                         SEQUENCE LISTING

<110>  Dimarchi, et al.
 
<120>  GIP RECEPTOR-ACTIVE GLUCAGON COMPOUNDS

<130>  32993-212943

<160>  680   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is Arg, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at position 12 and 16

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (22)..(24)
<223>  Lactam ring between side chains at positions 22 and 24

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring formed between side chains at positions 24 and 28

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa is a variable amino acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, Ala, Gly, N-methyl Ser or Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids Exendin-4

<400>  26

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 8 
       amino acids of oxyntomodulin

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Arg Asn Arg 
1               


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exendin-4


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  C-terminal amidation

<400>  29

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly or an acidic amino acid

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cys

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cys

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  40

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Glu or Asp

<220>
<221>  MOS_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Glu or Thr

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  44

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Lys or Glu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Gln, Glu, Lys, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Glu or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Lys or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly or an acidic amino acid

<400>  45

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  50
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  50

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn, or Cit

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Glu, homoglutamic acid, or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly or an acidic amino acid

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  52

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or an acidic amino acid

<400>  53

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is Arg or Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Arg or Ala

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp or Glu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Ala

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Lys Xaa Phe Xaa Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His or alpha, alpha-dimethyl imidiazole acetic acid (DMIA), 
       N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, 
       aminoisobutyric acid (Aib) or N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Tyr or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Lys, Cit, Orn or Arg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is Arg, Gln, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Arg, Ala, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn or Cit

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Lys, Cys, Orn, homocystein or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Arg, Cit, Orn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl Phe

<400>  55

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or 
       N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn or Cit

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Cys, Orn, homocycstein or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln, Glu, Cys, Orn, homocycsteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl Phe

<400>  56

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl- His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, Aib or 
       N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side changes at position 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn or Cit

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Cys, Orn, homocycsteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl Phe

<400>  57

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or 
       N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl Phe

<400>  58

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB, or 
       N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at position 20 and 24

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl Phe

<400>  59

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or 
       N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln, Lys, Arg, Orn, or Cit

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at position 24 and 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is hr, Gly, Lys, Cys, Orn, homocysteine or acetyl Phe

<400>  60

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Glu Trp Leu Xaa Lys Xaa 
            20                  25                  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  Positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl, 
       Ala or D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is Cys-PEG or not present

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is Cys-PEG or is not present

<400>  61

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Xaa Ala Lys Asp Phe Val Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  Positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, 
       homo-His, DMIA, N-methyl His, alpha-methyl His, or imidazole 
       acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl 
       Ala, or D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is Cys-PEG or is not present

<400>  62

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Xaa Ala Lys Glu Phe Ile Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys or Asp

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exdendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Bound to PEG

<400>  65

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or Gly

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  87

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  89

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  90

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  91

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  92

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  93

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  94

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  95

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  96

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  97

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  98

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  99

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  100

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  101

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  102

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  103

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  109

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  110

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  112

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  113

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  114

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  115

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  116

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  119

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  120

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  129

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  134

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  135

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  137

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  138

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  139

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  140
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  140

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  141

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  142

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  143

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  146

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  147

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  148
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  149
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  149

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  152

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  153

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  154
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  154

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  155

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  156

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  157
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  157

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  158

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  159

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  160

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  161
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  161

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  162

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  163

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  164
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  164

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  165

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  166

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  167

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  168

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  169

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  170

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  171

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  172
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  172

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  173

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  174
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  174

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  175

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  177

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  181
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  184

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  185

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  186

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  187

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  188

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  189
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  190
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  191
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  192
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  193
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  195
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  196
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  197
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  198
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  199
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  202
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  202

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  203
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  204
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  204

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  206
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  206

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  207

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  208
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  208

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  209
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  209

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  210
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  210

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  211
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  211

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  212
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  212

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  213
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  213

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  214
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  214

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  215
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  215

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  216
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  216

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  217
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  217

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  218
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  218

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  219
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  219

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  220

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  221
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  221

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  222
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Bound to PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  222

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  223

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  224

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  225

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  226

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  227

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  228

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  229

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  230

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  231
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  231

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  232
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  232

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  233
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  233

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  234

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  235

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  236
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  236

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  237
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  237

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  238

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  239

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  240

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  241

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  242

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  243

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  244

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  245

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  246

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  247

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  248

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  249

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  250

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  251

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  252

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  253

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  254

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  255

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  256

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  257
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  257

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  258
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  258

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  259
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  259

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  260
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chrains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  260

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  261

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  262
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  263
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  264
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  265
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  267
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  268
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  269
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  270
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring betwee side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  271

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  272
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  274
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  274

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  275
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  275

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  276
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  276

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  277
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  277

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  278
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  278

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  279
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  279

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  280
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  280

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  281
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  281

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  282

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  283

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  284
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  284

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  285
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  285

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  286
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  286

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  287
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chain at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  287

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  288
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  288

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  289
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  289

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  290
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  290

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  291
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  291

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  292
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  292

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  293
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  293

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  294
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  294

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  295
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  295

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  296
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  296

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  297
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  297

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  298
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  298

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  299
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  299

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  300
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  300

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  301

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  302
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  302

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  303
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  303

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  304

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  305
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  305

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  306
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  306

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  307

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  308

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  309

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  310
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  310

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  311
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chain at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  311

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  312
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  312

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  313
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  313

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  314
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  314

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  315
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between seide chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  315

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  316
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  316

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  317
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 adn 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  317

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  318
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  318

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  319
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  319

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  320
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  320

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  321

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  322
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  322

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  323
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  323

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  324
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  324

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  325
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  325

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  326
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  326

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  327

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  328
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  328

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  329
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  329

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  330

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  331
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  331

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  332

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  333

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  334

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chainst at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  335

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  336
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  336

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  337
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  337

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  338
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam right between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  338

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  339
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  339

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  340
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  340

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  341
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  341

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  342
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  342

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  343
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  343

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  344
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  344

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  345
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  345

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  346
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  346

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  347
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  347

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  348
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  348

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  349
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  349

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  350
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  350

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  351
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  351

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  352
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  352

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  353
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  353

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  354
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  354

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  355
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  355

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  356
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  356

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  357
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  357

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  358
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  358

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  359

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  360
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  360

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  361
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  361

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  362
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  362

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  363

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  364
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  364

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  365

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  366
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  366

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  367

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  368
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  368

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  369
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  369

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  370
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  370

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  371
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  371

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  372
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  372

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  373
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  373

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  374
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  374

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  375
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  375

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  376
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  376

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  377
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  377

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  378

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  379
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  379

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  380
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  380

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  381
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  381

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  382
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  382

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  383
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  383

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  384
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  384

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  385

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  386
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  386

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  387
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  387

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  388
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  388

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  389
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  389

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  390
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  390

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  391
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  391

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  392
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  392

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  393
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  393

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  394
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  394

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  395
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  395

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  396
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  396

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  397
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  397

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  398
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  398

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  399
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  399

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  400
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  400

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  401
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  401

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  402
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  402

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  403

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  404
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  404

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  405
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  405

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  406
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  406

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  407
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  407

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  408
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  c-term amidation

<400>  408

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  409
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  409

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  410
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  410

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  411
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  411

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  412
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  412

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  413
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  413

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  414
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  414

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  415
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  415

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  416
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  416

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  417
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  417

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  418
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  418

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  419
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  419

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  420
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  420

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  421
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  421

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  422
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  422

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  423
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  423

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  424
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  424

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  425
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  425

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  426
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  426

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  427
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  427

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  428
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  428

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  429
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  429

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  430
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  430

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  431
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  431

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  432
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  432

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  433
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  433

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  434
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  434

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  435
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  435

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  436
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  436

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  437
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 16 and 20

<400>  437

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  438
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  438

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  439
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  439

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  440
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  440

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  441
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  441

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  442
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  442

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  443
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  443

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  444
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  444

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  445
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  445

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  446
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  446

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  447
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  447

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  448
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  448

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  449
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  449

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  450
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  450

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  451
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  451

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  452
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  C-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  452

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  453
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  453

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  454
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  454

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  455
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  455

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  456
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  456

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  457
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  457

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  458
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  458

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  459
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  459

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  460
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  460

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  461
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  461

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  462
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  462

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  463
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  463

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  464
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  464

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  465
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  465

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  466
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at postions 12 and 16

<400>  466

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  467
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  467

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  468
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  468

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  469
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  469

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  470
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  470

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  471
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  471

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  472
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  472

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  473
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  473

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  474
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  474

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  475
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  475

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  476
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  476

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  477
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  477

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  478
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  478

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  479
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  479

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  480
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  480

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  481
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  481

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  482
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  482

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  483
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  483

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  484
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  484

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  485
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  485

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  486
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  486

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  487
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  487

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  488
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  488

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  489
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  489

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  490
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  490

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  491
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  491

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  492
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  492

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  493
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  493

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  494
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  494

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  495
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  495

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  496
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  496

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  497
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  497

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  498
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  498

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr Ala 
            20                  25                  30  


<210>  499
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  499

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  500
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  500

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  501
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  501

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  502
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  502

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  503
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  503

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  504
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  504

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  505
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  505

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  506
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  506

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  507
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  507

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  508
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  508

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  509
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  509

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  510
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  510

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  511
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  511

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  512
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  512

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  513
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  513

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  514
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  514

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  515

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  516
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Cys-PEG

<400>  516

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10          


<210>  517
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  517

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  518
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  518

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  519
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  519

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  520
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  520

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  521
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  521

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  522
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  522

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  523
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  523

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  524
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  524

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  525
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  525

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  526
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  526

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  527
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  527

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  528
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  528

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  529
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  529

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  530
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  530

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  531
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  531

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  532
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Cys-PEG

<400>  532

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys Cys 
        35                  40      


<210>  533
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  c-term amidation

<400>  533

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  534
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C8 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C8 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  534

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  535
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C14 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  535

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  536
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C16 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  536

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  537
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  537

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  538
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  538

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  539
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  539

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<400>  540

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  541
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  541

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  542
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acid

<400>  542

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  543
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<400>  543

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  544
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<400>  544

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  545
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  545

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  546
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  546

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  547
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  547

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  548
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  548

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16 amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Glu residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  549

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  550
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by one amino acid

<400>  550

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn 
            20                  25              


<210>  551
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by two amino acids

<400>  551

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met 
            20                  25          


<210>  552
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-28, E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  552

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn 
            20                  25              


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-27 E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  553

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Lys Met 
            20                  25          


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Norleucine

<400>  554

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  555
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  mt-138

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridging side chains at positions 16 and 20

<400>  555

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  556
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 with AIB at 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  556

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  557
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  557

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  558
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  558

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  559
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutric Acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutric Acid

<400>  559

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  560
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  560

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  561
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<400>  561

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  562
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  562

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  563
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 50

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  563

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  564
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 82

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  564

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  565
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 83

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  565

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  566
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 84

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  566

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  567
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 85

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  567

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  568
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 86

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  568

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  569
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 87

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  569

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  570
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 77*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  570

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  571
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 78*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  571

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  572
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 78

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  572

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  573
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 81*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  573

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  574
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 81

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  574

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  575
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 79*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  575

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  576
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 80*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  576

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  577
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  gamma-Glu-gamma-Glu C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  577

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  578
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  gamma-Glu-gamma-Glu-C16 Glucagon Amide

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  578

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  579
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  AA-C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<400>  579

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  580
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2, AIB2, Lys10, Cys24-PEG

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  580

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  581
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  581

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  582
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  582

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  583
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  583

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  584
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  584

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  585
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K10-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  585

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  586
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K30-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<400>  586

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  587
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<400>  587

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  588
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  588

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  589
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<400>  589

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  590
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  590

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  591
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide J

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  591

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  592
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide K

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  592

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  593
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  593

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  594
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  594

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  595
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  595

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  596
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  596

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  597
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  597

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  598
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  598

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  599
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  599

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  600
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  600

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  601
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  601

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  602
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  602

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  603
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  603

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  604
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  604

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  605
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  605

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  606
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  606

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  607
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  607

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  608
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  608

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  609
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  609

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  610
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  610

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  611
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  611

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  612
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  612

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  613
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  613

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  614
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  614

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  615
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  615

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  616
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  616

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  617
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  617

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  618
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  618

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  619
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  619

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  620
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  620

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  621
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  621

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  622
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  622

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  623
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  beta-Ala-beta-Ala - C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<400>  623

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  624
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2C24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  624

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  625
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of the amino acids at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  625

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  626
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2E16K20lactamC24amideMal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  626

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  627

<400>  627
000

<210>  628
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  628

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  629
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<400>  629

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24thioether40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at position 16 and
       20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  630

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  631
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera2 Aib2E3C24-Thioether40K PEG(NOF)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  631

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  632
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  632

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  633
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  633

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  634
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C14)C24PEG40K TE amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  634

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  635
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  635

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  636
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  636

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  637
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  637

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  638
caaggtccag ggaggttgtg                                                   20


<210>  639
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  639
ccaaaggtaa gctgtccata agga                                              24


<210>  640
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  640
ctctcccaag agtcacatgt cc                                                22


<210>  641
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  641
caataactcg gtcccctaca ac                                                22


<210>  642
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  642

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  643
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  643

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  644
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  644

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  645
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  645

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  646
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  646

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  647
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  647

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  648
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  648

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  649
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  649

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  650
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  650

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  651
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  651

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  652
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  652

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  653
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  653

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  654
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  654

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  655
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  655

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  656
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  656

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  657
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-345

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  657

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  658
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-346

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  658

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  659
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-347

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  659

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  660
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-348

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  660

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  661
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-349

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  661

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  662
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-350

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  662

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  663
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-351

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  663

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  664
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-352

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  664

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  665

<400>  665
000

<210>  666
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-361

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  666

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  667
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-362

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  667

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  668
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-363

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  668

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  669
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-364

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  669

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  670
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  MT-261

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  670

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  671
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  mt-278

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  671

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  672
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  MT-297

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  672

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  673
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  MT-358

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  673

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  674
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  674

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  675
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (1)..(42)
<223>  Gastric inhibitory polypeptide

<400>  675

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  676
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  676

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  677
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  677

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  678

<400>  678
000

<210>  679
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-387

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Lys or Ile

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  679

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  680
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Lys or Ile

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  680

His Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


