                         SEQUENCE LISTING

<110>  The Babraham Institute
 
<120>  COMPOSITION AND USES THEREOF

<130>  BAB-C-P967PCT

<150>  0909792.4
<151>  2009-06-08

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Murine

<400>  1
gcagccgaga tggaaggaat t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Murine

<400>  2
ttcgtcggct ctaccttcct t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Murine

<400>  3
gcaatggatg ccaagccagt t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Murine

<400>  4
ttcgttacct acggttcggt c                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Murine

<400>  5
cgccttcaga tctccagtct t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Murine

<400>  6
ttgcggaagt ctagaggtca g                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Murine

<400>  7
gaactcgaag aagccccagt t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Murine

<400>  8
ttcttgagct tcttcggggt c                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Murine

<400>  9
cccagtccgc aacttcttct t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Murine

<400>  10
ttgggtcagg cgttgaagaa g                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Murine

<400>  11
gctgcttcgg tctatccgat t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Murine

<400>  12
ttcgacgaag ccagataggc t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Murine

<400>  13
ggccaaggat cctatggagt t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Murine

<400>  14
ttccggttcc taggatacct c                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Murine

<400>  15
gctcatcgac aagcaactgt t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Murine

<400>  16
ttcgagtagc tgttcgttga c                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Murine

<400>  17
gatggactac atgtgtacat t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Murine

<400>  18
ttctacctga tgtacacatg t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Human

<400>  19
atacagccct ccaccagaat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Human

<400>  20
tttatgtcgg gaggtggtct t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Human

<400>  21
gcagtcaact tctcttacat t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Human

<400>  22
ttcgtcagtt gaagagaatg t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Human

<400>  23
agacctcctt ctaacttcat t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Human

<400>  24
tttctggagg aagattgaag t                                                 21


<210>  25
<211>  2353
<212>  DNA
<213>  Human

<400>  25
aggatagacc aaggaagagg ggctgggggg cagcctgggg gcatgaaaag tggccaggaa       60

ggagccaaga ctccaccagc aacaattgag ttgcttcagc ctcagtctag ggttccttcc      120

aggccttgaa ccccccaacc tcacaagggt tggaaagtga ggccggtgaa ctttccagct      180

ggtactttga ttttaaaata ataataataa ttttttcacc ctagttcggt tgggtgctcc      240

atcttacgga gccccaaact tattttgaga ggccgccacc gtgttatggg cgtgcgcaac      300

tgcctctacg gcaataatat gtcaggacaa cgcgatatcc cccctgaaat cggggaacag      360

cccgagcaac cacctttgga ggccccaggg gcagctgccc ccggtgctgg gcctagccca      420

gccgaagaga tggagaccga accgcctcac aacgagccca tccccgtcga gaatgatggc      480

gaggcctgtg gacccccaga ggtctccaga cccaactttc aggtcctcaa cccggcattc      540

agggaagctg gagcccatgg aagctacagc ccacctcctg aggaagcaat gcccttcgag      600

gctgaacagc ccagcttggg aggcttctgg cctacactgg agcagcctgg attccccagt      660

ggggtccatg caggccttga ggccttcggc ccagcactca tggagcccgg agccttcagt      720

ggtgccagac caggcctggg aggatacagc cctccaccag aagaagctat gccctttgag      780

tttgaccagc ctgcccagag aggctgcagt caacttctct tacaggtccc agaccttgct      840

ccaggaggcc caggtgctgc aggggtcccc ggagctcctc ccgaggagcc ccaagccctc      900

aggcctgcaa aggctggctc cagaggaggc tacagccctc cccctgagga gactatgcca      960

tttgagcttg atggagaagg atttggggac gacagcccac ccccggggct ttcccgagtt     1020

atcgcacaag tcgacggcag cagccagttc gcggcagtcg cggcctcgag tgcggtccgc     1080

ctcactcccg ccgcgaacgc gcctcccctc tgggtcccag gcgccatcgg cagcccatcc     1140

caagaggctg tcagacctcc ttctaacttc acgggcagca gcccctggat ggagatctcc     1200

ggacccccgt tcgagattgg cagcgccccc gctggggtcg acgacactcc cgtcaacatg     1260

gacagccccc caatcgcgct tgacggcccg cccatcaagg tctccggagc cccagataag     1320

agagagcgag cagagagacc cccagttgag gaggaagcag cagagatgga aggagccgct     1380

gatgccgcgg agggaggaaa agtaccctct ccggggtacg gatcccctgc cgccggggca     1440

gcctcagcgg ataccgctgc cagggcagcc cctgcagccc cagccgatcc tgactccggg     1500

gcaaccccag aagatcccga ctccgggaca gcaccagccg atcctgactc cggggcattc     1560

gcagccgatc ccgactccgg ggcagcccct gccgccccag ccgatcccga ctccggggcg     1620

gcccctgacg ccccagccga tcccgactcc ggggcggccc ctgacgcccc agccgatcca     1680

gatgccgggg cggcccctga ggctcccgcc gcccctgcgg ctgctgagac ccgggcagcc     1740

catgtcgccc cagctgcgcc agacgcaggg gctcccactg ccccagccgc ttctgccacc     1800

cgggcagccc aagtccgccg ggcggcctct gcagcccctg cctccggggc cagacgcaag     1860

atccatctca gaccccccag ccccgagatc caggctgccg atccgcctac tccgcggcct     1920

actcgcgcgt ctgcctggcg gggcaagtcc gagagcagcc gcggccgccg cgtgtactac     1980

gatgaagggg tggccagcag cgacgatgac tccagcggag acgagtccga cgatgggacc     2040

tccggatgcc tccgctggtt tcagcatcgg cgaaatcgcc gccgccgaaa gccccagcgc     2100

aacttactcc gcaactttct cgtgcaagcc ttcgggggct gcttcggtcg atctgagagt     2160

ccccagccca aagcctcgcg ctctctcaag gtcaagaagg tacccctggc ggagaagcgc     2220

agacagatgc gcaaagaagc cctggagaag cgggcccaga agcgcgcaga gaagaaacgc     2280

agtaagctca tcgacaaaca actccaggac gaaaagatgg gctacatgtg tacgcaccgc     2340

ctgctgcttc tag                                                        2353


<210>  26
<211>  1447
<212>  DNA
<213>  Murine

<400>  26
atggagatca ccagacccct gcttgagatt ggcagagcct ccattggggt cgacgacgac       60

accgctgtca atatggacag ccccccaatc gcaagtgatg gcccgcccat cgaagtctcg      120

ggagccccag ataagagcga gtgcgcagag agacccccag ttgagcgaga agcagccgag      180

atggaaggaa gccctaccac cgccactgcg gtggaaggaa aagtcccctc tccggagaga      240

ggggacggat cttccaccca gcctgaagca atggatgcca agccagcccc tgctgcccaa      300

gccgtctcta ccggatctga tgctggagct cctacggatt ccgcgatgct cacagatagc      360

cagagcgatg ccggagaaga cgggacagcc ccaggaacgc cttcagatct ccagtcggat      420

cctgaagaac tcgaagaagc cccagctgtc cgcgccgatc ctgacggagg ggcagcccca      480

gtcgccccag ccactcctgc cgagtccgag tctgaaggca gcagagatcc agccgccgag      540

ccagcctccg aggcagtccc tgccaccacg gccgagtctg cctccggggc agcccctgtc      600

acccaggtgg agcccgcagc cgcggcagtc tctgccaccc tggcggagcc tgccgcccgg      660

gcagccccta tcacccccaa ggagcccact acccgggcag tcccctctgc tagagcccat      720

ccggccgctg gagcagtccc tggcgcccca gcaatgtcag cctctgctag ggcagctgcc      780

gctagggcag cctatgcagg tccactggtc tggggagcca ggtcactctc agctactccc      840

gccgctcggg catcccttcc tgcccgcgca gcagctgccg cccgggcagc ctctgctgcc      900

cgcgcagtcg ctgctggccg gtcagcctct gccgccccca gcagggccca tcttagaccc      960

cccagccccg agatccaggt tgctgacccg cctactccgc ggcctcctcc gcggccgact     1020

gcctggcctg acaagtacga gcggggccga agctgctgca ggtacgaggc atcgtctggc     1080

atctgcgaga tcgagtcctc cagtgatgag tcggaagaag gggccaccgg ctgcttccag     1140

tggcttctgc ggcgaaaccg ccgccctggc ctgccccgga gccacacggt cgggagcaac     1200

ccagtccgca acttcttcac ccgagccttc ggaagctgct tcggtctatc cgagtgtacc     1260

cgatcacgat ccctcagccc cgggaaggcc aaggatccta tggaggagag gcgcaaacag     1320

atgcgcaaag aagccattga gatgcgagag cagaagcgcg cagataagaa acgcagcaag     1380

ctcatcgaca agcaactgga ggaggagaag atggactaca tgtgtacaca ccgcctgctg     1440

cttctag                                                               1447


<210>  27
<211>  689
<212>  PRT
<213>  Human

<400>  27

Met Gly Val Arg Asn Cys Leu Tyr Gly Asn Asn Met Ser Gly Gln Arg 
1               5                   10                  15      


Asp Ile Pro Pro Glu Ile Gly Glu Gln Pro Glu Gln Pro Pro Leu Glu 
            20                  25                  30          


Ala Pro Gly Ala Ala Ala Pro Gly Ala Gly Pro Ser Pro Ala Glu Glu 
        35                  40                  45              


Met Glu Thr Glu Pro Pro His Asn Glu Pro Ile Pro Val Glu Asn Asp 
    50                  55                  60                  


Gly Glu Ala Cys Gly Pro Pro Glu Val Ser Arg Pro Asn Phe Gln Val 
65                  70                  75                  80  


Leu Asn Pro Ala Phe Arg Glu Ala Gly Ala His Gly Ser Tyr Ser Pro 
                85                  90                  95      


Pro Pro Glu Glu Ala Met Pro Phe Glu Ala Glu Gln Pro Ser Leu Gly 
            100                 105                 110         


Gly Phe Trp Pro Thr Leu Glu Gln Pro Gly Phe Pro Ser Gly Val His 
        115                 120                 125             


Ala Gly Leu Glu Ala Phe Gly Pro Ala Leu Met Glu Pro Gly Ala Phe 
    130                 135                 140                 


Ser Gly Ala Arg Pro Gly Leu Gly Gly Tyr Ser Pro Pro Pro Glu Glu 
145                 150                 155                 160 


Ala Met Pro Phe Glu Phe Asp Gln Pro Ala Gln Arg Gly Cys Ser Gln 
                165                 170                 175     


Leu Leu Leu Gln Val Pro Asp Leu Ala Pro Gly Gly Pro Gly Ala Ala 
            180                 185                 190         


Gly Val Pro Gly Ala Pro Pro Glu Glu Pro Gln Ala Leu Arg Pro Ala 
        195                 200                 205             


Lys Ala Gly Ser Arg Gly Gly Tyr Ser Pro Pro Pro Glu Glu Thr Met 
    210                 215                 220                 


Pro Phe Glu Leu Asp Gly Glu Gly Phe Gly Asp Asp Ser Pro Pro Pro 
225                 230                 235                 240 


Gly Leu Ser Arg Val Ile Ala Gln Val Asp Gly Ser Ser Gln Phe Ala 
                245                 250                 255     


Ala Val Ala Ala Ser Ser Ala Val Arg Leu Thr Pro Ala Ala Asn Ala 
            260                 265                 270         


Pro Pro Leu Trp Val Pro Gly Ala Ile Gly Ser Pro Ser Gln Glu Ala 
        275                 280                 285             


Val Arg Pro Pro Ser Asn Phe Thr Gly Ser Ser Pro Trp Met Glu Ile 
    290                 295                 300                 


Ser Gly Pro Pro Phe Glu Ile Gly Ser Ala Pro Ala Gly Val Asp Asp 
305                 310                 315                 320 


Thr Pro Val Asn Met Asp Ser Pro Pro Ile Ala Leu Asp Gly Pro Pro 
                325                 330                 335     


Ile Lys Val Ser Gly Ala Pro Asp Lys Arg Glu Arg Ala Glu Arg Pro 
            340                 345                 350         


Pro Val Glu Glu Glu Ala Ala Glu Met Glu Gly Ala Ala Asp Ala Ala 
        355                 360                 365             


Glu Gly Gly Lys Val Pro Ser Pro Gly Tyr Gly Ser Pro Ala Ala Gly 
    370                 375                 380                 


Ala Ala Ser Ala Asp Thr Ala Ala Arg Ala Ala Pro Ala Ala Pro Ala 
385                 390                 395                 400 


Asp Pro Asp Ser Gly Ala Thr Pro Glu Asp Pro Asp Ser Gly Thr Ala 
                405                 410                 415     


Pro Ala Asp Pro Asp Ser Gly Ala Phe Ala Ala Asp Pro Asp Ser Gly 
            420                 425                 430         


Ala Ala Pro Ala Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp 
        435                 440                 445             


Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp Ala Pro Ala Asp 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Pro Glu Ala Pro Ala Ala Pro Ala Ala Ala 
465                 470                 475                 480 


Glu Thr Arg Ala Ala His Val Ala Pro Ala Ala Pro Asp Ala Gly Ala 
                485                 490                 495     


Pro Thr Ala Pro Ala Ala Ser Ala Thr Arg Ala Ala Gln Val Arg Arg 
            500                 505                 510         


Ala Ala Ser Ala Ala Pro Ala Ser Gly Ala Arg Arg Lys Ile His Leu 
        515                 520                 525             


Arg Pro Pro Ser Pro Glu Ile Gln Ala Ala Asp Pro Pro Thr Pro Arg 
    530                 535                 540                 


Pro Thr Arg Ala Ser Ala Trp Arg Gly Lys Ser Glu Ser Ser Arg Gly 
545                 550                 555                 560 


Arg Arg Val Tyr Tyr Asp Glu Gly Val Ala Ser Ser Asp Asp Asp Ser 
                565                 570                 575     


Ser Gly Asp Glu Ser Asp Asp Gly Thr Ser Gly Cys Leu Arg Trp Phe 
            580                 585                 590         


Gln His Arg Arg Asn Arg Arg Arg Arg Lys Pro Gln Arg Asn Leu Leu 
        595                 600                 605             


Arg Asn Phe Leu Val Gln Ala Phe Gly Gly Cys Phe Gly Arg Ser Glu 
    610                 615                 620                 


Ser Pro Gln Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro 
625                 630                 635                 640 


Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg 
                645                 650                 655     


Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln 
            660                 665                 670         


Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu 
        675                 680                 685             


Leu 
    


<210>  28
<211>  482
<212>  PRT
<213>  Murine

<400>  28

Met Glu Ile Thr Arg Pro Leu Leu Glu Ile Gly Arg Ala Ser Ile Gly 
1               5                   10                  15      


Val Asp Asp Asp Thr Ala Val Asn Met Asp Ser Pro Pro Ile Ala Ser 
            20                  25                  30          


Asp Gly Pro Pro Ile Glu Val Ser Gly Ala Pro Asp Lys Ser Glu Cys 
        35                  40                  45              


Ala Glu Arg Pro Pro Val Glu Arg Glu Ala Ala Glu Met Glu Gly Ser 
    50                  55                  60                  


Pro Thr Thr Ala Thr Ala Val Glu Gly Lys Val Pro Ser Pro Glu Arg 
65                  70                  75                  80  


Gly Asp Gly Ser Ser Thr Gln Pro Glu Ala Met Asp Ala Lys Pro Ala 
                85                  90                  95      


Pro Ala Ala Gln Ala Val Ser Thr Gly Ser Asp Ala Gly Ala Pro Thr 
            100                 105                 110         


Asp Ser Ala Met Leu Thr Asp Ser Gln Ser Asp Ala Gly Glu Asp Gly 
        115                 120                 125             


Thr Ala Pro Gly Thr Pro Ser Asp Leu Gln Ser Asp Pro Glu Glu Leu 
    130                 135                 140                 


Glu Glu Ala Pro Ala Val Arg Ala Asp Pro Asp Gly Gly Ala Ala Pro 
145                 150                 155                 160 


Val Ala Pro Ala Thr Pro Ala Glu Ser Glu Ser Glu Gly Ser Arg Asp 
                165                 170                 175     


Pro Ala Ala Glu Pro Ala Ser Glu Ala Val Pro Ala Thr Thr Ala Glu 
            180                 185                 190         


Ser Ala Ser Gly Ala Ala Pro Val Thr Gln Val Glu Pro Ala Ala Ala 
        195                 200                 205             


Ala Val Ser Ala Thr Leu Ala Glu Pro Ala Ala Arg Ala Ala Pro Ile 
    210                 215                 220                 


Thr Pro Lys Glu Pro Thr Thr Arg Ala Val Pro Ser Ala Arg Ala His 
225                 230                 235                 240 


Pro Ala Ala Gly Ala Val Pro Gly Ala Pro Ala Met Ser Ala Ser Ala 
                245                 250                 255     


Arg Ala Ala Ala Ala Arg Ala Ala Tyr Ala Gly Pro Leu Val Trp Gly 
            260                 265                 270         


Ala Arg Ser Leu Ser Ala Thr Pro Ala Ala Arg Ala Ser Leu Pro Ala 
        275                 280                 285             


Arg Ala Ala Ala Ala Ala Arg Ala Ala Ser Ala Ala Arg Ala Val Ala 
    290                 295                 300                 


Ala Gly Arg Ser Ala Ser Ala Ala Pro Ser Arg Ala His Leu Arg Pro 
305                 310                 315                 320 


Pro Ser Pro Glu Ile Gln Val Ala Asp Pro Pro Thr Pro Arg Pro Pro 
                325                 330                 335     


Pro Arg Pro Thr Ala Trp Pro Asp Lys Tyr Glu Arg Gly Arg Ser Cys 
            340                 345                 350         


Cys Arg Tyr Glu Ala Ser Ser Gly Ile Cys Glu Ile Glu Ser Ser Ser 
        355                 360                 365             


Asp Glu Ser Glu Glu Gly Ala Thr Gly Cys Phe Gln Trp Leu Leu Arg 
    370                 375                 380                 


Arg Asn Arg Arg Pro Gly Leu Pro Arg Ser His Thr Val Gly Ser Asn 
385                 390                 395                 400 


Pro Val Arg Asn Phe Phe Thr Arg Ala Phe Gly Ser Cys Phe Gly Leu 
                405                 410                 415     


Ser Glu Cys Thr Arg Ser Arg Ser Leu Ser Pro Gly Lys Ala Lys Asp 
            420                 425                 430         


Pro Met Glu Glu Arg Arg Lys Gln Met Arg Lys Glu Ala Ile Glu Met 
        435                 440                 445             


Arg Glu Gln Lys Arg Ala Asp Lys Lys Arg Ser Lys Leu Ile Asp Lys 
    450                 455                 460                 


Gln Leu Glu Glu Glu Lys Met Asp Tyr Met Cys Thr His Arg Leu Leu 
465                 470                 475                 480 


Leu Leu 
        


