                         SEQUENCE LISTING

<110>  ID BIOMEDICAL CORPORATION OF QUEBEC
       GLAXOSMITHKLINE BIOLOGICALS, SA
       BLAIS, Normand
       RHEAULT, Patrick
       VAN-SCHERPENZEEL-THIM, Virginie
       VASSILEV, Ventzislav
 
<120>  VACCINE

<130>  VU63732_PCT

<150>  61/219,958
<151>  2009-06-24

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1697
<212>  DNA
<213>  respiratory syncytial virus

<400>  1
atggagttgc taatcctcaa agcaaatgca attaccacaa tcctcactgc agtcacattt       60

gttttgcttc tggtcaaaac atcactgaag aattttatca atcaacatgc agtgcagtag      120

caaaggctat cttagtgctc tgagaactgg ttggtatacc agtgttataa ctatagatta      180

agtaatatca aggaaaataa gtgtaatgga acagatgcta aggtaaaatt gataaacaag      240

aattagataa atataaaaat gctgtaacag aattgcagtt gctcatgcaa agcacccagc      300

aacaaacaat cgagccagaa gagaactacc aaggtttatg aattatacac tcaaaatgcc      360

aaaaaaacca atgtaacatt aagcaagaaa aggaaaagaa gatttcttgg tttttgttag      420

gtgttggatc tgcaatcgcc agtggcgttg ctgtatctaa ggtcctgcac ctgaagggga      480

agtgaacaag atcaaaagtg ctctactatc cacaaacaag gctgtagtca gttatcaaat      540

ggagttagtg tcttaaccag caaagtgtta gacctcaaaa actatataga aaacaattgt      600

tacctattgt gaacaagcaa agctgcagca tatcaaatat agcaactgta tagagttcca      660

acaaaagaac aacagactac tagagattac cagggaattt agtgttaagc aggtgtaact      720

acacctgtaa gcacttacat gttaactaat agtgaattat tgtcattatc aatgatatgc      780

ctataacaaa tgatcagaaa aagttaatgt ccaacaatgt tcaaatgtta gacagcaaag      840

ttactctatc atgtccataa taaaagagga agtcttagca tatgtgtaca attaccacta      900

tatggtgtta tagatacacc ctgttggaaa ctacacacat ccccctatgt acaaccaaca      960

caaaagaagg gtccaacatc tgtttaacaa gaactgacag aggtggtact gtgacaatgc     1020

aggatcagta tctttcttcc cacaagctga aacatgtaaa gtcaatcaaa tcgagtattt     1080

tgtgacacaa tgaacagttt aacattacca agtgaagtaa actctgcaat gttgacatat     1140

tcaaccccaa atatgattgt aaaattatga cttcaaaaac gatgtaagca gctccgttat     1200

cacatctcta ggagccattg tgtcatgcta tggcaaaaca aatgtacagc atccaataaa     1260

aatcgtggaa tcataaagac attttctaac gggtgcgata tgtatcaaat aaaggggtgg     1320

acactgtgtc tgtaggtaac acattatatt atgtaaaaag caagaaggta aaagtctcta     1380

tgtaaaaggt gaaccaataa taaatttcta tgacccttag tattcccctc tgatgaattt     1440

gatgcatcaa tatctcaagt caacgagaag attaacagag cctagcattt attcgtaaat     1500

ccgatgaatt attacataat gtaaatgctg gtaatccacc ataaatatca tgataactac     1560

tataattata gtgattatag taatattgtt atcttaattg ctgttggact gctcttatac     1620

tgtaaggcca gaagcacacc agtcacacta agaaagatca actgagtggt ataaataata     1680

ttgcatttag taactaa                                                    1697


<210>  2
<211>  574
<212>  PRT
<213>  respiratory syncytial virus

<400>  2

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Ala Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Ile Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  3
<211>  897
<212>  DNA
<213>  respiratory syncytial virus

<400>  3
atgtccaaaa acaaggacca acgcaccgct aagacactag aaaagacctg ggacactctc       60

aatcatttat tattcatatc atcgggctta tataagttaa atcttaaatc tatagcacaa      120

atcacattat ccattctggc aatgataatc tcaacttcac ttataattac agccatcata      180

ttcatagcct cggcaaacca caaagtcaca ctaacaactg caatcataca agatgcaaca      240

agccagatca agaacacaac cccaacatac ctcactcagg atcctcagct tggaatcagc      300

ttctccaatc tgtctgaaat tacatcacaa accaccacca tactagcttc aacaacacca      360

ggagtcaagt caaacctgca acccacaaca gtcaagacta aaaacacaac aacaacccaa      420

acacaaccca gcaagcccac tacaaaacaa cgccaaaaca aaccaccaaa caaacccaat      480

aatgattttc acttcgaagt gtttaacttt gtaccctgca gcatatgcag caacaatcca      540

acctgctggg ctatctgcaa aagaatacca aacaaaaaac caggaaagaa aaccaccacc      600

aagcctacaa aaaaaccaac cttcaagaca accaaaaaag atctcaaacc tcaaaccact      660

aaaccaaagg aagtacccac caccaagccc acagaagagc caaccatcaa caccaccaaa      720

acaaacatca caactacact gctcaccaac aacaccacag gaaatccaaa actcacaagt      780

caaatggaaa ccttccactc aacctcctcc gaaggcaatc taagcccttc tcaagtctcc      840

acaacatccg agcacccatc acaaccctca tctccaccca acacaacacg ccagtag         897


<210>  4
<211>  298
<212>  PRT
<213>  respiratory syncytial virus

<400>  4

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn His Leu Leu Phe Ile Ser Ser Gly Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Thr Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Lys Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Leu Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Thr Arg Gln 
    290                 295             


<210>  5
<211>  1620
<212>  DNA
<213>  human metapneumovirus

<400>  5
atgtcttgga aagtggtgat cattttttca ttgctaataa cacctcaaca cggtcttaaa       60

gagagctacc tagaagaatc atgtagcact ataactgagg gatatcttag tgttctgagg      120

acaggttggt ataccaacgt ttttacatta gaggtgggtg atgtagaaaa ccttacatgt      180

tctgatggac ctagcctaat aaaaacagaa ttagatctga ccaaaagtgc actaagagag      240

ctcaaaacag tctctgctga ccaattggca agagaggaac aaattgagaa tcccagacaa      300

tctaggtttg ttctaggagc aatagcactc ggtgttgcaa cagcagctgc agtcacagca      360

ggtgttgcaa ttgccaaaac catccggctt gagagtgaag tcacagcaat taagaatgcc      420

ctcaaaacga ccaatgaagc agtatctaca ttggggaatg gagttcgagt gttggcaact      480

gcagtgagag agctgaaaga ctttgtgagc aagaatttaa ctcgtgcaat caacaaaaac      540

aagtgcgaca ttgatgacct aaaaatggcc gttagcttca gtcaattcaa cagaaggttt      600

ctaaatgttg tgcggcaatt ttcagacaat gctggaataa caccagcaat atctttggac      660

ttaatgacag atgctgaact agccagggcc gtttctaaca tgccgacatc tgcaggacaa      720

ataaaattga tgttggagaa ccgtgcgatg gtgcgaagaa aggggttcgg aatcctgata      780

ggggtctacg ggagctccgt aatttacatg gtgcagctgc caatctttgg cgttatagac      840

acgccttgct ggatagtaaa agcagcccct tcttgttccg aaaaaaaggg aaactatgct      900

tgcctcttaa gagaagacca agggtggtat tgtcagaatg cagggtcaac tgtttactac      960

ccaaatgaga aagactgtga aacaagagga gaccatgtct tttgcgacac agcagcggga     1020

attaatgttg ctgagcaatc aaaggagtgc aacatcaaca tatccactac aaattaccca     1080

tgcaaagtca gcacaggaag acatcctatc agtatggttg cactgtctcc tcttggggct     1140

ctggttgctt gctacaaagg agtaagctgt tccattggca gcaacagagt agggatcatc     1200

aagcagctga acaagggttg ctcctatata accaaccaag atgcagacac agtgacaata     1260

gacaacactg tatatcagct aagcaaagtt gagggtgaac agcatgttat aaaaggcaga     1320

ccagtgtcaa gcagctttga tccaatcaag tttcctgaag atcaattcaa tgttgcactt     1380

gaccaagttt ttgagaacat tgaaaacagc caggccttgg tagatcaatc aaacagaatc     1440

ctaagcagtg cagagaaagg gaatactggc ttcatcattg taataattct aattgctgtc     1500

cttggctcta gcatgatcct agtgagcatc ttcattataa tcaagaaaac aaagaaacca     1560

acgggagcac ctccagagct gagtggtgtc acaaacaatg gcttcatacc acataattag     1620


<210>  6
<211>  539
<212>  PRT
<213>  human metapneumovirus

<400>  6

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Asn 
    530                 535                 


<210>  7
<211>  1620
<212>  DNA
<213>  parainfluenza virus 3

<400>  7
atgccaacct caatactgct aattattaca accatgatta tggcatcttt ctgccaaata       60

gatatcacaa aactacagca tgtaggtgta ttggttaaca gtcccaaagg gatgaagata      120

tcacaaaact ttgaaacaag atatctaatt ttgagcctca taccaaaaat agaagattct      180

aactcttgtg gtgaccaaca gatcaagcaa tacaagaggt tattggatag actgatcatt      240

cctttatatg atggattaag attacagaag gatgtgatag tgtccaatca agaatccaat      300

gaaaacactg accccagaac aaaacgattc tttggagggg taattggaac tattgctctg      360

ggagtggcaa cctcagcaca aattacagcg gcagttgctc tggttgaagc caagcaggca      420

agatcagaca ttgaaaaact caaggaagca atcagggaca caaacaaagc agtgcagtca      480

gtccagagct ccataggaaa tttgatagta gcaattaaat cggtccagga ttatgtcaac      540

aaagaaatcg tgccatcaat tgcgagatta ggttgtgaag cagcaggact tcagttagga      600

attgcattaa cacagcatta ctcagaatta acaaacatat tcggtgataa cataggatcg      660

ttacaagaaa aagggataaa attacaaggt atagcatcat tataccgcac aaatatcaca      720

gagatattca caacatcaac agttgataaa tatgatattt atgatctatt atttacagaa      780

tcaataaagg tgagagttat agatgttgac ttgaatgatt actcaatcac cctccaagtc      840

agactccctt tattaactag actgctgaac acccagattt acaaagtaga ttccatatca      900

tacaacatcc aaaacagaga atggtatatc cctcttccca gccacatcat gacaaaaggg      960

gcatttctag gtggagcaga tgtcaaagaa tgtatagaag cattcagcag ttatatatgc     1020

ccttctgatc caggatttgt actaaaccat gaaatggaga gctgtttatc aggaaacata     1080

tcccaatgtc caagaaccgt ggtcacatca gacattgttc caagatatgc atttgtcaat     1140

ggaggagtgg ttgcaaattg tataacaacc acatgtacat gcaacggtat cggcaataga     1200

atcaatcaac cacctgatca aggagtaaaa attataacac ataaagaatg taatacaata     1260

ggtatcaacg gaatgctgtt caatacaaat aaagaaggaa ctcttgcatt ttacacacca     1320

aatgatataa cattaaacaa ttctgttgca cttgatccaa ttgacatatc aatcgagctc     1380

aataaggcca aatcagatct agaagagtca aaagaatgga taagaaggtc aaatcaaaaa     1440

ctagattcca ttggaaattg gcatcaatct agcaccacaa tcataattgt tttgataatg     1500

ataattatat tgtttataat taatgtaacg ataattataa ttgcagttaa gtattacaga     1560

attcaaaaga gaaatcgagt ggatcaaaat gataaaccat atgtattaac aaacaaatga     1620


<210>  8
<211>  539
<212>  PRT
<213>  parainfluenza virus 3

<400>  8

Met Pro Thr Ser Ile Leu Leu Ile Ile Thr Thr Met Ile Met Ala Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln His Val Gly Val Leu Val 
            20                  25                  30          


Asn Ser Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asp Ser Asn Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Lys Gln Tyr Lys Arg Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Arg Leu Gln Lys Asp Val Ile Val Ser Asn 
                85                  90                  95      


Gln Glu Ser Asn Glu Asn Thr Asp Pro Arg Thr Lys Arg Phe Phe Gly 
            100                 105                 110         


Gly Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Lys Glu Ile Val Pro Ser Ile Ala Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Gln Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Ser Leu Gln Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr Arg Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Lys Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Val Arg Val Ile Asp Val Asp Leu Asn 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Arg Leu 
        275                 280                 285             


Leu Asn Thr Gln Ile Tyr Lys Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Asn Arg Glu Trp Tyr Ile Pro Leu Pro Ser His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Val Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Val Leu Asn His Glu Met 
            340                 345                 350         


Glu Ser Cys Leu Ser Gly Asn Ile Ser Gln Cys Pro Arg Thr Val Val 
        355                 360                 365             


Thr Ser Asp Ile Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Val Val 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Ile Gly Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Pro Pro Asp Gln Gly Val Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Asn Thr Ile Gly Ile Asn Gly Met Leu Phe Asn Thr Asn Lys Glu 
            420                 425                 430         


Gly Thr Leu Ala Phe Tyr Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Ile Gly Asn Trp His Gln Ser Ser Thr Thr Ile Ile Ile 
                485                 490                 495     


Val Leu Ile Met Ile Ile Ile Leu Phe Ile Ile Asn Val Thr Ile Ile 
            500                 505                 510         


Ile Ile Ala Val Lys Tyr Tyr Arg Ile Gln Lys Arg Asn Arg Val Asp 
        515                 520                 525             


Gln Asn Asp Lys Pro Tyr Val Leu Thr Asn Lys 
    530                 535                 


<210>  9
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide encoding RSV PreF analog

<400>  9
atggagctgc tgatcctgaa aaccaacgcc atcaccgcca tcctggccgc cgtgaccctg       60

tgcttcgcct cctcccagaa catcaccgag gagttctacc agtccacctg ctccgccgtg      120

tccaagggct acctgtccgc cctgcggacc ggctggtaca cctccgtgat caccatcgag      180

ctgtccaaca tcaaggaaaa caagtgcaac ggcaccgacg ccaaggtgaa gctgatcaag      240

caggagctgg acaagtacaa gagcgccgtg accgaactcc agctgctgat gcagtccacc      300

cctgccacca acaacaagtt tctgggcttc ctgctgggcg tgggctccgc catcgcctcc      360

ggcatcgccg tgagcaaggt gctgcacctg gagggcgagg tgaacaagat caagagcgcc      420

ctgctgtcca ccaacaaggc cgtggtgtcc ctgtccaacg gcgtgtccgt gctgacctcc      480

aaggtgctgg atctgaagaa ctacatcgac aagcagctgc tgcctatcgt gaacaagcag      540

tcctgctcca tctccaacat cgagaccgtg atcgagttcc agcagaagaa caaccggctg      600

ctggagatca cccgcgagtt ctccgtgaac gccggcgtga ccacccctgt gtccacctac      660

atgctgacca actccgagct gctgtccctg atcaacgaca tgcctatcac caacgaccag      720

aaaaaactga tgtccaacaa cgtgcagatc gtgcggcagc agtcctacag catcatgagc      780

atcatcaagg aagaggtgct ggcctacgtg gtgcagctgc ctctgtacgg cgtgatcgac      840

accccttgct ggaagctgca cacctccccc ctgtgcacca ccaacaccaa ggagggctcc      900

aacatctgcc tgacccggac cgaccggggc tggtactgcg acaacgccgg ctccgtgtcc      960

ttcttccctc tggccgagac ctgcaaggtg cagtccaacc gggtgttctg cgacaccatg     1020

aactccctga ccctgccttc cgaggtgaac ctgtgcaaca tcgacatctt caaccccaag     1080

tacgactgca agatcatgac cagcaagacc gacgtgtcct ccagcgtgat cacctccctg     1140

ggcgccatcg tgtcctgcta cggcaagacc aagtgcaccg cctccaacaa gaaccgggga     1200

atcatcaaga ccttctccaa cggctgcgac tacgtgtcca ataagggcgt ggacaccgtg     1260

tccgtgggca acacactgta ctacgtgaat aagcaggagg gcaagagcct gtacgtgaag     1320

ggcgagccta tcatcaactt ctacgaccct ctggtgttcc cttccgacga gttcgacgcc     1380

tccatcagcc aggtgaacga gaagatcaac cagtccctgg ccttcatccg gaagtccgac     1440

gagaagctgc ataacgtgga ggacaagatc gaggagatcc tgtccaaaat ctaccacatc     1500

gagaacgaga tcgcccggat caagaagctg atcggcgagg cctgataatc taga           1554


<210>  10
<211>  514
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic RSV PreF analog

<400>  10

Met Glu Leu Leu Ile Leu Lys Thr Asn Ala Ile Thr Ala Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Ser Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Lys Phe Leu Gly Phe Leu Leu 
            100                 105                 110         


Gly Val Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu 
        115                 120                 125             


His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr 
    130                 135                 140                 


Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser 
145                 150                 155                 160 


Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile 
                165                 170                 175     


Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu 
            180                 185                 190         


Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser 
        195                 200                 205             


Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn 
    210                 215                 220                 


Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln 
225                 230                 235                 240 


Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr 
                245                 250                 255     


Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln 
            260                 265                 270         


Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr 
        275                 280                 285             


Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu 
    290                 295                 300                 


Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser 
305                 310                 315                 320 


Phe Phe Pro Leu Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe 
                325                 330                 335     


Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys 
            340                 345                 350         


Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser 
        355                 360                 365             


Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val 
    370                 375                 380                 


Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly 
385                 390                 395                 400 


Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly 
                405                 410                 415     


Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln 
            420                 425                 430         


Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr 
        435                 440                 445             


Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln 
    450                 455                 460                 


Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp 
465                 470                 475                 480 


Glu Lys Leu His Asn Val Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys 
                485                 490                 495     


Ile Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly 
            500                 505                 510         


Glu Ala 
        


<210>  11
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide encoding hMPV PreF analog

<400>  11
atgagctgga aggtggtcat catcttctcc ctgctgatca ccccccagca cggcctgaaa       60

gagtcctacc tggaagagtc ctgctccacc atcaccgagg gctacctgtc cgtgctgcgg      120

accggctggt acaccaatgt gttcaccctg gaagtgggcg acgtggaaaa cctgacctgc      180

tccgacggcc ccagcctgat caagaccgag ctggacctga ccaagtccgc cctgcgcgag      240

ctgaaaaccg tgtccgccga ccagctggcc agagaggaac agatcgagaa ccccaagcag      300

tccaagttcg tgctgggcgc tatcgccctg ggcgtggcaa ccgctgctgc tgtgaccgct      360

ggcgtggcca ttgccaagac catccggctg gaatccgaag tgaccgccat caagaacgcc      420

ctgaaaacca ccaacgaggc cgtgtccacc ctgggcaatg gcgtgcgggt gctggctacc      480

gccgtgcggg aactgaagga cttcgtgtcc aagaacctga ccagggccat caacaagaac      540

aagtgcgaca tcgacgacct gaagatggcc gtcagcttca gccagttcaa ccggcggttc      600

ctgaacgtgg tccgacagtt ctccgacaac gccggcatca cccccgccat ctccctggac      660

ctgatgaccg atgccgagct ggccagggcc gtgtctaaca tgcccacctc tgccggccag      720

atcaagctga tgctggaaaa ccgggctatg gtccgacgga agggcttcgg catcctgatc      780

ggcgtgtacg gctcctccgt gatctacatg gtgcagctcc ccatcttcgg cgtgatcgac      840

accccctgct ggatcgtgaa ggccgctccc agctgctccg agaagaaggg caactacgcc      900

tgcctgctga gagaggacca gggctggtac tgccagaacg ccggctccac cgtgtactac      960

cccaacgaga aggactgcga gacacggggc gaccacgtgt tctgcgacac cgccgctggc     1020

atcaacgtgg ccgagcagtc caaagagtgc aacatcaaca tctccaccac caactacccc     1080

tgcaaggtgt ccaccggcag acaccccatc agcatggtgg ccctgagccc tctgggcgct     1140

ctggtggctt gctacaaggg cgtgtcctgc tctatcggct ccaacagagt gggcatcatc     1200

aagcagctga acaagggctg ctcctacatc accaaccagg acgccgacac cgtgaccatc     1260

gacaacaccg tgtaccagct gtccaaggtg gaaggcgagc agcacgtgat caagggcaga     1320

cccgtgtcct ccagcttcga ccccatcaag ttccccgagg accagttcaa tgtggccctg     1380

gaccaggtgt tcgagtccat cgagaactcc caggccctgg tggaccagtc caacagaatc     1440

ctgtcctctg ccgaggataa gatcgaggaa atcctgtcca aaatctacca catcgagaac     1500

gagatcgccc ggatcaagaa gctgatcggc gaggcc                               1536


<210>  12
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic hMPV PreF analog

<400>  12

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Lys Gln Ser Lys Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
                485                 490                 495     


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Ala 
            500                 505                 510         


<210>  13
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide encoding PIV-3 PreF analog

<400>  13
atgcccacct ccatcctgct gatcatcaca accatgatca tggccagctt ttgccagatc       60

gacatcacca agctccagca cgtgggcgtg ctggtcaact cccccaaggg catgaagatc      120

agccagaact tcgagacacg ctacctgatc ctgtccctga tccccaagat cgaggactcc      180

aactcctgcg gcgaccagca gatcaagcag tacaagcggc tgctggaccg gctgatcatc      240

cccctgtacg acggcctgcg gctccagaaa gacgtgatcg tgtccaacca ggaatccaac      300

gagaacaccg accccaagac caagaaattc ttcggcggcg tgatcggcac aatcgccctg      360

ggcgtggcca cctctgccca gatcaccgct gccgtggccc tggtggaagc caagcaggcc      420

agaagcgaca tcgagaagct gaaagaggcc atccgggaca ccaacaaggc cgtgcagagc      480

gtgcagtcct ccatcggcaa cctgatcgtg gccatcaagt ccgtgcagga ctacgtgaac      540

aaagaaatcg tgccctctat cgcccggctg ggctgtgaag ctgccggcct ccagctggga      600

atcgccctga cccagcacta ctccgagctg accaacatct tcggcgacaa catcggcagc      660

ctccaggaaa agggcatcaa gctccaggga atcgcctccc tgtaccggac caacatcacc      720

gagattttca ccacctccac cgtggataag tacgacatct acgacctgct gttcaccgag      780

tccatcaaag tgcgcgtgat cgacgtggac ctgaacgact acagcatcac cctccaggtc      840

cgactgcccc tgctgacccg gctgctgaac acccaaatct acaaggtgga ctccatctcc      900

tacaacatcc agaacagaga gtggtacatc cccctgccct cccacattat gaccaagggc      960

gccttcctgg gcggagccga cgtgaaagag tgcatcgagg ctttctccag ctacatctgc     1020

ccctccgacc ccggcttcgt gctgaaccac gagatggaat cctgcctgtc cggcaacatc     1080

tcccagtgcc cccggaccgt ggtcacatcc gacatcgtgc ccagatacgc cttcgtgaac     1140

ggcggcgtgg tggccaactg catcaccacc acctgtacct gcaacggcat cggcaacaga     1200

atcaaccagc cccccgacca gggcgtgaag attatcaccc acaaagagtg caacaccatc     1260

ggcatcaacg ggatgctgtt caacaccaac aaagagggca ccctggcctt ctacaccccc     1320

aacgacatca ccctgaacaa ctctgtggcc ctggacccca tcgacatctc catcgagctg     1380

aacaaggcca agtccgacct ggaagagtcc aaagagtgga tcagacggtc caaccagaag     1440

ctggacagca tcgaggacaa gatcgaagag atcctgtcca aaatctacca catcgagaac     1500

gagatcgccc ggatcaagaa gctgatcggc gaggcc                               1536


<210>  14
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic PIV-3 PreF analog

<400>  14

Met Pro Thr Ser Ile Leu Leu Ile Ile Thr Thr Met Ile Met Ala Ser 
1               5                   10                  15      


Phe Cys Gln Ile Asp Ile Thr Lys Leu Gln His Val Gly Val Leu Val 
            20                  25                  30          


Asn Ser Pro Lys Gly Met Lys Ile Ser Gln Asn Phe Glu Thr Arg Tyr 
        35                  40                  45              


Leu Ile Leu Ser Leu Ile Pro Lys Ile Glu Asp Ser Asn Ser Cys Gly 
    50                  55                  60                  


Asp Gln Gln Ile Lys Gln Tyr Lys Arg Leu Leu Asp Arg Leu Ile Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Gly Leu Arg Leu Gln Lys Asp Val Ile Val Ser Asn 
                85                  90                  95      


Gln Glu Ser Asn Glu Asn Thr Asp Pro Lys Thr Lys Lys Phe Phe Gly 
            100                 105                 110         


Gly Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile 
        115                 120                 125             


Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 
145                 150                 155                 160 


Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln 
                165                 170                 175     


Asp Tyr Val Asn Lys Glu Ile Val Pro Ser Ile Ala Arg Leu Gly Cys 
            180                 185                 190         


Glu Ala Ala Gly Leu Gln Leu Gly Ile Ala Leu Thr Gln His Tyr Ser 
        195                 200                 205             


Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Ser Leu Gln Glu Lys 
    210                 215                 220                 


Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr Arg Thr Asn Ile Thr 
225                 230                 235                 240 


Glu Ile Phe Thr Thr Ser Thr Val Asp Lys Tyr Asp Ile Tyr Asp Leu 
                245                 250                 255     


Leu Phe Thr Glu Ser Ile Lys Val Arg Val Ile Asp Val Asp Leu Asn 
            260                 265                 270         


Asp Tyr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Arg Leu 
        275                 280                 285             


Leu Asn Thr Gln Ile Tyr Lys Val Asp Ser Ile Ser Tyr Asn Ile Gln 
    290                 295                 300                 


Asn Arg Glu Trp Tyr Ile Pro Leu Pro Ser His Ile Met Thr Lys Gly 
305                 310                 315                 320 


Ala Phe Leu Gly Gly Ala Asp Val Lys Glu Cys Ile Glu Ala Phe Ser 
                325                 330                 335     


Ser Tyr Ile Cys Pro Ser Asp Pro Gly Phe Val Leu Asn His Glu Met 
            340                 345                 350         


Glu Ser Cys Leu Ser Gly Asn Ile Ser Gln Cys Pro Arg Thr Val Val 
        355                 360                 365             


Thr Ser Asp Ile Val Pro Arg Tyr Ala Phe Val Asn Gly Gly Val Val 
    370                 375                 380                 


Ala Asn Cys Ile Thr Thr Thr Cys Thr Cys Asn Gly Ile Gly Asn Arg 
385                 390                 395                 400 


Ile Asn Gln Pro Pro Asp Gln Gly Val Lys Ile Ile Thr His Lys Glu 
                405                 410                 415     


Cys Asn Thr Ile Gly Ile Asn Gly Met Leu Phe Asn Thr Asn Lys Glu 
            420                 425                 430         


Gly Thr Leu Ala Phe Tyr Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser 
        435                 440                 445             


Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys 
    450                 455                 460                 


Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys 
465                 470                 475                 480 


Leu Asp Ser Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
                485                 490                 495     


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Ala 
            500                 505                 510         


<210>  15
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic isoleucine zipper

<400>  15

Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn 
1               5                   10                  15      


Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Ala 
            20                  25              


