Sequence list 

                         SEQUENCE LISTING

<110>  University of Aarhus
 
<120>  SorCS1 for use in the treatment of insulin resistance

<130>  P2059DK00

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  1168
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1168)
<223>  preproSorCS1b, Isoform 1

<400>  1

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  Ser Ala Met Leu Met  Leu Leu Ser Val Val  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Val Phe Val Ile Tyr  Lys Phe Lys Arg Arg  Val Ala Leu 
    1115                 1120                 1125             


Pro Ser  Pro Pro Ser Pro Ser  Thr Gln Pro Gly Asp  Ser Ser Leu 
    1130                 1135                 1140             


Arg Leu  Gln Arg Ala Arg His  Ala Thr Pro Pro Ser  Thr Pro Lys 
    1145                 1150                 1155             


Arg Gly  Ser Ala Gly Ala Gln  Tyr Ala Ile 
    1160                 1165             


<210>  2
<211>  1197
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1197)
<223>  preproSorCS1, Isoform 2

<400>  2

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
        355                 360                 365             


Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly 
    370                 375                 380                 


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
385                 390                 395                 400 


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
                405                 410                 415     


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
            420                 425                 430         


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
        435                 440                 445             


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile 
    450                 455                 460                 


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
465                 470                 475                 480 


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
                485                 490                 495     


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
            500                 505                 510         


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
        515                 520                 525             


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp 
    530                 535                 540                 


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
545                 550                 555                 560 


Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
                565                 570                 575     


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
            580                 585                 590         


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
        595                 600                 605             


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
    610                 615                 620                 


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
625                 630                 635                 640 


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
                645                 650                 655     


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
            660                 665                 670         


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
        675                 680                 685             


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
    690                 695                 700                 


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Gly Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Val Pro  Gly Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Thr  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Pro Ala Gly Glu Asn  Lys Arg Ser Thr Asp  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Leu Leu Ile  His Thr Leu Asn Gln  Asn Ser Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Arg Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile 
    1115                 1120                 1125             


Asn Val  Tyr Ala Gln Met Gln  Asn Glu Lys Glu Gln  Glu Met Ile 
    1130                 1135                 1140             


Ser Pro  Val Ser His Ser Glu  Ser Arg Pro Asn Val  Pro Gln Thr 
    1145                 1150                 1155             


Glu Leu  Arg Arg Pro Gly Gln  Leu Ile Asp Glu Lys  Val Glu Ser 
    1160                 1165                 1170             


Gln Leu  Ile Gly Ser Ile Ser  Ile Val Ala Glu Asn  Gln Ser Thr 
    1175                 1180                 1185             


Lys Glu  Ile Pro Thr Tyr Val  Asn Val 
    1190                 1195         


<210>  3
<211>  1179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1179)
<223>  preproSorCS1c, Isoform 3

<400>  3

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  Ser Ala Met Leu Met  Leu Leu Ser Val Val  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Val Phe Val Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly 
    1115                 1120                 1125             


Ile Asn  Val Tyr Ala Gln Met  Gln Asn Glu Lys Glu  Gln Glu Met 
    1130                 1135                 1140             


Ile Ser  Pro Val Ser His Ser  Glu Ser Arg Pro Asn  Val Pro Gln 
    1145                 1150                 1155             


Thr Glu  Leu Arg Arg Pro Gly  Gln Leu Ile Asp Glu  Lys Val Glu 
    1160                 1165                 1170             


Ser Gln  Leu Ile Gly Lys 
    1175                 


<210>  4
<211>  1159
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1159)
<223>  preproSorCS1a, Isoform 4

<400>  4

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  Ser Ala Met Leu Met  Leu Leu Ser Val Val  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Val Phe Val Ile Tyr  Lys Phe Lys Arg Cys  Val Ser Leu 
    1115                 1120                 1125             


Tyr Pro  Arg Ser Pro Thr Pro  Asp Leu Phe Leu Leu  Pro Asp Arg 
    1130                 1135                 1140             


Phe Arg  Ser Met Cys Tyr Ser  Asp Val His Ser Ser  Asp Gly Phe 
    1145                 1150                 1155             


Tyr 
    


<210>  5
<211>  1100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1100)
<223>  Soluble preproSorCS1

<400>  5

Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Ile Leu Cys Ala Pro Gly Val Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg 
        35                  40                  45              


Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly 
                85                  90                  95      


Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
705                 710                 715                 720 


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
                725                 730                 735     


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
            740                 745                 750         


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
        755                 760                 765             


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
    770                 775                 780                 


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
785                 790                 795                 800 


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
                805                 810                 815     


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
            820                 825                 830         


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
        835                 840                 845             


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile 
    850                 855                 860                 


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
865                 870                 875                 880 


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
                885                 890                 895     


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
            900                 905                 910         


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
        915                 920                 925             


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg 
    930                 935                 940                 


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
945                 950                 955                 960 


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
                965                 970                 975     


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
            980                 985                 990         


Asp Ile Pro Glu Trp Arg Arg Asp  Ile Gly Arg Val Ile  Lys Lys Ser 
        995                 1000                 1005             


Leu Val  Glu Ala Thr Gly Val  Pro Gly Gln His Ile  Leu Val Ala 
    1010                 1015                 1020             


Val Leu  Pro Gly Leu Pro Thr  Thr Ala Glu Leu Phe  Val Leu Pro 
    1025                 1030                 1035             


Tyr Gln  Asp Pro Ala Gly Glu  Asn Lys Arg Ser Thr  Asp Asp Leu 
    1040                 1045                 1050             


Glu Gln  Ile Ser Glu Leu Leu  Ile His Thr Leu Asn  Gln Asn Ser 
    1055                 1060                 1065             


Val His  Phe Glu Leu Lys Pro  Gly Val Arg Val Leu  Val His Ala 
    1070                 1075                 1080             


Ala His  Leu Thr Ala Ala Pro  Leu Val Asp Leu Thr  Pro Thr His 
    1085                 1090                 1095             


Ser Gly  
    1100 


<210>  6
<211>  1134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1134)
<223>  proSorCS1b, Isoform 1

<400>  6

Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg Ser 
1               5                   10                  15      


Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala 
    50                  55                  60                  


Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
        675                 680                 685             


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    690                 695                 700                 


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
705                 710                 715                 720 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                725                 730                 735     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            740                 745                 750         


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
        755                 760                 765             


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    770                 775                 780                 


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
785                 790                 795                 800 


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
                805                 810                 815     


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
            820                 825                 830         


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
        835                 840                 845             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    850                 855                 860                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
865                 870                 875                 880 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
                885                 890                 895     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe 
            900                 905                 910         


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        915                 920                 925             


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
    930                 935                 940                 


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
945                 950                 955                 960 


Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu 
                965                 970                 975     


Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu 
            980                 985                 990         


Pro Gly Pro Thr Thr Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Pro 
        995                 1000                 1005             


Ala Gly  Glu Asn Lys Arg Ser  Thr Asp Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Leu  Leu Ile His Thr Leu  Asn Gln Asn Ser Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Arg Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Arg Val Ala Leu Pro  Ser Pro Pro 
    1085                 1090                 1095             


Ser Pro  Ser Thr Gln Pro Gly  Asp Ser Ser Leu Arg  Leu Gln Arg 
    1100                 1105                 1110             


Ala Arg  His Ala Thr Pro Pro  Ser Thr Pro Lys Arg  Gly Ser Ala 
    1115                 1120                 1125             


Gly Ala  Gln Tyr Ala Ile 
    1130                 


<210>  7
<211>  1164
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1164)
<223>  proSorCS1, Isoform 2

<400>  7

Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg Ser 
1               5                   10                  15      


Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala 
    50                  55                  60                  


Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp Ser 
                325                 330                 335     


Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly Gly 
            340                 345                 350         


Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln Met 
        355                 360                 365             


Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser Thr 
    370                 375                 380                 


Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn Asp 
385                 390                 395                 400 


Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu 
                405                 410                 415     


Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile Met 
            420                 425                 430         


Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala Asn 
        435                 440                 445             


Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly 
    450                 455                 460                 


Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly Asp 
465                 470                 475                 480 


Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu Lys 
                485                 490                 495     


Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp Thr 
            500                 505                 510         


Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu Ser 
        515                 520                 525             


Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp 
    530                 535                 540                 


Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln Gly 
545                 550                 555                 560 


Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His Leu 
                565                 570                 575     


Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe Thr 
            580                 585                 590         


Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu Glu 
        595                 600                 605             


Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp 
    610                 615                 620                 


Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala 
625                 630                 635                 640 


Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala Cys 
                645                 650                 655     


Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys 
            660                 665                 670         


Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Thr Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Pro 
        995                 1000                 1005             


Ala Gly  Glu Asn Lys Arg Ser  Thr Asp Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Leu  Leu Ile His Thr Leu  Asn Gln Asn Ser Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Arg Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Lys Ile Pro Gly Ile  Asn Val Tyr 
    1085                 1090                 1095             


Ala Gln  Met Gln Asn Glu Lys  Glu Gln Glu Met Ile  Ser Pro Val 
    1100                 1105                 1110             


Ser His  Ser Glu Ser Arg Pro  Asn Val Pro Gln Thr  Glu Leu Arg 
    1115                 1120                 1125             


Arg Pro  Gly Gln Leu Ile Asp  Glu Lys Val Glu Ser  Gln Leu Ile 
    1130                 1135                 1140             


Gly Ser  Ile Ser Ile Val Ala  Glu Asn Gln Ser Thr  Lys Glu Ile 
    1145                 1150                 1155             


Pro Thr  Tyr Val Asn Val 
    1160                 


<210>  8
<211>  1146
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1146)
<223>  proSorCS1c, Isoform 3

<400>  8

Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg Ser 
1               5                   10                  15      


Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala 
    50                  55                  60                  


Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
        675                 680                 685             


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    690                 695                 700                 


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
705                 710                 715                 720 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                725                 730                 735     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            740                 745                 750         


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
        755                 760                 765             


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    770                 775                 780                 


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
785                 790                 795                 800 


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
                805                 810                 815     


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
            820                 825                 830         


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
        835                 840                 845             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    850                 855                 860                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
865                 870                 875                 880 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
                885                 890                 895     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe 
            900                 905                 910         


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        915                 920                 925             


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
    930                 935                 940                 


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
945                 950                 955                 960 


Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu 
                965                 970                 975     


Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu 
            980                 985                 990         


Pro Gly Leu Pro Thr Thr Ala Glu  Leu Phe Val Leu Pro  Tyr Gln Asp 
        995                 1000                 1005             


Pro Ala  Gly Glu Asn Lys Arg  Ser Thr Asp Asp Leu  Glu Gln Ile 
    1010                 1015                 1020             


Ser Glu  Leu Leu Ile His Thr  Leu Asn Gln Asn Ser  Val His Phe 
    1025                 1030                 1035             


Glu Leu  Lys Pro Gly Val Arg  Val Leu Val His Ala  Ala His Leu 
    1040                 1045                 1050             


Thr Ala  Ala Pro Leu Val Asp  Leu Thr Pro Thr His  Ser Gly Ser 
    1055                 1060                 1065             


Ala Met  Leu Met Leu Leu Ser  Val Val Phe Val Gly  Leu Ala Val 
    1070                 1075                 1080             


Phe Val  Ile Tyr Lys Phe Lys  Arg Lys Ile Pro Gly  Ile Asn Val 
    1085                 1090                 1095             


Tyr Ala  Gln Met Gln Asn Glu  Lys Glu Gln Glu Met  Ile Ser Pro 
    1100                 1105                 1110             


Val Ser  His Ser Glu Ser Arg  Pro Asn Val Pro Gln  Thr Glu Leu 
    1115                 1120                 1125             


Arg Arg  Pro Gly Gln Leu Ile  Asp Glu Lys Val Glu  Ser Gln Leu 
    1130                 1135                 1140             


Ile Gly  Lys 
    1145     


<210>  9
<211>  1125
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1125)
<223>  proSorCS1a, Isoform 4

<400>  9

Gly Gly Ser Cys Cys Pro Ser Pro His Pro Ser Ser Ala Pro Arg Ser 
1               5                   10                  15      


Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala 
    50                  55                  60                  


Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ala Ser Lys Asp Thr 
            500                 505                 510         


Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu Ser 
        515                 520                 525             


Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp 
    530                 535                 540                 


Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln Gly 
545                 550                 555                 560 


Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His Leu 
                565                 570                 575     


Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe Thr 
            580                 585                 590         


Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu Glu 
        595                 600                 605             


Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp 
    610                 615                 620                 


Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala 
625                 630                 635                 640 


Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala Cys 
                645                 650                 655     


Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys 
            660                 665                 670         


Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Thr Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Pro 
        995                 1000                 1005             


Ala Gly  Glu Asn Lys Arg Ser  Thr Asp Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Leu  Leu Ile His Thr Leu  Asn Gln Asn Ser Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Arg Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Cys Val Ser Leu Tyr  Pro Arg Ser 
    1085                 1090                 1095             


Pro Thr  Pro Asp Leu Phe Leu  Leu Pro Asp Arg Phe  Arg Ser Met 
    1100                 1105                 1110             


Cys Tyr  Ser Asp Val His Ser  Ser Asp Gly Phe Tyr  
    1115                 1120                 1125 


<210>  10
<211>  1046
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1046)
<223>  Soluble proSorCS1

<400>  10

Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala Pro Ala Thr Pro Leu 
1               5                   10                  15      


Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala Pro Gly Asp Arg Ala 
            20                  25                  30          


Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala Ser Met Ala Val Ala 
        35                  40                  45              


Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala Asp Gln Glu Lys Ala 
    50                  55                  60                  


Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg Gly Val Leu Arg Asp 
65                  70                  75                  80  


Gly Gly Gln Gln Glu Pro Gly Thr Arg Glu Arg Asp Pro Asp Lys Ala 
                85                  90                  95      


Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr Ser Thr Thr Phe Ala 
            100                 105                 110         


Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly 
        115                 120                 125             


His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr Asn 
    130                 135                 140                 


Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly 
145                 150                 155                 160 


Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Ile Leu 
                165                 170                 175     


Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg Lys Ile Met Leu Leu 
            180                 185                 190         


Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile Ser Ser Asp Glu Gly 
        195                 200                 205             


Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr Ile Gln Ser Leu Leu 
    210                 215                 220                 


Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp Gln 
225                 230                 235                 240 


Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg Trp Gln Leu Ile Gln 
                245                 250                 255     


Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser Val Met Gly Ser Asn 
            260                 265                 270         


Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg Thr Val Asp Gly His 
        275                 280                 285             


Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys Thr Glu Ala Asn Arg 
    290                 295                 300                 


Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp Ser Leu Ile Val Gln 
305                 310                 315                 320 


Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly Gly Arg Pro His Tyr 
                325                 330                 335     


Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln Met Lys Leu Pro Lys 
            340                 345                 350         


Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser Thr Asp Glu Asn Gln 
        355                 360                 365             


Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu 
    370                 375                 380                 


Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu Asn 
385                 390                 395                 400 


Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile Met Ile Asp Leu Tyr 
                405                 410                 415     


Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala Asn Lys Lys Ile Asp 
            420                 425                 430         


Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg 
        435                 440                 445             


Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly Asp Pro Val His Cys 
    450                 455                 460                 


Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu Lys Val Ser Glu Asn 
465                 470                 475                 480 


Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp Thr Ala Pro Ser Ile 
                485                 490                 495     


Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu Ser Asp Thr Asp Ile 
            500                 505                 510         


Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile Phe 
        515                 520                 525             


Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln Gly Gly Val Leu Val 
    530                 535                 540                 


Ala Met Lys His Thr Ser Leu Pro Ile Arg His Leu Trp Leu Ser Phe 
545                 550                 555                 560 


Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe Thr Ser Ile Pro Leu 
                565                 570                 575     


Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile Met 
            580                 585                 590         


Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp Gln Leu Val Lys 
        595                 600                 605             


Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp Tyr 
    610                 615                 620                 


Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala Cys Ile Met Gly Ala 
625                 630                 635                 640 


Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys Cys Met Gln Gly 
                645                 650                 655     


Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val Cys Thr Glu Ala 
            660                 665                 670         


Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser Asn Gly Gln Cys 
        675                 680                 685             


Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser Lys Asp Cys Ser 
    690                 695                 700                 


Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Lys Val Val Ser 
705                 710                 715                 720 


Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro Gln 
                725                 730                 735     


Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile Val Thr Ala Asp 
            740                 745                 750         


Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr Leu Met Val Gln 
        755                 760                 765             


Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln Val Asp Phe Gly 
    770                 775                 780                 


Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser Met Glu Asp Gly 
785                 790                 795                 800 


Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg Val Thr Val Gln 
                805                 810                 815     


Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu Tyr Leu His Val 
            820                 825                 830         


Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro Phe Val Thr Thr 
        835                 840                 845             


Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp Pro Ser Gln Val 
    850                 855                 860                 


Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn Thr Glu Pro Leu 
865                 870                 875                 880 


Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe Thr Ser Glu Gly Met 
                885                 890                 895     


Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala Ile Leu Gln Asp 
            900                 905                 910         


Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser Leu Arg Leu Ser 
        915                 920                 925             


Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile Pro Glu Trp Arg 
    930                 935                 940                 


Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu Val Glu Ala Thr Gly 
945                 950                 955                 960 


Val Pro Gly Gln His Ile Leu Val Ala Val Leu Pro Gly Leu Pro Thr 
                965                 970                 975     


Thr Ala Glu Leu Phe Val Leu Pro Tyr Gln Asp Pro Ala Gly Glu Asn 
            980                 985                 990         


Lys Arg Ser Thr Asp Asp Leu Glu  Gln Ile Ser Glu Leu  Leu Ile His 
        995                 1000                 1005             


Thr Leu  Asn Gln Asn Ser Val  His Phe Glu Leu Lys  Pro Gly Val 
    1010                 1015                 1020             


Arg Val  Leu Val His Ala Ala  His Leu Thr Ala Ala  Pro Leu Val 
    1025                 1030                 1035             


Asp Leu  Thr Pro Thr His Ser  Gly 
    1040                 1045     


<210>  11
<211>  1058
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1058)
<223>  Mature SorCS1b, Isoform 1

<400>  11

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Arg Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala 
            980                 985                 990         


Met Leu Met Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
        995                 1000                 1005             


Ile Tyr  Lys Phe Lys Arg Arg  Val Ala Leu Pro Ser  Pro Pro Ser 
    1010                 1015                 1020             


Pro Ser  Thr Gln Pro Gly Asp  Ser Ser Leu Arg Leu  Gln Arg Ala 
    1025                 1030                 1035             


Arg His  Ala Thr Pro Pro Ser  Thr Pro Lys Arg Gly  Ser Ala Gly 
    1040                 1045                 1050             


Ala Gln  Tyr Ala Ile 
    1055             


<210>  12
<211>  1087
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1087)
<223>  Mature SorCS1, Isoform 2

<400>  12

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Arg Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Gln Pro Phe Pro Gly Tyr Ile Asp 
                245                 250                 255     


Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr 
            260                 265                 270         


Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe 
        275                 280                 285             


Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val 
    290                 295                 300                 


Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn 
305                 310                 315                 320 


Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr 
                325                 330                 335     


Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly 
            340                 345                 350         


Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe 
        355                 360                 365             


Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr 
    370                 375                 380                 


Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu 
385                 390                 395                 400 


Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu 
                405                 410                 415     


His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser 
            420                 425                 430         


Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser 
        435                 440                 445             


Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly 
    450                 455                 460                 


Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu 
465                 470                 475                 480 


Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile 
                485                 490                 495     


Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr 
            500                 505                 510         


Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro 
        515                 520                 525             


Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg 
    530                 535                 540                 


Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg 
545                 550                 555                 560 


Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly 
                565                 570                 575     


Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser 
            580                 585                 590         


Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Met Gln  Asn Glu Lys Glu Gln  Glu Met Ile Ser Pro  Val Ser His 
    1025                 1030                 1035             


Ser Glu  Ser Arg Pro Asn Val  Pro Gln Thr Glu Leu  Arg Arg Pro 
    1040                 1045                 1050             


Gly Gln  Leu Ile Asp Glu Lys  Val Glu Ser Gln Leu  Ile Gly Ser 
    1055                 1060                 1065             


Ile Ser  Ile Val Ala Glu Asn  Gln Ser Thr Lys Glu  Ile Pro Thr 
    1070                 1075                 1080             


Tyr Val  Asn Val 
    1085         


<210>  13
<211>  1069
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1069)
<223>  Mature SorCS1c, Isoform 3

<400>  13

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Arg Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala 
            980                 985                 990         


Met Leu Met Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
        995                 1000                 1005             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Ile Asn  Val Tyr Ala 
    1010                 1015                 1020             


Gln Met  Gln Asn Glu Lys Glu  Gln Glu Met Ile Ser  Pro Val Ser 
    1025                 1030                 1035             


His Ser  Glu Ser Arg Pro Asn  Val Pro Gln Thr Glu  Leu Arg Arg 
    1040                 1045                 1050             


Pro Gly  Gln Leu Ile Asp Glu  Lys Val Glu Ser Gln  Leu Ile Gly 
    1055                 1060                 1065             


Lys 
    


<210>  14
<211>  1048
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1048)
<223>  Mature SorCS1a, Isoform 4

<400>  14

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Arg Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ala Ser 
            420                 425                 430         


Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser 
        435                 440                 445             


Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly 
    450                 455                 460                 


Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu 
465                 470                 475                 480 


Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile 
                485                 490                 495     


Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr 
            500                 505                 510         


Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro 
        515                 520                 525             


Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg 
    530                 535                 540                 


Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg 
545                 550                 555                 560 


Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly 
                565                 570                 575     


Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser 
            580                 585                 590         


Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Cys Val  Ser Leu Tyr Pro Arg  Ser Pro Thr 
    1010                 1015                 1020             


Pro Asp  Leu Phe Leu Leu Pro  Asp Arg Phe Arg Ser  Met Cys Tyr 
    1025                 1030                 1035             


Ser Asp  Val His Ser Ser Asp  Gly Phe Tyr 
    1040                 1045             


<210>  15
<211>  990
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(990)
<223>  Soluble mature SorCS1

<400>  15

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Arg Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly 
            980                 985                 990 


<210>  16
<211>  1167
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1167)
<223>  preproSorCS1b, isoform 1

<400>  16

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Arg Val  Ala Leu Pro 
    1115                 1120                 1125             


Ser Pro  Pro Ser Pro Ser Ala  Gln Pro Gly Asp Ser  Ser Leu Arg 
    1130                 1135                 1140             


Leu Gln  Arg Pro Arg Pro Ala  Thr Pro Pro Ser Ser  Pro Lys Arg 
    1145                 1150                 1155             


Gly Ser  Ala Gly Ala Gln Phe  Ala Ile 
    1160                 1165         


<210>  17
<211>  1147
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1147)
<223>  preproSorCS1b, isoform 2

<400>  17

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Cys Val  Phe Leu Leu 
    1115                 1120                 1125             


Leu Pro  Ser Tyr Pro Arg Pro  Pro Pro Pro Ser Ser  Phe Cys Gln 
    1130                 1135                 1140             


Val Gln  Lys Gln 
    1145         


<210>  18
<211>  1178
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1178)
<223>  preproSorCS1c, isoform 3

<400>  18

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile 
    1115                 1120                 1125             


Asn Val  Tyr Ala Gln Met Gln  Asn Glu Lys Glu Gln  Glu Leu Ile 
    1130                 1135                 1140             


Asn Pro  Val Ser His Ser Glu  Ser Arg Pro Ser Val  Pro His Pro 
    1145                 1150                 1155             


Asp Leu  Arg Arg Pro Gly Gln  Leu Val Asp Glu Lys  Val Glu Ser 
    1160                 1165                 1170             


Gln Leu  Leu Gly Lys 
    1175             


<210>  19
<211>  1178
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1178)
<223>  preproSorCS1c+, isoform 4

<400>  19

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile 
    1115                 1120                 1125             


Asn Val  Tyr Ala Gln Met Gln  Asn Glu Lys Glu Gln  Glu Leu Ile 
    1130                 1135                 1140             


Asn Pro  Val Ser His Ser Glu  Ser Arg Ser Ser Val  Pro His Pro 
    1145                 1150                 1155             


Asp Leu  Arg Arg Pro Gly Gln  Leu Val Asp Glu Lys  Val Glu Ser 
    1160                 1165                 1170             


Gln Leu  Leu Gly Glu 
    1175             


<210>  20
<211>  1191
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1191)
<223>  preproSorCS1d

<400>  20

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly Ser  Ala Met Leu Met Leu  Leu Ser Val Val Phe  Val Gly Leu 
    1100                 1105                 1110             


Ala Val  Phe Val Ile Tyr Lys  Phe Lys Arg Gly Trp  Arg Asp Arg 
    1115                 1120                 1125             


Ser Ala  Val Lys Asn Ile Gly  Cys Ser Cys Arg Gly  Pro Gly Phe 
    1130                 1135                 1140             


Asn Ser  Gln His Gln Gln Gly  Gly Ser Gln Ala Ser  Val Thr Ser 
    1145                 1150                 1155             


Val Pro  Arg Asp Pro Ser Pro  Ser Ser Asp Leu His  Gly His Gln 
    1160                 1165                 1170             


Glu His  Thr Trp Cys Thr Asp  Ile His Pro Gly Lys  Thr Pro Ile 
    1175                 1180                 1185             


His Ile  Lys 
    1190     


<210>  21
<211>  1099
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1099)
<223>  Soluble preproSorCS1

<400>  21

Met Gly Lys Val Gly Ala Gly Asp Gly Ser Ser Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Met Leu Leu Ala Pro Gly Val Cys 
            20                  25                  30          


Ser Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg 
        35                  40                  45              


Arg Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg 
                85                  90                  95      


Val Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly 
            100                 105                 110         


Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg 
        115                 120                 125             


Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala 
    130                 135                 140                 


Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser 
                645                 650                 655     


Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg 
            660                 665                 670         


Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu 
        675                 680                 685             


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
    690                 695                 700                 


Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
705                 710                 715                 720 


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
                725                 730                 735     


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
            740                 745                 750         


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr 
        755                 760                 765             


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
    770                 775                 780                 


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
785                 790                 795                 800 


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
                805                 810                 815     


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
            820                 825                 830         


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
        835                 840                 845             


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
    850                 855                 860                 


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
865                 870                 875                 880 


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
                885                 890                 895     


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
            900                 905                 910         


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
        915                 920                 925             


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
    930                 935                 940                 


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
945                 950                 955                 960 


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
                965                 970                 975     


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
            980                 985                 990         


Ile Pro Glu Trp Arg Arg Asp Ile  Ser Arg Val Ile Lys  Lys Ser Leu 
        995                 1000                 1005             


Val Glu  Ala Thr Gly Ile Pro  Ser Gln His Ile Leu  Val Ala Val 
    1010                 1015                 1020             


Leu Pro  Gly Leu Pro Thr Ala  Ala Glu Leu Phe Val  Leu Pro Tyr 
    1025                 1030                 1035             


Gln Asp  Gly Thr Arg Glu Asn  Lys Arg Ser Pro Glu  Asp Leu Glu 
    1040                 1045                 1050             


Gln Ile  Ser Glu Val Leu Ile  His Lys Leu Asn Gln  Asn Leu Val 
    1055                 1060                 1065             


His Phe  Glu Leu Lys Pro Gly  Val Gln Val Leu Val  His Ala Ala 
    1070                 1075                 1080             


His Leu  Thr Ala Ala Pro Leu  Val Asp Leu Thr Pro  Thr His Ser 
    1085                 1090                 1095             


Gly 
    


<210>  22
<211>  1134
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1134)
<223>  proSorCS1b (isoform 1)

<400>  22

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ala Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly 
        995                 1000                 1005             


Thr Arg  Glu Asn Lys Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Val  Leu Ile His Lys Leu  Asn Gln Asn Leu Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Gln Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Arg Val Ala Leu Pro  Ser Pro Pro 
    1085                 1090                 1095             


Ser Pro  Ser Ala Gln Pro Gly  Asp Ser Ser Leu Arg  Leu Gln Arg 
    1100                 1105                 1110             


Pro Arg  Pro Ala Thr Pro Pro  Ser Ser Pro Lys Arg  Gly Ser Ala 
    1115                 1120                 1125             


Gly Ala  Gln Phe Ala Ile 
    1130                 


<210>  23
<211>  1114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1114)
<223>  proSorCS1a, isoform 2

<400>  23

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ala Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly 
        995                 1000                 1005             


Thr Arg  Glu Asn Lys Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Val  Leu Ile His Lys Leu  Asn Gln Asn Leu Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Gln Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Cys Val Phe Leu Leu  Leu Pro Ser 
    1085                 1090                 1095             


Tyr Pro  Arg Pro Pro Pro Pro  Ser Ser Phe Cys Gln  Val Gln Lys 
    1100                 1105                 1110             


Gln 
    


<210>  24
<211>  1145
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1145)
<223>  proSorCS1c, isoform 3

<400>  24

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ala Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly 
        995                 1000                 1005             


Thr Arg  Glu Asn Lys Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Val  Leu Ile His Lys Leu  Asn Gln Asn Leu Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Gln Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Lys Ile Pro Gly Ile  Asn Val Tyr 
    1085                 1090                 1095             


Ala Gln  Met Gln Asn Glu Lys  Glu Gln Glu Leu Ile  Asn Pro Val 
    1100                 1105                 1110             


Ser His  Ser Glu Ser Arg Pro  Ser Val Pro His Pro  Asp Leu Arg 
    1115                 1120                 1125             


Arg Pro  Gly Gln Leu Val Asp  Glu Lys Val Glu Ser  Gln Leu Leu 
    1130                 1135                 1140             


Gly Lys  
    1145 


<210>  25
<211>  1144
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1144)
<223>  proSorCS1c+, isoform 4

<400>  25

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys Leu 
145                 150                 155                 160 


Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg Ser 
                165                 170                 175     


Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly Leu 
            180                 185                 190         


Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys Lys 
        195                 200                 205             


Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile Ser 
    210                 215                 220                 


Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr Leu 
225                 230                 235                 240 


Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala Tyr 
                245                 250                 255     


Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg Trp 
            260                 265                 270         


Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser Val 
        275                 280                 285             


Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg Thr 
    290                 295                 300                 


Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys Thr 
305                 310                 315                 320 


Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp Ser 
                325                 330                 335     


Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly Gly 
            340                 345                 350         


Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln Met 
        355                 360                 365             


Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser Thr 
    370                 375                 380                 


Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn Asp 
385                 390                 395                 400 


Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu 
                405                 410                 415     


Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val Met 
            420                 425                 430         


Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala Asn 
        435                 440                 445             


Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly 
    450                 455                 460                 


Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly Asp 
465                 470                 475                 480 


Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu Lys 
                485                 490                 495     


Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp Thr 
            500                 505                 510         


Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu Ser 
        515                 520                 525             


Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp 
    530                 535                 540                 


Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln Gly 
545                 550                 555                 560 


Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His Leu 
                565                 570                 575     


Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe Thr 
            580                 585                 590         


Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu Glu 
        595                 600                 605             


Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp 
    610                 615                 620                 


Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala 
625                 630                 635                 640 


Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala Cys 
                645                 650                 655     


Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys 
            660                 665                 670         


Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val Cys 
        675                 680                 685             


Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser Asn 
    690                 695                 700                 


Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser Lys 
705                 710                 715                 720 


Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg Lys 
                725                 730                 735     


Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr Ala 
            740                 745                 750         


Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile Val 
        755                 760                 765             


Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr Leu 
    770                 775                 780                 


Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln Val 
785                 790                 795                 800 


Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser Met 
                805                 810                 815     


Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg Val 
            820                 825                 830         


Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu Tyr 
        835                 840                 845             


Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro Phe 
    850                 855                 860                 


Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp Pro 
865                 870                 875                 880 


Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn Thr 
                885                 890                 895     


Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr Ser 
            900                 905                 910         


Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala Ile 
        915                 920                 925             


Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser Leu 
    930                 935                 940                 


Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile Pro 
945                 950                 955                 960 


Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val Glu 
                965                 970                 975     


Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro Gly 
            980                 985                 990         


Leu Pro Thr Ala Ala Glu Leu Phe  Val Leu Pro Tyr Gln  Asp Gly Thr 
        995                 1000                 1005             


Arg Glu  Asn Lys Arg Ser Pro  Glu Asp Leu Glu Gln  Ile Ser Glu 
    1010                 1015                 1020             


Val Leu  Ile His Lys Leu Asn  Gln Asn Leu Val His  Phe Glu Leu 
    1025                 1030                 1035             


Lys Pro  Gly Val Gln Val Leu  Val His Ala Ala His  Leu Thr Ala 
    1040                 1045                 1050             


Ala Pro  Leu Val Asp Leu Thr  Pro Thr His Ser Gly  Ser Ala Met 
    1055                 1060                 1065             


Leu Met  Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
    1070                 1075                 1080             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Ile Asn  Val Tyr Ala 
    1085                 1090                 1095             


Gln Met  Gln Asn Glu Lys Glu  Gln Glu Leu Ile Asn  Pro Val Ser 
    1100                 1105                 1110             


His Ser  Glu Ser Arg Ser Ser  Val Pro His Pro Asp  Leu Arg Arg 
    1115                 1120                 1125             


Pro Gly  Gln Leu Val Asp Glu  Lys Val Glu Ser Gln  Leu Leu Gly 
    1130                 1135                 1140             


Glu 
    


<210>  26
<211>  1158
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1158)
<223>  proSorCS1d

<400>  26

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ala Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly 
        995                 1000                 1005             


Thr Arg  Glu Asn Lys Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Val  Leu Ile His Lys Leu  Asn Gln Asn Leu Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Gln Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala 
    1055                 1060                 1065             


Met Leu  Met Leu Leu Ser Val  Val Phe Val Gly Leu  Ala Val Phe 
    1070                 1075                 1080             


Val Ile  Tyr Lys Phe Lys Arg  Gly Trp Arg Asp Arg  Ser Ala Val 
    1085                 1090                 1095             


Lys Asn  Ile Gly Cys Ser Cys  Arg Gly Pro Gly Phe  Asn Ser Gln 
    1100                 1105                 1110             


His Gln  Gln Gly Gly Ser Gln  Ala Ser Val Thr Ser  Val Pro Arg 
    1115                 1120                 1125             


Asp Pro  Ser Pro Ser Ser Asp  Leu His Gly His Gln  Glu His Thr 
    1130                 1135                 1140             


Trp Cys  Thr Asp Ile His Pro  Gly Lys Thr Pro Ile  His Ile Lys 
    1145                 1150                 1155             


<210>  27
<211>  1066
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1066)
<223>  Soluble proSorCS1

<400>  27

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Arg 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Pro His Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Thr 
65                  70                  75                  80  


Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Cys 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
        755                 760                 765             


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
                805                 810                 815     


Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe Thr 
            900                 905                 910         


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ala Ala Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly 
        995                 1000                 1005             


Thr Arg  Glu Asn Lys Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser 
    1010                 1015                 1020             


Glu Val  Leu Ile His Lys Leu  Asn Gln Asn Leu Val  His Phe Glu 
    1025                 1030                 1035             


Leu Lys  Pro Gly Val Gln Val  Leu Val His Ala Ala  His Leu Thr 
    1040                 1045                 1050             


Ala Ala  Pro Leu Val Asp Leu  Thr Pro Thr His Ser  Gly 
    1055                 1060                 1065     


<210>  28
<211>  1057
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1057)
<223>  mature SorCS1b, isoform 1

<400>  28

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Arg Val  Ala Leu Pro Ser Pro  Pro Ser Pro 
    1010                 1015                 1020             


Ser Ala  Gln Pro Gly Asp Ser  Ser Leu Arg Leu Gln  Arg Pro Arg 
    1025                 1030                 1035             


Pro Ala  Thr Pro Pro Ser Ser  Pro Lys Arg Gly Ser  Ala Gly Ala 
    1040                 1045                 1050             


Gln Phe  Ala Ile 
    1055         


<210>  29
<211>  1037
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1037)
<223>  mature SorCS1a, isoform 2

<400>  29

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Cys Val  Phe Leu Leu Leu Pro  Ser Tyr Pro 
    1010                 1015                 1020             


Arg Pro  Pro Pro Pro Ser Ser  Phe Cys Gln Val Gln  Lys Gln 
    1025                 1030                 1035         


<210>  30
<211>  1068
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1068)
<223>  mature SorCS1c, isoform 3

<400>  30

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Met Gln  Asn Glu Lys Glu Gln  Glu Leu Ile Asn Pro  Val Ser His 
    1025                 1030                 1035             


Ser Glu  Ser Arg Pro Ser Val  Pro His Pro Asp Leu  Arg Arg Pro 
    1040                 1045                 1050             


Gly Gln  Leu Val Asp Glu Lys  Val Glu Ser Gln Leu  Leu Gly Lys 
    1055                 1060                 1065             


<210>  31
<211>  1068
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1068)
<223>  mature SorCS1c+, isoform 4

<400>  31

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Lys Ile  Pro Gly Ile Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Met Gln  Asn Glu Lys Glu Gln  Glu Leu Ile Asn Pro  Val Ser His 
    1025                 1030                 1035             


Ser Glu  Ser Arg Ser Ser Val  Pro His Pro Asp Leu  Arg Arg Pro 
    1040                 1045                 1050             


Gly Gln  Leu Val Asp Glu Lys  Val Glu Ser Gln Leu  Leu Gly Glu 
    1055                 1060                 1065             


<210>  32
<211>  1081
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1081)
<223>  mature SorCS1d

<400>  32

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met 
            980                 985                 990         


Leu Met Leu Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Val Ile 
        995                 1000                 1005             


Tyr Lys  Phe Lys Arg Gly Trp  Arg Asp Arg Ser Ala  Val Lys Asn 
    1010                 1015                 1020             


Ile Gly  Cys Ser Cys Arg Gly  Pro Gly Phe Asn Ser  Gln His Gln 
    1025                 1030                 1035             


Gln Gly  Gly Ser Gln Ala Ser  Val Thr Ser Val Pro  Arg Asp Pro 
    1040                 1045                 1050             


Ser Pro  Ser Ser Asp Leu His  Gly His Gln Glu His  Thr Trp Cys 
    1055                 1060                 1065             


Thr Asp  Ile His Pro Gly Lys  Thr Pro Ile His Ile  Lys 
    1070                 1075                 1080     


<210>  33
<211>  989
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(989)
<223>  Soluble mature SorCS1

<400>  33

Ser Gly Thr Glu Pro Glu Lys Ile Glu Pro Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Lys Asp Gly Gly Gln Gln Gly Leu Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Gly Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Cys Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Leu Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ser Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Ser Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Ser Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Arg Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Lys Tyr Ala Gly Ala Met Glu Ser Glu 
        595                 600                 605             


Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu 
    610                 615                 620                 


Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Ala 
                645                 650                 655     


Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu 
            660                 665                 670         


Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly 
        675                 680                 685             


Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His 
    690                 695                 700                 


Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr 
705                 710                 715                 720 


Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn 
                725                 730                 735     


Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly 
            740                 745                 750         


Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser 
        755                 760                 765             


Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu 
    770                 775                 780                 


Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala 
785                 790                 795                 800 


Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr 
                805                 810                 815     


Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe 
            820                 825                 830         


Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala 
        835                 840                 845             


Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu 
    850                 855                 860                 


Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn 
865                 870                 875                 880 


Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys 
                885                 890                 895     


Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala 
            900                 905                 910         


Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro Tyr 
        915                 920                 925             


Gln Asp Gly Thr Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu Gln 
    930                 935                 940                 


Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His Phe 
945                 950                 955                 960 


Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr 
                965                 970                 975     


Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly 
            980                 985                 


<210>  34
<211>  1361
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(1361)
<223>  preproSorCS1

<400>  34

Met Thr Gly Arg Phe Pro Pro Arg Asn Arg Lys Leu Pro Thr His Arg 
1               5                   10                  15      


Pro Leu Arg Glu Pro Gly Val Asp Arg Pro Arg Gly Gln Gly Ala Arg 
            20                  25                  30          


Thr Gln Arg Trp Asp Pro Arg Pro Arg Gly Arg Arg Val Gly Gly Gly 
        35                  40                  45              


Glu Arg Arg Gly Glu Ala Ala Ala Ala Pro Ala Arg Pro Arg Gly Ser 
    50                  55                  60                  


Arg Arg Arg Arg Leu Gln Arg Pro Glu Thr Arg Ala Arg Ala Arg Ser 
65                  70                  75                  80  


Ala Ser Asp Phe Ser Ser Ala Pro Pro Pro Arg Gly Gly Gly Ser Leu 
                85                  90                  95      


Arg Pro Asp Pro Arg Ser Ala Gln Ala Gln Pro Gly Arg Ala Ala Ala 
            100                 105                 110         


Thr Cys Pro Ala Pro Pro Pro Pro Ala Pro Thr Ala Ala Gln Leu Gly 
        115                 120                 125             


Trp Ser Trp Gly Pro Glu Arg Arg Pro Pro Thr Ala Ala Ser Ala Glu 
    130                 135                 140                 


Leu Arg Ala Ala Thr Phe Val Leu Gly Pro Leu Ser Pro Leu Leu Phe 
145                 150                 155                 160 


Ala Pro Ala Met Gly Lys Val Gly Ala Gly Gly Gly Ser Gln Ala Arg 
                165                 170                 175     


Leu Ser Ala Leu Leu Ala Gly Ala Gly Leu Leu Val Leu Cys Ala Pro 
            180                 185                 190         


Gly Val Cys Gly Gly Gly Ser Cys Cys Pro Pro Pro His Pro Ser Ser 
        195                 200                 205             


Ala Pro Arg Ser Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg 
    210                 215                 220                 


Pro Gly Arg Ala Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu 
225                 230                 235                 240 


Phe Ser Val Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg 
                245                 250                 255     


Gly Thr Gly Ala Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg 
            260                 265                 270         


Arg Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser 
        275                 280                 285             


Arg Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly 
    290                 295                 300                 


Thr Leu Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu 
305                 310                 315                 320 


Leu Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His 
                325                 330                 335     


Asn Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu 
            340                 345                 350         


Ile Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser 
        355                 360                 365             


Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn 
    370                 375                 380                 


Asp Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro 
385                 390                 395                 400 


Thr Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser 
                405                 410                 415     


Ser Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg 
            420                 425                 430         


Leu Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp 
        435                 440                 445             


Trp Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu 
    450                 455                 460                 


Phe Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg 
465                 470                 475                 480 


Phe Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His 
                485                 490                 495     


Leu Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg 
            500                 505                 510         


Met Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr 
        515                 520                 525             


Ile Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln 
    530                 535                 540                 


Leu Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn 
545                 550                 555                 560 


Ala Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met 
                565                 570                 575     


His Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu 
            580                 585                 590         


Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly 
        595                 600                 605             


Val Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro 
    610                 615                 620                 


Glu Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly 
625                 630                 635                 640 


Met Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile 
                645                 650                 655     


Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr 
            660                 665                 670         


Asp Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu 
        675                 680                 685             


His Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile 
    690                 695                 700                 


Ala Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile 
705                 710                 715                 720 


Gly Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp 
                725                 730                 735     


Ala Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu 
            740                 745                 750         


Tyr Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu 
        755                 760                 765             


Pro Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser 
    770                 775                 780                 


Lys Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly 
785                 790                 795                 800 


Glu Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser 
                805                 810                 815     


His Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe 
            820                 825                 830         


Asp Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser 
        835                 840                 845             


Gln Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg 
    850                 855                 860                 


Lys Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu 
865                 870                 875                 880 


Ser Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly 
                885                 890                 895     


Tyr Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn 
            900                 905                 910         


Pro Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn 
        915                 920                 925             


Ser Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val 
    930                 935                 940                 


Arg Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro 
945                 950                 955                 960 


Arg Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln 
                965                 970                 975     


Gly His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln 
            980                 985                 990         


Arg Thr Leu Ile Gln Val Asp Phe  Gly Asp Gly Ile Ala  Val Ser Tyr 
        995                 1000                 1005             


Val Asn  Leu Ser Ser Met Glu  Asp Gly Ile Lys His  Val Tyr Gln 
    1010                 1015                 1020             


Asn Val  Gly Ile Phe Arg Val  Thr Val Gln Val Asp  Asn Ser Leu 
    1025                 1030                 1035             


Gly Ser  Asp Ser Ala Val Leu  Tyr Leu His Val Thr  Cys Pro Leu 
    1040                 1045                 1050             


Glu His  Val His Leu Ser Leu  Pro Phe Val Thr Thr  Lys Asn Lys 
    1055                 1060                 1065             


Glu Val  Asn Ala Thr Ala Val  Leu Trp Pro Ser Gln  Val Gly Thr 
    1070                 1075                 1080             


Leu Thr  Tyr Val Trp Trp Tyr  Gly Asn Asn Thr Glu  Pro Leu Ile 
    1085                 1090                 1095             


Thr Leu  Glu Gly Ser Ile Ser  Phe Arg Phe Thr Ser  Glu Gly Met 
    1100                 1105                 1110             


Asn Thr  Ile Thr Val Gln Val  Ser Ala Gly Asn Ala  Ile Leu Gln 
    1115                 1120                 1125             


Asp Thr  Lys Thr Ile Ala Val  Tyr Glu Glu Phe Arg  Ser Leu Arg 
    1130                 1135                 1140             


Leu Ser  Phe Ser Pro Asn Leu  Asp Asp Tyr Asn Pro  Asp Ile Pro 
    1145                 1150                 1155             


Glu Trp  Arg Arg Asp Ile Gly  Arg Val Ile Lys Lys  Ser Leu Val 
    1160                 1165                 1170             


Glu Ala  Thr Gly Val Pro Gly  Gln His Ile Leu Val  Ala Val Leu 
    1175                 1180                 1185             


Pro Gly  Leu Pro Thr Thr Ala  Glu Leu Phe Val Leu  Pro Tyr Gln 
    1190                 1195                 1200             


Asp Pro  Ala Gly Glu Asn Lys  Arg Ser Thr Asp Asp  Leu Glu Gln 
    1205                 1210                 1215             


Ile Ser  Glu Leu Leu Ile His  Thr Leu Asn Gln Asn  Ser Val His 
    1220                 1225                 1230             


Phe Glu  Leu Lys Pro Gly Val  Arg Val Leu Val His  Ala Ala His 
    1235                 1240                 1245             


Leu Thr  Ala Ala Pro Leu Val  Asp Leu Thr Pro Thr  His Ser Gly 
    1250                 1255                 1260             


Ser Ala  Met Leu Met Leu Leu  Ser Val Val Phe Val  Gly Leu Ala 
    1265                 1270                 1275             


Val Phe  Val Ile Tyr Lys Phe  Lys Arg Lys Ile Pro  Gly Ile Asn 
    1280                 1285                 1290             


Val Tyr  Ala Gln Met Gln Asn  Glu Lys Glu Gln Glu  Met Ile Ser 
    1295                 1300                 1305             


Pro Val  Ser His Phe Glu Ser  Arg Pro Ser Val Pro  Gln Thr Glu 
    1310                 1315                 1320             


Leu Arg  Arg Pro Gly Gln Leu  Ile Asp Glu Lys Val  Glu Ser Gln 
    1325                 1330                 1335             


Leu Ile  Gly Ser Ile Ser Ile  Val Ala Glu Asn Gln  Ser Thr Lys 
    1340                 1345                 1350             


Glu Ile  Pro Thr Tyr Val Asn  Val 
    1355                 1360     


<210>  35
<211>  1165
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(1165)
<223>  proSorCS1

<400>  35

Gly Gly Ser Cys Cys Pro Pro Pro His Pro Ser Ser Ala Pro Arg Ser 
1               5                   10                  15      


Ala Ser Thr Pro Arg Gly Phe Ser His Gln Gly Arg Pro Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Leu Val Val Arg Pro Leu Phe Ser Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Arg Gly Thr Gly Ala 
    50                  55                  60                  


Ser Met Ala Val Ala Ala Arg Ser Gly Arg Arg Arg Arg Ser Gly Ala 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr Leu Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Ile 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
        675                 680                 685             


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    690                 695                 700                 


Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
705                 710                 715                 720 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                725                 730                 735     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            740                 745                 750         


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
        755                 760                 765             


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    770                 775                 780                 


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
785                 790                 795                 800 


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
                805                 810                 815     


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
            820                 825                 830         


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
        835                 840                 845             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    850                 855                 860                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
865                 870                 875                 880 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
                885                 890                 895     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg Phe 
            900                 905                 910         


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        915                 920                 925             


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
    930                 935                 940                 


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
945                 950                 955                 960 


Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser Leu 
                965                 970                 975     


Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu 
            980                 985                 990         


Pro Gly Leu Pro Thr Thr Ala Glu  Leu Phe Val Leu Pro  Tyr Gln Asp 
        995                 1000                 1005             


Pro Ala  Gly Glu Asn Lys Arg  Ser Thr Asp Asp Leu  Glu Gln Ile 
    1010                 1015                 1020             


Ser Glu  Leu Leu Ile His Thr  Leu Asn Gln Asn Ser  Val His Phe 
    1025                 1030                 1035             


Glu Leu  Lys Pro Gly Val Arg  Val Leu Val His Ala  Ala His Leu 
    1040                 1045                 1050             


Thr Ala  Ala Pro Leu Val Asp  Leu Thr Pro Thr His  Ser Gly Ser 
    1055                 1060                 1065             


Ala Met  Leu Met Leu Leu Ser  Val Val Phe Val Gly  Leu Ala Val 
    1070                 1075                 1080             


Phe Val  Ile Tyr Lys Phe Lys  Arg Lys Ile Pro Gly  Ile Asn Val 
    1085                 1090                 1095             


Tyr Ala  Gln Met Gln Asn Glu  Lys Glu Gln Glu Met  Ile Ser Pro 
    1100                 1105                 1110             


Val Ser  His Phe Glu Ser Arg  Pro Ser Val Pro Gln  Thr Glu Leu 
    1115                 1120                 1125             


Arg Arg  Pro Gly Gln Leu Ile  Asp Glu Lys Val Glu  Ser Gln Leu 
    1130                 1135                 1140             


Ile Gly  Ser Ile Ser Ile Val  Ala Glu Asn Gln Ser  Thr Lys Glu 
    1145                 1150                 1155             


Ile Pro  Thr Tyr Val Asn Val  
    1160                 1165 


<210>  36
<211>  1088
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(1088)
<223>  mature SorCS1

<400>  36

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Leu Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala 
            980                 985                 990         


Met Leu Met Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
        995                 1000                 1005             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Ile Asn  Val Tyr Ala 
    1010                 1015                 1020             


Gln Met  Gln Asn Glu Lys Glu  Gln Glu Met Ile Ser  Pro Val Ser 
    1025                 1030                 1035             


His Phe  Glu Ser Arg Pro Ser  Val Pro Gln Thr Glu  Leu Arg Arg 
    1040                 1045                 1050             


Pro Gly  Gln Leu Ile Asp Glu  Lys Val Glu Ser Gln  Leu Ile Gly 
    1055                 1060                 1065             


Ser Ile  Ser Ile Val Ala Glu  Asn Gln Ser Thr Lys  Glu Ile Pro 
    1070                 1075                 1080             


Thr Tyr  Val Asn Val 
    1085             


<210>  37
<211>  990
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(990)
<223>  soluble SorCS1

<400>  37

Ser Gly Ala Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Ala Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Gly Gly Gln Gln Glu Pro Gly Thr 
            20                  25                  30          


Leu Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly 
            980                 985                 990 


<210>  38
<211>  997
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  MISC_FEATURE
<222>  (1)..(997)
<223>  mature SorCS1

<400>  38

Met Arg Lys Val Ser Glu Ile Met Val Leu Arg Ser Trp His Ser Val 
1               5                   10                  15      


Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr 
            20                  25                  30          


Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys 
        35                  40                  45              


Leu Asn Asp Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val 
    50                  55                  60                  


Cys Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile 
65                  70                  75                  80  


Glu Ser Ser Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys 
                85                  90                  95      


Tyr Arg Leu Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln 
            100                 105                 110         


Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser 
        115                 120                 125             


Ala Glu Phe Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro 
    130                 135                 140                 


Asn Arg Phe Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu 
145                 150                 155                 160 


Val His Leu Glu Ala Arg Thr Val Asp Gly His Ser Gln Tyr Leu Thr 
                165                 170                 175     


Cys Arg Met Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro 
            180                 185                 190         


Gly Tyr Ile Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe 
        195                 200                 205             


Val Gln Leu Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg 
    210                 215                 220                 


Arg Asn Ala Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys 
225                 230                 235                 240 


Asp Met His Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val 
                245                 250                 255     


Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr 
            260                 265                 270         


Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg 
        275                 280                 285             


Gly Pro Glu Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile 
    290                 295                 300                 


Lys Gly Met Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr 
305                 310                 315                 320 


Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro 
                325                 330                 335     


Asp Thr Asp Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys 
            340                 345                 350         


Ser Leu His Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly 
        355                 360                 365             


Ile Ile Ala Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly 
    370                 375                 380                 


Asn Ile Gly Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser 
385                 390                 395                 400 


Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser 
                405                 410                 415     


Val Leu Tyr Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr 
            420                 425                 430         


Ser Leu Pro Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser 
        435                 440                 445             


Trp Ser Lys Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val 
    450                 455                 460                 


Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His 
465                 470                 475                 480 


Phe Ser His Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser 
                485                 490                 495     


Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu 
            500                 505                 510         


His Ser Gln Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys 
        515                 520                 525             


Lys Arg Lys Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala 
    530                 535                 540                 


Met Glu Ser Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp 
545                 550                 555                 560 


Tyr Gly Tyr Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp 
                565                 570                 575     


Phe Asn Pro Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr 
            580                 585                 590         


Leu Asn Ser Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp 
        595                 600                 605             


Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys 
    610                 615                 620                 


Ala Pro Arg Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala 
625                 630                 635                 640 


Glu Gln Gly His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp 
                645                 650                 655     


Val Gln Arg Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val 
            660                 665                 670         


Ser Tyr Val Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr 
        675                 680                 685             


His Asn Val Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu 
    690                 695                 700                 


Gly Ser Asp Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu 
705                 710                 715                 720 


His Val His Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val 
                725                 730                 735     


Asn Ala Thr Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr 
            740                 745                 750         


Val Trp Trp Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly 
        755                 760                 765             


Ser Ile Ser Phe Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val 
    770                 775                 780                 


Gln Val Ser Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala 
785                 790                 795                 800 


Val Tyr Glu Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu 
                805                 810                 815     


Asp Asp Tyr Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg 
            820                 825                 830         


Val Ile Lys Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His 
        835                 840                 845             


Ile Leu Val Ala Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe 
    850                 855                 860                 


Val Leu Pro Tyr Gln Asp Pro Thr Gly Glu Asn Lys Arg Ser Ala Glu 
865                 870                 875                 880 


Asp Leu Glu Gln Ile Ser Glu Leu Leu Ile His Lys Leu Asn Gln Asn 
                885                 890                 895     


Ser Val His Phe Glu Leu Lys Pro Gly Val Gln Ile Leu Val His Ala 
            900                 905                 910         


Ala His Leu Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser 
        915                 920                 925             


Gly Ser Ala Met Leu Met Leu Leu Ser Val Val Phe Val Gly Leu Ala 
    930                 935                 940                 


Val Phe Val Ile Tyr Lys Phe Lys Arg Arg Val Ala Leu Pro Ser Pro 
945                 950                 955                 960 


Pro Ser Pro Ser Thr Gln Pro Gly Asp Ser Ser Leu Arg Leu Gln Arg 
                965                 970                 975     


Ala Arg His Ala Thr Pro Pro Ser Thr Pro Lys Arg Gly Ser Ala Gly 
            980                 985                 990         


Ala Gln Phe Ala Ile 
        995         


<210>  39
<211>  929
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  MISC_FEATURE
<222>  (1)..(929)
<223>  soluble SorCS1

<400>  39

Met Arg Lys Val Ser Glu Ile Met Val Leu Arg Ser Trp His Ser Val 
1               5                   10                  15      


Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr 
            20                  25                  30          


Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys 
        35                  40                  45              


Leu Asn Asp Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val 
    50                  55                  60                  


Cys Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile 
65                  70                  75                  80  


Glu Ser Ser Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys 
                85                  90                  95      


Tyr Arg Leu Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln 
            100                 105                 110         


Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser 
        115                 120                 125             


Ala Glu Phe Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro 
    130                 135                 140                 


Asn Arg Phe Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu 
145                 150                 155                 160 


Val His Leu Glu Ala Arg Thr Val Asp Gly His Ser Gln Tyr Leu Thr 
                165                 170                 175     


Cys Arg Met Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro 
            180                 185                 190         


Gly Tyr Ile Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe 
        195                 200                 205             


Val Gln Leu Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg 
    210                 215                 220                 


Arg Asn Ala Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys 
225                 230                 235                 240 


Asp Met His Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val 
                245                 250                 255     


Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr 
            260                 265                 270         


Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg 
        275                 280                 285             


Gly Pro Glu Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile 
    290                 295                 300                 


Lys Gly Met Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr 
305                 310                 315                 320 


Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro 
                325                 330                 335     


Asp Thr Asp Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys 
            340                 345                 350         


Ser Leu His Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly 
        355                 360                 365             


Ile Ile Ala Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly 
    370                 375                 380                 


Asn Ile Gly Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser 
385                 390                 395                 400 


Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser 
                405                 410                 415     


Val Leu Tyr Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr 
            420                 425                 430         


Ser Leu Pro Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser 
        435                 440                 445             


Trp Ser Lys Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val 
    450                 455                 460                 


Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His 
465                 470                 475                 480 


Phe Ser His Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser 
                485                 490                 495     


Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu 
            500                 505                 510         


His Ser Gln Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys 
        515                 520                 525             


Lys Arg Lys Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala 
    530                 535                 540                 


Met Glu Ser Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp 
545                 550                 555                 560 


Tyr Gly Tyr Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp 
                565                 570                 575     


Phe Asn Pro Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr 
            580                 585                 590         


Leu Asn Ser Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp 
        595                 600                 605             


Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys 
    610                 615                 620                 


Ala Pro Arg Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala 
625                 630                 635                 640 


Glu Gln Gly His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp 
                645                 650                 655     


Val Gln Arg Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val 
            660                 665                 670         


Ser Tyr Val Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr 
        675                 680                 685             


His Asn Val Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu 
    690                 695                 700                 


Gly Ser Asp Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu 
705                 710                 715                 720 


His Val His Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val 
                725                 730                 735     


Asn Ala Thr Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr 
            740                 745                 750         


Val Trp Trp Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly 
        755                 760                 765             


Ser Ile Ser Phe Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val 
    770                 775                 780                 


Gln Val Ser Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala 
785                 790                 795                 800 


Val Tyr Glu Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu 
                805                 810                 815     


Asp Asp Tyr Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg 
            820                 825                 830         


Val Ile Lys Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln His 
        835                 840                 845             


Ile Leu Val Ala Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe 
    850                 855                 860                 


Val Leu Pro Tyr Gln Asp Pro Thr Gly Glu Asn Lys Arg Ser Ala Glu 
865                 870                 875                 880 


Asp Leu Glu Gln Ile Ser Glu Leu Leu Ile His Lys Leu Asn Gln Asn 
                885                 890                 895     


Ser Val His Phe Glu Leu Lys Pro Gly Val Gln Ile Leu Val His Ala 
            900                 905                 910         


Ala His Leu Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser 
        915                 920                 925             


Gly 
    


<210>  40
<211>  1196
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1196)
<223>  preproSorCS1

<400>  40

Met Gly Lys Val Gly Ala Gly Gly Val Ser Pro Ala Gly Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Gly Ala Gly Leu Leu Val Leu Cys Ala Pro Gly Ser Cys 
            20                  25                  30          


Gly Gly Gly Ser Cys Cys Pro Pro Arg His Pro Ser Ala Ala Pro Arg 
        35                  40                  45              


Trp Ala Pro Thr Pro Gly Gly Leu Pro His Gln Gly Pro Arg Gly Arg 
    50                  55                  60                  


Ala Pro Ala Thr Pro Leu Pro Gln Leu Gly Arg Pro Leu Phe Ala Val 
65                  70                  75                  80  


Ala Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Pro Gly Thr Gly 
                85                  90                  95      


Ala Ser Val Ala Val Ala Pro Arg Ser Gly Arg Lys Arg Arg Ser Gly 
            100                 105                 110         


Glu Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Thr Ser Arg Ser Pro 
        115                 120                 125             


Arg Gly Val Leu Arg Asp Arg Gly Gln Leu Glu Pro Gly Thr Leu Glu 
    130                 135                 140                 


Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Leu Glu Glu Leu Lys Leu 
145                 150                 155                 160 


Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala 
                165                 170                 175     


Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr 
            180                 185                 190         


Lys Leu Phe Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp 
        195                 200                 205             


Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val 
    210                 215                 220                 


Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys 
225                 230                 235                 240 


Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu 
                245                 250                 255     


Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe 
            260                 265                 270         


Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu 
        275                 280                 285             


Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg 
    290                 295                 300                 


Arg Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe Tyr Trp 
305                 310                 315                 320 


Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala 
                325                 330                 335     


Arg Thr Val Asp Gly His Ser Gln Tyr Leu Thr Cys Arg Met Gln Asn 
            340                 345                 350         


Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro 
        355                 360                 365             


Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser 
    370                 375                 380                 


Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala 
385                 390                 395                 400 


Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile 
                405                 410                 415     


Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln 
            420                 425                 430         


Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe 
        435                 440                 445             


Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn 
    450                 455                 460                 


Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu 
465                 470                 475                 480 


Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn 
                485                 490                 495     


Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg 
            500                 505                 510         


Gly Asp Pro Val His Cys Val Leu Pro Tyr Cys Ser Leu His Leu His 
        515                 520                 525             


Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg 
    530                 535                 540                 


Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu 
545                 550                 555                 560 


Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn 
                565                 570                 575     


Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp 
            580                 585                 590         


Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg 
        595                 600                 605             


His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser 
    610                 615                 620                 


Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly 
625                 630                 635                 640 


Glu Glu Thr Leu Ile Met Thr Leu Leu Asp His Ser His Ser Asp Trp 
                645                 650                 655     


Leu Val Thr Ala Leu Gln Pro Cys Cys Leu Phe Leu Leu Gly Asn Glu 
            660                 665                 670         


Trp Glu Asp Lys Ile Ala Trp Lys Pro Gln Asp Gln Gly Glu Ala Cys 
        675                 680                 685             


Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys 
    690                 695                 700                 


Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val 
705                 710                 715                 720 


Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser 
                725                 730                 735     


Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser 
            740                 745                 750         


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg 
        755                 760                 765             


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
    770                 775                 780                 


Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile 
785                 790                 795                 800 


Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
                805                 810                 815     


Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln 
            820                 825                 830         


Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser 
        835                 840                 845             


Met Glu Asp Gly Ile Lys His Val Tyr His Asn Val Gly Ile Phe Arg 
    850                 855                 860                 


Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu 
865                 870                 875                 880 


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
                885                 890                 895     


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
            900                 905                 910         


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn 
        915                 920                 925             


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ala Phe Lys Phe Thr 
    930                 935                 940                 


Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala 
945                 950                 955                 960 


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser 
                965                 970                 975     


Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
            980                 985                 990         


Pro Glu Trp Arg Arg Asp Val Ser  Arg Val Ile Lys Lys  Ala Leu Val 
        995                 1000                 1005             


Glu Ala  Thr Gly Val Pro Gly  Gln His Ile Leu Val  Ala Val Leu 
    1010                 1015                 1020             


Pro Gly  Leu Pro Thr Ala Ala  Glu Leu Phe Val Leu  Pro His Gln 
    1025                 1030                 1035             


Asp Pro  Thr Gly Glu Asn Lys  Arg Pro Ala Glu Asp  Leu Glu Gln 
    1040                 1045                 1050             


Ile Ser  Glu Leu Met Ile His  Lys Leu Asn Gln Asn  Ser Val His 
    1055                 1060                 1065             


Phe Glu  Leu Lys Pro Gly Val  Gln Val Leu Val His  Ala Ala His 
    1070                 1075                 1080             


Leu Thr  Ala Ala Pro Leu Val  Asp Leu Thr Pro Thr  His Ser Gly 
    1085                 1090                 1095             


Ser Ala  Met Leu Met Leu Leu  Ser Val Val Phe Val  Gly Leu Ala 
    1100                 1105                 1110             


Val Phe  Val Ile Tyr Lys Phe  Lys Arg Lys Ile Pro  Gly Ile Asn 
    1115                 1120                 1125             


Val Tyr  Ala Gln Met Gln Asn  Glu Lys Glu Gln Glu  Met Val Ser 
    1130                 1135                 1140             


Arg Val  Ser His Pro Glu Ser  Arg Pro Tyr Val Pro  Gln Thr Glu 
    1145                 1150                 1155             


Leu Arg  Arg Pro Gly Gln Leu  Ile Asp Glu Lys Val  Glu Ser Gln 
    1160                 1165                 1170             


Leu Ile  Gly Ser Ile Ser Ile  Val Ala Glu Asn Gln  Ser Thr Lys 
    1175                 1180                 1185             


Glu Ile  Pro Thr Tyr Val Asn  Val 
    1190                 1195     


<210>  41
<211>  1163
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1163)
<223>  proSorCS1

<400>  41

Gly Gly Ser Cys Cys Pro Pro Arg His Pro Ser Ala Ala Pro Arg Trp 
1               5                   10                  15      


Ala Pro Thr Pro Gly Gly Leu Pro His Gln Gly Pro Arg Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Leu Pro Gln Leu Gly Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Ser Leu Glu Arg Ala Pro Gly Thr Gly Ala 
    50                  55                  60                  


Ser Val Ala Val Ala Pro Arg Ser Gly Arg Lys Arg Arg Ser Gly Glu 
65                  70                  75                  80  


Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Thr Ser Arg Ser Pro Arg 
                85                  90                  95      


Gly Val Leu Arg Asp Arg Gly Gln Leu Glu Pro Gly Thr Leu Glu Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Leu Glu Glu Leu Lys Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Phe Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Gln Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Val Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Leu Leu Asp His Ser His Ser Asp Trp Leu 
    610                 615                 620                 


Val Thr Ala Leu Gln Pro Cys Cys Leu Phe Leu Leu Gly Asn Glu Trp 
625                 630                 635                 640 


Glu Asp Lys Ile Ala Trp Lys Pro Gln Asp Gln Gly Glu Ala Cys Ile 
                645                 650                 655     


Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys Cys 
            660                 665                 670         


Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val Cys 
        675                 680                 685             


Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser Asn 
    690                 695                 700                 


Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser Lys 
705                 710                 715                 720 


Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Lys 
                725                 730                 735     


Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr Ala 
            740                 745                 750         


Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile Val 
        755                 760                 765             


Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr Leu 
    770                 775                 780                 


Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile Gln Val 
785                 790                 795                 800 


Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser Ser Met 
                805                 810                 815     


Glu Asp Gly Ile Lys His Val Tyr His Asn Val Gly Ile Phe Arg Val 
            820                 825                 830         


Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val Leu Tyr 
        835                 840                 845             


Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro Phe 
    850                 855                 860                 


Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp Pro 
865                 870                 875                 880 


Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn Asn Thr 
                885                 890                 895     


Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ala Phe Lys Phe Thr Ser 
            900                 905                 910         


Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Ala Ile 
        915                 920                 925             


Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg Ser Leu 
    930                 935                 940                 


Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile Pro 
945                 950                 955                 960 


Glu Trp Arg Arg Asp Val Ser Arg Val Ile Lys Lys Ala Leu Val Glu 
                965                 970                 975     


Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val Leu Pro Gly 
            980                 985                 990         


Leu Pro Thr Ala Ala Glu Leu Phe  Val Leu Pro His Gln  Asp Pro Thr 
        995                 1000                 1005             


Gly Glu  Asn Lys Arg Pro Ala  Glu Asp Leu Glu Gln  Ile Ser Glu 
    1010                 1015                 1020             


Leu Met  Ile His Lys Leu Asn  Gln Asn Ser Val His  Phe Glu Leu 
    1025                 1030                 1035             


Lys Pro  Gly Val Gln Val Leu  Val His Ala Ala His  Leu Thr Ala 
    1040                 1045                 1050             


Ala Pro  Leu Val Asp Leu Thr  Pro Thr His Ser Gly  Ser Ala Met 
    1055                 1060                 1065             


Leu Met  Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
    1070                 1075                 1080             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Ile Asn  Val Tyr Ala 
    1085                 1090                 1095             


Gln Met  Gln Asn Glu Lys Glu  Gln Glu Met Val Ser  Arg Val Ser 
    1100                 1105                 1110             


His Pro  Glu Ser Arg Pro Tyr  Val Pro Gln Thr Glu  Leu Arg Arg 
    1115                 1120                 1125             


Pro Gly  Gln Leu Ile Asp Glu  Lys Val Glu Ser Gln  Leu Ile Gly 
    1130                 1135                 1140             


Ser Ile  Ser Ile Val Ala Glu  Asn Gln Ser Thr Lys  Glu Ile Pro 
    1145                 1150                 1155             


Thr Tyr  Val Asn Val 
    1160             


<210>  42
<211>  1086
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1086)
<223>  mature SorCS1

<400>  42

Ser Gly Glu Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Thr Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Arg Gly Gln Leu Glu Pro Gly Thr 
            20                  25                  30          


Leu Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Leu Glu Glu Leu 
        35                  40                  45              


Lys Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Phe Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Gln Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Val Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Leu Leu Asp His Ser His Ser 
    530                 535                 540                 


Asp Trp Leu Val Thr Ala Leu Gln Pro Cys Cys Leu Phe Leu Leu Gly 
545                 550                 555                 560 


Asn Glu Trp Glu Asp Lys Ile Ala Trp Lys Pro Gln Asp Gln Gly Glu 
                565                 570                 575     


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
            580                 585                 590         


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
        595                 600                 605             


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
    610                 615                 620                 


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
625                 630                 635                 640 


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
                645                 650                 655     


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
            660                 665                 670         


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
        675                 680                 685             


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
    690                 695                 700                 


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
705                 710                 715                 720 


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
                725                 730                 735     


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr His Asn Val Gly Ile 
            740                 745                 750         


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
        755                 760                 765             


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
    770                 775                 780                 


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
785                 790                 795                 800 


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
                805                 810                 815     


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ala Phe Lys 
            820                 825                 830         


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
        835                 840                 845             


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
    850                 855                 860                 


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
865                 870                 875                 880 


Asp Ile Pro Glu Trp Arg Arg Asp Val Ser Arg Val Ile Lys Lys Ala 
                885                 890                 895     


Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val 
            900                 905                 910         


Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro His Gln 
        915                 920                 925             


Asp Pro Thr Gly Glu Asn Lys Arg Pro Ala Glu Asp Leu Glu Gln Ile 
    930                 935                 940                 


Ser Glu Leu Met Ile His Lys Leu Asn Gln Asn Ser Val His Phe Glu 
945                 950                 955                 960 


Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr Ala 
                965                 970                 975     


Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met Leu 
            980                 985                 990         


Met Leu Leu Ser Val Val Phe Val  Gly Leu Ala Val Phe  Val Ile Tyr 
        995                 1000                 1005             


Lys Phe  Lys Arg Lys Ile Pro  Gly Ile Asn Val Tyr  Ala Gln Met 
    1010                 1015                 1020             


Gln Asn  Glu Lys Glu Gln Glu  Met Val Ser Arg Val  Ser His Pro 
    1025                 1030                 1035             


Glu Ser  Arg Pro Tyr Val Pro  Gln Thr Glu Leu Arg  Arg Pro Gly 
    1040                 1045                 1050             


Gln Leu  Ile Asp Glu Lys Val  Glu Ser Gln Leu Ile  Gly Ser Ile 
    1055                 1060                 1065             


Ser Ile  Val Ala Glu Asn Gln  Ser Thr Lys Glu Ile  Pro Thr Tyr 
    1070                 1075                 1080             


Val Asn  Val 
    1085     


<210>  43
<211>  988
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (1)..(988)
<223>  soluble SorCS1

<400>  43

Ser Gly Glu Asp Gln Glu Lys Ala Glu Arg Gly Glu Gly Thr Ser Arg 
1               5                   10                  15      


Ser Pro Arg Gly Val Leu Arg Asp Arg Gly Gln Leu Glu Pro Gly Thr 
            20                  25                  30          


Leu Glu Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Leu Glu Glu Leu 
        35                  40                  45              


Lys Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Phe Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Gln Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Val Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Leu Leu Asp His Ser His Ser 
    530                 535                 540                 


Asp Trp Leu Val Thr Ala Leu Gln Pro Cys Cys Leu Phe Leu Leu Gly 
545                 550                 555                 560 


Asn Glu Trp Glu Asp Lys Ile Ala Trp Lys Pro Gln Asp Gln Gly Glu 
                565                 570                 575     


Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu 
            580                 585                 590         


Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro 
        595                 600                 605             


Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg 
    610                 615                 620                 


His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser 
625                 630                 635                 640 


Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly 
                645                 650                 655     


Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln 
            660                 665                 670         


Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu 
        675                 680                 685             


Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn 
    690                 695                 700                 


Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu 
705                 710                 715                 720 


Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu 
                725                 730                 735     


Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr His Asn Val Gly Ile 
            740                 745                 750         


Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala 
        755                 760                 765             


Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser 
    770                 775                 780                 


Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val 
785                 790                 795                 800 


Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly 
                805                 810                 815     


Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ala Phe Lys 
            820                 825                 830         


Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly 
        835                 840                 845             


Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe 
    850                 855                 860                 


Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro 
865                 870                 875                 880 


Asp Ile Pro Glu Trp Arg Arg Asp Val Ser Arg Val Ile Lys Lys Ala 
                885                 890                 895     


Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val 
            900                 905                 910         


Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro His Gln 
        915                 920                 925             


Asp Pro Thr Gly Glu Asn Lys Arg Pro Ala Glu Asp Leu Glu Gln Ile 
    930                 935                 940                 


Ser Glu Leu Met Ile His Lys Leu Asn Gln Asn Ser Val His Phe Glu 
945                 950                 955                 960 


Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu Thr Ala 
                965                 970                 975     


Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly 
            980                 985             


<210>  44
<211>  1369
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1369)
<223>  preproSorCS1

<400>  44

Met Arg Ala Gln Val Phe Leu Gln Gln Ser Gly Leu Ser Glu Lys Lys 
1               5                   10                  15      


His Thr Asp Gly Ile Pro Thr Val Pro Ser Ile Asn Val Ile Pro Glu 
            20                  25                  30          


Arg Ser Lys Glu Leu Leu Val Pro Arg Gly Arg Val Leu Trp Leu Leu 
        35                  40                  45              


Ala Gly Thr Leu Arg Ser Leu Gly Arg Val Gly Asp Ser Thr Ala Arg 
    50                  55                  60                  


Ala Arg Leu Pro Val His Ser Ala Ala Arg Arg Arg Asp Ala Ala Pro 
65                  70                  75                  80  


Gly Ala Leu Ala Glu Pro Ala Leu Pro Pro Ala Ser Pro Arg Arg Arg 
                85                  90                  95      


Arg Arg Arg Trp Leu Ala Ala Pro Ser Gln Pro Ala Arg Ser Ser Gln 
            100                 105                 110         


Ala Gln Pro Gly Arg Ala Ala Gly Thr Cys Pro Ala Pro Pro Pro Arg 
        115                 120                 125             


Ala Pro Pro Pro Pro Asn Leu Asp Gly Val Val Val Leu Ser Ala His 
    130                 135                 140                 


Pro Ala Ala Val Ser Pro Val Pro Arg Ser Ala Ala Cys Leu Arg Phe 
145                 150                 155                 160 


Gly Thr Pro Ser Pro Leu Leu Ser Ala Pro Glu Met Gly Lys Val Gly 
                165                 170                 175     


Ala Gly Asp Gly Ser Ser Ala Ala Leu Ser Ala Leu Leu Thr Gly Ala 
            180                 185                 190         


Gly Leu Leu Met Leu Leu Ala Pro Gly Ile Cys Ser Ser Leu Ser Cys 
        195                 200                 205             


Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Trp Thr Leu Thr Pro 
    210                 215                 220                 


Arg Gly Phe Ser Tyr Pro Gly Pro Leu Gly Arg Ala Pro Ala Thr Pro 
225                 230                 235                 240 


Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala Pro Gly Asp Arg 
                245                 250                 255     


Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val Ser Val Ala Thr 
            260                 265                 270         


Ala Ser Arg Ser Gly Arg Arg Arg Arg Ser Gly Met Asp Pro Glu Lys 
        275                 280                 285             


Thr Glu Pro Gly Glu Gly Thr Ser Arg Ser Arg Arg Asp Met Leu Arg 
    290                 295                 300                 


Asp Gly Gly Gln Gln Gly Pro Gly Thr Gly Ala Arg Asp Pro Asp Lys 
305                 310                 315                 320 


Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr Ser Thr Thr Phe 
                325                 330                 335     


Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser 
            340                 345                 350         


Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr 
        355                 360                 365             


Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr 
    370                 375                 380                 


Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Ile 
385                 390                 395                 400 


Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg Lys Ile Met Leu 
                405                 410                 415     


Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile Ser Ser Asp Glu 
            420                 425                 430         


Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr Ile Gln Ser Leu 
        435                 440                 445             


Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp 
    450                 455                 460                 


Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg Trp Gln Leu Ile 
465                 470                 475                 480 


Gln Glu Ala Val Val Pro Asn Arg Phe Tyr Trp Ser Val Leu Gly Ser 
                485                 490                 495     


Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg Thr Val Asp Gly 
            500                 505                 510         


His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys Thr Glu Ala Asn 
        515                 520                 525             


Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp Ser Leu Ile Val 
    530                 535                 540                 


Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly Gly Arg Pro His 
545                 550                 555                 560 


Tyr Tyr Val Ser Tyr Arg Arg Asn Pro Phe Ala Gln Met Lys Leu Pro 
                565                 570                 575     


Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser Thr Asp Glu Asn 
            580                 585                 590         


Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn 
        595                 600                 605             


Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu 
    610                 615                 620                 


Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Val Met Ile Asp Leu 
625                 630                 635                 640 


Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala Asn Lys Lys Ile 
                645                 650                 655     


Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp 
            660                 665                 670         


Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly Asp Pro Val His 
        675                 680                 685             


Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu Lys Val Ser Glu 
    690                 695                 700                 


Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp Thr Ala Pro Ser 
705                 710                 715                 720 


Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu Ser Asp Ser Asp 
                725                 730                 735     


Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile 
            740                 745                 750         


Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln Gly Gly Val Leu 
        755                 760                 765             


Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His Leu Trp Leu Ser 
    770                 775                 780                 


Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe Thr Ser Ile Pro 
785                 790                 795                 800 


Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile 
                805                 810                 815     


Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp Gln Leu Val 
            820                 825                 830         


Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp 
        835                 840                 845             


Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala Cys Ile Met Gly 
    850                 855                 860                 


Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg Lys Cys Met Gln 
865                 870                 875                 880 


Gly Thr Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys Val Cys Thr Glu 
                885                 890                 895     


Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Ser Ser Gly Gln 
            900                 905                 910         


Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu Ser Lys Asp Cys 
        915                 920                 925             


Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Lys Val Val 
    930                 935                 940                 


Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro 
945                 950                 955                 960 


Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg Ile Val Thr Ala 
                965                 970                 975     


Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr Leu Met Val 
            980                 985                 990         


Gln Leu Glu Glu Gly Asp Val Gln  Arg Thr Leu Ile Gln  Val Asp Phe 
        995                 1000                 1005             


Gly Asp  Gly Ile Ala Val Ser  Tyr Val Asn Leu Ser  Ser Met Glu 
    1010                 1015                 1020             


Asp Gly  Ile Lys His Val Tyr  Gln Asn Val Gly Ile  Phe Arg Val 
    1025                 1030                 1035             


Thr Val  Gln Val Asp Asn Ser  Leu Gly Ser Asp Ser  Ala Val Leu 
    1040                 1045                 1050             


Tyr Leu  His Val Thr Cys Pro  Leu Glu His Val His  Leu Ser Leu 
    1055                 1060                 1065             


Pro Phe  Val Thr Thr Lys Asn  Lys Glu Val Asn Ala  Thr Ala Val 
    1070                 1075                 1080             


Leu Trp  Pro Ser Gln Val Gly  Thr Leu Thr Tyr Val  Trp Trp Tyr 
    1085                 1090                 1095             


Gly Asn  Asn Thr Glu Pro Leu  Ile Thr Leu Glu Gly  Ser Ile Ser 
    1100                 1105                 1110             


Phe Lys  Phe Thr Ser Glu Gly  Met Asn Thr Ile Thr  Val Gln Val 
    1115                 1120                 1125             


Ser Ala  Gly Asn Ala Ile Leu  Gln Asp Thr Lys Thr  Ile Ala Val 
    1130                 1135                 1140             


Tyr Glu  Glu Phe Arg Ser Leu  Arg Leu Ala Phe Ser  Pro Asn Leu 
    1145                 1150                 1155             


Asp Asp  Tyr Asn Pro Asp Ile  Pro Glu Trp Arg Arg  Asp Ile Ser 
    1160                 1165                 1170             


Arg Val  Ile Lys Lys Ser Leu  Val Glu Ala Thr Gly  Ile Pro Ser 
    1175                 1180                 1185             


Gln His  Ile Leu Val Ala Val  Leu Pro Gly Leu Pro  Thr Ala Ala 
    1190                 1195                 1200             


Glu Leu  Phe Val Leu Pro Tyr  Gln Asp Gly Ala Arg  Glu Asn Lys 
    1205                 1210                 1215             


Arg Ser  Pro Glu Asp Leu Glu  Gln Ile Ser Glu Val  Leu Ile His 
    1220                 1225                 1230             


Lys Leu  Asn Gln Asn Leu Val  His Phe Glu Leu Lys  Pro Gly Val 
    1235                 1240                 1245             


Gln Val  Leu Val His Ala Ala  His Leu Thr Ala Ala  Pro Leu Val 
    1250                 1255                 1260             


Asp Leu  Thr Pro Thr His Ser  Gly Ser Ala Met Leu  Met Leu Leu 
    1265                 1270                 1275             


Ser Val  Val Phe Val Gly Leu  Ala Val Phe Val Ile  Tyr Lys Phe 
    1280                 1285                 1290             


Lys Arg  Lys Ile Pro Gly Ile  Asn Val Tyr Ala Gln  Met Gln Asn 
    1295                 1300                 1305             


Glu Lys  Glu Gln Glu Leu Ile  Asn Pro Val Ser His  Thr Glu Ser 
    1310                 1315                 1320             


Arg Pro  Thr Ala Pro His Pro  Asp Leu Arg Arg Pro  Gly Gln Leu 
    1325                 1330                 1335             


Val Asp  Glu Lys Val Glu Ser  His Leu Leu Gly Ser  Ile Ser Ile 
    1340                 1345                 1350             


Val Ala  Glu Asn Gln Ser Thr  Lys Glu Ile Pro Thr  Tyr Val Asn 
    1355                 1360                 1365             


Val 
    


<210>  45
<211>  1165
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1165)
<223>  proSorCS1

<400>  45

Ser Leu Ser Cys Cys Pro Pro Gln His Pro Ser Ser Thr Pro Arg Trp 
1               5                   10                  15      


Thr Leu Thr Pro Arg Gly Phe Ser Tyr Pro Gly Pro Leu Gly Arg Ala 
            20                  25                  30          


Pro Ala Thr Pro Pro Pro Leu Phe Met Arg Pro Leu Phe Ala Val Ala 
        35                  40                  45              


Pro Gly Asp Arg Ala Leu Phe Leu Glu Arg Ala Gly Gly Ser Arg Val 
    50                  55                  60                  


Ser Val Ala Thr Ala Ser Arg Ser Gly Arg Arg Arg Arg Ser Gly Met 
65                  70                  75                  80  


Asp Pro Glu Lys Thr Glu Pro Gly Glu Gly Thr Ser Arg Ser Arg Arg 
                85                  90                  95      


Asp Met Leu Arg Asp Gly Gly Gln Gln Gly Pro Gly Thr Gly Ala Arg 
            100                 105                 110         


Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu Arg Leu Thr 
        115                 120                 125             


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    130                 135                 140                 


Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
145                 150                 155                 160 


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                165                 170                 175     


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val Gly 
            180                 185                 190         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        195                 200                 205             


Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu Ile 
    210                 215                 220                 


Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                245                 250                 255     


Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg Arg 
            260                 265                 270         


Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe Tyr Trp Ser 
        275                 280                 285             


Val Leu Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala Arg 
    290                 295                 300                 


Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met Gln Asn Cys 
305                 310                 315                 320 


Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile Asp Pro Asp 
                325                 330                 335     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            340                 345                 350         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Pro Phe Ala Gln 
        355                 360                 365             


Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile Ser 
    370                 375                 380                 


Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
385                 390                 395                 400 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                405                 410                 415     


Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn Val 
            420                 425                 430         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        435                 440                 445             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    450                 455                 460                 


Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp Leu Arg Gly 
465                 470                 475                 480 


Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                485                 490                 495     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Arg Asp 
            500                 505                 510         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu Leu 
        515                 520                 525             


Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    530                 535                 540                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr Leu Asp Gln 
545                 550                 555                 560 


Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg His 
                565                 570                 575     


Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser Phe 
            580                 585                 590         


Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly Glu 
        595                 600                 605             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    610                 615                 620                 


Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
625                 630                 635                 640 


Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu Ala 
                645                 650                 655     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu Arg 
            660                 665                 670         


Lys Cys Met Gln Gly Thr Tyr Ala Gly Ala Met Glu Ser Glu Pro Cys 
        675                 680                 685             


Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    690                 695                 700                 


Ser Ser Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser Leu 
705                 710                 715                 720 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                725                 730                 735     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            740                 745                 750         


Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu Arg 
        755                 760                 765             


Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    770                 775                 780                 


Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu Ile 
785                 790                 795                 800 


Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu Ser 
                805                 810                 815     


Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile Phe 
            820                 825                 830         


Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala Val 
        835                 840                 845             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    850                 855                 860                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
865                 870                 875                 880 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly Asn 
                885                 890                 895     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Lys Phe 
            900                 905                 910         


Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        915                 920                 925             


Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe Arg 
    930                 935                 940                 


Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
945                 950                 955                 960 


Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys Lys Ser Leu 
                965                 970                 975     


Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val Ala Val Leu 
            980                 985                 990         


Pro Gly Leu Pro Thr Ala Ala Glu  Leu Phe Val Leu Pro  Tyr Gln Asp 
        995                 1000                 1005             


Gly Ala  Arg Glu Asn Lys Arg  Ser Pro Glu Asp Leu  Glu Gln Ile 
    1010                 1015                 1020             


Ser Glu  Val Leu Ile His Lys  Leu Asn Gln Asn Leu  Val His Phe 
    1025                 1030                 1035             


Glu Leu  Lys Pro Gly Val Gln  Val Leu Val His Ala  Ala His Leu 
    1040                 1045                 1050             


Thr Ala  Ala Pro Leu Val Asp  Leu Thr Pro Thr His  Ser Gly Ser 
    1055                 1060                 1065             


Ala Met  Leu Met Leu Leu Ser  Val Val Phe Val Gly  Leu Ala Val 
    1070                 1075                 1080             


Phe Val  Ile Tyr Lys Phe Lys  Arg Lys Ile Pro Gly  Ile Asn Val 
    1085                 1090                 1095             


Tyr Ala  Gln Met Gln Asn Glu  Lys Glu Gln Glu Leu  Ile Asn Pro 
    1100                 1105                 1110             


Val Ser  His Thr Glu Ser Arg  Pro Thr Ala Pro His  Pro Asp Leu 
    1115                 1120                 1125             


Arg Arg  Pro Gly Gln Leu Val  Asp Glu Lys Val Glu  Ser His Leu 
    1130                 1135                 1140             


Leu Gly  Ser Ile Ser Ile Val  Ala Glu Asn Gln Ser  Thr Lys Glu 
    1145                 1150                 1155             


Ile Pro  Thr Tyr Val Asn Val  
    1160                 1165 


<210>  46
<211>  1088
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1088)
<223>  mature SorCS1

<400>  46

Ser Gly Met Asp Pro Glu Lys Thr Glu Pro Gly Glu Gly Thr Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Arg Asp Gly Gly Gln Gln Gly Pro Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Leu Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Thr Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Ser Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Gly Ala Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala 
            980                 985                 990         


Met Leu Met Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
        995                 1000                 1005             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Ile Asn  Val Tyr Ala 
    1010                 1015                 1020             


Gln Met  Gln Asn Glu Lys Glu  Gln Glu Leu Ile Asn  Pro Val Ser 
    1025                 1030                 1035             


His Thr  Glu Ser Arg Pro Thr  Ala Pro His Pro Asp  Leu Arg Arg 
    1040                 1045                 1050             


Pro Gly  Gln Leu Val Asp Glu  Lys Val Glu Ser His  Leu Leu Gly 
    1055                 1060                 1065             


Ser Ile  Ser Ile Val Ala Glu  Asn Gln Ser Thr Lys  Glu Ile Pro 
    1070                 1075                 1080             


Thr Tyr  Val Asn Val 
    1085             


<210>  47
<211>  990
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(990)
<223>  soluble SorCS1

<400>  47

Ser Gly Met Asp Pro Glu Lys Thr Glu Pro Gly Glu Gly Thr Ser Arg 
1               5                   10                  15      


Ser Arg Arg Asp Met Leu Arg Asp Gly Gly Gln Gln Gly Pro Gly Thr 
            20                  25                  30          


Gly Ala Arg Asp Pro Asp Lys Ala Thr Arg Phe Arg Met Glu Glu Leu 
        35                  40                  45              


Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn 
    50                  55                  60                  


Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile 
65                  70                  75                  80  


Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser 
                85                  90                  95      


Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp 
            100                 105                 110         


Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr 
        115                 120                 125             


Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser 
    130                 135                 140                 


Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu 
145                 150                 155                 160 


Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp 
                165                 170                 175     


Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe 
            180                 185                 190         


Gly Arg Arg Trp Gln Leu Ile Gln Glu Ala Val Val Pro Asn Arg Phe 
        195                 200                 205             


Tyr Trp Ser Val Leu Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu 
    210                 215                 220                 


Glu Ala Arg Thr Val Asp Gly His Ser Ile Tyr Leu Thr Cys Arg Met 
225                 230                 235                 240 


Gln Asn Cys Thr Glu Ala Asn Arg Asn Lys Pro Phe Pro Gly Tyr Ile 
                245                 250                 255     


Asp Pro Asp Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu 
            260                 265                 270         


Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Pro 
        275                 280                 285             


Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His 
    290                 295                 300                 


Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp 
305                 310                 315                 320 


Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val 
                325                 330                 335     


Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu 
            340                 345                 350         


Gly Asn Val Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met 
        355                 360                 365             


Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr 
    370                 375                 380                 


Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Ala Asp 
385                 390                 395                 400 


Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His 
                405                 410                 415     


Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala 
            420                 425                 430         


Ser Arg Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly 
        435                 440                 445             


Ser Glu Leu Ser Asp Ser Asp Ile Ser Met Phe Val Ser Ser Asp Ala 
    450                 455                 460                 


Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Ile Leu Tyr 
465                 470                 475                 480 


Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro 
                485                 490                 495     


Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys 
            500                 505                 510         


Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu 
        515                 520                 525             


Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His 
    530                 535                 540                 


Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp 
545                 550                 555                 560 


Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln 
                565                 570                 575     


Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys 
            580                 585                 590         


Ser Glu Arg Lys Cys Met Gln Gly Thr Tyr Ala Gly Ala Met Glu Ser 
        595                 600                 605             


Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr 
    610                 615                 620                 


Glu Arg His Ser Ser Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser 
                645                 650                 655     


Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg 
            660                 665                 670         


Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg 
        675                 680                 685             


Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly 
    690                 695                 700                 


His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg 
705                 710                 715                 720 


Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val 
                725                 730                 735     


Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val 
            740                 745                 750         


Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp 
        755                 760                 765             


Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His 
    770                 775                 780                 


Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr 
785                 790                 795                 800 


Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp 
                805                 810                 815     


Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser 
            820                 825                 830         


Phe Lys Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser 
        835                 840                 845             


Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu 
    850                 855                 860                 


Glu Phe Arg Ser Leu Arg Leu Ala Phe Ser Pro Asn Leu Asp Asp Tyr 
865                 870                 875                 880 


Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Ile Lys 
                885                 890                 895     


Lys Ser Leu Val Glu Ala Thr Gly Ile Pro Ser Gln His Ile Leu Val 
            900                 905                 910         


Ala Val Leu Pro Gly Leu Pro Thr Ala Ala Glu Leu Phe Val Leu Pro 
        915                 920                 925             


Tyr Gln Asp Gly Ala Arg Glu Asn Lys Arg Ser Pro Glu Asp Leu Glu 
    930                 935                 940                 


Gln Ile Ser Glu Val Leu Ile His Lys Leu Asn Gln Asn Leu Val His 
945                 950                 955                 960 


Phe Glu Leu Lys Pro Gly Val Gln Val Leu Val His Ala Ala His Leu 
                965                 970                 975     


Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly 
            980                 985                 990 


<210>  48
<211>  1258
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1258)
<223>  preproSorCS1

<400>  48

Met Glu Lys Val Ala Gly Trp Tyr Pro Ala Trp His Val Ala Leu Leu 
1               5                   10                  15      


Tyr Trp Thr Trp Leu Phe Leu Phe Thr Phe Gly Phe Thr Gly Ala Glu 
            20                  25                  30          


Ile Thr Cys Arg Ser Cys His Ser Gln Val Asn Pro Gln Gln Gln His 
        35                  40                  45              


Pro Gln Gln Gly Leu Pro Met His Leu Lys Thr Asp Arg Gly Glu Lys 
    50                  55                  60                  


Glu Arg Trp Arg Ile Pro Gly Glu Gln Gly Gly Glu Arg Gly Arg Gly 
65                  70                  75                  80  


Ala Gly Met Asp Thr Glu Asp Ala Glu Leu Gln Ala Pro Phe Asp Pro 
                85                  90                  95      


Ala Leu Ala Gly Thr Lys Phe Ser Gly Trp Glu Thr Arg Ser Trp Ala 
            100                 105                 110         


Ser Glu Pro Glu Lys Ala Pro Gly Asp Ser Arg Pro Gly Ala Ala Ala 
        115                 120                 125             


Ala Pro Thr Gly Glu Tyr Pro Gln Arg Gly Gln Ala Gly Gly Arg Arg 
    130                 135                 140                 


Asn Ser Ala Arg Arg Arg Arg Gly Arg Ser Pro Arg Gly Thr Ala Gly 
145                 150                 155                 160 


Pro Gly Gly Ala Ala Gly Arg Glu Pro Gly Gly Ser Gly Ala Ala Arg 
                165                 170                 175     


Phe Gly Leu Glu Glu Leu Arg Leu Gly Ser Thr Thr Phe Ala Leu Thr 
            180                 185                 190         


Gly Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly Gln Asn 
        195                 200                 205             


Ser Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly 
    210                 215                 220                 


Ser Ile Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr 
225                 230                 235                 240 


Tyr Glu Lys Leu Asn Asp Lys Ile Gly Leu Lys Thr Ile Leu Ser Tyr 
                245                 250                 255     


Leu Tyr Val Cys Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Thr Asp 
            260                 265                 270         


Pro Glu Val Glu Ser Ser Leu Leu Ile Ser Thr Asp Glu Gly Ala Thr 
        275                 280                 285             


Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr Ile His Ser Leu Leu Phe His 
    290                 295                 300                 


Pro Lys Gln Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu 
305                 310                 315                 320 


Phe Ser Ser Val Glu Phe Gly Arg Arg Trp Leu Leu Leu His Glu Gly 
                325                 330                 335     


Val Ala Pro Asn Arg Phe Tyr Trp Ser Met Met Val Ser Gly Arg Glu 
            340                 345                 350         


Pro Asp Leu Val His Leu Glu Ala Lys Thr Val Asp Gly His Ala Gln 
        355                 360                 365             


Tyr Ile Thr Cys Lys Met Gln Asn Cys Ser Glu Ala Ser Gln Asn Lys 
    370                 375                 380                 


Pro Phe Pro Gly Tyr Ile Asp His Asn Ser Leu Ile Val Gln Asp Asp 
385                 390                 395                 400 


Tyr Val Phe Val Gln Leu Thr Ser Gly Gly Arg Pro His Tyr Tyr Val 
                405                 410                 415     


Ser Tyr Arg Arg Asn Ala Phe Thr Pro Ile Lys Leu Pro Lys Tyr Ser 
            420                 425                 430         


Leu Pro Lys Asp Met His Val Ile Ser Thr Asp Glu Ser Gln Val Phe 
        435                 440                 445             


Ala Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile 
    450                 455                 460                 


Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu Asn Val Lys 
465                 470                 475                 480 


Ser Ser Gln Gly Leu Asp Gly Asn Val Met Ile Asp Leu Tyr Glu Val 
                485                 490                 495     


Ala Gly Ile Lys Gly Met Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln 
            500                 505                 510         


Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp Asn Leu Leu 
        515                 520                 525             


Gln Ala Pro Asp Thr Asp Leu Lys Gly Asn Pro Val His Cys Leu Leu 
    530                 535                 540                 


Pro Tyr Cys Ser Leu His Leu His Leu Lys Val Ser Glu Asn Pro Tyr 
545                 550                 555                 560 


Thr Ser Gly Asn Ile Ala Ser Arg Asp Thr Ala Pro Ser Ile Ile Val 
                565                 570                 575     


Ala Ser Gly Asn Ile Gly Pro Glu Leu Ser Asp Asn Asp Ile Ser Met 
            580                 585                 590         


Phe Val Ser Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu 
        595                 600                 605             


Glu His Ser Val Leu Tyr Leu Asp Gln Gly Gly Val Leu Val Ala Ile 
    610                 615                 620                 


Lys His Thr Ser Leu Pro Ile Arg His Leu Trp Leu Ser Phe Asp Glu 
625                 630                 635                 640 


Gly Lys Ser Trp Ser Lys Tyr Ser Phe Thr Ser Leu Pro Leu Phe Val 
                645                 650                 655     


Asp Gly Ile Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile Met Thr Val 
            660                 665                 670         


Phe Gly His Phe Ser His Arg Ser Glu Trp Gln Leu Val Lys Ile Asp 
        675                 680                 685             


Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp Tyr Trp Thr 
    690                 695                 700                 


Trp Gln Leu His Ser Gln Gly Glu Ala Cys Ile Met Gly Ala Lys Arg 
705                 710                 715                 720 


Ile Tyr Arg Lys Arg Lys Ser Glu Lys Lys Cys Met Gln Gly Lys Tyr 
                725                 730                 735     


Ala Gly Ala Met Thr Ser Glu Pro Cys Val Cys Thr Asp Ala Asp Phe 
            740                 745                 750         


Asp Cys Asp Tyr Gly Tyr Glu Arg His Arg Asn Gly Gln Cys Leu Pro 
        755                 760                 765             


Ala Phe Trp Tyr Asn Pro Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly 
    770                 775                 780                 


Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Lys Val Val Ser Asn Asn 
785                 790                 795                 800 


Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro Gln Gln Cys 
                805                 810                 815     


Pro Gly Lys Ala Pro Gln Gly Leu Arg Ile Ile Thr Ser Asp Gly Lys 
            820                 825                 830         


Leu Thr Ala Glu Gln Gly His Asn Val Thr Phe Leu Val Gln Leu Glu 
        835                 840                 845             


Glu Gly Asp Leu Gln Arg Ser Leu Ile Gln Val Asp Phe Gly Asp Gly 
    850                 855                 860                 


Thr Ala Val Ser Tyr Ala Asn Leu Ser Ser Thr Glu Asp Gly Ile Lys 
865                 870                 875                 880 


His Thr Tyr Gln Asn Val Gly Ile Phe Arg Val Thr Val Leu Val Glu 
                885                 890                 895     


Asn Ser Leu Gly Ser Asp Asn Ala Val Leu Tyr Leu His Val Thr Cys 
            900                 905                 910         


Pro Leu Glu His Val His Leu Ser Leu Pro Phe Val Thr Thr Lys Asn 
        915                 920                 925             


Lys Glu Val Asn Ala Thr Ala Val Leu Trp Pro Ser Gln Val Gly Thr 
    930                 935                 940                 


Leu Thr Tyr Val Trp Trp Phe Gly Asn Asn Thr Glu Pro Leu Ile Thr 
945                 950                 955                 960 


Leu Glu Gly Ser Ile Thr Phe Thr Phe Ser Val Glu Gly Met Asn Thr 
                965                 970                 975     


Ile Thr Val Gln Val Ser Ala Gly Asn Thr Ile Leu Gln Asp Thr Lys 
            980                 985                 990         


Thr Ile Ala Val Tyr Glu Gln Phe  Arg Ser Leu Arg Leu  Ser Phe Ser 
        995                 1000                 1005             


Pro Asn  Leu Asp Asp Tyr Asn  Pro Asp Ile Pro Glu  Trp Arg Arg 
    1010                 1015                 1020             


Asp Ile  Ser Arg Val Val Lys  Arg Ala Leu Val Glu  Ala Thr Gly 
    1025                 1030                 1035             


Ile Ser  Ser Lys His Ile Leu  Val Ala Val Leu Pro  Gly Leu Pro 
    1040                 1045                 1050             


Thr Ser  Ala Glu Leu Phe Ile  Leu Pro Tyr Gln Asp  Ala Thr Gly 
    1055                 1060                 1065             


Gly Asn  Lys Arg Thr Glu Asp  Leu Glu Gln Ile Ser  Glu Ile Leu 
    1070                 1075                 1080             


Ile Gln  Lys Leu Asn Gln Asn  Phe Val His Phe Glu  Leu Lys Pro 
    1085                 1090                 1095             


Gly Val  Arg Val Leu Val His  Ala Ala His Leu Thr  Ala Ala Pro 
    1100                 1105                 1110             


Leu Val  Asp Leu Thr Pro Ser  His Ser Gly Ser Ala  Met Leu Met 
    1115                 1120                 1125             


Leu Leu  Ser Val Val Phe Val  Gly Leu Ala Val Phe  Val Ile Tyr 
    1130                 1135                 1140             


Lys Phe  Lys Arg Lys Ile Pro  Gly Leu Asn Ile Tyr  Ala Gln Met 
    1145                 1150                 1155             


Gln Asn  Glu Lys Asp Gln Glu  Met Val Ser Pro Val  Ser Gln Arg 
    1160                 1165                 1170             


Glu Ser  Ile Pro Asn Val Pro  Gln Ser Glu Leu Met  Ser Pro Glu 
    1175                 1180                 1185             


Gln Leu  Val Asp Glu Lys Leu  Asp Val Gln Pro Ile  Glu Gln Pro 
    1190                 1195                 1200             


Gln Ala  Thr Val Gln Asn Pro  Arg Lys Gly Asn Ala  Ala Lys Val 
    1205                 1210                 1215             


Val Trp  Thr Glu Asp Phe Gln  Lys Ala Cys Gly Ser  Pro Arg Gly 
    1220                 1225                 1230             


Phe Lys  Pro Arg Pro Gly Ala  Glu Val Phe Pro Gln  Leu Leu Ser 
    1235                 1240                 1245             


Pro Arg  Ala Gln Lys Lys Ser  Leu Pro Met 
    1250                 1255             


<210>  49
<211>  1200
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1200)
<223>  proSorCS1

<400>  49

Thr Asp Arg Gly Glu Lys Glu Arg Trp Arg Ile Pro Gly Glu Gln Gly 
1               5                   10                  15      


Gly Glu Arg Gly Arg Gly Ala Gly Met Asp Thr Glu Asp Ala Glu Leu 
            20                  25                  30          


Gln Ala Pro Phe Asp Pro Ala Leu Ala Gly Thr Lys Phe Ser Gly Trp 
        35                  40                  45              


Glu Thr Arg Ser Trp Ala Ser Glu Pro Glu Lys Ala Pro Gly Asp Ser 
    50                  55                  60                  


Arg Pro Gly Ala Ala Ala Ala Pro Thr Gly Glu Tyr Pro Gln Arg Gly 
65                  70                  75                  80  


Gln Ala Gly Gly Arg Arg Asn Ser Ala Arg Arg Arg Arg Gly Arg Ser 
                85                  90                  95      


Pro Arg Gly Thr Ala Gly Pro Gly Gly Ala Ala Gly Arg Glu Pro Gly 
            100                 105                 110         


Gly Ser Gly Ala Ala Arg Phe Gly Leu Glu Glu Leu Arg Leu Gly Ser 
        115                 120                 125             


Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met Val 
    130                 135                 140                 


His Trp Ser Gly Gln Asn Ser Ser Val Ile Leu Ile Leu Thr Lys Leu 
145                 150                 155                 160 


Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg Ser 
                165                 170                 175     


Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Ile Gly Leu 
            180                 185                 190         


Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg Lys 
        195                 200                 205             


Ile Met Leu Leu Thr Asp Pro Glu Val Glu Ser Ser Leu Leu Ile Ser 
    210                 215                 220                 


Thr Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr Ile 
225                 230                 235                 240 


His Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala Tyr 
                245                 250                 255     


Ser Gln Asp Gln Lys Leu Phe Ser Ser Val Glu Phe Gly Arg Arg Trp 
            260                 265                 270         


Leu Leu Leu His Glu Gly Val Ala Pro Asn Arg Phe Tyr Trp Ser Met 
        275                 280                 285             


Met Val Ser Gly Arg Glu Pro Asp Leu Val His Leu Glu Ala Lys Thr 
    290                 295                 300                 


Val Asp Gly His Ala Gln Tyr Ile Thr Cys Lys Met Gln Asn Cys Ser 
305                 310                 315                 320 


Glu Ala Ser Gln Asn Lys Pro Phe Pro Gly Tyr Ile Asp His Asn Ser 
                325                 330                 335     


Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly Gly 
            340                 345                 350         


Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Thr Pro Ile 
        355                 360                 365             


Lys Leu Pro Lys Tyr Ser Leu Pro Lys Asp Met His Val Ile Ser Thr 
    370                 375                 380                 


Asp Glu Ser Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn Asp 
385                 390                 395                 400 


Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr Leu 
                405                 410                 415     


Ala Leu Glu Asn Val Lys Ser Ser Gln Gly Leu Asp Gly Asn Val Met 
            420                 425                 430         


Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala Asn 
        435                 440                 445             


Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys Gly 
    450                 455                 460                 


Arg Asp Trp Asn Leu Leu Gln Ala Pro Asp Thr Asp Leu Lys Gly Asn 
465                 470                 475                 480 


Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu Lys 
                485                 490                 495     


Val Ser Glu Asn Pro Tyr Thr Ser Gly Asn Ile Ala Ser Arg Asp Thr 
            500                 505                 510         


Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Pro Glu Leu Ser 
        515                 520                 525             


Asp Asn Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr Trp 
    530                 535                 540                 


Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln Gly 
545                 550                 555                 560 


Gly Val Leu Val Ala Ile Lys His Thr Ser Leu Pro Ile Arg His Leu 
                565                 570                 575     


Trp Leu Ser Phe Asp Glu Gly Lys Ser Trp Ser Lys Tyr Ser Phe Thr 
            580                 585                 590         


Ser Leu Pro Leu Phe Val Asp Gly Ile Leu Gly Glu Pro Gly Glu Glu 
        595                 600                 605             


Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu Trp 
    610                 615                 620                 


Gln Leu Val Lys Ile Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys Ala 
625                 630                 635                 640 


Glu Glu Asp Tyr Trp Thr Trp Gln Leu His Ser Gln Gly Glu Ala Cys 
                645                 650                 655     


Ile Met Gly Ala Lys Arg Ile Tyr Arg Lys Arg Lys Ser Glu Lys Lys 
            660                 665                 670         


Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Thr Ser Glu Pro Cys Val 
        675                 680                 685             


Cys Thr Asp Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His Arg 
    690                 695                 700                 


Asn Gly Gln Cys Leu Pro Ala Phe Trp Tyr Asn Pro Ser Ser Leu Ser 
705                 710                 715                 720 


Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg 
                725                 730                 735     


Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr Thr 
            740                 745                 750         


Ala Lys Pro Gln Gln Cys Pro Gly Lys Ala Pro Gln Gly Leu Arg Ile 
        755                 760                 765             


Ile Thr Ser Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val Thr 
    770                 775                 780                 


Phe Leu Val Gln Leu Glu Glu Gly Asp Leu Gln Arg Ser Leu Ile Gln 
785                 790                 795                 800 


Val Asp Phe Gly Asp Gly Thr Ala Val Ser Tyr Ala Asn Leu Ser Ser 
                805                 810                 815     


Thr Glu Asp Gly Ile Lys His Thr Tyr Gln Asn Val Gly Ile Phe Arg 
            820                 825                 830         


Val Thr Val Leu Val Glu Asn Ser Leu Gly Ser Asp Asn Ala Val Leu 
        835                 840                 845             


Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu Pro 
    850                 855                 860                 


Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu Trp 
865                 870                 875                 880 


Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Phe Gly Asn Asn 
                885                 890                 895     


Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Thr Phe Thr Phe Ser 
            900                 905                 910         


Val Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn Thr 
        915                 920                 925             


Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Gln Phe Arg Ser 
    930                 935                 940                 


Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp Ile 
945                 950                 955                 960 


Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Val Lys Arg Ala Leu Val 
                965                 970                 975     


Glu Ala Thr Gly Ile Ser Ser Lys His Ile Leu Val Ala Val Leu Pro 
            980                 985                 990         


Gly Leu Pro Thr Ser Ala Glu Leu  Phe Ile Leu Pro Tyr  Gln Asp Ala 
        995                 1000                 1005             


Thr Gly  Gly Asn Lys Arg Thr  Glu Asp Leu Glu Gln  Ile Ser Glu 
    1010                 1015                 1020             


Ile Leu  Ile Gln Lys Leu Asn  Gln Asn Phe Val His  Phe Glu Leu 
    1025                 1030                 1035             


Lys Pro  Gly Val Arg Val Leu  Val His Ala Ala His  Leu Thr Ala 
    1040                 1045                 1050             


Ala Pro  Leu Val Asp Leu Thr  Pro Ser His Ser Gly  Ser Ala Met 
    1055                 1060                 1065             


Leu Met  Leu Leu Ser Val Val  Phe Val Gly Leu Ala  Val Phe Val 
    1070                 1075                 1080             


Ile Tyr  Lys Phe Lys Arg Lys  Ile Pro Gly Leu Asn  Ile Tyr Ala 
    1085                 1090                 1095             


Gln Met  Gln Asn Glu Lys Asp  Gln Glu Met Val Ser  Pro Val Ser 
    1100                 1105                 1110             


Gln Arg  Glu Ser Ile Pro Asn  Val Pro Gln Ser Glu  Leu Met Ser 
    1115                 1120                 1125             


Pro Glu  Gln Leu Val Asp Glu  Lys Leu Asp Val Gln  Pro Ile Glu 
    1130                 1135                 1140             


Gln Pro  Gln Ala Thr Val Gln  Asn Pro Arg Lys Gly  Asn Ala Ala 
    1145                 1150                 1155             


Lys Val  Val Trp Thr Glu Asp  Phe Gln Lys Ala Cys  Gly Ser Pro 
    1160                 1165                 1170             


Arg Gly  Phe Lys Pro Arg Pro  Gly Ala Glu Val Phe  Pro Gln Leu 
    1175                 1180                 1185             


Leu Ser  Pro Arg Ala Gln Lys  Lys Ser Leu Pro Met  
    1190                 1195                 1200 


<210>  50
<211>  1121
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1121)
<223>  mature SorCS1

<400>  50

Gly Gln Ala Gly Gly Arg Arg Asn Ser Ala Arg Arg Arg Arg Gly Arg 
1               5                   10                  15      


Ser Pro Arg Gly Thr Ala Gly Pro Gly Gly Ala Ala Gly Arg Glu Pro 
            20                  25                  30          


Gly Gly Ser Gly Ala Ala Arg Phe Gly Leu Glu Glu Leu Arg Leu Gly 
        35                  40                  45              


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    50                  55                  60                  


Val His Trp Ser Gly Gln Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
65                  70                  75                  80  


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                85                  90                  95      


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Ile Gly 
            100                 105                 110         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        115                 120                 125             


Lys Ile Met Leu Leu Thr Asp Pro Glu Val Glu Ser Ser Leu Leu Ile 
    130                 135                 140                 


Ser Thr Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
145                 150                 155                 160 


Ile His Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                165                 170                 175     


Tyr Ser Gln Asp Gln Lys Leu Phe Ser Ser Val Glu Phe Gly Arg Arg 
            180                 185                 190         


Trp Leu Leu Leu His Glu Gly Val Ala Pro Asn Arg Phe Tyr Trp Ser 
        195                 200                 205             


Met Met Val Ser Gly Arg Glu Pro Asp Leu Val His Leu Glu Ala Lys 
    210                 215                 220                 


Thr Val Asp Gly His Ala Gln Tyr Ile Thr Cys Lys Met Gln Asn Cys 
225                 230                 235                 240 


Ser Glu Ala Ser Gln Asn Lys Pro Phe Pro Gly Tyr Ile Asp His Asn 
                245                 250                 255     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            260                 265                 270         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Thr Pro 
        275                 280                 285             


Ile Lys Leu Pro Lys Tyr Ser Leu Pro Lys Asp Met His Val Ile Ser 
    290                 295                 300                 


Thr Asp Glu Ser Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
305                 310                 315                 320 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                325                 330                 335     


Leu Ala Leu Glu Asn Val Lys Ser Ser Gln Gly Leu Asp Gly Asn Val 
            340                 345                 350         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        355                 360                 365             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    370                 375                 380                 


Gly Arg Asp Trp Asn Leu Leu Gln Ala Pro Asp Thr Asp Leu Lys Gly 
385                 390                 395                 400 


Asn Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                405                 410                 415     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Asn Ile Ala Ser Arg Asp 
            420                 425                 430         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Pro Glu Leu 
        435                 440                 445             


Ser Asp Asn Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    450                 455                 460                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
465                 470                 475                 480 


Gly Gly Val Leu Val Ala Ile Lys His Thr Ser Leu Pro Ile Arg His 
                485                 490                 495     


Leu Trp Leu Ser Phe Asp Glu Gly Lys Ser Trp Ser Lys Tyr Ser Phe 
            500                 505                 510         


Thr Ser Leu Pro Leu Phe Val Asp Gly Ile Leu Gly Glu Pro Gly Glu 
        515                 520                 525             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    530                 535                 540                 


Trp Gln Leu Val Lys Ile Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
545                 550                 555                 560 


Ala Glu Glu Asp Tyr Trp Thr Trp Gln Leu His Ser Gln Gly Glu Ala 
                565                 570                 575     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Arg Lys Arg Lys Ser Glu Lys 
            580                 585                 590         


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Thr Ser Glu Pro Cys 
        595                 600                 605             


Val Cys Thr Asp Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    610                 615                 620                 


Arg Asn Gly Gln Cys Leu Pro Ala Phe Trp Tyr Asn Pro Ser Ser Leu 
625                 630                 635                 640 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                645                 650                 655     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            660                 665                 670         


Thr Ala Lys Pro Gln Gln Cys Pro Gly Lys Ala Pro Gln Gly Leu Arg 
        675                 680                 685             


Ile Ile Thr Ser Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    690                 695                 700                 


Thr Phe Leu Val Gln Leu Glu Glu Gly Asp Leu Gln Arg Ser Leu Ile 
705                 710                 715                 720 


Gln Val Asp Phe Gly Asp Gly Thr Ala Val Ser Tyr Ala Asn Leu Ser 
                725                 730                 735     


Ser Thr Glu Asp Gly Ile Lys His Thr Tyr Gln Asn Val Gly Ile Phe 
            740                 745                 750         


Arg Val Thr Val Leu Val Glu Asn Ser Leu Gly Ser Asp Asn Ala Val 
        755                 760                 765             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    770                 775                 780                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
785                 790                 795                 800 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Phe Gly Asn 
                805                 810                 815     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Thr Phe Thr Phe 
            820                 825                 830         


Ser Val Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        835                 840                 845             


Thr Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Gln Phe Arg 
    850                 855                 860                 


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
865                 870                 875                 880 


Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Val Lys Arg Ala Leu 
                885                 890                 895     


Val Glu Ala Thr Gly Ile Ser Ser Lys His Ile Leu Val Ala Val Leu 
            900                 905                 910         


Pro Gly Leu Pro Thr Ser Ala Glu Leu Phe Ile Leu Pro Tyr Gln Asp 
        915                 920                 925             


Ala Thr Gly Gly Asn Lys Arg Thr Glu Asp Leu Glu Gln Ile Ser Glu 
    930                 935                 940                 


Ile Leu Ile Gln Lys Leu Asn Gln Asn Phe Val His Phe Glu Leu Lys 
945                 950                 955                 960 


Pro Gly Val Arg Val Leu Val His Ala Ala His Leu Thr Ala Ala Pro 
                965                 970                 975     


Leu Val Asp Leu Thr Pro Ser His Ser Gly Ser Ala Met Leu Met Leu 
            980                 985                 990         


Leu Ser Val Val Phe Val Gly Leu  Ala Val Phe Val Ile  Tyr Lys Phe 
        995                 1000                 1005             


Lys Arg  Lys Ile Pro Gly Leu  Asn Ile Tyr Ala Gln  Met Gln Asn 
    1010                 1015                 1020             


Glu Lys  Asp Gln Glu Met Val  Ser Pro Val Ser Gln  Arg Glu Ser 
    1025                 1030                 1035             


Ile Pro  Asn Val Pro Gln Ser  Glu Leu Met Ser Pro  Glu Gln Leu 
    1040                 1045                 1050             


Val Asp  Glu Lys Leu Asp Val  Gln Pro Ile Glu Gln  Pro Gln Ala 
    1055                 1060                 1065             


Thr Val  Gln Asn Pro Arg Lys  Gly Asn Ala Ala Lys  Val Val Trp 
    1070                 1075                 1080             


Thr Glu  Asp Phe Gln Lys Ala  Cys Gly Ser Pro Arg  Gly Phe Lys 
    1085                 1090                 1095             


Pro Arg  Pro Gly Ala Glu Val  Phe Pro Gln Leu Leu  Ser Pro Arg 
    1100                 1105                 1110             


Ala Gln  Lys Lys Ser Leu Pro  Met 
    1115                 1120     


<210>  51
<211>  986
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<222>  (1)..(986)
<223>  soluble SorCS1

<400>  51

Gly Gln Ala Gly Gly Arg Arg Asn Ser Ala Arg Arg Arg Arg Gly Arg 
1               5                   10                  15      


Ser Pro Arg Gly Thr Ala Gly Pro Gly Gly Ala Ala Gly Arg Glu Pro 
            20                  25                  30          


Gly Gly Ser Gly Ala Ala Arg Phe Gly Leu Glu Glu Leu Arg Leu Gly 
        35                  40                  45              


Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala Met 
    50                  55                  60                  


Val His Trp Ser Gly Gln Asn Ser Ser Val Ile Leu Ile Leu Thr Lys 
65                  70                  75                  80  


Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp Arg 
                85                  90                  95      


Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Ile Gly 
            100                 105                 110         


Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys Arg 
        115                 120                 125             


Lys Ile Met Leu Leu Thr Asp Pro Glu Val Glu Ser Ser Leu Leu Ile 
    130                 135                 140                 


Ser Thr Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe Tyr 
145                 150                 155                 160 


Ile His Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu Ala 
                165                 170                 175     


Tyr Ser Gln Asp Gln Lys Leu Phe Ser Ser Val Glu Phe Gly Arg Arg 
            180                 185                 190         


Trp Leu Leu Leu His Glu Gly Val Ala Pro Asn Arg Phe Tyr Trp Ser 
        195                 200                 205             


Met Met Val Ser Gly Arg Glu Pro Asp Leu Val His Leu Glu Ala Lys 
    210                 215                 220                 


Thr Val Asp Gly His Ala Gln Tyr Ile Thr Cys Lys Met Gln Asn Cys 
225                 230                 235                 240 


Ser Glu Ala Ser Gln Asn Lys Pro Phe Pro Gly Tyr Ile Asp His Asn 
                245                 250                 255     


Ser Leu Ile Val Gln Asp Asp Tyr Val Phe Val Gln Leu Thr Ser Gly 
            260                 265                 270         


Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Thr Pro 
        275                 280                 285             


Ile Lys Leu Pro Lys Tyr Ser Leu Pro Lys Asp Met His Val Ile Ser 
    290                 295                 300                 


Thr Asp Glu Ser Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln Asn 
305                 310                 315                 320 


Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe Thr 
                325                 330                 335     


Leu Ala Leu Glu Asn Val Lys Ser Ser Gln Gly Leu Asp Gly Asn Val 
            340                 345                 350         


Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu Ala 
        355                 360                 365             


Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn Lys 
    370                 375                 380                 


Gly Arg Asp Trp Asn Leu Leu Gln Ala Pro Asp Thr Asp Leu Lys Gly 
385                 390                 395                 400 


Asn Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His Leu 
                405                 410                 415     


Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Asn Ile Ala Ser Arg Asp 
            420                 425                 430         


Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Pro Glu Leu 
        435                 440                 445             


Ser Asp Asn Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn Thr 
    450                 455                 460                 


Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp Gln 
465                 470                 475                 480 


Gly Gly Val Leu Val Ala Ile Lys His Thr Ser Leu Pro Ile Arg His 
                485                 490                 495     


Leu Trp Leu Ser Phe Asp Glu Gly Lys Ser Trp Ser Lys Tyr Ser Phe 
            500                 505                 510         


Thr Ser Leu Pro Leu Phe Val Asp Gly Ile Leu Gly Glu Pro Gly Glu 
        515                 520                 525             


Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser Glu 
    530                 535                 540                 


Trp Gln Leu Val Lys Ile Asp Tyr Lys Ser Ile Phe Asp Arg Arg Cys 
545                 550                 555                 560 


Ala Glu Glu Asp Tyr Trp Thr Trp Gln Leu His Ser Gln Gly Glu Ala 
                565                 570                 575     


Cys Ile Met Gly Ala Lys Arg Ile Tyr Arg Lys Arg Lys Ser Glu Lys 
            580                 585                 590         


Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Thr Ser Glu Pro Cys 
        595                 600                 605             


Val Cys Thr Asp Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg His 
    610                 615                 620                 


Arg Asn Gly Gln Cys Leu Pro Ala Phe Trp Tyr Asn Pro Ser Ser Leu 
625                 630                 635                 640 


Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly Tyr 
                645                 650                 655     


Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln Tyr 
            660                 665                 670         


Thr Ala Lys Pro Gln Gln Cys Pro Gly Lys Ala Pro Gln Gly Leu Arg 
        675                 680                 685             


Ile Ile Thr Ser Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn Val 
    690                 695                 700                 


Thr Phe Leu Val Gln Leu Glu Glu Gly Asp Leu Gln Arg Ser Leu Ile 
705                 710                 715                 720 


Gln Val Asp Phe Gly Asp Gly Thr Ala Val Ser Tyr Ala Asn Leu Ser 
                725                 730                 735     


Ser Thr Glu Asp Gly Ile Lys His Thr Tyr Gln Asn Val Gly Ile Phe 
            740                 745                 750         


Arg Val Thr Val Leu Val Glu Asn Ser Leu Gly Ser Asp Asn Ala Val 
        755                 760                 765             


Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser Leu 
    770                 775                 780                 


Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val Leu 
785                 790                 795                 800 


Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Phe Gly Asn 
                805                 810                 815     


Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Thr Phe Thr Phe 
            820                 825                 830         


Ser Val Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly Asn 
        835                 840                 845             


Thr Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Gln Phe Arg 
    850                 855                 860                 


Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro Asp 
865                 870                 875                 880 


Ile Pro Glu Trp Arg Arg Asp Ile Ser Arg Val Val Lys Arg Ala Leu 
                885                 890                 895     


Val Glu Ala Thr Gly Ile Ser Ser Lys His Ile Leu Val Ala Val Leu 
            900                 905                 910         


Pro Gly Leu Pro Thr Ser Ala Glu Leu Phe Ile Leu Pro Tyr Gln Asp 
        915                 920                 925             


Ala Thr Gly Gly Asn Lys Arg Thr Glu Asp Leu Glu Gln Ile Ser Glu 
    930                 935                 940                 


Ile Leu Ile Gln Lys Leu Asn Gln Asn Phe Val His Phe Glu Leu Lys 
945                 950                 955                 960 


Pro Gly Val Arg Val Leu Val His Ala Ala His Leu Thr Ala Ala Pro 
                965                 970                 975     


Leu Val Asp Leu Thr Pro Ser His Ser Gly 
            980                 985     


<210>  52
<211>  831
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(831)
<223>  preproSortilin

<400>  52

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  53
<211>  2214
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(2214)
<223>  preproSorLA

<400>  53

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Glu Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Ile Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  54
<211>  1159
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1159)
<223>  preproSorCS2

<400>  54

Met Ala His Arg Gly Pro Ser Arg Ala Ser Lys Gly Pro Gly Pro Thr 
1               5                   10                  15      


Ala Arg Ala Pro Ser Pro Gly Ala Pro Pro Pro Pro Arg Ser Pro Arg 
            20                  25                  30          


Ser Arg Pro Leu Leu Leu Leu Leu Leu Leu Leu Gly Ala Cys Gly Ala 
        35                  40                  45              


Ala Gly Arg Ser Pro Glu Pro Gly Arg Leu Gly Pro His Ala Gln Leu 
    50                  55                  60                  


Thr Arg Val Pro Arg Ser Pro Pro Ala Gly Arg Ala Glu Pro Gly Gly 
65                  70                  75                  80  


Gly Glu Asp Arg Gln Ala Arg Gly Thr Glu Pro Gly Ala Pro Gly Pro 
                85                  90                  95      


Ser Pro Gly Pro Ala Pro Gly Pro Gly Glu Asp Gly Ala Pro Ala Ala 
            100                 105                 110         


Gly Tyr Arg Arg Trp Glu Arg Ala Ala Pro Leu Ala Gly Val Ala Ser 
        115                 120                 125             


Arg Ala Gln Val Ser Leu Ile Ser Thr Ser Phe Val Leu Lys Gly Asp 
    130                 135                 140                 


Ala Thr His Asn Gln Ala Met Val His Trp Thr Gly Glu Asn Ser Ser 
145                 150                 155                 160 


Val Ile Leu Ile Leu Thr Lys Tyr Tyr His Ala Asp Met Gly Lys Val 
                165                 170                 175     


Leu Glu Ser Ser Leu Trp Arg Ser Ser Asp Phe Gly Thr Ser Tyr Thr 
            180                 185                 190         


Lys Leu Thr Leu Gln Pro Gly Val Thr Thr Val Ile Asp Asn Phe Tyr 
        195                 200                 205             


Ile Cys Pro Thr Asn Lys Arg Lys Val Ile Leu Val Ser Ser Ser Leu 
    210                 215                 220                 


Ser Asp Arg Asp Gln Ser Leu Phe Leu Ser Ala Asp Glu Gly Ala Thr 
225                 230                 235                 240 


Phe Gln Lys Gln Pro Ile Pro Phe Phe Val Glu Thr Leu Ile Phe His 
                245                 250                 255     


Pro Lys Glu Glu Asp Lys Val Leu Ala Tyr Thr Lys Glu Ser Lys Leu 
            260                 265                 270         


Tyr Val Ser Ser Asp Leu Gly Lys Lys Trp Thr Leu Leu Gln Glu Arg 
        275                 280                 285             


Val Thr Lys Asp His Val Phe Trp Ser Val Ser Gly Val Asp Ala Asp 
    290                 295                 300                 


Pro Asp Leu Val His Val Glu Ala Gln Asp Leu Gly Gly Asp Phe Arg 
305                 310                 315                 320 


Tyr Val Thr Cys Ala Ile His Asn Cys Ser Glu Lys Met Leu Thr Ala 
                325                 330                 335     


Pro Phe Ala Gly Pro Ile Asp His Gly Ser Leu Thr Val Gln Asp Asp 
            340                 345                 350         


Tyr Ile Phe Phe Lys Ala Thr Ser Ala Asn Gln Thr Lys Tyr Tyr Val 
        355                 360                 365             


Ser Tyr Arg Arg Asn Glu Phe Val Leu Met Lys Leu Pro Lys Tyr Ala 
    370                 375                 380                 


Leu Pro Lys Asp Leu Gln Ile Ile Ser Thr Asp Glu Ser Gln Val Phe 
385                 390                 395                 400 


Val Ala Val Gln Glu Trp Tyr Gln Met Asp Thr Tyr Asn Leu Tyr Gln 
                405                 410                 415     


Ser Asp Pro Arg Gly Val Arg Tyr Ala Leu Val Leu Gln Asp Val Arg 
            420                 425                 430         


Ser Ser Arg Gln Ala Glu Glu Ser Val Leu Ile Asp Ile Leu Glu Val 
        435                 440                 445             


Arg Gly Val Lys Gly Val Phe Leu Ala Asn Gln Lys Ile Asp Gly Lys 
    450                 455                 460                 


Val Met Thr Leu Ile Thr Tyr Asn Lys Gly Arg Asp Trp Asp Tyr Leu 
465                 470                 475                 480 


Arg Pro Pro Ser Met Asp Met Asn Gly Lys Pro Thr Asn Cys Lys Pro 
                485                 490                 495     


Pro Asp Cys His Leu His Leu His Leu Arg Trp Ala Asp Asn Pro Tyr 
            500                 505                 510         


Val Ser Gly Thr Val His Thr Lys Asp Thr Ala Pro Gly Leu Ile Met 
        515                 520                 525             


Gly Ala Gly Asn Leu Gly Ser Gln Leu Val Glu Tyr Lys Glu Glu Met 
    530                 535                 540                 


Tyr Ile Thr Ser Asp Cys Gly His Thr Trp Arg Gln Val Phe Glu Glu 
545                 550                 555                 560 


Glu His His Ile Leu Tyr Leu Asp His Gly Gly Val Ile Val Ala Ile 
                565                 570                 575     


Lys Asp Thr Ser Ile Pro Leu Lys Ile Leu Lys Phe Ser Val Asp Glu 
            580                 585                 590         


Gly Leu Thr Trp Ser Thr His Asn Phe Thr Ser Thr Ser Val Phe Val 
        595                 600                 605             


Asp Gly Leu Leu Ser Glu Pro Gly Asp Glu Thr Leu Val Met Thr Val 
    610                 615                 620                 


Phe Gly His Ile Ser Phe Arg Ser Asp Trp Glu Leu Val Lys Val Asp 
625                 630                 635                 640 


Phe Arg Pro Ser Phe Ser Arg Gln Cys Gly Glu Glu Asp Tyr Ser Ser 
                645                 650                 655     


Trp Glu Leu Ser Asn Leu Gln Gly Asp Arg Cys Ile Met Gly Gln Gln 
            660                 665                 670         


Arg Ser Phe Arg Lys Arg Lys Ser Thr Ser Trp Cys Ile Lys Gly Arg 
        675                 680                 685             


Ser Phe Thr Ser Ala Leu Thr Ser Arg Val Cys Glu Cys Arg Asp Ser 
    690                 695                 700                 


Asp Phe Leu Cys Asp Tyr Gly Phe Glu Arg Ser Pro Ser Ser Glu Ser 
705                 710                 715                 720 


Ser Thr Asn Lys Cys Ser Ala Asn Phe Trp Phe Asn Pro Leu Ser Pro 
                725                 730                 735     


Pro Asp Asp Cys Ala Leu Gly Gln Thr Tyr Thr Ser Ser Leu Gly Tyr 
            740                 745                 750         


Arg Lys Val Val Ser Asn Val Cys Glu Gly Gly Val Asp Met Gln Gln 
        755                 760                 765             


Ser Gln Val Gln Leu Gln Cys Pro Leu Thr Pro Pro Arg Gly Leu Gln 
    770                 775                 780                 


Val Ser Ile Gln Gly Glu Ala Val Ala Val Arg Pro Gly Glu Asp Val 
785                 790                 795                 800 


Leu Phe Val Val Arg Gln Glu Gln Gly Asp Val Leu Thr Thr Lys Tyr 
                805                 810                 815     


Gln Val Asp Leu Gly Asp Gly Phe Lys Ala Met Tyr Val Asn Leu Thr 
            820                 825                 830         


Leu Thr Gly Glu Pro Ile Arg His Arg Tyr Glu Ser Pro Gly Ile Tyr 
        835                 840                 845             


Arg Val Ser Val Arg Ala Glu Asn Thr Ala Gly His Asp Glu Ala Val 
    850                 855                 860                 


Leu Phe Val Gln Val Asn Ser Pro Leu Gln Ala Leu Tyr Leu Glu Val 
865                 870                 875                 880 


Val Pro Val Ile Gly Leu Asn Gln Glu Val Asn Leu Thr Ala Val Leu 
                885                 890                 895     


Leu Pro Leu Asn Pro Asn Leu Thr Val Phe Tyr Trp Trp Ile Gly His 
            900                 905                 910         


Ser Leu Gln Pro Leu Leu Ser Leu Asp Asn Ser Val Thr Thr Arg Phe 
        915                 920                 925             


Ser Asp Thr Gly Asp Val Arg Val Thr Val Gln Ala Ala Cys Gly Asn 
    930                 935                 940                 


Ser Val Leu Gln Asp Ser Arg Val Leu Arg Val Leu Asp Gln Phe Gln 
945                 950                 955                 960 


Val Met Pro Leu Gln Phe Ser Lys Glu Leu Asp Ala Tyr Asn Pro Asn 
                965                 970                 975     


Thr Pro Glu Trp Arg Glu Asp Val Gly Leu Val Val Thr Arg Leu Leu 
            980                 985                 990         


Ser Lys Glu Thr Ser Val Pro Gln  Glu Leu Leu Val Thr  Val Val Lys 
        995                 1000                 1005             


Pro Gly  Leu Pro Thr Leu Ala  Asp Leu Tyr Val Leu  Leu Pro Pro 
    1010                 1015                 1020             


Pro Arg  Pro Thr Arg Lys Arg  Ser Leu Ser Ser Asp  Lys Arg Leu 
    1025                 1030                 1035             


Ala Ala  Ile Gln Gln Val Leu  Asn Ala Gln Lys Ile  Ser Phe Leu 
    1040                 1045                 1050             


Leu Arg  Gly Gly Val Arg Val  Leu Val Ala Leu Arg  Asp Thr Gly 
    1055                 1060                 1065             


Thr Gly  Ala Glu Gln Leu Gly  Gly Gly Gly Gly Tyr  Trp Ala Val 
    1070                 1075                 1080             


Val Val  Leu Phe Val Ile Gly  Leu Phe Ala Ala Gly  Ala Phe Ile 
    1085                 1090                 1095             


Leu Tyr  Lys Phe Lys Arg Lys  Arg Pro Gly Arg Thr  Val Tyr Ala 
    1100                 1105                 1110             


Gln Met  His Asn Glu Lys Glu  Gln Glu Met Thr Ser  Pro Val Ser 
    1115                 1120                 1125             


His Ser  Glu Asp Val Gln Gly  Ala Val Gln Gly Asn  His Ser Gly 
    1130                 1135                 1140             


Val Val  Leu Ser Ile Asn Ser  Arg Glu Met His Ser  Tyr Leu Val 
    1145                 1150                 1155             


Ser 
    


<210>  55
<211>  1222
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1222)
<223>  preproSorCS3

<400>  55

Met Glu Ala Ala Arg Thr Glu Arg Pro Ala Gly Arg Pro Gly Ala Pro 
1               5                   10                  15      


Leu Val Arg Thr Gly Leu Leu Leu Leu Ser Thr Trp Val Leu Ala Gly 
            20                  25                  30          


Ala Glu Ile Thr Trp Asp Ala Thr Gly Gly Pro Gly Arg Pro Ala Ala 
        35                  40                  45              


Pro Ala Ser Arg Pro Pro Ala Leu Ser Pro Leu Ser Pro Arg Ala Val 
    50                  55                  60                  


Ala Ser Gln Trp Pro Glu Glu Leu Ala Ser Ala Arg Arg Ala Ala Val 
65                  70                  75                  80  


Leu Gly Arg Arg Ala Gly Pro Glu Leu Leu Pro Gln Gln Gly Gly Gly 
                85                  90                  95      


Arg Gly Gly Glu Met Gln Val Glu Ala Gly Gly Thr Ser Pro Ala Gly 
            100                 105                 110         


Glu Arg Arg Gly Arg Gly Ile Pro Ala Pro Ala Lys Leu Gly Gly Ala 
        115                 120                 125             


Arg Arg Ser Arg Arg Ala Gln Pro Pro Ile Thr Gln Glu Arg Gly Asp 
    130                 135                 140                 


Ala Trp Ala Thr Ala Pro Ala Asp Gly Ser Arg Gly Ser Arg Pro Leu 
145                 150                 155                 160 


Ala Lys Gly Ser Arg Glu Glu Val Lys Ala Pro Arg Ala Gly Gly Ser 
                165                 170                 175     


Ala Ala Glu Asp Leu Arg Leu Pro Ser Thr Ser Phe Ala Leu Thr Gly 
            180                 185                 190         


Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly His Asn Ser 
        195                 200                 205             


Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Phe Asn Leu Gly Ser 
    210                 215                 220                 


Val Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr 
225                 230                 235                 240 


Glu Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Val Leu Ser Tyr Leu 
                245                 250                 255     


Tyr Val Asn Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Ser Asp Pro 
            260                 265                 270         


Glu Met Glu Ser Ser Ile Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr 
        275                 280                 285             


Gln Lys Tyr Arg Leu Thr Phe Tyr Ile Gln Ser Leu Leu Phe His Pro 
    290                 295                 300                 


Lys Gln Glu Asp Trp Val Leu Ala Tyr Ser Leu Asp Gln Lys Leu Tyr 
305                 310                 315                 320 


Ser Ser Met Asp Phe Gly Arg Arg Trp Gln Leu Met His Glu Arg Ile 
                325                 330                 335     


Thr Pro Asn Arg Phe Tyr Trp Ser Val Ala Gly Leu Asp Lys Glu Ala 
            340                 345                 350         


Asp Leu Val His Met Glu Val Arg Thr Thr Asp Gly Tyr Ala His Tyr 
        355                 360                 365             


Leu Thr Cys Arg Ile Gln Glu Cys Ala Glu Thr Thr Arg Ser Gly Pro 
    370                 375                 380                 


Phe Ala Arg Ser Ile Asp Ile Ser Ser Leu Val Val Gln Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Ile Gln Val Thr Thr Ser Gly Arg Ala Ser Tyr Tyr Val Ser 
                405                 410                 415     


Tyr Arg Arg Glu Ala Phe Ala Gln Ile Lys Leu Pro Lys Tyr Ser Leu 
            420                 425                 430         


Pro Lys Asp Met His Ile Ile Ser Thr Asp Glu Asn Gln Val Phe Ala 
        435                 440                 445             


Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser 
    450                 455                 460                 


Asp Thr Arg Gly Ile Tyr Phe Thr Leu Ala Met Glu Asn Ile Lys Ser 
465                 470                 475                 480 


Ser Arg Gly Leu Met Gly Asn Ile Ile Ile Glu Leu Tyr Glu Val Ala 
                485                 490                 495     


Gly Ile Lys Gly Ile Phe Leu Ala Asn Lys Lys Val Asp Asp Gln Val 
            500                 505                 510         


Lys Thr Tyr Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln 
        515                 520                 525             


Ala Pro Asp Val Asp Leu Arg Gly Ser Pro Val His Cys Leu Leu Pro 
    530                 535                 540                 


Phe Cys Ser Leu His Leu His Leu Gln Leu Ser Glu Asn Pro Tyr Ser 
545                 550                 555                 560 


Ser Gly Arg Ile Ser Ser Lys Glu Thr Ala Pro Gly Leu Val Val Ala 
                565                 570                 575     


Thr Gly Asn Ile Gly Pro Glu Leu Ser Tyr Thr Asp Ile Gly Val Phe 
            580                 585                 590         


Ile Ser Ser Asp Gly Gly Asn Thr Trp Arg Gln Ile Phe Asp Glu Glu 
        595                 600                 605             


Tyr Asn Val Trp Phe Leu Asp Trp Gly Gly Ala Leu Val Ala Met Lys 
    610                 615                 620                 


His Thr Pro Leu Pro Val Arg His Leu Trp Val Ser Phe Asp Glu Gly 
625                 630                 635                 640 


His Ser Trp Asp Lys Tyr Gly Phe Thr Ser Val Pro Leu Phe Val Asp 
                645                 650                 655     


Gly Ala Leu Val Glu Ala Gly Met Glu Thr His Ile Met Thr Val Phe 
            660                 665                 670         


Gly His Phe Ser Leu Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr 
        675                 680                 685             


Lys Ser Ile Phe Ser Arg His Cys Thr Lys Glu Asp Tyr Gln Thr Trp 
    690                 695                 700                 


His Leu Leu Asn Gln Gly Glu Pro Cys Val Met Gly Glu Arg Lys Ile 
705                 710                 715                 720 


Phe Lys Lys Arg Lys Pro Gly Ala Gln Cys Ala Leu Gly Arg Asp His 
                725                 730                 735     


Ser Gly Ser Val Val Ser Glu Pro Cys Val Cys Ala Asn Trp Asp Phe 
            740                 745                 750         


Glu Cys Asp Tyr Gly Tyr Glu Arg His Gly Glu Ser Gln Cys Val Pro 
        755                 760                 765             


Ala Phe Trp Tyr Asn Pro Ala Ser Pro Ser Lys Asp Cys Ser Leu Gly 
    770                 775                 780                 


Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Arg Ile Val Ser Asn Asn 
785                 790                 795                 800 


Cys Thr Asp Gly Leu Arg Glu Lys Tyr Thr Ala Lys Ala Gln Met Cys 
                805                 810                 815     


Pro Gly Lys Ala Pro Arg Gly Leu His Val Val Thr Thr Asp Gly Arg 
            820                 825                 830         


Leu Val Ala Glu Gln Gly His Asn Ala Thr Phe Ile Ile Leu Met Glu 
        835                 840                 845             


Glu Gly Asp Leu Gln Arg Thr Asn Ile Gln Leu Asp Phe Gly Asp Gly 
    850                 855                 860                 


Ile Ala Val Ser Tyr Ala Asn Phe Ser Pro Ile Glu Asp Gly Ile Lys 
865                 870                 875                 880 


His Val Tyr Lys Ser Ala Gly Ile Phe Gln Val Thr Ala Tyr Ala Glu 
                885                 890                 895     


Asn Asn Leu Gly Ser Asp Thr Ala Val Leu Phe Leu His Val Val Cys 
            900                 905                 910         


Pro Val Glu His Val His Leu Arg Val Pro Phe Val Ala Ile Arg Asn 
        915                 920                 925             


Lys Glu Val Asn Ile Ser Ala Val Val Trp Pro Ser Gln Leu Gly Thr 
    930                 935                 940                 


Leu Thr Tyr Phe Trp Trp Phe Gly Asn Ser Thr Lys Pro Leu Ile Thr 
945                 950                 955                 960 


Leu Asp Ser Ser Ile Ser Phe Thr Phe Leu Ala Glu Gly Thr Asp Thr 
                965                 970                 975     


Ile Thr Val Gln Val Ala Ala Gly Asn Ala Leu Ile Gln Asp Thr Lys 
            980                 985                 990         


Glu Ile Ala Val His Glu Tyr Phe  Gln Ser Gln Leu Leu  Ser Phe Ser 
        995                 1000                 1005             


Pro Asn  Leu Asp Tyr His Asn  Pro Asp Ile Pro Glu  Trp Arg Lys 
    1010                 1015                 1020             


Asp Ile  Gly Asn Val Ile Lys  Arg Ala Leu Val Lys  Val Thr Ser 
    1025                 1030                 1035             


Val Pro  Glu Asp Gln Ile Leu  Ile Ala Val Phe Pro  Gly Leu Pro 
    1040                 1045                 1050             


Thr Ser  Ala Glu Leu Phe Ile  Leu Pro Pro Lys Asn  Leu Thr Glu 
    1055                 1060                 1065             


Arg Arg  Lys Gly Asn Glu Gly  Asp Leu Glu Gln Ile  Val Glu Thr 
    1070                 1075                 1080             


Leu Phe  Asn Ala Leu Asn Gln  Asn Leu Val Gln Phe  Glu Leu Lys 
    1085                 1090                 1095             


Pro Gly  Val Gln Val Ile Val  Tyr Val Thr Gln Leu  Thr Leu Ala 
    1100                 1105                 1110             


Pro Leu  Val Asp Ser Ser Ala  Gly His Ser Ser Ser  Ala Met Leu 
    1115                 1120                 1125             


Met Leu  Leu Ser Val Val Phe  Val Gly Leu Ala Val  Phe Leu Ile 
    1130                 1135                 1140             


Tyr Lys  Phe Lys Arg Lys Ile  Pro Trp Ile Asn Ile  Tyr Ala Gln 
    1145                 1150                 1155             


Val Gln  His Asp Lys Glu Gln  Glu Met Ile Gly Ser  Val Ser Gln 
    1160                 1165                 1170             


Ser Glu  Asn Ala Pro Lys Ile  Thr Leu Ser Asp Phe  Thr Glu Pro 
    1175                 1180                 1185             


Glu Glu  Leu Leu Asp Lys Glu  Leu Asp Thr Arg Val  Ile Gly Gly 
    1190                 1195                 1200             


Ile Ala  Thr Ile Ala Asn Ser  Glu Ser Thr Lys Glu  Ile Pro Asn 
    1205                 1210                 1215             


Cys Thr  Ser Val 
    1220         


<210>  56
<211>  1382
<212>  PRT
<213>  Homo sapiens
Human Insulin Receptor

<400>  56

Met Gly Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


