                         SEQUENCE LISTING

<110>  The Translational Genomics Research Institute
       Schneider, Armin
       Spoelgen, Robert
       Huentelman, Matthew
 
<120>  IDENTIFICATION AND ASSESSMENT OF MEMORY MODULATING COMPOUNDS

<130>  TGEN-PCT

<150>  US 61/187,061
<151>  2009-06-16

<150>  EP10001268
<151>  2010-02-08

<160>  7    

<170>  PatentIn version 3.3

<210>  1
<211>  4160
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(3423)

<400>  1
ctggagccgc tgagcccccg ctgcggccgg gagctgcatg ggggagcgcc ggcagcgctt     60

gggaag atg ccc cgg ccg gag ctg ccc ctg ccg gag ggc tgg gag gag       108
       Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly Trp Glu Glu          
       1               5                   10                           

gcg cgc gac ttc gac ggc aag gtc tac tac ata gac cac acg aac cgc      156
Ala Arg Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His Thr Asn Arg         
15                  20                  25                  30          

acc acc agc tgg atc gac ccg cgg gac agg tac acc aaa ccg ctc acc      204
Thr Thr Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys Pro Leu Thr         
                35                  40                  45              

ttt gct gac tgc att agt gat gag ttg ccg cta gga tgg gaa gag gca      252
Phe Ala Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp Glu Glu Ala         
            50                  55                  60                  

tat gac cca cag gtt gga gat tac ttc ata gac cac aac acc aaa acc      300
Tyr Asp Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn Thr Lys Thr         
        65                  70                  75                      

act cag att gag gat cct cga gta caa tgg cgg cgg gag cag gaa cat      348
Thr Gln Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu Gln Glu His         
    80                  85                  90                          

atg ctg aag gat tac ctg gtg gtg gcc cag gag gct ctg agt gca caa      396
Met Leu Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu Ser Ala Gln         
95                  100                 105                 110         

aag gag atc tac cag gtg aag cag cag cgc ctg gag ctt gca cag cag      444
Lys Glu Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu Ala Gln Gln         
                115                 120                 125             

gag tac cag caa ctg cat gcc gtc tgg gag cat aag ctg ggc tcc cag      492
Glu Tyr Gln Gln Leu His Ala Val Trp Glu His Lys Leu Gly Ser Gln         
            130                 135                 140                 

gtc agc ttg gtc tct ggt tca tca tcc agc tcc aag tat gac cct gag      540
Val Ser Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr Asp Pro Glu         
        145                 150                 155                     

atc ctg aaa gct gaa att gcc act gca aaa tcc cgg gtc aac aag ctg      588
Ile Leu Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val Asn Lys Leu         
    160                 165                 170                         

aag aga gag atg gtt cac ctc cag cac gag ctg cag ttc aaa gag cgt      636
Lys Arg Glu Met Val His Leu Gln His Glu Leu Gln Phe Lys Glu Arg         
175                 180                 185                 190         

ggc ttt cag acc ctg aag aaa atc gat aag aaa atg tct gat gct cag      684
Gly Phe Gln Thr Leu Lys Lys Ile Asp Lys Lys Met Ser Asp Ala Gln         
                195                 200                 205             

ggc agc tac aaa ctg gat gaa gct cag gct gtc ttg aga gaa aca aaa      732
Gly Ser Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg Glu Thr Lys         
            210                 215                 220                 

gcc atc aaa aag gct att acc tgt ggg gaa aag gaa aag caa gat ctc      780
Ala Ile Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu         
        225                 230                 235                     

att aag agc ctt gcc atg ttg aag gac ggc ttc cgc act gac agg ggg      828
Ile Lys Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly         
    240                 245                 250                         

tct cac tca gac ctg tgg tcc agc agc agc tct ctg gag agt tcg agt      876
Ser His Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser         
255                 260                 265                 270         

ttc ccg cta ccg aaa cag tac ctg gat gtg agc tcc cag aca gac atc      924
Phe Pro Leu Pro Lys Gln Tyr Leu Asp Val Ser Ser Gln Thr Asp Ile         
                275                 280                 285             

tcg gga agc ttc ggc atc aac agc aac aat cag ttg gca gag aag gtc      972
Ser Gly Ser Phe Gly Ile Asn Ser Asn Asn Gln Leu Ala Glu Lys Val         
            290                 295                 300                 

aga ttg cgc ctt cga tat gaa gag gct aag aga agg atc gcc aac ctg     1020
Arg Leu Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu         
        305                 310                 315                     

aag atc cag ctg gcc aag ctt gac agt gag gcc tgg cct ggg gtg ctg     1068
Lys Ile Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu         
    320                 325                 330                         

gac tca gag agg gac cgg ctg atc ctt atc aac gag aag gag gag ctg     1116
Asp Ser Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu         
335                 340                 345                 350         

ctg aag gag atg cgc ttc atc agc ccc cgc aag tgg acc cag ggg gag     1164
Leu Lys Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu         
                355                 360                 365             

gtg gag cag ctg gag atg gcc cgg aag cgg ctg gaa aag gac ctg cag     1212
Val Glu Gln Leu Glu Met Ala Arg Lys Arg Leu Glu Lys Asp Leu Gln         
            370                 375                 380                 

gca gcc cgg gac acc cag agc aag gcg ctg acg gag agg tta aag tta     1260
Ala Ala Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu         
        385                 390                 395                     

aac agt aag agg aac cag ctt gtg aga gaa ctg gag gaa gcc acc cgg     1308
Asn Ser Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg         
    400                 405                 410                         

cag gtg gca act ctg cac tcc cag ctg aaa agt ctc tca agc agc atg     1356
Gln Val Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met         
415                 420                 425                 430         

cag tcc ctg tcc tca ggc agc agc ccc gga tcc ctc acg tcc agc cgg     1404
Gln Ser Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg         
                435                 440                 445             

ggc tcc ctg gtt gca tcc agc ctg gac tcc tcc act tca gcc agc ttc     1452
Gly Ser Leu Val Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe         
            450                 455                 460                 

act gac ctc tac tat gac ccc ttt gag cag ctg gac tca gag ctg cag     1500
Thr Asp Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Gln         
        465                 470                 475                     

agc aag gtg gag ttc ctg ctc ctg gag ggg gcc acc ggc ttc cgg ccc     1548
Ser Lys Val Glu Phe Leu Leu Leu Glu Gly Ala Thr Gly Phe Arg Pro         
    480                 485                 490                         

tca ggc tgc atc acc acc atc cac gag gat gag gtg gcc aag acc cag     1596
Ser Gly Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln         
495                 500                 505                 510         

aag gca gag gga ggt ggc cgc ctg cag gct ctg cgt tcc ctg tct ggc     1644
Lys Ala Glu Gly Gly Gly Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly         
                515                 520                 525             

acc cca aag tcc atg acc tcc cta tcc cca cgt tcc tct ctc tcc tcc     1692
Thr Pro Lys Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser         
            530                 535                 540                 

ccc tcc cca ccc tgt tcc cct ctc atg gct gac ccc ctc ctg gct ggt     1740
Pro Ser Pro Pro Cys Ser Pro Leu Met Ala Asp Pro Leu Leu Ala Gly         
        545                 550                 555                     

gat gcc ttc ctc aac tcc ttg gag ttt gaa gac ccg gag ctg agt gcc     1788
Asp Ala Phe Leu Asn Ser Leu Glu Phe Glu Asp Pro Glu Leu Ser Ala         
    560                 565                 570                         

act ctt tgt gaa ctg agc ctt ggt aac agc gcc cag gaa aga tac cgg     1836
Thr Leu Cys Glu Leu Ser Leu Gly Asn Ser Ala Gln Glu Arg Tyr Arg         
575                 580                 585                 590         

ctg gag gaa cca gga acg gag ggc aag cag ctg ggc caa gct gtg aat     1884
Leu Glu Glu Pro Gly Thr Glu Gly Lys Gln Leu Gly Gln Ala Val Asn         
                595                 600                 605             

acg gcc cag ggg tgt ggc ctg aaa gtg gcc tgt gtc tca gcc gcc gta     1932
Thr Ala Gln Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val         
            610                 615                 620                 

tcg gac gag tca gtg gct gga gac agt ggt gtg tac gag gct tcc gtg     1980
Ser Asp Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Val         
        625                 630                 635                     

cag aga ctg ggt gct tca gaa gct gct gca ttt gac agt gac gaa tcg     2028
Gln Arg Leu Gly Ala Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser         
    640                 645                 650                         

gaa gca gtg ggt gcg acc cga att cag att gcc ctg aag tat gat gag     2076
Glu Ala Val Gly Ala Thr Arg Ile Gln Ile Ala Leu Lys Tyr Asp Glu         
655                 660                 665                 670         

aag aat aag caa ttt gca ata tta atc atc cag ctg agt aac ctt tct     2124
Lys Asn Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu Ser Asn Leu Ser         
                675                 680                 685             

gct ctg ttg cag caa caa gac cag aaa gtg aat atc cgc gtg gct gtc     2172
Ala Leu Leu Gln Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Val         
            690                 695                 700                 

ctt cct tgc tct gaa agc aca acc tgc ctg ttc cgg acc cgg cct ctg     2220
Leu Pro Cys Ser Glu Ser Thr Thr Cys Leu Phe Arg Thr Arg Pro Leu         
        705                 710                 715                     

gac gcc tca gac act cta gtg ttc aat gag gtg ttc tgg gta tcc atg     2268
Asp Ala Ser Asp Thr Leu Val Phe Asn Glu Val Phe Trp Val Ser Met         
    720                 725                 730                         

tcc tat cca gcc ctt cac cag aag acc tta aga gtc gat gtc tgt acc     2316
Ser Tyr Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr         
735                 740                 745                 750         

acc gac agg agc cat ctg gaa gag tgc ctg gga ggc gcc cag atc agc     2364
Thr Asp Arg Ser His Leu Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser         
                755                 760                 765             

ctg gcg gag gtc tgc cgg tct ggg gag agg tcg act cgc tgg tac aac     2412
Leu Ala Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn         
            770                 775                 780                 

ctt ctc agc tac aaa tac ttg aag aaa cag agc agg gag ctc aag cca     2460
Leu Leu Ser Tyr Lys Tyr Leu Lys Lys Gln Ser Arg Glu Leu Lys Pro         
        785                 790                 795                     

gtg gga gtc atg gcc cct gcc tca ggg cct gcc agc acg gac gct gtg     2508
Val Gly Val Met Ala Pro Ala Ser Gly Pro Ala Ser Thr Asp Ala Val         
    800                 805                 810                         

tct gct ctg ttg gaa cag aca gca gtg gag ctg gag aag agg cag gag     2556
Ser Ala Leu Leu Glu Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu         
815                 820                 825                 830         

ggc agg agc agc aca cag aca ctg gaa gac agc tgg agg tat gag gag     2604
Gly Arg Ser Ser Thr Gln Thr Leu Glu Asp Ser Trp Arg Tyr Glu Glu         
                835                 840                 845             

acc agt gag aat gag gca gta gcc gag gaa gag gag gag gag gtg gag     2652
Thr Ser Glu Asn Glu Ala Val Ala Glu Glu Glu Glu Glu Glu Val Glu         
            850                 855                 860                 

gag gag gag gga gaa gag gat gtt ttc acc gag aaa gcc tca cct gat     2700
Glu Glu Glu Gly Glu Glu Asp Val Phe Thr Glu Lys Ala Ser Pro Asp         
        865                 870                 875                     

atg gat ggg tac cca gca tta aag gtg gac aaa gag acc aac acg gag     2748
Met Asp Gly Tyr Pro Ala Leu Lys Val Asp Lys Glu Thr Asn Thr Glu         
    880                 885                 890                         

acc ccg gcc cca tcc ccc aca gtg gtg cga cct aag gac cgg aga gtg     2796
Thr Pro Ala Pro Ser Pro Thr Val Val Arg Pro Lys Asp Arg Arg Val         
895                 900                 905                 910         

ggc acc ccg tcc cag ggg cca ttt ctt cga ggg agc acc atc atc cgc     2844
Gly Thr Pro Ser Gln Gly Pro Phe Leu Arg Gly Ser Thr Ile Ile Arg         
                915                 920                 925             

tct aag acc ttc tcc cca gga ccc cag agc cag tac gtg tgc cgg ctg     2892
Ser Lys Thr Phe Ser Pro Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu         
            930                 935                 940                 

aat cgg agt gat agt gac agc tcc act ctg tcc aaa aag cca cct ttt     2940
Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe         
        945                 950                 955                     

gtt cga aac tcc ctg gag cga cgc agc gtc cgg atg aag cgg ccg tcc     2988
Val Arg Asn Ser Leu Glu Arg Arg Ser Val Arg Met Lys Arg Pro Ser         
    960                 965                 970                         

cca ccc cca cag cct tcc tcg gtc aag tcg ctg cgc tcc gag cgt ctg     3036
Pro Pro Pro Gln Pro Ser Ser Val Lys Ser Leu Arg Ser Glu Arg Leu         
975                 980                 985                 990         

atc cgt acc tcg ctg gac ctg gag tta gac  ctg cag gcg aca aga  acc   3084
Ile Arg Thr Ser Leu Asp Leu Glu Leu Asp  Leu Gln Ala Thr Arg  Thr       
                995                 1000                 1005           

tgg cac agc caa  ttg acc cag gag atc  tcg gtg ctg aag gag  ctc      3129
Trp His Ser Gln  Leu Thr Gln Glu Ile  Ser Val Leu Lys Glu  Leu          
            1010                 1015                 1020              

aag gag cag ctg  gaa caa gcc aag agc  cac ggg gag aag gag  ctg      3174
Lys Glu Gln Leu  Glu Gln Ala Lys Ser  His Gly Glu Lys Glu  Leu          
            1025                 1030                 1035              

cca cag tgg ttg  cgt gag gac gag cgt  ttc cgc ctg ctg ctg  agg      3219
Pro Gln Trp Leu  Arg Glu Asp Glu Arg  Phe Arg Leu Leu Leu  Arg          
            1040                 1045                 1050              

atg ctg gag aag  cgg cag atg gac cga  gcg gag cac aag ggt  gag      3264
Met Leu Glu Lys  Arg Gln Met Asp Arg  Ala Glu His Lys Gly  Glu          
            1055                 1060                 1065              

ctt cag aca gac  aag atg atg agg gca  gct gcc aag gat gtg  cac      3309
Leu Gln Thr Asp  Lys Met Met Arg Ala  Ala Ala Lys Asp Val  His          
            1070                 1075                 1080              

agg ctc cga ggc  cag agc tgt aag gaa  ccc cca gaa gtt cag  tct      3354
Arg Leu Arg Gly  Gln Ser Cys Lys Glu  Pro Pro Glu Val Gln  Ser          
            1085                 1090                 1095              

ttc agg gag aag  atg gca ttt ttc acc  cgg cct cgg atg aat  atc      3399
Phe Arg Glu Lys  Met Ala Phe Phe Thr  Arg Pro Arg Met Asn  Ile          
            1100                 1105                 1110              

cca gct ctc tct  gca gat gac gtc taatcgccag aaaagtattt cctttgttcc   3453
Pro Ala Leu Ser  Ala Asp Asp Val                                        
            1115                                                        

actgaccagg ctgtgaacat tgactgtggc taaagttatt tatgtggtgt tatatgaagg   3513

tactgagtca caagtcctct agtgctcttg ttggtttgaa gatgaaccga ctttttagtt   3573

tgggtcctac tgttgttatt aaaaacagaa caaaaacaaa acacacacac acacaaaaac   3633

agaaacaaaa aaaaccagca ttaaaataat aagattgtat agtttgtata tttaggagtg   3693

tatttttggg aaagaaaatt taaatgaact aaagcagtat tgagttgctg ctcttcttaa   3753

aatcgtttag attttttttg gtttgtacag ctccaccttt tagaggtctt actgcaataa   3813

gaagtaatgc ctgggggacg gtaatcctaa taggacgtcc cgcacttgtc acagtacagc   3873

taatttttcc tagttaacat attttgtaca atattaaaaa aatgcacaga aaccattggg   3933

ggggattcag aggtgcatcc acggatcttc ttgagctgtg acgtgttttt atgtggctgc   3993

ccaacgtgga gcgggcagtg tgataggctg ggtgggctaa gcagcctagt ctatgtgggt   4053

gacaggccac gctggtctca gatgcccagt gaagccacta acatgagtga ggggagggct   4113

gtggggaact ccattcagtt ttatctccat caataaagtg gcctttc                 4160


<210>  2
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly Trp Glu Glu Ala Arg 
1               5                   10                  15      


Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His Thr Asn Arg Thr Thr 
            20                  25                  30          


Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys Pro Leu Thr Phe Ala 
        35                  40                  45              


Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp Glu Glu Ala Tyr Asp 
    50                  55                  60                  


Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Gln 
65                  70                  75                  80  


Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu Gln Glu His Met Leu 
                85                  90                  95      


Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu Ser Ala Gln Lys Glu 
            100                 105                 110         


Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu Ala Gln Gln Glu Tyr 
        115                 120                 125             


Gln Gln Leu His Ala Val Trp Glu His Lys Leu Gly Ser Gln Val Ser 
    130                 135                 140                 


Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr Asp Pro Glu Ile Leu 
145                 150                 155                 160 


Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val Asn Lys Leu Lys Arg 
                165                 170                 175     


Glu Met Val His Leu Gln His Glu Leu Gln Phe Lys Glu Arg Gly Phe 
            180                 185                 190         


Gln Thr Leu Lys Lys Ile Asp Lys Lys Met Ser Asp Ala Gln Gly Ser 
        195                 200                 205             


Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg Glu Thr Lys Ala Ile 
    210                 215                 220                 


Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu Ile Lys 
225                 230                 235                 240 


Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly Ser His 
                245                 250                 255     


Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser Phe Pro 
            260                 265                 270         


Leu Pro Lys Gln Tyr Leu Asp Val Ser Ser Gln Thr Asp Ile Ser Gly 
        275                 280                 285             


Ser Phe Gly Ile Asn Ser Asn Asn Gln Leu Ala Glu Lys Val Arg Leu 
    290                 295                 300                 


Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu Lys Ile 
305                 310                 315                 320 


Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu Asp Ser 
                325                 330                 335     


Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu Leu Lys 
            340                 345                 350         


Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu Val Glu 
        355                 360                 365             


Gln Leu Glu Met Ala Arg Lys Arg Leu Glu Lys Asp Leu Gln Ala Ala 
    370                 375                 380                 


Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu Asn Ser 
385                 390                 395                 400 


Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg Gln Val 
                405                 410                 415     


Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met Gln Ser 
            420                 425                 430         


Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg Gly Ser 
        435                 440                 445             


Leu Val Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe Thr Asp 
    450                 455                 460                 


Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Gln Ser Lys 
465                 470                 475                 480 


Val Glu Phe Leu Leu Leu Glu Gly Ala Thr Gly Phe Arg Pro Ser Gly 
                485                 490                 495     


Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln Lys Ala 
            500                 505                 510         


Glu Gly Gly Gly Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly Thr Pro 
        515                 520                 525             


Lys Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser Pro Ser 
    530                 535                 540                 


Pro Pro Cys Ser Pro Leu Met Ala Asp Pro Leu Leu Ala Gly Asp Ala 
545                 550                 555                 560 


Phe Leu Asn Ser Leu Glu Phe Glu Asp Pro Glu Leu Ser Ala Thr Leu 
                565                 570                 575     


Cys Glu Leu Ser Leu Gly Asn Ser Ala Gln Glu Arg Tyr Arg Leu Glu 
            580                 585                 590         


Glu Pro Gly Thr Glu Gly Lys Gln Leu Gly Gln Ala Val Asn Thr Ala 
        595                 600                 605             


Gln Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val Ser Asp 
    610                 615                 620                 


Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Val Gln Arg 
625                 630                 635                 640 


Leu Gly Ala Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser Glu Ala 
                645                 650                 655     


Val Gly Ala Thr Arg Ile Gln Ile Ala Leu Lys Tyr Asp Glu Lys Asn 
            660                 665                 670         


Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu Ser Asn Leu Ser Ala Leu 
        675                 680                 685             


Leu Gln Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Val Leu Pro 
    690                 695                 700                 


Cys Ser Glu Ser Thr Thr Cys Leu Phe Arg Thr Arg Pro Leu Asp Ala 
705                 710                 715                 720 


Ser Asp Thr Leu Val Phe Asn Glu Val Phe Trp Val Ser Met Ser Tyr 
                725                 730                 735     


Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr Thr Asp 
            740                 745                 750         


Arg Ser His Leu Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser Leu Ala 
        755                 760                 765             


Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn Leu Leu 
    770                 775                 780                 


Ser Tyr Lys Tyr Leu Lys Lys Gln Ser Arg Glu Leu Lys Pro Val Gly 
785                 790                 795                 800 


Val Met Ala Pro Ala Ser Gly Pro Ala Ser Thr Asp Ala Val Ser Ala 
                805                 810                 815     


Leu Leu Glu Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu Gly Arg 
            820                 825                 830         


Ser Ser Thr Gln Thr Leu Glu Asp Ser Trp Arg Tyr Glu Glu Thr Ser 
        835                 840                 845             


Glu Asn Glu Ala Val Ala Glu Glu Glu Glu Glu Glu Val Glu Glu Glu 
    850                 855                 860                 


Glu Gly Glu Glu Asp Val Phe Thr Glu Lys Ala Ser Pro Asp Met Asp 
865                 870                 875                 880 


Gly Tyr Pro Ala Leu Lys Val Asp Lys Glu Thr Asn Thr Glu Thr Pro 
                885                 890                 895     


Ala Pro Ser Pro Thr Val Val Arg Pro Lys Asp Arg Arg Val Gly Thr 
            900                 905                 910         


Pro Ser Gln Gly Pro Phe Leu Arg Gly Ser Thr Ile Ile Arg Ser Lys 
        915                 920                 925             


Thr Phe Ser Pro Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu Asn Arg 
    930                 935                 940                 


Ser Asp Ser Asp Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe Val Arg 
945                 950                 955                 960 


Asn Ser Leu Glu Arg Arg Ser Val Arg Met Lys Arg Pro Ser Pro Pro 
                965                 970                 975     


Pro Gln Pro Ser Ser Val Lys Ser Leu Arg Ser Glu Arg Leu Ile Arg 
            980                 985                 990         


Thr Ser Leu Asp Leu Glu Leu Asp  Leu Gln Ala Thr Arg  Thr Trp His 
        995                 1000                 1005             


Ser Gln  Leu Thr Gln Glu Ile  Ser Val Leu Lys Glu  Leu Lys Glu 
    1010                 1015                 1020             


Gln Leu  Glu Gln Ala Lys Ser  His Gly Glu Lys Glu  Leu Pro Gln 
    1025                 1030                 1035             


Trp Leu  Arg Glu Asp Glu Arg  Phe Arg Leu Leu Leu  Arg Met Leu 
    1040                 1045                 1050             


Glu Lys  Arg Gln Met Asp Arg  Ala Glu His Lys Gly  Glu Leu Gln 
    1055                 1060                 1065             


Thr Asp  Lys Met Met Arg Ala  Ala Ala Lys Asp Val  His Arg Leu 
    1070                 1075                 1080             


Arg Gly  Gln Ser Cys Lys Glu  Pro Pro Glu Val Gln  Ser Phe Arg 
    1085                 1090                 1095             


Glu Lys  Met Ala Phe Phe Thr  Arg Pro Arg Met Asn  Ile Pro Ala 
    1100                 1105                 1110             


Leu Ser  Ala Asp Asp Val 
    1115                  


<210>  3
<211>  4467
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (379)..(3690)

<400>  3
cgcgcggcgg ggctccggca gaggctgcgg gcggcggcgg cggcggcggc ggcgtggagc     60

gcagcgcgca gcggcagggg caggcaggcg gcggctcggg ccgctctcct ggctggctgg    120

ccgcggactc gggccggctg ggcgccgcgg cgggcgcaca tggcagcgtg agaggcgggc    180

ggcgtggggc tggggccgca gggccgcatg gacagaggcg ccaccccggc cggcccccgt    240

tagggccccc gatccgtggg cgccactccc cgatcatgct gcctcggcgg ccgcctggac    300

ccaaagcggc cagcccgagc cgctgagccc cgtggcggct gcgagctgca tgggggagcg    360

cgggccaggc tcgggaag atg ccc cgg ccg gag ttg ccc ctg ccg gag ggc      411
                    Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly         
                    1               5                   10              

tgg gag gag gcg cgc gac ttc gac ggc aag gtc tac tac ata gat cac      459
Trp Glu Glu Ala Arg Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His         
            15                  20                  25                  

agg aac cgc acc acc agc tgg atc gac ccg cgg gac agg tac acc aaa      507
Arg Asn Arg Thr Thr Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys         
        30                  35                  40                      

cca ctc acc ttc gct gac tgc atc agt gat gag tta ccg ctg gga tgg      555
Pro Leu Thr Phe Ala Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp         
    45                  50                  55                          

gaa gaa gca tac gac cca cag gtc gga gat tac ttc ata gac cac aat      603
Glu Glu Ala Tyr Asp Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn         
60                  65                  70                  75          

acc aaa acc act cag atc gag gat cca agg gtg caa tgg cgg cgg gaa      651
Thr Lys Thr Thr Gln Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu         
                80                  85                  90              

cag gag cac atg ctg aag gat tac ctg gtg gtg gct cag gaa gct ctg      699
Gln Glu His Met Leu Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu         
            95                  100                 105                 

agt gca caa aag gag atc tac cag gtg aag cag cag cgc ctg gag ctg      747
Ser Ala Gln Lys Glu Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu         
        110                 115                 120                     

gca cag cag gag tat cag cag ttg cat gcc gtc tgg gag cat aag ctg      795
Ala Gln Gln Glu Tyr Gln Gln Leu His Ala Val Trp Glu His Lys Leu         
    125                 130                 135                         

ggc tcc cag gtt agc ttg gtc tct gga tcc tcg tcc agc tcc aag tat      843
Gly Ser Gln Val Ser Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr         
140                 145                 150                 155         

gac ccc gag atc ctg aaa gct gaa att gcc act gca aag tcc cgg gtc      891
Asp Pro Glu Ile Leu Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val         
                160                 165                 170             

aac aag ctg aag aga gag atg gtt cac cta cag cat gag ctg cag ttc      939
Asn Lys Leu Lys Arg Glu Met Val His Leu Gln His Glu Leu Gln Phe         
            175                 180                 185                 

aag gag cgt ggc ttt cag acg ctg aag aaa att gat gag aga atg tca      987
Lys Glu Arg Gly Phe Gln Thr Leu Lys Lys Ile Asp Glu Arg Met Ser         
        190                 195                 200                     

gac gca cag ggt ggc tac aaa ctg gat gag gcc cag gct gtg ctg agg     1035
Asp Ala Gln Gly Gly Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg         
    205                 210                 215                         

gaa acc aaa gcc atc aag aaa gcc atc acc tgc gga gaa aag gag aaa     1083
Glu Thr Lys Ala Ile Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys         
220                 225                 230                 235         

caa gac ctc att aag agt ctc gcc atg ctg aag gat ggc ttc cgg aca     1131
Gln Asp Leu Ile Lys Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr         
                240                 245                 250             

gac aga ggg tca cac tcc gac cta tgg tcc agc agc agc tct ctg gag     1179
Asp Arg Gly Ser His Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu         
            255                 260                 265                 

agt tca agc ttc ccg atg cca aag cag ttc ctg gac gtg agc tcg cag     1227
Ser Ser Ser Phe Pro Met Pro Lys Gln Phe Leu Asp Val Ser Ser Gln         
        270                 275                 280                     

aca gac atc tct ggg agt ttc agc acc agc agc aac aat cag ttg gcc     1275
Thr Asp Ile Ser Gly Ser Phe Ser Thr Ser Ser Asn Asn Gln Leu Ala         
    285                 290                 295                         

gag aag gtc aga ttg cgc ctt cgg tat gaa gag gcg aag aga agg atc     1323
Glu Lys Val Arg Leu Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile         
300                 305                 310                 315         

gcc aac ctc aag atc cag ctg gcc aaa ctt gac agt gag gcc tgg cct     1371
Ala Asn Leu Lys Ile Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro         
                320                 325                 330             

ggg gtg cta gac tca gag agg gac cga ctg atc ctc atc aat gag aag     1419
Gly Val Leu Asp Ser Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys         
            335                 340                 345                 

gag gaa ctt ctg aag gaa atg cgc ttc atc agc ccc cgg aaa tgg acc     1467
Glu Glu Leu Leu Lys Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr         
        350                 355                 360                     

cag gga gag gtg gag caa ctg gag atg gcc cgg agg cga ctt gag aag     1515
Gln Gly Glu Val Glu Gln Leu Glu Met Ala Arg Arg Arg Leu Glu Lys         
    365                 370                 375                         

gac tta cag gca gcc cgg gac acc cag agc aag gcg ctg act gag agg     1563
Asp Leu Gln Ala Ala Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg         
380                 385                 390                 395         

ctg aag tta aat agc aag agg aac cag ctg gtg cga gaa ctg gag gaa     1611
Leu Lys Leu Asn Ser Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu         
                400                 405                 410             

gcc act cgg cag gtg gct acc ctg cac tcc cag ttg aaa agc ctc tca     1659
Ala Thr Arg Gln Val Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser         
            415                 420                 425                 

agc agc atg cag tcc ctg tct tca ggc agt agc cct ggg tca ctc acc     1707
Ser Ser Met Gln Ser Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr         
        430                 435                 440                     

tcc agc cgg ggc tcc ctg gcc gcc tct agc ctg gac tcc tcc acc tca     1755
Ser Ser Arg Gly Ser Leu Ala Ala Ser Ser Leu Asp Ser Ser Thr Ser         
    445                 450                 455                         

gcc agc ttc act gac ctc tat tat gac ccg ttc gag cag ttg gac tcg     1803
Ala Ser Phe Thr Asp Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser         
460                 465                 470                 475         

gag ctc cag agc aag gtg gag ctg ctg ttc ctg gag ggt gcc acg ggc     1851
Glu Leu Gln Ser Lys Val Glu Leu Leu Phe Leu Glu Gly Ala Thr Gly         
                480                 485                 490             

ttc cgg ccc tca ggc tgc atc acc acc atc cac gag gat gag gtg gcc     1899
Phe Arg Pro Ser Gly Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala         
            495                 500                 505                 

aag acc cag aag gca gag gga ggc agc cgc ctg cag gcc ctg cgc tcc     1947
Lys Thr Gln Lys Ala Glu Gly Gly Ser Arg Leu Gln Ala Leu Arg Ser         
        510                 515                 520                     

cta tct ggc act cca agg tcc atg acc tcc ctg tct cca cgc tca tct     1995
Leu Ser Gly Thr Pro Arg Ser Met Thr Ser Leu Ser Pro Arg Ser Ser         
    525                 530                 535                         

ctc tcc tcc cca tcc cct ccc tgt tcc cct ctc atc act gat ccc ctc     2043
Leu Ser Ser Pro Ser Pro Pro Cys Ser Pro Leu Ile Thr Asp Pro Leu         
540                 545                 550                 555         

ctg act gga gat gcc ttc ctg gcc ccg ctg gag ttt gaa gac aca gag     2091
Leu Thr Gly Asp Ala Phe Leu Ala Pro Leu Glu Phe Glu Asp Thr Glu         
                560                 565                 570             

ctg agt acc act ctc tgt gag ctg aac ctc ggc ggt agc ggc acc cag     2139
Leu Ser Thr Thr Leu Cys Glu Leu Asn Leu Gly Gly Ser Gly Thr Gln         
            575                 580                 585                 

gaa aga tac cgg ctg gag gaa cca gga cct gag ggc aag cca ctg ggc     2187
Glu Arg Tyr Arg Leu Glu Glu Pro Gly Pro Glu Gly Lys Pro Leu Gly         
        590                 595                 600                     

caa gct gca agt gtg gcc cca gga tgt ggc ctc aaa gta gcc tgt gtg     2235
Gln Ala Ala Ser Val Ala Pro Gly Cys Gly Leu Lys Val Ala Cys Val         
    605                 610                 615                         

tcc gct gca gtg tcc gac gag tca gta gcc ggg gac agt ggc gtg tat     2283
Ser Ala Ala Val Ser Asp Glu Ser Val Ala Gly Asp Ser Gly Val Tyr         
620                 625                 630                 635         

gag gct tca gca cag aga cca ggt act tct gaa gct gcc gca ttc gac     2331
Glu Ala Ser Ala Gln Arg Pro Gly Thr Ser Glu Ala Ala Ala Phe Asp         
                640                 645                 650             

agt gat gaa tcg gaa gct gtg ggt gcc act cgg gtt cag att gcc ctg     2379
Ser Asp Glu Ser Glu Ala Val Gly Ala Thr Arg Val Gln Ile Ala Leu         
            655                 660                 665                 

aaa tat gat gag aag aat aag caa ttt gca ata tta atc att cag ctg     2427
Lys Tyr Asp Glu Lys Asn Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu         
        670                 675                 680                     

agt cac ctc tct gct ctg tca cta caa caa gac cag aaa gtg aac atc     2475
Ser His Leu Ser Ala Leu Ser Leu Gln Gln Asp Gln Lys Val Asn Ile         
    685                 690                 695                         

cgt gta gcc atc ctg cct tgc tct gaa agc agc acc tgc ttg ttc aga     2523
Arg Val Ala Ile Leu Pro Cys Ser Glu Ser Ser Thr Cys Leu Phe Arg         
700                 705                 710                 715         

acc cgg cct ctg gac tcg gca aat acc ctc gtg ttc aat gag gca ttc     2571
Thr Arg Pro Leu Asp Ser Ala Asn Thr Leu Val Phe Asn Glu Ala Phe         
                720                 725                 730             

tgg gtg tcc atc tcc tac cca gcc ctt cac caa aag acc tta cga gtc     2619
Trp Val Ser Ile Ser Tyr Pro Ala Leu His Gln Lys Thr Leu Arg Val         
            735                 740                 745                 

gat gtc tgc acc act gac agg agc cat aca gag gag tgt ctg gga ggt     2667
Asp Val Cys Thr Thr Asp Arg Ser His Thr Glu Glu Cys Leu Gly Gly         
        750                 755                 760                     

gcc cag atc agc ctg gcc gag gtc tgc cgg tct ggg gag agg tca acg     2715
Ala Gln Ile Ser Leu Ala Glu Val Cys Arg Ser Gly Glu Arg Ser Thr         
    765                 770                 775                         

cgc tgg tac aat ctc ctg agc tac aaa tac ttg aag aag cag tgc agg     2763
Arg Trp Tyr Asn Leu Leu Ser Tyr Lys Tyr Leu Lys Lys Gln Cys Arg         
780                 785                 790                 795         

gag ccc cag cca aca gaa gct cca ggg cca gac cat gtg gac gct gtg     2811
Glu Pro Gln Pro Thr Glu Ala Pro Gly Pro Asp His Val Asp Ala Val         
                800                 805                 810             

tct gcc ttg cta gaa cag aca gcc gtg gag cta gag aag agg cag gag     2859
Ser Ala Leu Leu Glu Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu         
            815                 820                 825                 

gga aga agc agc tcc cag acg ctg gag ggc agc tgg acg tac gag gaa     2907
Gly Arg Ser Ser Ser Gln Thr Leu Glu Gly Ser Trp Thr Tyr Glu Glu         
        830                 835                 840                     

gag gcc agc gag aat gag gca gtc gct gag gag gaa gag gag gga gag     2955
Glu Ala Ser Glu Asn Glu Ala Val Ala Glu Glu Glu Glu Glu Gly Glu         
    845                 850                 855                         

gaa gat gtc ttc act gaa aag gtc tct ccc gag gca gag gag tgc cca     3003
Glu Asp Val Phe Thr Glu Lys Val Ser Pro Glu Ala Glu Glu Cys Pro         
860                 865                 870                 875         

gca tta aag gtg gac aga gag acc aat act gac agc gtg gcc cca tcc     3051
Ala Leu Lys Val Asp Arg Glu Thr Asn Thr Asp Ser Val Ala Pro Ser         
                880                 885                 890             

ccc aca gtg gtg cgc cct aag gac cgg agg gtg ggt gcc ccg tcg aca     3099
Pro Thr Val Val Arg Pro Lys Asp Arg Arg Val Gly Ala Pro Ser Thr         
            895                 900                 905                 

ggg cca ttt ctt cga ggg aat acc atc atc cgc tcc aag acc ttc tcg     3147
Gly Pro Phe Leu Arg Gly Asn Thr Ile Ile Arg Ser Lys Thr Phe Ser         
        910                 915                 920                     

cct gga ccc cag agc cag tat gtg tgt cgg cta aac cgc agt gac agt     3195
Pro Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu Asn Arg Ser Asp Ser         
    925                 930                 935                         

gat agt tct acg ctg tcc aag aag cca cct ttt gtg cga aac tcc ctg     3243
Asp Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe Val Arg Asn Ser Leu         
940                 945                 950                 955         

gag cgg cgc agc gtc agg atg aag cgg cct tcc tcc gtc aag tcc ctg     3291
Glu Arg Arg Ser Val Arg Met Lys Arg Pro Ser Ser Val Lys Ser Leu         
                960                 965                 970             

cgc aca gag cgt ctg atc cgc acc tcg ctg gac cta gaa ctc gac ctg     3339
Arg Thr Glu Arg Leu Ile Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu         
            975                 980                 985                 

cag gcc acg agg acc tgg cac agc cag ctg act cag gag  atc tca gtg    3387
Gln Ala Thr Arg Thr Trp His Ser Gln Leu Thr Gln Glu  Ile Ser Val        
        990                 995                 1000                    

ctg aag  gag ctg aag gag cat  ttg gag caa gcc aag  aac cac ggg      3432
Leu Lys  Glu Leu Lys Glu His  Leu Glu Gln Ala Lys  Asn His Gly          
    1005                 1010                 1015                      

gag aag  gag ctg cca cag tgg  ctg cgt gaa gac gag  cgc ttc cgc      3477
Glu Lys  Glu Leu Pro Gln Trp  Leu Arg Glu Asp Glu  Arg Phe Arg          
    1020                 1025                 1030                      

ttg cta  ctg agg atg ctg gag  aag aag gtg gat cgt  ggg gag cac      3522
Leu Leu  Leu Arg Met Leu Glu  Lys Lys Val Asp Arg  Gly Glu His          
    1035                 1040                 1045                      

aag agt  gag ttg caa gcc gac  aag atg atg aga gct  gct gcc aag      3567
Lys Ser  Glu Leu Gln Ala Asp  Lys Met Met Arg Ala  Ala Ala Lys          
    1050                 1055                 1060                      

gat gtg  cac agg ctt cga ggc  cag agc tgt aag gag  ccc cca gaa      3612
Asp Val  His Arg Leu Arg Gly  Gln Ser Cys Lys Glu  Pro Pro Glu          
    1065                 1070                 1075                      

gtg cag  tct ttc agg gag aaa  atg gca ttt ttc acc  cgg cct cgg      3657
Val Gln  Ser Phe Arg Glu Lys  Met Ala Phe Phe Thr  Arg Pro Arg          
    1080                 1085                 1090                      

atg aac  atc cca gct ctc tct  gca gat gac gtc taaccaccag            3700
Met Asn  Ile Pro Ala Leu Ser  Ala Asp Asp Val                           
    1095                 1100                                           

aaaagtattt cctttgtctc gtgcgcgcgc gtgcagacca agctgtgaag gctgactgtg   3760

actaatgtta tttatgaggc attatatgaa ggtactgagt cacaagtccc cgagcgctct   3820

tgttggtttg aagacagatt ttttttttaa atttcaggtt ttcttgttat tatttaaaaa   3880

aaaaaatgac aaagcaacca taacaacaaa aacaaaaacc aaacaaacaa aaaaaccagc   3940

attaaaatga caagattgta tagtttgtat atttaggaat gtatttttgg gaaagaattt   4000

aaatgaacta aagcagcatt aagtggctgc tagtcttaaa actgtctaga gttttctttt   4060

tgtacagcaa caactttcag aggtttccct gcaataataa aaaaaaaaaa agttgtattt   4120

gaggggcgac aatcctcaaa ggaggtcccg cgggtggcac agcacagcta gcctgccctg   4180

gttaacgtta ttttgtacaa taatacaaag acaaggatgt acagtaatcg tgggggaatt   4240

cgaagactgt ccgcggatct ttgtgagctg tgatgtgtct ttcatgtggc cacgtgaccg   4300

tgaccggaag caggtagcct ggagctggct gaaccgcccg gactggtgac aggccacgcc   4360

caggccacgc ccatctcaga tgcccagtga cgcagctgtg ggagtgaggg gagggctgcg   4420

gagaaccgca tttggatcta tctctaacaa taaagtggcc ttttaag                 4467


<210>  4
<211>  1104
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly Trp Glu Glu Ala Arg 
1               5                   10                  15      


Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His Arg Asn Arg Thr Thr 
            20                  25                  30          


Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys Pro Leu Thr Phe Ala 
        35                  40                  45              


Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp Glu Glu Ala Tyr Asp 
    50                  55                  60                  


Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Gln 
65                  70                  75                  80  


Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu Gln Glu His Met Leu 
                85                  90                  95      


Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu Ser Ala Gln Lys Glu 
            100                 105                 110         


Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu Ala Gln Gln Glu Tyr 
        115                 120                 125             


Gln Gln Leu His Ala Val Trp Glu His Lys Leu Gly Ser Gln Val Ser 
    130                 135                 140                 


Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr Asp Pro Glu Ile Leu 
145                 150                 155                 160 


Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val Asn Lys Leu Lys Arg 
                165                 170                 175     


Glu Met Val His Leu Gln His Glu Leu Gln Phe Lys Glu Arg Gly Phe 
            180                 185                 190         


Gln Thr Leu Lys Lys Ile Asp Glu Arg Met Ser Asp Ala Gln Gly Gly 
        195                 200                 205             


Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg Glu Thr Lys Ala Ile 
    210                 215                 220                 


Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu Ile Lys 
225                 230                 235                 240 


Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly Ser His 
                245                 250                 255     


Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser Phe Pro 
            260                 265                 270         


Met Pro Lys Gln Phe Leu Asp Val Ser Ser Gln Thr Asp Ile Ser Gly 
        275                 280                 285             


Ser Phe Ser Thr Ser Ser Asn Asn Gln Leu Ala Glu Lys Val Arg Leu 
    290                 295                 300                 


Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu Lys Ile 
305                 310                 315                 320 


Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu Asp Ser 
                325                 330                 335     


Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu Leu Lys 
            340                 345                 350         


Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu Val Glu 
        355                 360                 365             


Gln Leu Glu Met Ala Arg Arg Arg Leu Glu Lys Asp Leu Gln Ala Ala 
    370                 375                 380                 


Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu Asn Ser 
385                 390                 395                 400 


Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg Gln Val 
                405                 410                 415     


Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met Gln Ser 
            420                 425                 430         


Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg Gly Ser 
        435                 440                 445             


Leu Ala Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe Thr Asp 
    450                 455                 460                 


Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Gln Ser Lys 
465                 470                 475                 480 


Val Glu Leu Leu Phe Leu Glu Gly Ala Thr Gly Phe Arg Pro Ser Gly 
                485                 490                 495     


Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln Lys Ala 
            500                 505                 510         


Glu Gly Gly Ser Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly Thr Pro 
        515                 520                 525             


Arg Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser Pro Ser 
    530                 535                 540                 


Pro Pro Cys Ser Pro Leu Ile Thr Asp Pro Leu Leu Thr Gly Asp Ala 
545                 550                 555                 560 


Phe Leu Ala Pro Leu Glu Phe Glu Asp Thr Glu Leu Ser Thr Thr Leu 
                565                 570                 575     


Cys Glu Leu Asn Leu Gly Gly Ser Gly Thr Gln Glu Arg Tyr Arg Leu 
            580                 585                 590         


Glu Glu Pro Gly Pro Glu Gly Lys Pro Leu Gly Gln Ala Ala Ser Val 
        595                 600                 605             


Ala Pro Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val Ser 
    610                 615                 620                 


Asp Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Ala Gln 
625                 630                 635                 640 


Arg Pro Gly Thr Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser Glu 
                645                 650                 655     


Ala Val Gly Ala Thr Arg Val Gln Ile Ala Leu Lys Tyr Asp Glu Lys 
            660                 665                 670         


Asn Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu Ser His Leu Ser Ala 
        675                 680                 685             


Leu Ser Leu Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Ile Leu 
    690                 695                 700                 


Pro Cys Ser Glu Ser Ser Thr Cys Leu Phe Arg Thr Arg Pro Leu Asp 
705                 710                 715                 720 


Ser Ala Asn Thr Leu Val Phe Asn Glu Ala Phe Trp Val Ser Ile Ser 
                725                 730                 735     


Tyr Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr Thr 
            740                 745                 750         


Asp Arg Ser His Thr Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser Leu 
        755                 760                 765             


Ala Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn Leu 
    770                 775                 780                 


Leu Ser Tyr Lys Tyr Leu Lys Lys Gln Cys Arg Glu Pro Gln Pro Thr 
785                 790                 795                 800 


Glu Ala Pro Gly Pro Asp His Val Asp Ala Val Ser Ala Leu Leu Glu 
                805                 810                 815     


Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu Gly Arg Ser Ser Ser 
            820                 825                 830         


Gln Thr Leu Glu Gly Ser Trp Thr Tyr Glu Glu Glu Ala Ser Glu Asn 
        835                 840                 845             


Glu Ala Val Ala Glu Glu Glu Glu Glu Gly Glu Glu Asp Val Phe Thr 
    850                 855                 860                 


Glu Lys Val Ser Pro Glu Ala Glu Glu Cys Pro Ala Leu Lys Val Asp 
865                 870                 875                 880 


Arg Glu Thr Asn Thr Asp Ser Val Ala Pro Ser Pro Thr Val Val Arg 
                885                 890                 895     


Pro Lys Asp Arg Arg Val Gly Ala Pro Ser Thr Gly Pro Phe Leu Arg 
            900                 905                 910         


Gly Asn Thr Ile Ile Arg Ser Lys Thr Phe Ser Pro Gly Pro Gln Ser 
        915                 920                 925             


Gln Tyr Val Cys Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu 
    930                 935                 940                 


Ser Lys Lys Pro Pro Phe Val Arg Asn Ser Leu Glu Arg Arg Ser Val 
945                 950                 955                 960 


Arg Met Lys Arg Pro Ser Ser Val Lys Ser Leu Arg Thr Glu Arg Leu 
                965                 970                 975     


Ile Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu Gln Ala Thr Arg Thr 
            980                 985                 990         


Trp His Ser Gln Leu Thr Gln Glu  Ile Ser Val Leu Lys  Glu Leu Lys 
        995                 1000                 1005             


Glu His  Leu Glu Gln Ala Lys  Asn His Gly Glu Lys  Glu Leu Pro 
    1010                 1015                 1020             


Gln Trp  Leu Arg Glu Asp Glu  Arg Phe Arg Leu Leu  Leu Arg Met 
    1025                 1030                 1035             


Leu Glu  Lys Lys Val Asp Arg  Gly Glu His Lys Ser  Glu Leu Gln 
    1040                 1045                 1050             


Ala Asp  Lys Met Met Arg Ala  Ala Ala Lys Asp Val  His Arg Leu 
    1055                 1060                 1065             


Arg Gly  Gln Ser Cys Lys Glu  Pro Pro Glu Val Gln  Ser Phe Arg 
    1070                 1075                 1080             


Glu Lys  Met Ala Phe Phe Thr  Arg Pro Arg Met Asn  Ile Pro Ala 
    1085                 1090                 1095             


Leu Ser  Ala Asp Asp Val 
    1100                  


<210>  5
<211>  4181
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (93)..(3416)

<400>  5
gcggccgcct ggacccaaag cggccggcct gagccgctga gccccgtggc ggccgcgagc     60

tgcatggggg agcgcgggcc aggctcggga ag atg ccc cgg ccg gag ttg ccc      113
                                    Met Pro Arg Pro Glu Leu Pro         
                                    1               5                   

ctg ccg gag ggc tgg gag gag gcg cgc gac ttc gac ggc aag gtc tac      161
Leu Pro Glu Gly Trp Glu Glu Ala Arg Asp Phe Asp Gly Lys Val Tyr         
        10                  15                  20                      

tac ata gat cac agg aac cgc acc acc agc tgg atc gac ccg cgg gac      209
Tyr Ile Asp His Arg Asn Arg Thr Thr Ser Trp Ile Asp Pro Arg Asp         
    25                  30                  35                          

agg tac acc aaa cca ctc acc ttt gct gac tgc att agc gac gag ttg      257
Arg Tyr Thr Lys Pro Leu Thr Phe Ala Asp Cys Ile Ser Asp Glu Leu         
40                  45                  50                  55          

ccg ctg gga tgg gaa gaa gcg tat gat cca cag gtt gga gat tac ttc      305
Pro Leu Gly Trp Glu Glu Ala Tyr Asp Pro Gln Val Gly Asp Tyr Phe         
                60                  65                  70              

ata gac cac aat acc aaa acc act cag atc gag gat ccg agg gtg caa      353
Ile Asp His Asn Thr Lys Thr Thr Gln Ile Glu Asp Pro Arg Val Gln         
            75                  80                  85                  

tgg cgg cgg gaa caa gag cac atg ctg aag gat tac ctg gtg gtg gcc      401
Trp Arg Arg Glu Gln Glu His Met Leu Lys Asp Tyr Leu Val Val Ala         
        90                  95                  100                     

cag gag gct ctg agt gca caa aag gag atc tac cag gtg aag cag cag      449
Gln Glu Ala Leu Ser Ala Gln Lys Glu Ile Tyr Gln Val Lys Gln Gln         
    105                 110                 115                         

cgc ctg gag ctg gca cag cag gag tat cag cag ttg cat gcc gtc tgg      497
Arg Leu Glu Leu Ala Gln Gln Glu Tyr Gln Gln Leu His Ala Val Trp         
120                 125                 130                 135         

gag cat aag ctg ggc tcc cag gtt agc ttg gtc tcg gga tcc tcc tcc      545
Glu His Lys Leu Gly Ser Gln Val Ser Leu Val Ser Gly Ser Ser Ser         
                140                 145                 150             

agc tca aag tat gac cct gag atc ctg aaa gct gaa att gcc acc gca      593
Ser Ser Lys Tyr Asp Pro Glu Ile Leu Lys Ala Glu Ile Ala Thr Ala         
            155                 160                 165                 

aag tcc cgg gtg aac aaa ctg aag aga gag atg gtc cac cta cag cac      641
Lys Ser Arg Val Asn Lys Leu Lys Arg Glu Met Val His Leu Gln His         
        170                 175                 180                     

gag cta cag ttc aag gag cgt ggc ttt cag acc ctg aag aaa att gat      689
Glu Leu Gln Phe Lys Glu Arg Gly Phe Gln Thr Leu Lys Lys Ile Asp         
    185                 190                 195                         

gag agg atg tcc gat gct cag ggt ggc tac aaa ctg gac gaa gcc cag      737
Glu Arg Met Ser Asp Ala Gln Gly Gly Tyr Lys Leu Asp Glu Ala Gln         
200                 205                 210                 215         

gct gtg ctg agg gaa acc aaa gcc atc aag aaa gcc atc acc tgc gga      785
Ala Val Leu Arg Glu Thr Lys Ala Ile Lys Lys Ala Ile Thr Cys Gly         
                220                 225                 230             

gaa aag gag aaa caa gac ctg atc aag agt ctc gcc atg ctg aag gac      833
Glu Lys Glu Lys Gln Asp Leu Ile Lys Ser Leu Ala Met Leu Lys Asp         
            235                 240                 245                 

ggc ttc cgg acg gac aga ggg tcg cac tcc gac ctg tgg tcc agc agc      881
Gly Phe Arg Thr Asp Arg Gly Ser His Ser Asp Leu Trp Ser Ser Ser         
        250                 255                 260                     

agc tct ctg gag agt tcg agc ttc cca gtg cca aag cag ttc ctg gat      929
Ser Ser Leu Glu Ser Ser Ser Phe Pro Val Pro Lys Gln Phe Leu Asp         
    265                 270                 275                         

gtg agc tcg cag aca gac atc tct ggg agt ttc agc acc agc agc agc      977
Val Ser Ser Gln Thr Asp Ile Ser Gly Ser Phe Ser Thr Ser Ser Ser         
280                 285                 290                 295         

aac cag ttg gcc gag aag gtc cga ttg cgc ctt cgg tat gaa gag gca     1025
Asn Gln Leu Ala Glu Lys Val Arg Leu Arg Leu Arg Tyr Glu Glu Ala         
                300                 305                 310             

aag aga agg atc gcc aac ctc aag atc cag ctg gcc aaa ctt gac agt     1073
Lys Arg Arg Ile Ala Asn Leu Lys Ile Gln Leu Ala Lys Leu Asp Ser         
            315                 320                 325                 

gag gcc tgg cct gga gtg cta gac tca gag agg gac cga ctg atc ctc     1121
Glu Ala Trp Pro Gly Val Leu Asp Ser Glu Arg Asp Arg Leu Ile Leu         
        330                 335                 340                     

atc aat gag aag gag gag ctt ctg aag gag atg cgc ttc atc agc ccc     1169
Ile Asn Glu Lys Glu Glu Leu Leu Lys Glu Met Arg Phe Ile Ser Pro         
    345                 350                 355                         

cgg aaa tgg acg cag ggt gaa gtg gag cag cta gag atg gcc cgg agg     1217
Arg Lys Trp Thr Gln Gly Glu Val Glu Gln Leu Glu Met Ala Arg Arg         
360                 365                 370                 375         

aga ctg gag aag gac ttg cag gca gcc cgg gac acc cag agc aag gcg     1265
Arg Leu Glu Lys Asp Leu Gln Ala Ala Arg Asp Thr Gln Ser Lys Ala         
                380                 385                 390             

ctg act gag agg ttg aag tta aac agc aag agg aac cag ctg gtg cga     1313
Leu Thr Glu Arg Leu Lys Leu Asn Ser Lys Arg Asn Gln Leu Val Arg         
            395                 400                 405                 

gaa ctg gag gaa gcc acg cgg cag gtg gcc gcc ctg cac tct cag ttg     1361
Glu Leu Glu Glu Ala Thr Arg Gln Val Ala Ala Leu His Ser Gln Leu         
        410                 415                 420                     

aaa agc ctc tcc agc agt atg caa tca ctg tct tca ggc agt agc cct     1409
Lys Ser Leu Ser Ser Ser Met Gln Ser Leu Ser Ser Gly Ser Ser Pro         
    425                 430                 435                         

ggg tca ctt acg tcc agc cgg ggc tcc ctg gct gcc tct agc ctg gac     1457
Gly Ser Leu Thr Ser Ser Arg Gly Ser Leu Ala Ala Ser Ser Leu Asp         
440                 445                 450                 455         

tcc tcc acc tca gcc agc ttc act gac ctc tat tac gac ccg ttc gag     1505
Ser Ser Thr Ser Ala Ser Phe Thr Asp Leu Tyr Tyr Asp Pro Phe Glu         
                460                 465                 470             

cag ctg gac tca gag ctc ccg agc aaa gta gaa ctg ctg ttc ctg gag     1553
Gln Leu Asp Ser Glu Leu Pro Ser Lys Val Glu Leu Leu Phe Leu Glu         
            475                 480                 485                 

ggt gcc aca ggc ttc cgg ccc tca ggc tgc atc acc acc atc cac gag     1601
Gly Ala Thr Gly Phe Arg Pro Ser Gly Cys Ile Thr Thr Ile His Glu         
        490                 495                 500                     

gat gag gtg gcc aag act cag aag gca gag gga ggc agc cgc ctg cag     1649
Asp Glu Val Ala Lys Thr Gln Lys Ala Glu Gly Gly Ser Arg Leu Gln         
    505                 510                 515                         

gcc ctg cgc tcc cta tcc ggc act cca aga tcc atg acc tcc ctg tct     1697
Ala Leu Arg Ser Leu Ser Gly Thr Pro Arg Ser Met Thr Ser Leu Ser         
520                 525                 530                 535         

cca cgc tca tct ctc tcc tcc ccg tcc cct ccc tgt tcc cct ctc atc     1745
Pro Arg Ser Ser Leu Ser Ser Pro Ser Pro Pro Cys Ser Pro Leu Ile         
                540                 545                 550             

gct gac ccc ctc ctg gct gga gat gcc ttt ctg acc cct ctg gag ttt     1793
Ala Asp Pro Leu Leu Ala Gly Asp Ala Phe Leu Thr Pro Leu Glu Phe         
            555                 560                 565                 

gaa gac aca gag ctg agc ccc act ctt tgt gag ctg agc ctc ggc acc     1841
Glu Asp Thr Glu Leu Ser Pro Thr Leu Cys Glu Leu Ser Leu Gly Thr         
        570                 575                 580                     

gat ggc gcc cgg gaa aga ttc cgg ctg gag gaa cca gga ccc gag ggc     1889
Asp Gly Ala Arg Glu Arg Phe Arg Leu Glu Glu Pro Gly Pro Glu Gly         
    585                 590                 595                         

aaa cca ctg ggc cag gct gca agt gtg gcc cca ggg tgt ggc ctc aaa     1937
Lys Pro Leu Gly Gln Ala Ala Ser Val Ala Pro Gly Cys Gly Leu Lys         
600                 605                 610                 615         

gtg gcc tgt gtg tcc gct gca gtg tct gat gag tca gtg gcc ggg gac     1985
Val Ala Cys Val Ser Ala Ala Val Ser Asp Glu Ser Val Ala Gly Asp         
                620                 625                 630             

agc ggc gtg tat gag gct tcc atg cag aga cta ggt act tct gag gct     2033
Ser Gly Val Tyr Glu Ala Ser Met Gln Arg Leu Gly Thr Ser Glu Ala         
            635                 640                 645                 

gct gca ttc gac agc gac gag tcg gaa gct gtg ggt gtc act cag gtt     2081
Ala Ala Phe Asp Ser Asp Glu Ser Glu Ala Val Gly Val Thr Gln Val         
        650                 655                 660                     

cag att gcc ctg aaa tat gat gag aag agt aag cag ttt gca ata tta     2129
Gln Ile Ala Leu Lys Tyr Asp Glu Lys Ser Lys Gln Phe Ala Ile Leu         
    665                 670                 675                         

gtc atc cag ctg agt aac ctc tct gcc ctg tta cta cag caa gat cag     2177
Val Ile Gln Leu Ser Asn Leu Ser Ala Leu Leu Leu Gln Gln Asp Gln         
680                 685                 690                 695         

aaa gtg aac atc cgt gta gcc atc ttg cct tgc tct gaa agc agc acc     2225
Lys Val Asn Ile Arg Val Ala Ile Leu Pro Cys Ser Glu Ser Ser Thr         
                700                 705                 710             

tgc ttg ttc aga acc cgg cct ctg gac tct gca gat agc ctt gtg ttc     2273
Cys Leu Phe Arg Thr Arg Pro Leu Asp Ser Ala Asp Ser Leu Val Phe         
            715                 720                 725                 

aat gag gca ttc tgg gtg tcc atg tcc tac cca gcc ctt cac cag aag     2321
Asn Glu Ala Phe Trp Val Ser Met Ser Tyr Pro Ala Leu His Gln Lys         
        730                 735                 740                     

acc tta cga gtt gat gtc tgc acc act gac agg agc cat aca gag gag     2369
Thr Leu Arg Val Asp Val Cys Thr Thr Asp Arg Ser His Thr Glu Glu         
    745                 750                 755                         

tgc ctg gga ggt gcc cag atc agc ctg gct gag gtc tgc cgg tcc ggg     2417
Cys Leu Gly Gly Ala Gln Ile Ser Leu Ala Glu Val Cys Arg Ser Gly         
760                 765                 770                 775         

gag agg tca acc cgc tgg tac aac ctt ctg agc tac aaa tac ttg aag     2465
Glu Arg Ser Thr Arg Trp Tyr Asn Leu Leu Ser Tyr Lys Tyr Leu Lys         
                780                 785                 790             

aaa cag ggc agg gag ccc cag cca gca gaa gct cca ggg ccc gac cat     2513
Lys Gln Gly Arg Glu Pro Gln Pro Ala Glu Ala Pro Gly Pro Asp His         
            795                 800                 805                 

gtg gat gcc gtg tct gcc ttg cta gaa cag aca gct gtg gaa cta gag     2561
Val Asp Ala Val Ser Ala Leu Leu Glu Gln Thr Ala Val Glu Leu Glu         
        810                 815                 820                     

aag agg cag gag ggg aga agc agc tcc cag aca ctg gag ggc agc tgg     2609
Lys Arg Gln Glu Gly Arg Ser Ser Ser Gln Thr Leu Glu Gly Ser Trp         
    825                 830                 835                         

acg tac gag gaa gag gcc agc gag aat gag gca gta gct gag gag gaa     2657
Thr Tyr Glu Glu Glu Ala Ser Glu Asn Glu Ala Val Ala Glu Glu Glu         
840                 845                 850                 855         

gag aga gag gaa gag gag gga gag gaa gat gtc ttc gct gaa aag gtc     2705
Glu Arg Glu Glu Glu Glu Gly Glu Glu Asp Val Phe Ala Glu Lys Val         
                860                 865                 870             

tcc ccg gag gca gag gag tgc cca gca tta aag gtg gac aga gag acc     2753
Ser Pro Glu Ala Glu Glu Cys Pro Ala Leu Lys Val Asp Arg Glu Thr         
            875                 880                 885                 

aat act gac agc gtg acc cca tcc ccc aca gtg gtg cgc ccc aaa gac     2801
Asn Thr Asp Ser Val Thr Pro Ser Pro Thr Val Val Arg Pro Lys Asp         
        890                 895                 900                     

cgg cgg gtg ggt gcc ccc tcg cca ggg cca ttt ctt cga ggg aat acc     2849
Arg Arg Val Gly Ala Pro Ser Pro Gly Pro Phe Leu Arg Gly Asn Thr         
    905                 910                 915                         

atc atc cgc tcc aag acc ttc tcg cct gga ccc cag agc cag tat gtg     2897
Ile Ile Arg Ser Lys Thr Phe Ser Pro Gly Pro Gln Ser Gln Tyr Val         
920                 925                 930                 935         

tgt cgg ctg aat cga agc gac agc gac agc tcc acg ctg tcc aag aag     2945
Cys Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ser Lys Lys         
                940                 945                 950             

cca ccc ttt gtt cga aac tcc ctg gag cgg cgc agc gtc agg atg aag     2993
Pro Pro Phe Val Arg Asn Ser Leu Glu Arg Arg Ser Val Arg Met Lys         
            955                 960                 965                 

cgg cct tcg tcc gtc aag tcg ctg cgc aca gag cgc ctg atc cgc acc     3041
Arg Pro Ser Ser Val Lys Ser Leu Arg Thr Glu Arg Leu Ile Arg Thr         
        970                 975                 980                     

tcg ctg gac cta gaa cta gac ctg cag gcc acg agg acc tgg cac agc     3089
Ser Leu Asp Leu Glu Leu Asp Leu Gln Ala Thr Arg Thr Trp His Ser         
    985                 990                 995                         

cag  ctg act cag gag atc  tca gtg ctg aag gaa  ctg aag gag cat      3134
Gln  Leu Thr Gln Glu Ile  Ser Val Leu Lys Glu  Leu Lys Glu His          
1000                 1005                 1010                          

ttg  gag caa gcc aag aac  cac ggg gag aag gag  ctg cca caa tgg      3179
Leu  Glu Gln Ala Lys Asn  His Gly Glu Lys Glu  Leu Pro Gln Trp          
1015                 1020                 1025                          

ctg  cgt gaa gat gag cgc  ttc cgc ctc cta ctg  agg atg ctg gag      3224
Leu  Arg Glu Asp Glu Arg  Phe Arg Leu Leu Leu  Arg Met Leu Glu          
1030                 1035                 1040                          

aag  agg gtg gat cgc ggg  gag cac aag agc gag  ttg cag gcc gac      3269
Lys  Arg Val Asp Arg Gly  Glu His Lys Ser Glu  Leu Gln Ala Asp          
1045                 1050                 1055                          

aag  atg atg agg gca gct  gcc aag gac gtg cac  agg ctc cga ggc      3314
Lys  Met Met Arg Ala Ala  Ala Lys Asp Val His  Arg Leu Arg Gly          
1060                 1065                 1070                          

cag  agc tgt aag gag ccc  ccg gaa gtg cag tct  ttc agg gag aaa      3359
Gln  Ser Cys Lys Glu Pro  Pro Glu Val Gln Ser  Phe Arg Glu Lys          
1075                 1080                 1085                          

atg  gca ttt ttc acc cgg  cct cgg atg aac atc  cca gct ctc tct      3404
Met  Ala Phe Phe Thr Arg  Pro Arg Met Asn Ile  Pro Ala Leu Ser          
1090                 1095                 1100                          

gcc  gat gac gtc taaccaccag aaaagtattt cctttcttgc acggaccatg        3456
Ala  Asp Asp Val                                                        
1105                                                                    

ctgtgacggc tgactgtgac taaagttatt tatgaggcat tatgtgaagg taccgagtca   3516

caggtccccg agcgctctcg ttggtttgaa gacaaacaga tttttttttt tagttcaggt   3576

tttcttgata ttatttaaaa aaaaaatgac aaagcaacca taacaacaac aacaaaaaca   3636

aacaaacaaa caaacaaaaa aaccagcatt aaaatgacaa gattgtatag tttgtatatt   3696

taggaatgta tttttgggaa agaatttaaa tgaactaaag cagcgttaag cggctgctag   3756

tcttaaaatt gtctagagtt ttctttttgt acagcaacaa cttttagagg tttccctgca   3816

ataaaaaaaa aaaaaagaag tcgcatttga agggcgataa tcctccgagg aggtcccgca   3876

ggtggcacgg cacagctaac ctgtcctagt taacattatt ttgtacaata atacaaagag   3936

gaggatgtac agaaatcgtg gggttgtcgc agactgtcct cggatctttg tgagcttcga   3996

tgtgtcttcg tgtggccacc tgacctgaag caggcagcgt gaagctggct gggcaaggcc   4056

agcccagaca ggcggcaggc cacgcccatc tcagataccc agtgacactg ctgcgggagt   4116

gaggggaggg ccgcagagaa ctgcatttgg atctctcgct atcaataaag tggcctttta   4176

agaaa                                                               4181


<210>  6
<211>  1108
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly Trp Glu Glu Ala Arg 
1               5                   10                  15      


Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His Arg Asn Arg Thr Thr 
            20                  25                  30          


Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys Pro Leu Thr Phe Ala 
        35                  40                  45              


Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp Glu Glu Ala Tyr Asp 
    50                  55                  60                  


Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Gln 
65                  70                  75                  80  


Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu Gln Glu His Met Leu 
                85                  90                  95      


Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu Ser Ala Gln Lys Glu 
            100                 105                 110         


Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu Ala Gln Gln Glu Tyr 
        115                 120                 125             


Gln Gln Leu His Ala Val Trp Glu His Lys Leu Gly Ser Gln Val Ser 
    130                 135                 140                 


Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr Asp Pro Glu Ile Leu 
145                 150                 155                 160 


Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val Asn Lys Leu Lys Arg 
                165                 170                 175     


Glu Met Val His Leu Gln His Glu Leu Gln Phe Lys Glu Arg Gly Phe 
            180                 185                 190         


Gln Thr Leu Lys Lys Ile Asp Glu Arg Met Ser Asp Ala Gln Gly Gly 
        195                 200                 205             


Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg Glu Thr Lys Ala Ile 
    210                 215                 220                 


Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu Ile Lys 
225                 230                 235                 240 


Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly Ser His 
                245                 250                 255     


Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser Phe Pro 
            260                 265                 270         


Val Pro Lys Gln Phe Leu Asp Val Ser Ser Gln Thr Asp Ile Ser Gly 
        275                 280                 285             


Ser Phe Ser Thr Ser Ser Ser Asn Gln Leu Ala Glu Lys Val Arg Leu 
    290                 295                 300                 


Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu Lys Ile 
305                 310                 315                 320 


Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu Asp Ser 
                325                 330                 335     


Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu Leu Lys 
            340                 345                 350         


Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu Val Glu 
        355                 360                 365             


Gln Leu Glu Met Ala Arg Arg Arg Leu Glu Lys Asp Leu Gln Ala Ala 
    370                 375                 380                 


Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu Asn Ser 
385                 390                 395                 400 


Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg Gln Val 
                405                 410                 415     


Ala Ala Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met Gln Ser 
            420                 425                 430         


Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg Gly Ser 
        435                 440                 445             


Leu Ala Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe Thr Asp 
    450                 455                 460                 


Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Pro Ser Lys 
465                 470                 475                 480 


Val Glu Leu Leu Phe Leu Glu Gly Ala Thr Gly Phe Arg Pro Ser Gly 
                485                 490                 495     


Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln Lys Ala 
            500                 505                 510         


Glu Gly Gly Ser Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly Thr Pro 
        515                 520                 525             


Arg Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser Pro Ser 
    530                 535                 540                 


Pro Pro Cys Ser Pro Leu Ile Ala Asp Pro Leu Leu Ala Gly Asp Ala 
545                 550                 555                 560 


Phe Leu Thr Pro Leu Glu Phe Glu Asp Thr Glu Leu Ser Pro Thr Leu 
                565                 570                 575     


Cys Glu Leu Ser Leu Gly Thr Asp Gly Ala Arg Glu Arg Phe Arg Leu 
            580                 585                 590         


Glu Glu Pro Gly Pro Glu Gly Lys Pro Leu Gly Gln Ala Ala Ser Val 
        595                 600                 605             


Ala Pro Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val Ser 
    610                 615                 620                 


Asp Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Met Gln 
625                 630                 635                 640 


Arg Leu Gly Thr Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser Glu 
                645                 650                 655     


Ala Val Gly Val Thr Gln Val Gln Ile Ala Leu Lys Tyr Asp Glu Lys 
            660                 665                 670         


Ser Lys Gln Phe Ala Ile Leu Val Ile Gln Leu Ser Asn Leu Ser Ala 
        675                 680                 685             


Leu Leu Leu Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Ile Leu 
    690                 695                 700                 


Pro Cys Ser Glu Ser Ser Thr Cys Leu Phe Arg Thr Arg Pro Leu Asp 
705                 710                 715                 720 


Ser Ala Asp Ser Leu Val Phe Asn Glu Ala Phe Trp Val Ser Met Ser 
                725                 730                 735     


Tyr Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr Thr 
            740                 745                 750         


Asp Arg Ser His Thr Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser Leu 
        755                 760                 765             


Ala Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn Leu 
    770                 775                 780                 


Leu Ser Tyr Lys Tyr Leu Lys Lys Gln Gly Arg Glu Pro Gln Pro Ala 
785                 790                 795                 800 


Glu Ala Pro Gly Pro Asp His Val Asp Ala Val Ser Ala Leu Leu Glu 
                805                 810                 815     


Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu Gly Arg Ser Ser Ser 
            820                 825                 830         


Gln Thr Leu Glu Gly Ser Trp Thr Tyr Glu Glu Glu Ala Ser Glu Asn 
        835                 840                 845             


Glu Ala Val Ala Glu Glu Glu Glu Arg Glu Glu Glu Glu Gly Glu Glu 
    850                 855                 860                 


Asp Val Phe Ala Glu Lys Val Ser Pro Glu Ala Glu Glu Cys Pro Ala 
865                 870                 875                 880 


Leu Lys Val Asp Arg Glu Thr Asn Thr Asp Ser Val Thr Pro Ser Pro 
                885                 890                 895     


Thr Val Val Arg Pro Lys Asp Arg Arg Val Gly Ala Pro Ser Pro Gly 
            900                 905                 910         


Pro Phe Leu Arg Gly Asn Thr Ile Ile Arg Ser Lys Thr Phe Ser Pro 
        915                 920                 925             


Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu Asn Arg Ser Asp Ser Asp 
    930                 935                 940                 


Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe Val Arg Asn Ser Leu Glu 
945                 950                 955                 960 


Arg Arg Ser Val Arg Met Lys Arg Pro Ser Ser Val Lys Ser Leu Arg 
                965                 970                 975     


Thr Glu Arg Leu Ile Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu Gln 
            980                 985                 990         


Ala Thr Arg Thr Trp His Ser Gln  Leu Thr Gln Glu Ile  Ser Val Leu 
        995                 1000                 1005             


Lys Glu  Leu Lys Glu His Leu  Glu Gln Ala Lys Asn  His Gly Glu 
    1010                 1015                 1020             


Lys Glu  Leu Pro Gln Trp Leu  Arg Glu Asp Glu Arg  Phe Arg Leu 
    1025                 1030                 1035             


Leu Leu  Arg Met Leu Glu Lys  Arg Val Asp Arg Gly  Glu His Lys 
    1040                 1045                 1050             


Ser Glu  Leu Gln Ala Asp Lys  Met Met Arg Ala Ala  Ala Lys Asp 
    1055                 1060                 1065             


Val His  Arg Leu Arg Gly Gln  Ser Cys Lys Glu Pro  Pro Glu Val 
    1070                 1075                 1080             


Gln Ser  Phe Arg Glu Lys Met  Ala Phe Phe Thr Arg  Pro Arg Met 
    1085                 1090                 1095             


Asn Ile  Pro Ala Leu Ser Ala  Asp Asp Val 
    1100                 1105             



<210>  7
<211>  4171
<212>  DNA
<213>  Homo sapiens

<400>  7
ctggagccgc tgagcccccg ctgcggccgg gagctgcatg ggggagcgcc ggcagcgctt     60

gggaagatgc cccggccgga gctgcccctg ccggagggct gggaggaggc gcgcgacttc    120

gacggcaagg tctactacat agaccacacg aaccgcacca ccagctggat cgacccgcgg    180

gacaggtaca ccaaaccgct cacctttgct gactgcatta gtgatgagtt gccgctagga    240

tgggaagagg catatgaccc acaggttgga gattacttca tagaccacaa caccaaaacc    300

actcagattg aggatcctcg agtacaatgg cggcgggagc aggaacatat gctgaaggat    360

tacctggtgg tggcccagga ggctctgagt gcacaaaagg agatctacca ggtgaagcag    420

cagcgcctgg agcttgcaca gcaggagtac cagcaactgc atgccgtctg ggagcataag    480

ctgggctccc aggtcagctt ggtctctggt tcatcatcca gctccaagta tgaccctgag    540

atcctgaaag ctgaaattgc cactgcaaaa tcccgggtca acaagctgaa gagagagatg    600

gttcacctcc agcacgagct gcagttcaaa gagcgtggct ttcagaccct gaagaaaatc    660

gataagaaaa tgtctgatgc tcagggcagc tacaaactgg atgaagctca ggctgtcttg    720

agagaaacaa aagccatcaa aaaggctatt acctgtgggg aaaaggaaaa gcaagatctc    780

attaagagcc ttgccatgtt gaaggacggc ttccgcactg acagggggtc tcactcagac    840

ctgtggtcca gcagcagctc tctggagagt tcgagtttcc cgctaccgaa acagtacctg    900

gatgtgagct cccagacaga catctcggga agcttcggca tcaacagcaa caatcagttg    960

gcagagaagg tcagattgcg ccttcgatat gaagaggcta agagaaggat cgccaacctg   1020

aagatccagc tggccaagct tgacagtgag gcctggcctg gggtgctgga ctcagagagg   1080

gaccggctga tccttatcaa cgagaaggag gagctgctga aggagatgcg cttcatcagc   1140

ccccgcaagt ggacccaggg ggaggtggag cagctggaga tggcccggaa gcggctggaa   1200

aaggacctgc aggcagcccg ggacacccag agcaaggcgc tgacggagag gttaaagtta   1260

aacagtaaga ggaaccagct tgtgagagaa ctggaggaag ccacccggca ggtggcaact   1320

ctgcactccc agctgaaaag tctctcaagc agcatgcagt ccctgtcctc aggcagcagc   1380

cccggatccc tcacgtccag ccggggctcc ctggttgcat ccagcctgga ctcctccact   1440

tcagccagct tcactgacct ctactatgac ccctttgagc agctggactc agagctgcag   1500

agcaaggtgg agttcctgct cctggagggg gccaccggct tccggccctc aggctgcatc   1560

accaccatcc acgaggatga ggtggccaag acccagaagg cagagggagg tggccgcctg   1620

caggctctgc gttccctgtc tggcacccca aagtccatga cctccctatc cccacgttcc   1680

tctctctcct ccccctcccc accctgttcc cctctcatgg ctgaccccct cctggctggt   1740

gatgccttcc tcaactcctt ggagtttgaa gacccggagc tgagtgccac tctttgtgaa   1800

ctgagccttg gtaacagcgc ccaggaaaga taccggctgg aggaaccagg aacggagggc   1860

aagcagctgg gccaagctgt gaatacggcc caggggtgtg gcctgaaagt ggcctgtgtc   1920

tcagccgccg tatcggacga gtcagtggct ggagacagtg gtgtgtacga ggcttccgtg   1980

cagagactgg gtgcttcaga agctgctgca tttgacagtg acgaatcgga agcagtgggt   2040

gcgacccgaa ttcagattgc cctgaagtat gatgagaaga ataagcaatt tgcaatatta   2100

atcatccagc tgagtaacct ttctgctctg ttgcagcaac aagaccagaa agtgaatatc   2160

cgcgtggctg tccttccttg ctctgaaagc acaacctgcc tgttccggac ccggcctctg   2220

gacgcctcag acactctagt gttcaatgag gtgttctggg tatccatgtc ctatccagcc   2280

cttcaccaga agaccttaag agtcgatgtc tgtaccaccg acaggagcca tctggaagag   2340

tgcctgggag gcgcccagat cagcctggcg gaggtctgcc ggtctgggga gaggtcgact   2400

cgctggtaca accttctcag ctacaaatac ttgaagaagc agagcaggga gctcaagcca   2460

gtgggagtta tggcccctgc ctcagggcct gccagcacgg acgctgtgtc tgctctgttg   2520

gaacagacag cagtggagct ggagaagagg caggagggca ggagcagcac acagacactg   2580

gaagacagct ggaggtatga ggagaccagt gagaatgagg cagtagccga ggaagaggag   2640

gaggaggtgg aggaggagga gggagaagag gatgttttca ccgagaaagc ctcacctgat   2700

atggatgggt acccagcatt aaaggtggac aaagagacca acacggagac cccggcccca   2760

tcccccacag tggtgcgacc taaggaccgg agagtgggca ccccgtccca ggggccattt   2820

cttcgaggga gcaccatcat ccgctctaag accttctccc caggacccca gagccagtac   2880

gtgtgccggc tgaatcggag tgatagtgac agctccactc tgtccaaaaa gccacctttt   2940

gttcgaaact ccctggagcg acgcagcgtc cggatgaagc ggccttcctc ggtcaagtcg   3000

ctgcgctccg agcgtctgat ccgtacctcg ctggacctgg agttagacct gcaggcgaca   3060

agaacctggc acagccaact gacccaggag atctcggtgc tgaaggagct caaggagcag   3120

ctggaacaag ccaagagcca cggggagaag gagctgccac agtggttgcg tgaggacgag   3180

cgtttccgcc tgctgctgag gatgctggag aagcggcaga tggaccgagc ggagcacaag   3240

ggtgagcttc agacagacaa gatgatgagg gcagctgcca aggatgtgca caggctccga   3300

ggccagagct gtaaggaacc cccagaagtt cagtctttca gggagaagat ggcatttttc   3360

acccggcctc ggatgaatat cccagctctc tctgcagatg acgtctaatc gccagaaaag   3420

tatttccttt gttccactga ccaggctgtg aacattgact gtggctaaag ttatttatgt   3480

ggtgttatat gaaggtactg agtcacaagt cctctagtgc tcttgttggt ttgaagatga   3540

accgactttt tagtttgggt cctactgttg ttattaaaaa cagaacaaaa acaaaacaca   3600

cacacacaca aaaacagaaa caaaaaaaac cagcattaaa ataataagat tgtatagttt   3660

gtatatttag gagtgtattt ttgggaaaga aaatttaaat gaactaaagc agtattgagt   3720

tgctgctctt cttaaaatcg tttagatttt ttttggtttg tacagctcca ccttttagag   3780

gtcttactgc aataagaagt aatgcctggg ggacggtaat cctaatagga cgtcccgcac   3840

ttgtcacagt acagctaatt tttcctagtt aacatatttt gtacaatatt aaaaaaatgc   3900

acagaaacca ttggggggga ttcagaggtg catccacgga tcttcttgag ctgtgacgtg   3960

tttttatgtg gctgcccaac gtggagcggg cagtgtgata ggctgggtgg gctaagcagc   4020

ctagtctatg tgggtgacag gccacgctgg tctcagatgc ccagtgaagc cactaacatg   4080

agtgagggga gggctgtggg gaactccatt cagttttatc tccatcaata aagtggcctt   4140

tcaaaaagaa aaaaaaaaaa aaaaaaaaaa a                                  4171


