
                                SEQUENCE LISTING

<110> Novartis AG
      Massachusetts Institute Of Technology
      CHENNAMSETTY, Naresh
      HELK, Bernard
      KAYSER, Veysel
      TROUT, Bernhardt
      VOYNOV, Vladimir

<120> METHODS FOR IDENTIFICATION OF SITES FOR
      IgG CONJUGATION

<130> 61967-20002.40

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> 61/184,084          
<151> 2009-06-04  

<160> 18

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 103
<212> PRT
<213> Homo sapiens

<400> 1
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys
            100             


<210> 2
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys
            100             


<210> 3
<211> 103
<212> PRT
<213> Homo sapiens

<400> 3
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly
            100             


<210> 4
<211> 103
<212> PRT
<213> Homo sapiens

<400> 4
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Thr Pro
            100             


<210> 5
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
 1               5                  10                  15      
Gly
    


<210> 6
<211> 13
<212> PRT
<213> Homo sapiens

<400> 6
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly
 1               5                  10              


<210> 7
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7
Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly
 1               5                  10                  


<210> 8
<211> 26
<212> PRT
<213> Homo sapiens

<400> 8
Leu Gly Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Cys Pro
 1               5                  10                  15      
Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly
            20                  25      


<210> 9
<211> 108
<212> PRT
<213> Homo sapiens

<400> 9
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
 1               5                  10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            20                  25                  30          
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        35                  40                  45              
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    50                  55                  60                  
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
65                  70                  75                  80  
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                85                  90                  95      
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            100                 105             


<210> 10
<211> 108
<212> PRT
<213> Homo sapiens

<400> 10
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
 1               5                  10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            20                  25                  30          
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        35                  40                  45              
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg
    50                  55                  60                  
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys
65                  70                  75                  80  
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu
                85                  90                  95      
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
            100                 105             


<210> 11
<211> 108
<212> PRT
<213> Homo sapiens

<400> 11
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
 1               5                  10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            20                  25                  30          
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        35                  40                  45              
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    50                  55                  60                  
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
65                  70                  75                  80  
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                85                  90                  95      
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            100                 105             


<210> 12
<211> 108
<212> PRT
<213> Homo sapiens

<400> 12
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
 1               5                  10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            20                  25                  30          
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        35                  40                  45              
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    50                  55                  60                  
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
65                  70                  75                  80  
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                85                  90                  95      
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
            100                 105             


<210> 13
<211> 102
<212> PRT
<213> Homo sapiens

<400> 13
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
 1               5                  10                  15      
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            20                  25                  30          
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        35                  40                  45              
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
    50                  55                  60                  
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
65                  70                  75                  80  
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
                85                  90                  95      
Ser Leu Ser Pro Gly Lys
            100         


<210> 14
<211> 102
<212> PRT
<213> Homo sapiens

<400> 14
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
 1               5                  10                  15      
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            20                  25                  30          
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        35                  40                  45              
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
    50                  55                  60                  
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
65                  70                  75                  80  
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
                85                  90                  95      
Ser Leu Ser Pro Gly Lys
            100         


<210> 15
<211> 102
<212> PRT
<213> Homo sapiens

<400> 15
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn
 1               5                  10                  15      
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            20                  25                  30          
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        35                  40                  45              
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg
    50                  55                  60                  
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys
65                  70                  75                  80  
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
                85                  90                  95      
Ser Leu Ser Leu Gly Lys
            100         


<210> 16
<211> 102
<212> PRT
<213> Homo sapiens

<400> 16
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
 1               5                  10                  15      
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            20                  25                  30          
Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        35                  40                  45              
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
    50                  55                  60                  
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys
65                  70                  75                  80  
Ser Val Met His Glu Ala Leu His Asn His Phe Thr Gln Lys Ser Leu
                85                  90                  95      
Ser Leu Ser Pro Gly Lys
            100         


<210> 17
<211> 103
<212> PRT
<213> Homo sapiens

<400> 17
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu
 1               5                  10                  15      
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro
            20                  25                  30          
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala
        35                  40                  45              
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala
    50                  55                  60                  
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg
65                  70                  75                  80  
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr
                85                  90                  95      
Val Ala Pro Thr Glu Cys Ser
            100             


<210> 18
<211> 105
<212> PRT
<213> Homo sapiens

<400> 18
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
 1               5                  10                  15      
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
            20                  25                  30          
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly
        35                  40                  45              
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr
    50                  55                  60                  
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His
65                  70                  75                  80  
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
                85                  90                  95      
Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105 

