                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  BACE1 Inhibitory Antibodies

<130>  BDS/ABB/V312

<150>  EP09162713.3
<151>  2009-06-15

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Ala Leu Pro Trp Leu Leu Leu Trp Met Gly Ala Gly Val 
1               5                   10                  15      


Leu Pro Ala His Gly Thr Gln His Gly Ile Arg Leu Pro Leu Arg Ser 
            20                  25                  30          


Gly Leu Gly Gly Ala Pro Leu Gly Leu Arg Leu Pro Arg Glu Thr Asp 
        35                  40                  45              


Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val Glu Met Val 
    50                  55                  60                  


Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val Glu Met Thr 
65                  70                  75                  80  


Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp Thr Gly Ser 
                85                  90                  95      


Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu His Arg Tyr 
            100                 105                 110         


Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val 
        115                 120                 125             


Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp 
    130                 135                 140                 


Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg Ala Asn Ile 
145                 150                 155                 160 


Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly Ser Asn Trp 
                165                 170                 175     


Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg Pro Asp Asp 
            180                 185                 190         


Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr His Val Pro 
        195                 200                 205             


Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro Leu Asn Gln 
    210                 215                 220                 


Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile Gly Gly Ile 
225                 230                 235                 240 


Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro Ile Arg Arg 
                245                 250                 255     


Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile Asn Gly Gln 
            260                 265                 270         


Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys Ser Ile Val 
        275                 280                 285             


Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val Phe Glu Ala 
    290                 295                 300                 


Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys Phe Pro Asp 
305                 310                 315                 320 


Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala Gly Thr Thr 
                325                 330                 335     


Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met Gly Glu Val 
            340                 345                 350         


Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln Tyr Leu Arg 
        355                 360                 365             


Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr Lys Phe Ala 
    370                 375                 380                 


Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val Ile Met Glu 
385                 390                 395                 400 


Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile Gly Phe Ala 
                405                 410                 415     


Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr Ala Ala Val Glu 
            420                 425                 430         


Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr Asn Ile Pro 
        435                 440                 445             


Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr Val Met Ala Ala 
    450                 455                 460                 


Ile Cys Ala Leu Phe Met Leu Pro Leu Cys Leu Met Val Cys Gln Trp 
465                 470                 475                 480 


Arg Cys Leu Arg Cys Leu Arg Gln Gln His Asp Asp Phe Ala Asp Asp 
                485                 490                 495     


Ile Ser Leu Leu Lys 
            500     


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        195                 200                 205             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    210                 215                 220                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
225                 230                 235                 240 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                245                 250                 255     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            260                 265                 270         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        275                 280                 285             


Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met 
    290                 295                 300                 


Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln 
305                 310                 315                 320 


Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr 
                325                 330                 335     


Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val 
            340                 345                 350         


Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile 
        355                 360                 365             


Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr Ala 
    370                 375                 380                 


Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr 
385                 390                 395                 400 


Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr 
                405                 410                 415 


<210>  3
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        195                 200                 205             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    210                 215                 220                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
225                 230                 235                 240 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                245                 250                 255     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            260                 265                 270         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        275                 280                 285             


Gly Thr Thr Pro Trp Asn 
    290                 


<210>  4
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile 
        195 


<210>  5
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro Ile Arg 
1               5                   10                  15      


Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile Asn Gly 
            20                  25                  30          


Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys Ser Ile 
        35                  40                  45              


Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val Phe Glu 
    50                  55                  60                  


Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys Phe Pro 
65                  70                  75                  80  


Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala Gly Thr 
                85                  90                  95      


Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met Gly Glu 
            100                 105                 110         


Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln Tyr Leu 
        115                 120                 125             


Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr Lys Phe 
    130                 135                 140                 


Ala Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val Ile Met 
145                 150                 155                 160 


Glu Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile Gly Phe 
                165                 170                 175     


Ala Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr Ala Ala Val 
            180                 185                 190         


Glu Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr Asn Ile 
        195                 200                 205             


Pro Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr 
    210                 215                 220     


<210>  6
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met Gly Glu Val Thr Asn 
1               5                   10                  15      


Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln Tyr Leu Arg Pro Val 
            20                  25                  30          


Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr Lys Phe Ala Ile Ser 
        35                  40                  45              


Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val Ile Met Glu Gly Phe 
    50                  55                  60                  


Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile Gly Phe Ala Val Ser 
65                  70                  75                  80  


Ala Cys His Val His Asp Glu Phe Arg Thr Ala Ala Val Glu Gly Pro 
                85                  90                  95      


Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr Asn Ile Pro Gln Thr 
            100                 105                 110         


Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr 
        115                 120         


<210>  7
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        195                 200                 205             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    210                 215                 220                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
225                 230                 235                 240 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                245                 250                 255     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            260                 265                 270         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        275                 280                 285             


Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met 
    290                 295                 300                 


Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln 
305                 310                 315                 


<210>  8
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        195                 200                 205             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    210                 215                 220                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
225                 230                 235                 240 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                245                 250                 255     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            260                 265                 270         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        275                 280                 285             


Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met 
    290                 295                 300                 


<210>  9
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Thr Glu Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val 
1               5                   10                  15      


Cys Trp Gln Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser 
            20                  25                  30          


Leu Tyr Leu Met Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile 
        35                  40                  45              


Leu Pro Gln Gln Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln 
    50                  55                  60                  


Asp Asp Cys Tyr Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val 
65                  70                  75                  80  


Met Gly Ala Val Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala 
                85                  90                  95      


Arg Lys Arg Ile Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu 
            100                 105                 110         


Phe Arg Thr Ala Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu 
        115                 120                 125             


Asp Cys Gly Tyr Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr 
    130                 135                 140                 


Ile Ala Tyr 
145         


<210>  10
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Cys Trp Gln Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile 
1               5                   10                  15      


Ser Leu Tyr Leu Met Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr 
            20                  25                  30          


Ile Leu Pro Gln Gln Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser 
        35                  40                  45              


Gln Asp Asp Cys Tyr Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr 
    50                  55                  60                  


Val Met Gly Ala Val Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg 
65                  70                  75                  80  


Ala Arg Lys Arg Ile Gly Phe Ala Val Ser Ala Cys His Val His Asp 
                85                  90                  95      


Glu Phe Arg Thr Ala Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met 
            100                 105                 110         


Glu Asp Cys Gly Tyr Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met 
        115                 120                 125             


Thr Ile Ala Tyr 
    130         


<210>  11
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Gln Asp Asp 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Ala Ala Ala 
1               


<210>  13
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe 
1               5                   10                  15      


Val Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr 
            20                  25                  30          


Val Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val 
        35                  40                  45              


Asp Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe 
    50                  55                  60                  


Leu His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu 
65                  70                  75                  80  


Arg Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu 
                85                  90                  95      


Leu Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val 
            100                 105                 110         


Arg Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn 
        115                 120                 125             


Gly Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala 
    130                 135                 140                 


Arg Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln 
145                 150                 155                 160 


Thr His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe 
                165                 170                 175     


Pro Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile 
            180                 185                 190         


Ile Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr 
        195                 200                 205             


Pro Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu 
    210                 215                 220                 


Ile Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp 
225                 230                 235                 240 


Lys Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys 
                245                 250                 255     


Val Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu 
            260                 265                 270         


Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln 
        275                 280                 285             


Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu 
    290                 295                 300                 


Met Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln 
305                 310                 315                 320 


Gln Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys 
                325                 330                 335     


Tyr Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala 
            340                 345                 350         


Val Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg 
        355                 360                 365             


Ile Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr 
    370                 375                 380                 


Ala Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly 
385                 390                 395                 400 


Tyr Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr 
                405                 410                 415     


<210>  14
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Thr Glu Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val 
1               5                   10                  15      


<210>  15
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Thr Glu Lys Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val 
1               5                   10                  15      


Cys Trp Gln Ala Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile 
            20                  25                  30      


<210>  16
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Thr Asp Glu Glu Pro Glu Glu Pro Gly Arg Arg Gly Ser Phe Val 
1               5                   10                  15      


Glu Met Val Asp Asn Leu Arg Gly Lys Ser Gly Gln Gly Tyr Tyr Val 
            20                  25                  30          


Glu Met Thr Val Gly Ser Pro Pro Gln Thr Leu Asn Ile Leu Val Asp 
        35                  40                  45              


Thr Gly Ser Ser Asn Phe Ala Val Gly Ala Ala Pro His Pro Phe Leu 
    50                  55                  60                  


His Arg Tyr Tyr Gln Arg Gln Leu Ser Ser Thr Tyr Arg Asp Leu Arg 
65                  70                  75                  80  


Lys Gly Val Tyr Val Pro Tyr Thr Gln Gly Lys Trp Glu Gly Glu Leu 
                85                  90                  95      


Gly Thr Asp Leu Val Ser Ile Pro His Gly Pro Asn Val Thr Val Arg 
            100                 105                 110         


Ala Asn Ile Ala Ala Ile Thr Glu Ser Asp Lys Phe Phe Ile Asn Gly 
        115                 120                 125             


Ser Asn Trp Glu Gly Ile Leu Gly Leu Ala Tyr Ala Glu Ile Ala Arg 
    130                 135                 140                 


Pro Asp Asp Ser Leu Glu Pro Phe Phe Asp Ser Leu Val Lys Gln Thr 
145                 150                 155                 160 


His Val Pro Asn Leu Phe Ser Leu Gln Leu Cys Gly Ala Gly Phe Pro 
                165                 170                 175     


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            180                 185                 190         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        195                 200                 205             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    210                 215                 220                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
225                 230                 235                 240 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                245                 250                 255     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            260                 265                 270         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        275                 280                 285             


Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met 
    290                 295                 300                 


Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln 
305                 310                 315                 320 


Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr 
                325                 330                 335     


Lys Phe Ala Ile Ser Gln Ser Ser Thr 
            340                 345 


