                         SEQUENCE LISTING

<110>  Lira, Justin
       Narva, Kenneth
       Woosley, Aaron
       Larrinua, Ignacio
       Hey, Timothy

 
<120>  DIG-11 Insecticidal proteins

<130>  68095

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3492
<212>  DNA
<213>  Bacillus thuringiensis

<400>  1
atgaattgtg gagaccataa tgaattcgat attatagatg taattgaaaa caaccagact       60

aaagcatcac gacatgttaa tgagtcagac aatgtaaata gacaaaggaa tttatctaat      120

acgatttttt ctaatctatc ttctaattat cctctagcaa gcaatccaaa tacaccattt      180

caaaatatga attataaaga atatctgaat attactgaag gggggattat taacccgacc      240

cttgcgggga gcgctattgt agttgcgcag aatgttagta agacaatcct taaaaaatta      300

gggagtacaa ttttggggaa gattcttggt agtgttctag atattttatg gccaactaat      360

actgaagaaa tatggttgga attaatagat gaggtagaag aactgattaa tcaaaaaata      420

gagcaacagg taataattga tgcagaaaca gctttagagt cagtaaaatt aaatgttgat      480

ttatatttaa atgcacttgc agaatgggaa acaagaccta ctaatgaata cagtacagaa      540

ctggtctata aaaggtttac tgatgcatat aattatgcgc gaactagtat gccatttttt      600

agtgttcgaa cttatgaagt ttctctatta tcagtgtatg cacaagctgc taatattagt      660

ttgcttttat cgagagatgc gcaaatatat ggagatttgt ggggatttga cgaacatgac      720

aaagccactt ttgatggtga acgaaaatta tttagagctg aatatataga tcattgcact      780

aaatattata aagttggact tgatagacta aaaggatctt cttacgaatc ttgggtaaat      840

tataatcgtt atcgtagaga aatgacatta atgatattag ataccatagc agcattccca      900

tattatgaca ttgaagagta cccaatagag gttagtactc agttagcaag agaggtttat      960

actgatccaa taataacgtc atttgttgaa tcagatcatg gaccaagttt ttctttcatg     1020

gaaagtaacg caattcgaaa accacacctt gttgattatt tagataatct ttatatatat     1080

acatcgagat tcagaacatt ttcaaatgaa tttcaacctg atctaaatta ttgggctgct     1140

cataaagtca aatataaata ttctggggat cctactttac atgaaacacc catatatggt     1200

aatgcatcta attatgaaag tacagggaac tactcattta gaggtaatag tatttatcaa     1260

acgttatcag ctccttctgc aatacttaca cccaattaca tctattatgg tatagagcaa     1320

gttgagtttt atggtaacaa aggtaatgta tattatagag gaggtaataa ataccctctg     1380

agtgtggatt ctgctaatca attaccacca gatgtagaac caataacaga aaattacaat     1440

catgttttat gtcatgctac agctgtgcct gtaaaagatg gtggtacagt tcctattttt     1500

tcttggacac atagaagtgc ggattattat aataccattt atccagataa gattacgcaa     1560

cttcctgcag tcaaaagcac tccttctcca gaagtggaag ggcttaaagt gcaagaaggt     1620

ccaggcttta caggtggaga tcttgttgta gcaaaatcaa gtaatcaaac tattgttagg     1680

ttaaaggtta cggtagattc tccgggaaca caaaagtatc gtataagact aaaatatgcg     1740

gctactagta atttttatct aggtgcttat gcaggaagta atggggggaa cggaattcca     1800

ggtatcagta ctgttcctaa aacaatgaat atagaagatc ctctttcata tacttcattt     1860

gcttatattg atttacctga ttcatatact tttagtcaaa aagacgaggt tataagattc     1920

actataaata tatacgaatc aggcggagcc gtatatgcag acaaagttga atttatcccc     1980

gtggatgctg attacgatga aggagttcaa ttggaaaaag cacagaaagc cgtgaatgcc     2040

ttgtttacag cgggaagaaa cgcactacaa acagatgtga cagattacaa agtagatcag     2100

gtgtcaattt tagtggattg tgtatcaggg gagttatacc ccaatgagaa acgcgaacta     2160

caaaatctaa tcaaatacgc aaaacgtttg agctattccc gtaatttact cctagatcca     2220

acattcgatt ctatcaattc atcagatgag aatggctggt acggaagtaa tggtattgca     2280

atcggcagtg ggaatattgt attcaaaggg aactacttaa ttttctcagg taccaatgat     2340

gaacaatatc caacctatct ctatcaaaaa atagacgaat ctaagttaaa agaatataca     2400

cgttataaac tgagaggttt tatcgagagt agtcaggatt tagaagcata cgtgattcgt     2460

tatgatgcaa aacatcaaac aatggatgta tccaataatc tattctcaga tattactcct     2520

gtaaatgcat gcggagaacc aaatcgttgt gcggcactac catacctgga tgaaaatcca     2580

agattagaat gtagttcgat acaagatgga attctatctg attcgcattc gttttctctc     2640

catatagata caggttctat tgatttcaat gagaacgtag gcatttgggt gttgtttaaa     2700

atttccacac tagaaggata cgcgaaattt gggaacctag aagtgattga agatggccca     2760

gtcattggag aagcattagc ccgtgtgaaa cgccaagaaa cgaagtggag aaacaagttg     2820

acacaactgc gaacggaaac acaagcgatt tatacaagag caaaacaagc cattgataat     2880

ttattcacaa atgaacagga ctctcactta aaaataggta cgacatttgc gtcaattgtg     2940

gctgcacgaa agattgtcca atccatacgt gaagcgtata tgtcatggtt atctatcgtc     3000

ccaggtgtaa attatcctat ttttacagaa ttgaatgaga gagtacagca agcatttcaa     3060

ttatatgatg tacgaaatgt cgtgcgtaat ggccgattcc agagtggaac atctgattgg     3120

attgtaacct ctgacgtaaa ggtacaagaa gaaaatggga ataacgtatt agttctttcc     3180

aattgggatg cgcaagtatt acaatgcatg acgctctacc aagaccgtgg gtatatctta     3240

cgcgtaacag cacgtaagga aggactgggc gaagggtatg taacaatcac tgatgaagaa     3300

ggaaatacag atcaattgag atttggtgga tgtgaggaga tagatgcatc taactcgttc     3360

gtatccacag gttatgttac aaaagaacta gaatttttcc cagatacaga gaaagtgcgt     3420

atagaaattg gagaaacaga aggaatattc caggtgggaa gtgtagaatt atttttgatg     3480

gaagatctat gt                                                         3492


<210>  2
<211>  1164
<212>  PRT
<213>  Bacillus thuringiensis

<400>  2

Met Asn Cys Gly Asp His Asn Glu Phe Asp Ile Ile Asp Val Ile Glu 
1               5                   10                  15      


Asn Asn Gln Thr Lys Ala Ser Arg His Val Asn Glu Ser Asp Asn Val 
            20                  25                  30          


Asn Arg Gln Arg Asn Leu Ser Asn Thr Ile Phe Ser Asn Leu Ser Ser 
        35                  40                  45              


Asn Tyr Pro Leu Ala Ser Asn Pro Asn Thr Pro Phe Gln Asn Met Asn 
    50                  55                  60                  


Tyr Lys Glu Tyr Leu Asn Ile Thr Glu Gly Gly Ile Ile Asn Pro Thr 
65                  70                  75                  80  


Leu Ala Gly Ser Ala Ile Val Val Ala Gln Asn Val Ser Lys Thr Ile 
                85                  90                  95      


Leu Lys Lys Leu Gly Ser Thr Ile Leu Gly Lys Ile Leu Gly Ser Val 
            100                 105                 110         


Leu Asp Ile Leu Trp Pro Thr Asn Thr Glu Glu Ile Trp Leu Glu Leu 
        115                 120                 125             


Ile Asp Glu Val Glu Glu Leu Ile Asn Gln Lys Ile Glu Gln Gln Val 
    130                 135                 140                 


Ile Ile Asp Ala Glu Thr Ala Leu Glu Ser Val Lys Leu Asn Val Asp 
145                 150                 155                 160 


Leu Tyr Leu Asn Ala Leu Ala Glu Trp Glu Thr Arg Pro Thr Asn Glu 
                165                 170                 175     


Tyr Ser Thr Glu Leu Val Tyr Lys Arg Phe Thr Asp Ala Tyr Asn Tyr 
            180                 185                 190         


Ala Arg Thr Ser Met Pro Phe Phe Ser Val Arg Thr Tyr Glu Val Ser 
        195                 200                 205             


Leu Leu Ser Val Tyr Ala Gln Ala Ala Asn Ile Ser Leu Leu Leu Ser 
    210                 215                 220                 


Arg Asp Ala Gln Ile Tyr Gly Asp Leu Trp Gly Phe Asp Glu His Asp 
225                 230                 235                 240 


Lys Ala Thr Phe Asp Gly Glu Arg Lys Leu Phe Arg Ala Glu Tyr Ile 
                245                 250                 255     


Asp His Cys Thr Lys Tyr Tyr Lys Val Gly Leu Asp Arg Leu Lys Gly 
            260                 265                 270         


Ser Ser Tyr Glu Ser Trp Val Asn Tyr Asn Arg Tyr Arg Arg Glu Met 
        275                 280                 285             


Thr Leu Met Ile Leu Asp Thr Ile Ala Ala Phe Pro Tyr Tyr Asp Ile 
    290                 295                 300                 


Glu Glu Tyr Pro Ile Glu Val Ser Thr Gln Leu Ala Arg Glu Val Tyr 
305                 310                 315                 320 


Thr Asp Pro Ile Ile Thr Ser Phe Val Glu Ser Asp His Gly Pro Ser 
                325                 330                 335     


Phe Ser Phe Met Glu Ser Asn Ala Ile Arg Lys Pro His Leu Val Asp 
            340                 345                 350         


Tyr Leu Asp Asn Leu Tyr Ile Tyr Thr Ser Arg Phe Arg Thr Phe Ser 
        355                 360                 365             


Asn Glu Phe Gln Pro Asp Leu Asn Tyr Trp Ala Ala His Lys Val Lys 
    370                 375                 380                 


Tyr Lys Tyr Ser Gly Asp Pro Thr Leu His Glu Thr Pro Ile Tyr Gly 
385                 390                 395                 400 


Asn Ala Ser Asn Tyr Glu Ser Thr Gly Asn Tyr Ser Phe Arg Gly Asn 
                405                 410                 415     


Ser Ile Tyr Gln Thr Leu Ser Ala Pro Ser Ala Ile Leu Thr Pro Asn 
            420                 425                 430         


Tyr Ile Tyr Tyr Gly Ile Glu Gln Val Glu Phe Tyr Gly Asn Lys Gly 
        435                 440                 445             


Asn Val Tyr Tyr Arg Gly Gly Asn Lys Tyr Pro Leu Ser Val Asp Ser 
    450                 455                 460                 


Ala Asn Gln Leu Pro Pro Asp Val Glu Pro Ile Thr Glu Asn Tyr Asn 
465                 470                 475                 480 


His Val Leu Cys His Ala Thr Ala Val Pro Val Lys Asp Gly Gly Thr 
                485                 490                 495     


Val Pro Ile Phe Ser Trp Thr His Arg Ser Ala Asp Tyr Tyr Asn Thr 
            500                 505                 510         


Ile Tyr Pro Asp Lys Ile Thr Gln Leu Pro Ala Val Lys Ser Thr Pro 
        515                 520                 525             


Ser Pro Glu Val Glu Gly Leu Lys Val Gln Glu Gly Pro Gly Phe Thr 
    530                 535                 540                 


Gly Gly Asp Leu Val Val Ala Lys Ser Ser Asn Gln Thr Ile Val Arg 
545                 550                 555                 560 


Leu Lys Val Thr Val Asp Ser Pro Gly Thr Gln Lys Tyr Arg Ile Arg 
                565                 570                 575     


Leu Lys Tyr Ala Ala Thr Ser Asn Phe Tyr Leu Gly Ala Tyr Ala Gly 
            580                 585                 590         


Ser Asn Gly Gly Asn Gly Ile Pro Gly Ile Ser Thr Val Pro Lys Thr 
        595                 600                 605             


Met Asn Ile Glu Asp Pro Leu Ser Tyr Thr Ser Phe Ala Tyr Ile Asp 
    610                 615                 620                 


Leu Pro Asp Ser Tyr Thr Phe Ser Gln Lys Asp Glu Val Ile Arg Phe 
625                 630                 635                 640 


Thr Ile Asn Ile Tyr Glu Ser Gly Gly Ala Val Tyr Ala Asp Lys Val 
                645                 650                 655     


Glu Phe Ile Pro Val Asp Ala Asp Tyr Asp Glu Gly Val Gln Leu Glu 
            660                 665                 670         


Lys Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ala Gly Arg Asn Ala 
        675                 680                 685             


Leu Gln Thr Asp Val Thr Asp Tyr Lys Val Asp Gln Val Ser Ile Leu 
    690                 695                 700                 


Val Asp Cys Val Ser Gly Glu Leu Tyr Pro Asn Glu Lys Arg Glu Leu 
705                 710                 715                 720 


Gln Asn Leu Ile Lys Tyr Ala Lys Arg Leu Ser Tyr Ser Arg Asn Leu 
                725                 730                 735     


Leu Leu Asp Pro Thr Phe Asp Ser Ile Asn Ser Ser Asp Glu Asn Gly 
            740                 745                 750         


Trp Tyr Gly Ser Asn Gly Ile Ala Ile Gly Ser Gly Asn Ile Val Phe 
        755                 760                 765             


Lys Gly Asn Tyr Leu Ile Phe Ser Gly Thr Asn Asp Glu Gln Tyr Pro 
    770                 775                 780                 


Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Glu Tyr Thr 
785                 790                 795                 800 


Arg Tyr Lys Leu Arg Gly Phe Ile Glu Ser Ser Gln Asp Leu Glu Ala 
                805                 810                 815     


Tyr Val Ile Arg Tyr Asp Ala Lys His Gln Thr Met Asp Val Ser Asn 
            820                 825                 830         


Asn Leu Phe Ser Asp Ile Thr Pro Val Asn Ala Cys Gly Glu Pro Asn 
        835                 840                 845             


Arg Cys Ala Ala Leu Pro Tyr Leu Asp Glu Asn Pro Arg Leu Glu Cys 
    850                 855                 860                 


Ser Ser Ile Gln Asp Gly Ile Leu Ser Asp Ser His Ser Phe Ser Leu 
865                 870                 875                 880 


His Ile Asp Thr Gly Ser Ile Asp Phe Asn Glu Asn Val Gly Ile Trp 
                885                 890                 895     


Val Leu Phe Lys Ile Ser Thr Leu Glu Gly Tyr Ala Lys Phe Gly Asn 
            900                 905                 910         


Leu Glu Val Ile Glu Asp Gly Pro Val Ile Gly Glu Ala Leu Ala Arg 
        915                 920                 925             


Val Lys Arg Gln Glu Thr Lys Trp Arg Asn Lys Leu Thr Gln Leu Arg 
    930                 935                 940                 


Thr Glu Thr Gln Ala Ile Tyr Thr Arg Ala Lys Gln Ala Ile Asp Asn 
945                 950                 955                 960 


Leu Phe Thr Asn Glu Gln Asp Ser His Leu Lys Ile Gly Thr Thr Phe 
                965                 970                 975     


Ala Ser Ile Val Ala Ala Arg Lys Ile Val Gln Ser Ile Arg Glu Ala 
            980                 985                 990         


Tyr Met Ser Trp Leu Ser Ile Val  Pro Gly Val Asn Tyr  Pro Ile Phe 
        995                 1000                 1005             


Thr Glu  Leu Asn Glu Arg Val  Gln Gln Ala Phe Gln  Leu Tyr Asp 
    1010                 1015                 1020             


Val Arg  Asn Val Val Arg Asn  Gly Arg Phe Gln Ser  Gly Thr Ser 
    1025                 1030                 1035             


Asp Trp  Ile Val Thr Ser Asp  Val Lys Val Gln Glu  Glu Asn Gly 
    1040                 1045                 1050             


Asn Asn  Val Leu Val Leu Ser  Asn Trp Asp Ala Gln  Val Leu Gln 
    1055                 1060                 1065             


Cys Met  Thr Leu Tyr Gln Asp  Arg Gly Tyr Ile Leu  Arg Val Thr 
    1070                 1075                 1080             


Ala Arg  Lys Glu Gly Leu Gly  Glu Gly Tyr Val Thr  Ile Thr Asp 
    1085                 1090                 1095             


Glu Glu  Gly Asn Thr Asp Gln  Leu Arg Phe Gly Gly  Cys Glu Glu 
    1100                 1105                 1110             


Ile Asp  Ala Ser Asn Ser Phe  Val Ser Thr Gly Tyr  Val Thr Lys 
    1115                 1120                 1125             


Glu Leu  Glu Phe Phe Pro Asp  Thr Glu Lys Val Arg  Ile Glu Ile 
    1130                 1135                 1140             


Gly Glu  Thr Glu Gly Ile Phe  Gln Val Gly Ser Val  Glu Leu Phe 
    1145                 1150                 1155             


Leu Met  Glu Asp Leu Cys 
    1160                 


<210>  3
<211>  1992
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic molecule

<400>  3
atgaactgtg gcgaccacaa tgagtttgat atcatcgacg tcatcgaaaa caaccagacc       60

aaggcctcca gacacgtgaa tgagagcgac aatgtcaaca gacagcgcaa cctttctaac      120

acgatcttct ctaacttgtc gtccaactat cctctcgcga gcaatccgaa caccccattc      180

cagaacatga actacaagga gtatctcaac atcaccgagg gtggcatcat caatccgaca      240

ctggctggca gcgctatcgt tgtggcacag aacgtgtcca agacaatact gaagaagttg      300

ggaagcacca tcctcggaaa gatcctcggc agcgtccttg atatcttgtg gccaacgaac      360

accgaggaaa tctggcttga actcattgat gaggttgagg aactgatcaa tcagaagatt      420

gagcagcaag tcatcattga cgcagagaca gccctcgaat ctgtgaaact gaatgtggac      480

ctctatctga acgctctggc agagtgggag acgagaccga ccaatgagta ctccaccgag      540

ttggtctaca aacgcttcac agacgcctac aactatgcga ggacctcgat gccgttcttt      600

tcagtgagga cttacgaggt gtctctgctc tctgtctatg cccaagctgc caacatatcg      660

ctgctccttt ccagagatgc ccaaatctat ggcgatcttt ggggattcga cgaacatgac      720

aaggcgacat tcgatgggga gcggaagctg tttagggcag agtacatcga ccactgcacg      780

aagtactaca aagttgggct tgacagactg aaaggcagct catacgagtc atgggttaac      840

tacaatcgct acagacggga gatgacgttg atgattctgg acacaatagc agcctttccc      900

tactacgaca tcgaggagta tcccattgag gtgtcaaccc agctggctag ggaggtctac      960

accgacccga tcattacttc ctttgtggaa tccgatcatg gtccgtcgtt ttccttcatg     1020

gaatcgaacg ccataaggaa accccacctc gttgactatc ttgacaatct ctacatctac     1080

accagcagat tccgcacttt cagcaatgag ttccagccag acctcaacta ctgggctgcc     1140

cacaaggtca agtacaagta ctctggcgac ccaaccttgc acgagacacc catctacgga     1200

aatgcctcaa actatgagag cactggcaac tactccttta ggggaaactc gatctatcag     1260

accctctcgg ctccgtctgc cattcttacg cctaactaca tctactacgg gatagagcaa     1320

gtggagttct acgggaacaa gggcaacgtc tactataggg gtggcaacaa gtatccgctg     1380

tcagttgact cggcaaacca gttgcctccc gacgttgagc ctatcacgga gaactacaat     1440

catgtccttt gccacgccac agccgttccc gtcaaggatg gtggcaccgt gcctatcttt     1500

tcatggactc atcggtccgc tgactactac aatacgatct atcctgataa gataacccag     1560

cttccagcgg tgaagagcac gccttcacca gaggtggagg gtctcaaagt ccaagaagga     1620

cctggcttca ctggtgggga tttggttgtc gcgaagtcca gcaatcagac catcgtcaga     1680

ctgaaagtga cagtggattc tcctggcacg cagaagtaca gaatcagact gaagtacgct     1740

gcgacctcaa acttctatct gggagcctac gctgggtcca atggtggcaa cgggattcct     1800

ggcatctcca ctgttccaaa gactatgaac attgaagatc ccctctctta cacgagcttt     1860

gcgtacattg atttgccaga cagctacact ttctcacaaa aggacgaagt gatacgcttc     1920

actatcaaca tctacgaatc gggtggagcg gtgtacgctg acaaggtcga gttcatccca     1980

gtggatgcag ac                                                         1992


<210>  4
<211>  545
<212>  PRT
<213>  Bacillus thuringiensis

<400>  4

Leu Glu Ala Glu Ser Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala 
1               5                   10                  15      


Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu Lys Thr Asp Val Thr Asp 
            20                  25                  30          


Tyr His Ile Asp Arg Val Ser Asn Leu Val Glu Cys Leu Ser Asp Glu 
        35                  40                  45              


Phe Cys Leu Asp Glu Lys Lys Glu Leu Ser Glu Lys Val Lys His Ala 
    50                  55                  60                  


Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe Arg 
65                  70                  75                  80  


Gly Ile Asn Arg Gln Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile 
                85                  90                  95      


Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu 
            100                 105                 110         


Leu Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile 
        115                 120                 125             


Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg Tyr Gln Leu Arg Gly Tyr 
    130                 135                 140                 


Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala 
145                 150                 155                 160 


Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu 
                165                 170                 175     


Ser Ala Pro Ser Pro Ile Gly Lys Cys Ala His His Ser His His Phe 
            180                 185                 190         


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
        195                 200                 205             


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
    210                 215                 220                 


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
225                 230                 235                 240 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
                245                 250                 255     


Leu Glu Trp Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
            260                 265                 270         


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
        275                 280                 285             


Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
    290                 295                 300                 


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
305                 310                 315                 320 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr 
                325                 330                 335     


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
            340                 345                 350         


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
        355                 360                 365             


Arg Ser Val Leu Val Val Pro Glu Trp Glu Ala Glu Val Ser Gln Glu 
    370                 375                 380                 


Val Arg Val Cys Pro Gly Arg Gly Tyr Ile Leu Arg Val Thr Ala Tyr 
385                 390                 395                 400 


Lys Glu Gly Tyr Gly Glu Gly Cys Val Thr Ile His Glu Ile Glu Asn 
                405                 410                 415     


Asn Thr Asp Glu Leu Lys Phe Ser Asn Cys Val Glu Glu Glu Val Tyr 
            420                 425                 430         


Pro Asn Asn Thr Val Thr Cys Asn Asp Tyr Thr Ala Thr Gln Glu Glu 
        435                 440                 445             


Tyr Glu Gly Thr Tyr Thr Ser Arg Asn Arg Gly Tyr Asp Gly Ala Tyr 
    450                 455                 460                 


Glu Ser Asn Ser Ser Val Pro Ala Asp Tyr Ala Ser Ala Tyr Glu Glu 
465                 470                 475                 480 


Lys Ala Tyr Thr Asp Gly Arg Arg Asp Asn Pro Cys Glu Ser Asn Arg 
                485                 490                 495     


Gly Tyr Gly Asp Tyr Thr Pro Leu Pro Ala Gly Tyr Val Thr Lys Glu 
            500                 505                 510         


Leu Glu Tyr Phe Pro Glu Thr Asp Lys Val Trp Ile Glu Ile Gly Glu 
        515                 520                 525             


Thr Glu Gly Thr Phe Ile Val Asp Ser Val Glu Leu Leu Leu Met Glu 
    530                 535                 540                 


Glu 
545 


<210>  5
<211>  1209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic molecule

<400>  5

Met Asn Cys Gly Asp His Asn Glu Phe Asp Ile Ile Asp Val Ile Glu 
1               5                   10                  15      


Asn Asn Gln Thr Lys Ala Ser Arg His Val Asn Glu Ser Asp Asn Val 
            20                  25                  30          


Asn Arg Gln Arg Asn Leu Ser Asn Thr Ile Phe Ser Asn Leu Ser Ser 
        35                  40                  45              


Asn Tyr Pro Leu Ala Ser Asn Pro Asn Thr Pro Phe Gln Asn Met Asn 
    50                  55                  60                  


Tyr Lys Glu Tyr Leu Asn Ile Thr Glu Gly Gly Ile Ile Asn Pro Thr 
65                  70                  75                  80  


Leu Ala Gly Ser Ala Ile Val Val Ala Gln Asn Val Ser Lys Thr Ile 
                85                  90                  95      


Leu Lys Lys Leu Gly Ser Thr Ile Leu Gly Lys Ile Leu Gly Ser Val 
            100                 105                 110         


Leu Asp Ile Leu Trp Pro Thr Asn Thr Glu Glu Ile Trp Leu Glu Leu 
        115                 120                 125             


Ile Asp Glu Val Glu Glu Leu Ile Asn Gln Lys Ile Glu Gln Gln Val 
    130                 135                 140                 


Ile Ile Asp Ala Glu Thr Ala Leu Glu Ser Val Lys Leu Asn Val Asp 
145                 150                 155                 160 


Leu Tyr Leu Asn Ala Leu Ala Glu Trp Glu Thr Arg Pro Thr Asn Glu 
                165                 170                 175     


Tyr Ser Thr Glu Leu Val Tyr Lys Arg Phe Thr Asp Ala Tyr Asn Tyr 
            180                 185                 190         


Ala Arg Thr Ser Met Pro Phe Phe Ser Val Arg Thr Tyr Glu Val Ser 
        195                 200                 205             


Leu Leu Ser Val Tyr Ala Gln Ala Ala Asn Ile Ser Leu Leu Leu Ser 
    210                 215                 220                 


Arg Asp Ala Gln Ile Tyr Gly Asp Leu Trp Gly Phe Asp Glu His Asp 
225                 230                 235                 240 


Lys Ala Thr Phe Asp Gly Glu Arg Lys Leu Phe Arg Ala Glu Tyr Ile 
                245                 250                 255     


Asp His Cys Thr Lys Tyr Tyr Lys Val Gly Leu Asp Arg Leu Lys Gly 
            260                 265                 270         


Ser Ser Tyr Glu Ser Trp Val Asn Tyr Asn Arg Tyr Arg Arg Glu Met 
        275                 280                 285             


Thr Leu Met Ile Leu Asp Thr Ile Ala Ala Phe Pro Tyr Tyr Asp Ile 
    290                 295                 300                 


Glu Glu Tyr Pro Ile Glu Val Ser Thr Gln Leu Ala Arg Glu Val Tyr 
305                 310                 315                 320 


Thr Asp Pro Ile Ile Thr Ser Phe Val Glu Ser Asp His Gly Pro Ser 
                325                 330                 335     


Phe Ser Phe Met Glu Ser Asn Ala Ile Arg Lys Pro His Leu Val Asp 
            340                 345                 350         


Tyr Leu Asp Asn Leu Tyr Ile Tyr Thr Ser Arg Phe Arg Thr Phe Ser 
        355                 360                 365             


Asn Glu Phe Gln Pro Asp Leu Asn Tyr Trp Ala Ala His Lys Val Lys 
    370                 375                 380                 


Tyr Lys Tyr Ser Gly Asp Pro Thr Leu His Glu Thr Pro Ile Tyr Gly 
385                 390                 395                 400 


Asn Ala Ser Asn Tyr Glu Ser Thr Gly Asn Tyr Ser Phe Arg Gly Asn 
                405                 410                 415     


Ser Ile Tyr Gln Thr Leu Ser Ala Pro Ser Ala Ile Leu Thr Pro Asn 
            420                 425                 430         


Tyr Ile Tyr Tyr Gly Ile Glu Gln Val Glu Phe Tyr Gly Asn Lys Gly 
        435                 440                 445             


Asn Val Tyr Tyr Arg Gly Gly Asn Lys Tyr Pro Leu Ser Val Asp Ser 
    450                 455                 460                 


Ala Asn Gln Leu Pro Pro Asp Val Glu Pro Ile Thr Glu Asn Tyr Asn 
465                 470                 475                 480 


His Val Leu Cys His Ala Thr Ala Val Pro Val Lys Asp Gly Gly Thr 
                485                 490                 495     


Val Pro Ile Phe Ser Trp Thr His Arg Ser Ala Asp Tyr Tyr Asn Thr 
            500                 505                 510         


Ile Tyr Pro Asp Lys Ile Thr Gln Leu Pro Ala Val Lys Ser Thr Pro 
        515                 520                 525             


Ser Pro Glu Val Glu Gly Leu Lys Val Gln Glu Gly Pro Gly Phe Thr 
    530                 535                 540                 


Gly Gly Asp Leu Val Val Ala Lys Ser Ser Asn Gln Thr Ile Val Arg 
545                 550                 555                 560 


Leu Lys Val Thr Val Asp Ser Pro Gly Thr Gln Lys Tyr Arg Ile Arg 
                565                 570                 575     


Leu Lys Tyr Ala Ala Thr Ser Asn Phe Tyr Leu Gly Ala Tyr Ala Gly 
            580                 585                 590         


Ser Asn Gly Gly Asn Gly Ile Pro Gly Ile Ser Thr Val Pro Lys Thr 
        595                 600                 605             


Met Asn Ile Glu Asp Pro Leu Ser Tyr Thr Ser Phe Ala Tyr Ile Asp 
    610                 615                 620                 


Leu Pro Asp Ser Tyr Thr Phe Ser Gln Lys Asp Glu Val Ile Arg Phe 
625                 630                 635                 640 


Thr Ile Asn Ile Tyr Glu Ser Gly Gly Ala Val Tyr Ala Asp Lys Val 
                645                 650                 655     


Glu Phe Ile Pro Val Asp Ala Asp Leu Glu Ala Glu Ser Asp Leu Glu 
            660                 665                 670         


Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile 
        675                 680                 685             


Gly Leu Lys Thr Asp Val Thr Asp Tyr His Ile Asp Arg Val Ser Asn 
    690                 695                 700                 


Leu Val Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Lys Glu 
705                 710                 715                 720 


Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Glu Arg Asn 
                725                 730                 735     


Leu Leu Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Leu Asp Arg 
            740                 745                 750         


Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val 
        755                 760                 765             


Phe Lys Glu Asn Tyr Val Thr Leu Leu Gly Thr Phe Asp Glu Cys Tyr 
    770                 775                 780                 


Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr 
785                 790                 795                 800 


Thr Arg Tyr Gln Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu 
                805                 810                 815     


Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro 
            820                 825                 830         


Gly Thr Gly Ser Leu Trp Pro Leu Ser Ala Pro Ser Pro Ile Gly Lys 
        835                 840                 845             


Cys Ala His His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys 
    850                 855                 860                 


Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys 
865                 870                 875                 880 


Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu 
                885                 890                 895     


Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys 
            900                 905                 910         


Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile Val 
        915                 920                 925             


Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln 
    930                 935                 940                 


Tyr Asp Arg Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala 
945                 950                 955                 960 


Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser 
                965                 970                 975     


Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg 
            980                 985                 990         


Ile Phe Thr Ala Phe Ser Leu Tyr  Asp Ala Arg Asn Val  Ile Lys Asn 
        995                 1000                 1005             


Gly Asp  Phe Asn Asn Gly Leu  Ser Cys Trp Asn Val  Lys Gly His 
    1010                 1015                 1020             


Val Asp  Val Glu Glu Gln Asn  Asn His Arg Ser Val  Leu Val Val 
    1025                 1030                 1035             


Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu Val Arg  Val Cys Pro 
    1040                 1045                 1050             


Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala Tyr Lys  Glu Gly Tyr 
    1055                 1060                 1065             


Gly Glu  Gly Cys Val Thr Ile  His Glu Ile Glu Asn  Asn Thr Asp 
    1070                 1075                 1080             


Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu Glu Val  Tyr Pro Asn 
    1085                 1090                 1095             


Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala Thr Gln  Glu Glu Tyr 
    1100                 1105                 1110             


Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly Tyr Asp  Gly Ala Tyr 
    1115                 1120                 1125             


Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr Ala Ser  Ala Tyr Glu 
    1130                 1135                 1140             


Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp Asn Pro  Cys Glu Ser 
    1145                 1150                 1155             


Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu Pro Ala  Gly Tyr Val 
    1160                 1165                 1170             


Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr Asp Lys  Val Trp Ile 
    1175                 1180                 1185             


Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile Val Asp  Ser Val Glu 
    1190                 1195                 1200             


Leu Leu  Leu Met Glu Glu 
    1205                 


<210>  6
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic molecule

<400>  6
ctcgaggctg aatctgatct cgaaagggca cagaaagctg taaacgcatt gtttacaagt       60

tctaatcaaa tcggactcaa aaccgatgtt acggactatc acatagatag ggtttctaat      120

cttgtggaat gtctttcaga tgagttttgt ttagatgaga agaaagaact ttcagaaaag      180

gtcaagcacg ccaaaagact gtccgatgaa aggaatctcc ttcaagaccc aaactttcgt      240

ggaatcaata ggcagctcga cagaggttgg agagggagca cagatatcac cattcaagga      300

ggagatgacg ttttcaaaga gaactatgtc accttgttag gcacctttga tgagtgctat      360

ccaacttatc tgtatcagaa gattgatgaa tccaagctga aggcttacac aagatatcag      420

ctcagaggat acatcgagga ctcccaagat ttggagatat acttgattcg ttacaatgca      480

aaacatgaga ccgtgaatgt tcctggtact ggaagtctct ggccactgtc tgctccgtca      540

cctattggga aatgtgccca tcactcccac catttctcat tggacataga cgttggctgc      600

acagatttga atgaagattt gggtgtttgg gtcatcttca agatcaaaac tcaagacgga      660

cacgctcgtt taggaaactt agagtttctt gaagagaagc ccttggttgg ggaggcactt      720

gccagagtaa agagagctga aaagaagtgg agagataaga gggagaaact tgagtgggag      780

actaacattg tgtacaagga agccaaagaa agcgtggatg ctcttttcgt gaactctcag      840

tatgataggt tacaagcaga caccaacata gcaatgatac atgcagctga caaaagagtc      900

cattctattc gtgaggctta cttgccagaa cttagtgtga ttcccggtgt caacgctgcc      960

attttcgagg aattggaagg aagaatcttt acggctttca gcctctatga cgctaggaat     1020

gttatcaaga atggtgattt caacaatggc ctctcatgtt ggaatgtgaa aggtcatgtt     1080

gatgtagagg agcaaaacaa tcaccgtagc gtgctggttg tcccagaatg ggaagccgaa     1140

gtaagccaag aagttagagt ttgccctgga agaggctaca ttctgcgtgt caccgcttac     1200

aaagaaggat atggcgaagg gtgcgtgact attcatgaga ttgagaacaa tactgacgaa     1260

cttaagtttt caaactgcgt cgaggaggaa gtgtatccta acaacacagt gacttgtaat     1320

gactatacag caacgcaaga ggaatacgag gggacataca ccagtcgtaa tcgtggttat     1380

gatggtgctt atgaaagcaa ttcatccgtt ccagctgact atgccagtgc ctacgaagag     1440

aaggcttaca cggatggcag aagagataac ccatgtgagt ccaacagagg ttatggtgat     1500

tacactcctc ttccagctgg ttacgtgact aaagagttag agtactttcc ggagactgat     1560

aaggtttgga ttgaaatcgg agagacagaa gggacattca tagtagattc agttgagctt     1620

cttctcatgg aagaa                                                      1635


<210>  7
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic molecule

<400>  7
ctcgaggctg aatcggatct tgaaagggca cagaaggcag tcaacgctct cttcaccagc       60

tcaaatcaga ttggccttaa gaccgatgtt actgactatc atatcgacag agtttctaac      120

cttgtcgagt gcctctccga cgagttctgt ctcgacgaaa agaaggaact ctccgagaaa      180

gtgaagcacg cgaaacgcct ctcggatgaa cggaacttgc tgcaagatcc gaacttcaga      240

ggcatcaatc gccagttgga tagaggctgg aggggatcaa ccgacataac cattcaaggt      300

ggggatgatg tgttcaagga aaactacgtg acattgctgg gcaccttcga cgagtgctat      360

cccacgtatc tctatcagaa gattgacgag tccaagctca aagcctacac acgctatcag      420

ctcagaggct acattgagga ctctcaagac ctcgaaatct acttgatcag atacaacgcc      480

aagcacgaga cggtgaacgt ccctgggact gggtcactgt ggccactgtc ggcaccctcg      540

ccaatcggaa agtgcgctca ccacagccac cacttctccc ttgacataga tgttgggtgt      600

acggacttga atgaggatct gggtgtgtgg gtgatcttta agatcaagac ccaagatggt      660

catgcgaggc ttggcaacct tgagttcctt gaagagaagc ctttggtcgg agaggcactg      720

gctcgcgtga agagggctga gaagaaatgg agggacaaga gggagaaact ggagtgggag      780

accaacatag tgtacaagga ggccaaggag tcagtggacg cactgtttgt caattcccag      840

tatgataggc tccaagcgga cacgaacatc gccatgatcc atgcagcgga caagagggtt      900

cactccataa gggaggccta tcttccggag ctgtcagtga ttcctggggt caacgcagcc      960

atctttgagg aattggaagg gaggatcttc accgctttct ctctgtacga cgctcggaac     1020

gtcatcaaga atggtgattt caacaatgga ctcagctgct ggaacgtgaa agggcatgtc     1080

gatgttgaag aacagaacaa tcaccgcagc gtgctggtgg ttccggagtg ggaagccgag     1140

gtctcacaag aagtcagagt gtgccctggg aggggttaca tcttgcgggt cacagcctac     1200

aaggaaggtt atggcgaagg ctgtgtcacg atccatgaga tcgaaaacaa cacagacgag     1260

ctgaagtttt ccaactgtgt tgaggaggag gtctatccta acaatactgt tacgtgcaac     1320

gactacacag ccactcaaga ggagtacgag ggcacttaca cctctcgcaa cagaggctac     1380

gacggtgcct acgagtcaaa cagctccgtg ccagcggact acgcctcggc ttacgaagag     1440

aaggcgtaca ccgacggtcg gagggataac ccgtgcgaga gcaatagagg ctatggcgac     1500

tacactcctc tcccagctgg ctacgtgacc aaggagttgg agtactttcc ggagacagac     1560

aaagtctgga ttgagattgg agagacagaa ggcacgttca tcgtggactc tgttgaactc     1620

ttgctgatgg aggag                                                      1635














