                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Frderung der Wissenschaften e.V.
 
<120>  Treatment of oncostatin M receptor  mediated heart failure

<130>  R1114 PCT

<150>  EP 09 00 7319.8

<151>  2009-06-02

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  979
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


<210>  2
<211>  4171
<212>  DNA
<213>  homo sapiens

<400>  2
gggccgcctc tgcacgtccg ccccggagcc cgcacccgcg ccccacgcgc cgccgaggac     60

tcggcccggc tcgtggagcc cttcgcccgc ggcgtgagta cccccgaccc gcccgtcccc    120

gctctgctcg cgccctgccg ctgcgccgcc ctcggtggct tttccgacgg gcgagccccg    180

tgctgtgcgg gaaagaatcc gacaacttcg cagcccatcc cggctggacg cgaccgggag    240

tgcagcagcc cgttcccctc ctcggtgccg cctctgccca gcgtttgctt ggctgggcta    300

ccacctgcgc tcggacggcg ctcggagggt cctcgccccc ggcctgccta cctgaaaacc    360

agaactgatg gctctatttg cagtctttca gacaacattc ttcttaacat tgctgtcctt    420

gaggacttac cagagtgaag tcttggctga acgtttacca ttgactcctg tatcacttaa    480

agtttccacc aattctacgc gtcagagttt gcacttacaa tggactgtcc acaaccttcc    540

ttatcatcag gaattgaaaa tggtatttca gatccagatc agtaggattg aaacatccaa    600

tgtcatctgg gtggggaatt acagcaccac tgtgaagtgg aaccaggttc tgcattggag    660

ctgggaatct gagctccctt tggaatgtgc cacacacttt gtaagaataa agagtttggt    720

ggacgatgcc aagttccctg agccaaattt ctggagcaac tggagttcct gggaggaagt    780

cagtgtacaa gattctactg gacaggatat attgttcgtt ttccctaaag ataagctggt    840

ggaagaaggc accaatgtta ccatttgtta cgtttctagg aacattcaaa ataatgtatc    900

ctgttatttg gaagggaaac agattcatgg agaacaactt gatccacatg taactgcatt    960

caacttgaat agtgtgcctt tcattaggaa taaagggaca aatatctatt gtgaggcaag   1020

tcaaggaaat gtcagtgaag gcatgaaagg catcgttctt tttgtctcaa aagtacttga   1080

ggagcccaag gacttttctt gtgaaaccga ggacttcaag actttgcact gtacttggga   1140

tcctgggacg gacactgcct tggggtggtc taaacaacct tcccaaagct acactttatt   1200

tgaatcattt tctggggaaa agaaactttg tacacacaaa aactggtgta attggcaaat   1260

aactcaagac tcacaagaaa cctataactt cacactcata gctgaaaatt acttaaggaa   1320

gagaagtgtc aatatccttt ttaacctgac tcatcgagtt tatttaatga atccttttag   1380

tgtcaacttt gaaaatgtaa atgccacaaa tgccatcatg acctggaagg tgcactccat   1440

aaggaataat ttcacatatt tgtgtcagat tgaactccat ggtgaaggaa aaatgatgca   1500

atacaatgtt tccatcaagg tgaacggtga gtacttctta agtgaactgg aacctgccac   1560

agagtacatg gcgcgagtac ggtgtgctga tgccagccac ttctggaaat ggagtgaatg   1620

gagtggtcag aacttcacca cacttgaagc tgctccctca gaggcccctg atgtctggag   1680

aattgtgagc ttggagccag gaaatcatac tgtgacctta ttctggaagc cattatcaaa   1740

actgcatgcc aatggaaaga tcctgttcta taatgtagtt gtagaaaacc tagacaaacc   1800

atccagttca gagctccatt ccattccagc accagccaac agcacaaaac taatccttga   1860

caggtgttcc taccaaatct gcgtcatagc caacaacagt gtgggtgctt ctcctgcttc   1920

tgtaatagtc atctctgcag accccgaaaa caaagaggtt gaggaagaaa gaattgcagg   1980

cacagagggt ggattctctc tgtcttggaa accccaacct ggagatgtta taggctatgt   2040

tgtggactgg tgtgaccata cccaggatgt gctcggtgat ttccagtgga agaatgtagg   2100

tcccaatacc acaagcacag tcattagcac agatgctttt aggccaggag ttcgatatga   2160

cttcagaatt tatgggttat ctacaaaaag gattgcttgt ttattagaga aaaaaacagg   2220

atactctcag gaacttgctc cttcagacaa ccctcacgtg ctggtggata cattgacatc   2280

ccactccttc actctgagtt ggaaagatta ctctactgaa tctcaacctg gttttataca   2340

agggtaccat gtctatctga aatccaaggc gaggcagtgc cacccacgat ttgaaaaggc   2400

agttctttca gatggttcag aatgttgcaa atacaaaatt gacaacccgg aagaaaaggc   2460

attgattgtg gacaacctaa agccagaatc cttctatgag tttttcatca ctccattcac   2520

tagtgctggt gaaggcccca gtgctacgtt cacgaaggtc acgactccgg atgaacactc   2580

ctcgatgctg attcatatcc tactgcccat ggttttctgc gtcttgctca tcatggtcat   2640

gtgctacttg aaaagtcagt ggatcaagga gacctgttat cctgacatcc ctgaccctta   2700

caagagcagc atcctgtcat taataaaatt caaggagaac cctcacctaa taataatgaa   2760

tgtcagtgac tgtatcccag atgctattga agttgtaagc aagccagaag ggacaaagat   2820

acagttccta ggcactagga agtcactcac agaaaccgag ttgactaagc ctaactacct   2880

ttatctcctt ccaacagaaa agaatcactc tggccctggc ccctgcatct gttttgagaa   2940

cttgacctat aaccaggcag cttctgactc tggctcttgt ggccatgttc cagtatcccc   3000

aaaagcccca agtatgctgg gactaatgac ctcacctgaa aatgtactaa aggcactaga   3060

aaaaaactac atgaactccc tgggagaaat cccagctgga gaaacaagtt tgaattatgt   3120

gtcccagttg gcttcaccca tgtttggaga caaggacagt ctcccaacaa acccagtaga   3180

ggcaccacac tgttcagagt ataaaatgca aatggcagtc tccctgcgtc ttgccttgcc   3240

tcccccgacc gagaatagca gcctctcctc aattaccctt ttagatccag gtgaacacta   3300

ctgctaacca gcatgccgat ttcatacctt atgctacaca gacattaaga agagcagagc   3360

tggcaccctg tcatcaccag tggccttggt ccttaatccc agtacaattt gcaggtctgg   3420

tttatataag accactacag tctggctagg ttaaaggcca gaggctatgg aacttaacac   3480

tccccattgg agcaagcttg ccctagagac ggcaggatca tgggagcatg cttaccttct   3540

gctgtttgtt ccaggctcac ctttagaaca ggagacttga gcttgaccta aggatatgca   3600

ttaaccactc tacagactcc cactcagtac tgtacagggt ggctgtggtc ctagaagttc   3660

agtttttact gaggaaatat ttccattaac agcaattatt atattgaagg ctttaataaa   3720

ggccacagga gacattacta tagcatagat tgtcaaatgt aaatttactg agcgtgtttt   3780

ataaaaaact cacaggtgtt tgaggccaaa acagatttta gacttacctt gaacggataa   3840

gaatctatag ttcactgaca cagtaaaatt aactctgtgg gtgggggcgg ggggcatagc   3900

tctaatctaa tatataaaat gtgtgatgaa tcaacaagat ttccacaatt cttctgtcaa   3960

gcttactaca gtgaaagaat gggattggca agtaacttct gacttactgt cagttgtact   4020

tctgctccat agacatcagt attctgccat catttttgat gactacctca gaacataaaa   4080

aggaacgtat atcacataat tccagtcaca gtttttggtt cctcttttct ttcaagaact   4140

atatataaat gacctgtttt cacgcggccg c                                  4171


<210>  3
<211>  252
<212>  PRT
<213>  homo sapiens

<400>  3

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  4
<211>  1880
<212>  DNA
<213>  homo sapiens

<400>  4
agccgagagg tgtcaccccc agcgggcgcg ggccggagca cgggcaccca gcatgggggt     60

actgctcaca cagaggacgc tgctcagtct ggtccttgca ctcctgtttc caagcatggc    120

gagcatggcg gctataggca gctgctcgaa agagtaccgc gtgctccttg gccagctcca    180

gaagcagaca gatctcatgc aggacaccag cagactcctg gacccctata tacgtatcca    240

aggcctggat gttcctaaac tgagagagca ctgcagggag cgccccgggg ccttccccag    300

tgaggagacc ctgagggggc tgggcaggcg gggcttcctg cagaccctca atgccacact    360

gggctgcgtc ctgcacagac tggccgactt agagcagcgc ctccccaagg cccaggattt    420

ggagaggtct gggctgaaca tcgaggactt ggagaagctg cagatggcga ggccgaacat    480

cctcgggctc aggaacaaca tctactgcat ggcccagctg ctggacaact cagacacggc    540

tgagcccacg aaggctggcc ggggggcctc tcagccgccc acccccaccc ctgcctcgga    600

tgcttttcag cgcaagctgg agggctgcag gttcctgcat ggctaccatc gcttcatgca    660

ctcagtgggg cgggtcttca gcaagtgggg ggagagcccg aaccggagcc ggagacacag    720

cccccaccag gccctgagga agggggtgcg caggaccaga ccctccagga aaggcaagag    780

actcatgacc aggggacagc tgccccggta gcctcgagag caccccttgc cggtgaagga    840

tgcggcaggt gctctgtgga tgagaggaac catcgcagga tgacagctcc cgggtcccca    900

aacctgttcc cctctgctac tagccactga gaagtgcact ttaagaggtg ggagctgggc    960

agacccctct acctcctcca ggctgggaga cagagtcagg ctgttgcgct cccacctcag   1020

ccccaagttc cccaggccca gtggggtggc cgggcgggcc acgcgggacc gactttccat   1080

tgattcaggg gtctgatgac acaggctgac tcatggccgg gctgactgcc cccctgcctt   1140

gctccccgag gcctgccggt ccttccctct catgacttgc agggccgttg cccccagact   1200

tcctcctttc cgtgtttctg aaggggaggt cacagcctga gctggcctcc tatgcctcat   1260

catgtcccaa accagacacc tggatgtctg ggtgacctca ctttaggcag ctgtaacagc   1320

ggcagggtgt cccaggagcc ctgatccggg ggtccaggga atggagctca ggtcccaggc   1380

cagccccgaa gtcgccacgt ggcctggggc aggtcacttt acctctgtgg acctgttttc   1440

tctttgtgaa gctagggagt tagaggctgt acaaggcccc cactgcctgt cggttgcttg   1500

gattccctga cgtaaggtgg atattaaaaa tctgtaaatc aggacaggtg gtgcaaatgg   1560

cgctgggagg tgtacacgga ggtctctgta aaagcagacc cacctcccag cgccgggaag   1620

cccgtcttgg gtcctcgctg ctggctgctc cccctggtgg tggatcctgg aattttctca   1680

cgcaggagcc attgctctcc tagagggggt ctcagaaact gcgaggccag ttccttggag   1740

ggacatgact aatttatcga tttttatcaa tttttatcag ttttatattt ataagcctta   1800

tttatgatgt atatttaatg ttaatattgt gcaaacttat atttaaaact tgcctggttt   1860

ctaaaaaaaa aaaaaaaaaa                                               1880


