                         LISTADO DE SECUENCIAS

<110>  Consejo Superior de Investigaciones Cientficas (CSIC)
       Fundacin para la Formacin e Investigacin Sanitarias de la Regin de Murcia.
 
<120>  Mtodo de obtencin de datos tiles para el diagnstico 
       diferencial de la enfermedad de Chagas, y para evaluar la 
       respuesta al tratamiento.

<130>  ES1641.406

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  92
<212>  PRT
<213>  Trypanosoma cruzi

<400>  1

Met Ala Thr Thr Leu Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp 
1               5                   10                  15      


Ala Glu Phe Ala Lys Lys Met Glu Glu Gln Asn Lys Lys Phe Phe Ala 
            20                  25                  30          


Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr 
        35                  40                  45              


Glu Lys Phe Glu Lys Met Ile Gln Glu His Thr Asp Lys Phe Asn Lys 
    50                  55                  60                  


Lys Met His Glu His Ser Glu His Phe Lys Ala Lys Phe Ala Glu Leu 
65                  70                  75                  80  


Leu Glu Gln Gln Lys Asn Ala Gln Phe Pro Gly Lys 
                85                  90          


<210>  2
<211>  680
<212>  PRT
<213>  Trypanosoma cruzi

<400>  2

Met Thr Tyr Glu Gly Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Trp Gln Asn Glu Arg Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Ser Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Arg 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Ser Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Lys Val Ile Thr 
                85                  90                  95      


Lys Gly Asp Asp Lys Pro Val Ile Gln Val Gln Phe Arg Gly Glu Thr 
            100                 105                 110         


Lys Thr Phe Asn Pro Glu Glu Val Ser Ser Met Val Leu Ser Lys Met 
        115                 120                 125             


Lys Glu Ile Ala Glu Ser Tyr Leu Gly Lys Gln Val Lys Lys Ala Val 
    130                 135                 140                 


Val Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Thr Ile Ala Gly Leu Glu Val Leu Arg Ile Ile Asn Glu 
                165                 170                 175     


Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Val Glu Asp Gly 
            180                 185                 190         


Lys Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Thr Leu Leu Thr Ile Asp Gly Gly Ile Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Ala His Phe Thr Asp Glu Phe Lys Arg Lys Asn Lys Gly Lys Asp Leu 
                245                 250                 255     


Ser Thr Asn Leu Arg Ala Leu Arg Arg Leu Arg Thr Ala Cys Glu Arg 
            260                 265                 270         


Ala Lys Arg Thr Leu Ser Ser Ala Ala Gln Ala Thr Ile Glu Ile Asp 
        275                 280                 285             


Ala Leu Phe Asp Asn Val Asp Phe Gln Ala Thr Ile Thr Arg Ala Arg 
    290                 295                 300                 


Phe Glu Glu Leu Cys Gly Glu Leu Phe Arg Gly Thr Leu Gln Pro Val 
305                 310                 315                 320 


Glu Arg Val Leu Gln Asp Ala Lys Met Asp Lys Arg Ala Val His Asp 
                325                 330                 335     


Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Met Gln Leu 
            340                 345                 350         


Val Ser Asp Phe Phe Arg Gly Lys Glu Leu Lys Lys Ser Ile Gln Pro 
        355                 360                 365             


Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Phe Ile Leu Thr 
    370                 375                 380                 


Gly Gly Lys Ser Lys Gln Thr Glu Gly Leu Leu Leu Leu Asp Val Thr 
385                 390                 395                 400 


Pro Leu Thr Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Ser Leu 
                405                 410                 415     


Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Lys Ser Gln Ile Phe Ser 
            420                 425                 430         


Thr Tyr Ala Asp Asn Gln Pro Gly Val His Ile Gln Val Phe Glu Gly 
        435                 440                 445             


Glu Arg Ala Met Thr Lys Asp Cys His Leu Leu Gly Thr Phe Glu Leu 
    450                 455                 460                 


Ser Gly Ile Pro Pro Pro Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
465                 470                 475                 480 


Phe Asp Leu Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Glu Glu Lys 
                485                 490                 495     


Gly Thr Gly Lys Arg Asn Gln Ile Val Leu Thr Asn Asp Lys Gly Arg 
            500                 505                 510         


Leu Ser Arg Ala Glu Ile Glu Arg Met Val Arg Glu Ala Ala Lys Tyr 
        515                 520                 525             


Glu Ala Glu Asp Lys Asp Gln Val Arg Gln Ile Asp Ala Lys Asn Gly 
    530                 535                 540                 


Leu Glu Asn Tyr Ala Phe Ser Met Lys Asn Ala Val Asn Asp Pro Asn 
545                 550                 555                 560 


Val Ala Gly Lys Ile Glu Glu Ala Asp Lys Lys Thr Ile Thr Ser Ala 
                565                 570                 575     


Val Glu Glu Ala Leu Glu Trp Leu Asn Asn Asn Gln Glu Ala Ser Lys 
            580                 585                 590         


Glu Glu Tyr Glu His Arg Gln Lys Glu Leu Glu Asn Leu Cys Thr Pro 
        595                 600                 605             


Ile Met Thr Asn Met Tyr Gln Gly Met Ala Gly Ala Gly Met Pro Gly 
    610                 615                 620                 


Gly Met Pro Gly Gly Met Pro Gly Gly Met Pro Gly Gly Met Pro Gly 
625                 630                 635                 640 


Gly Met Pro Gly Gly Met Pro Gly Gly Met Pro Gly Gly Met Pro Gly 
                645                 650                 655     


Gly Met Pro Gly Gly Met Pro Gly Gly Ala Asn Pro Ser Ser Ser Ser 
            660                 665                 670         


Gly Pro Glu Val Glu Glu Val Asp 
        675                 680 


<210>  3
<211>  600
<212>  PRT
<213>  Trypanosoma cruzi

<400>  3

Met Ser Tyr Lys Glu Ala Ser Gly Ala Val Gly Pro Ala Asp Gln Gln 
1               5                   10                  15      


Gln Pro Ala Val Pro Glu Val Thr Asp Val Thr Leu Glu Ala Ala Arg 
            20                  25                  30          


Lys Gln Lys Ile His Asn Leu Lys Leu Lys Thr Ser Cys Leu Ser Asn 
        35                  40                  45              


Glu Glu Phe Ile Gln Asp Leu His Val Ser Asp Trp Ser Glu Thr Gln 
    50                  55                  60                  


Lys Gln Lys Leu Leu Ala Ala His Glu Lys Ala Gln Glu Leu Leu Ser 
65                  70                  75                  80  


Ser Val Glu Gly Gly Thr Lys Trp Asn Leu Thr Glu Ala Tyr Asp Ile 
                85                  90                  95      


Lys Lys Leu Met Arg Val Cys Gly Leu Gln Leu Ser Val Arg Glu Leu 
            100                 105                 110         


Tyr Lys Pro Glu Asp Lys Pro His Phe Met Glu Val Val Ala Leu Lys 
        115                 120                 125             


Lys Thr Leu Asn Glu Leu Lys Gln His His Asn Lys Thr Arg Thr Val 
    130                 135                 140                 


Ser Phe Thr Gly Thr Ile Asp Asn Ala Ile Ala Lys Leu Glu Lys Ile 
145                 150                 155                 160 


Glu Asp Glu Leu Arg Arg Ser Gln Leu Asp Ala Ser Glu Met Ala Gln 
                165                 170                 175     


Val Pro Val Ala Val Leu Lys Asn Leu Glu Glu Cys Met Asn Val Thr 
            180                 185                 190         


Val Val Gln Thr Ala Leu Leu Gly Asn Glu Glu Gln Ile Lys Ala Gln 
        195                 200                 205             


Leu Ala Ala Ile Glu Lys Ala Lys Glu Ile Arg Asn Val Ala Ile Ala 
    210                 215                 220                 


Asp Gly Glu Met Ala Ile Ala Glu Glu Gln Tyr Tyr Ile Lys Ala Gln 
225                 230                 235                 240 


Leu Leu Glu His Leu Val Glu Leu Val Ala Asp Lys Phe Arg Ile Ile 
                245                 250                 255     


Gly Gln Thr Glu Asp Glu Asn Lys Pro Phe Gly Arg Ile Gln Asp Val 
            260                 265                 270         


Gln Lys Lys Ser Phe Gln Glu Thr Ser Ala Ile Lys Asp Ala Lys Arg 
        275                 280                 285             


Arg Leu Lys Gln Arg Cys Glu Asp Asp Leu Lys Asn Leu His Asp Ala 
    290                 295                 300                 


Ile Gln Lys Ala Asp Met Glu Asp Ala Glu Ala Met Lys Arg Phe Ala 
305                 310                 315                 320 


Thr Gln Lys Glu Lys Ser Glu Lys Phe Ile Gln Glu Asn Leu Asp Arg 
                325                 330                 335     


Gln Asp Glu Ala Trp Arg Arg Ile Gln Glu Leu Glu Arg Val Leu Gln 
            340                 345                 350         


Arg Leu Gly Thr Glu Arg Phe Glu Glu Val Lys Arg Arg Ile Glu Glu 
        355                 360                 365             


Asn Asp Arg Glu Glu Lys Arg Lys Val Glu Tyr Gln Gln Phe Leu Asp 
    370                 375                 380                 


Val Cys Gly Gln His Lys Lys Leu Leu Glu Leu Ser Val Tyr Asn Cys 
385                 390                 395                 400 


Asp Leu Ala Met Arg Cys Ile Gly Met Met Glu Glu Leu Val Ala Glu 
                405                 410                 415     


Gly Cys Ser Ala Ile Lys Ser Arg His Asp Lys Thr Asn Glu Glu Leu 
            420                 425                 430         


Gly Asp Leu Arg Leu Gln Val His Gln Glu Tyr Leu Glu Ala Phe Arg 
        435                 440                 445             


Arg Leu Tyr Lys Thr Leu Gly Gln Leu Val Tyr Lys Lys Glu Lys Arg 
    450                 455                 460                 


Leu Glu Glu Ile Asp Arg Asn Ile Arg Thr Thr His Ile Gln Leu Glu 
465                 470                 475                 480 


Phe Ala Ile Glu Thr Phe Asp Pro Asn Ala Lys Lys His Ser Asp Ala 
                485                 490                 495     


Lys Lys Glu Leu Tyr Lys Leu Arg Ala Gln Val Glu Glu Glu Leu Glu 
            500                 505                 510         


Met Leu Lys Asp Lys Met Ala Gln Ala Leu Glu Met Phe Gly Pro Thr 
        515                 520                 525             


Glu Asp Ala Leu Asn Gln Ala Gly Ile Glu Phe Val His Pro Ala Glu 
    530                 535                 540                 


Glu Val Glu Asp Gly Asn Leu Thr Arg Arg Ser Lys Met Val Glu Tyr 
545                 550                 555                 560 


Arg Ala His Leu Ala Lys Gln Glu Glu Val Lys Ile Ala Ala Glu Arg 
                565                 570                 575     


Glu Glu Leu Lys Arg Ser Lys Thr Leu Gln Ser Gln Gln Tyr Arg Gly 
            580                 585                 590         


Lys Thr Val Gln Gln Ile Thr Gln 
        595                 600 


<210>  4
<211>  218
<212>  PRT
<213>  Trypanosoma cruzi


<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Arg Gly Ser His His His His His His Gly Ser Ala Cys Glu Leu 
1               5                   10                  15      


Gly Thr Gly Thr Thr Cys Gln Val Phe Ser Asp Gly His Pro Ala Val 
            20                  25                  30          


Gly Val Ile Asn Ile Pro Ala Ala Asn Ile Ala Ser Arg Tyr Asp Gln 
        35                  40                  45              


Leu Val Thr Arg Val Val Thr His Glu Met Ala His Ala Leu Gly Phe 
    50                  55                  60                  


Ser Val Gly Phe Phe Glu Gly Ala Arg Ile Leu Glu Ser Ile Ser Asn 
65                  70                  75                  80  


Val Arg His Lys Asp Phe Asp Val Pro Val Ile Asn Ser Ser Thr Ala 
                85                  90                  95      


Val Ala Lys Ala Arg Glu Gln Tyr Gly Cys Asp Thr Leu Glu Tyr Leu 
            100                 105                 110         


Glu Ile Glu Asp Gln Gly Gly Ala Gly Ser Ala Gly Ser His Ile Lys 
        115                 120                 125             


Met Arg Asn Ala Gln Asp Glu Leu Met Ala Pro Ala Ala Ala Ala Gly 
    130                 135                 140                 


Tyr Tyr Ser Ala Leu Thr Met Ala Ile Phe Gln Asp Leu Gly Phe Tyr 
145                 150                 155                 160 


Gln Ala Asp Phe Ser Lys Ala Glu Val Met Pro Trp Gly Arg Gly Lys 
                165                 170                 175     


Leu Xaa Pro Ala Gly Gly Leu Pro Ser Gly Gly Ser Gln Cys Leu Arg 
            180                 185                 190         


Ala Cys His Ser Asp Ser Val Arg Gln Gln Arg Arg Phe Pro Gly Asp 
        195                 200                 205             


Thr Arg Cys Val Gly Thr Ala Gly Arg Gln 
    210                 215             


