                         SEQUENCE LISTING

<110>  Universittsklinikum Heidelberg
 
<120>  Gene signature for replicative senescence in cell cultures

<130>  UH66509EP

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  3786
<212>  DNA
<213>  Homo sapiens

<400>  1
atgattgctc acaaacagaa aaagacaaag aaaaaacgtg cttgggcatc aggtcaactc       60

tctactgata ttacaacttc tgaaatgggg ctcaagtcct taagttccaa ctctattttt      120

gatccggatt acatcaagga gttggtgaat gatatcagga agttctccca catgttacta      180

tatttgaaag aagccatatt ttcagactgt tttaaagaag ttattcatat acgtctagag      240

gaactgctcc gtgttttaaa gtctataatg aataaacatc agaacctcaa ttctgttgat      300

cttcaaaatg ctgcagaaat gctcactgca aaagtgaaag ctgtgaactt cacagaagtt      360

aatgaagaaa acaaaaacga tctcttccag gaagtgtttt cttctattga aactttggca      420

tttacctttg gaaatatcct tacaaacttc cttatgggag atgtaggcaa tgattcatta      480

ttgcgactgc ctgtttctcg agaaactaag tcgtttgaaa atgtttctgt ggaatcagtg      540

gactcatcca gtgaaaaagg aaatttttcc cctttagaac tagacaacgt gctgttaaag      600

aacactgact ctatcgagct ggctttgtca tatgctaaaa cttggtcaaa atatactaag      660

aacatagttt catgggttga aaaaaagctt aacttggaat tggagtccac tagaaatatg      720

gtcaagttgg cagaggcaac tagaactaac attggaattc aggagttcat gccactgcag      780

tctctgttta ctaatgctct tcttaatgat atagaaagca gtcacctttt acaacaaaca      840

attgcagctc tccaggctaa caaatttgtg cagcctctac ttggaaggaa aaatgaaatg      900

gaaaaacaaa ggaaagaaat aaaagagctt tggaaacagg agcaaaataa aatgcttgaa      960

gcagagaatg ctctcaaaaa ggcaaaatta ttatgcatgc aacgtcaaga tgaatatgag     1020

aaagcaaagt cttccatgtt tcgtgcagaa gaggagcatc tgtcttcaag tggcggatta     1080

gcaaaaaatc tcaacaagca actagaaaaa aagcgaaggt tggaagagga ggctctccaa     1140

aaagtagaag aagcaaatga actttacaaa gtttgtgtga caaatgttga agaaagaaga     1200

aatgatctag aaaataccaa aagagaaatt ttagcacaac tccggacact tgttttccag     1260

tgtgatctta cccttaaagc tgtaacagtt aacctcttcc acatgcagca tctgcaggct     1320

gcttcccttg cagacagttt acagtctctc tgtgatagtg ccaaactcta tgacccaggc     1380

caagagtaca gtgaatttgt caaggccaca aattcaactg aagaagaaaa agttgatgga     1440

aatgtaaata aacatttaaa tagttcccaa ccttcaggat ttggacctgc caactcttta     1500

gaggatgttg tacgccttcc tgacagttct aataaaattg aagaggacag atgctctaac     1560

agtgcagata taacaggtcc ttcctttata agatcatgga catttgggat gtttagtgat     1620

tctgagagca ctggagggag cagcgaatct agatctctgg attcagaatc tataagtcca     1680

ggagactttc atcgaaaact tccacgaaca ccatccagtg gaactatgtc ctctgcagat     1740

gatctagatg aaagagagcc accttcccct tcagaaactg gacccaattc ccttggaaca     1800

tttaagaaaa cattgatgtc aaaggcagct ctcacacaca agtttcgcaa attgagatcc     1860

cccacgaaat gtagggattg tgaaggcatt gtagtgttcc aaggtgttga atgtgaagag     1920

tgtctccttg tttgtcatcg aaagtgtttg gaaaatttag tcattatttg tggtcatcag     1980

aaacttccag gaaaaataca cttatttgga gcagaattca cacaagttgc aaaaaaggaa     2040

ccagatggta tcccttttat actcaaaata tgtgcctcag agattgaaaa tagagctttg     2100

tgtctacagg gaatttatcg tgtgtgtgga aacaaaataa aaactgaaaa attgtgtcaa     2160

gctttggaaa atggaatgca cttggtagat atttcagaat ttagttcaca tgatatctgt     2220

gacgtcttga aattatacct tcggcagctc ccagaaccat ttattttatt tcgattgtac     2280

aaggaattta tagaccttgc aaaagagatc caacatgtaa atgaagaaca agagacaaaa     2340

aagaatagtc ttgaagacaa aaaatggcca aatatgtgta tagaaataaa ccgaattctt     2400

ctaaaaagca aagaccttct aagacaattg ccagcatcaa attttaacag tcttcatttc     2460

cttatagtac atctaaagcg ggtagtagat catgcagaag aaaacaagat gaactccaaa     2520

aacttggggg tgatatttgg accaagtctc attaggccaa ggcccacaac tgctcctatc     2580

accatctcct cccttgcaga gtattcaaat caagcacgct tggtagagtt tctcattact     2640

tactcacaga agatcttcga tgggtcccta caaccacaag atgttatgtg tagcataggt     2700

gttgttgatc aaggctgttt tccaaagcct ctgttatcac cagaagaaag agacattgaa     2760

cgttccatga agtcactatt tttttcttca aaggaagata tccatacttc agagagtgaa     2820

agcaaaattt ttgaacgagc tacatcattt gaggaatcag aacgcaagca aaatgcgtta     2880

ggaaaatgtg atgcatgtct cagtgacaaa gcacagttgc ttctagacca agaggctgaa     2940

tcagcatccc aaaagataga agatggtaaa acccctaagc cactttctct gaaatctgat     3000

aggtcaacaa acaatgtgga gaggcatact ccaaggacca agattagacc tgtaagtttg     3060

cctgtagata gactacttct tgcaagtcct cctaatgaga gaaatggcag aaatatggga     3120

aatgtaaatt tagacaagtt ttgcaagaat cctgcctttg aaggagttaa tagaaaagac     3180

gctgctacta ctgtttgttc caaatttaat ggctttgacc agcaaactct acagaaaatt     3240

caggacaaac agtatgaaca aaacagccta actgccaaga ctacaatgat catgcccagt     3300

gcactccagg aaaaaggagt gacaacaagc ctccagatta gtggggacca ttctatcaat     3360

gccactcaac ccagtaagcc atatgcagag ccagtcaggt cagtgagaga ggcatctgag     3420

agacggtctt cagattccta ccctctcgct cctgtcagag cacccagaac actgcagcct     3480

caacattgga caacatttta taaaccacat gctcccatca tcagtatcag ggggaatgag     3540

gagaagccag cttcaccctc agcagcagtg cctcctggca cagatcacga tccccacggt     3600

ctcgtggtga agtcaatgcc agacccagac aaagcatcag cttgtcctgg gcaagcaact     3660

ggtcaaccta aagaagactc tgaggagctt ggcttgcctg atgtgaatcc aatgtgtcag     3720

agaccaaggc taaaacgaat gcaacagttt gaagacctcg aaggtgaaat tccacaattt     3780

gtgtag                                                                3786


<210>  2
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcgcgagg agaacaaggg catgcccagt gggggcggca gcgatgaggg tctggccagc       60

gccgcggcgc ggggactagt ggagaaggtg cgacagctcc tggaagccgg cgcggatccc      120

aacggagtca accgtttcgg gaggcgcgcg atccaggtca tgatgatggg cagcgcccgc      180

gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgcagaccc tgccactctc      240

acccgaccgg tgcatgatgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac      300

cgggccgggg cgcggctgga cgtgcgcgat gcctggggtc gtctgcccgt ggacttggcc      360

gaggagcggg gccaccgcga cgttgcaggg tacctgcgca cagccacggg ggactga         417


<210>  3
<211>  507
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcaggctc aacagtacca gcagcagcgt cgaaaatttg cagctgcctt cttggcattc       60

attttcatac tggcagctgt ggatactgct gaagcaggga agaaagagaa accagaaaaa      120

aaagtgaaga agtctgactg tggagaatgg cagtggagtg tgtgtgtgcc caccagtgga      180

gactgtgggc tgggcacacg ggagggcact cggactggag ctgagtgcaa gcaaaccatg      240

aagacccaga gatgtaagat cccctgcaac tggaagaagc aatttggcgc ggagtgcaaa      300

taccagttcc aggcctgggg agaatgtgac ctgaacacag ccctgaagac cagaactgga      360

agtctgaagc gagccctgca caatgccgaa tgccagaaga ctgtcaccat ctccaagccc      420

tgtggcaaac tgaccaagcc caaacctcaa gcagaatcta agaagaagaa aaaggaaggc      480

aagaaacagg agaagatgct ggattaa                                          507


<210>  4
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  4
atggcgggta ccgtggtgct ggacgatgtg gagctgcggg aggctcagag agattacctg       60

gacttcctgg acgacgagga agaccaggga atttatcaga gcaaagttcg ggagctgatc      120

agtgacaacc aataccggct gattgtcaat gtgaatgacc tgcgcaggaa aaacgagaag      180

agggctaacc ggcttctgaa caatgccttt gaggagctgg ttgccttcca gcgggcctta      240

aaggattttg tggcctccat tgatgctacc tatgccaagc agtatgagga gttctacgta      300

ggactggaag gcagctttgg ctccaagcac gtctccccgc ggactcttac ctcctgcttc      360

ctcagctgtg tggtctgtgt ggagggcatt gtcactaaat gttctctagt tcgtcccaaa      420

gtcgtccgca gtgtccacta ctgtcctgct actaagaaga ccatagagcg acgttattct      480

gatctcacca ccctggtggc ctttccctcc agctctgtct atcctaccaa ggatgaggag      540

aacaatcccc ttgagacaga atatggcctt tctgtctaca aggatcacca gaccatcacc      600

atccaggaga tgccggagaa ggccccagcc ggccagctcc cccgctctgt ggacgtcatt      660

ctggatgatg acttggtgga taaagcgaag cctggtgacc gggttcaggt ggtgggaacc      720

taccgttgcc ttcctggaaa gaagggaggc tacacctctg ggaccttcag gactgtcctg      780

attgcctgta atgttaagca gatgagcaag gatgctcagc cctctttctc tgctgaggat      840

atagccaaga tcaagaagtt cagtaaaacc cgatccaagg atatctttga ccagctggcc      900

aagtcattgg ccccaagtat ccatgggcat gactatgtca agaaagcaat cctctgcttg      960

ctcttgggag gggtggaacg agacctagaa aatggcagcc acatccgtgg ggacatcaat     1020

attcttctaa taggagaccc atccgttgcc aagtctcagc ttctgcggta tgtgctttgc     1080

actgcacccc gagctatccc caccactggc cggggctcct ctggagtggg tctgacggct     1140

gctgtcacca cagaccagga aacaggagag cgccgtctgg aagcaggggc catggtcctg     1200

gctgaccgag gcgtggtttg cattgatgaa tttgacaaaa tgtctgacat ggatcgcaca     1260

gccatccatg aagtgatgga gcagggtcga gtgaccattg ccaaggctgg catccatgct     1320

cggctgaatg cccgctgcag tgttttggca gctgccaacc ctgtctacgg caggtatgac     1380

cagtataaga ctccaatgga gaacattggg ctacaggact cactgctgtc acgatttgac     1440

ttgctcttca tcatgctgga tcagatggat cctgagcagg atcgggagat ctcagaccat     1500

gtccttcgga tgcaccgtta cagagcacct ggggagcagg atggcgatgc tatgcccttg     1560

ggtagtgctg tggatatcct ggccacagat gatcccaact ttagccagga agatcagcag     1620

gacacccaga tttatgagaa gcatgacaac cttctacatg ggaccaagaa gaaaaaggag     1680

aagatggtga gtgcagcatt catgaagaag tacatccatg tggccaaaat catcaagcct     1740

gtcctgacac aggagtcggc cacctacatt gcagaagagt attcacgcct gcgcagccag     1800

gatagcatga gctcagacac cgccaggaca tctccagtta cagcccgaac actggaaact     1860

ctgattcgac tggccacagc ccatgcgaag gcccgcatga gcaagactgt ggacctgcag     1920

gatgcagagg aagctgtgga gttggtccag tatgcttact ttaagaaggt tctggagaag     1980

gagaagaaac gtaagaagcg aagtgaggat gaatcagaga cagaagatga agaggagaaa     2040

agccaagagg accaggagca gaagaggaag agaaggaaga ctcgccagcc agatgccaaa     2100

gatggggatt catacgaccc ctatgacttc agtgacacag aggaggaaat gcctcaagta     2160

cacactccaa agacggcaga ctcacaggag accaaggaat cccagaaagt ggagttgagt     2220

gaatccaggt tgaaggcatt caaggtggcc ctcttggatg tgttccggga agctcatgcg     2280

cagtcaatcg gcatgaatcg cctcacagaa tccatcaacc gggacagcga agagcccttc     2340

tcttcagttg agatccaggc tgctctgagc aagatgcagg atgacaatca ggtcatggtg     2400

tctgagggca tcatcttcct catctga                                         2427


<210>  5
<211>  1261
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Ala His Lys Gln Lys Lys Thr Lys Lys Lys Arg Ala Trp Ala 
1               5                   10                  15      


Ser Gly Gln Leu Ser Thr Asp Ile Thr Thr Ser Glu Met Gly Leu Lys 
            20                  25                  30          


Ser Leu Ser Ser Asn Ser Ile Phe Asp Pro Asp Tyr Ile Lys Glu Leu 
        35                  40                  45              


Val Asn Asp Ile Arg Lys Phe Ser His Met Leu Leu Tyr Leu Lys Glu 
    50                  55                  60                  


Ala Ile Phe Ser Asp Cys Phe Lys Glu Val Ile His Ile Arg Leu Glu 
65                  70                  75                  80  


Glu Leu Leu Arg Val Leu Lys Ser Ile Met Asn Lys His Gln Asn Leu 
                85                  90                  95      


Asn Ser Val Asp Leu Gln Asn Ala Ala Glu Met Leu Thr Ala Lys Val 
            100                 105                 110         


Lys Ala Val Asn Phe Thr Glu Val Asn Glu Glu Asn Lys Asn Asp Leu 
        115                 120                 125             


Phe Gln Glu Val Phe Ser Ser Ile Glu Thr Leu Ala Phe Thr Phe Gly 
    130                 135                 140                 


Asn Ile Leu Thr Asn Phe Leu Met Gly Asp Val Gly Asn Asp Ser Leu 
145                 150                 155                 160 


Leu Arg Leu Pro Val Ser Arg Glu Thr Lys Ser Phe Glu Asn Val Ser 
                165                 170                 175     


Val Glu Ser Val Asp Ser Ser Ser Glu Lys Gly Asn Phe Ser Pro Leu 
            180                 185                 190         


Glu Leu Asp Asn Val Leu Leu Lys Asn Thr Asp Ser Ile Glu Leu Ala 
        195                 200                 205             


Leu Ser Tyr Ala Lys Thr Trp Ser Lys Tyr Thr Lys Asn Ile Val Ser 
    210                 215                 220                 


Trp Val Glu Lys Lys Leu Asn Leu Glu Leu Glu Ser Thr Arg Asn Met 
225                 230                 235                 240 


Val Lys Leu Ala Glu Ala Thr Arg Thr Asn Ile Gly Ile Gln Glu Phe 
                245                 250                 255     


Met Pro Leu Gln Ser Leu Phe Thr Asn Ala Leu Leu Asn Asp Ile Glu 
            260                 265                 270         


Ser Ser His Leu Leu Gln Gln Thr Ile Ala Ala Leu Gln Ala Asn Lys 
        275                 280                 285             


Phe Val Gln Pro Leu Leu Gly Arg Lys Asn Glu Met Glu Lys Gln Arg 
    290                 295                 300                 


Lys Glu Ile Lys Glu Leu Trp Lys Gln Glu Gln Asn Lys Met Leu Glu 
305                 310                 315                 320 


Ala Glu Asn Ala Leu Lys Lys Ala Lys Leu Leu Cys Met Gln Arg Gln 
                325                 330                 335     


Asp Glu Tyr Glu Lys Ala Lys Ser Ser Met Phe Arg Ala Glu Glu Glu 
            340                 345                 350         


His Leu Ser Ser Ser Gly Gly Leu Ala Lys Asn Leu Asn Lys Gln Leu 
        355                 360                 365             


Glu Lys Lys Arg Arg Leu Glu Glu Glu Ala Leu Gln Lys Val Glu Glu 
    370                 375                 380                 


Ala Asn Glu Leu Tyr Lys Val Cys Val Thr Asn Val Glu Glu Arg Arg 
385                 390                 395                 400 


Asn Asp Leu Glu Asn Thr Lys Arg Glu Ile Leu Ala Gln Leu Arg Thr 
                405                 410                 415     


Leu Val Phe Gln Cys Asp Leu Thr Leu Lys Ala Val Thr Val Asn Leu 
            420                 425                 430         


Phe His Met Gln His Leu Gln Ala Ala Ser Leu Ala Asp Ser Leu Gln 
        435                 440                 445             


Ser Leu Cys Asp Ser Ala Lys Leu Tyr Asp Pro Gly Gln Glu Tyr Ser 
    450                 455                 460                 


Glu Phe Val Lys Ala Thr Asn Ser Thr Glu Glu Glu Lys Val Asp Gly 
465                 470                 475                 480 


Asn Val Asn Lys His Leu Asn Ser Ser Gln Pro Ser Gly Phe Gly Pro 
                485                 490                 495     


Ala Asn Ser Leu Glu Asp Val Val Arg Leu Pro Asp Ser Ser Asn Lys 
            500                 505                 510         


Ile Glu Glu Asp Arg Cys Ser Asn Ser Ala Asp Ile Thr Gly Pro Ser 
        515                 520                 525             


Phe Ile Arg Ser Trp Thr Phe Gly Met Phe Ser Asp Ser Glu Ser Thr 
    530                 535                 540                 


Gly Gly Ser Ser Glu Ser Arg Ser Leu Asp Ser Glu Ser Ile Ser Pro 
545                 550                 555                 560 


Gly Asp Phe His Arg Lys Leu Pro Arg Thr Pro Ser Ser Gly Thr Met 
                565                 570                 575     


Ser Ser Ala Asp Asp Leu Asp Glu Arg Glu Pro Pro Ser Pro Ser Glu 
            580                 585                 590         


Thr Gly Pro Asn Ser Leu Gly Thr Phe Lys Lys Thr Leu Met Ser Lys 
        595                 600                 605             


Ala Ala Leu Thr His Lys Phe Arg Lys Leu Arg Ser Pro Thr Lys Cys 
    610                 615                 620                 


Arg Asp Cys Glu Gly Ile Val Val Phe Gln Gly Val Glu Cys Glu Glu 
625                 630                 635                 640 


Cys Leu Leu Val Cys His Arg Lys Cys Leu Glu Asn Leu Val Ile Ile 
                645                 650                 655     


Cys Gly His Gln Lys Leu Pro Gly Lys Ile His Leu Phe Gly Ala Glu 
            660                 665                 670         


Phe Thr Gln Val Ala Lys Lys Glu Pro Asp Gly Ile Pro Phe Ile Leu 
        675                 680                 685             


Lys Ile Cys Ala Ser Glu Ile Glu Asn Arg Ala Leu Cys Leu Gln Gly 
    690                 695                 700                 


Ile Tyr Arg Val Cys Gly Asn Lys Ile Lys Thr Glu Lys Leu Cys Gln 
705                 710                 715                 720 


Ala Leu Glu Asn Gly Met His Leu Val Asp Ile Ser Glu Phe Ser Ser 
                725                 730                 735     


His Asp Ile Cys Asp Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu 
            740                 745                 750         


Pro Phe Ile Leu Phe Arg Leu Tyr Lys Glu Phe Ile Asp Leu Ala Lys 
        755                 760                 765             


Glu Ile Gln His Val Asn Glu Glu Gln Glu Thr Lys Lys Asn Ser Leu 
    770                 775                 780                 


Glu Asp Lys Lys Trp Pro Asn Met Cys Ile Glu Ile Asn Arg Ile Leu 
785                 790                 795                 800 


Leu Lys Ser Lys Asp Leu Leu Arg Gln Leu Pro Ala Ser Asn Phe Asn 
                805                 810                 815     


Ser Leu His Phe Leu Ile Val His Leu Lys Arg Val Val Asp His Ala 
            820                 825                 830         


Glu Glu Asn Lys Met Asn Ser Lys Asn Leu Gly Val Ile Phe Gly Pro 
        835                 840                 845             


Ser Leu Ile Arg Pro Arg Pro Thr Thr Ala Pro Ile Thr Ile Ser Ser 
    850                 855                 860                 


Leu Ala Glu Tyr Ser Asn Gln Ala Arg Leu Val Glu Phe Leu Ile Thr 
865                 870                 875                 880 


Tyr Ser Gln Lys Ile Phe Asp Gly Ser Leu Gln Pro Gln Asp Val Met 
                885                 890                 895     


Cys Ser Ile Gly Val Val Asp Gln Gly Cys Phe Pro Lys Pro Leu Leu 
            900                 905                 910         


Ser Pro Glu Glu Arg Asp Ile Glu Arg Ser Met Lys Ser Leu Phe Phe 
        915                 920                 925             


Ser Ser Lys Glu Asp Ile His Thr Ser Glu Ser Glu Ser Lys Ile Phe 
    930                 935                 940                 


Glu Arg Ala Thr Ser Phe Glu Glu Ser Glu Arg Lys Gln Asn Ala Leu 
945                 950                 955                 960 


Gly Lys Cys Asp Ala Cys Leu Ser Asp Lys Ala Gln Leu Leu Leu Asp 
                965                 970                 975     


Gln Glu Ala Glu Ser Ala Ser Gln Lys Ile Glu Asp Gly Lys Thr Pro 
            980                 985                 990         


Lys Pro Leu Ser Leu Lys Ser Asp  Arg Ser Thr Asn Asn  Val Glu Arg 
        995                 1000                 1005             


His Thr  Pro Arg Thr Lys Ile  Arg Pro Val Ser Leu  Pro Val Asp 
    1010                 1015                 1020             


Arg Leu  Leu Leu Ala Ser Pro  Pro Asn Glu Arg Asn  Gly Arg Asn 
    1025                 1030                 1035             


Met Gly  Asn Val Asn Leu Asp  Lys Phe Cys Lys Asn  Pro Ala Phe 
    1040                 1045                 1050             


Glu Gly  Val Asn Arg Lys Asp  Ala Ala Thr Thr Val  Cys Ser Lys 
    1055                 1060                 1065             


Phe Asn  Gly Phe Asp Gln Gln  Thr Leu Gln Lys Ile  Gln Asp Lys 
    1070                 1075                 1080             


Gln Tyr  Glu Gln Asn Ser Leu  Thr Ala Lys Thr Thr  Met Ile Met 
    1085                 1090                 1095             


Pro Ser  Ala Leu Gln Glu Lys  Gly Val Thr Thr Ser  Leu Gln Ile 
    1100                 1105                 1110             


Ser Gly  Asp His Ser Ile Asn  Ala Thr Gln Pro Ser  Lys Pro Tyr 
    1115                 1120                 1125             


Ala Glu  Pro Val Arg Ser Val  Arg Glu Ala Ser Glu  Arg Arg Ser 
    1130                 1135                 1140             


Ser Asp  Ser Tyr Pro Leu Ala  Pro Val Arg Ala Pro  Arg Thr Leu 
    1145                 1150                 1155             


Gln Pro  Gln His Trp Thr Thr  Phe Tyr Lys Pro His  Ala Pro Ile 
    1160                 1165                 1170             


Ile Ser  Ile Arg Gly Asn Glu  Glu Lys Pro Ala Ser  Pro Ser Ala 
    1175                 1180                 1185             


Ala Val  Pro Pro Gly Thr Asp  His Asp Pro His Gly  Leu Val Val 
    1190                 1195                 1200             


Lys Ser  Met Pro Asp Pro Asp  Lys Ala Ser Ala Cys  Pro Gly Gln 
    1205                 1210                 1215             


Ala Thr  Gly Gln Pro Lys Glu  Asp Ser Glu Glu Leu  Gly Leu Pro 
    1220                 1225                 1230             


Asp Val  Asn Pro Met Cys Gln  Arg Pro Arg Leu Lys  Arg Met Gln 
    1235                 1240                 1245             


Gln Phe  Glu Asp Leu Glu Gly  Glu Ile Pro Gln Phe  Val 
    1250                 1255                 1260     


<210>  6
<211>  138
<212>  PRT
<213>  Homo spiens

<400>  6

Met Arg Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu 
1               5                   10                  15      


Gly Leu Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln 
            20                  25                  30          


Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg 
        35                  40                  45              


Arg Ala Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu 
    50                  55                  60                  


Leu Leu Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu 
65                  70                  75                  80  


Thr Arg Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu 
                85                  90                  95      


Val Val Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp 
            100                 105                 110         


Gly Arg Leu Pro Val Asp Leu Ala Glu Glu Arg Gly His Arg Asp Val 
        115                 120                 125             


Ala Gly Tyr Leu Arg Thr Ala Thr Gly Asp 
    130                 135             


<210>  7
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 
145                 150                 155                 160 


Lys Lys Gln Glu Lys Met Leu Asp 
                165             


<210>  8
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr 
            20                  25                  30          


Gln Ser Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile 
        35                  40                  45              


Val Asn Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg 
    50                  55                  60                  


Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu 
65                  70                  75                  80  


Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu 
                85                  90                  95      


Glu Phe Tyr Val Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser 
            100                 105                 110         


Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu 
        115                 120                 125             


Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser 
    130                 135                 140                 


Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser 
145                 150                 155                 160 


Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr 
                165                 170                 175     


Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val 
            180                 185                 190         


Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala 
        195                 200                 205             


Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp 
    210                 215                 220                 


Leu Val Asp Lys Ala Lys Pro Gly Asp Arg Val Gln Val Val Gly Thr 
225                 230                 235                 240 


Tyr Arg Cys Leu Pro Gly Lys Lys Gly Gly Tyr Thr Ser Gly Thr Phe 
                245                 250                 255     


Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ala 
            260                 265                 270         


Gln Pro Ser Phe Ser Ala Glu Asp Ile Ala Lys Ile Lys Lys Phe Ser 
        275                 280                 285             


Lys Thr Arg Ser Lys Asp Ile Phe Asp Gln Leu Ala Lys Ser Leu Ala 
    290                 295                 300                 


Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu 
305                 310                 315                 320 


Leu Leu Gly Gly Val Glu Arg Asp Leu Glu Asn Gly Ser His Ile Arg 
                325                 330                 335     


Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser 
            340                 345                 350         


Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr 
        355                 360                 365             


Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr 
    370                 375                 380                 


Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu 
385                 390                 395                 400 


Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp 
                405                 410                 415     


Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr 
            420                 425                 430         


Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val 
        435                 440                 445             


Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr 
    450                 455                 460                 


Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp 
465                 470                 475                 480 


Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu 
                485                 490                 495     


Ile Ser Asp His Val Leu Arg Met His Arg Tyr Arg Ala Pro Gly Glu 
            500                 505                 510         


Gln Asp Gly Asp Ala Met Pro Leu Gly Ser Ala Val Asp Ile Leu Ala 
        515                 520                 525             


Thr Asp Asp Pro Asn Phe Ser Gln Glu Asp Gln Gln Asp Thr Gln Ile 
    530                 535                 540                 


Tyr Glu Lys His Asp Asn Leu Leu His Gly Thr Lys Lys Lys Lys Glu 
545                 550                 555                 560 


Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys 
                565                 570                 575     


Ile Ile Lys Pro Val Leu Thr Gln Glu Ser Ala Thr Tyr Ile Ala Glu 
            580                 585                 590         


Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala 
        595                 600                 605             


Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu 
    610                 615                 620                 


Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln 
625                 630                 635                 640 


Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys 
                645                 650                 655     


Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Arg Ser Glu Asp Glu Ser 
            660                 665                 670         


Glu Thr Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Gln Glu Gln Lys 
        675                 680                 685             


Arg Lys Arg Arg Lys Thr Arg Gln Pro Asp Ala Lys Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Asp Pro Tyr Asp Phe Ser Asp Thr Glu Glu Glu Met Pro Gln Val 
705                 710                 715                 720 


His Thr Pro Lys Thr Ala Asp Ser Gln Glu Thr Lys Glu Ser Gln Lys 
                725                 730                 735     


Val Glu Leu Ser Glu Ser Arg Leu Lys Ala Phe Lys Val Ala Leu Leu 
            740                 745                 750         


Asp Val Phe Arg Glu Ala His Ala Gln Ser Ile Gly Met Asn Arg Leu 
        755                 760                 765             


Thr Glu Ser Ile Asn Arg Asp Ser Glu Glu Pro Phe Ser Ser Val Glu 
    770                 775                 780                 


Ile Gln Ala Ala Leu Ser Lys Met Gln Asp Asp Asn Gln Val Met Val 
785                 790                 795                 800 


Ser Glu Gly Ile Ile Phe Leu Ile 
                805             


<210>  9
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
ttcgtcatgg gtgtgaacca                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
ctgtggtcat gagtccttcc a                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
caatgatcat gcccagtgca                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
gatcgtgatc tgtgccagga                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
cccaactcca ccagatagca                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
gggatttccg catcctagca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
cagtgagtca tccgtccaga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
gccattctcc acagtcagac                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
acattgggct acaggactca                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
tgaatgctgc actcaccatc                                                   20


