                         SEQUENCE LISTING

<110>  COMMISSARIAT A L'ENERGIE ATOMIQUE
       LE MAOULT, Jol        
       CAROSELLA, Edgardo Delfino 
       
 
<120>  MULTIMERIC POLYPEPTIDES OF HLA-G INCLUDING AT LEAST 
	TWO ALPHA3 DOMAINS AND PHARMACEUTICAL USES THEREOF

<130>  BLOcp263/407

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  92
<212>  PRT
<213>  human

<220>
<223>  HLA-G alpha3 peptide


<400>  1

Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu 
1               5                   10                  15      


Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile 
            20                  25                  30          


Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu 
        35                  40                  45              


Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala 
    50                  55                  60                  


Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln 
65                  70                  75                  80  


His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp 
                85                  90          


<210>  2
<211>  90
<212>  PRT
<213>  human

<220>
<223>  HLA-G alpha1 peptide


<400>  2

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala 
                85                  90  


<210>  3
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  alpha3-L1 peptide


<400>  3

Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ala Asp Pro 
1               5                   10                  15      


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
            20                  25                  30          


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
        35                  40                  45              


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
    50                  55                  60                  


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
65                  70                  75                  80  


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
                85                  90                  95      


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln 
            100                 105             


<210>  4
<211>  184
<212>  PRT
<213>  human

<220>
<223>  HLA-G alpha1-alpha3 peptide


<400>  4

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Asp Pro Pro Lys Thr His 
                85                  90                  95      


Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp 
            100                 105                 110         


Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp 
        115                 120                 125             


Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala 
    130                 135                 140                 


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
145                 150                 155                 160 


Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu 
                165                 170                 175     


Pro Leu Met Leu Arg Trp Lys Gln 
            180                 



<210>  5
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  alpha3-L2 peptide

<400>  5

Cys Ala Ser Asp Ser Asp Phe Arg Val Phe Gln Thr Asp Lys Glu Met 
1               5                   10                  15      


Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val 
            20                  25                  30          


Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        35                  40                  45              


Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
    50                  55                  60                  


Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
65                  70                  75                  80  


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                85                  90                  95      


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp 
            100                 105                 110         


Lys Gln 
        


<210>  6
<211>  338
<212>  PRT
<213>  human

<220>
<223>  HLA-G


<400>  6

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


