                         SEQUENCE LISTING

<110>  Mayer, Gert
 
<120>  A method of diagnosing renal disorders

<130>  NB4/P

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  3396
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr 
            340                 345                 350         


Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser 
        355                 360                 365             


Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu 
    370                 375                 380                 


Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn 
385                 390                 395                 400 


Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr 
                405                 410                 415     


Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys 
            420                 425                 430         


Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly 
        435                 440                 445             


Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr 
    450                 455                 460                 


Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly 
                485                 490                 495     


Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu 
            500                 505                 510         


Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr 
    530                 535                 540                 


Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg 
545                 550                 555                 560 


Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile 
                565                 570                 575     


Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr 
            580                 585                 590         


His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro 
        595                 600                 605             


Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu 
    610                 615                 620                 


Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu 
625                 630                 635                 640 


Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe 
                645                 650                 655     


Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile 
            660                 665                 670         


Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu 
        675                 680                 685             


Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln 
    690                 695                 700                 


Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val 
705                 710                 715                 720 


Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val 
                725                 730                 735     


Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu 
            740                 745                 750         


Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu 
        755                 760                 765             


Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr 
    770                 775                 780                 


Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val 
785                 790                 795                 800 


Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu 
                805                 810                 815     


Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr 
            820                 825                 830         


Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu 
        835                 840                 845             


Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln 
    850                 855                 860                 


Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr 
865                 870                 875                 880 


Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr 
                885                 890                 895     


Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr 
            900                 905                 910         


Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val 
        915                 920                 925             


Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala 
    930                 935                 940                 


His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr 
945                 950                 955                 960 


Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser 
                965                 970                 975     


Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser 
            980                 985                 990         


Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp Ile Leu  Val Ile Asp 
        995                 1000                 1005             


Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro Glu Thr  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu Glu Phe  Pro Trp Lys 
    1025                 1030                 1035             


Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala Leu Ser  Ser Thr Ala 
    1040                 1045                 1050             


Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu Asp Glu  Gln Glu Gly 
    1055                 1060                 1065             


Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp Glu Leu  Leu Thr Gly 
    1070                 1075                 1080             


Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr Pro Val  Gly Lys Ile 
    1085                 1090                 1095             


Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala Val Thr  Glu His Lys 
    1100                 1105                 1110             


Val Lys  Thr Asp Glu Val Val  Thr Leu Thr Pro Arg  Ile Gly Pro 
    1115                 1120                 1125             


Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln Lys Tyr  Glu Thr Glu 
    1130                 1135                 1140             


Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser Leu Ser  Pro Phe Ser 
    1145                 1150                 1155             


Thr His  Ile Thr Gln Leu Met  Glu Glu Thr Thr Thr  Glu Lys Thr 
    1160                 1165                 1170             


Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly Leu Phe  Glu Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr Ile Lys  Val Thr Val 
    1190                 1195                 1200             


Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser Val Asp  Arg Leu His 
    1205                 1210                 1215             


Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala Ile Thr  Lys Lys Pro 
    1220                 1225                 1230             


Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu Thr Thr  Ser Asp Met 
    1235                 1240                 1245             


Val Ile  Ile Gly Glu Ser Thr  Ser His Val Pro Pro  Thr Thr Leu 
    1250                 1255                 1260             


Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr Asp Ile  Asp Arg Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr Gln Pro  Thr Arg Pro 
    1280                 1285                 1290             


Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly Pro Gln  Ala Leu Ser 
    1295                 1300                 1305             


Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe His Pro  Asp Ile Asn 
    1310                 1315                 1320             


Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys Thr Gly  Arg Met Ser 
    1325                 1330                 1335             


Asp Leu  Ser Val Ile Gly His  Pro Ile Asp Ser Glu  Ser Lys Glu 
    1340                 1345                 1350             


Asp Glu  Pro Cys Ser Glu Glu  Thr Asp Pro Val His  Asp Leu Met 
    1355                 1360                 1365             


Ala Glu  Ile Leu Pro Glu Phe  Pro Asp Ile Ile Glu  Ile Asp Leu 
    1370                 1375                 1380             


Tyr His  Ser Glu Glu Asn Glu  Glu Glu Glu Glu Glu  Cys Ala Asn 
    1385                 1390                 1395             


Ala Thr  Asp Val Thr Thr Thr  Pro Ser Val Gln Tyr  Ile Asn Gly 
    1400                 1405                 1410             


Lys His  Leu Val Thr Thr Val  Pro Lys Asp Pro Glu  Ala Ala Glu 
    1415                 1420                 1425             


Ala Arg  Arg Gly Gln Phe Glu  Ser Val Ala Pro Ser  Gln Asn Phe 
    1430                 1435                 1440             


Ser Asp  Ser Ser Glu Ser Asp  Thr His Pro Phe Val  Ile Ala Lys 
    1445                 1450                 1455             


Thr Glu  Leu Ser Thr Ala Val  Gln Pro Asn Glu Ser  Thr Glu Thr 
    1460                 1465                 1470             


Thr Glu  Ser Leu Glu Val Thr  Trp Lys Pro Glu Thr  Tyr Pro Glu 
    1475                 1480                 1485             


Thr Ser  Glu His Phe Ser Gly  Gly Glu Pro Asp Val  Phe Pro Thr 
    1490                 1495                 1500             


Val Pro  Phe His Glu Glu Phe  Glu Ser Gly Thr Ala  Lys Lys Gly 
    1505                 1510                 1515             


Ala Glu  Ser Val Thr Glu Arg  Asp Thr Glu Val Gly  His Gln Ala 
    1520                 1525                 1530             


His Glu  His Thr Glu Pro Val  Ser Leu Phe Pro Glu  Glu Ser Ser 
    1535                 1540                 1545             


Gly Glu  Ile Ala Ile Asp Gln  Glu Ser Gln Lys Ile  Ala Phe Ala 
    1550                 1555                 1560             


Arg Ala  Thr Glu Val Thr Phe  Gly Glu Glu Val Glu  Lys Ser Thr 
    1565                 1570                 1575             


Ser Val  Thr Tyr Thr Pro Thr  Ile Val Pro Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Tyr Val  Ser Glu Glu Glu Ala  Val Thr Leu Ile Gly  Asn Pro Trp 
    1595                 1600                 1605             


Pro Asp  Asp Leu Leu Ser Thr  Lys Glu Ser Trp Val  Glu Ala Thr 
    1610                 1615                 1620             


Pro Arg  Gln Val Val Glu Leu  Ser Gly Ser Ser Ser  Ile Pro Ile 
    1625                 1630                 1635             


Thr Glu  Gly Ser Gly Glu Ala  Glu Glu Asp Glu Asp  Thr Met Phe 
    1640                 1645                 1650             


Thr Met  Val Thr Asp Leu Ser  Gln Arg Asn Thr Thr  Asp Thr Leu 
    1655                 1660                 1665             


Ile Thr  Leu Asp Thr Ser Arg  Ile Ile Thr Glu Ser  Phe Phe Glu 
    1670                 1675                 1680             


Val Pro  Ala Thr Thr Ile Tyr  Pro Val Ser Glu Gln  Pro Ser Ala 
    1685                 1690                 1695             


Lys Val  Val Pro Thr Lys Phe  Val Ser Glu Thr Asp  Thr Ser Glu 
    1700                 1705                 1710             


Trp Ile  Ser Ser Thr Thr Val  Glu Glu Lys Lys Arg  Lys Glu Glu 
    1715                 1720                 1725             


Glu Gly  Thr Thr Gly Thr Ala  Ser Thr Phe Glu Val  Tyr Ser Ser 
    1730                 1735                 1740             


Thr Gln  Arg Ser Asp Gln Leu  Ile Leu Pro Phe Glu  Leu Glu Ser 
    1745                 1750                 1755             


Pro Asn  Val Ala Thr Ser Ser  Asp Ser Gly Thr Arg  Lys Ser Phe 
    1760                 1765                 1770             


Met Ser  Leu Thr Thr Pro Thr  Gln Ser Glu Arg Glu  Met Thr Asp 
    1775                 1780                 1785             


Ser Thr  Pro Val Phe Thr Glu  Thr Asn Thr Leu Glu  Asn Leu Gly 
    1790                 1795                 1800             


Ala Gln  Thr Thr Glu His Ser  Ser Ile His Gln Pro  Gly Val Gln 
    1805                 1810                 1815             


Glu Gly  Leu Thr Thr Leu Pro  Arg Ser Pro Ala Ser  Val Phe Met 
    1820                 1825                 1830             


Glu Gln  Gly Ser Gly Glu Ala  Ala Ala Asp Pro Glu  Thr Thr Thr 
    1835                 1840                 1845             


Val Ser  Ser Phe Ser Leu Asn  Val Glu Tyr Ala Ile  Gln Ala Glu 
    1850                 1855                 1860             


Lys Glu  Val Ala Gly Thr Leu  Ser Pro His Val Glu  Thr Thr Phe 
    1865                 1870                 1875             


Ser Thr  Glu Pro Thr Gly Leu  Val Leu Ser Thr Val  Met Asp Arg 
    1880                 1885                 1890             


Val Val  Ala Glu Asn Ile Thr  Gln Thr Ser Arg Glu  Ile Val Ile 
    1895                 1900                 1905             


Ser Glu  Arg Leu Gly Glu Pro  Asn Tyr Gly Ala Glu  Ile Arg Gly 
    1910                 1915                 1920             


Phe Ser  Thr Gly Phe Pro Leu  Glu Glu Asp Phe Ser  Gly Asp Phe 
    1925                 1930                 1935             


Arg Glu  Tyr Ser Thr Val Ser  His Pro Ile Ala Lys  Glu Glu Thr 
    1940                 1945                 1950             


Val Met  Met Glu Gly Ser Gly  Asp Ala Ala Phe Arg  Asp Thr Gln 
    1955                 1960                 1965             


Thr Ser  Pro Ser Thr Val Pro  Thr Ser Val His Ile  Ser His Ile 
    1970                 1975                 1980             


Ser Asp  Ser Glu Gly Pro Ser  Ser Thr Met Val Ser  Thr Ser Ala 
    1985                 1990                 1995             


Phe Pro  Trp Glu Glu Phe Thr  Ser Ser Ala Glu Gly  Ser Gly Glu 
    2000                 2005                 2010             


Gln Leu  Val Thr Val Ser Ser  Ser Val Val Pro Val  Leu Pro Ser 
    2015                 2020                 2025             


Ala Val  Gln Lys Phe Ser Gly  Thr Ala Ser Ser Ile  Ile Asp Glu 
    2030                 2035                 2040             


Gly Leu  Gly Glu Val Gly Thr  Val Asn Glu Ile Asp  Arg Arg Ser 
    2045                 2050                 2055             


Thr Ile  Leu Pro Thr Ala Glu  Val Glu Gly Thr Lys  Ala Pro Val 
    2060                 2065                 2070             


Glu Lys  Glu Glu Val Lys Val  Ser Gly Thr Val Ser  Thr Asn Phe 
    2075                 2080                 2085             


Pro Gln  Thr Ile Glu Pro Ala  Lys Leu Trp Ser Arg  Gln Glu Val 
    2090                 2095                 2100             


Asn Pro  Val Arg Gln Glu Ile  Glu Ser Glu Thr Thr  Ser Glu Glu 
    2105                 2110                 2115             


Gln Ile  Gln Glu Glu Lys Ser  Phe Glu Ser Pro Gln  Asn Ser Pro 
    2120                 2125                 2130             


Ala Thr  Glu Gln Thr Ile Phe  Asp Ser Gln Thr Phe  Thr Glu Thr 
    2135                 2140                 2145             


Glu Leu  Lys Thr Thr Asp Tyr  Ser Val Leu Thr Thr  Lys Lys Thr 
    2150                 2155                 2160             


Tyr Ser  Asp Asp Lys Glu Met  Lys Glu Glu Asp Thr  Ser Leu Val 
    2165                 2170                 2175             


Asn Met  Ser Thr Pro Asp Pro  Asp Ala Asn Gly Leu  Glu Ser Tyr 
    2180                 2185                 2190             


Thr Thr  Leu Pro Glu Ala Thr  Glu Lys Ser His Phe  Phe Leu Ala 
    2195                 2200                 2205             


Thr Ala  Leu Val Thr Glu Ser  Ile Pro Ala Glu His  Val Val Thr 
    2210                 2215                 2220             


Asp Ser  Pro Ile Lys Lys Glu  Glu Ser Thr Lys His  Phe Pro Lys 
    2225                 2230                 2235             


Gly Met  Arg Pro Thr Ile Gln  Glu Ser Asp Thr Glu  Leu Leu Phe 
    2240                 2245                 2250             


Ser Gly  Leu Gly Ser Gly Glu  Glu Val Leu Pro Thr  Leu Pro Thr 
    2255                 2260                 2265             


Glu Ser  Val Asn Phe Thr Glu  Val Glu Gln Ile Asn  Asn Thr Leu 
    2270                 2275                 2280             


Tyr Pro  His Thr Ser Gln Val  Glu Ser Thr Ser Ser  Asp Lys Ile 
    2285                 2290                 2295             


Glu Asp  Phe Asn Arg Met Glu  Asn Val Ala Lys Glu  Val Gly Pro 
    2300                 2305                 2310             


Leu Val  Ser Gln Thr Asp Ile  Phe Glu Gly Ser Gly  Ser Val Thr 
    2315                 2320                 2325             


Ser Thr  Thr Leu Ile Glu Ile  Leu Ser Asp Thr Gly  Ala Glu Gly 
    2330                 2335                 2340             


Pro Thr  Val Ala Pro Leu Pro  Phe Ser Thr Asp Ile  Gly His Pro 
    2345                 2350                 2355             


Gln Asn  Gln Thr Val Arg Trp  Ala Glu Glu Ile Gln  Thr Ser Arg 
    2360                 2365                 2370             


Pro Gln  Thr Ile Thr Glu Gln  Asp Ser Asn Lys Asn  Ser Ser Thr 
    2375                 2380                 2385             


Ala Glu  Ile Asn Glu Thr Thr  Thr Ser Ser Thr Asp  Phe Leu Ala 
    2390                 2395                 2400             


Arg Ala  Tyr Gly Phe Glu Met  Ala Lys Glu Phe Val  Thr Ser Ala 
    2405                 2410                 2415             


Pro Lys  Pro Ser Asp Leu Tyr  Tyr Glu Pro Ser Gly  Glu Gly Ser 
    2420                 2425                 2430             


Gly Glu  Val Asp Ile Val Asp  Ser Phe His Thr Ser  Ala Thr Thr 
    2435                 2440                 2445             


Gln Ala  Thr Arg Gln Glu Ser  Ser Thr Thr Phe Val  Ser Asp Gly 
    2450                 2455                 2460             


Ser Leu  Glu Lys His Pro Glu  Val Pro Ser Ala Lys  Ala Val Thr 
    2465                 2470                 2475             


Ala Asp  Gly Phe Pro Thr Val  Ser Val Met Leu Pro  Leu His Ser 
    2480                 2485                 2490             


Glu Gln  Asn Lys Ser Ser Pro  Asp Pro Thr Ser Thr  Leu Ser Asn 
    2495                 2500                 2505             


Thr Val  Ser Tyr Glu Arg Ser  Thr Asp Gly Ser Phe  Gln Asp Arg 
    2510                 2515                 2520             


Phe Arg  Glu Phe Glu Asp Ser  Thr Leu Lys Pro Asn  Arg Lys Lys 
    2525                 2530                 2535             


Pro Thr  Glu Asn Ile Ile Ile  Asp Leu Asp Lys Glu  Asp Lys Asp 
    2540                 2545                 2550             


Leu Ile  Leu Thr Ile Thr Glu  Ser Thr Ile Leu Glu  Ile Leu Pro 
    2555                 2560                 2565             


Glu Leu  Thr Ser Asp Lys Asn  Thr Ile Ile Asp Ile  Asp His Thr 
    2570                 2575                 2580             


Lys Pro  Val Tyr Glu Asp Ile  Leu Gly Met Gln Thr  Asp Ile Asp 
    2585                 2590                 2595             


Thr Glu  Val Pro Ser Glu Pro  His Asp Ser Asn Asp  Glu Ser Asn 
    2600                 2605                 2610             


Asp Asp  Ser Thr Gln Val Gln  Glu Ile Tyr Glu Ala  Ala Val Asn 
    2615                 2620                 2625             


Leu Ser  Leu Thr Glu Glu Thr  Phe Glu Gly Ser Ala  Asp Val Leu 
    2630                 2635                 2640             


Ala Ser  Tyr Thr Gln Ala Thr  His Asp Glu Ser Met  Thr Tyr Glu 
    2645                 2650                 2655             


Asp Arg  Ser Gln Leu Asp His  Met Gly Phe His Phe  Thr Thr Gly 
    2660                 2665                 2670             


Ile Pro  Ala Pro Ser Thr Glu  Thr Glu Leu Asp Val  Leu Leu Pro 
    2675                 2680                 2685             


Thr Ala  Thr Ser Leu Pro Ile  Pro Arg Lys Ser Ala  Thr Val Ile 
    2690                 2695                 2700             


Pro Glu  Ile Glu Gly Ile Lys  Ala Glu Ala Lys Ala  Leu Asp Asp 
    2705                 2710                 2715             


Met Phe  Glu Ser Ser Thr Leu  Ser Asp Gly Gln Ala  Ile Ala Asp 
    2720                 2725                 2730             


Gln Ser  Glu Ile Ile Pro Thr  Leu Gly Gln Phe Glu  Arg Thr Gln 
    2735                 2740                 2745             


Glu Glu  Tyr Glu Asp Lys Lys  His Ala Gly Pro Ser  Phe Gln Pro 
    2750                 2755                 2760             


Glu Phe  Ser Ser Gly Ala Glu  Glu Ala Leu Val Asp  His Thr Pro 
    2765                 2770                 2775             


Tyr Leu  Ser Ile Ala Thr Thr  His Leu Met Asp Gln  Ser Val Thr 
    2780                 2785                 2790             


Glu Val  Pro Asp Val Met Glu  Gly Ser Asn Pro Pro  Tyr Tyr Thr 
    2795                 2800                 2805             


Asp Thr  Thr Leu Ala Val Ser  Thr Phe Ala Lys Leu  Ser Ser Gln 
    2810                 2815                 2820             


Thr Pro  Ser Ser Pro Leu Thr  Ile Tyr Ser Gly Ser  Glu Ala Ser 
    2825                 2830                 2835             


Gly His  Thr Glu Ile Pro Gln  Pro Ser Ala Leu Pro  Gly Ile Asp 
    2840                 2845                 2850             


Val Gly  Ser Ser Val Met Ser  Pro Gln Asp Ser Phe  Lys Glu Ile 
    2855                 2860                 2865             


His Val  Asn Ile Glu Ala Thr  Phe Lys Pro Ser Ser  Glu Glu Tyr 
    2870                 2875                 2880             


Leu His  Ile Thr Glu Pro Pro  Ser Leu Ser Pro Asp  Thr Lys Leu 
    2885                 2890                 2895             


Glu Pro  Ser Glu Asp Asp Gly  Lys Pro Glu Leu Leu  Glu Glu Met 
    2900                 2905                 2910             


Glu Ala  Ser Pro Thr Glu Leu  Ile Ala Val Glu Gly  Thr Glu Ile 
    2915                 2920                 2925             


Leu Gln  Asp Phe Gln Asn Lys  Thr Asp Gly Gln Val  Ser Gly Glu 
    2930                 2935                 2940             


Ala Ile  Lys Met Phe Pro Thr  Ile Lys Thr Pro Glu  Ala Gly Thr 
    2945                 2950                 2955             


Val Ile  Thr Thr Ala Asp Glu  Ile Glu Leu Glu Gly  Ala Thr Gln 
    2960                 2965                 2970             


Trp Pro  His Ser Thr Ser Ala  Ser Ala Thr Tyr Gly  Val Glu Ala 
    2975                 2980                 2985             


Gly Val  Val Pro Trp Leu Ser  Pro Gln Thr Ser Glu  Arg Pro Thr 
    2990                 2995                 3000             


Leu Ser  Ser Ser Pro Glu Ile  Asn Pro Glu Thr Gln  Ala Ala Leu 
    3005                 3010                 3015             


Ile Arg  Gly Gln Asp Ser Thr  Ile Ala Ala Ser Glu  Gln Gln Val 
    3020                 3025                 3030             


Ala Ala  Arg Ile Leu Asp Ser  Asn Asp Gln Ala Thr  Val Asn Pro 
    3035                 3040                 3045             


Val Glu  Phe Asn Thr Glu Val  Ala Thr Pro Pro Phe  Ser Leu Leu 
    3050                 3055                 3060             


Glu Thr  Ser Asn Glu Thr Asp  Phe Leu Ile Gly Ile  Asn Glu Glu 
    3065                 3070                 3075             


Ser Val  Glu Gly Thr Ala Ile  Tyr Leu Pro Gly Pro  Asp Arg Cys 
    3080                 3085                 3090             


Lys Met  Asn Pro Cys Leu Asn  Gly Gly Thr Cys Tyr  Pro Thr Glu 
    3095                 3100                 3105             


Thr Ser  Tyr Val Cys Thr Cys  Val Pro Gly Tyr Ser  Gly Asp Gln 
    3110                 3115                 3120             


Cys Glu  Leu Asp Phe Asp Glu  Cys His Ser Asn Pro  Cys Arg Asn 
    3125                 3130                 3135             


Gly Ala  Thr Cys Val Asp Gly  Phe Asn Thr Phe Arg  Cys Leu Cys 
    3140                 3145                 3150             


Leu Pro  Ser Tyr Val Gly Ala  Leu Cys Glu Gln Asp  Thr Glu Thr 
    3155                 3160                 3165             


Cys Asp  Tyr Gly Trp His Lys  Phe Gln Gly Gln Cys  Tyr Lys Tyr 
    3170                 3175                 3180             


Phe Ala  His Arg Arg Thr Trp  Asp Ala Ala Glu Arg  Glu Cys Arg 
    3185                 3190                 3195             


Leu Gln  Gly Ala His Leu Thr  Ser Ile Leu Ser His  Glu Glu Gln 
    3200                 3205                 3210             


Met Phe  Val Asn Arg Val Gly  His Asp Tyr Gln Trp  Ile Gly Leu 
    3215                 3220                 3225             


Asn Asp  Lys Met Phe Glu His  Asp Phe Arg Trp Thr  Asp Gly Ser 
    3230                 3235                 3240             


Thr Leu  Gln Tyr Glu Asn Trp  Arg Pro Asn Gln Pro  Asp Ser Phe 
    3245                 3250                 3255             


Phe Ser  Ala Gly Glu Asp Cys  Val Val Ile Ile Trp  His Glu Asn 
    3260                 3265                 3270             


Gly Gln  Trp Asn Asp Val Pro  Cys Asn Tyr His Leu  Thr Tyr Thr 
    3275                 3280                 3285             


Cys Lys  Lys Gly Thr Val Ala  Cys Gly Gln Pro Pro  Val Val Glu 
    3290                 3295                 3300             


Asn Ala  Lys Thr Phe Gly Lys  Met Lys Pro Arg Tyr  Glu Ile Asn 
    3305                 3310                 3315             


Ser Leu  Ile Arg Tyr His Cys  Lys Asp Gly Phe Ile  Gln Arg His 
    3320                 3325                 3330             


Leu Pro  Thr Ile Arg Cys Leu  Gly Asn Gly Arg Trp  Ala Ile Pro 
    3335                 3340                 3345             


Lys Ile  Thr Cys Met Asn Pro  Ser Ala Tyr Gln Arg  Thr Tyr Ser 
    3350                 3355                 3360             


Met Lys  Tyr Phe Lys Asn Ser  Ser Ser Ala Lys Asp  Asn Ser Ile 
    3365                 3370                 3375             


Asn Thr  Ser Lys His Asp His  Arg Trp Ser Arg Arg  Trp Gln Glu 
    3380                 3385                 3390             


Ser Arg  Arg 
    3395     


<210>  2
<211>  12057
<212>  DNA
<213>  Homo sapiens

<400>  2
acagtgatat aatgatgatg ggtgtcacaa cccgcatttg aacttgcagg cgagctgccc     60

cgagcctttc tggggaagaa ctccaggcgt gcggacgcaa cagccgagaa cattaggtgt    120

tgtggacagg agctgggacc aagatcttcg gccagccccg catcctcccg catcttccag    180

caccgtcccg caccctccgc atccttcccc gggccaccac gcttcctatg tgacccgcct    240

gggcaacgcc gaacccagtc gcgcagcgct gcagtgaatt ttccccccaa actgcaataa    300

gccgccttcc aaggccaaga tgttcataaa tataaagagc atcttatgga tgtgttcaac    360

cttaatagta acccatgcgc tacataaagt caaagtggga aaaagcccac cggtgagggg    420

ctccctctct ggaaaagtca gcctaccttg tcatttttca acgatgccta ctttgccacc    480

cagttacaac accagtgaat ttctccgcat caaatggtct aagattgaag tggacaaaaa    540

tggaaaagat ttgaaagaga ctactgtcct tgtggcccaa aatggaaata tcaagattgg    600

tcaggactac aaagggagag tgtctgtgcc cacacatccc gaggctgtgg gcgatgcctc    660

cctcactgtg gtcaagctgc tggcaagtga tgcgggtctt taccgctgtg acgtcatgta    720

cgggattgaa gacacacaag acacggtgtc actgactgtg gatggggttg tgtttcacta    780

cagggcggca accagcaggt acacactgaa ttttgaggct gctcagaagg cttgtttgga    840

cgttggggca gtcatagcaa ctccagagca gctctttgct gcctatgaag atggatttga    900

gcagtgtgac gcaggctggc tggctgatca gactgtcaga tatcccatcc gggctcccag    960

agtaggctgt tatggagata agatgggaaa ggcaggagtc aggacttatg gattccgttc   1020

tccccaggaa acttacgatg tgtattgtta tgtggatcat ctggatggtg atgtgttcca   1080

cctcactgtc cccagtaaat tcaccttcga ggaggctgca aaagagtgtg aaaaccagga   1140

tgccaggctg gcaacagtgg gggaactcca ggcggcatgg aggaacggct ttgaccagtg   1200

cgattacggg tggctgtcgg atgccagcgt gcgccaccct gtgactgtgg ccagggccca   1260

gtgtggaggt ggtctacttg gggtgagaac cctgtatcgt tttgagaacc agacaggctt   1320

ccctccccct gatagcagat ttgatgccta ctgctttaaa cctaaagagg ctacaaccat   1380

cgatttgagt atcctcgcag aaactgcatc acccagttta tccaaagaac cacaaatggt   1440

ttctgataga actacaccaa tcatcccttt agttgatgaa ttacctgtca ttccaacaga   1500

gttccctccc gtgggaaata ttgtcagttt tgaacagaaa gccacagtcc aacctcaggc   1560

tatcacagat agtttagcca ccaaattacc cacacctact ggcagtacca agaagccctg   1620

ggatatggat gactactcac cttctgcttc aggacctctt ggaaagctag acatatcaga   1680

aattaaggaa gaagtgctcc agagtacaac tggcgtctct cattatgcta cggattcatg   1740

ggatggtgtc gtggaagata aacaaacaca agaatcggtt acacagattg aacaaataga   1800

agtgggtcct ttggtaacat ctatggaaat cttaaagcac attccttcca aggaattccc   1860

tgtaactgaa acaccattgg taactgcaag aatgatcctg gaatccaaaa ctgaaaagaa   1920

aatggtaagc actgtttctg aattggtaac cacaggtcac tatggattca ccttgggaga   1980

agaggatgat gaagacagaa cacttacagt tggatctgat gagagcacct tgatctttga   2040

ccaaattcct gaagtcatta cggtgtcaaa gacttcagaa gacaccatcc acactcattt   2100

agaagacttg gagtcagtct cagcatccac aactgtttcc cctttaatta tgcctgataa   2160

taatggatca tccatggatg actgggaaga gagacaaact agtggtagga taacggaaga   2220

gtttcttggc aaatatctgt ctactacacc ttttccatca cagcatcgta cagaaataga   2280

attgtttcct tattctggtg ataaaatatt agtagaggga atttccacag ttatttatcc   2340

ttctctacaa acagaaatga cacatagaag agaaagaaca gaaacactaa taccagagat   2400

gagaacagat acttatacag atgaaataca agaagagatc actaaaagtc catttatggg   2460

aaaaacagaa gaagaagtct tctctgggat gaaactctct acatctctct cagagccaat   2520

tcatgttaca gagtcttctg tggaaatgac caagtctttt gatttcccaa cattgataac   2580

aaagttaagt gcagagccaa cagaagtaag agatatggag gaagacttta cagcaactcc   2640

aggtactaca aaatatgatg aaaatattac aacagtgctt ttggcccatg gtactttaag   2700

tgttgaagca gccactgtat caaaatggtc atgggatgaa gataatacaa catccaagcc   2760

tttagagtct acagaacctt cagcctcttc aaaattgccc cctgccttac tcacaactgt   2820

ggggatgaat ggaaaggata aagacatccc aagtttcact gaagatggag cagatgaatt   2880

tactcttatt ccagatagta ctcaaaagca gttagaggag gttactgatg aagacatagc   2940

agcccatgga aaattcacaa ttagatttca gccaactaca tcaactggta ttgcagaaaa   3000

gtcaactttg agagattcta caactgaaga aaaagttcca cctatcacaa gcactgaagg   3060

ccaagtttat gcaaccatgg aaggaagtgc tttgggtgaa gtagaagatg tggacctctc   3120

taagccagta tctactgttc cccaatttgc acacacttca gaggtggaag gattagcatt   3180

tgttagttat agtagcaccc aagagcctac tacttatgta gactcttccc ataccattcc   3240

tctttctgta attcccaaga cagactgggg agtgttagta ccttctgttc catcagaaga   3300

tgaagttcta ggtgaaccct ctcaagacat acttgtcatt gatcagactc gccttgaagc   3360

gactatttct ccagaaacta tgagaacaac aaaaatcaca gagggaacaa ctcaggaaga   3420

attcccttgg aaagaacaga ctgcagagaa accagttcct gctctcagtt ctacagcttg   3480

gactcccaag gaggcagtaa caccactgga tgaacaagag ggcgatggat cagcatatac   3540

agtctctgaa gatgaattgt tgacaggttc tgagagggtc ccagttttag aaacaactcc   3600

agttggaaaa attgatcaca gtgtgtctta tccaccaggt gctgtaactg agcacaaagt   3660

gaaaacagat gaagtggtaa cactaacacc acgcattggg ccaaaagtat ctttaagtcc   3720

agggcctgaa caaaaatatg aaacagaagg tagtagtaca acaggattta catcatcttt   3780

gagtcctttt agtacccaca ttacccagct tatggaagaa accactactg agaaaacatc   3840

cctagaggat attgatttag gctcaggatt atttgaaaag cccaaagcca cagaactcat   3900

agaattttca acaatcaaag tcacagttcc aagtgatatt accactgcct tcagttcagt   3960

agacagactt cacacaactt cagcattcaa gccatcttcc gcgatcacta agaaaccacc   4020

tctcatcgac agggaacctg gtgaagaaac aaccagtgac atggtaatca ttggagaatc   4080

aacatctcat gttcctccca ctacccttga agatattgta gccaaggaaa cagaaaccga   4140

tattgataga gagtatttca cgacttcaag tcctcctgct acacagccaa caagaccacc   4200

cactgtggaa gacaaagagg cctttggacc tcaggcgctt tctacgccac agcccccagc   4260

aagcacaaaa tttcaccctg acattaatgt ttatattatt gaggtcagag aaaataagac   4320

aggtcgaatg agtgatttga gtgtaattgg tcatccaata gattcagaat ctaaagaaga   4380

tgaaccttgt agtgaagaaa cagatccagt gcatgatcta atggctgaaa ttttacctga   4440

attccctgac ataattgaaa tagacctata ccacagtgaa gaaaatgaag aagaagaaga   4500

agagtgtgca aatgctactg atgtgacaac caccccatct gtgcagtaca taaatgggaa   4560

gcatctcgtt accactgtgc ccaaggaccc agaagctgca gaagctaggc gtggccagtt   4620

tgaaagtgtt gcaccttctc agaatttctc ggacagctct gaaagtgata ctcatccatt   4680

tgtaatagcc aaaacggaat tgtctactgc tgtgcaacct aatgaatcta cagaaacaac   4740

tgagtctctt gaagttacat ggaagcctga gacttaccct gaaacatcag aacatttttc   4800

aggtggtgag cctgatgttt tccccacagt cccattccat gaggaatttg aaagtggaac   4860

agccaaaaaa ggggcagaat cagtcacaga gagagatact gaagttggtc atcaggcaca   4920

tgaacatact gaacctgtat ctctgtttcc tgaagagtct tcaggagaga ttgccattga   4980

ccaagaatct cagaaaatag cctttgcaag ggctacagaa gtaacatttg gtgaagaggt   5040

agaaaaaagt acttctgtca catacactcc cactatagtt ccaagttctg catcagcata   5100

tgtttcagag gaagaagcag ttaccctaat aggaaatcct tggccagatg acctgttgtc   5160

taccaaagaa agctgggtag aagcaactcc tagacaagtt gtagagctct cagggagttc   5220

ttcgattcca attacagaag gctctggaga agcagaagaa gatgaagata caatgttcac   5280

catggtaact gatttatcac agagaaatac tactgataca ctcattactt tagacactag   5340

caggataatc acagaaagct tttttgaggt tcctgcaacc accatttatc cagtttctga   5400

acaaccttct gcaaaagtgg tgcctaccaa gtttgtaagt gaaacagaca cttctgagtg   5460

gatttccagt accactgttg aggaaaagaa aaggaaggag gaggagggaa ctacaggtac   5520

ggcttctaca tttgaggtat attcatctac acagagatcg gatcaattaa ttttaccctt   5580

tgaattagaa agtccaaatg tagctacatc tagtgattca ggtaccagga aaagttttat   5640

gtccttgaca acaccaacac agtctgaaag ggaaatgaca gattctactc ctgtctttac   5700

agaaacaaat acattagaaa atttgggggc acagaccact gagcacagca gtatccatca   5760

acctggggtt caggaagggc tgaccactct cccacgtagt cctgcctctg tctttatgga   5820

gcagggctct ggagaagctg ctgccgaccc agaaaccacc actgtttctt cattttcatt   5880

aaacgtagag tatgcaattc aagccgaaaa ggaagtagct ggcactttgt ctccgcatgt   5940

ggaaactaca ttctccactg agccaacagg actggttttg agtacagtaa tggacagagt   6000

agttgctgaa aatataaccc aaacatccag ggaaatagtg atttcagagc gattaggaga   6060

accaaattat ggggcagaaa taaggggctt ttccacaggt tttcctttgg aggaagattt   6120

cagtggtgac tttagagaat actcaacagt gtctcatccc atagcaaaag aagaaacggt   6180

aatgatggaa ggctctggag atgcagcatt tagggacacc cagacttcac catctacagt   6240

acctacttca gttcacatca gtcacatatc tgactcagaa ggacccagta gcaccatggt   6300

cagcacttca gccttcccct gggaagagtt tacatcctca gctgagggct caggtgagca   6360

actggtcaca gtcagcagct ctgttgttcc agtgcttccc agtgctgtgc aaaagttttc   6420

tggtacagct tcctccatta tcgacgaagg attgggagaa gtgggtactg tcaatgaaat   6480

tgatagaaga tccaccattt taccaacagc agaagtggaa ggtacgaaag ctccagtaga   6540

gaaggaggaa gtaaaggtca gtggcacagt ttcaacaaac tttccccaaa ctatagagcc   6600

agccaaatta tggtctaggc aagaagtcaa ccctgtaaga caagaaattg aaagtgaaac   6660

aacatcagag gaacaaattc aagaagaaaa gtcatttgaa tcccctcaaa actctcctgc   6720

aacagaacaa acaatctttg attcacagac atttactgaa actgaactca aaaccacaga   6780

ttattctgta ctaacaacaa agaaaactta cagtgatgat aaagaaatga aggaggaaga   6840

cacttcttta gttaacatgt ctactccaga tccagatgca aatggcttgg aatcttacac   6900

aactctccct gaagctactg aaaagtcaca ttttttctta gctactgcat tagtaactga   6960

atctatacca gctgaacatg tagtcacaga ttcaccaatc aaaaaggaag aaagtacaaa   7020

acattttccg aaaggcatga gaccaacaat tcaagagtca gatactgagc tcttattctc   7080

tggactggga tcaggagaag aagttttacc tactctacca acagagtcag tgaattttac   7140

tgaagtggaa caaatcaata acacattata tccccacact tctcaagtgg aaagtacctc   7200

aagtgacaaa attgaagact ttaacagaat ggaaaatgtg gcaaaagaag ttggaccact   7260

cgtatctcaa acagacatct ttgaaggtag tgggtcagta accagcacaa cattaataga   7320

aattttaagt gacactggag cagaaggacc cacggtggca cctctccctt tctccacgga   7380

catcggacat cctcaaaatc agactgtcag gtgggcagaa gaaatccaga ctagtagacc   7440

acaaaccata actgaacaag actctaacaa gaattcttca acagcagaaa ttaacgaaac   7500

aacaacctca tctactgatt ttctggctag agcttatggt tttgaaatgg ccaaagaatt   7560

tgttacatca gcaccaaaac catctgactt gtattatgaa ccttctggag aaggatctgg   7620

agaagtggat attgttgatt catttcacac ttctgcaact actcaggcaa ccagacaaga   7680

aagcagcacc acatttgttt ctgatgggtc cctggaaaaa catcctgagg tgccaagcgc   7740

taaagctgtt actgctgatg gattcccaac agtttcagtg atgctgcctc ttcattcaga   7800

gcagaacaaa agctcccctg atccaactag cacactgtca aatacagtgt catatgagag   7860

gtccacagac ggtagtttcc aagaccgttt cagggaattc gaggattcca ccttaaaacc   7920

taacagaaaa aaacccactg aaaatattat catagacctg gacaaagagg acaaggattt   7980

aatattgaca attacagaga gtaccatcct tgaaattcta cctgagctga catcggataa   8040

aaatactatc atagatattg atcatactaa acctgtgtat gaagacattc ttggaatgca   8100

aacagatata gatacagagg taccatcaga accacatgac agtaatgatg aaagtaatga   8160

tgacagcact caagttcaag agatctatga ggcagctgtc aacctttctt taactgagga   8220

aacatttgag ggctctgctg atgttctggc tagctacact caggcaacac atgatgaatc   8280

aatgacttat gaagatagaa gccaactaga tcacatgggc tttcacttca caactgggat   8340

ccctgctcct agcacagaaa cagaattaga cgttttactt cccacggcaa catccctgcc   8400

aattcctcgt aagtctgcca cagttattcc agagattgaa ggaataaaag ctgaagcaaa   8460

agccctggat gacatgtttg aatcaagcac tttgtctgat ggtcaagcta ttgcagacca   8520

aagtgaaata ataccaacat tgggccaatt tgaaaggact caggaggagt atgaagacaa   8580

aaaacatgct ggtccttctt ttcagccaga attctcttca ggagctgagg aggcattagt   8640

agaccatact ccctatctaa gtattgctac tacccacctt atggatcaga gtgtaacaga   8700

ggtgcctgat gtgatggaag gatccaatcc cccatattac actgatacaa cattagcagt   8760

ttcaacattt gcgaagttgt cttctcagac accatcatct cccctcacta tctactcagg   8820

cagtgaagcc tctggacaca cagagatccc ccagcccagt gctctgccag gaatagacgt   8880

cggctcatct gtaatgtccc cacaggattc ttttaaggaa attcatgtaa atattgaagc   8940

gactttcaaa ccatcaagtg aggaatacct tcacataact gagcctccct ctttatctcc   9000

tgacacaaaa ttagaacctt cagaagatga tggtaaacct gagttattag aagaaatgga   9060

agcttctccc acagaactta ttgctgtgga aggaactgag attctccaag atttccaaaa   9120

caaaaccgat ggtcaagttt ctggagaagc aatcaagatg tttcccacca ttaaaacacc   9180

tgaggctgga actgttatta caactgccga tgaaattgaa ttagaaggtg ctacacagtg   9240

gccacactct acttctgctt ctgccaccta tggggtcgag gcaggtgtgg tgccttggct   9300

aagtccacag acttctgaga ggcccacgct ttcttcttct ccagaaataa accctgaaac   9360

tcaagcagct ttaatcagag ggcaggattc cacgatagca gcatcagaac agcaagtggc   9420

agcgagaatt cttgattcca atgatcaggc aacagtaaac cctgtggaat ttaatactga   9480

ggttgcaaca ccaccatttt cccttctgga gacttctaat gaaacagatt tcctgattgg   9540

cattaatgaa gagtcagtgg aaggcacggc aatctattta ccaggacctg atcgctgcaa   9600

aatgaacccg tgccttaacg gaggcacctg ttatcctact gaaacttcct acgtatgcac   9660

ctgtgtgcca ggatacagcg gagaccagtg tgaacttgat tttgatgaat gtcactctaa   9720

tccctgtcgt aatggagcca cttgtgttga tggttttaac acattcaggt gcctctgcct   9780

tccaagttat gttggtgcac tttgtgagca agataccgag acatgtgact atggctggca   9840

caaattccaa gggcagtgct acaaatactt tgcccatcga cgcacatggg atgcagctga   9900

acgggaatgc cgtctgcagg gtgcccatct cacaagcatc ctgtctcacg aagaacaaat   9960

gtttgttaat cgtgtgggcc atgattatca gtggataggc ctcaatgaca agatgtttga  10020

gcatgacttc cgttggactg atggcagcac actgcaatac gagaattgga gacccaacca  10080

gccagacagc ttcttttctg ctggagaaga ctgtgttgta atcatttggc atgagaatgg  10140

ccagtggaat gatgttccct gcaattacca tctcacctat acgtgcaaga aaggaacagt  10200

cgcttgcggc cagccccctg ttgtagaaaa tgccaagacc tttggaaaga tgaaacctcg  10260

ttatgaaatc aactccctga ttagatacca ctgcaaagat ggtttcattc aacgtcacct  10320

tccaactatc cggtgcttag gaaatggaag atgggctata cctaaaatta cctgcatgaa  10380

cccatctgca taccaaagga cttattctat gaaatacttt aaaaattcct catcagcaaa  10440

ggacaattca ataaatacat ccaaacatga tcatcgttgg agccggaggt ggcaggagtc  10500

gaggcgctga tccctaaaat ggcgaacatg tgttttcatc atttcagcca aagtcctaac  10560

ttcctgtgcc tttcctatca cctcgagaag taattatcag ttggtttgga tttttggacc  10620

accgttcagt cattttgggt tgccgtgctc ccaaaacatt ttaaatgaaa gtattggcat  10680

tcaaaaagac agcagacaaa atgaaagaaa atgagagcag aaagtaagca tttccagcct  10740

atctaatttc tttagttttc tatttgcctc cagtgcagtc catttcctaa tgtataccag  10800

cctactgtac tatttaaaat gctcaatttc agcaccgatg gccatgtaaa taagatgatt  10860

taatgttgat tttaatcctg tatataaaat aaaaagtcac aatgagtttg ggcatattta  10920

atgatgatta tggagcctta gaggtcttta atcattggtt cggctgcttt tatgtagttt  10980

aggctggaaa tggtttcact tgctctttga ctgtcagcaa gactgaagat ggcttttcct  11040

ggacagctag aaaacacaaa atcttgtagg tcattgcacc tatctcagcc ataggtgcag  11100

tttgcttcta catgatgcta aaggctgcga atgggatcct gatggaacta aggactccaa  11160

tgtcgaactc ttctttgctg cattcctttt tcttcactta caagaaaggc ctgaatggag  11220

gacttttctg taaccaggaa cattttttag gggtcaaagt gctaataatt aactcaacca  11280

ggtctacttt ttaatggctt tcataacact aactcataag gttaccgatc aatgcatttc  11340

atacggatat agacctaggg ctctggaggg tgggggattg ttaaaacaca tgcaaaaaaa  11400

aaaaaaaaaa aaaaaaaaga aattttgtat atataaccat tttaatcttt tataaagttt  11460

tgaatgttca tgtatgaatg ctgcagctgt gaagcataca taaataaatg aagtaagcca  11520

tactgattta atttattgga tgttattttc cctaagacct gaaaatgaac atagtatgct  11580

agttattttt cagtgttagc cttttacttt cctcacacaa tttggaatca tataatatag  11640

gtactttgtc cctgattaaa taatgtgacg gatagaatgc atcaagtgtt tattatgaaa  11700

agagtggaaa agtatatagc ttttagcaaa aggtgtttgc ccattctaag aaatgagcga  11760

atatatagaa atagtgtggg catttcttcc tgttaggtgg agtgtatgtg ttgacatttc  11820

tccccatctc ttcccactct gttttctccc cattatttga ataaagtgac tgctgaagat  11880

gactttgaat ccttatccac ttaatttaat gtttaaagaa aaacctgtaa tggaaagtaa  11940

gactccttcc ctaatttcag tttagagcaa cttgaagaag agtagacaaa aaataaaatg  12000

cacatagaaa aagagaaaaa gggcacaaag ggattggccc aatattgatt ctttttt     12057


<210>  3
<211>  2409
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Arg Met Ser Asp 
            340                 345                 350         


Leu Ser Val Ile Gly His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu 
        355                 360                 365             


Pro Cys Ser Glu Glu Thr Asp Pro Val His Asp Leu Met Ala Glu Ile 
    370                 375                 380                 


Leu Pro Glu Phe Pro Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu 
385                 390                 395                 400 


Glu Asn Glu Glu Glu Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr 
                405                 410                 415     


Thr Thr Pro Ser Val Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr 
            420                 425                 430         


Val Pro Lys Asp Pro Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu 
        435                 440                 445             


Ser Val Ala Pro Ser Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr 
    450                 455                 460                 


His Pro Phe Val Ile Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro 
465                 470                 475                 480 


Asn Glu Ser Thr Glu Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro 
                485                 490                 495     


Glu Thr Tyr Pro Glu Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp 
            500                 505                 510         


Val Phe Pro Thr Val Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala 
        515                 520                 525             


Lys Lys Gly Ala Glu Ser Val Thr Glu Arg Asp Thr Glu Val Gly His 
    530                 535                 540                 


Gln Ala His Glu His Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser 
545                 550                 555                 560 


Ser Gly Glu Ile Ala Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala 
                565                 570                 575     


Arg Ala Thr Glu Val Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser 
            580                 585                 590         


Val Thr Tyr Thr Pro Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val 
        595                 600                 605             


Ser Glu Glu Glu Ala Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp 
    610                 615                 620                 


Leu Leu Ser Thr Lys Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val 
625                 630                 635                 640 


Val Glu Leu Ser Gly Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly 
                645                 650                 655     


Glu Ala Glu Glu Asp Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu 
            660                 665                 670         


Ser Gln Arg Asn Thr Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg 
        675                 680                 685             


Ile Ile Thr Glu Ser Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro 
    690                 695                 700                 


Val Ser Glu Gln Pro Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser 
705                 710                 715                 720 


Glu Thr Asp Thr Ser Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys 
                725                 730                 735     


Lys Arg Lys Glu Glu Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu 
            740                 745                 750         


Val Tyr Ser Ser Thr Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu 
        755                 760                 765             


Leu Glu Ser Pro Asn Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys 
    770                 775                 780                 


Ser Phe Met Ser Leu Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr 
785                 790                 795                 800 


Asp Ser Thr Pro Val Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly 
                805                 810                 815     


Ala Gln Thr Thr Glu His Ser Ser Ile His Gln Pro Gly Val Gln Glu 
            820                 825                 830         


Gly Leu Thr Thr Leu Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln 
        835                 840                 845             


Gly Ser Gly Glu Ala Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser 
    850                 855                 860                 


Phe Ser Leu Asn Val Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala 
865                 870                 875                 880 


Gly Thr Leu Ser Pro His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr 
                885                 890                 895     


Gly Leu Val Leu Ser Thr Val Met Asp Arg Val Val Ala Glu Asn Ile 
            900                 905                 910         


Thr Gln Thr Ser Arg Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro 
        915                 920                 925             


Asn Tyr Gly Ala Glu Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu 
    930                 935                 940                 


Glu Asp Phe Ser Gly Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro 
945                 950                 955                 960 


Ile Ala Lys Glu Glu Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala 
                965                 970                 975     


Phe Arg Asp Thr Gln Thr Ser Pro Ser Thr Val Pro Thr Ser Val His 
            980                 985                 990         


Ile Ser His Ile Ser Asp Ser Glu  Gly Pro Ser Ser Thr  Met Val Ser 
        995                 1000                 1005             


Thr Ser  Ala Phe Pro Trp Glu  Glu Phe Thr Ser Ser  Ala Glu Gly 
    1010                 1015                 1020             


Ser Gly  Glu Gln Leu Val Thr  Val Ser Ser Ser Val  Val Pro Val 
    1025                 1030                 1035             


Leu Pro  Ser Ala Val Gln Lys  Phe Ser Gly Thr Ala  Ser Ser Ile 
    1040                 1045                 1050             


Ile Asp  Glu Gly Leu Gly Glu  Val Gly Thr Val Asn  Glu Ile Asp 
    1055                 1060                 1065             


Arg Arg  Ser Thr Ile Leu Pro  Thr Ala Glu Val Glu  Gly Thr Lys 
    1070                 1075                 1080             


Ala Pro  Val Glu Lys Glu Glu  Val Lys Val Ser Gly  Thr Val Ser 
    1085                 1090                 1095             


Thr Asn  Phe Pro Gln Thr Ile  Glu Pro Ala Lys Leu  Trp Ser Arg 
    1100                 1105                 1110             


Gln Glu  Val Asn Pro Val Arg  Gln Glu Ile Glu Ser  Glu Thr Thr 
    1115                 1120                 1125             


Ser Glu  Glu Gln Ile Gln Glu  Glu Lys Ser Phe Glu  Ser Pro Gln 
    1130                 1135                 1140             


Asn Ser  Pro Ala Thr Glu Gln  Thr Ile Phe Asp Ser  Gln Thr Phe 
    1145                 1150                 1155             


Thr Glu  Thr Glu Leu Lys Thr  Thr Asp Tyr Ser Val  Leu Thr Thr 
    1160                 1165                 1170             


Lys Lys  Thr Tyr Ser Asp Asp  Lys Glu Met Lys Glu  Glu Asp Thr 
    1175                 1180                 1185             


Ser Leu  Val Asn Met Ser Thr  Pro Asp Pro Asp Ala  Asn Gly Leu 
    1190                 1195                 1200             


Glu Ser  Tyr Thr Thr Leu Pro  Glu Ala Thr Glu Lys  Ser His Phe 
    1205                 1210                 1215             


Phe Leu  Ala Thr Ala Leu Val  Thr Glu Ser Ile Pro  Ala Glu His 
    1220                 1225                 1230             


Val Val  Thr Asp Ser Pro Ile  Lys Lys Glu Glu Ser  Thr Lys His 
    1235                 1240                 1245             


Phe Pro  Lys Gly Met Arg Pro  Thr Ile Gln Glu Ser  Asp Thr Glu 
    1250                 1255                 1260             


Leu Leu  Phe Ser Gly Leu Gly  Ser Gly Glu Glu Val  Leu Pro Thr 
    1265                 1270                 1275             


Leu Pro  Thr Glu Ser Val Asn  Phe Thr Glu Val Glu  Gln Ile Asn 
    1280                 1285                 1290             


Asn Thr  Leu Tyr Pro His Thr  Ser Gln Val Glu Ser  Thr Ser Ser 
    1295                 1300                 1305             


Asp Lys  Ile Glu Asp Phe Asn  Arg Met Glu Asn Val  Ala Lys Glu 
    1310                 1315                 1320             


Val Gly  Pro Leu Val Ser Gln  Thr Asp Ile Phe Glu  Gly Ser Gly 
    1325                 1330                 1335             


Ser Val  Thr Ser Thr Thr Leu  Ile Glu Ile Leu Ser  Asp Thr Gly 
    1340                 1345                 1350             


Ala Glu  Gly Pro Thr Val Ala  Pro Leu Pro Phe Ser  Thr Asp Ile 
    1355                 1360                 1365             


Gly His  Pro Gln Asn Gln Thr  Val Arg Trp Ala Glu  Glu Ile Gln 
    1370                 1375                 1380             


Thr Ser  Arg Pro Gln Thr Ile  Thr Glu Gln Asp Ser  Asn Lys Asn 
    1385                 1390                 1395             


Ser Ser  Thr Ala Glu Ile Asn  Glu Thr Thr Thr Ser  Ser Thr Asp 
    1400                 1405                 1410             


Phe Leu  Ala Arg Ala Tyr Gly  Phe Glu Met Ala Lys  Glu Phe Val 
    1415                 1420                 1425             


Thr Ser  Ala Pro Lys Pro Ser  Asp Leu Tyr Tyr Glu  Pro Ser Gly 
    1430                 1435                 1440             


Glu Gly  Ser Gly Glu Val Asp  Ile Val Asp Ser Phe  His Thr Ser 
    1445                 1450                 1455             


Ala Thr  Thr Gln Ala Thr Arg  Gln Glu Ser Ser Thr  Thr Phe Val 
    1460                 1465                 1470             


Ser Asp  Gly Ser Leu Glu Lys  His Pro Glu Val Pro  Ser Ala Lys 
    1475                 1480                 1485             


Ala Val  Thr Ala Asp Gly Phe  Pro Thr Val Ser Val  Met Leu Pro 
    1490                 1495                 1500             


Leu His  Ser Glu Gln Asn Lys  Ser Ser Pro Asp Pro  Thr Ser Thr 
    1505                 1510                 1515             


Leu Ser  Asn Thr Val Ser Tyr  Glu Arg Ser Thr Asp  Gly Ser Phe 
    1520                 1525                 1530             


Gln Asp  Arg Phe Arg Glu Phe  Glu Asp Ser Thr Leu  Lys Pro Asn 
    1535                 1540                 1545             


Arg Lys  Lys Pro Thr Glu Asn  Ile Ile Ile Asp Leu  Asp Lys Glu 
    1550                 1555                 1560             


Asp Lys  Asp Leu Ile Leu Thr  Ile Thr Glu Ser Thr  Ile Leu Glu 
    1565                 1570                 1575             


Ile Leu  Pro Glu Leu Thr Ser  Asp Lys Asn Thr Ile  Ile Asp Ile 
    1580                 1585                 1590             


Asp His  Thr Lys Pro Val Tyr  Glu Asp Ile Leu Gly  Met Gln Thr 
    1595                 1600                 1605             


Asp Ile  Asp Thr Glu Val Pro  Ser Glu Pro His Asp  Ser Asn Asp 
    1610                 1615                 1620             


Glu Ser  Asn Asp Asp Ser Thr  Gln Val Gln Glu Ile  Tyr Glu Ala 
    1625                 1630                 1635             


Ala Val  Asn Leu Ser Leu Thr  Glu Glu Thr Phe Glu  Gly Ser Ala 
    1640                 1645                 1650             


Asp Val  Leu Ala Ser Tyr Thr  Gln Ala Thr His Asp  Glu Ser Met 
    1655                 1660                 1665             


Thr Tyr  Glu Asp Arg Ser Gln  Leu Asp His Met Gly  Phe His Phe 
    1670                 1675                 1680             


Thr Thr  Gly Ile Pro Ala Pro  Ser Thr Glu Thr Glu  Leu Asp Val 
    1685                 1690                 1695             


Leu Leu  Pro Thr Ala Thr Ser  Leu Pro Ile Pro Arg  Lys Ser Ala 
    1700                 1705                 1710             


Thr Val  Ile Pro Glu Ile Glu  Gly Ile Lys Ala Glu  Ala Lys Ala 
    1715                 1720                 1725             


Leu Asp  Asp Met Phe Glu Ser  Ser Thr Leu Ser Asp  Gly Gln Ala 
    1730                 1735                 1740             


Ile Ala  Asp Gln Ser Glu Ile  Ile Pro Thr Leu Gly  Gln Phe Glu 
    1745                 1750                 1755             


Arg Thr  Gln Glu Glu Tyr Glu  Asp Lys Lys His Ala  Gly Pro Ser 
    1760                 1765                 1770             


Phe Gln  Pro Glu Phe Ser Ser  Gly Ala Glu Glu Ala  Leu Val Asp 
    1775                 1780                 1785             


His Thr  Pro Tyr Leu Ser Ile  Ala Thr Thr His Leu  Met Asp Gln 
    1790                 1795                 1800             


Ser Val  Thr Glu Val Pro Asp  Val Met Glu Gly Ser  Asn Pro Pro 
    1805                 1810                 1815             


Tyr Tyr  Thr Asp Thr Thr Leu  Ala Val Ser Thr Phe  Ala Lys Leu 
    1820                 1825                 1830             


Ser Ser  Gln Thr Pro Ser Ser  Pro Leu Thr Ile Tyr  Ser Gly Ser 
    1835                 1840                 1845             


Glu Ala  Ser Gly His Thr Glu  Ile Pro Gln Pro Ser  Ala Leu Pro 
    1850                 1855                 1860             


Gly Ile  Asp Val Gly Ser Ser  Val Met Ser Pro Gln  Asp Ser Phe 
    1865                 1870                 1875             


Lys Glu  Ile His Val Asn Ile  Glu Ala Thr Phe Lys  Pro Ser Ser 
    1880                 1885                 1890             


Glu Glu  Tyr Leu His Ile Thr  Glu Pro Pro Ser Leu  Ser Pro Asp 
    1895                 1900                 1905             


Thr Lys  Leu Glu Pro Ser Glu  Asp Asp Gly Lys Pro  Glu Leu Leu 
    1910                 1915                 1920             


Glu Glu  Met Glu Ala Ser Pro  Thr Glu Leu Ile Ala  Val Glu Gly 
    1925                 1930                 1935             


Thr Glu  Ile Leu Gln Asp Phe  Gln Asn Lys Thr Asp  Gly Gln Val 
    1940                 1945                 1950             


Ser Gly  Glu Ala Ile Lys Met  Phe Pro Thr Ile Lys  Thr Pro Glu 
    1955                 1960                 1965             


Ala Gly  Thr Val Ile Thr Thr  Ala Asp Glu Ile Glu  Leu Glu Gly 
    1970                 1975                 1980             


Ala Thr  Gln Trp Pro His Ser  Thr Ser Ala Ser Ala  Thr Tyr Gly 
    1985                 1990                 1995             


Val Glu  Ala Gly Val Val Pro  Trp Leu Ser Pro Gln  Thr Ser Glu 
    2000                 2005                 2010             


Arg Pro  Thr Leu Ser Ser Ser  Pro Glu Ile Asn Pro  Glu Thr Gln 
    2015                 2020                 2025             


Ala Ala  Leu Ile Arg Gly Gln  Asp Ser Thr Ile Ala  Ala Ser Glu 
    2030                 2035                 2040             


Gln Gln  Val Ala Ala Arg Ile  Leu Asp Ser Asn Asp  Gln Ala Thr 
    2045                 2050                 2055             


Val Asn  Pro Val Glu Phe Asn  Thr Glu Val Ala Thr  Pro Pro Phe 
    2060                 2065                 2070             


Ser Leu  Leu Glu Thr Ser Asn  Glu Thr Asp Phe Leu  Ile Gly Ile 
    2075                 2080                 2085             


Asn Glu  Glu Ser Val Glu Gly  Thr Ala Ile Tyr Leu  Pro Gly Pro 
    2090                 2095                 2100             


Asp Arg  Cys Lys Met Asn Pro  Cys Leu Asn Gly Gly  Thr Cys Tyr 
    2105                 2110                 2115             


Pro Thr  Glu Thr Ser Tyr Val  Cys Thr Cys Val Pro  Gly Tyr Ser 
    2120                 2125                 2130             


Gly Asp  Gln Cys Glu Leu Asp  Phe Asp Glu Cys His  Ser Asn Pro 
    2135                 2140                 2145             


Cys Arg  Asn Gly Ala Thr Cys  Val Asp Gly Phe Asn  Thr Phe Arg 
    2150                 2155                 2160             


Cys Leu  Cys Leu Pro Ser Tyr  Val Gly Ala Leu Cys  Glu Gln Asp 
    2165                 2170                 2175             


Thr Glu  Thr Cys Asp Tyr Gly  Trp His Lys Phe Gln  Gly Gln Cys 
    2180                 2185                 2190             


Tyr Lys  Tyr Phe Ala His Arg  Arg Thr Trp Asp Ala  Ala Glu Arg 
    2195                 2200                 2205             


Glu Cys  Arg Leu Gln Gly Ala  His Leu Thr Ser Ile  Leu Ser His 
    2210                 2215                 2220             


Glu Glu  Gln Met Phe Val Asn  Arg Val Gly His Asp  Tyr Gln Trp 
    2225                 2230                 2235             


Ile Gly  Leu Asn Asp Lys Met  Phe Glu His Asp Phe  Arg Trp Thr 
    2240                 2245                 2250             


Asp Gly  Ser Thr Leu Gln Tyr  Glu Asn Trp Arg Pro  Asn Gln Pro 
    2255                 2260                 2265             


Asp Ser  Phe Phe Ser Ala Gly  Glu Asp Cys Val Val  Ile Ile Trp 
    2270                 2275                 2280             


His Glu  Asn Gly Gln Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu 
    2285                 2290                 2295             


Thr Tyr  Thr Cys Lys Lys Gly  Thr Val Ala Cys Gly  Gln Pro Pro 
    2300                 2305                 2310             


Val Val  Glu Asn Ala Lys Thr  Phe Gly Lys Met Lys  Pro Arg Tyr 
    2315                 2320                 2325             


Glu Ile  Asn Ser Leu Ile Arg  Tyr His Cys Lys Asp  Gly Phe Ile 
    2330                 2335                 2340             


Gln Arg  His Leu Pro Thr Ile  Arg Cys Leu Gly Asn  Gly Arg Trp 
    2345                 2350                 2355             


Ala Ile  Pro Lys Ile Thr Cys  Met Asn Pro Ser Ala  Tyr Gln Arg 
    2360                 2365                 2370             


Thr Tyr  Ser Met Lys Tyr Phe  Lys Asn Ser Ser Ser  Ala Lys Asp 
    2375                 2380                 2385             


Asn Ser  Ile Asn Thr Ser Lys  His Asp His Arg Trp  Ser Arg Arg 
    2390                 2395                 2400             


Trp Gln  Glu Ser Arg Arg 
    2405                 


