
<211>  1033
<212>  DNA
<213>  Homo sapiens

<400>  3
gacattgtgc tcacccaatc tccagctact ttgtctctgt ctccagggga gagagccacc       60

ctctcctgca gagccagtga aagtgttgaa tactatggca caagtttaat gcagtggtac      120

caacagaaac caggacagcc acccaaactc ctcatctttg gtgcatccaa cgtagaatct      180

ggggtccctg acaggttcag tggcagtggg tctgggacag acttcaccct caagatcagc      240

cgggtggagg ccgaggatgt tggaatgtat ttctgtcagc aaagtaggaa acttccgtgg      300

acgttcggtg gaggcaccaa ggtggaaatc aaacgtgagt agaatttaaa ctttgcttcc      360

tcagttggat cccgcaattc taaactctga gggggtcgga tgacgtggcc attctttgcc      420

taaagcattg agtttactgc aaggtcagaa aagcatgcaa agccctcaga atggctgcaa      480

agagctccaa caaaacaatt tagaacttta ttaaggaata gggggaagct aggaagaaac      540

tcaaaacatc aagattttaa atacgcttct tggtctcctt gctataatta tctgggataa      600

gcatgctgtt ttctgtctgt ccctaacatg ccctgtgatt atccgcaaac aacacaccca      660

agggcagaac tttgttactt aaacaccatc ctgtttgctt ctttcctcag gaactgtggc      720

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc      780

tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga      840

taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag      900

cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt      960

ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag     1020

gggagagtgt tag                                                        1033


<210>  4
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  5
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  6
<211>  2163
<212>  DNA
<213>  Homo sapiens

<400>  6
caggttcagc tggtgcagtc tggatctgag ctgaagaagc ctggggcgtc agtgaagttg       60

tcctgcaagg cttctggctt caccttcaca acctacggta taaactgggt gaggcaggcc      120

cctggacagg gacttgagtg gattggatgg atttatccta gagatggtag tactaacttc      180

aatgagaatt tcaaggacag ggccacaatc actgtagaca catccgccag cacagcgtac      240

atggaactct ccagcctgag atctgaagac actgcggtct atttctgtgc aagactgact      300

ggtgggacat tccttgacta ttggggccag ggcaccactg tcacagtctc ctcaggtaag      360

ctttctgggg caggccgggc ctgactttgg ctgggggcag ggagggggct aaggtgacgc      420

aggtggcgcc agccaggtgc acacccaatg cccatgagcc cagacactgg accctgcatg      480

gaccatcgcg gatagacaag aaccgagggg cctctgcgcc ctgggcccag ctctgtccca      540

caccgcggtc acatggcacc acctctcttg cagcttccac caagggccca tccgtcttcc      600

ccctggcgcc ctgctccagg agcacctccg agagcacagc cgccctgggc tgcctggtca      660

aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg accagcggcg      720

tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc agcgtggtga      780

ccgtgccctc cagcagcttg ggcacgaaga cctacacctg caatgtagat cacaagccca      840

gcaacaccaa ggtggacaag agagttggtg agaggccagc acagggaggg agggtgtctg      900

ctggaagcca ggctcagccc tcctgcctgg acgcaccccg gctgtgcagc cccagcccag      960

ggcagcaagg caggccccat ctgtctcctc acctggaggc ctctgaccac cccactcatg     1020

ctcagggaga gggtcttctg gatttttcca ccaggctccg ggcagccaca ggctggatgc     1080

ccctacccca ggccctgcgc atacaggggc aggtgctgcg ctcagacctg ccaagagcca     1140

tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact ctccactccc     1200

tcagctcaga caccttctct cctcccagat ctgagtaact cccaatcttc tctctgcaga     1260

gtccaaatat ggtcccccat gcccaccatg cccaggtaag ccaacccagg cctcgccctc     1320

cagctcaagg cgggacaggt gccctagagt agcctgcatc cagggacagg ccccagccgg     1380

gtgctgacgc atccacctcc atctcttcct cagcacctga gttcctgggg ggaccatcag     1440

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca     1500

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg     1560

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt     1620

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca     1680

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca     1740

aaggtgggac ccacggggtg cgagggccac atggacagag gtcagctcgg cccaccctct     1800

gccctgggag tgaccgctgt gccaacctct gtccctacag ggcagccccg agagccacag     1860

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc     1920

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1980

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     2040

agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg     2100

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tctgggtaaa     2160

tga                                                                   2163


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Ala Ser Asn Val Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Gln Ser Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Tyr Gly Ile Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Thr Gly Gly Thr Phe Leu Asp Tyr 
1               5                   


<210>  13
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg Asn Gly 
1               5                   10                  15      


Ile Cys Lys Gly Ser 
            20      


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ser Cys Glu Phe Leu Ser Phe Thr Gln Glu Gln Gln 
1               5                   10              


<210>  15
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Glu Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  16
<211>  784
<212>  PRT
<213>  Mus musculus

<400>  16

Met Leu Arg Ala Leu Trp Leu Phe Trp Ile Leu Val Ala Ile Thr Val 
1               5                   10                  15      


Leu Phe Ser Lys Arg Cys Ser Ala Gln Glu Ser Leu Ser Cys Asp Ala 
            20                  25                  30          


Ser Gly Val Cys Asp Gly Arg Ser Arg Ser Phe Thr Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Ala Ala Met Lys Ser Leu Asp Leu Ser Phe Asn Lys Ile 
    50                  55                  60                  


Thr Tyr Ile Gly His Gly Asp Leu Arg Ala Cys Ala Asn Leu Gln Val 
65                  70                  75                  80  


Leu Met Leu Lys Ser Ser Arg Ile Asn Thr Ile Glu Gly Asp Ala Phe 
                85                  90                  95      


Tyr Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Asp Asn His Leu 
            100                 105                 110         


Ser Ser Leu Ser Ser Ser Trp Phe Gly Pro Leu Ser Ser Leu Lys Tyr 
        115                 120                 125             


Leu Asn Leu Met Gly Asn Pro Tyr Gln Thr Leu Gly Val Thr Ser Leu 
    130                 135                 140                 


Phe Pro Asn Leu Thr Asn Leu Gln Thr Leu Arg Ile Gly Asn Val Glu 
145                 150                 155                 160 


Thr Phe Ser Glu Ile Arg Arg Ile Asp Phe Ala Gly Leu Thr Ser Leu 
                165                 170                 175     


Asn Glu Leu Glu Ile Lys Ala Leu Ser Leu Arg Asn Tyr Gln Ser Gln 
            180                 185                 190         


Ser Leu Lys Ser Ile Arg Asp Ile His His Leu Thr Leu His Leu Ser 
        195                 200                 205             


Glu Ser Ala Phe Leu Leu Glu Ile Phe Ala Asp Ile Leu Ser Ser Val 
    210                 215                 220                 


Arg Tyr Leu Glu Leu Arg Asp Thr Asn Leu Ala Arg Phe Gln Phe Ser 
225                 230                 235                 240 


Pro Leu Pro Val Asp Glu Val Ser Ser Pro Met Lys Lys Leu Ala Phe 
                245                 250                 255     


Arg Gly Ser Val Leu Thr Asp Glu Ser Phe Asn Glu Leu Leu Lys Leu 
            260                 265                 270         


Leu Arg Tyr Ile Leu Glu Leu Ser Glu Val Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Leu Gly Asp Phe Asn Pro Ser Glu Ser Asp Val Val Ser 
    290                 295                 300                 


Glu Leu Gly Lys Val Glu Thr Val Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Gln Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Val Tyr Ser Leu Leu Glu 
                325                 330                 335     


Lys Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Ser Phe Ser Gln His Leu Lys Ser Leu Glu Phe Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Lys Gly 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Val Leu Ser Gln Asn His Leu Arg 
385                 390                 395                 400 


Ser Met Gln Lys Thr Gly Glu Ile Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Ser Leu Asp Ile Ser Arg Asn Thr Phe His Pro Met Pro Asp Ser Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Arg Phe Leu Asn Leu Ser Ser Thr Gly Ile 
        435                 440                 445             


Arg Val Val Lys Thr Cys Ile Pro Gln Thr Leu Glu Val Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asp Ser Phe Ser Leu Phe Leu Pro Arg Leu Gln 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Lys Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Phe Pro Val Leu Leu Val Met Lys Ile Arg Glu Asn Ala Val Ser 
            500                 505                 510         


Thr Phe Ser Lys Asp Gln Leu Gly Ser Phe Pro Lys Leu Glu Thr Leu 
        515                 520                 525             


Glu Ala Gly Asp Asn His Phe Val Cys Ser Cys Glu Leu Leu Ser Phe 
    530                 535                 540                 


Thr Met Glu Thr Pro Ala Leu Ala Gln Ile Leu Val Asp Trp Pro Asp 
545                 550                 555                 560 


Ser Tyr Leu Cys Asp Ser Pro Pro Arg Leu His Gly His Arg Leu Gln 
                565                 570                 575     


Asp Ala Arg Pro Ser Val Leu Glu Cys His Gln Ala Ala Leu Val Ser 
            580                 585                 590         


Gly Val Cys Cys Ala Leu Leu Leu Leu Ile Leu Leu Val Gly Ala Leu 
        595                 600                 605             


Cys His His Phe His Gly Leu Trp Tyr Leu Arg Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Lys Lys Ala Pro Cys Arg Asp Val Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Gln Asp Ser His Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Gln Leu Glu Asn Ser Asp Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Val Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Arg Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Val Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Arg Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Leu Asp Glu 
        755                 760                 765             


Gly Gln Gln Glu Val Phe Trp Val Asn Leu Arg Thr Ala Ile Lys Ser 
    770                 775                 780                 


<210>  17
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)

<400>  17
gac att gtg ctc acc caa tct cca gct act ttg tct ctg tct cca ggg         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gag aga gcc acc ctc tcc tgc aga gcc agt gaa agt gtt gaa tac tat         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr           
            20                  25                  30                    

ggc aca agt tta atg cag tgg tac caa cag aaa cca gga cag cca ccc        144
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro           
        35                  40                  45                        

aaa ctc ctc atc ttt ggt gca tcc aac gta gaa tct ggg gtc cct gac        192
Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Asp           
    50                  55                  60                            

agg ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc aag atc agc        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser           
65                  70                  75                  80            

cgg gtg gag gcc gag gat gtt gga atg tat ttc tgt cag caa agt agg        288
Arg Val Glu Ala Glu Asp Val Gly Met Tyr Phe Cys Gln Gln Ser Arg           
                85                  90                  95                

aaa ctt ccg tgg acg ttc ggt gga ggc acc aag gtg gaa atc aaa            333
Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  18
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  19
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)

<400>  19
cag gtt cag ctg gtg cag tct gga tct gag ctg aag aag cct ggg gcg         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ttg tcc tgc aag gct tct ggc ttc acc ttc aca acc tac         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr           
            20                  25                  30                    

ggt ata aac tgg gtg agg cag gcc cct gga cag gga ctt gag tgg att        144
Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tgg att tat cct aga gat ggt agt act aac ttc aat gag aat ttc        192
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe           
    50                  55                  60                            

aag gac agg gcc aca atc act gta gac aca tcc gcc agc aca gcg tac        240
Lys Asp Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gaa ctc tcc agc ctg aga tct gaa gac act gcg gtc tat ttc tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gca aga ctg act ggt ggg aca ttc ctt gac tat tgg ggc cag ggc acc        336
Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

act gtc aca gtc tcc tca                                                354
Thr Val Thr Val Ser Ser                                                   
        115                                                               


<210>  20
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  21
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  21

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Val Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Leu Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Gly Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Glu Glu Asp Val Gly Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  23
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Gly Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ala Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Asn Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Gly Thr Phe Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


