                         SEQUENCE LISTING

<110>  Temple University - Of the Commonwealth System of Higher 
       Education
       Otvos, Laszlo
 
<120>  Leptin Agonist and Methods of Use

<130>  035926-0393-00-WO (453422)

<150>  61/222,248
<151>  2009-07-01

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  tyrosine;  2-amino-3-(4-methoxyphenyl)propanoic acid; 
       3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid;  
       3-(4-methoxyphenyl)-2-(methylamino)propanoic acid;  
       3-monoiodotyrosine;  or 3,5-diiodotyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser or a saccharide-modified serine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Thr or a saccharide-modified threonine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Arg or 5-guanidino-2-(methylamino)pentanoic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  a non-natural amino acid

<400>  2

Xaa Xaa Xaa Glu Val Val Ala Leu Ser Xaa Xaa 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  3,5-diiodotyrosine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  O-alpha-(N-acetyl-galactosyl) threonine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Acp

<400>  3

Xaa Ser Xaa Glu Val Val Ala Leu Ser Arg Xaa 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  3,5-diiodotyrosine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  O-alpha-(N-acetyl-galactosyl) threonine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AcpNH2 (6-aminocapramide)

<400>  4

Xaa Ser Xaa Glu Val Val Ala Leu Ser Arg Xaa 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  5

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  6

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  7

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Tyr Lys Cys 
1               5                   10                  


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  8

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly 
1               5                   10          


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  9

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  10

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  11

Tyr Ala Arg Lys Ala Arg Arg Gln Ala Arg Arg 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  12

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  13

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Arg 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  14

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Ala 
1               5                   10      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  15

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  16

Arg Gln Ile Lys Ile Trp Phe Pro Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  17

Lys Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  18

Arg Arg Trp Arg Arg Trp Trp Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  19

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  aminopentanoic acid

<400>  20

Xaa Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  aminopentanoic acid

<400>  21

Xaa Arg Gln Ile Lys Ile Trp Phe Pro Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  22

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  23

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  24

Asp Ala Ala Thr Arg Ser Ala Ala Ser Arg Pro Thr Glu Arg Pro Arg 
1               5                   10                  15      


Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro Val Glu 
            20                  25                  30  


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  25

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


<210>  26
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  26

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  27

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  28

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  29

Phe Trp Arg Gly Asp Leu Val Phe Asp Phe Gln Val 
1               5                   10          


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  30

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro 
            20                  25  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  31

Ala Lys Arg Ala Arg Leu Ser Thr Ser Phe Asn Pro Val Tyr Pro Tyr 
1               5                   10                  15      


Glu Asp Glu Ser 
            20  


<210>  32
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  32

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  33

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  34

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  35

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  36

Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly 
1               5                   10                  15  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  37

Val Ala Tyr Ile Ser Arg Gly Gly Val Ser Thr Tyr Tyr Ser Asp Thr 
1               5                   10                  15      


Val Lys Gly Arg Phe Thr Arg Gln Lys Tyr Asn Lys Arg Ala 
            20                  25                  30  


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  38

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  39
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  39

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  40

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  O-alpha-(N-acetyl-galactosyl)-Thr

<400>  41

Val Asp Lys Gly Ser Tyr Leu Pro Arg Pro Xaa Pro Pro Arg Pro Ile 
1               5                   10                  15      


Tyr Asn Arg Asn 
            20  


<210>  42
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                 890                 895     


His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                 905                 910         


Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                 920                 925             


Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                 935                 940                 


Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                 950                 955                 960 


Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                 970                 975     


Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                 985                 990         


Ser Lys Pro Ser Glu Thr Gly Glu  Glu Gln Gly Leu Ile  Asn Ser Ser 
        995                 1000                 1005             


Val Thr  Lys Cys Phe Ser Ser  Lys Asn Ser Pro Leu  Lys Asp Ser 
    1010                 1015                 1020             


Phe Ser  Asn Ser Ser Trp Glu  Ile Glu Ala Gln Ala  Phe Phe Ile 
    1025                 1030                 1035             


Leu Ser  Asp Gln His Pro Asn  Ile Ile Ser Pro His  Leu Thr Phe 
    1040                 1045                 1050             


Ser Glu  Gly Leu Asp Glu Leu  Leu Lys Leu Glu Gly  Asn Phe Pro 
    1055                 1060                 1065             


Glu Glu  Asn Asn Asp Lys Lys  Ser Ile Tyr Tyr Leu  Gly Val Thr 
    1070                 1075                 1080             


Ser Ile  Lys Lys Arg Glu Ser  Gly Val Leu Leu Thr  Asp Lys Ser 
    1085                 1090                 1095             


Arg Val  Ser Cys Pro Phe Pro  Ala Pro Cys Leu Phe  Thr Asp Ile 
    1100                 1105                 1110             


Arg Val  Leu Gln Asp Ser Cys  Ser His Phe Val Glu  Asn Asn Ile 
    1115                 1120                 1125             


Asn Leu  Gly Thr Ser Ser Lys  Lys Thr Phe Ala Ser  Tyr Met Pro 
    1130                 1135                 1140             


Gln Phe  Gln Thr Cys Ser Thr  Gln Thr His Lys Ile  Met Glu Asn 
    1145                 1150                 1155             


Lys Met  Cys Asp Leu Thr Val  
    1160                 1165 


