                         SEQUENCE LISTING

<110>  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
       JOHANNING, FENG-WANG
 
<120>  HERV-K ANTIGENS, ANTIBODIES, AND METHODS

<130>  019856.0300

<150>  US 12/475,009
<151>  2009-05-29

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  1
atcccgagta catctacagt cagccttac                                         29


<210>  2
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  2
gacatttgaa gttctacaat gaacccatc                                         29


<210>  3
<211>  7
<212>  DNA
<213>  Homo sapiens

<400>  3
tctctat                                                                  7


<210>  4
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  4
tcaaaactga caatg                                                        15


<210>  5
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  5
cttttccaaa tctctcatcc caccttacga gaaa                                   34


<210>  6
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  6
atcagcttcc tgtttggata cccactag                                          28


<210>  7
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  7
atttctataa atgtttaaaa aatttaaagt atagag                                 36


<210>  8
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  8
aaagaaataa ggggacccgg ggaaccagc                                         29


<210>  9
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  9
ttgacgagag atcccgagta catctacagt cagccttgcg ggaga                       45


<210>  10
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  10
gcaccaggat gtttaatgcc taagc                                             25


<210>  11
<211>  763
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic anti HERV-K scFV 
       4d1 polynucleotide

<400>  11
ggcccagccg gccatggccc aggtccagct gcaggagtca ggaggtggcc tggtgcagcc       60

tggaggatcc ctgaaactct cctgtgcagc ctcaggattc gattttagta gatactggat      120

gagttgggtc cggcaggctc cagggaaagg gctagaatgg attggagaaa ttaatccaga      180

tagcagtacg ataaactata cgccatctct aaaggataaa ttcatcatct ccagagacaa      240

cgccaaaaat acgctgtacc tgcaaatgag caaagtgaga tctgaggaca cagcccttta      300

ttactgtgca agacgagggt actacggtag tagctactgg tttgcttact ggggccaagg      360

caccacggtc accgtctcct caggtggagg cggttcaggc ggaggtggcg ctggcggtgg      420

cggatcggac atcgagctca ctcagtctcc agcaatcatg tctgcatctc taggagaacg      480

ggtcaccatg acctgcactg ccagctcaag tgtaagttcc agttacttgc actggtacca      540

gcagaagcca ggatcctccc ccaaactctg gatttatagc acatccaacc tggcttctgg      600

agtcccagct cgcttcagtg gcagtgggtc tgggacctct tactctctca caatcagcag      660

catggaggct gaagatgctg ccacttatta ctgccaccag tatcatcgtt ccccacccac      720

gttcggctcg ggcaccaagc tggaaatcaa acgggcggcc gca                        763


<210>  12
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic anti HERV-K scFV 
       polypeptide

<400>  12

Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30          


Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
    50                  55                  60                  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Pro Thr Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Glu 
                245                 250     


<210>  13
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv 
       polynucleotide

<400>  13
atggcccagg tccagctgca ggagtcagga ggtggcctgg tgcagcctgg aggatccctg       60

aaactctcct gtgcagcctc aggattcgat tttagtagat actggatgag ttgggtccgg      120

caggctccag ggaaagggct agaatggatt ggagaaatta atccagatag cagtacgata      180

aactatacgc catctctaaa ggataaattc atcatctcca gagacaacgc caaaaatacg      240

ctgtacctgc aaatgagcaa agtgagatct gaggacacag ccctttatta ctgtgcaaga      300

cgagggtact acggtagtag ctactggttt gcttactggg gccaaggcac cacggtcacc      360

gtctcctcag gtggaggcgg ttcaggcgga ggtggcgctg gcggtggcgg atcggacatc      420

gagctcactc agtctccagc aatcatgtct gcatctctag gagaacgggt caccatgacc      480

tgcactgcca gctcaagtgt aagttccagt tacttgcact ggtaccagca gaagccagga      540

tcctccccca aactctggat ttatagcaca tccaacctgg cttctggagt cccagctcgc      600

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      660

gatgctgcca cttattactg ccaccagtat catcgttccc cacccacgtt cggctcgggc      720

accaagctgg aaatcaaacg ggcggccgca                                       750


<210>  14
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv 
       polypeptide

<400>  14

Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30          


Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
    50                  55                  60                  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Pro Thr Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg 
                245         


<210>  15
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable region of 4D1 scFv polynucleotide

<400>  15
atggcccagg tccagctgca ggagtcagga ggtggcctgg tgcagcctgg aggatccctg       60

aaactctcct gtgcagcctc aggattcgat tttagtagat actggatgag ttgggtccgg      120

caggctccag ggaaagggct agaatggatt ggagaaatta atccagatag cagtacgata      180

aactatacgc catctctaaa ggataaattc atcatctcca gagacaacgc caaaaatacg      240

ctgtacctgc aaatgagcaa agtgagatct gaggacacag ccctttatta ctgtgcaaga      300

cgagggtact acggtagtag ctactggttt gcttact                               337


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable region of 4D1 scFv polypeptide

<400>  16

Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30          


Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
    50                  55                  60                  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
            100                 105                 110         


<210>  17
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable region of 4D1 scFv polynucleotide

<400>  17
gcaatcatgt ctgcatctct aggagaacgg gtcaccatga cctgcactgc cagctcaagt       60

gtaagttcca gttacttgca ctggtaccag cagaagccag gatcctcccc caaactctgg      120

atttatagca catccaacct ggcttctgga gtcccagctc gcttcagtgg cagtgggtct      180

gggacctctt actctctcac aatcagcagc atggaggctg aagatgctgc cacttattac      240

tgccaccagt atcatcgttc cccacccacg ttcggctcgg gcaccaagct ggaaatcaaa      300

cgg                                                                    303


<210>  18
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable region of 4D1 scFv polypeptide

<400>  18

Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr 
1               5                   10                  15      


Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala 
        35                  40                  45              


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    50                  55                  60                  


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys His Gln Tyr His Arg Ser Pro Pro Thr Phe Gly Ser Gly Thr Lys 
                85                  90                  95      


Leu Glu Ile Lys Arg 
            100     


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR H1 
       oligonucleotide

<400>  19
ggattcgatt ttagtagata ctggatgagt                                        30


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR H1 
       peptide

<400>  20

Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser 
1               5                   10  


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR H2 
       oligonucleotide

<400>  21
gaaattaatc cagatagcag tacgataaac tatacgccat ctctaaagga t                51


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR H2 
       peptide

<400>  22

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR H3 
       oligonucleotide

<400>  23
cgagggtact acggtagtag ctactggttt gcttac                                 36


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Arg Gly Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10          


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR L1 
       oligonucleotide

<400>  25
actgccagct caagtgtaag ttccagttac ttgcac                                 36


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR L2 
       oligonucleotide

<400>  27
agcacatcca acctggcttc t                                                 21


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  28

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 4D1 scFv CDR L3 
       oligonucleotide

<400>  29
caccagtatc atcgttcccc acccacg                                           27


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  30

His Gln Tyr His Arg Ser Pro Pro Thr 
1               5                   


<210>  31
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 4D1 scFv 
       polynucleotide

<400>  31
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgattttagt agatactgga tgagctgggt ccgccaggct      120

ccagggaaag ggctggagtg ggtggccaac attaatccag atagcagtac gatatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc aagacgaggg      300

tactacggta gtagctactg gtttgcttac tggggccaag gcaccacggt caccgtctcc      360

tcaggtggag gcggttcagg cggaggtggc gctggcggtg gcggatcgga catcgagctc      420

actcagtctc cagaaatagt gatgacgcag tctccagcca ccctgtctgt gtctccaggg      480

gaaagagcca ccctctcctg cagggccagt tcaagtgtaa gttccagtta cttagcctgg      540

taccagcaga aacctggcca ggctcccagg ctcctcatct atagcacatc caccagggcc      600

actggtatcc cagccaggtt cagtggcagt gggtctggga cagagttcac tctcaccatc      660

agcagcctgc agtctgaaga ttttgcagtt tattactgtc accagtatca tcgttcccca      720

cccacgttcg gctcgggcac caagctggaa atcaaacgg                             759


<210>  32
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 4D1 scFv 
       polypeptide

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser His Gly 
                165                 170                 175     


Thr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Arg Ala Ser Asn Lys Asp Thr Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro 
    210                 215                 220                 


Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn Glu 
225                 230                 235                 240 


Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 


<210>  33
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable region of humanized Ab 4D1 scFv polynucleotide

<400>  33
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgattttagt agatactgga tgagctgggt ccgccaggct      120

ccagggaaag ggctggagtg ggtggccaac attaatccag atagcagtac gatatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc aagacgaggg      300

tactacggta gtagctactg gtttgcttac t                                     331


<210>  34
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable region of humanized Ab 4D1 scFv polypeptide

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser His Gly 
                165                 170                 175     


Thr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Arg Ala Ser Asn Lys Asp Thr Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro 
    210                 215                 220                 


Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn Glu 
225                 230                 235                 240 


Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 


<210>  35
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable region for humanized 4D1 scFv polynucleotide

<400>  35
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagttc aagtgtaagt tccagttact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat agcacatcca ccagggccac tggtatccca      180

gccaggttca gtggcagtgg gtctgggaca gagttcactc tcaccatcag cagcctgcag      240

tctgaagatt ttgcagttta ttactgtcac cagtatcatc gttccccacc cacgttcggc      300

tcgggcacca agctggaaat caaacgg                                          327


<210>  36
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable region for humanized 4D1 scFv polypeptide

<400>  36

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-H1 of heavy 
       chain variable region of humanized 4D1 Ab oligonucleotide

<400>  37
ggattcgatt ttagtagata ctgg                                              24


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-H1 of heavy 
       chain humanized 4D1 scFv peptide

<400>  38

Gly Phe Asp Phe Ser Arg Tyr Trp 
1               5               


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-H2 of heavy 
       chain variable region of humanized 4D1 Ab oligonucleotide

<400>  39
attaatccag atagcagtac gata                                              24


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-H2 humanized
       Ab peptide

<400>  40

Ile Asn Pro Asp Ser Ser Thr Ile 
1               5               


<210>  41
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-H3 of heavy 
       chain variable region of humanized 4D1 Ab oligonucleotide

<400>  41
gcaagacgag ggtactacgg tagtagctac tggtttgctt ac                          42


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR3 of heavy 
       chain variable region of humanized 4D1 Ab peptide

<400>  42

Ala Arg Arg Gly Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10                  


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L1 of the 
       light chain variable region for humanized 4D1 scFv 
       oligonucleotide

<400>  43
tcaagtgtaa gttccagtta c                                                 21


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L1 of the 
       light chain variable region for humanized 4D1 scFv peptide

<400>  44

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  45
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L2 of the 
       light chain variable region for humanized 4D1 scFv 
       oligonucleotide

<400>  45
agcacatcc                                                                9


<210>  46
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L2 of the 
       light chain variable region for humanized 4D1 scFv peptide

<400>  46

Ser Thr Ser 
1           


<210>  47
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L3 of the 
       light chain variable region for humanized 4D1 scFv 
       oligonucleotide

<400>  47
caccagtatc atcgttcccc acccacg                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic muCDR-L3 of the 
       light chain variable region for humanized 4D1 scFv peptide

<400>  48

His Gln Tyr His Arg Ser Pro Pro Thr 
1               5                   


<210>  49
<211>  745
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv 
       polynucleotide

<400>  49
atggcccagg tgaagctgca gcagtcagga cctgacctgg tgaagcctgg ggcttcagtg       60

aagatatcct gcaaggcgtc tggttactca ttcactggct actacatgca ctgggtgaag      120

cagagccatg gaaagagcct tgagtggatt ggacgtgtta atcctaacag tggtggtaca      180

agctacaacc agaagttcaa ggacaaggcc atattaactg tagacaagtc atccagcaca      240

gcctacatgg agctccgcag cctgacatct gaggactctg cggtctatta ctgtgcaaga      300

tcgaaaggta actacttcta tgctatggac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaagtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc ggacatcgag      420

ctcactcagt ctccagcttc tttggctgtg tctctagggc agagggccac catatcctgc      480

agagccagtg aaagtgttga tagtcatggc actagtttta tgcactggta ccagcagaaa      540

ccaggacagc cacccaaatt cctcatctat cgtgcatcca acctagaatc tgggatccct      600

gccaggttca gtggcagtgg gtctaggaca gacttcaccc tcaccattaa tcctgtggag      660

acagatgatg ttgcaatcta ttactgtcag caaagtaatg aggatcctcc gacgttcggt      720

ggaggcacca agctggaaat caaac                                            745


<210>  50
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv 
       polypeptide

<400>  50

Met Ala Gln Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Val Asn Pro Asn Ser Gly Gly Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Ser Val Asp Ser His Gly Thr Ser Phe Met His Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr Arg Ala 
            180                 185                 190         


Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val 
    210                 215                 220                 


Ala Ile Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Lys 
                245             


<210>  51
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv heavy 
       chain variable region polynucleotide

<400>  51
atggcccagg tgaagctgca gcagtcagga cctgacctgg tgaagcctgg ggcttcagtg       60

aagatatcct gcaaggcgtc tggttactca ttcactggct actacatgca ctgggtgaag      120

cagagccatg gaaagagcct tgagtggatt ggacgtgtta atcctaacag tggtggtaca      180

agctacaacc agaagttcaa ggacaaggcc atattaactg tagacaagtc atccagcaca      240

gcctacatgg agctccgcag cctgacatct gaggactctg cggtctatta ctgtgcaaga      300

tcgaaaggta actacttcta tgctatggac tact                                  334


<210>  52
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv heavy 
       chain variable region polypeptide

<400>  52

Met Ala Gln Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Val Asn Pro Asn Ser Gly Gly Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr 
            100                 105                 110     


<210>  53
<211>  310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv light 
       chain variable region polynucleotide

<400>  53
gcttctttgg ctgtgtctct agggcagagg gccaccatat cctgcagagc cagtgaaagt       60

gttgatagtc atggcactag ttttatgcac tggtaccagc agaaaccagg acagccaccc      120

aaattcctca tctatcgtgc atccaaccta gaatctggga tccctgccag gttcagtggc      180

agtgggtcta ggacagactt caccctcacc attaatcctg tggagacaga tgatgttgca      240

atctattact gtcagcaaag taatgaggat cctccgacgt tcggtggagg caccaagctg      300

gaaatcaaac                                                             310


<210>  54
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6H5 scFv light 
       chain variable region polypeptide

<400>  54

Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
1               5                   10                  15      


Ala Ser Glu Ser Val Asp Ser His Gly Thr Ser Phe Met His Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr Arg Ala Ser 
        35                  40                  45              


Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg 
    50                  55                  60                  


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala 
65                  70                  75                  80  


Ile Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile Lys 
            100             


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H1 of 6H5 scFv 
       heavy chain variable region oligonucleotide

<400>  55
ggttactcat tcactggcta ctacatgcac                                        30


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H1 of 6H5 scFv 
       heavy chain variable region peptide

<400>  56

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  57
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H2 of 6H5 scFv 
       heavy chain variable region oligonucleotide

<400>  57
cgtgttaatc ctaacagtgg tggtacaagc tacaaccaga agttcaag                    48


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H2 H chain 
       peptide

<400>  58

Arg Val Asn Pro Asn Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  59
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H3 of 6H5 
       oligonucleotide

<400>  59
tcgaaaggta actacttcta tgctatggac tac                                    33


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR-H3 of 6H5 
       peptide

<400>  60

Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  61
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L1 of 6H5 scFv 
       light chain variable region oligonucleotide

<400>  61
agagccagtg aaagtgttga tagtcatggc actagtttta tgcac                       45


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L1 of 6H5 scFv 
       light chain variable region peptide

<400>  62

Arg Ala Ser Glu Ser Val Asp Ser His Gly Thr Ser Phe Met His 
1               5                   10                  15  


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L2 of 6H5 scFv 
       light chain variable region oligonucleotide

<400>  63
cgtgcatcca acctagaatc t                                                 21


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L2 of 6H5 scFv 
       light chain variable region peptide

<400>  64

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L3 of 6H5 scFv 
       light chain variable region oligonucleotide

<400>  65
cagcaaagta atgaggatcc tccgacg                                           27


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CDR L3 of 6H5 scFv 
       light chain variable region peptide

<400>  66

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  67
<211>  763
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       polynucleotide

<400>  67
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg gttaatccta acagtggtgg tacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc aagatcgaaa      300

ggtaactact tctatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      360

agtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcggacat cgagctcact      420

cagtctccag acattgtgct gacccagtct ccagcctcct tggccgtgtc tccaggacag      480

agggccacca tcacctgcag agccagtgaa agtgttgata gtcatggcac tagttttatt      540

cactggtatc agcagaaacc aggacaacct cctaaactcc tgatttaccg tgcatccaat      600

aaagacactg gggtcccagc caggttcagc ggcagtgggt ctgggaccga tttcaccctc      660

acaattaatc ctgtggaagc taatgatact gcaaattatt actgtcagca aagtaatgag      720

gatcctccga cgttcggtgg aggcaccaag ctggaaatca aac                        763


<210>  68
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       polypeptide

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser His Gly 
                165                 170                 175     


Thr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Arg Ala Ser Asn Lys Asp Thr Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro 
    210                 215                 220                 


Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn Glu 
225                 230                 235                 240 


Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 


<210>  69
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       heavy chain variable polynucleotide

<400>  69
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg gttaatccta acagtggtgg tacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc aagatcgaaa      300

ggtaactact tctatgctat ggactact                                         328


<210>  70
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       heavy chain variable region polypeptide

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr 
            100                 105                 


<210>  71
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       light chain variable polynucleotide

<400>  71
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtga aagtgttgat agtcatggca ctagttttat tcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc gtgcatccaa taaagacact      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtcagc aaagtaatga ggatcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaac                                  334


<210>  72
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic humanized 6H5 scFv 
       Light chain variable region polypeptide

<400>  72

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser His 
            20                  25                  30          


Gly Thr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Lys Asp Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  73
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H1 from 
       humanized 6H5 scFv heavy chain oligonucleotide

<400>  73
ggttactcat tcactggcta ctac                                              24


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H1 from 
       Humanized 6H5 scFv heavy chain peptide

<400>  74

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H2 from 
       humanized 6H5 scFv heavy chain oligonucleotide

<400>  75
gttaatccta acagtggtgg taca                                              24


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H2 from 
       humanized 6H5 scFv heavy chain peptide

<400>  76

Val Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  77
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H3 from 
       humanized 6H5 scFv heavy chain oligonucleotide

<400>  77
gcaagatcga aaggtaacta cttctatgct atggactac                              39


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR H3 from 
       humanized 6H5 scFv heavy chain peptide

<400>  78

Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L1 from 
       humanized 6H5 scFv light chain oligonucleotide

<400>  79
gaaagtgttg atagtcatgg cactagtttt                                        30


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L1 from 
       humanized 6H5 scFv light chain peptide

<400>  80

Glu Ser Val Asp Ser His Gly Thr Ser Phe 
1               5                   10  


<210>  81
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L2 from 
       humanized 6H5 scFv light chain oligonucleotide

<400>  81
cgtgcatcc                                                                9


<210>  82
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L2 from 
       humanized 6H5 scFv light chain peptide

<400>  82

Arg Ala Ser 
1           


<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L3 from 
       humanized 6H5 scFv light chain oligonucleotide

<400>  83
cagcaaagta atgaggatcc tccgacg                                           27


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic mu-CDR-L3 from 
       humanized 6H5 scFv light chain peptide

<400>  84

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  85
<211>  368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv heavy
       chain variable region polynucleotide

<400>  85
gcttaggtga agctgcagga gtcaggtgga gggttggtgc agcctaaagg gtcattgaaa       60

ctctcatgtg cagcctctgg attcaccttc aatacctacg ccatgaactg ggtccgccag      120

gctccaggaa agggtttgga gtgggttgct cgcataagaa ctaaaagtaa tggttatgca      180

acatcttatg ccgattcagt gagagacagg ttcaccatct ccagagatga ttcacaaagc      240

atgctctatc tgcaaatgaa caccttgaaa actgaggaca cagccatgta ttgctgtgtg      300

agagaggggg actgggcctg gtttgcttac tggggccaag ggaccacggt caccgtctcc      360

tcaaagcc                                                               368


<210>  86
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv heavy
       chain variable region polypeptide

<400>  86

Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly Ser 
1               5                   10                  15      


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Arg Ile Arg Thr Lys Ser Asn Gly Tyr Ala Thr Ser Tyr Ala Asp Ser 
    50                  55                  60                  


Val Arg Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Thr Leu Lys Thr Glu Asp Thr Ala Met Tyr Cys 
                85                  90                  95      


Cys Val Arg Glu Gly Asp Trp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Lys 
        115                 120 


<210>  87
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polynucleotide

<400>  87
cttccgtttc agctccagct tggtcccccc tccgaacgtg tacagattat aagattgctt       60

gcagtaataa actgccaggt cttcagcctg cacactgttg atggtgagag tgaaatctgt      120

cccagatcca ctgcctgtga agcgatcagg gaccccagat tccctagtgg atgcccagta      180

gatcagcagt ttaggagact gccctggttt ctgctggtac caagccaagt agttctttcg      240

ggttctactg ttgagcagac tctgactgga tttgcagctc atagtgacct tctctcctgc      300

tgacacagcc agggaggatg gagactgggt cagcacaatg tcaagcc                    347


<210>  88
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polypeptide


<400>  88

Leu Pro Phe Gln Leu Gln Leu Gly Pro Pro Ser Glu Arg Val Gln Ile 
1               5                   10                  15      


Ile Arg Leu Leu Ala Val Ile Asn Cys Gln Val Phe Ser Leu His Thr 
            20                  25                  30          


Val Asp Gly Glu Ser Glu Ile Cys Pro Arg Ser Thr Ala Cys Glu Ala 
        35                  40                  45              


Ile Arg Asp Pro Arg Phe Pro Ser Gly Cys Pro Val Asp Gln Gln Phe 
    50                  55                  60                  


Arg Arg Leu Pro Trp Phe Leu Leu Val Pro Ser Gln Val Val Leu Ser 
65                  70                  75                  80  


Gly Ser Thr Val Glu Gln Thr Leu Thr Gly Phe Ala Ala His Ser Asp 
                85                  90                  95      


Leu Leu Ser Cys 
            100 


<210>  89
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polynucleotide

<400>  89
cttgacatcc agatgactca gtctccatcc tccctggctg tgtcagcagg agagaaggtc       60

actatgagct gcaaatccag tcagagtctg ctcaacagta gaacccgaaa gaactacttg      120

gctgggtacc agcagaaacc agggcagtct cctaaactgc tgatctactg ggcatccact      180

agggaatctg gggtccctga tcgcttcaca ggcagtggat ctgggacaga tttcactctc      240

accatcaaca gtgtgcaggc tgaagacctg gcagtttatt actgcaagca atcttataat      300

ctgtacacgt tcggaggggg caccaagctg gaaatcaaac ggaagcc                    347


<210>  90
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polypeptide

<400>  90

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala 
1               5                   10                  15      


Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn 
            20                  25                  30          


Ser Arg Thr Arg Lys Asn Tyr Leu Ala Gly Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Gln Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Lys 
        115 


<210>  91
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polynucleotide

<400>  91
cggcttgaaa atgtgctcac ccagtctcca gcttctttgg ctgtgtctct agggcagagg       60

gccaccatat cctgcagagc cagtgaaagt gttgatagtc atggcactag ttttatgcac      120

tggtaccagc agaaaccagg acagccaccc aaattcctca tctatcgtgc atccaaccta      180

gaatctggga tccctgccag gttcagtggc agtgggtcta ggacagactt caccctcacc      240

attaatcctg tggagacaga tgatgttgca atctattact gtcagcaaag taatgaggat      300

cctccgacgt tcggtggagg caccaagctg gaaatcaaac ggaagccg                   348


<210>  92
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv light
       chain variable region polypeptide

<400>  92

Arg Leu Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            20                  25                  30          


Ser His Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Phe Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Pro Val Glu Thr Asp Asp Val Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Asn Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Lys Pro 
        115     


<210>  93
<211>  640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv 
       polynucleotide

<400>  93
atggcccagg tgaagctgca gcagtcagga cctgacctgg tgaagcctgg ggcttcagtg       60

aagatatcct gcaaggcgtc tggttactca ttcactggct actacatgca ctgggtgaag      120

cagagccatg gaaagagcct tgagtggatt ggacgtgtta atcctaacag tggtggtaca      180

agctacaacc agaagttcaa ggacaaggcc atattaactg tagacaagcc atccagcaca      240

gcctacatgg agctccgcag cctgacatct gaggactctg cggtctatta ctgtgcaaga      300

tcgaaaggta actacttcta tgctatggac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaagtg gaggcggttc agtcggaggt ggctctggcg gtggcggatc ggacatcgag      420

ctcactcagt ctccagcttc tttggctgtg tctctagggc agagggccac catatcctgc      480

agagccagtg aaagtgttga tagtcatggc actagtttta tgcactggta ccagcagaaa      540

ccaggacagc cacccaaatt cctcatctat cgtgcatcca acctagaatc tgggatccct      600

gccaggttca gtggcagtgg gtctaggaca gacttcaccc                            640


<210>  94
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6E11 scFv polypeptide

<400>  94

Met Ala Gln Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Val Asn Pro Asn Ser Gly Gly Thr Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Pro Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Lys Gly Asn Tyr Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Val 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Ser Val Asp Ser His Gly Thr Ser Phe Met His Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr Arg Ala 
            180                 185                 190         


Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Arg Thr Asp Phe Thr 
    210             


