                         SEQUENCE LISTING

<110>  BRAHMS GmbH
 
<120>  Diagnostical use of Peroxiredoxin 4

<130>  B60446

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide derived from PRX4

<400>  2

Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu Glu Glu Cys 
1               5                   10              


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide derived from PRX4

<400>  3

Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala Ser 
1               5                   10                  15  


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide derived from PRX4

<400>  4

Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu Glu Glu Gly Gly Gly Glu 
1               5                   10                  15      


Thr Glu Glu Arg Pro Arg Thr Arg Glu Glu Glu 
            20                  25          


<210>  5
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  6
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210>  7
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
1               5                   10                  15      


Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
            20                  25                  30          


Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
        35                  40                  45              


Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala 
    50                  55                  60                  


Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly 
65                  70                  75                  80  


Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val 
                85                  90                  95      


Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
            100                 105                 110         


Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu 
        115                 120                 125             


Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile 
    130                 135                 140                 


Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu 
145                 150                 155                 160 


Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu 
                165                 170                 175     


Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn 
            180                 185                 190         


Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 
        195                 200                 205             


Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr 
    210                 215                 220                 


His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile 
225                 230                 235                 240 


Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln 
                245                 250                 255     


<210>  8
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  9
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
1               5                   10                  15      


Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
            20                  25                  30          


Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
        35                  40                  45              


Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala 
    50                  55                  60                  


Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly 
65                  70                  75                  80  


Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val 
                85                  90                  95      


Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
            100                 105                 110         


Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu 
        115                 120                 125             


Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile 
    130                 135                 140                 


Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu 
145                 150                 155                 160 


Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu 
                165                 170                 175     


Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn 
            180                 185                 190         


Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 
        195                 200                 205             


Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr 
    210                 215                 220                 


His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile 
225                 230                 235                 240 


Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln 
                245                 250                 255     


