                         SEQUENCE LISTING

<110>  SYNARC SAS
       INSERM-TRANSFERT SA
 
<120>  SEQUENCES, ANTICORPS, PROCEDES ET NECESSAIRES POUR LA DETECTION 
       ET LE DOSAGE  IN VITRO DE LA PERIOSTINE, EN VUE DU DIAGNOTIC DU 
       SUIVI OU DU PRONOSTIC DE PATHOLOGIES OU DE PHENOMENES BIOLOGIQUES
        IMPLIQUANT LA PERIOSTINE

<130>  BFF070455

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  1

Lys Gly Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly 
1               5                   10                  15      


Ser Lys 
        


<210>  2
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  2

Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp Ser 
1               5                   10                  15      


Ile 
    


<210>  3
<211>  17
<212>  PRT
<213>  mus musculus

<400>  3

Glu Ala Ile Thr Gly Gly Ala Val Gly Glu Ala Ile Thr Gly Gly Ala 
1               5                   10                  15      


Val 
    


<210>  4
<211>  836
<212>  PRT
<213>  homo sapiens

<400>  4

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  5
<211>  838
<212>  PRT
<213>  mus musculus

<400>  5

Met Val Pro Leu Leu Pro Leu Tyr Ala Leu Leu Leu Leu Phe Leu Cys 
1               5                   10                  15      


Asp Ile Asn Pro Ala Asn Ala Asn Ser Tyr Tyr Asp Lys Val Leu Ala 
            20                  25                  30          


His Ser Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu 
        35                  40                  45              


Gln Gln Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Ser Cys Lys Asn 
    50                  55                  60                  


Trp Tyr Gln Gly Ala Ile Cys Gly Lys Lys Thr Thr Val Leu Tyr Glu 
65                  70                  75                  80  


Cys Cys Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala 
                85                  90                  95      


Val Met Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala 
            100                 105                 110         


Thr Thr Thr Gln His Tyr Ser Asp Val Ser Lys Leu Arg Glu Glu Ile 
        115                 120                 125             


Glu Gly Lys Gly Ser Tyr Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp 
    130                 135                 140                 


Glu Asn Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Asn Asn Val Asn 
145                 150                 155                 160 


Val Glu Leu Leu Asn Ala Leu His Ser His Met Val Asn Lys Arg Met 
                165                 170                 175     


Leu Thr Lys Asp Leu Lys His Gly Met Val Ile Pro Ser Met Tyr Asn 
            180                 185                 190         


Asn Leu Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val 
        195                 200                 205             


Asn Cys Ala Arg Val Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val 
    210                 215                 220                 


Val His Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln 
225                 230                 235                 240 


Asp Phe Leu Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala 
                245                 250                 255     


Ile Thr Ser Asp Leu Leu Glu Ser Leu Gly Arg Asp Gly His Phe Thr 
            260                 265                 270         


Leu Phe Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val 
        275                 280                 285             


Leu Glu Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys 
    290                 295                 300                 


Tyr His Ile Leu Asn Thr Leu Gln Cys Ser Glu Ala Ile Thr Gly Gly 
305                 310                 315                 320 


Ala Val Phe Glu Thr Met Glu Gly Asn Thr Ile Glu Ile Gly Cys Glu 
                325                 330                 335     


Gly Asp Ser Ile Ser Ile Asn Gly Ile Lys Met Val Asn Lys Lys Asp 
            340                 345                 350         


Ile Val Thr Lys Asn Gly Val Ile His Leu Ile Asp Glu Val Leu Ile 
        355                 360                 365             


Pro Asp Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr 
    370                 375                 380                 


Thr Phe Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ser Leu Lys 
385                 390                 395                 400 


Pro Asp Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser 
                405                 410                 415     


Asp Asp Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln 
            420                 425                 430         


Asn His Ile Leu Lys Val Lys Val Gly Leu Ser Asp Leu Tyr Asn Gly 
        435                 440                 445             


Gln Ile Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr 
    450                 455                 460                 


Arg Thr Ala Ile Cys Ile Glu Asn Ser Cys Met Val Arg Gly Ser Lys 
465                 470                 475                 480 


Gln Gly Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Gln Pro 
                485                 490                 495     


Ala Glu Lys Ser Leu His Asp Lys Leu Arg Gln Asp Lys Arg Phe Ser 
            500                 505                 510         


Ile Phe Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Asp Leu Leu Thr 
        515                 520                 525             


Gln Pro Gly Asp Trp Thr Leu Phe Ala Pro Thr Asn Asp Ala Phe Lys 
    530                 535                 540                 


Gly Met Thr Ser Glu Glu Arg Glu Leu Leu Ile Gly Asp Lys Asn Ala 
545                 550                 555                 560 


Leu Gln Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Tyr Ile Gly 
                565                 570                 575     


Lys Gly Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly 
            580                 585                 590         


Ser Lys Ile Tyr Leu Lys Gly Val Asn Glu Thr Leu Leu Val Asn Glu 
        595                 600                 605             


Leu Lys Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His 
    610                 615                 620                 


Val Val Asp Lys Leu Leu Tyr Pro Ala Asp Ile Pro Val Gly Asn Asp 
625                 630                 635                 640 


Gln Leu Leu Glu Leu Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys 
                645                 650                 655     


Phe Val Arg Gly Ser Thr Phe Lys Glu Ile Pro Met Thr Val Tyr Thr 
            660                 665                 670         


Thr Lys Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Gln 
        675                 680                 685             


Gly Ser Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Ala Met Thr Lys 
    690                 695                 700                 


Ile Gln Ile Glu Gly Asp Pro Asp Phe Arg Leu Ile Lys Glu Gly Glu 
705                 710                 715                 720 


Thr Val Thr Glu Val Ile His Gly Glu Pro Val Ile Lys Lys Tyr Thr 
                725                 730                 735     


Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Gln Thr Arg 
            740                 745                 750         


Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser 
        755                 760                 765             


Thr Gly Gly Gly Glu Thr Gly Glu Thr Leu Gln Lys Phe Leu Gln Lys 
    770                 775                 780                 


Glu Val Ser Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu 
785                 790                 795                 800 


Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Ala 
                805                 810                 815     


Lys Lys Ile Pro Ala Asn Lys Arg Val Gln Gly Pro Arg Arg Arg Ser 
            820                 825                 830         


Arg Glu Gly Arg Ser Gln 
        835             


