                         SEQUENCE LISTING

<110>  Cilian AG
 
<120>  Method for the expression of a viral protein in a protozoan

<130>  CD 40333

<150>  EP 0910357.3
<151>  2009-06-17

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1697
<212>  DNA
<213>  Influenza virus

<400>  1
atgaaagcaa aactactggt cctgttatgt acatttacag ctacatatgc agacacaata       60

tgtataggct accatgccaa caactcaacc gacactgttg acacagtact tgagaagaat      120

gtgacagtga cacactctgt caacctactt gaggacagtc acaatggaaa actatgtcta      180

ctaaaaggaa tagccccact acaattgggt aattgcagcg ttgccggatg gatcttagga      240

aacccagaat gcgaattact gatttccaag gaatcatggt cctacattgt agaaacacca      300

aatcctgaga atggaacatg ttacccaggg tatttcgccg actatgagga actgagggag      360

caattgagtt cagtatcttc atttgagaga ttcgaaatat tccccaaaga aagctcatgg      420

cccaaccaca ccgtaaccgg agtatcagca tcatgctccc ataatgggaa aagcagtttt      480

tacagaaatt tgctatggct gacggggaag aatggtttgt acccaaacct gagcaagtcc      540

tatgtaaaca acaaagagaa agaagtcctt gtactatggg gtgttcatca cccgcctaac      600

atagggaacc aaagggccct ctatcataca gaaaatgctt atgtctctgt agtgtcttca      660

cattatagca gaagattcac cccagaaata gccaaaagac ccaaagtaag agatcaggaa      720

ggaagaatca actactactg gactctgctg gaacctgggg atacaataat atttgaggca      780

aatggaaatc taatagcgcc atggtatgct tttgcactga gtagaggctt tggatcagga      840

atcatcacct caaatgcacc aatggatgaa tgtgatgcga agtgtcaaac acctcaggga      900

gctataaaca gcagtcttcc tttccagaat gtacacccag tcacaatagg agagtgtcca      960

aagtatgtca ggagtgcaaa attaaggatg gttacaggac taaggaacat cccatccatt     1020

caatccagag gtttgtttgg agccattgcc ggtttcattg aaggggggtg gactggaatg     1080

gtagatgggt ggtatggtta tcatcatcag aatgagcaag gatctggcta tgctgcagat     1140

caaaaaagta cacaaaatgc cattaacggg attacaaaca aggtgaattc tgtaattgag     1200

aaaatgaaca ctcaattcac agctgtgggc aaagaattca acaaattgga aagaaggatg     1260

gaaaacttaa ataaaaaagt tgatgatggg tttctagaca tttggacaat aatgcagaat     1320

tgttggttct actggaaaat gaaaggactt tggatttcca tgactccaat gtgaagaatc     1380

tgtatgagaa agtaaaaagc caattaaaga ataatgccaa agaaatagga aacgggtgtt     1440

ttgaattcta tcacaagtgt aacaatgaat gcatggagag tgtgaaaaat ggaacttatg     1500

actatccaaa atattccgaa gaatcaaagt taaacaggga gaaaattgat ggagtgaaat     1560

tggaatcaat gggagtctat cagattctgg cgatctactc aactgtcgcc agttccctgg     1620

ttcttttggt ctccctgggg gcaatcagct tctggatgtg ttccaatggg tctttgcagt     1680

gtagaatatg catctga                                                    1697


<210>  2
<211>  1698
<212>  DNA
<213>  Influenza virus

<400>  2
atgaaagcta agttattagt tttactttgt actttcactg ctacttatgc tgatactatt       60

tgtattggtt atcacgctaa taattctact gatactgttg atactgtttt agaaaaaaat      120

gttactgtta ctcactctgt taatctttta gaagattctc acaatggtaa attatgttta      180

cttaaaggta ttgctccttt ataacttggt aattgttctg ttgctggttg gattcttggt      240

aatcctgaat gtgaattact tatttctaaa gaatcttggt cttatattgt tgaaactcct      300

aatcctgaaa atggtacttg ttatcctggt tatttcgctg attatgaaga attaagagaa      360

taactttctt ctgtttcttc atttgaaaga ttcgaaattt tccctaaaga atcttcttgg      420

cctaatcaca ctgttactgg tgtttctgct tcttgttctc ataatggtaa atcttcattc      480

tatagaaatc ttttatggtt aactggtaaa aatggtttat atcctaatct ttctaaatct      540

tatgttaata ataaggaaaa agaagtttta gttctttggg gtgttcacca ccctcctaat      600

attggtaatt aaagagcttt atatcacact gaaaatgctt atgtttctgt tgtttcttct      660

cactattcta gaagattcac tcctgaaatt gctaaaagac ctaaagttag agattaagaa      720

ggtagaatta actattattg gactttatta gaacctggtg atactattat tttcgaagct      780

aatggtaatc ttattgctcc ttggtacgct ttcgctttat ctagaggttt cggttctggt      840

attattactt ctaatgctcc tatggatgaa tgtgatgcta aatgttaaac tccttaaggt      900

gctattaatt cttctttacc tttctaaaac gttcaccctg ttactattgg tgaatgtcct      960

aaatatgtta gatcagctaa attaagaatg gttactggtt taagaaatat tccttctatc     1020

taatctagag gacttttcgg tgctattgct ggtttcattg agggaggatg gacaggtatg     1080

gttgatggtt ggtacggtta tcaccaccaa aatgaataag gttctggtta tgctgctgat     1140

taaaagtcta ctcaaaacgc tattaatggt attactaaca aagttaattc tgttattgaa     1200

aaaatgaata cttaattcac tgctgttggt aaagaattca ataagttaga aagaagaatg     1260

gaaaatctta ataagaaagt tgatgatggt ttcttagata tttggactta taatgctgaa     1320

ttattagttc ttttagaaaa tgaaagaact ttagatttcc acgattctaa tgttaaaaat     1380

ctttatgaaa aagttaaatc ttaacttaag aataatgcta aagaaattgg taatggttgt     1440

ttcgaattct atcacaaatg taataatgaa tgtatggaat ctgttaagaa tggtacttat     1500

gattatccta aatattctga agaatctaag ttaaatagag aaaaaattga tggtgttaaa     1560

ttagaatcta tgggagttta ctaaattctt gctatctatt ctactgttgc ttcttcttta     1620

gttttattag tttctttagg tgctatttct ttctggatgt gttctaatgg ttctttataa     1680

tgtagaattt gtatttga                                                   1698


<210>  3
<211>  550
<212>  PRT
<213>  Influenza virus

<400>  3

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Thr His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser 
545                 550 


<210>  4
<211>  1604
<212>  DNA
<213>  Influenza virus

<400>  4
ggcgcgccat ggatatcaaa gctaagttat tagttttact ttgtactttc actgctactt       60

atgctgatac tatttgtatt ggttatcacg ctaataattc tactgatact gttgatactg      120

ttttagaaaa aaatgttact gttactcact ctgttaatct tttagaagat tctcacaatg      180

gtaaattatg tttacttaaa ggtattgctc ctttataact tggtaattgt tctgttgctg      240

gttggattct tggtaatcct gaatgtgaat tacttatttc taaagaatct tggtcttata      300

ttgttgaaac tcctaatcct gaaaatggta cttgttatcc tggttatttc gctgattatg      360

aagaattaag agaataactt tcttctgttt cttcatttga aagattcgaa attttcccta      420

aagaatcttc ttggcctaat cacactgtta ctggtgtttc tgcttcttgt tctcataatg      480

gtaaatcttc attctataga aatcttttat ggttaactgg taaaaatggt ttatatccta      540

atctttctaa atcttatgtt aataataagg aaaaagaagt tttagttctt tggggtgttc      600

accaccctcc taatattggt aattaaagag ctttatatca cactgaaaat gcttatgttt      660

ctgttgtttc ttctcactat tctagaagat tcactcctga aattgctaaa agacctaaag      720

ttagagatta agaaggtaga attaactatt attggacttt attagaacct ggtgatacta      780

ttattttcga agctaatggt aatcttattg ctccttggta cgctttcgct ttatctagag      840

gtttcggttc tggtattatt acttctaatg ctcctatgga tgaatgtgat gctaaatgtt      900

aaactcctta aggtgctatt aattcttctt tacctttcta aaacgttcac cctgttacta      960

ttggtgaatg tcctaaatat gttagatcag ctaaattaag aatggttact ggtttaagaa     1020

atattccttc tatctaatct agaggacttt tcggtgctat tgctggtttc attgagggag     1080

gatggacagg tatggttgat ggttggtacg gttatcacca ccaaaatgaa taaggttctg     1140

gttatgctgc tgattaaaag tctactcaaa acgctattaa tggtattact aacaaagtta     1200

attctgttat tgaaaaaatg aatacttaat tcactgctgt tggtaaagaa ttcaataagt     1260

tagaaagaag aatggaaaat cttaataaga aagttgatga tggtttctta gatatttgga     1320

cttataatgc tgaattatta gttcttttag aaaatgaaag aactttagat ttccacgatt     1380

ctaatgttaa aaatctttat gaaaaagtta aatcttaact taagaataat gctaaagaaa     1440

ttggtaatgg ttgtttcgaa ttctatcaca aatgtaataa tgaatgtatg gaatctgtta     1500

agaatggtac ttatgattat cctaaatatt ctgaagaatc taagttaaat agagaaaaaa     1560

ttgatggtgt taaattagaa tctatgggag tttactaaat ttga                      1604


<210>  5
<211>  538
<212>  PRT
<213>  Influenza virus

<400>  5

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Thr His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser 
    530                 535             


<210>  6
<211>  1032
<212>  DNA
<213>  Influenza virus

<400>  6
atcaaagcta agttattagt tttactttgt actttcactg ctacttatgc tgatactatt       60

tgtattggtt atcacgctaa taattctact gatactgttg atactgtttt agaaaaaaat      120

gttactgtta ctcactctgt taatctttta gaagattctc acaatggtaa attatgttta      180

cttaaaggta ttgctccttt ataacttggt aattgttctg ttgctggttg gattcttggt      240

aatcctgaat gtgaattact tatttctaaa gaatcttggt cttatattgt tgaaactcct      300

aatcctgaaa atggtacttg ttatcctggt tatttcgctg attatgaaga attaagagaa      360

taactttctt ctgtttcttc atttgaaaga ttcgaaattt tccctaaaga atcttcttgg      420

cctaatcaca ctgttactgg tgtttctgct tcttgttctc ataatggtaa atcttcattc      480

tatagaaatc ttttatggtt aactggtaaa aatggtttat atcctaatct ttctaaatct      540

tatgttaata ataaggaaaa agaagtttta gttctttggg gtgttcacca ccctcctaat      600

attggtaatt aaagagcttt atatcacact gaaaatgctt atgtttctgt tgtttcttct      660

cactattcta gaagattcac tcctgaaatt gctaaaagac ctaaagttag agattaagaa      720

ggtagaatta actattattg gactttatta gaacctggtg atactattat tttcgaagct      780

aatggtaatc ttattgctcc ttggtacgct ttcgctttat ctagaggttt cggttctggt      840

attattactt ctaatgctcc tatggatgaa tgtgatgcta aatgttaaac tccttaaggt      900

gctattaatt cttctttacc tttctaaaac gttcaccctg ttactattgg tgaatgtcct      960

aaatatgtta gatcagctaa attaagaatg gttactggtt taagaaatat tccttctatc     1020

taatctagat ga                                                         1032


<210>  7
<211>  343
<212>  PRT
<213>  Influenza virus

<400>  7

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Thr His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg 
            340             


<210>  8
<211>  328
<212>  DNA
<213>  Tetrahymena thermophila

<400>  8
atgaacaaga ctctcatctt agctttagtt ggtgttttgg ctttaactgc caccaccttg       60

gttgctttcc acaaccactc tcacaacatc agagttgact aagaccccgc cactctcttc      120

aagcaattca agcaaactta caataagaag tatgctgatc ctactttcga aacctacaga      180

ttcggtgtct tcacccaaaa cttagaaatc gtcaagactg actctacttt cggtgtcacc      240

taattcatgg acttaactcc tgctgaattc gctcaacaat tcctcacttt acacgaaaag      300

gttaacagca ccgaagttta cagagctc                                         328


<210>  9
<211>  113
<212>  PRT
<213>  Tetrahymena thermophila

<400>  9

Met Asn Lys Thr Leu Ile Leu Ala Leu Val Val Val Leu Ala Leu Thr 
1               5                   10                  15      


Ala Thr Thr Leu Val Ala Phe His Asn His Ser His Asn Ile Arg Val 
            20                  25                  30          


Asp Gln Asp Pro Ala Thr Leu Phe Lys Gln Phe Lys Gln Thr Tyr Asn 
        35                  40                  45              


Lys Lys Tyr Ala Asp Ala Thr Phe Glu Thr Tyr Arg Phe Gly Val Phe 
    50                  55                  60                  


Thr Gln Asn Leu Glu Ile Val Lys Thr Asp Ser Thr Phe Gly Val Thr 
65                  70                  75                  80  


Gln Phe Met Asp Leu Thr Pro Ala Glu Phe Ala Gln Gln Phe Leu Thr 
                85                  90                  95      


Leu His Glu Lys Val Asn Ser Thr Glu Val Tyr Arg Ala Gln Gly Glu 
            100                 105                 110         


Ala 
    


<210>  10
<211>  65
<212>  DNA
<213>  Influenza virus

<400>  10
ggcgcgccat ggatatcaaa gctaagttat tagttttact ttgtactttc actgctactt       60

atgct                                                                   65


<210>  11
<211>  17
<212>  PRT
<213>  Influenza virus

<400>  11

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  980
<212>  DNA
<213>  Tetrahymena thermophila

<400>  12
agcatgcttt ttcatgtact attcctaact atagcttaat gctttataca tcaaagtatg       60

aagaagacag gttttaaaaa accaaaaaat atgtttttta tttgaaaagt attatatagg      120

aataataaat gctgcataaa tactctaagt agttgataaa aaatctattt atgcaaagaa      180

aaatttagaa aaatttagaa aaacaaagaa aataattgtt attataaagc attttgttta      240

ctaagcaaaa gatataaaat ttgagataga aatatacata caagattaac gttttgtttg      300

tgctttgaaa attgaaatat ttaattatta aatctgctaa cttttttaga tatttatttg      360

ctttatttta ttttttaaat ttttgcaaag tggagaaaaa tgaaacaatc aatctttttt      420

ttataaataa tataaatggt attaagccta atttttattg ctggagagtg ttattcaaat      480

atattgctga atgtggctag atggaattcg ctttggaagg aaagtgttta taaaataagt      540

gatgtattat agcacattgc taattattat aaagaatgta ttggatattt aaaaattaga      600

aaataaaatt tagctgaaaa gtaagaaagc aagcaaagat atatatatat atatggagat      660

gataaaaaga taaattcgaa aaaagaaaat ttctaaagtg aaaagaatta tggatttgat      720

taaataaaaa tatttttaga atgggctgat taaagaggga tcttcgagaa tgaaatgatt      780

tagaaaaaaa gaaagaaaga ttataacatc tacaaagagt tgaagattct agaagaggag      840

gaataattag ctatcagtct tattaaaaga tatcgcaaaa caagaaatat ttttgaaatt      900

aattaaaaaa tttaaaaaac aaaagataaa aattttgcac aaaaaagcaa ttaattaaaa      960

aaaaagatat atcataagaa                                                  980


<210>  13
<211>  998
<212>  DNA
<213>  Tetrahymena thermophila

<400>  13
tcgaggataa gtaatatatt tagtgcacaa tgtttgaatg tttttttgat aaatttgtaa       60

attaaatcta tttaagtcag tagaatttta gatattttca tagatttttt aataagtaga      120

caatttattt ctaaaaaata tttaaaaata aaaaataata agggttttga ataactcctt      180

taatttaaat acacattttt aaattttttt tagctcttta aatattcata aaaataaaaa      240

ataactaact aaaaataaat aaaaagataa taatgattaa aggtataata ctgaataaga      300

aaaaacataa tagagtactt attttttata tcactatttt taatatcttg aaagcaaaac      360

ttttttatat atcttaaaat atattgtatc gtttattcaa ttattttctt taaatttcaa      420

atatattgat aaaaaagatg acatgttttt taaagaaaac atgaaatata aaatagataa      480

atatcaatta ttttatttat taaatatata agctgctcaa aacatagctc attcatcaat      540

tataatatgt gaatcattaa ttttcaaaat attactcatt atttaggcta tcatttattt      600

tttattttca attatccgtt tctattatat tttaatatta agttgtgatt cttgaatttt      660

gtgtcatgaa ttatttgtaa atctttttat ttctgataaa aaatataaat tgattgactc      720

atgatttaaa tcatgagtca acctaactaa ttttcaaaat tcttctattc taaaatatag      780

atgtgattct tgaatctctc ttgaatataa agtaattttt tatatttctg atataattct      840

tagctacgtg attcacgatt tatgcaatga tccatataaa ataatgtaaa tagtgtatat      900

atatatattc gtctttttta ttctttatat aatttaaaaa aattaaaaaa atttaataaa      960

gctctaataa aataaataat aatactaaac ttaaaata                              998


<210>  14
<211>  1722
<212>  DNA
<213>  Influenza virus

<400>  14
atgaaggcaa taattgtact actcatggta gtaacatcca atgcagatcg aatctgcact       60

ggaataacat cttcaaactc acctcatgtg gtcaaaacag ccactcaagg ggaggtcaat      120

gtgactggtg tgataccact aacaacaaca ccaacaaaat cttattttgc aaatctcaaa      180

ggaacaagga ccagagggaa actatgccca gactgtctca actgcacaga tctggatgtg      240

gctttgggca gaccaatgtg tgtggggacc acaccttcgg cgaaagcttc aatactccac      300

gaagtcaaac ctgttacatc cgggtgcttt cctataatgc acgacagaac aaaaatcagg      360

caactaccca atcttctcag aggatatgaa aatatcaggc tatcaaccca aaacgtcatc      420

gatgcggaaa aggcaccagg aggaccctac agacttggaa cctcaggatc ttgccctaac      480

gctaccagta agagcggatt tttcgcaaca atggcttggg ctgtcccaaa ggacaacaac      540

aaaaatgcaa cgaacccact aacagtagaa gtaccataca tttgtacaga aggggaagac      600

caaatcactg tttgggggtt ccattcagat gacaaaaccc aaatgaagaa cctctatgga      660

gactcaaatc ctcaaaagtt cacctcatct gctaatggag taaccacaca ctatgtttct      720

cagattggca gcttcccaga tcaaacagaa gacggaggac taccacaaag cggcaggatt      780

gttgttgatt acatgatgca aaaacctggg aaaacaggaa caattgtcta ccaaagaggt      840

gttttgttgc ctcaaaaggt gtggtgcgcg agtggcagga gcaaagtaat aaaagggtcc      900

ttgcctttaa ttggtgaagc agattgcctt catgaaaaat acggtggatt aaacaaaagc      960

aagccttact acacaggaga acatgcaaaa gccataggaa attgcccaat atgggtgaaa     1020

acacctttga agcttgccaa tggaaccaaa tatagacctc ctgcaaaact attaaaggaa     1080

aggggtttct tcggagctat tgctggtttc ctagaaggag gatgggaagg aatgattgca     1140

ggctggcacg gatacacatc tcacggagca catggagtgg cagtggcggc ggaccttaag     1200

agtacgcaag aagctataaa caagataaca aaaaatctca attctttgag tgagctagaa     1260

gtaaagaatc ttcaaagact aagtggtgcc atggatgaac tccacaacga aatactcgag     1320

ctggatgaga aagtggatga tctcagagct gacactataa gctcgcaaat agaacttgca     1380

gtcttgcttt ccaacgaagg aataataaac agtgaagatg agcatctatt ggcacttgag     1440

agaaaactaa agaaaatgct gggtccctct gctgtagaga taggaaatgg atgcttcgaa     1500

accaaacaca agtgcaacca gacctgctta gacaggatag ctgctggcac ctttaatgca     1560

ggagaatttt ctctccccac ttttgattca ctgaacatta ctgctgcatc tttaaatgat     1620

gatggattgg ataaccatac tatactgctc tattactcaa ctgctgcttc tagtttggct     1680

gtaacattga tgctagctat ttttattgtt tatatggtct cc                        1722


<210>  15
<211>  574
<212>  PRT
<213>  Influenza virus

<400>  15

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asp Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Ser Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser 
                565                 570                 


