                         SEQUENCE LISTING

<110>  Cellagenics B.V.
 
<120>  Novel stringent selectable markers

<130>  P6026026PCT

<150>  US 61/187,022
<151>  2009-06-15

<160>  37    

<170>  PatentIn version 3.3

<210>  1
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic wt Zeo resistance gene

<400>  1
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc     60

gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt    120

gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac    180

aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag    240

gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag    300

ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc    360

gaggagcagg actga                                                     375


<210>  2
<211>  600
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic wt puromycin resistance gene

<400>  2
atgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta     60

cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac    120

cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac    180

atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag    240

agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt    300

tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag    360

cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc    420

agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg    480

gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc    540

gacgtcgagt gcccgaagga ccgcgcgacc tggtgcatga cccgcaagcc cggtgcctga    600


<210>  3
<211>  399
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic wt blasticidin resistance gene

<400>  3
atggccaagc ctttgtctca agaagaatcc accctcattg aaagagcaac ggctacaatc     60

aacagcatcc ccatctctga agactacagc gtcgccagcg cagctctctc tagcgacggc    120

cgcatcttca ctggtgtcaa tgtatatcat tttactgggg gaccttgtgc agaactcgtg    180

gtgctgggca ctgctgctgc tgcggcagct ggcaacctga cttgtatcgt cgcgatcgga    240

aatgagaaca ggggcatctt gagcccctgc ggacggtgcc gacaggtgct tctcgatctg    300

catcctggga tcaaagccat agtgaaggac agtgatggac agccgacggc agttgggatt    360

cgtgaattgc tgccctctgg ttatgtgtgg gagggctaa                           399


<210>  4
<211>  1143
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic wt hygromycin resistance gene

<400>  4
atgaaaaagc ctgaactcac cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac     60

agcgtctccg acctgatgca gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat    120

gtaggagggc gtggatatgt cctgcgggta aatagctgcg ccgatggttt ctacaaagat    180

cgttatgttt atcggcactt tgcatcggcc gcgctcccga ttccggaagt gcttgacatt    240

ggggaattca gcgagagcct gacctattgc atctcccgcc gtgcacaggg tgtcacgttg    300

caagacctgc ctgaaaccga actgcccgct gttctgcagc cggtcgcgga ggccatggat    360

gcgatcgctg cggccgatct tagccagacg agcgggttcg gcccattcgg accgcaagga    420

atcggtcaat acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat    480

cactggcaaa ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag    540

ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc    600

tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg    660

atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct    720

tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg    780

cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac    840

ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga    900

gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc    960

tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc ggaggcaaag   1020

gaattcggga gatgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc   1080

cgcgctatga cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca   1140

taa                                                                 1143


<210>  5
<211>  804
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic neomycin resistance gene

<400>  5
atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag     60

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc    120

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg    180

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc    240

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg    300

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct    360

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg    420

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat    480

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc    540

atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg    600

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc    660

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct    720

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat    780

cgccttcttg acgagttctt ctga                                           804


<210>  6
<211>  564
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic mouse DHFR gene

<400>  6
atggttcgac cattgaactg catcgtcgcc gtgtcccaaa atatggggat tggcaagaac     60

ggagacctac cctggcctcc gctcaggaac gagttcaagt acttccaaag aatgaccaca    120

acctcttcag tggaaggtaa acagaatctg gtgattatgg gtaggaaaac ctggttctcc    180

attcctgaga agaatcgacc tttaaaggac agaattaata tagttctcag tagagaactc    240

aaagaaccac cacgaggagc tcattttctt gccaaaagtt tggatgatgc cttaagactt    300

attgaacaac cggaattggc aagtaaagta gacatggttt ggatagtcgg aggcagttct    360

gtttaccagg aagccatgaa tcaaccaggc cacctcagac tctttgtgac aaggatcatg    420

caggaatttg aaagtgacac gtttttccca gaaattgatt tggggaaata taaacttctc    480

ccagaatacc caggcgtcct ctctgaggtc caggaggaaa aaggcatcaa gtataagttt    540

gaagtctacg agaagaaaga ctaa                                           564


<210>  7
<211>  1121
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic human glutamine synthase gene

<400>  7
atgaccacct cagcaagttc ccacttaaat aaaggcatca agcaggtgta catgtccctg     60

cctcagggtg agaaagtcca ggccatgtat atctggatcg atggtactgg agaaggactg    120

cgctgcaaga cccggaccct ggacagtgag cccaagtgtg tggaagagtt gcctgagtgg    180

aatttcgatg gctccagtac tttacagtct gagggttcca acagtgacat gtatctcgtg    240

cctgctgcca tgtttcggga ccccttccgt aaggacccta acaagctggt gttatgtgaa    300

gttttcaagt acaatcgaag gcctgcagag accaatttga ggcacacctg taaacggata    360

atggacatgg tgagcaacca gcacccctgg tttggcatgg agcaggagta taccctcatg    420

gggacagatg ggcacccctt tggttggcct tccaacggct tcccagggcc ccagggtcca    480

tattactgtg gtgtgggagc agacagagcc tatggcaggg acatcgtgga ggcccattac    540

cgggcctgct tgtatgctgg agtcaagatt gcggggacta atgccgaggt catgcctgcc    600

cagtgggaat ttcagattgg accttgtgaa ggaatcagca tgggagatca tctctgggtg    660

gcccgtttca tcttgcatcg tgtgtgtgaa gactttggag tgatagcaac ctttgatcct    720

aagcccattc ctgggaactg gaatggtgca ggctgccata ccaacttcag caccaaggcc    780

atgcgggagg agaatggtct gaagtacatc gaggaggcca ttgagaaact aagcaagcgg    840

caccagtacc acatccgtgc ctatgatccc aagggaggcc tggacaatgc ccgacgtcta    900

actggattcc atgaaacctc caacatcaac gacttttctg gtggtgtagc caatcgtagc    960

gccagcatac gcattccccg gactgttggc caggagaaga agggttactt tgaagatcgt   1020

cgcccctctg ccaactgcga ccccttttcg gtgacagaag ccctcatccg cacgtgtctt   1080

ctcaatgaaa ccggcgatga gcccttccag tacaaaaatt a                       1121


<210>  8
<211>  1122
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic mouse glutamine synthase gene

<400>  8
atggccacct cagcaagttc ccacttgaac aaaggcatca agcaaatgta catgtccctg     60

ccccagggtg agaaagtcca agccatgtat atctgggttg atggtaccgg agaaggactg    120

cgctgcaaga cccgtaccct ggactgtgag cccaagtgtg tggaagagtt acctgagtgg    180

aactttgatg gctctagtac ctttcagtct gaaggctcca acagcgacat gtacctccat    240

cctgttgcca tgtttcgaga ccccttccgc agagacccca acaagctggt gctatgtgaa    300

gttttcaagt ataaccggaa acctgcagag accaacttga ggcacatctg taaacggata    360

atggacatgg tgagcaacca gcacccctgg tttggaatgg agcaggaata tactcttatg    420

ggaacagacg gccacccatt tggttggcct tccaatggct tccctggacc ccaaggcccg    480

tattactgcg gtgtgggagc agacaaggcc tacggcaggg acatcgtgga ggctcactac    540

cgggcctgct tgtatgctgg agtcaagatt acggggacaa atgcggaggt tatgcctgcc    600

cagtgggaat tccaaatagg accctgtgag gggatccgaa tgggagatca tctttggata    660

gcccgtttta tcttgcatcg ggtgtgcgaa gactttgggg tgatagcaac ctttgacccc    720

aagcccattc cagggaactg gaatgttgca ggctgccata ccaacttcag caccaaggcc    780

atgcgggagg agaatggtct gaagtgcatt gaggaggcca ttgacaaact gagcaagagg    840

caccagtacc acattcgcgc ctacgatccc aaggggggcc tggacaatgc ccgtgctctg    900

actggattcc acgaaacctc caacatcaac gacttttctg ctggtgttgc caaccgcggt    960

gccagtatcc gcattccccg gactgtcggc caggagaaga agggctactt tgaagaccgt   1020

cgccttcgtg ccaattgtga cccctatgcg gtgacagaag ccatcgtccg cacgtgtctc   1080

ctcaacgaaa caggcgacga acccttccaa tacaagaact aa                      1122


<210>  9
<211>  1221
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic cystathione gamma-lyase gene

<400>  9
atgggccagg aaaaagacgc ctcctcacaa ggtttcctgc cacacttcca acatttcgcc     60

acgcaggcga tccatgtggg ccaggacccg gagcaatgga cctccagggc tgtagtgccc    120

cccatctcac tgtccaccac gttcaagcaa ggggcgcctg gccagcactc gggttttgaa    180

tatagccgtt ctggaaatcc cactaggaat tgccttgaaa aagcagtggc agcactggat    240

ggggctaagt actgtttggc ctttgcttca ggtttagcag ccactgtaac tattacccat    300

cttttaaaag caggagacca aattatttgt atggatgatg tgtatggagg tacaaacagg    360

tacttcaggc aagtggcatc tgaatttgga ttaaagattt cttttgttga ttgttccaaa    420

atcaaattac tagaggcagc aattacacca gaaaccaagc tcgtttggat cgaaaccccc    480

acaaacccca cccagaaggt gattgacatt gaaggctgtg cacatattgt ccataagcat    540

ggagacatta ttttggtcgt ggataacact tttatgtcac catatttcca gcgccctttg    600

gctctgggag ctgatatttc tatgtattct gcaacaaaat acatgaatgg ccacagtgat    660

gttgtaatgg gcctggtgtc tgttaattgt gaaagccttc ataatagact tcgtttcttg    720

caaaactctc ttggagcagt tccatctcct attgattgtt acctctgcaa tcgaggtctg    780

aagactctac atgtccgaat ggaaaagcat ttcaaaaacg gaatggcagt tgcccagttc    840

ctggaatcta atccttgggt agaaaaggtt atttatcctg ggctgccctc tcatccacag    900

catgagttgg tgaagcgtca gtgcacaggt tgcacaggga tggtcacctt ttatattaag    960

ggcactcttc agcacgctga gattttcctc aagaacctaa agctatttac tctggccgag   1020

agcttgggag gattcgagag ccttgctgag cttccggcaa tcatgactca tgcatcagtt   1080

cttaagaatg acagagatgt ccttggaatt agtgacacac tgattcgact ttctgtgggc   1140

ttagaggatg aggaagacct actggaagac ctagatcagg ctttgaaggc agcacaccct   1200

ccaagtggga ttcacagcta g                                             1221


<210>  10
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic wild type zeocin resistance protein

<400>  10

Met Ala Lys Leu Thr Ser Ala Val Pro Val Leu Thr Ala Arg Asp Val 
1               5                   10                  15      


Ala Gly Ala Val Glu Phe Trp Thr Asp Arg Leu Gly Phe Ser Arg Asp 
            20                  25                  30          


Phe Val Glu Asp Asp Phe Ala Gly Val Val Arg Asp Asp Val Thr Leu 
        35                  40                  45              


Phe Ile Ser Ala Val Gln Asp Gln Val Val Pro Asp Asn Thr Leu Ala 
    50                  55                  60                  


Trp Val Trp Val Arg Gly Leu Asp Glu Leu Tyr Ala Glu Trp Ser Glu 
65                  70                  75                  80  


Val Val Ser Thr Asn Phe Arg Asp Ala Ser Gly Pro Ala Met Thr Glu 
                85                  90                  95      


Ile Gly Glu Gln Pro Trp Gly Arg Glu Phe Ala Leu Arg Asp Pro Ala 
            100                 105                 110         


Gly Asn Cys Val His Phe Val Ala Glu Glu Gln Asp 
        115                 120                 


<210>  11
<211>  3500
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human beta-actin promoter

<400>  11
gccccagtga cagctccgaa agctccctta cagggcaaag ttcccaagca cagaagagaa     60

cctgttcact tctcccctgc tcggcccgcc ccctggccag gcacctctac ttcctctttt    120

cctgctccgc tgcttgcttt ctctcttcag ctcctccctg cccctcaccc caggctgctc    180

ggccacctcc aacctgccac ctgaggacac ccaggcagtc actcattcaa cagcgaggag    240

ccctggggtg ggtgtagtgg gaaggagtgg gggtgacgga gaccctggga gggctcgcag    300

cctggtggct gaggcccagt tctaaatgcc agctgcaagc cttggtctga ggtagggagg    360

aaggcgtggc tgcagaggct aaaacgcttc cccaaagagg ggctttctgg gatgggactt    420

gaagggtgca taggagagca ctaggaagtg gccgctgcag acagagggaa ccacaagcca    480

ggaggacagg ccaggaatgc tgcagcccgg ggcggggtgg ggctggagct cctgtctctt    540

ggccagctga atggaggccc agtggcaaca caggtcctgc ctggggatca ggtctgctct    600

gcaccccacc ttgctgcctg gagccgccca cctgacaacc tctcatccct gctctgcaga    660

tccggtccca tccccactgc ccaccccacc cccccagcac tccacccagt tcaacgttcc    720

acgaaccccc agaaccagcc ctcatcaaca ggcagcaaga agggcccccc gcccatcgcc    780

ccacaacgcc agccgggtga acgttggcag gtcctgaggc agctggcaag acgcctgcag    840

ctgaaagata caaggccagg gacaggacag tcccatcccc aggaggcagg gagtatacag    900

gctggggaag tttgcccttg cgtggggtgg tgatggagga ggctcagcaa gtcttctgga    960

ctgtgaacct gtgtctgcca ctgtgtgctg ggtggtggtc atctttccca ccaggctgtg   1020

gcctctgcaa ccttcaaggg aggagcaggt cccattggct gagcacagcc ttgtaccgtg   1080

aactggaaca agcagcctcc ttcctggcca caggttccat gtccttatat ggactcatct   1140

ttgcctattg cgacacacac tcagtgaaca cctactacgc gctgcaaaga gccccgcagg   1200

cctgaggtgc ccccacctca ccactcttcc tatttttgtg taaaaatcca gcttcttgtc   1260

accacctcca aggaggggga ggaggaggaa ggcaggttcc tctaggctga gccgaatgcc   1320

cctctgtggt cccacgccac tgatcgctgc atgcccacca cctgggtaca cacagtctgt   1380

gattcccgga gcagaacgga ccctgcccac ccggtcttgt gtgctactca gtggacagac   1440

ccaaggcaag aaagggtgac aaggacaggg tcttcccagg ctggctttga gttcctagca   1500

ccgccccgcc cccaatcctc tgtggcacat ggagtcttgg tccccagagt cccccagcgg   1560

cctccagatg gtctgggagg gcagttcagc tgtggctgcg catagcagac atacaacgga   1620

cggtgggccc agacccaggc tgtgtagacc cagccccccc gccccgcagt gcctaggtca   1680

cccactaacg ccccaggcct tgtcttggct gggcgtgact gttaccctca aaagcaggca   1740

gctccagggt aaaaggtgcc ctgccctgta gagcccacct tccttcccag ggctgcggct   1800

gggtaggttt gtagccttca tcacgggcca cctccagcca ctggaccgct ggcccctgcc   1860

ctgtcctggg gagtgtggtc ctgcgacttc taagtggccg caagccacct gactccccca   1920

acaccacact ctacctctca agcccaggtc tctccctagt gacccaccca gcacatttag   1980

ctagctgagc cccacagcca gaggtcctca ggccctgctt tcagggcagt tgctctgaag   2040

tcggcaaggg ggagtgactg cctggccact ccatgccctc caagagctcc ttctgcagga   2100

gcgtacagaa cccagggccc tggcacccgt gcagaccctg gcccacccca cctgggcgct   2160

cagtgcccaa gagatgtcca cacctaggat gtcccgcggt gggtgggggg cccgagagac   2220

gggcaggccg ggggcaggcc tggccatgcg gggccgaacc gggcactgcc cagcgtgggg   2280

cgcgggggcc acggcgcgcg cccccagccc ccgggcccag caccccaagg cggccaacgc   2340

caaaactctc cctcctcctc ttcctcaatc tcgctctcgc tctttttttt tttcgcaaaa   2400

ggaggggaga gggggtaaaa aaatgctgca ctgtgcggcg aagccggtga gtgagcggcg   2460

cggggccaat cagcgtgcgc cgttccgaaa gttgcctttt atggctcgag cggccgcggc   2520

ggcgccctat aaaacccagc ggcgcgacgc gccaccaccg ccgagaccgc gtccgccccg   2580

cgagcacaga gcctcgcctt tgccgatccg ccgcccgtcc acacccgccg ccaggtaagc   2640

ccggccagcc gaccggggca ggcggctcac ggcccggccg caggcggccg cggccccttc   2700

gcccgtgcag agccgccgtc tgggccgcag cggggggcgc atgggggggg aaccggaccg   2760

ccgtgggggg cgcgggagaa gcccctgggc ctccggagat gggggacacc ccacgccagt   2820

tcggaggcgc gaggccgcgc tcgggaggcg cgctccgggg gtgccgctct cggggcgggg   2880

gcaaccggcg gggtctttgt ctgagccggg ctcttgccaa tggggatcgc agggtgggcg   2940

cggcggagcc cccgccaggc ccggtggggg ctggggcgcc attgcgcgtg cgcgctggtc   3000

ctttgggcgc taactgcgtg cgcgctggga attggcgcta attgcgcgtg cgcgctggga   3060

ctcaaggcgc taactgcgcg tgcgttctgg ggcccggggt gccgcggcct gggctggggc   3120

gaaggcgggc tcggccggaa ggggtggggt cgccgcggct cccgggcgct tgcgcgcact   3180

tcctgcccga gccgctggcc gcccgagggt gtggccgctg cgtgcgcgcg cgccgacccg   3240

gcgctgtttg aaccgggcgg aggcggggct ggcgcccggt tgggaggggg ttggggcctg   3300

gcttcctgcc gcgcgccgcg gggacgcctc cgaccagtgt ttgcctttta tggtaataac   3360

gcggccggcc cggcttcctt tgtccccaat ctgggcgcgc gccggcgccc cctggcggcc   3420

taaggactcg gcgcgccgga agtggccagg gcgggggcga cctcggctca cagcgcgccc   3480

ggctattctc gcagctcacc                                               3500


<210>  12
<211>  1639
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic luciferase gene

<400>  12
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga     60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatg    120

cttttacaga tgcacatatc gaggtggaca tcacttacgc tgagtacttc gaaatgtccg    180

ttcggttggc agaagctatg aaacgatatg ggctgaatac aaatcacaga atcgtcgtat    240

gcagtgaaac tctcttcaat tctttatgcc ggtgttgggc gcgttattta tcggagttgc    300

agttgcgccc gcgaacgaca tttataatga acgtgaattg ctcaacagta tgggcatttc    360

gcagcctacc gtgtgttcgt ttccaaaaag gggttgcaaa aaattttgaa cgtgcaaaaa    420

aagctcccaa tcatccaaaa aattattatc atggattcta aaacggatta ccagggattt    480

cagtcgatgt acacgttcgt acatctcatc tacctcccgg ttttaatgaa tacgattttg    540

tgccagagtc cttcgatagg gacaagacaa ttgcactgat catgaactcc tctggatcta    600

ctggtctgcc taaaggtgtc gctctgctca tagaactgcc tgcgtgagat tctcgcatgc    660

cagagatcct atttttggca atcaaatcat tccggatact gcgattttaa gtgttgttcc    720

attccatcac ggttttggaa tgtttactac actcgatatt tgatatgtgg atttcgagtc    780

gtcttaatgt atagatttga agagagctgt ttctgaggag ccttcaggat tacaagattc    840

aaagtgcgct gctggtgcca accctattct ccttcttcgc caaagcactc tgattgacaa    900

atacgattta tctaatttac acgaaattgc ttctggtggc gctcccctct ctaaggaagt    960

cggggaagcg gttgccaaga ggttccatct gccaggtatc aggcaaggta tgggctcact   1020

gagactacat cagctattct gattacaccc gagggggatg ataaaccggg cgcggtcggt   1080

aaagttgttc cattttttga agcgaaggtt gtggatctgg atacgggaaa acgctggcgt   1140

taatcaaaga ggcgaactgt gtgtgagagg tcctatgatt atgtccggtt atgtaaacaa   1200

tccggaagcg accaacgcct tgattgacaa ggatggatgg ctacattctg gagacatagc   1260

ttctgggacg aagacgaaca cttcttcatc gttgaccgcc tgaagtctct gattaagtac   1320

aaaggctatc aggtggctcc cgctgaattg gaatccatct tgctccaaca ccccaacatc   1380

ttcgacgcag tgtcgcaggt cttcccgacg atgacgccgg tgaacttccc gccgccgttg   1440

ttgttttgga gcacggaaag acgatgacgg aaaaagagat cgtggattac gtcgccagtc   1500

aagtaacaac cgcgaaaagt tgcgcggagg agttgtgttt gtggacgaag taccgaaagg   1560

tcttaccgga aaactcgacg caagaaaaat cagagagatc ctcataaagg ccaagaaggg   1620

cggaaagatc gccgtgtaa                                                1639


<210>  13
<211>  270
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic pp90

<400>  13
gaaattgctt ctggtggcgc tcccctctct aaggaagtcg gggaagcggt tgccaagagg     60

ttccatctgc caggtatcag gcaaggatat gggctcactg agactacatc agctattctg    120

attacacccg agggggatga taaaccgggc gcggtcggta aagttgttcc attttttgaa    180

gcgaaggttg ggatctggat acgggaaaac gctgggcgtt aatcaaagag gcgaactgtg    240

tgtgagaggt cctatgatta tgtccggtta                                     270


<210>  14
<211>  219
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic pp75

<400>  14
gccaagaggt tccatctgcc aggtatcagg caaggatatg ggctcactga gactacatca     60

gctattctga ttacacccga gggggatgat aaaccgggcg cggtcggtaa agttgttcca    120

ttttttgaag cgaaggttgg gatctggata cgggaaaacg ctgggcgtta atcaaagagg    180

cgaactgtgt gtgagaggtc ctatgattat gtccggtta                           219


<210>  15
<211>  159
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic pp54

<400>  15
gctattctga ttacacccga gggggatgat aaaccgggcg cggtcggtaa agttgttcca     60

ttttttgaag cgaaggttgg gatctggata cgggaaaacg ctgggcgtta atcaaagagg    120

cgaactgtgt gtgagaggtc ctatgattat gtccggtta                           159


<210>  16
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic pp23

<400>  16
gggaaaacgc tgggcgttaa tcaaagaggc gaactgtgtg tgagaggtcc tatgattatg     60

tccggtta                                                              68


<210>  17
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic pp9

<400>  17
gtgagaggtc ctatgattat gtccggtta                                       29


<210>  18
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  pp90-forward primer

<400>  18
aggcgctagc atggaaattg cttctggtgg cgctc                                35


<210>  19
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  pp75-forward primer

<400>  19
aggcgctagc atggccaaga ggttccatct g                                    31


<210>  20
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  pp54-forward primer

<400>  20
aggcgctagc atggctattc tgattacacc cgag                                 34


<210>  21
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  pp23-forward primer

<400>  21
aggcgctagc atggggaaaa cgctgggcgt taatc                                35


<210>  22
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  pp9-forward primer

<400>  22
aggcgctagc atgtgagagg tcctatgatt atgtc                                35


<210>  23
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  luc stop-reverse primer

<400>  23
aggcactagt ttaaccggac ataatcatag gac                                  33


<210>  24
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  alpha97 primer

<400>  24
attaggatcc accatggcca agttgaccag tgccg                                35


<210>  25
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  alpha100 primer

<400>  25
accggaattc tcagtcctgc tcctcggcca cg                                   32


<210>  26
<211>  550
<212>  PRT
<213>  Artificial

<220>
<223>  luciferase amino acid sequence

<400>  26

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  27
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  PPx amino acid sequence

<400>  27

Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu 
1               5                   10                  15      


Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp 
            20                  25                  30          


Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro 
        35                  40                  45              


Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro 
    50                  55                  60                  


Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu 
65                  70                  75                  80  


Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val 
                85                  90                  95      


Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu 
            100                 105                 110         


Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met 
        115                 120                 125             


Ser 
    


<210>  28
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic 19 nt spacer between PPx and ATG of selectable marker

<400>  28
actagcatta ggatccacc                                                  19


<210>  29
<211>  7
<212>  RNA
<213>  Artificial

<220>
<223>  Kozak sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or u

<400>  29
annaugn                                                                7


<210>  30
<211>  7
<212>  RNA
<213>  Artificial

<220>
<223>  Kozak sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is a, c, g, or u

<400>  30
gnnaugg                                                                7


<210>  31
<211>  10
<212>  RNA
<213>  Artificial

<220>
<223>  Kozak sequence


<220>
<221>  misc_feature
<223>  r = a or g (purine)

<400>  31
gccrccaugg                                                            10


<210>  32
<211>  377
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic spacer sequence

<400>  32
taaggatccc tcatcatcaa ctcctctcga tctactcgtc tccctcaagg tatcgctctc     60

cctcaaagaa ctccctccgt cagatcctcg catcccagag atcctatcta gatcctatat    120

catccaaaaa atcatcatca tcgatcctca aatcgatcac cagggatctc agtcgatcta    180

catcttcgtc acatctcatc tacctcccgg ttttcatcaa tatcatcttc taccagagtc    240

cttcgaaagg gacaagacaa tcccactcat catcaactcc tctcgatcta ctcgtctccc    300

tcaaggtatc gctctccctc aaagaactcc ctccgtcaga tcctcgcatc ccagagatcc    360

tatctagatc caccatg                                                   377


<210>  33
<211>  411
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic DNA encoding the pp8Zeo-EPP5 selection marker

<400>  33
atgggtccta tgattatgtc cggttaagga tccaccatgg ccaagttgac cagtgccgtt     60

ccggtgctca ccgcgcgcga cgtcgcagga gcggtcgggt tctggaccga ccggctcggg    120

ttctcccggg acttcgtgga ggacgacttc gccggtgtgg tccgggacga cgtgaccctg    180

ttcatcagcg cggtccagga ccaggtggtg ccggacaaca ccctggcctg ggtgtgtgtg    240

cgcggcctgg acgagctgta caccgagtgg tcggaggtcg tgtccacgaa cttccgggac    300

gcctccgggc cggccatgac cgagatcggc gagcagccgt gggggcggga gttcgccctg    360

cgcgacccgg ccggcaactg cgtgcacttc gtggccgagg agcaggactg a             411


<210>  34
<211>  1312
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic DNA encoding the pp23CLase selection marker

<400>  34
atggggaaaa cgctgggcgt taatcaaaga ggcgaactgt gtgtgagagg tcctatgatt     60

atgtccggtt aaactagcat taggatccac catgggccag gaaaaagacg cctcctcaca    120

aggtttcctg ccacacttcc aacatttcgc cacgcaggcg atccatgtgg gccaggaccc    180

ggagcaatgg acctccaggg ctgtagtgcc ccccatctca ctgtccacca cgttcaagca    240

aggggcgcct ggccagcact cgggttttga atatagccgt tctggaaatc ccactaggaa    300

ttgccttgaa aaagcagtgg cagcactgga tggggctaag tactgtttgg cctttgcttc    360

aggtttagca gccactgtaa ctattaccca tcttttaaaa gcaggagacc aaattatttg    420

tatggatgat gtgtatggag gtacaaacag gtacttcagg caagtggcat ctgaatttgg    480

attaaagatt tcttttgttg attgttccaa aatcaaatta ctagaggcag caattacacc    540

agaaaccaag ctcgtttgga tcgaaacccc cacaaacccc acccagaagg tgattgacat    600

tgaaggctgt gcacatattg tccataagca tggagacatt attttggtcg tggataacac    660

ttttatgtca ccatatttcc agcgcccttt ggctctggga gctgatattt ctatgtattc    720

tgcaacaaaa tacatgaatg gccacagtga tgttgtaatg ggcctggtgt ctgttaattg    780

tgaaagcctt cataatagac ttcgtttctt gcaaaactct cttggagcag ttccatctcc    840

tattgattgt tacctctgca atcgaggtct gaagactcta catgtccgaa tggaaaagca    900

tttcaaaaac ggaatggcag ttgcccagtt cctggaatct aatccttggg tagaaaaggt    960

tatttatcct gggctgccct ctcatccaca gcatgagttg gtgaagcgtc agtgcacagg   1020

ttgcacaggg atggtcacct tttatattaa gggcactctt cagcacgctg agattttcct   1080

caagaaccta aagctattta ctctggccga gagcttggga ggattcgaga gccttgctga   1140

gcttccggca atcatgactc atgcatcagt tcttaagaat gacagagatg tccttggaat   1200

tagtgacaca ctgattcgac tttctgtggg cttagaggat gaggaagacc tactggaaga   1260

cctagatcag gctttgaagg cagcacaccc tccaagtggg attcacagct ag           1312


<210>  35
<211>  6969
<212>  DNA
<213>  Homo sapiens

<400>  35
ctatgtcatt tttgctaaca tgtaatgggc ttactattgt tattttaatt aaattgataa     60

atatatattt aaaatgttct tagtttaaat ttctaatata gtaaatattg atagatacaa    120

cctacataaa caaaagctat atggagtcct caataatttt taagaatgta aagggattct    180

gaggccaaaa tgtttgagaa ttgctgggct aggattgttc aagcctctct ggggcatatg    240

ctaattatct taaagccacc caatcatcac ccaccttccc accaatgtct tcgtactcac    300

ttcttgtgag ccaatcctca cagtcaggag gcagtagtgt taggatggtt gaaagtaaaa    360

gcacaaagag attgagttca aattctttct tggctacctg tgaagtttgt aactttgact    420

aatttactgg gcccttcaaa agtctcagtt ttctcatcta taaaaggggt ataatggtag    480

tacctacctt atacgtttgt gagaattaag aaagaaggca cataatttat gttagctata    540

atagatgaaa ttctttagag ttttatttgt ggttatctaa tcataaggat tggaaagaag    600

taaagtccat gccaacttgt tttacttctt tgaaaaagag aaacaagagg tatagtaacg    660

tttaatgttt ggtttaacat gtacagtgga tgagagggca ttctatattg atctcctcaa    720

tctggccaga aaagtgttgt gatttctaac agtttatttt cacattttgt ttccctaagt    780

tcaatgagcc ctccacttct aatgaggtgg ctttagggta gagaaatcaa aaggcagttg    840

gctttgttgt gacgggcaga tctggatgga gcattataag ggtgaggctg ctgagtttcc    900

catcttgctt atacatatga tgctttgaaa cctacgctga cctgttttaa ctctggccta    960

aagacaggcc aggtgaacag aaatagagcc agcgtctcca ctggcaacac agccatcctg   1020

aagaggaatg tctgtgtgtg catctgccac cagaagtggg atgctagaga ggcattgatc   1080

tcttttttga tattgagttt tatccaagta ctcattaagt agatcccttt tattttcaaa   1140

atatctgggg ttaatgtgct taatttggtt agacctagtg agtgagctat ggagaactgg   1200

aatcatttta tatcagttcc tcatctttgc tcagattcat tctgtactgc ctgtctcttc   1260

tgcttcttag acaaagattg aacttgcagg ccaggtgcag tggctcatgc ctgtaattcc   1320

aacactttgg gaggccgagg cgggcagatc acttgaggtc gggaattcga aaccagcctg   1380

accaacatgg agaaaccccg cctctactaa aaatacaaag ttagctgggt gtggtggtgc   1440

atgcctgtaa tcccagctac tcaggaggct gaggcaggag aattgcttca acccaggaga   1500

cggagattgt ggtgagccga ggtgacgcca ttgcactcca gcctgggcaa caagagtgaa   1560

actccatctc aaaataaata aataaaaaga ttgaacttgc tacatgcttc tatctctatc   1620

tgccttctgt gctgccagct cctgcttcta gcaagaagca agagaactta tgttttttca   1680

acccctagtt ctctcctggt aaaactgtga agaatctatt tgcatatcta gccattctac   1740

atgcataaaa atgctatatc gacacaaaga aaagacttgt tcataggctc atagttctga   1800

tacaaggctt accagctgaa ttgcccacag tcaggcccta cagagaactc tgctagtttg   1860

atactcctat taatatacag ctaataggtg gtcctgtatc ctacagctgt ggccaaggtc   1920

ccacacacaa tcaattttcc attccgttag actgggaggg agattgttag ctttctatga   1980

acataagaag atcccctgat ggagccatct acataggata ggtttttgta taggtttaat   2040

gacccttcag agttggtaaa tggtccacaa tttctctaac cttcacttcc tggacccaaa   2100

gagagattgg caccaacttt actgtgtcat taatttcagg agtcattcac tgaccttctc   2160

cagcagtggc agcaactccc caagtcaatc aggcaataaa accagctgta ccaaaaatgt   2220

aacaacagtt caagtttact ttatccaggg gcctcaagta ttcaagattg acgtccctac   2280

ctccccatct ccaaggatgc ccccccctcc ccgccatgat gatacccaag agtgagtcag   2340

tgtagccagg taccattgcc cacaggaggc tcagctttgt ccctttcaaa tgatcctccc   2400

caagggcttc tgtttctctt acttctagcc atttggtctt agccattgtg tttcctgtga   2460

tccatatgcc aagcccccac atcttacata ggccattgga aatttgggtg ctctgggaaa   2520

cctcattaat caaaccatgt cctgcaaggc tgactgccaa ccagcccaaa gactgacctg   2580

gtgtcacaga gatgtcctga aggccttctc ctcctggtga agcccatcat caagaagatg   2640

ttggacttgc agatccagac aagagaatat gaggatgttc ttaccacatc aggcagtaat   2700

acaatggcct cctaactggt gtccttgtgc ccgtgctttt cctcttctcc attccccata   2760

cagcagtcag gaaatctgat tgtgttcttc ctttgtttaa aaccctttcc tgtgtcccac   2820

atgatggcct gcatgatcct tcatgccctt gaccttgcca acctctcagg tctcatctca   2880

tgccaccttc ttcctccctg ctgtgctcag gccacatggc cttcctctag ctcctcaagt   2940

gcctagaggc ccttccagag gctggtccct ttgactcttc aactcattaa tttccactca   3000

tccttcagag ctcagctcaa atgtcacttc ctcgaggcga ctgtccttga gtccccactc   3060

gctcatcata cttttgctag ctctgcgtcc cgttccatca taggttgtaa ttacaagtct   3120

gagtaatgtg tgcctccttt agtggcttgt aaggttcatg aaggcaggat ctatatctat   3180

caaagttccc cctgaattct gagtacctac acagtaggag tctgataaat atttattgga   3240

caaataaatc aacaaaaata aatatggaaa agttgctatt gtgggcttca ccagttggtg   3300

agtacagatg tagtcctata acttcataca ctttcaattg ctctatcaca tttgtgatag   3360

ctatgaagtt tttccttcta tgcaacatgc tgctattaga cagctacagg aatgagtgaa   3420

tagcttctcc tctagtttct tgtcctcaat ctctctcttt cctcccctct ggcccaccct   3480

aaatacttat acaggcgagt gtggacacac acacacacac acatcctgtg aagaggaatg   3540

agagcacaaa aagttatata caattcattg taatatgaat caggaaaaag cttcctgact   3600

tcagcctaaa gattccctgg gctgagggga aagggaatgt ccagatggca aatggagtga   3660

ggagagaact tatcctggtg ggtcactgaa aagagtgcta agcctgctcc agtggggaag   3720

aggaagatga cagaaatgtc aggtaagttt gtgggaactg aaaggggagg caatctagaa   3780

gtgttctcag gcaaaggccc aaggagaccc aagatctcag agactaaggt gctatgtggc   3840

agatatgagt ctgggacagc ttacagagtc ccatacgtca cagtgtggcc tggaagcaga   3900

tggatggttc tggggcctga gagtgccgca ggagtccatg ggtcttgggt cacagcctgc   3960

agtttccatg actcagcctg gcagtggaat gacttcctgg gcaccccaaa ggctttatag   4020

aagttgaaag gatagttgtc aaacgtgcag gagcctttta aatgggatca tagggacaag   4080

gtagcaatca tctgcatgtc aggaaacgaa cactaaacag gatgatggat ggcccagtga   4140

aggcccaggt gatagcagtc tagaaccagg taccccatct ccccacatgt tgacatgcca   4200

caagcacccc agaaattagt tatttccctg cagttacata ttgactaatt ttaaattgtt   4260

actgcttaca ggatggaggc tctaaataga aaaaaagtta gagagaaaca taaatttgtt   4320

atgtttttat acagctgggt ttgtgggctg caaattgaaa ccattataca attctctttt   4380

aaaatgcaaa tatccctcat acgcatatca tgtggacaaa gtgtttgttt tattaatagc   4440

atcccctaac ctagtttcac tattaaaagg taggtctgag tgggatgtgg gtccctagtg   4500

acctagtgtg agaatagagg gtgttttgtt ttgttttgtt tttgagactg agtctcgctc   4560

tgttgcccag gctggagtgc agtggcatga tctcggctca ctgcaacctc tgcctcctgg   4620

gttcaagtga ttctcatgcc tcagcctctt gagtagctgg gattagatgt gcccaacacc   4680

acgcctgact aatttttgta tttttagtag ggatggggtt tcaccatgtt ggccaggctg   4740

gtctcaaact cctgacctca agtaatccac ccactttggt ctcccaaagt gctgggatta   4800

caggcgtgag ccaccacgtc cggccttaga gggcatttta agggaagaag agaggagttg   4860

ggaaaggatc ttctttctaa tgggaagaga aagaagagac aatagaaaaa ggaagaagga   4920

aaagggccca atgaatgtcc aatattcctt ttgttttcat tgtgattctc atacagaatt   4980

cataaatact tcaacctaaa ccattgaaat tggaatttaa tctgaggtat gaaaaaaatg   5040

ctaggtttaa aatcacaacc caggttgaat ttcttacttt gcccattaat agatgtgtga   5100

ccttgagcat tctcttaact tctctgagcc tcagttactt cagttgtaaa aagggtctaa   5160

taaaacacat cccactgaat tactgagagg attgatccaa ttacatgaaa gagctctgaa   5220

acaataaaaa gttgcaccat ctggggtatc agtttgcggt cgaggagaca atggggagaa   5280

ataatgtaag tgttgagcac atctgcggtc tttaaacaga gagctcaaca caaggacatg   5340

ggcatattgg aaaaaactat ttcagaagag gggaaaaggg agaaaggggg atatgtgggt   5400

attagaggca aacccagata tcctgccttg aggtcaaata attataacat taaatcctgt   5460

ttactgatgc ttagctgtca ggctcttgct catttacctt ggagatccat ttagaattag   5520

tgtaaggtgt aattgacctg tacttagagt tccagaatag gacaatcact tccaaatgcc   5580

ctcagtataa gaaattaaca gtacttgggg ctttagaaat caatgttcaa cctttcaact   5640

actagaaagc ctttttagtt attgtgctta ctatgaaagc ccttggctgt cagttcaaca   5700

agtcgttctt gctttgtgac atctctggaa gtttaatagt tctgtgagaa agtccttgtc   5760

agtgttctga aaactgggaa ttaggaagtc gacttccaat caagcttcag atgacatgcg   5820

acatgcgtta agtttagaaa taacgttagt gtttctaatt tagcatcgtg ttggagtcct   5880

aattatgaaa tgacattaag aaaattccat tcctcagaat tcttgtgcag tagcattggg   5940

tagaaacacc attgtgttct gtgacctggg gtagggatga tatctcaaaa acgcatgctc   6000

aggttgccca tggtgatagc taaactgtct tctcaggaga ggagcaggct ttattaactg   6060

gaactcacca gatttcacag aacattttga agggcttagg attgtgagtt tggaggtaga   6120

tgccaagcag aggtaaacat tttgtataac agaagaaaca tatttgatat gggagagaga   6180

cagaaatctt gtggaaaact ccagagccat caaagctggg acagtgttaa agacgagcac   6240

cctggaagtg aggagccaag tgtgggtttt gaggaacaga tatattaagg gggattctca   6300

caaatgtttt attttgacaa atatcaataa tttagaaaag ttgcaagaat agtatagcaa   6360

ttattcatat accccttcca tatagtacac agaaaaagag ggtatatatt ttaataaata   6420

tttgtgtata cacattttgt gtatagatag gcagataaat agataaagag acaaatgtgc   6480

acctgtgtat aattttctga actgtttgag aattggttgt aagcatcacg acacttcacc   6540

accaaatact tcagcatgtg tctcctaaga acaaggctgt tctctacatg accacaacat   6600

agttatttca cccagaaact taaacttgat acaatacaat atctaatatt cagtccatat   6660

tcaaatttct cctatcatcc aaataatatc attactaatc tccaatataa agagatttaa   6720

aacatgtttt ccatgttcaa cataaatgtc ttctccattt ttcttacaaa atcatcaaaa   6780

acaactacgt ttcccattta tacttttaca ccagtagttt ctttggagga acttgcactt   6840

gtcccacatc cagattggca ggggataaaa tagaaataat aagagctggc agaagagagg   6900

ctggttgatg ctgattacat tcaaaataac tatttggagg aaaaagcact gattctgttc   6960

ctggggtgt                                                           6969


<210>  36
<211>  3498
<212>  DNA
<213>  Homo sapiens

<400>  36
gcccacccta aatacttata caggcgagtg tggacacaca cacacacaca catcctgtga     60

agaggaatga gagcacaaaa agttatatac aattcattgt aatatgaatc aggaaaaagc    120

ttcctgactt cagcctaaag attccctggg ctgaggggaa agggaatgtc cagatggcaa    180

atggagtgag gagagaactt atcctggtgg gtcactgaaa agagtgctaa gcctgctcca    240

gtggggaaga ggaagatgac agaaatgtca ggtaagtttg tgggaactga aaggggaggc    300

aatctagaag tgttctcagg caaaggccca aggagaccca agatctcaga gactaaggtg    360

ctatgtggca gatatgagtc tgggacagct tacagagtcc catacgtcac agtgtggcct    420

ggaagcagat ggatggttct ggggcctgag agtgccgcag gagtccatgg gtcttgggtc    480

acagcctgca gtttccatga ctcagcctgg cagtggaatg acttcctggg caccccaaag    540

gctttataga agttgaaagg atagttgtca aacgtgcagg agccttttaa atgggatcat    600

agggacaagg tagcaatcat ctgcatgtca ggaaacgaac actaaacagg atgatggatg    660

gcccagtgaa ggcccaggtg atagcagtct agaaccaggt accccatctc cccacatgtt    720

gacatgccac aagcacccca gaaattagtt atttccctgc agttacatat tgactaattt    780

taaattgtta ctgcttacag gatggaggct ctaaatagaa aaaaagttag agagaaacat    840

aaatttgtta tgtttttata cagctgggtt tgtgggctgc aaattgaaac cattatacaa    900

ttctctttta aaatgcaaat atccctcata cgcatatcat gtggacaaag tgtttgtttt    960

attaatagca tcccctaacc tagtttcact attaaaaggt aggtctgagt gggatgtggg   1020

tccctagtga cctagtgtga gaatagaggg tgttttgttt tgttttgttt ttgagactga   1080

gtctcgctct gttgcccagg ctggagtgca gtggcatgat ctcggctcac tgcaacctct   1140

gcctcctggg ttcaagtgat tctcatgcct cagcctcttg agtagctggg attagatgtg   1200

cccaacacca cgcctgacta atttttgtat ttttagtagg gatggggttt caccatgttg   1260

gccaggctgg tctcaaactc ctgacctcaa gtaatccacc cactttggtc tcccaaagtg   1320

ctgggattac aggcgtgagc caccacgtcc ggccttagag ggcattttaa gggaagaaga   1380

gaggagttgg gaaaggatct tctttctaat gggaagagaa agaagagaca atagaaaaag   1440

gaagaaggaa aagggcccaa tgaatgtcca atattccttt tgttttcatt gtgattctca   1500

tacagaattc ataaatactt caacctaaac cattgaaatt ggaatttaat ctgaggtatg   1560

aaaaaaatgc taggtttaaa atcacaaccc aggttgaatt tcttactttg cccattaata   1620

gatgtgtgac cttgagcatt ctcttaactt ctctgagcct cagttacttc agttgtaaaa   1680

agggtctaat aaaacacatc ccactgaatt actgagagga ttgatccaat tacatgaaag   1740

agctctgaaa caataaaaag ttgcaccatc tggggtatca gtttgcggtc gaggagacaa   1800

tggggagaaa taatgtaagt gttgagcaca tctgcggtct ttaaacagag agctcaacac   1860

aaggacatgg gcatattgga aaaaactatt tcagaagagg ggaaaaggga gaaaggggga   1920

tatgtgggta ttagaggcaa acccagatat cctgccttga ggtcaaataa ttataacatt   1980

aaatcctgtt tactgatgct tagctgtcag gctcttgctc atttaccttg gagatccatt   2040

tagaattagt gtaaggtgta attgacctgt acttagagtt ccagaatagg acaatcactt   2100

ccaaatgccc tcagtataag aaattaacag tacttggggc tttagaaatc aatgttcaac   2160

ctttcaacta ctagaaagcc tttttagtta ttgtgcttac tatgaaagcc cttggctgtc   2220

agttcaacaa gtcgttcttg ctttgtgaca tctctggaag tttaatagtt ctgtgagaaa   2280

gtccttgtca gtgttctgaa aactgggaat taggaagtcg acttccaatc aagcttcaga   2340

tgacatgcga catgcgttaa gtttagaaat aacgttagtg tttctaattt agcatcgtgt   2400

tggagtccta attatgaaat gacattaaga aaattccatt cctcagaatt cttgtgcagt   2460

agcattgggt agaaacacca ttgtgttctg tgacctgggg tagggatgat atctcaaaaa   2520

cgcatgctca ggttgcccat ggtgatagct aaactgtctt ctcaggagag gagcaggctt   2580

tattaactgg aactcaccag atttcacaga acattttgaa gggcttagga ttgtgagttt   2640

ggaggtagat gccaagcaga ggtaaacatt ttgtataaca gaagaaacat atttgatatg   2700

ggagagagac agaaatcttg tggaaaactc cagagccatc aaagctggga cagtgttaaa   2760

gacgagcacc ctggaagtga ggagccaagt gtgggttttg aggaacagat atattaaggg   2820

ggattctcac aaatgtttta ttttgacaaa tatcaataat ttagaaaagt tgcaagaata   2880

gtatagcaat tattcatata ccccttccat atagtacaca gaaaaagagg gtatatattt   2940

taataaatat ttgtgtatac acattttgtg tatagatagg cagataaata gataaagaga   3000

caaatgtgca cctgtgtata attttctgaa ctgtttgaga attggttgta agcatcacga   3060

cacttcacca ccaaatactt cagcatgtgt ctcctaagaa caaggctgtt ctctacatga   3120

ccacaacata gttatttcac ccagaaactt aaacttgata caatacaata tctaatattc   3180

agtccatatt caaatttctc ctatcatcca aataatatca ttactaatct ccaatataaa   3240

gagatttaaa acatgttttc catgttcaac ataaatgtct tctccatttt tcttacaaaa   3300

tcatcaaaaa caactacgtt tcccatttat acttttacac cagtagtttc tttggaggaa   3360

cttgcacttg tcccacatcc agattggcag gggataaaat agaaataata agagctggca   3420

gaagagaggc tggttgatgc tgattacatt caaaataact atttggagga aaaagcactg   3480

attctgttcc tggggtgt                                                 3498


<210>  37
<211>  3352
<212>  DNA
<213>  Homo sapiens

<400>  37
ttagtctaaa ttagggatac acactcctcc ctgagctcta gacccctctc tctaactttc     60

actggatatc tccaccttga tagttcacca tgtctcaagt tcagttttgc tgaacctgaa    120

ctcataatct tcaccttaaa ctgcatcctc atccagcatt ccctaccttg gtgaccatga    180

tcaccaacct ctctcattgt aaaaacctgc ctaacacctt cccttccctc atcttccatc    240

tccagttcat tgctaagtgc tgatgttatt ctttaaatat gtcttaaagc aatctacttc    300

tctccatctt ggctcaggca ctttagtcca agctaccata acctatcctc tgaactactg    360

gcccacagaa tccactcttg cctctcccct aaaccattct ccaaaatgca ttccaagtat    420

tttttaaatt taactgaaaa tctgatcaca tcatgtgtct ttataaacac atcaatggct    480

tatccttaag ataaagacaa aagtcctaac atggcctata cagctctaca acatttttcc    540

atgcttattt ctcagctagc tacaatgttt tcctccatcc ctatgctcca gtcacaattc    600

cttcaatatg tccttgcttt gtcccacctc agagcttgcc acatgcagtt tcttctgact    660

cacatcccct tccttggaat gactgcctct cttttgatta gttaattttc tataatactg    720

cagacctcaa ctcaaatatc tcttgattcc ctcaaccacc agaccagatc agctctctca    780

ctatgcactt accatgtttt gaaattaata ctctctgaat tgtttatcac ctgtacctag    840

aatatagtgt atgatattta ttgggggggc tcaatatttt gagtggatga gtaaatatat    900

tacagatagc taattattca agatttcatg ttcacattat tgctaaaaat gtagatgaag    960

taaaagtaga ttgaaatagg aggatataaa catgttggcg ctctttacat cacatacatg   1020

gattatgttt ttctttgttt gtttttagat gaagtcttgc gctgtcaccc aggctggacg   1080

gcagtggccc gagtgcacag gcaacctctg cctcccaggt tcaagcgatt ctcctccctc   1140

agcctcccga gtagctggga ttacaggagc ccaccaccaa gcccagctaa tttttgtatt   1200

tttagtagag acggggtttc gccatgttgg ccaggctggt ctgaactgct gacctcaggt   1260

gatccacccg cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccatgcgcgg   1320

cccatggcat atgttatcag taatatgtaa gtatggcttc agtcaaagca aggaagttga   1380

aagtaacaat taaaaaaaaa aaagtcatca ggatccaaag ctgtggagaa aactcaacct   1440

ctgcctcctg ggttcaagca attctcctgc ctcagcctcc ctggtagctg ggattacagg   1500

tgcctgacac cacccccagc taatttttgt atttttagta gagacatggt ttcaccatgt   1560

tggtcaggct ggtcttgaac tcctgacctc aggtgatcca cccacctcag cctcccaaag   1620

tgctgggatt acaggcgtga gccactttta gaaaatgttt tcatctatct caatacctca   1680

ctacccctcc tgatattcca tctataatag caacagttgt gaaatgcact agattctaac   1740

attaacacta gatccattaa gaacagagca gaagagagtc tggatacaca aatttcacaa   1800

ttattggctc ccatcaacat atctaactca agcataaagt tgtttcagca gtagtttaag   1860

gttggttact aatgcaacac ctctttgcat gcaatggccc attaaattat cttcaacttt   1920

aaaaggttcc tttgttttta aatgcttata atgaacaaat atataccaat accttggcag   1980

aattcattaa cttaataact tcaatatgtt gttcatataa aaatttctgg taaatgagaa   2040

ctgtacatta ctgatgtgac aaggtacaca agccaatgtt gacataatgt tttcaaaatg   2100

gggtgtctgc tgtaactgaa ctaaatataa taactttatt caagaatgag tttcaatgat   2160

aggacaaaac ttgataaaat gaataaataa ataattatat gccagagttc agtaaaccct   2220

gtgtgtacac ctgaaaaagc tcaaacttgc ctagcacata tagagtccga attcagttgg   2280

gtttgtgtga aacgggtagg ttgagcccta aaaaagaggt agataaccca tataggcaga   2340

cttccttatt ttatttattt ttttctgctt cagcctcctg agtagctggg actacaggtg   2400

tgtgccacca cgtctggcta attttgtttg tttttagtag agatggggtt tcaccatatt   2460

ggccaggctg gtctcgaact cctgaccttg tgatctgcgc gcctcggcct cccaaagtgc   2520

tgggattaca ggcgtgagcc actgcgcctc gccaacttcc ttattttaaa tgccatttcc   2580

cactaaaaat aaaaccagta attctttgaa aaaaagttaa tattatgtat aggactggaa   2640

gtatataaga taaaactgga atatattgtc ataccagaaa tcaaagattt tgtcaaagac   2700

taatagttcc atgtcaaaaa gattcactaa tcaatttgca gaggctccca ctggccaaag   2760

atagagcttg atcatcaaca ggaataataa ctataatggg ttaaaacata gcaattatgt   2820

ttaaatctat aggtttatag taataatgtt aaaatcatta gtcacctttg aaagatgcta   2880

cgactcttta atccatcttg aattaatttt tgtataaggt gtaaggaagg gatccagttt   2940

cagctttcta catatggcta gccagttttc ccagcaccat ttattcaata gggaatcctt   3000

tccccattgc ttgtttttct caggtttgtc aaagatcaga tagttgtaga tatgcggtgt   3060

tatttctgag ggctctgttc tgttccattg atctatatct ctgttttggt accagtacca   3120

tgctgttttg gttactgtag ccttgtagta tagtttgaag tcaggttgca tgatgcctcc   3180

agctttgttc ttttggctta ggattgactt ggcaatgcgg gctccttttt ggttccatat   3240

gaactttaaa gtagtttttt ccaattctgt gaagaaagtc attggcagct tgatggggat   3300

gacattgaat ctataaatta ccttgggcag tatggccatt ttcacgatat tg           3352


