                         SEQUENCE LISTING

<110>  Horowitz, Lawrence
 
<120>  Expression of Surrogate Light Chains

<130>  SLN-0018

<140>  60/220,878
<141>  2009-06-26

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Trp Ala Pro Val Leu Leu Met Leu Phe Val Tyr Cys Thr Gly 
1               5                   10                  15      


Cys Gly Pro Gln Pro Val Leu His Gln Pro Pro Ala Met Ser Ser Ala 
            20                  25                  30          


Leu Gly Thr Thr Ile Arg Leu Thr Cys Thr Leu Arg Asn Asp His Asp 
        35                  40                  45              


Ile Gly Val Tyr Ser Val Tyr Trp Tyr Gln Gln Arg Pro Gly His Pro 
    50                  55                  60                  


Pro Arg Phe Leu Leu Arg Tyr Phe Ser Gln Ser Asp Lys Ser Gln Gly 
65                  70                  75                  80  


Pro Gln Val Pro Pro Arg Phe Ser Gly Ser Lys Asp Val Ala Arg Asn 
                85                  90                  95      


Arg Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Met Gly Ala Arg Ser Ser Glu Lys Glu Glu Arg Glu 
        115                 120                 125             


Arg Glu Trp Glu Glu Glu Met Glu Pro Thr Ala Ala Arg Thr Arg Val 
    130                 135                 140                 


Pro 
145 


<210>  2
<211>  142
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Trp Thr Ser Val Leu Leu Met Leu Leu Ala His Leu Thr Gly 
1               5                   10                  15      


Cys Gly Pro Gln Pro Met Val His Gln Pro Pro Ser Ala Ser Ser Ser 
            20                  25                  30          


Leu Gly Ala Thr Ile Arg Leu Ser Cys Thr Leu Ser Asn Asp His Asn 
        35                  40                  45              


Ile Gly Ile Tyr Ser Ile Tyr Trp Tyr Gln Gln Arg Pro Gly His Pro 
    50                  55                  60                  


Pro Arg Phe Leu Leu Arg Tyr Phe Ser His Ser Asp Lys His Gln Gly 
65                  70                  75                  80  


Pro Asp Ile Pro Pro Arg Phe Ser Gly Ser Lys Asp Thr Ala Arg Asn 
                85                  90                  95      


Leu Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Val Gly Leu Arg Ser His Glu Lys Lys Arg Met Glu 
        115                 120                 125             


Arg Glu Trp Glu Gly Glu Lys Ser Tyr Thr Asp Leu Gly Ser 
    130                 135                 140         


<210>  3
<211>  171
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Trp Thr Ser Val Leu Leu Met Leu Leu Ala His Leu Thr Gly 
1               5                   10                  15      


Lys Gly Thr Leu Gly Val Gln Gly Phe Leu Ala Pro Pro Val Ala Leu 
            20                  25                  30          


Leu Cys Pro Ser Asp Gly His Ala Ser Ile Phe Ser Gly Cys Gly Pro 
        35                  40                  45              


Gln Pro Met Val His Gln Pro Pro Ser Ala Ser Ser Ser Leu Gly Ala 
    50                  55                  60                  


Thr Ile Arg Leu Ser Cys Thr Leu Ser Asn Asp His Asn Ile Gly Ile 
65                  70                  75                  80  


Tyr Ser Ile Tyr Trp Tyr Gln Gln Arg Pro Gly His Pro Pro Arg Phe 
                85                  90                  95      


Leu Leu Arg Tyr Phe Ser His Ser Asp Lys His Gln Gly Pro Asp Ile 
            100                 105                 110         


Pro Pro Arg Phe Ser Gly Ser Lys Asp Thr Ala Arg Asn Leu Gly Tyr 
        115                 120                 125             


Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys 
    130                 135                 140                 


Ala Val Gly Leu Arg Ser His Glu Lys Lys Arg Met Glu Arg Glu Trp 
145                 150                 155                 160 


Glu Gly Glu Lys Ser Tyr Thr Asp Leu Gly Ser 
                165                 170     


<210>  4
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Cys Arg Cys Leu Ser Phe Leu Leu Met Gly Thr Phe Leu Ser 
1               5                   10                  15      


Val Ser Gln Thr Val Leu Ala Gln Leu Asp Ala Leu Leu Val Phe Pro 
            20                  25                  30          


Gly Gln Val Ala Gln Leu Ser Cys Thr Leu Ser Pro Gln His Val Thr 
        35                  40                  45              


Ile Arg Asp Tyr Gly Val Ser Trp Tyr Gln Gln Arg Ala Gly Ser Ala 
    50                  55                  60                  


Pro Arg Tyr Leu Leu Tyr Tyr Arg Ser Glu Glu Asp His His Arg Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Arg Phe Ser Ala Ala Lys Asp Glu Ala His Asn 
                85                  90                  95      


Ala Cys Val Leu Thr Ile Ser Pro Val Gln Pro Glu Asp Asp Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Ser Val Gly Tyr Gly Phe Ser Pro 
        115                 120             


<210>  5
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Trp Ala Pro Val Leu Leu Met Leu Phe Val Tyr Cys Thr Gly 
1               5                   10                  15      


Cys Gly Pro Gln Pro Val Leu His Gln Pro Pro Ala Met Ser Ser Ala 
            20                  25                  30          


Leu Gly Thr Thr Ile Arg Leu Thr Cys Thr Leu Arg Asn Asp His Asp 
        35                  40                  45              


Ile Gly Val Tyr Ser Val Tyr Trp Tyr Gln Gln Arg Pro Gly His Pro 
    50                  55                  60                  


Pro Arg Phe Leu Leu Arg Tyr Phe Ser Gln Ser Asp Lys Ser Gln Gly 
65                  70                  75                  80  


Pro Gln Val Pro Pro Arg Phe Ser Gly Ser Lys Asp Val Ala Arg Asn 
                85                  90                  95      


Arg Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Met Gly Ala 
        115                 


<210>  6
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Pro Val Leu His Gln Pro Pro Ala Met Ser Ser 
            20                  25                  30          


Ala Leu Gly Thr Thr Ile Arg Leu Thr Cys Thr Leu Arg Asn Asp His 
        35                  40                  45              


Asp Ile Gly Val Tyr Ser Val Tyr Trp Tyr Gln Gln Arg Pro Gly His 
    50                  55                  60                  


Pro Pro Arg Phe Leu Leu Arg Tyr Phe Ser Gln Ser Asp Lys Ser Gln 
65                  70                  75                  80  


Gly Pro Gln Val Pro Pro Arg Phe Ser Gly Ser Lys Asp Val Ala Arg 
                85                  90                  95      


Asn Arg Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Met Gly Ala Arg Ser Ser Glu Lys Glu Glu Arg 
        115                 120                 125             


Glu Arg Glu Trp Glu Glu Glu Met Glu Pro Thr Ala Ala Arg Thr Arg 
    130                 135                 140                 


Val Pro 
145     


<210>  7
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Leu Arg Val Gly Gln Thr Leu Gly Thr Ile Pro Arg Gln Cys 
1               5                   10                  15      


Glu Val Leu Leu Leu Leu Leu Leu Leu Gly Leu Val Asp Gly Val His 
            20                  25                  30          


His Ile Leu Ser Pro Ser Ser Ala Glu Arg Ser Arg Ala Val Gly Pro 
        35                  40                  45              


Gly Ala Ser Val Gly Ser Asn Arg Pro Ser Leu Trp Ala Leu Pro Gly 
    50                  55                  60                  


Arg Leu Leu Phe Gln Ile Ile Pro Arg Gly Ala Gly Pro Arg Cys Ser 
65                  70                  75                  80  


Pro His Arg Leu Pro Ser Lys Pro Gln Phe Trp Tyr Val Phe Gly Gly 
                85                  90                  95      


Gly Thr Gln Leu Thr Ile Leu Gly Gln Pro Lys Ser Asp Pro Leu Val 
            100                 105                 110         


Thr Leu Phe Leu Pro Ser Leu Lys Asn Leu Gln Pro Thr Arg Pro His 
        115                 120                 125             


Val Val Cys Leu Val Ser Glu Phe Tyr Pro Gly Thr Leu Val Val Asp 
    130                 135                 140                 


Trp Lys Val Asp Gly Val Pro Val Thr Gln Gly Val Glu Thr Thr Gln 
145                 150                 155                 160 


Pro Ser Lys Gln Thr Asn Asn Lys Tyr Met Val Ser Ser Tyr Leu Thr 
                165                 170                 175     


Leu Ile Ser Asp Gln Trp Met Pro His Ser Arg Tyr Ser Cys Arg Val 
            180                 185                 190         


Thr His Glu Gly Asn Thr Val Glu Lys Ser Val Ser Pro Ala Glu Cys 
        195                 200                 205             


Ser 
    


<210>  8
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Gly Thr Gly Gln Gly Gly Leu Glu Ala Pro Gly Glu Pro 
1               5                   10                  15      


Gly Pro Asn Leu Arg Gln Arg Trp Pro Leu Leu Leu Leu Gly Leu Ala 
            20                  25                  30          


Val Val Thr His Gly Leu Leu Arg Pro Thr Ala Ala Ser Gln Ser Arg 
        35                  40                  45              


Ala Leu Gly Pro Gly Ala Pro Gly Gly Ser Ser Arg Ser Ser Leu Arg 
    50                  55                  60                  


Ser Arg Trp Gly Arg Phe Leu Leu Gln Arg Gly Ser Trp Thr Gly Pro 
65                  70                  75                  80  


Arg Cys Trp Pro Arg Gly Phe Gln Ser Lys His Asn Ser Val Thr His 
                85                  90                  95      


Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gln Pro Lys Ala 
            100                 105                 110         


Thr Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Met Asn Asp Phe Tyr Pro Gly Ile 
    130                 135                 140                 


Leu Thr Val Thr Trp Lys Ala Asp Gly Thr Pro Ile Thr Gln Gly Val 
145                 150                 155                 160 


Glu Met Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Arg Ser Arg Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Met His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Ala Glu Cys Ser 
    210             


<210>  9
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Pro Gly Thr Gly Gln Gly Gly Leu Glu Ala Pro Gly Glu Pro 
1               5                   10                  15      


Gly Pro Asn Leu Arg Gln Arg Trp Pro Leu Leu Leu Leu Gly Leu Ala 
            20                  25                  30          


Val Val Thr His Gly Ser Val Thr His Val Phe Gly Ser Gly Thr Gln 
        35                  40                  45              


Leu Thr Val Leu Ser Gln Pro Lys Ala Thr Pro Ser Val Thr Leu Phe 
    50                  55                  60                  


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
65                  70                  75                  80  


Leu Met Asn Asp Phe Tyr Pro Gly Ile Leu Thr Val Thr Trp Lys Ala 
                85                  90                  95      


Asp Gly Thr Pro Ile Thr Gln Gly Val Glu Met Thr Thr Pro Ser Lys 
            100                 105                 110         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        115                 120                 125             


Glu Gln Trp Arg Ser Arg Arg Ser Tyr Ser Cys Gln Val Met His Glu 
    130                 135                 140                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
145                 150                 155             


<210>  10
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Val Thr His Val Phe Gly Ser Gly Thr Gln Leu 
            20                  25                  30          


Thr Val Leu Ser Gln Pro Lys Ala Thr Pro Ser Val Thr Leu Phe Pro 
        35                  40                  45              


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    50                  55                  60                  


Met Asn Asp Phe Tyr Pro Gly Ile Leu Thr Val Thr Trp Lys Ala Asp 
65                  70                  75                  80  


Gly Thr Pro Ile Thr Gln Gly Val Glu Met Thr Thr Pro Ser Lys Gln 
                85                  90                  95      


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            100                 105                 110         


Gln Trp Arg Ser Arg Arg Ser Tyr Ser Cys Gln Val Met His Glu Gly 
        115                 120                 125             


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
    130                 135                 140     


<210>  11
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  11
cagcaagatg gtgttgcaga cccaggtctt catttctctg ttgctctgga tctctggtgc       60

ctacggggac atcgtgatga cccagtctcc agactccctg gctgtgtctc tgggcgagag      120

ggccaccatc aactgcaagt ccagccagag tgttttatac agctccaaca ataagaacta      180

cttagcttgg taccagcaga aaccaggaca gcctcctaag ctgctcattt actgggcatc      240

tacccgggaa tccggggtcc ctgaccgatt cagtggcagc gggtctggga cagatttcac      300

tctcaccatc agcagcctgc aggctgaaga tgtggcagtt tattactgtc agcaatatta      360

tagtactcct cccacagtgc ttcagcctcg aacacaaacc tcctccccat acgctgggcc      420

agtaggtctt tgctgcagca gctgcttcct ctgcacacag cccccaacat gcatgcttcc      480

tctgtgtgtt ggggaggtca ctctcttgat ttattcgttg gagggtttgc agggcccagg      540

attaaattaa gagacttgac ttttgctgga tctctttttg tagaagatta ttaaagcaaa      600

atgttgtaaa gatcccttag agacattgtc aggagttttt gtgttacagg aacctgcatg      660

tttcacatgg acacatcaca tgaccgagcc aaatagattt atctttactc t               711


<210>  12
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Val Leu Gln Pro Arg 
        115                 120                 125             


Thr Gln Thr Ser Ser Pro Tyr Ala Gly Pro Val Gly Leu Cys Cys Ser 
    130                 135                 140                 


Ser Cys Phe Leu Cys Thr Gln Pro Pro Thr Cys Met Leu Pro Leu Cys 
145                 150                 155                 160 


Val Gly Glu Val Thr Leu Leu Ile Tyr Ser Leu Glu Gly Leu Gln Gly 
                165                 170                 175     


Pro Gly Leu Asn 
            180 


<210>  13
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Thr Val Leu Pro Thr Arg Thr 
            100             


<210>  14
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Val Leu His Thr Gln Thr 
            100             


<210>  15
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Val Leu His Thr Arg Thr Thr Pro Arg Glu Ala Asp Val 
            100                 105                 110 


<210>  16
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Thr Val 
        


<210>  17
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ile Gln Met Ile Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Trp Ala Ser Glu Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Lys Ser Pro Lys Leu Phe Leu 
        35                  40                  45              


Tyr Asp Ala Lys Asp Leu His Pro Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ile Ser Leu Lys Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ala Tyr Tyr Cys Lys Gln Asp Phe Ser Tyr Pro Pro 
                85                  90                  95      


Thr Gly Leu Gln Ala 
            100     


<210>  18
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Thr Val Val Gln Pro Leu Thr Glu Thr Ser Ser 
            100                 105                 110         


Trp Gly Cys Pro Val Ala His Met Cys Cys Leu Ser Gly Glu Gln Leu 
        115                 120                 125             


Ser Arg Val Ser Glu Ser Ala 
    130                 135 


<210>  19
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Val Val Gln Pro 
            100                 105     


<210>  20
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Val Ile Pro His Glu Thr Lys Thr Pro Thr Arg Pro Ser Val Phe 
            100                 105                 110         


Thr Arg Leu Leu Tyr Gln Leu Leu Pro Leu Gln Thr Ala Ser Gly Val 
        115                 120                 125             


Ala Thr Gln Cys 
    130         


<210>  21
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp His Pro 
                85                  90                  95      


Thr Val Ile Pro His Glu Thr Lys Thr Pro Thr Arg Pro Ser Val Phe 
            100                 105                 110         


Thr Arg Leu Leu Tyr Gln 
        115             


<210>  22
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 
        35                  40                  45              


Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln His Asp Asn Phe Pro Leu 
                85                  90                  95      


Thr Val Ile His Pro Val Gln Lys Pro Pro Ser Ser Leu Ser Gly Ile 
            100                 105                 110         


Ala Ser Ala 
        115 


<210>  23
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Val Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Gln Ala Ser Glu Gly Ile Gly Asn Tyr 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Lys His Pro His 
                85                  90                  95      


Thr Val Leu Gln Pro Lys Thr Lys Ile Ser Ser Ala Trp Arg Asn Arg 
            100                 105                 110         


Glu Thr Glu Gln Tyr Pro Val Phe Met Ile Leu Ala Gly Ala Val Gly 
        115                 120                 125             


Glu Ile Ile Tyr Gln Ile Pro Ser His Met Ala His Ser Ala Glu Leu 
    130                 135                 140                 


Thr Pro Lys Ser Gln Cys Leu Thr Leu Ser Ser Leu Pro Thr 
145                 150                 155             


<210>  24
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Phe Leu 
            20                  25                  30          


Gly Ile Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gln Ala Ser Asn Lys Asp Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Leu Gln Ser Lys 
                85                  90                  95      


Asn Phe Pro Pro Thr Val Leu 
            100             


<210>  25
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  25
gtgagaaggg tttttgttca gcaagacaat ggagagctca cactgtggtg gacgttcggc       60

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      120

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      180

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      240

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      300

acgctgagca aagcagacta cgagaaacac aaactctacg cctgcgaagt cacccatcag      360

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   408


<210>  26
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Arg Arg Val Phe Val Gln Gln Asp Asn Gly Glu Leu Thr Leu Trp 
1               5                   10                  15      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            20                  25                  30          


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        35                  40                  45              


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    50                  55                  60                  


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
65                  70                  75                  80  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                85                  90                  95      


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
            100                 105                 110         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        115                 120                 125             


Ser Phe Asn Arg Gly Glu Cys 
    130                 135 


<210>  27
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  27

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
1               5                   10                  15      


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            20                  25                  30          


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        35                  40                  45              


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    50                  55                  60                  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
65                  70                  75                  80  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
                85                  90                  95      


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            100                 105                 110         


Ser Phe Asn Arg Gly Glu Cys 
        115                 


<210>  28
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
1               5                   10                  15      


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            20                  25                  30          


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        35                  40                  45              


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    50                  55                  60                  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
65                  70                  75                  80  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
                85                  90                  95      


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            100                 105                 110         


Ser Phe Asn Arg Gly Glu Cys 
        115                 


<210>  29
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
1               5                   10                  15      


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            20                  25                  30          


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        35                  40                  45              


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    50                  55                  60                  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
65                  70                  75                  80  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
                85                  90                  95      


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            100                 105                 110         


Ser Phe Asn Arg Gly Glu Cys 
        115                 


<210>  30
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
1               5                   10                  15      


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            20                  25                  30          


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        35                  40                  45              


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    50                  55                  60                  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
65                  70                  75                  80  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
                85                  90                  95      


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            100                 105                 110         


Ser Phe Asn Arg Gly Glu Cys 
        115                 


<210>  31
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
1               5                   10                  15      


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            20                  25                  30          


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        35                  40                  45              


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    50                  55                  60                  


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
65                  70                  75                  80  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
                85                  90                  95      


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            100                 105                 110         


Ser Phe Asn Arg Gly Glu Cys 
        115                 


<210>  32
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Arg Arg Val Phe Val Gln Gln Asp Asn Gly Glu 
            20                  25                  30          


Leu Thr Leu Trp Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        35                  40                  45              


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    50                  55                  60                  


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
65                  70                  75                  80  


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                85                  90                  95      


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            100                 105                 110         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        115                 120                 125             


His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    130                 135                 140                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150                 


<210>  33
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            20                  25                  30          


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        35                  40                  45              


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    50                  55                  60                  


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
65                  70                  75                  80  


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                85                  90                  95      


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            100                 105                 110         


His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        115                 120                 125             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    130                 135             


<210>  34
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            20                  25                  30          


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        35                  40                  45              


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    50                  55                  60                  


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Gly Asn Ser Gln Glu Ser 
65                  70                  75                  80  


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                85                  90                  95      


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr Ala Cys 
            100                 105                 110         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        115                 120                 125             


Arg Gly Glu Cys 
    130         


<210>  35
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Pro Val Leu His Gln Pro Pro Ala Met Ser Ser 
            20                  25                  30          


Ala Leu Gly Thr Thr Ile Arg Leu Thr Cys Thr Leu Arg Asn Asp His 
        35                  40                  45              


Asp Ile Gly Val Tyr Ser Val Tyr Trp Tyr Gln Gln Arg Pro Gly His 
    50                  55                  60                  


Pro Pro Arg Phe Leu Leu Arg Tyr Phe Ser Gln Ser Asp Lys Ser Gln 
65                  70                  75                  80  


Gly Pro Gln Val Pro Pro Arg Phe Ser Gly Ser Lys Asp Val Ala Arg 
                85                  90                  95      


Asn Arg Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Met Gly Ala Arg Ser Ser Val Thr His Val Phe 
        115                 120                 125             


Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gln Pro Lys Ala Thr Pro 
    130                 135                 140                 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Met Asn Asp Phe Tyr Pro Gly Ile Leu Thr 
                165                 170                 175     


Val Thr Trp Lys Ala Asp Gly Thr Pro Ile Thr Gln Gly Val Glu Met 
            180                 185                 190         


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
        195                 200                 205             


Leu Ser Leu Thr Pro Glu Gln Trp Arg Ser Arg Arg Ser Tyr Ser Cys 
    210                 215                 220                 


Gln Val Met His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala 
225                 230                 235                 240 


Glu Cys Ser 
            


<210>  36
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


