                         SEQUENCE LISTING

<110>  Alexion Pharmaceuticals, Inc.
 
<120>  Bispecific Antibodies that Bind to Complement Proteins

<130>  ALXN-149-WO1

<140>  To be determined
<141>  Concurrently Herewith

<150>  61/219,644
<151>  2009-06-23

<150>  61/228,001
<151>  2009-07-23

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg 
65                  70                  


<210>  2
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala Ala Arg 
            20  





<210>  3
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu 
1               5                   10                  15      


Gln Arg 
        


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10  


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Asn Asn Asp Glu Thr 
1               5       


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ala Arg Ile Ser Leu Gly Pro Arg 
1               5                   











<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala Ala 
            


<210>  8
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg Ala 
        


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      


Arg 
    


<210>  10
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln 
1               5                   10                  15      



<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu 
1               5                   10                  15  


<210>  12
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10                  15      


Ala Ala Arg 
            


<210>  13
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala 
1               5                   10                  15      


Ala Arg 
        


<210>  14
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu Thr Cys Glu Gln Arg 
1               5                   10                  15      


Ala Ala Arg 
            



<210>  15
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg Val Gly 
1               5                   10                  15      


Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu Ala Phe 
            20                  25                  30          


Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe Ser Tyr 
        35                  40                  45              


Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln Asn Ser 
    50                  55                  60                  


Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln Asn Pro 
65                  70                  75                  80  


Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser Lys Ser 
                85                  90                  95      


Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile His Thr 
            100                 105                 110         


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg Val Tyr 
        115                 120                 125             


Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val Leu Thr 
    130                 135                 140                 


Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu Ile Asp 
145                 150                 155                 160 


His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser Asn Pro 
                165                 170                 175     


Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp Phe Ser 
            180                 185                 190         


Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu Pro His 
        195                 200                 205             


Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr Lys Asn 
    210                 215                 220                 


Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr Asn Lys 
225                 230                 235                 240 


Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg Glu Asp 
                245                 250                 255     


Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln Asn Thr 
            260                 265                 270         


Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu Thr Ala 
        275                 280                 285             


Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe Ser Glu 
305                 310                 315                 320 


Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr Lys Leu 
                325                 330                 335     


Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro Tyr Pro 
            340                 345                 350         


Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly Gly Val 
        355                 360                 365             


Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu Thr Ser 
    370                 375                 380                 


Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly Val Ala 
385                 390                 395                 400 


Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu Phe Asn 
                405                 410                 415     


Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu 
            420                 425                 430         


Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr Leu Tyr 
        435                 440                 445             


Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu His Leu 
    450                 455                 460                 


Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile Thr His 
465                 470                 475                 480 


Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe Gly Thr 
                485                 490                 495     


Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile Pro Val 
            500                 505                 510         


Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr Ile Val 
        515                 520                 525             


Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp Leu Asn 
    530                 535                 540                 


Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser Pro Asp 
545                 550                 555                 560 


Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met Ala Thr 
                565                 570                 575     


Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala Val Tyr 
            580                 585                 590         


Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe Gln Phe 
        595                 600                 605             


Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
    610                 615                 620                 


Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn Ala Asn 
625                 630                 635                 640 


Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile Leu 
                645                 650                 655 


<210>  16
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  16

Leu His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser 
1               5                   10                  15      


Tyr Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg 
            20                  25                  30          


Lys Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile 
        35                  40                  45              


Gln Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val 
    50                  55                  60                  


Lys Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr 
65                  70                  75                  80  


Ser Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn 
                85                  90                  95      


Tyr Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu 
            100                 105                 110         


Gly Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys 
        115                 120                 125             


Ser Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu 
    130                 135                 140                 


Val Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn 
145                 150                 155                 160 


Phe Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu 
                165                 170                 175     


Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr 
            180                 185                 190         


Leu Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe 
        195                 200                 205             


Pro Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg 
    210                 215                 220                 


Ile Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val 
225                 230                 235                 240 


Leu Ser Gln Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser 
                245                 250                 255     


Ala Glu Ala Glu Leu Met Ser Val Val Pro Val Phe Tyr Val Phe His 
            260                 265                 270         


Tyr Leu Glu Thr Gly Asn His Trp Asn Ile Phe His Ser Asp Pro Leu 
        275                 280                 285             


Ile Glu Lys Gln Lys Leu Lys Lys Lys Leu Lys Glu Gly Met Leu Ser 
    290                 295                 300                 


Ile Met Ser Tyr Arg Asn Ala Asp Tyr Ser Tyr Ser Val Trp Lys Gly 
305                 310                 315                 320 


Gly Ser Ala Ser Thr Trp Leu Thr Ala Phe Ala Leu Arg Val Leu Gly 
                325                 330                 335     


Gln Val Asn Lys Tyr Val Glu Gln Asn Gln Asn Ser Ile Cys Asn Ser 
            340                 345                 350         


Leu Leu Trp Leu Val Glu Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys 
        355                 360                 365             


Glu Asn Ser Gln Tyr Gln Pro Ile Lys Leu Gln Gly Thr Leu Pro Val 
    370                 375                 380                 


Glu Ala Arg Glu Asn Ser Leu Tyr Leu Thr Ala Phe Thr Val Ile Gly 
385                 390                 395                 400 


Ile Arg Lys Ala Phe Asp Ile Cys Pro Leu Val Lys Ile Asp Thr Ala 
                405                 410                 415     


Leu Ile Lys Ala Asp Asn Phe Leu Leu Glu Asn Thr Leu Pro Ala Gln 
            420                 425                 430         


Ser Thr Phe Thr Leu Ala Ile Ser Ala Tyr Ala Leu Ser Leu Gly Asp 
        435                 440                 445             


Lys Thr His Pro Gln Phe Arg Ser Ile Val Ser Ala Leu Lys Arg Glu 
    450                 455                 460                 


Ala Leu Val Lys Gly Asn Pro Pro Ile Tyr Arg Phe Trp Lys Asp Asn 
465                 470                 475                 480 


Leu Gln His Lys Asp Ser Ser Val Pro Asn Thr Gly Thr Ala Arg Met 
                485                 490                 495     


Val Glu Thr Thr Ala Tyr Ala Leu Leu Thr Ser Leu Asn Leu Lys Asp 
            500                 505                 510         


Ile Asn Tyr Val Asn Pro Val Ile Lys Trp Leu Ser Glu Glu Gln Arg 
        515                 520                 525             


Tyr Gly Gly Gly Phe Tyr Ser Thr Gln Asp Thr Ile Asn Ala Ile Glu 
    530                 535                 540                 


Gly Leu Thr Glu Tyr Ser Leu Leu Val Lys Gln Leu Arg Leu Ser Met 
545                 550                 555                 560 


Asp Ile Asp Val Ser Tyr Lys His Lys Gly Ala Leu His Asn Tyr Lys 
                565                 570                 575     


Met Thr Asp Lys Asn Phe Leu Gly Arg Pro Val Glu Val Leu Leu Asn 
            580                 585                 590         


Asp Asp Leu Ile Val Ser Thr Gly Phe Gly Ser Gly Leu Ala Thr Val 
        595                 600                 605             


His Val Thr Thr Val Val His Lys Thr Ser Thr Ser Glu Glu Val Cys 
    610                 615                 620                 


Ser Phe Tyr Leu Lys Ile Asp Thr Gln Asp Ile Glu Ala Ser His Tyr 
625                 630                 635                 640 


Arg Gly Tyr Gly Asn Ser Asp Tyr Lys Arg Ile Val Ala Cys Ala Ser 
                645                 650                 655     


Tyr Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly Ser Ser His Ala Val 
            660                 665                 670         


Met Asp Ile Ser Leu Pro Thr Gly Ile Ser Ala Asn Glu Glu Asp Leu 
        675                 680                 685             


Lys Ala Leu Val Glu Gly Val Asp Gln Leu Phe Thr Asp Tyr Gln Ile 
    690                 695                 700                 


Lys Asp Gly His Val Ile Leu Gln Leu Asn Ser Ile Pro Ser Ser Asp 
705                 710                 715                 720 


Phe Leu Cys Val Arg Phe Arg Ile Phe Glu Leu Phe Glu Val Gly Phe 
                725                 730                 735     


Leu Ser Pro Ala Thr Phe Thr Val Tyr Glu Tyr His Arg Pro Asp Lys 
            740                 745                 750         


Gln Cys Thr Met Phe Tyr Ser Thr Ser Asn Ile Lys Ile Gln Lys Val 
        755                 760                 765             


Cys Glu Gly Ala Ala Cys Lys Cys Val Glu Ala Asp Cys Gly Gln Met 
    770                 775                 780                 


Gln Glu Glu Leu Asp Leu Thr Ile Ser Ala Glu Thr Arg Lys Gln Thr 
785                 790                 795                 800 


Ala Cys Lys Pro Glu Ile Ala Tyr Ala Tyr Lys Val Ser Ile Thr Ser 
                805                 810                 815     


Ile Thr Val Glu Asn Val Phe Val Lys Tyr Lys Ala Thr Leu Leu Asp 
            820                 825                 830         


Ile Tyr Lys Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile Thr 
        835                 840                 845             


Phe Ile Lys Lys Val Thr Cys Thr Asn Ala Glu Leu Val Lys Gly Arg 
    850                 855                 860                 


Gln Tyr Leu Ile Met Gly Lys Glu Ala Leu Gln Ile Lys Tyr Asn Phe 
865                 870                 875                 880 



Ser Phe Arg Tyr Ile Tyr Pro Leu Asp Ser Leu Thr Trp Ile Glu Tyr 
                885                 890                 895     


Trp Pro Arg Asp Thr Thr Cys Ser Ser Cys Gln Ala Phe Leu Ala Asn 
            900                 905                 910         


Leu Asp Glu Phe Ala Glu Asp Ile Phe Leu Asn Gly Cys 
        915                 920                 925 


<210>  17
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr Ser Asn Thr 
            20                  25                  30          


Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe 
        35                  40                  45              


Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Thr Ala Phe 
    50                  55                  60                  


Glu Ala Lys Arg Thr Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val 
65                  70                  75                  80  


Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Thr Ser Ile 
                85                  90                  95      


Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu 
            100                 105                 110         


Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala 
        115                 120                 125             


Thr Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys 
    130                 135                 140                 


Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala 
145                 150                 155                 160 


Trp Gly Leu Ala Leu Leu Leu Thr Ile Pro Ser Phe Leu Tyr Arg Val 
                165                 170                 175     


Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr 
            180                 185                 190         


Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val 
        195                 200                 205             


Leu Gly Phe Leu Trp Pro Leu Leu Thr Leu Thr Ile Cys Tyr Thr Phe 
    210                 215                 220                 


Ile Leu Leu Arg Thr Trp Ser Arg Arg Ala Thr Arg Ser Thr Lys Thr 
225                 230                 235                 240 


Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu 
                245                 250                 255     


Pro Tyr Gln Val Thr Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser 
            260                 265                 270         


Pro Thr Phe Leu Leu Leu Asn Lys Leu Asp Ser Leu Cys Val Ser Phe 
        275                 280                 285             


Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly 
    290                 295                 300                 


Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg 
305                 310                 315                 320 


Asn Val Leu Thr Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Thr 
                325                 330                 335     


Arg Ser Thr Val Asp Thr Met Ala Gln Lys Thr Gln Ala Val 
            340                 345                 350 









<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Ile Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser 
1               5                   10                  15      


<210>  19
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Val Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val 
1               5                   10                  15      


Asp Tyr Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg 
            20                  25                  30          


<210>  20
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Phe Leu Glu Pro Ser Ser Pro Thr Phe Leu Leu Leu Asn Lys 
1               5                   10                  15      


Leu Asp Ser 
            


<210>  21
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr 
            20                  25                  



<210>  22
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Tyr Gly His Tyr Asp Asp Lys Asp Thr Leu Asp Leu Asn Thr Pro 
1               5                   10                  15      


Val Asp Lys Thr 
            20  


<210>  23
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg Val Ala Pro Leu Pro Leu Tyr Ala Ala Ile Phe Leu Val 
        35                  40                  45              


Gly Val Pro Gly Asn Ala Met Val Ala Trp Val Ala Gly Lys Val Ala 
    50                  55                  60                  


Arg Arg Arg Val Gly Ala Thr Trp Leu Leu His Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Cys Cys Leu Ser Leu Pro Ile Leu Ala Val Pro Ile Ala Arg 
                85                  90                  95      


Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg Ala Leu Pro Ser 
            100                 105                 110         


Ile Ile Leu Leu Thr Met Tyr Ala Ser Val Leu Leu Leu Ala Ala Leu 
        115                 120                 125             


Ser Ala Asp Leu Cys Phe Leu Ala Leu Gly Pro Ala Trp Trp Ser Thr 
    130                 135                 140                 


Val Gln Arg Ala Cys Gly Val Gln Val Ala Cys Gly Ala Ala Trp Thr 
145                 150                 155                 160 


Leu Ala Leu Leu Leu Thr Val Pro Ser Ala Ile Tyr Arg Arg Leu His 
                165                 170                 175     


Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val Asp Tyr Gly Gly 
            180                 185                 190         


Ser Ser Ser Thr Glu Asn Ala Val Thr Ala Ile Arg Phe Leu Phe Gly 
        195                 200                 205             


Phe Leu Gly Pro Leu Val Ala Val Ala Ser Cys His Ser Ala Leu Leu 
    210                 215                 220                 


Cys Trp Ala Ala Arg Arg Cys Arg Pro Leu Gly Thr Ala Ile Val Val 
225                 230                 235                 240 


Gly Phe Phe Val Cys Trp Ala Pro Tyr His Leu Leu Gly Leu Val Leu 
                245                 250                 255     


Thr Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg Ala 
            260                 265                 270         


Glu Pro Leu Ile Val Gly Leu Ala Leu Ala His Ser Cys Leu Asn Pro 
        275                 280                 285             


Met Leu Phe Leu Tyr Phe Gly Arg Ala Gln Leu Arg Arg Ser Leu Pro 
    290                 295                 300                 


Ala Ala Cys His Trp Ala Leu Arg Glu Ser Gln Gly Gln Asp Glu Ser 
305                 310                 315                 320 


Val Asp Ser Lys Lys Ser Thr Ser His Asp Leu Val Ser Glu Met Glu 
                325                 330                 335     


Val 
    






<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Ile Ala Arg Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg 
1               5                   10                  15      


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Arg Leu His Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val 
1               5                   10                  15      


Asp Tyr Gly Gly Ser Ser Ser Thr Glu Asn Ala Val Thr Ala Ile Arg 
            20                  25                  30          


<210>  26
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Thr Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg 
1               5                   10                  15      


Ala Glu 
        


















<210>  27
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg 
        35  





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